NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1370470618|ref|XP_024306459|]
View 

glial fibrillary acidic protein isoform X2 [Homo sapiens]

Protein Classification

intermediate filament family protein( domain architecture ID 12057329)

intermediate filament family protein similar to desmin, a muscle-specific type III intermediate filament essential for proper muscular structure and function

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
68-444 3.46e-124

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 365.40  E-value: 3.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  68 SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK---EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 145 AQDLATVRQKLQDETNLRLEAENNLAAYRQvrevegrgrggrkglmathpntapklsppeqcaaphcprrrgkarlrnge 224
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRK-------------------------------------------------- 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 225 kepgapvalysspllplqEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVA-KPDLTAAL 303
Cdd:pfam00038 111 ------------------DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSAL 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 304 KEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEE 383
Cdd:pfam00038 173 AEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEE 252

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370470618 384 RHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 444
Cdd:pfam00038 253 RYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 3-66 3.58e-07

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


:

Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 47.77  E-value: 3.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370470618   3 RRRITSAARRSYVSSGemmvgGLAPGRRLGPGTRLSLARMPPPLPT-RVDFSLAGALNAGFKETR 66
Cdd:pfam04732  23 SSGSRSVSSRSYSRSS-----SSSPSSSSRRSSRSSSRSSYPSLAAdSLDFSLADALNQEFKATR 82
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
68-444 3.46e-124

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 365.40  E-value: 3.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  68 SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK---EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 145 AQDLATVRQKLQDETNLRLEAENNLAAYRQvrevegrgrggrkglmathpntapklsppeqcaaphcprrrgkarlrnge 224
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRK-------------------------------------------------- 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 225 kepgapvalysspllplqEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVA-KPDLTAAL 303
Cdd:pfam00038 111 ------------------DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSAL 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 304 KEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEE 383
Cdd:pfam00038 173 AEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEE 252

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370470618 384 RHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 444
Cdd:pfam00038 253 RYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 3-66 3.58e-07

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 47.77  E-value: 3.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370470618   3 RRRITSAARRSYVSSGemmvgGLAPGRRLGPGTRLSLARMPPPLPT-RVDFSLAGALNAGFKETR 66
Cdd:pfam04732  23 SSGSRSVSSRSYSRSS-----SSSPSSSSRRSSRSSSRSSYPSLAAdSLDFSLADALNQEFKATR 82
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 242-444 2.79e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 242 QEADEATLARLDLERKIESLEEEIRFL---RKIHEEEVRELQEQLARQQVHVELDVAKpdLTAALKEIRTQYEAMASSNM 318
Cdd:COG1196   281 LELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAELEEELEELEEE--LEELEEELEEAEEELEEAEA 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 319 HEAEEwyRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALAR 398
Cdd:COG1196   359 ELAEA--EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE 436

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370470618 399 LEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 444
Cdd:COG1196   437 EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL 482
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 56-420 3.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618   56 GALNAGFKETRAS---ERAEMMELNDRFASYIEKVRFLEQ-------QNKALAAELNQLRAKEPTKLADVY--QAELREL 123
Cdd:TIGR02168  659 GVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKalaelrkELEELEEELEQLRKELEELSRQISalRKDLARL 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRGGRkglmathpntapklspp 203
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKAL----------------- 801

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  204 eqcaaphcprRRGKARLRNGEKEPGApvalysspllplqEADEATLARLDLERKIESLEEEIRFLRKIHE---EEVRELQ 280
Cdd:TIGR02168  802 ----------REALDELRAELTLLNE-------------EAANLRERLESLERRIAATERRLEDLEEQIEelsEDIESLA 858

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  281 EQLARQQvhVELDVAKPDLTAALKEIRTQYEAmassnMHEAEEWYRSKFADLTDAAARNAEL---LRQAKHEANDYRRQL 357
Cdd:TIGR02168  859 AEIEELE--ELIEELESELEALLNERASLEEA-----LALLRSELEELSEELRELESKRSELrreLEELREKLAQLELRL 931

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370470618  358 QSLTCDLESLRGT-NESLERQMREQEERHVREAASYQEALARLEEEGQSLK-----DEMArhLQEYQDL 420
Cdd:TIGR02168  932 EGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKelgpvNLAA--IEEYEEL 998
46 PHA02562
endonuclease subunit; Provisional
 231-416 1.34e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.15  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 231 VALYSSPLLPLQEADEATLARLdlERKIESLEEEIrflrKIHEEEVRELQEQLArqqvhvELDVAKPDLTAALKEIRTQY 310
Cdd:PHA02562  197 IKTYNKNIEEQRKKNGENIARK--QNKYDELVEEA----KTIKAEIEELTDELL------NLVMDIEDPSAALNKLNTAA 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 311 EAMAS----------------------SNMHEAEEwyrsKFADLTDAAARNAELLRQAK----------HEANDYRRQLQ 358
Cdd:PHA02562  265 AKIKSkieqfqkvikmyekggvcptctQQISEGPD----RITKIKDKLKELQHSLEKLDtaideleeimDEFNEQSKKLL 340

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370470618 359 SLTCDLESLRGTNESLERQMREQE---ERHVREAASYQEALARLEEEGQSLKDEMARHLQE 416
Cdd:PHA02562  341 ELKNKISTNKQSLITLVDKAKKVKaaiEELQAEFVDNAEELAKLQDELDKIVKTKSELVKE 401
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
68-444 3.46e-124

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 365.40  E-value: 3.46e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  68 SERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK---EPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 145 AQDLATVRQKLQDETNLRLEAENNLAAYRQvrevegrgrggrkglmathpntapklsppeqcaaphcprrrgkarlrnge 224
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRK-------------------------------------------------- 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 225 kepgapvalysspllplqEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVA-KPDLTAAL 303
Cdd:pfam00038 111 ------------------DLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEMDAArKLDLTSAL 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 304 KEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEE 383
Cdd:pfam00038 173 AEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEE 252

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370470618 384 RHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 444
Cdd:pfam00038 253 RYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 3-66 3.58e-07

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 47.77  E-value: 3.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370470618   3 RRRITSAARRSYVSSGemmvgGLAPGRRLGPGTRLSLARMPPPLPT-RVDFSLAGALNAGFKETR 66
Cdd:pfam04732  23 SSGSRSVSSRSYSRSS-----SSSPSSSSRRSSRSSSRSSYPSLAAdSLDFSLADALNQEFKATR 82
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 242-444 2.79e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 242 QEADEATLARLDLERKIESLEEEIRFL---RKIHEEEVRELQEQLARQQVHVELDVAKpdLTAALKEIRTQYEAMASSNM 318
Cdd:COG1196   281 LELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAELEEELEELEEE--LEELEEELEEAEEELEEAEA 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 319 HEAEEwyRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALAR 398
Cdd:COG1196   359 ELAEA--EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE 436

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370470618 399 LEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 444
Cdd:COG1196   437 EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL 482
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 56-420 3.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618   56 GALNAGFKETRAS---ERAEMMELNDRFASYIEKVRFLEQ-------QNKALAAELNQLRAKEPTKLADVY--QAELREL 123
Cdd:TIGR02168  659 GVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKalaelrkELEELEEELEQLRKELEELSRQISalRKDLARL 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  124 RLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRGGRkglmathpntapklspp 203
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKAL----------------- 801

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  204 eqcaaphcprRRGKARLRNGEKEPGApvalysspllplqEADEATLARLDLERKIESLEEEIRFLRKIHE---EEVRELQ 280
Cdd:TIGR02168  802 ----------REALDELRAELTLLNE-------------EAANLRERLESLERRIAATERRLEDLEEQIEelsEDIESLA 858

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  281 EQLARQQvhVELDVAKPDLTAALKEIRTQYEAmassnMHEAEEWYRSKFADLTDAAARNAEL---LRQAKHEANDYRRQL 357
Cdd:TIGR02168  859 AEIEELE--ELIEELESELEALLNERASLEEA-----LALLRSELEELSEELRELESKRSELrreLEELREKLAQLELRL 931

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370470618  358 QSLTCDLESLRGT-NESLERQMREQEERHVREAASYQEALARLEEEGQSLK-----DEMArhLQEYQDL 420
Cdd:TIGR02168  932 EGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKelgpvNLAA--IEEYEEL 998
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 244-445 5.93e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 5.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  244 ADEATLARLDLERKIESLEEEIRFLrkihEEEVRELQEQLAR-QQVHVELDVAKPDLTAALKEIRTQYEAMassnmheae 322
Cdd:TIGR02168  665 SAKTNSSILERRREIEELEEKIEEL----EEKIAELEKALAElRKELEELEEELEQLRKELEELSRQISAL--------- 731

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  323 ewyRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERhvreAASYQEALARLEEE 402
Cdd:TIGR02168  732 ---RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ----IEQLKEELKALREA 804

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1370470618  403 GQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRI 445
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 85-443 6.37e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 6.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  85 EKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLE 164
Cdd:COG1196   213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 165 AENNLAAYRQVrevegrgrggrkglmathpntapklsppeqcaaphcpRRRGKARLRNGEkepgapvalysspllplQEA 244
Cdd:COG1196   293 LLAELARLEQD-------------------------------------IARLEERRRELE-----------------ERL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 245 DEATLARLDLERKIESLEEEIRFLrkihEEEVRELQEQLARQQVHVEldvakpDLTAALKEIRTQYEAMASsnmhEAEEW 324
Cdd:COG1196   319 EELEEELAELEEELEELEEELEEL----EEELEEAEEELEEAEAELA------EAEEALLEAEAELAEAEE----ELEEL 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 325 YRSKFADLTDAAARNAELLRQAKHEANDYRRQLQsltcdLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQ 404
Cdd:COG1196   385 AEELLEALRAAAELAAQLEELEEAEEALLERLER-----LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1370470618 405 SLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEEN 443
Cdd:COG1196   460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-436 3.99e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  242 QEADEATLARLDLERKIESLEEEIRFLRKIHEE---EVRELQEQLAR-----QQVHVELDVAKPDLTAALKEIRTQYEAM 313
Cdd:TIGR02168  691 EKIAELEKALAELRKELEELEEELEQLRKELEElsrQISALRKDLARleaevEQLEERIAQLSKELTELEAEIEELEERL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  314 ASSNMHEAE-----EWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVRE 388
Cdd:TIGR02168  771 EEAEEELAEaeaeiEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL 850

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370470618  389 A----------ASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRK 436
Cdd:TIGR02168  851 SedieslaaeiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELES 908
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 117-446 8.64e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  117 QAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRggrkglmathpnt 196
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERI------------- 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  197 apklsppeqcaaphcpRRRGKARLRNGEKEPGApvalysspllpLQEADEATLARLDLERKIESLEEEIRFLR---KIHE 273
Cdd:TIGR02168  750 ----------------AQLSKELTELEAEIEEL-----------EERLEEAEEELAEAEAEIEELEAQIEQLKeelKALR 802

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  274 EEVRELQEQLARQQVHV------------ELDVAKPDLTAALKEIRTQYEAMASSNmHEAEEwYRSKFADLTDAAARNAE 341
Cdd:TIGR02168  803 EALDELRAELTLLNEEAanlrerleslerRIAATERRLEDLEEQIEELSEDIESLA-AEIEE-LEELIEELESELEALLN 880

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  342 LLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHvreaASYQEALARLEEEGQSLKDEMArhlQEYQDLL 421
Cdd:TIGR02168  881 ERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL----AQLELRLEGLEVRIDNLQERLS---EEYSLTL 953

                          330       340
                   ....*....|....*....|....*
gi 1370470618  422 NVKLALDIEIATYRKLLEGEENRIT 446
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLE 978
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 67-412 1.14e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618   67 ASERAEMMELNDRFASyiekvrfLEQQNKALAAELNQL--RAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Cdd:TIGR02169  670 RSEPAELQRLRERLEG-------LKRELSSLQSELRRIenRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEEL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  145 AQDLATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRGGRKGLMATH--PNTAPKLSPPEQcaaphcPRRRGKARLRN 222
Cdd:TIGR02169  743 EEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSriPEIQAELSKLEE------EVSRIEARLRE 816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  223 GEKEPGApvalySSPLLPLQEADEATLA--RLDLERKIESLEEEIRFLRKiheeEVRELQEQLARQQVHV-ELDVAKPDL 299
Cdd:TIGR02169  817 IEQKLNR-----LTLEKEYLEKEIQELQeqRIDLKEQIKSIEKEIENLNG----KKEELEEELEELEAALrDLESRLGDL 887

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  300 TAALKEIRTQYEAMaSSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTC--DLESLRGTNESLERQ 377
Cdd:TIGR02169  888 KKERDELEAQLREL-ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEelSLEDVQAELQRVEEE 966

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1370470618  378 MR----------EQEERHVREAASYQEALARLEEEGQSLKDEMAR 412
Cdd:TIGR02169  967 IRalepvnmlaiQEYEEVLKRLDELKEKRAKLEEERKAILERIEE 1011
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-427 1.95e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 1.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  242 QEADEATLARLDLERKIESLEEEIRFLRK------IHEEEVRELQEQLARQQVHVELDVAkpDLTAALKEIRTQYEAMAs 315
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLEQQKQILRErlanleRQLEELEAQLEELESKLDELAEELA--ELEEKLEELKEELESLE- 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  316 snmhEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEA 395
Cdd:TIGR02168  358 ----AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA 433

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1370470618  396 LARLEEEGQSLKDEMARHLQEYQDLLNVKLAL 427
Cdd:TIGR02168  434 ELKELQAELEELEEELEELQEELERLEEALEE 465
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
255-446 2.29e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 2.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  255 ERKIESLEEEIRFLrkihEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASsnmheAEEWYRSKFADLTD 334
Cdd:COG4913    609 RAKLAALEAELAEL----EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAS-----AEREIAELEAELER 679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  335 AAARNAElLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHL 414
Cdd:COG4913    680 LDASSDD-LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAA 758

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1370470618  415 QEYQDLLNVKLALDIEIATYRKLLEGEENRIT 446
Cdd:COG4913    759 LGDAVERELRENLEERIDALRARLNRAEEELE 790
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 249-445 2.99e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 249 LARLD-----LERKIESLEEE----IRFLRKIHEEEVRELQEQLAR-QQVHVELDVAKPDLTAALKEIRTQYEAMASSNM 318
Cdd:COG1196   188 LERLEdilgeLERQLEPLERQaekaERYRELKEELKELEAELLLLKlRELEAELEELEAELEELEAELEELEAELAELEA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 319 HEAEEwyRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVR---EAASYQEA 395
Cdd:COG1196   268 ELEEL--RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEEleeELEELEEE 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1370470618 396 LARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRI 445
Cdd:COG1196   346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA 395
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 242-436 3.17e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 242 QEADEATLARLDLERKIESLEEEIRFLrkihEEEVRELQEQLARQQVHVEldvakpDLTAALKEIRTQYEAMASSNMHEA 321
Cdd:COG4942    48 KEEKALLKQLAALERRIAALARRIRAL----EQELAALEAELAELEKEIA------ELRAELEAQKEELAELLRALYRLG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 322 EEWY------RSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVR---EAASY 392
Cdd:COG4942   118 RQPPlalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAAleaLKAER 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1370470618 393 QEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRK 436
Cdd:COG4942   198 QKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 242-418 3.74e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 3.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  242 QEADEATLARLDLERKIESLEEEIRFLRKiHEEEVRELQEQLARQQvhVELDVAKPDLTAALKEIRTQYEAmassnMHEA 321
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQ-EEEKLKERLEELEEDL--SSLEQEIENVKSELKELEARIEE-----LEED 773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  322 EEWYRSKFADLTDAAARN-----AELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERhVREAASYQEAL 396
Cdd:TIGR02169  774 LHKLEEALNDLEARLSHSripeiQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQ-RIDLKEQIKSI 852

                          170       180
                   ....*....|....*....|..
gi 1370470618  397 ARLEEEGQSLKDEMARHLQEYQ 418
Cdd:TIGR02169  853 EKEIENLNGKKEELEEELEELE 874
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
241-430 6.10e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 6.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  241 LQEADEATLARLDLERKIESLEEEIRFLRkiheEEVRELQEQLARQQVHVEldvakpDLTAALKEIRTQYEAMASSNMHE 320
Cdd:COG4913    273 ELEYLRAALRLWFAQRRLELLEAELEELR----AELARLEAELERLEARLD------ALREELDELEAQIRGNGGDRLEQ 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  321 AE---EWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALA 397
Cdd:COG4913    343 LEreiERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELR 422

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1370470618  398 RLEEEGQSL---KDEMARHLQEYQDLLNVKLALDIE 430
Cdd:COG4913    423 ELEAEIASLerrKSNIPARLLALRDALAEALGLDEA 458
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
241-422 8.02e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 8.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  241 LQEADEATLARLDLERKIESLEEEIRFLRKIHeEEVRELQEQLarQQVHVELDVAKPDLTAALKEIRTqyeamASSNMHE 320
Cdd:COG4913    653 LAEYSWDEIDVASAEREIAELEAELERLDASS-DDLAALEEQL--EELEAELEELEEELDELKGEIGR-----LEKELEQ 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  321 AEEWYRSKFADLTDAAAR-------NAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVRE----- 388
Cdd:COG4913    725 AEEELDELQDRLEAAEDLarlelraLLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREwpaet 804

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1370470618  389 ---------AASYQEALARLEEEGqslkdeMARHLQEYQDLLN 422
Cdd:COG4913    805 adldadlesLPEYLALLDRLEEDG------LPEYEERFKELLN 841
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 63-351 9.46e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 9.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  63 KETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQA---------ELRELRLRLDQLTAN 133
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELlaelarleqDIARLEERRRELEER 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 134 SARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRGGRKGLMAthpntapklsppeqcaaphcPR 213
Cdd:COG1196   318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA--------------------EA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 214 RRGKARLRNGEKEPGAPVALYSSPLLPLQEADEATLARLD--LERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVE 291
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLErlEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 292 LDVAKPDLTAALKEIRTQYEAMASSNMHEAEEwyRSKFADLTDAAARNAELLRQAKHEAN 351
Cdd:COG1196   458 EEALLELLAELLEEAALLEAALAELLEELAEA--AARLLLLLEAEADYEGFLEGVKAALL 515
46 PHA02562
endonuclease subunit; Provisional
 231-416 1.34e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.15  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 231 VALYSSPLLPLQEADEATLARLdlERKIESLEEEIrflrKIHEEEVRELQEQLArqqvhvELDVAKPDLTAALKEIRTQY 310
Cdd:PHA02562  197 IKTYNKNIEEQRKKNGENIARK--QNKYDELVEEA----KTIKAEIEELTDELL------NLVMDIEDPSAALNKLNTAA 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 311 EAMAS----------------------SNMHEAEEwyrsKFADLTDAAARNAELLRQAK----------HEANDYRRQLQ 358
Cdd:PHA02562  265 AKIKSkieqfqkvikmyekggvcptctQQISEGPD----RITKIKDKLKELQHSLEKLDtaideleeimDEFNEQSKKLL 340

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370470618 359 SLTCDLESLRGTNESLERQMREQE---ERHVREAASYQEALARLEEEGQSLKDEMARHLQE 416
Cdd:PHA02562  341 ELKNKISTNKQSLITLVDKAKKVKaaiEELQAEFVDNAEELAKLQDELDKIVKTKSELVKE 401
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 54-173 1.52e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  54 LAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKLADVYQAELRELRLRLDQLT 131
Cdd:COG4942    10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaALARRIRALEQELAALEAELAELE 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1370470618 132 ANSARLEVERDNLAQDLATV-----RQKLQDETNLRLEAENNLAAYR 173
Cdd:COG4942    90 KEIAELRAELEAQKEELAELlralyRLGRQPPLALLLSPEDFLDAVR 136
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 253-444 2.32e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  253 DLERKIESLEEEIRFLRKIHEEEVRELQE--------QLARQQVHVELDVAKPDLTAALKEIRT--QYEAMASSNMHEAE 322
Cdd:TIGR02168  236 ELREELEELQEELKEAEEELEELTAELQEleekleelRLEVSELEEEIEELQKELYALANEISRleQQKQILRERLANLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  323 EWYRSKFADLTDAAARN---AELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEA---- 395
Cdd:TIGR02168  316 RQLEELEAQLEELESKLdelAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqi 395

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  396 ------LARLEEEGQSLKDEMARHLQEYQDLL-----NVKLALDIEIATYRKLLEGEENR 444
Cdd:TIGR02168  396 aslnneIERLEARLERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQEE 455
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 86-428 2.96e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  86 KVRFLEQQNKALAAELNQLRAKEptklaDVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEA 165
Cdd:COG1196   233 KLRELEAELEELEAELEELEAEL-----EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 166 ENNLAAYRQVREVEGRGrggrkglmathpntapklsppeqcaaphcpRRRGKARLRNGEkepgapvalysspllplQEAD 245
Cdd:COG1196   308 EERRRELEERLEELEEE------------------------------LAELEEELEELE-----------------EELE 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 246 EATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWY 325
Cdd:COG1196   341 ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE 420

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 326 RSKFADLTDAAARNAELLRQAKHEANDYRRQLQsltcdLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQS 405
Cdd:COG1196   421 EELEELEEALAELEEEEEEEEEALEEAAEEEAE-----LEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495

                         330       340
                  ....*....|....*....|...
gi 1370470618 406 LKDEMARHLQEYQDLLNVKLALD 428
Cdd:COG1196   496 LLEAEADYEGFLEGVKAALLLAG 518
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 241-445 3.32e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  241 LQEADEATLARLDLERKIESLEEEIRFLRK-IHEEEVRELQEQLARQQVHVEldvakpDLTAALKEIRTQYEAMAssnmh 319
Cdd:TIGR02169  203 LRREREKAERYQALLKEKREYEGYELLKEKeALERQKEAIERQLASLEEELE------KLTEEISELEKRLEEIE----- 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  320 eaeewyrskfADLTDAaarNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHV------------- 386
Cdd:TIGR02169  272 ----------QLLEEL---NKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAkleaeidkllaei 338

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370470618  387 ----REAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRI 445
Cdd:TIGR02169  339 eeleREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
63-433 8.07e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.98  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618  63 KETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEptkladvyqAELRELRLRLDQLTANSARLEVERD 142
Cdd:COG4717   110 ELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERL---------EELRELEEELEELEAELAELQEELE 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 143 NLAQDL-ATVRQKLQDETNLRLEAENNLAAYRQVREVEGRGRGGRKGLMATHPNTAPKLSPPEQCAAPHCPRRRGKARLR 221
Cdd:COG4717   181 ELLEQLsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLA 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 222 NGEKEPGAPVALYSSPLLPLQEADEATLARLDLERKIESLEEEIRFLRKI-HEEEVRELQEQLARQQVHVELDVAKPDLT 300
Cdd:COG4717   261 LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALpALEELEEEELEELLAALGLPPDLSPEELL 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370470618 301 AALKEIRTQYEAMASSNMHEAEewyrskfADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMRE 380
Cdd:COG4717   341 ELLDRIEELQELLREAEELEEE-------LQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEE 413

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1370470618 381 QEErhVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIAT 433
Cdd:COG4717   414 LLG--ELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQ 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH