NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370486239|ref|XP_024309666|]
View 

PACRG-like protein isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ParcG super family cl20396
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
64-147 4.30e-21

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


The actual alignment was detected with superfamily member pfam10274:

Pssm-ID: 431190  Cd Length: 183  Bit Score: 83.88  E-value: 4.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486239  64 PKTINPV-----HSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLTSLS----KR---------LMDKKFKEPITSA 122
Cdd:pfam10274  79 PQLILPLkaalnTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPVLNlfknKRvnlgdridyRKRKNIGDLIQET 158
                          90       100
                  ....*....|....*....|....*
gi 1370486239 123 LQKLEQHGGSGSLSIIKSKIPTYCS 147
Cdd:pfam10274 159 LELLERNGGPDALINIKYMIPTYES 183
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
64-147 4.30e-21

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 83.88  E-value: 4.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486239  64 PKTINPV-----HSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLTSLS----KR---------LMDKKFKEPITSA 122
Cdd:pfam10274  79 PQLILPLkaalnTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPVLNlfknKRvnlgdridyRKRKNIGDLIQET 158
                          90       100
                  ....*....|....*....|....*
gi 1370486239 123 LQKLEQHGGSGSLSIIKSKIPTYCS 147
Cdd:pfam10274 159 LELLERNGGPDALINIKYMIPTYES 183
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
64-147 4.30e-21

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 83.88  E-value: 4.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370486239  64 PKTINPV-----HSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLTSLS----KR---------LMDKKFKEPITSA 122
Cdd:pfam10274  79 PQLILPLkaalnTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPVLNlfknKRvnlgdridyRKRKNIGDLIQET 158
                          90       100
                  ....*....|....*....|....*
gi 1370486239 123 LQKLEQHGGSGSLSIIKSKIPTYCS 147
Cdd:pfam10274 159 LELLERNGGPDALINIKYMIPTYES 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH