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Conserved domains on  [gi|1622945903|ref|XP_028705426|]
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calpastatin isoform X20 [Macaca mulatta]

Protein Classification

calpastatin family protein( domain architecture ID 10286369)

calpastatin family protein specifically inhibits calpain (calcium-dependent cysteine protease)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
368-496 4.92e-36

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 132.06  E-value: 4.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 368 LIDELSEDFDPSKYKEKPSKPTEKTEESKAAAPAPVAEavSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEAD 447
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAEKSSAPAASGEVV--SAASASSVKSAAPPPEKKRKKVPDDALDALSDSLGGREPD 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622945903 448 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
Cdd:pfam00748  79 PEEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
231-354 1.04e-28

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 111.26  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 231 AIDALSSDFTCGSPTAAGKKTEKEE--------STEVLKAQSAGTVRSAAPPQEKKRKvekdTMSDQALEALSASLGTRQ 302
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAekssapaaSGEVVSAASASSVKSAAPPPEKKRK----KVPDDALDALSDSLGGRE 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622945903 303 AEPELDLSSIKEVDEaKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP 354
Cdd:pfam00748  77 PDPEEPKPPVDKVKE-KAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
511-633 7.76e-24

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 97.39  E-value: 7.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 511 LLDALSEDFSGPQNASSL-----KFEDAKLAAAISEVVSQTPASTTHTGAPPRDTSQSDKDLDDALDKLSdSLGQRQPDP 585
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVkkpapKAEKSSAPAASGEVVSAASASSVKSAAPPPEKKRKKVPDDALDALSD-SLGGREPDP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622945903 586 DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVKP 633
Cdd:pfam00748  80 EEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib super family cl08287
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
87-220 7.22e-05

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


The actual alignment was detected with superfamily member pfam00748:

Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 43.08  E-value: 7.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  87 SAEQQPSEKSAEPKTKPQDTVSAGGESVAGVAATSGKPGDKQKEKKslapalpveskpdkpsGKSGMDAALDDLIDTLGG 166
Cdd:pfam00748  11 SSSAAPKVKKPAPKAEKSSAPAASGEVVSAASASSVKSAAPPPEKK----------------RKKVPDDALDALSDSLGG 74
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622945903 167 PEETEEENTTYtGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKTEGITGPPP 220
Cdd:pfam00748  75 REPDPEEPKPP-VDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
368-496 4.92e-36

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 132.06  E-value: 4.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 368 LIDELSEDFDPSKYKEKPSKPTEKTEESKAAAPAPVAEavSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEAD 447
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAEKSSAPAASGEVV--SAASASSVKSAAPPPEKKRKKVPDDALDALSDSLGGREPD 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622945903 448 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
Cdd:pfam00748  79 PEEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
231-354 1.04e-28

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 111.26  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 231 AIDALSSDFTCGSPTAAGKKTEKEE--------STEVLKAQSAGTVRSAAPPQEKKRKvekdTMSDQALEALSASLGTRQ 302
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAekssapaaSGEVVSAASASSVKSAAPPPEKKRK----KVPDDALDALSDSLGGRE 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622945903 303 AEPELDLSSIKEVDEaKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP 354
Cdd:pfam00748  77 PDPEEPKPPVDKVKE-KAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
511-633 7.76e-24

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 97.39  E-value: 7.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 511 LLDALSEDFSGPQNASSL-----KFEDAKLAAAISEVVSQTPASTTHTGAPPRDTSQSDKDLDDALDKLSdSLGQRQPDP 585
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVkkpapKAEKSSAPAASGEVVSAASASSVKSAAPPPEKKRKKVPDDALDALSD-SLGGREPDP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622945903 586 DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVKP 633
Cdd:pfam00748  80 EEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
87-220 7.22e-05

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 43.08  E-value: 7.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  87 SAEQQPSEKSAEPKTKPQDTVSAGGESVAGVAATSGKPGDKQKEKKslapalpveskpdkpsGKSGMDAALDDLIDTLGG 166
Cdd:pfam00748  11 SSSAAPKVKKPAPKAEKSSAPAASGEVVSAASASSVKSAAPPPEKK----------------RKKVPDDALDALSDSLGG 74
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622945903 167 PEETEEENTTYtGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKTEGITGPPP 220
Cdd:pfam00748  75 REPDPEEPKPP-VDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
PTZ00121 PTZ00121
MAEBL; Provisional
246-701 3.80e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  246 AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRkveKDTMSDQALEALSASLGTRQAEpeldlSSIKEVDEAKAKEEKL 325
Cdd:PTZ00121  1270 AAIKAEEARKADELKKAEEKKKADEAKKAEEKKK---ADEAKKKAEEAKKADEAKKKAE-----EAKKKADAAKKKAEEA 1341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  326 EKCGE--DDETIPSEYRLKPATDKDGKPLLPEPEEKPKARSESELIDELSEDFDPSKYKEKPSKPTE---KTEESKAAAP 400
Cdd:PTZ00121  1342 KKAAEaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADelkKAAAAKKKAD 1421
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  401 APVAEAVSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
Cdd:PTZ00121  1422 EAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  481 YRLEEVKDKDGKPLLPKESK---EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTHTGAPP 557
Cdd:PTZ00121  1502 AKKAAEAKKKADEAKKAEEAkkaDEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR 1581
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  558 RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDkvkEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVK----- 632
Cdd:PTZ00121  1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE---AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeee 1658
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622945903  633 PPTKKSEESKKSADDQDPIDALSGDLDSCPSTTETSQNTAKDKRKKTASSSKAPKNGGKAKDSAKTTEE 701
Cdd:PTZ00121  1659 NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
368-496 4.92e-36

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 132.06  E-value: 4.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 368 LIDELSEDFDPSKYKEKPSKPTEKTEESKAAAPAPVAEavSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEAD 447
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAEKSSAPAASGEVV--SAASASSVKSAAPPPEKKRKKVPDDALDALSDSLGGREPD 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622945903 448 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 496
Cdd:pfam00748  79 PEEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
231-354 1.04e-28

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 111.26  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 231 AIDALSSDFTCGSPTAAGKKTEKEE--------STEVLKAQSAGTVRSAAPPQEKKRKvekdTMSDQALEALSASLGTRQ 302
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVKKPAPKAekssapaaSGEVVSAASASSVKSAAPPPEKKRK----KVPDDALDALSDSLGGRE 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622945903 303 AEPELDLSSIKEVDEaKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP 354
Cdd:pfam00748  77 PDPEEPKPPVDKVKE-KAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
511-633 7.76e-24

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 97.39  E-value: 7.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903 511 LLDALSEDFSGPQNASSL-----KFEDAKLAAAISEVVSQTPASTTHTGAPPRDTSQSDKDLDDALDKLSdSLGQRQPDP 585
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKVkkpapKAEKSSAPAASGEVVSAASASSVKSAAPPPEKKRKKVPDDALDALSD-SLGGREPDP 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622945903 586 DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVKP 633
Cdd:pfam00748  80 EEPKPPVDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
87-220 7.22e-05

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 425849 [Multi-domain]  Cd Length: 127  Bit Score: 43.08  E-value: 7.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  87 SAEQQPSEKSAEPKTKPQDTVSAGGESVAGVAATSGKPGDKQKEKKslapalpveskpdkpsGKSGMDAALDDLIDTLGG 166
Cdd:pfam00748  11 SSSAAPKVKKPAPKAEKSSAPAASGEVVSAASASSVKSAAPPPEKK----------------RKKVPDDALDALSDSLGG 74
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622945903 167 PEETEEENTTYtGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKTEGITGPPP 220
Cdd:pfam00748  75 REPDPEEPKPP-VDKVKEKAKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 127
PTZ00121 PTZ00121
MAEBL; Provisional
246-701 3.80e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  246 AAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRkveKDTMSDQALEALSASLGTRQAEpeldlSSIKEVDEAKAKEEKL 325
Cdd:PTZ00121  1270 AAIKAEEARKADELKKAEEKKKADEAKKAEEKKK---ADEAKKKAEEAKKADEAKKKAE-----EAKKKADAAKKKAEEA 1341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  326 EKCGE--DDETIPSEYRLKPATDKDGKPLLPEPEEKPKARSESELIDELSEDFDPSKYKEKPSKPTE---KTEESKAAAP 400
Cdd:PTZ00121  1342 KKAAEaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADelkKAAAAKKKAD 1421
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  401 APVAEAVSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480
Cdd:PTZ00121  1422 EAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  481 YRLEEVKDKDGKPLLPKESK---EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTHTGAPP 557
Cdd:PTZ00121  1502 AKKAAEAKKKADEAKKAEEAkkaDEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALR 1581
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622945903  558 RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDkvkEKAKAEHRDKLGERDDTIPPEYRHLLDDKGQDKPVK----- 632
Cdd:PTZ00121  1582 KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE---AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeee 1658
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622945903  633 PPTKKSEESKKSADDQDPIDALSGDLDSCPSTTETSQNTAKDKRKKTASSSKAPKNGGKAKDSAKTTEE 701
Cdd:PTZ00121  1659 NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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