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Conserved domains on  [gi|1370457564|ref|XP_024303886|]
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RPE-retinal G protein-coupled receptor isoform X1 [Homo sapiens]

Protein Classification

7tmA_Retinal_GPR domain-containing protein( domain architecture ID 11606770)

7tmA_Retinal_GPR domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
17-211 8.86e-115

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


:

Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 327.78  E-value: 8.86e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15072     1 FAVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSF 176
Cdd:cd15072    81 FTALASICSSAAIAWDRYHHYCTRSKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDRNYVSY 160
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 177 LFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQA 211
Cdd:cd15072   161 LFTMAFFNFILPLFILLTSYSSIEQKLKKEGHLRF 195
 
Name Accession Description Interval E-value
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
17-211 8.86e-115

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 327.78  E-value: 8.86e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15072     1 FAVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSF 176
Cdd:cd15072    81 FTALASICSSAAIAWDRYHHYCTRSKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDRNYVSY 160
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 177 LFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQA 211
Cdd:cd15072   161 LFTMAFFNFILPLFILLTSYSSIEQKLKKEGHLRF 195
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
34-203 2.67e-20

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 85.82  E-value: 2.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL--VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAW 111
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLpfWLVYYLLHGDWPFGSALCKLVGALFYVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 112 GRYH------HYCTRSQLAWnsAVSLVLFVWLSSAFWAALPLLGWGHYDY-EPLGTCCTLDYSKGDRNFTSFLFTMSFFN 184
Cdd:pfam00001  82 DRYLaivhplRYRRIRTPRR--AKVLILLVWVLALLLSLPPLLFGWTLTVpEGNVTVCFIDFPEVLSKPVSYTLLSSVLG 159
                         170
                  ....*....|....*....
gi 1370457564 185 FAMPLFITITSYSLMEQKL 203
Cdd:pfam00001 160 FLLPLLVILVCYTRIIRTL 178
 
Name Accession Description Interval E-value
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
17-211 8.86e-115

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 327.78  E-value: 8.86e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15072     1 FAVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSF 176
Cdd:cd15072    81 FTALASICSSAAIAWDRYHHYCTRSKLQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKGDRNYVSY 160
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 177 LFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQA 211
Cdd:cd15072   161 LFTMAFFNFILPLFILLTSYSSIEQKLKKEGHLRF 195
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
18-196 1.75e-49

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 162.38  E-value: 1.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd14969     2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYpLSFYSNLSGRWSFGDPGCVIYGFAVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQ---LAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNF 173
Cdd:cd14969    82 FLGLVSISTLAALAFERYLVIVRPLKafrLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYSKDPNS 161
                         170       180
                  ....*....|....*....|...
gi 1370457564 174 TSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd14969   162 LSYIVSLFVFCFFLPLAIIIFCY 184
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
19-196 8.84e-37

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 129.47  E-value: 8.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15073     3 VAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYpFSAASDLHGSWKFGYAGCQWYAFLNIF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRYHHYC---TRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFT 174
Cdd:cd15073    83 FGMASIGLLTVVAVDRYLTICrpdLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSSFV 162
                         170       180
                  ....*....|....*....|..
gi 1370457564 175 SFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15073   163 SYTMSVIVVNFIVPLAVMFYCY 184
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
17-197 1.20e-35

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 126.68  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15083     1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCiLNCPLMVISSFSGRWIFGKTGCDMYGFSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15083    81 GLFGIMSINTLAAIAVDRYlvitRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFDYLSRDD 160
                         170       180
                  ....*....|....*....|....*.
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15083   161 ANRSYVICLLIFGFVLPLLIIIYCYS 186
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
17-206 1.22e-32

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 118.92  E-value: 1.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15074     1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYpLAIISAFAHRWLFGDIGCVFYGFCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSK--GD 170
Cdd:cd15074    81 FLFGCCSINTLTAISIYRYLKICHppyGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGasAS 160
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370457564 171 RNFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKS 206
Cdd:cd15074   161 VGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSS 196
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
18-196 1.46e-31

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 116.27  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAAT-SSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15337     2 LIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAvNGFPLKTiSSFNKKWIWGKVACELYGFAG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15337    82 GIFGFMSITTLAAISIDRYlviaKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDYLSRDL 161
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15337   162 NNRLFILGLFIFGFLCPLLIIIFCY 186
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
34-197 1.03e-28

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 108.82  E-value: 1.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGR 113
Cdd:cd15079    18 NGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 114 YH--------HYCTRSQlawnsAVSLVLFVWLSSAFWAALPLL-GWGHYDYEPLGTCCTLDYSKGDRNFTSFLFTMSFFN 184
Cdd:cd15079    98 YNvivkplngNPLTRGK-----ALLLILFIWLYALPWALLPLLfGWGRYVPEGFLTSCSFDYLTRDWNTRSFVATIFVFA 172
                         170
                  ....*....|...
gi 1370457564 185 FAMPLFITITSYS 197
Cdd:cd15079   173 YVIPLIIIIYCYS 185
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
19-199 9.83e-27

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 103.26  E-value: 9.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15336     3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLtQSPIFFVNSLHKRWIFGEKGCELYAFCGAL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRYHhYCTRSQLA--WNS---AVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDY---SKG 169
Cdd:cd15336    83 FGITSMITLLAISLDRYL-VITKPLASirWVSkkrAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLLTSCTWDYmtfTPS 161
                         170       180       190
                  ....*....|....*....|....*....|
gi 1370457564 170 DRNFTSFLFtmsFFNFAMPLFITITSYSLM 199
Cdd:cd15336   162 VRAYTMLLF---CFVFFIPLGIIIYCYLFI 188
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
22-206 1.97e-26

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 102.37  E-value: 1.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAATSSLLRRWPYGSDGCQAHGFQGFVTAL 100
Cdd:cd00637     4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLlVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 101 ASICSSAAIAWGRY------HHYctRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNft 174
Cdd:cd00637    84 ASILTLTAISVDRYlaivhpLRY--RRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK-- 159
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370457564 175 SFLFTMSFFNFAMPLFITITSYSLMEQKLGKS 206
Cdd:cd00637   160 AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRH 191
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
19-199 2.96e-21

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 88.39  E-value: 2.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd14967     2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMpFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRY------HHYctRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTC-CTLDYSKGd 170
Cdd:cd14967    82 CCTASILNLCAISLDRYlaitrpLRY--RQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCeCEFTPNKI- 158
                         170       180
                  ....*....|....*....|....*....
gi 1370457564 171 rnftsFLFTMSFFNFAMPLFITITSYSLM 199
Cdd:cd14967   159 -----YVLVSSVISFFIPLLIMIVLYARI 182
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
34-203 2.67e-20

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 85.82  E-value: 2.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL--VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAW 111
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLpfWLVYYLLHGDWPFGSALCKLVGALFYVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 112 GRYH------HYCTRSQLAWnsAVSLVLFVWLSSAFWAALPLLGWGHYDY-EPLGTCCTLDYSKGDRNFTSFLFTMSFFN 184
Cdd:pfam00001  82 DRYLaivhplRYRRIRTPRR--AKVLILLVWVLALLLSLPPLLFGWTLTVpEGNVTVCFIDFPEVLSKPVSYTLLSSVLG 159
                         170
                  ....*....|....*....
gi 1370457564 185 FAMPLFITITSYSLMEQKL 203
Cdd:pfam00001 160 FLLPLLVILVCYTRIIRTL 178
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
30-196 1.99e-18

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 81.03  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR-RWPYGSDGCQAHGFQGFVTALASICSSAA 108
Cdd:cd15078    14 GVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRgRWVFDVAGCVWDGFSNSLFGIVSIMTLTV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 109 IAWGRY----HHYCTRSQLAWNSavslVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSFLFTMSFFN 184
Cdd:cd15078    94 LAYERYirvvHAKVVNFSWSWRA----ITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPNDTSFVLLFFLGC 169
                         170
                  ....*....|..
gi 1370457564 185 FAMPLFITITSY 196
Cdd:cd15078   170 LVVPLGIMAYCY 181
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
16-197 1.80e-14

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 70.19  E-value: 1.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLveALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAATSSLLRRWPYGSDGCQAHGFQ 94
Cdd:cd15075     2 ILSIIMAVF--SIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVfGGLLSVVTNAVGYFNLGRVGCVLEGFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15075    80 VAFFGIAALCTVAVIAVDRLFVVCKplgTLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVMTSCAPDWYSRDP 159
                         170       180
                  ....*....|....*....|....*.
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15075   160 VNVSYILCYFSFCFAIPFAIILVSYG 185
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
17-196 3.37e-14

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 69.38  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15086     1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTpFSFAASTQGRWLIGEHGCRWYGFAN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHY--CTRSQLA-WNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRN 172
Cdd:cd15086    81 SLFGIVSLISLAVLSYERYCTLlrPTEADVSdYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRSAN 160
                         170       180
                  ....*....|....*....|....
gi 1370457564 173 FTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15086   161 SISYIICLFIFCLLLPFLVMVYCY 184
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
22-197 1.57e-13

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 67.57  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPY-GSDGCQAHGFQGFVTAL 100
Cdd:cd15085     6 LMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYlGDAFCIFQGFAVNYFGI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 101 ASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSFL 177
Cdd:cd15085    86 VSLWSLTLLAYERYNVVCKpmgGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYL 165
                         170       180
                  ....*....|....*....|
gi 1370457564 178 FTMSFFNFAMPLFITITSYS 197
Cdd:cd15085   166 ILYFLMCFVIPVAIIGFSYG 185
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
17-197 4.59e-13

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 66.42  E-value: 4.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15084    11 LTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLfGSSVSFSNNIVGFFVFGKTMCEFEGFMV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYCTRS---QLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRN 172
Cdd:cd15084    91 SLTGIVGLWSLAILAFERYLVICKPMgdfRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCGPNWYTGGTN 170
                         170       180
                  ....*....|....*....|....*
gi 1370457564 173 FTSFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15084   171 NNSYILALFVTCFALPLSTIIFSYS 195
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
16-210 3.06e-12

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 64.05  E-value: 3.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMvLLVEALSgLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPY-GSDGCQAHGFQ 94
Cdd:cd15082    15 VLAALM-FVVTSLS-LAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFlGVWACVLEGFA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15082    93 VTFFGIVALWSLAVLAFERFFVICRplgNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNM 172
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ 210
Cdd:cd15082   173 HDHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQ 211
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-196 6.59e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 62.76  E-value: 6.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15061    17 NLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLpLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLD 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 113 RY-------HHYCTRSQlawNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCtLDYSKGDRNFTSFLftmSFFnf 185
Cdd:cd15061    97 RYfaityplKYRTKRSR---RLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCY-YTYDKGYRIYSSMG---SFF-- 167
                         170
                  ....*....|.
gi 1370457564 186 aMPLFITITSY 196
Cdd:cd15061   168 -LPLLLMLFVY 177
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
22-206 1.87e-11

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 61.54  E-value: 1.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQGFVTAL 100
Cdd:cd15390     9 VMVLVAIGG---NLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISaFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 101 ASICSSAAIAWGRYHH--YCTRSQLAWNSAVSLVLFVWLSSAFWaALPLLGWG-----HYDYEPLGTCCTLDYSKGDRNF 173
Cdd:cd15390    86 ASVFTLMAISIDRYIAivHPLRPRLSRRTTKIAIAVIWLASFLL-ALPQLLYSttetyYYYTGSERTVCFIAWPDGPNSL 164
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 174 TSFLFTMSFF--NFAMPLFITITSYSLMEQKLGKS 206
Cdd:cd15390   165 QDFVYNIVLFvvTYFLPLIIMAVAYTRVGVELWGS 199
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
17-196 2.35e-11

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 61.39  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVeaLSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15080     3 LAAYMFLLI--LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFtTTMYTSMHGYFVFGPTGCNLEGFFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYC---TRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYS--KGD 170
Cdd:cd15080    81 TLGGEIALWSLVVLAIERYVVVCkpmSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYtlKPE 160
                         170       180
                  ....*....|....*....|....*.
gi 1370457564 171 RNFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15080   161 VNNESFVIYMFVVHFTIPLIVIFFCY 186
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
18-202 3.10e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 60.74  E-value: 3.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALsGLSLNTLTIFSFCKTPELRTPCHLLVLSLALAD-SGISLNALVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15210     3 AAVWGIVFMVV-GVPGNLLTVLALLRSKKLRTRTNAFIINLSISDlLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLG-WGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15210    82 GLVAVSLLTLVLITLNRYiliaHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCSCSILRDKKGR 161
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370457564 172 NFTSFLFtmsFFNFAMPLFITITSYSLMEQK 202
Cdd:cd15210   162 SPKTFLF---VFGFVLPCLVIIICYARREDR 189
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-205 9.16e-11

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 59.93  E-value: 9.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGF-QGfVTALASICS 105
Cdd:cd15203    12 VLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLpFTLIYTLTKNWPFGSILCKLVPSlQG-VSIFVSTLT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 106 SAAIAWGRYHH--YCTRSQLAWNSAVSLVLFVWLSSAFwAALPLL---GWGHYDYEPLGTC---CTLDY-SKGDRnftsF 176
Cdd:cd15203    91 LTAIAIDRYQLivYPTRPRMSKRHALLIIALIWILSLL-LSLPLAifqELSDVPIEILPYCgyfCTESWpSSSSR----L 165
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370457564 177 LFTMS--FFNFAMPLFITITSYSLMEQKLGK 205
Cdd:cd15203   166 IYTISvlVLQFVIPLLIISFCYFRISLKLRK 196
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
18-196 1.74e-10

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 58.76  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR-WPYGSDGCQAHGFQGF 96
Cdd:cd15402     2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNgWNLGYLHCQISGFLMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQ----LAWNSAVSLVLFVWLSSaFWAALPLLGWGHYDYEPLGTCCTLDYSKGdrn 172
Cdd:cd15402    82 LSVIGSIFNITGIAINRYCYICHSLKydklYSDKNSLCYVLLIWVLT-VAAIVPNLFVGSLQYDPRIYSCTFAQSVS--- 157
                         170       180
                  ....*....|....*....|....
gi 1370457564 173 fTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15402   158 -SAYTIAVVFFHFILPIIIVTFCY 180
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
16-196 8.00e-10

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 57.22  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVEAlsGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNA-LVAATSSLLRRWPYGSDGCQAHGFQ 94
Cdd:cd15081    14 LTSVWMIFVVFA--SVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIAsTISVVNQIFGYFILGHPMCVLEGFT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKG-- 169
Cdd:cd15081    92 VSVCGITGLWSLTIISWERWVVVCKpfgNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGss 171
                         170       180
                  ....*....|....*....|....*..
gi 1370457564 170 DRNFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15081   172 DPGVQSYMIVLMITCCIIPLAIIILCY 198
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
18-207 1.35e-09

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 56.53  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd14970     5 AVYSVVCVVGLTG---NSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRYHHYC-TRSQLAWNS---AVSLVLFVWLSSA------FWAAlpllgwGHYDYEPLGTCCTL--- 164
Cdd:cd14970    82 NMFTSIFCLTVMSVDRYLAVVhPVKSLRFRTprkAKLVSLCVWALSLvlglpvIIFA------RTLQEEGGTISCNLqwp 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1370457564 165 -DYSKGDRNFTSFLFtmsFFNFAMPLFITITSYSLMEQKLGKSG 207
Cdd:cd14970   156 dPPDYWGRVFTIYTF---VLGFAVPLLVITVCYSLIIRRLRSSR 196
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
18-196 7.43e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 54.40  E-value: 7.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR-WPYGSDGCQAHGFQGF 96
Cdd:cd15209     2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNgWTLGQLHCQASGFIMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYCTRSQL-----AWNSAVSLVLfVWLSSAFwAALPLLGWGHYDYEPLGTCCTLDYSkgdr 171
Cdd:cd15209    82 LSVIGSIFNITAIAINRYCYICHSLQYdrlysLRNTCCYLCL-TWLLTVL-AVLPNFFIGSLQYDPRIYSCTFAQT---- 155
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15209   156 VSTVYTITVVVIHFLLPLLIVSFCY 180
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
19-161 1.34e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 53.49  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADsgISLNALV---AATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15064     3 ISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVAD--LLVAVLVmplSAVYELTGRWILGQVLCDIWISLD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370457564  96 FVTALASICSSAAIAWGRYH------HYcTRSQLAwNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTC 161
Cdd:cd15064    81 VTCCTASILHLCVIALDRYWaitdavEY-AHKRTP-KRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSEC 150
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
18-198 2.15e-08

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 53.08  E-value: 2.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15048     2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMpFYIPYTLTGKWPFGKVFCKAWLVVDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRY------HHYctRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGH---YDYEPLGTCctldYS 167
Cdd:cd15048    82 TLCTASALTIVLISLDRYlsvtkaVKY--RAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLwtgYSIVPTGDC----EV 155
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370457564 168 KGDRNFTsFLFTMSFFNFAMPLFITITSYSL 198
Cdd:cd15048   156 EFFDHFY-FTFITSVLEFFIPFISVSFFNLL 185
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
28-203 3.54e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 52.22  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGF-QGfVTALASICS 105
Cdd:cd14993    12 LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMpLTLLENVYRPWVFGEVLCKAVPYlQG-VSVSASVLT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 106 SAAIAWGRYHHYC----TRSQLAWNSAVSLVLFVWLSSAFwAALPLL-------GWGHYDYEPLGTCCTLDYSKG--DRN 172
Cdd:cd14993    91 LVAISIDRYLAICyplkARRVSTKRRARIIIVAIWVIAII-IMLPLLvvyeleeIISSEPGTITIYICTEDWPSPelRKA 169
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370457564 173 FTSFLFTMSFFnfaMPLFITITSYSLMEQKL 203
Cdd:cd14993   170 YNVALFVVLYV---LPLLIISVAYSLIGRRL 197
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
16-197 3.66e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 52.35  E-value: 3.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLnaLV---AATSSLLRRWPYGSDGCQAhg 92
Cdd:cd15065     2 IGIFLSLIIVLAIFG---NVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVAL--LVmtfAVVNDLLGYWLFGETFCNI-- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQGF--VTALASICSSAAIAWGR---------YHHYCTRSQlawnsAVSLVLFVWLSSAFWAALPL-LGWgHYDYEPLGT 160
Cdd:cd15065    75 WISFdvMCSTASILNLCAISLDRyihikkplkYERWMTTRR-----ALVVIASVWILSALISFLPIhLGW-HRLSQDEIK 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1370457564 161 CCTLDYSKG-----DRNFTSFLFTmSFFNFAMPLFITITSYS 197
Cdd:cd15065   149 GLNHASNPKpscalDLNPTYAVVS-SLISFYIPCLVMLLIYS 189
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
14-197 5.69e-08

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 51.74  E-value: 5.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  14 LEVLAVGMVLLVealsGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAA-TSSLLRRWPYGSDGCQAHG 92
Cdd:cd15076     2 LQAAFMGFVFIV----GTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVfVASAQGYFFFGRTVCALEA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQGFVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLD-YSK 168
Cdd:cd15076    78 FVGSLAGLVTGWSLAFLAFERYIVICKpfgNFRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLQCSCGPDwYTV 157
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370457564 169 GDR----NFTSFLFtmsFFNFAMPLFITITSYS 197
Cdd:cd15076   158 GTKyrseYYTWFLF---IFCFIVPLSIIIFSYS 187
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
19-151 8.69e-08

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 51.12  E-value: 8.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15329     3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMpLAIIYELSGYWPFGEILCDVWISFDVL 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRY------HHYCTRSQLAwnSAVSLVLFVWLSSAFWAALPLLGWG 151
Cdd:cd15329    83 LCTASILNLCAISVDRYlvitrpLTYAVKRTPK--RMALMIAIVWLLSALISIPPLFGWK 140
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
16-197 1.29e-07

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 50.60  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVeaLSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRW-PYGSDGCQAHGFQ 94
Cdd:cd15077     2 GMSAFMLFLV--IAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYfVLGPLACKIEGFT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYHHYCT---RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 171
Cdd:cd15077    80 ATLGGMVSLWSLAVVAFERFLVICKplgNFTFRGTHAIIGCIATWVFGLAASLPPLFGWSRYIPEGLQCSCGPDWYTTNN 159
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370457564 172 NFTS-----FLFTmsfFNFAMPLFITITSYS 197
Cdd:cd15077   160 KWNNesyvmFLFC---FCFGVPLSIIVFSYG 187
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
17-196 1.94e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 49.91  E-value: 1.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15327     1 VGVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLpFSATLEVLGFWAFGRVFCDIWAAVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHyDYEPLGTCCTLDYSKGDR 171
Cdd:cd15327    81 VLCCTASILSLCVISVDRYvgvkHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKE-PPPPDESICSITEEPGYA 159
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 NFTsflftmSFFNFAMPLFITITSY 196
Cdd:cd15327   160 LFS------SLFSFYLPLMVILVMY 178
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
28-203 2.25e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 50.05  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLL--RRWPYGSDGCQAHGFQGFVTALASICS 105
Cdd:cd14979    12 VVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwqYPWAFGDGGCKLYYFLFEACTYATVLT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 106 SAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSaFWAALPLLGWGHYDY--------EPLGTCCTLdySKGDRNF 173
Cdd:cd14979    92 IVALSVERYvaicHPLKAKTLVTKRRVKRFILAIWLVS-ILCAIPILFLMGIQYlngplpgpVPDSAVCTL--VVDRSTF 168
                         170       180       190
                  ....*....|....*....|....*....|
gi 1370457564 174 TSFLFTMSFFNFAMPLFITITSYSLMEQKL 203
Cdd:cd14979   169 KYVFQVSTFIFFVLPMFVISILYFRIGVKL 198
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
18-148 2.33e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 49.91  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADsgISLNALV---AATSSLLRRWPYGSDGCQAHGFQ 94
Cdd:cd15959     2 LAGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACAD--LVMGLLVvppGATILLTGHWPLGTTVCELWTSV 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYhhYCTRSQLAWNSAVS------LVLFVWLSSAFWAALPLL 148
Cdd:cd15959    80 DVLCVTASIETLCAIAVDRY--LAITNPLRYEALVTkrrartAVCLVWAISAAISFLPIM 137
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-206 3.83e-07

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 49.39  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSS 106
Cdd:cd14971    12 LLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVpFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 107 AAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAA--LPLLGWGHYDYEPLgTCCTLDYSKGDRNFTSFLFTM 180
Cdd:cd14971    92 VAMSLDRFlavvYPLRSLHIRTPRNALAASGCIWVVSLAVAApvLALHRLRNYTPGNR-TVCSEAWPSRAHRRAFALCTF 170
                         170       180
                  ....*....|....*....|....*.
gi 1370457564 181 sFFNFAMPLFITITSYSLMEQKLGKS 206
Cdd:cd14971   171 -LFGYLLPLLLICVCYAAMLRHLWRV 195
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
17-150 8.21e-07

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 48.35  E-value: 8.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15326     1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLpFSATLEILGYWVFGRIFCDIWAAVD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGW 150
Cdd:cd15326    81 VLCCTASILSLCAISIDRYigvrHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGW 139
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
45-196 9.98e-07

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 47.75  E-value: 9.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  45 PELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTR-SQ 122
Cdd:cd15213    29 PAMRSAINLLLANLAFSDIMLSLVCMpFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRqDK 108
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370457564 123 LAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDY--SKGDRNFTSFLFTMSFFnfaMPLFITITSY 196
Cdd:cd15213   109 LNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYteSPADRIYVVLLLVAVFF---IPFLIMLYSY 181
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
48-186 1.24e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 47.63  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  48 RTPCHLLVLSLALAD-SGISLN-ALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRY----HHYcTRS 121
Cdd:cd14981    34 WSVFYRLVAGLAITDlLGILLTsPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFlaitHPF-FYN 112
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370457564 122 QLAWNSAVSLVLF-VWLSSAFWAALPLLGWGHYDYEPLGTCCTLDY---SKGDRNFTSF--------LFTMSFFNFA 186
Cdd:cd14981   113 SHVKKRRARLMLGaVWAFALLIASLPLLGLGSYVLQYPGTWCFLDFyskNTGDAAYAYLysilglliLLVTLLCNLL 189
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-199 1.36e-06

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 47.62  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSglslNTLTIFSFCKTPELRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd16003     5 LAYGFVVAVAVFG----NLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAaFNTLINFIYALHSEWYFGEAYCRFHNFFP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYC--TRSQLAWNSAVSLVLFVWlSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNF 173
Cdd:cd16003    81 ITSVFASIYSMTAIAVDRYMAIIdpLKPRLSATATKVVIGSIW-ILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGPDQH 159
                         170       180
                  ....*....|....*....|....*.
gi 1370457564 174 TSFLFTMSFFNFAMPLFITITSYSLM 199
Cdd:cd16003   160 FTYHIIVIVLVYCLPLLVMGITYTIV 185
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
16-203 1.44e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 47.64  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15091     3 ITAVYSVVFVVGLVG---NSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISID 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYCT-------RSQLawnSAVSLVLFVW-LSSAFWAALPLLGWGHYDYEPLGTCCTLDYS 167
Cdd:cd15091    80 YYNMFTSIFTLTMMSVDRYIAVCHpvkaldfRTPL---KAKIINICIWlLSSSVGISAIVLGGTKVREDVDSTECSLQFP 156
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370457564 168 KGDRNFTSFLFTMSFFNFA--MPLFITITSYSLMEQKL 203
Cdd:cd15091   157 DDDYSWWDTFMKICVFIFAfvIPVLIIIVCYTLMILRL 194
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
34-196 2.88e-06

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 46.66  E-value: 2.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15060    18 NILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLpLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 113 RYHHYCTRSQLAWNSAVSLVLF----VWLSSAFWAALPLLGWGHY-DYEPLGTCCTLDYSKGdrnftsFLFTMSFFNFAM 187
Cdd:cd15060    98 RYWAIHDPINYAQKRTLKRVLLmivvVWALSALISVPPLIGWNDWpENFTETTPCTLTEEKG------YVIYSSSGSFFI 171

                  ....*....
gi 1370457564 188 PLFITITSY 196
Cdd:cd15060   172 PLLIMTIVY 180
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
18-196 2.98e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 46.44  E-value: 2.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR-WPYGSDGCQAHGFQGF 96
Cdd:cd15401     2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNgWTLGNIHCQISGFLMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYC--TRSQLAWN--SAVSLVLFVWLSSAFwAALPLLGWGHYDYEPLGTCCTLDYSKGdrn 172
Cdd:cd15401    82 LSVIGSVFNITAIAINRYCYIChsLRYDKLYNmkKTCCYVCLTWVLTLA-AIVPNFFVGSLQYDPRIYSCTFAQTVS--- 157
                         170       180
                  ....*....|....*....|....
gi 1370457564 173 fTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15401   158 -SSYTITVVVVHFIVPLSIVTFCY 180
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
34-176 4.22e-06

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 46.09  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15214    17 NLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLpFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAID 96
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370457564 113 RYHH----YCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKgDRNFTSF 176
Cdd:cd15214    97 RYYAvlypMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMCVAAWHK-EAGYTAF 163
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
18-208 1.11e-05

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 44.78  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLL-VEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd14975     1 VLGCTLLsLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLsSAFWAALPLLGWGHYDYEPLGTCCTL-DYSKGDR 171
Cdd:cd14975    81 VSMYASVFLITLMSLERFlavsRPFVSQGWRAKALAHKVLAIIWL-LAVLLATPVIAFRHVEETVENGMCKYrHYSDGQL 159
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1370457564 172 NFTSFLFTMsfFNFAMPLFITITSYSLMEQKLGKSGH 208
Cdd:cd14975   160 VFHLLLETV--VGFAVPFTAVVLCYSCLLRRLRRRRF 194
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
30-203 1.31e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 44.56  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDG-CQAHGFQGFVTALASICSSAA 108
Cdd:cd14982    14 GLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFlCRLTGLLFYINMYGSILFLTC 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 109 IAWGRY------HHYCTRSQLAWnsAVSLVLFVWLsSAFWAALPLLGWGHYDYEPLG-TCCTLDYSKGDRNFTSFLFTMS 181
Cdd:cd14982    94 ISVDRYlavvhpLKSRRLRRKRY--AVGVCAGVWI-LVLVASVPLLLLRSTIAKENNsTTCFEFLSEWLASAAPIVLIAL 170
                         170       180
                  ....*....|....*....|..
gi 1370457564 182 FFNFAMPLFITITSYSLMEQKL 203
Cdd:cd14982   171 VVGFLIPLLIILVCYSLIIRAL 192
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
19-89 1.40e-05

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 44.52  E-value: 1.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQ 89
Cdd:cd15970     3 ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCR 73
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
22-114 1.71e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 44.42  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISL-NALVAATSSLLRRWPYGSDGCQAHGFQGFVTAL 100
Cdd:cd15202     9 FIIVFSLFG---NVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVH 85
                          90
                  ....*....|....
gi 1370457564 101 ASICSSAAIAWGRY 114
Cdd:cd15202    86 VSAYTLTAIAVDRY 99
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
21-204 1.71e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 44.36  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  21 MVLLveALSGLSLNTLTIFSFCKTPELRT---PCHLLVLSLALADSGISLNALvaATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15220     6 MVLL--DLTALVGNTAVMVVIAKTPHLRKfafVCHLCVVDLLAALLLMPLGIL--SSSPFFLGVVFGEAECRVYIFLSVC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEP--LGTCCTLDYSKGdR 171
Cdd:cd15220    82 LVSASILTISAISVERYyyivHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPApiAARHCSLHWSHS-G 160
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLG 204
Cdd:cd15220   161 HRGVFVVLFALVCFLLPLLLILVVYCGVFKVFG 193
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
18-196 1.94e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 44.27  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADsgISLNALVAATSSLL----RRWPYGSDGCQA-HG 92
Cdd:cd15067     1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVAD--LLVGSIVMPFSILHemtgGYWLFGRDWCDVwHS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQgFVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFwAALPLLGW--GHYDYEPLGTCCTLDY 166
Cdd:cd15067    79 FD-VLASTASILNLCVISLDRYwaitDPISYPSRMTKRRALIMIALVWICSAL-ISFPAIAWwrAVDPGPSPPNQCLFTD 156
                         170       180       190
                  ....*....|....*....|....*....|
gi 1370457564 167 SKGdrnftsFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15067   157 DSG------YLIFSSCVSFYIPLVVMLFTY 180
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
34-139 2.33e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 43.96  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd14992    18 NFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTpFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFD 97
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370457564 113 RY----HHYCTRSQLAWNSAVSLVLFVWLSS 139
Cdd:cd14992    98 RYfaiiHPLKPRHRQSYTTTVIIIITIWVVS 128
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
27-208 2.61e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 43.82  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  27 ALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALAD-SGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICS 105
Cdd:cd15096    11 FIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADlLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 106 SAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWlSSAFWAALPLL---GWGHYDY--EPLGTCC--TLDYSKGDRNFT 174
Cdd:cd15096    91 LVLMSLDRYlavvHPITSMSIRTERNTLIAIVGIW-IVILVANIPVLflhGVVSYGFssEAYSYCTflTEVGTAAQTFFT 169
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370457564 175 SFLftmsFFNFAMPLFITITSYSLMEQKL--GKSGH 208
Cdd:cd15096   170 SFF----LFSYLIPLTLICVLYMLMLRRLrrQKSPG 201
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
17-150 3.36e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 43.25  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15062     1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLpFSATLEVLGYWAFGRIFCDVWAAVD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGW 150
Cdd:cd15062    81 VLCCTASIMSLCVISVDRYigvrYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGW 139
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
18-196 3.96e-05

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 43.30  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR-WPYGSDGCQAHGFQGF 96
Cdd:cd15400     2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNgWALGEMHCKVSGFVMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYHHYC-----TRSQLAWNSAVsLVLFVWLSSAFwAALPLLGWGHYDYEPLGTCCTLDYSKGdr 171
Cdd:cd15400    82 LSVIGSIFNITGIAINRYCYIChsfayDKLYSRWNTLL-YVCLIWALTVV-AIVPNFFVGSLEYDPRIYSCTFVQTAS-- 157
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 nfTSFLFTMSFFNFAMPlfITITSY 196
Cdd:cd15400   158 --SSYTIAVVVIHFIVP--ITVVSF 178
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
22-197 4.17e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 43.19  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGLSL-----NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLL-RRWPYGSDGCQAHGFQG 95
Cdd:cd15050     1 APLGIALSTISLitvilNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLeSKWILGRPVCLFWLSMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYhhYCTRSQLAW------NSAVSLVLFVWLSSAFWaALPLLGWGHYD-----YEPLGTCCTl 164
Cdd:cd15050    81 YVASTASIFSLFILCIDRY--RSVQQPLKYlkyrtkTRASLMISGAWLLSFLW-VIPILGWHHFArggerVVLEDKCET- 156
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370457564 165 DYSKgdrnFTSFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15050   157 DFHD----VTWFKVLTAILNFYIPSLLMLWFYA 185
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
14-166 4.27e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 43.21  E-value: 4.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  14 LEVLAVGMVLLVealsGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR--WPYGSDGCQAH 91
Cdd:cd15005     2 LKLTTLGLILCV----SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGsgWIYGALSCKVI 77
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370457564  92 GFQGFVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDY 166
Cdd:cd15005    78 AFLAVLFCFHSAFTLFCIAVTRYmaiaHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQCTFEH 156
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
34-197 4.57e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 43.10  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADsgISLNALV---AATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIA 110
Cdd:cd15059    18 NVLVIVAVLTSRKLRAPQNWFLVSLAVAD--ILVGLLImpfSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAIS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 111 WGRYhhYCTRSQLAWNSAVS------LVLFVWLSSAFWAALPLLGWGH-YDYEPLGTCCTLDYSKGDRNFTSflfTMSFF 183
Cdd:cd15059    96 LDRY--WSVTQAVEYNLKRTprrakaMIAAVWIISAVISLPPLFGWKDeQPWHGAEPQCELSDDPGYVLFSS---IGSFY 170
                         170
                  ....*....|....
gi 1370457564 184 nfaMPLFITITSYS 197
Cdd:cd15059   171 ---IPLLIMIIVYA 181
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
34-197 5.21e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 42.82  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15058    18 NLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVpLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 113 RYHHyCTR-----SQLAWNSAVSLVLFVWLSSAFWAALPL-LGWGHYDY--------EPlgTCCTLdyskgDRNFTSFLF 178
Cdd:cd15058    98 RYIA-ITRplryqVLLTKRRARVIVCVVWIVSALVSFVPImNQWWRANDpeandcyqDP--TCCDF-----RTNMAYAIA 169
                         170
                  ....*....|....*....
gi 1370457564 179 TmSFFNFAMPLFITITSYS 197
Cdd:cd15058   170 S-SVVSFYIPLLIMIFVYA 187
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
18-193 5.40e-05

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 42.86  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSL-LRRWPYGSDGCQAHGFQGF 96
Cdd:cd15199     2 AYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLnGNRWSLGGGTCKALLFMLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLssafwAALPLLGWGHYDYEPLG-TCCTLDYSKGDR 171
Cdd:cd15199    82 LSRGVSIAFLTAVALDRYfrvvHPRGKKNSLSLQAAPYISFLVWL-----LLVGLTIPTLLASQPKNfTECNSFSPKDDE 156
                         170       180
                  ....*....|....*....|...
gi 1370457564 172 NFTSFLF-TMSFFNFAMPLFITI 193
Cdd:cd15199   157 DFSDTWQeAVFFLQFLLPFGLIV 179
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
34-191 6.44e-05

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 42.61  E-value: 6.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADsgislnALVAA-------TSSLLRRWPYGSDGCQAHGF-QGfVTALASICS 105
Cdd:cd15207    18 NVLVCLVVAKNPRMRTVTNYFILNLAVSD------LLVGVfcmpftlVDNILTGWPFGDVMCKLSPLvQG-VSVAASVFT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 106 SAAIAWGRYHH--YCTRSQLAWNSAVSLVLFVWLSSAF--WAALPLLG---WGHYDYEPLGTCC----TLDYSKGdrnFT 174
Cdd:cd15207    91 LVAIAVDRYRAvvHPTEPKLTNRQAFVIIVAIWVLALAimIPQALVLEvkeYQFFRGQTVHICVefwpSDEYRKA---YT 167
                         170
                  ....*....|....*..
gi 1370457564 175 SFLFTmsfFNFAMPLFI 191
Cdd:cd15207   168 TSLFV---LCYVAPLLI 181
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
19-197 7.43e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 42.42  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTP-CHLLVLSLALADsgISLNALV---AATSSLLRRWPYGSdgcqahgFQ 94
Cdd:cd15057     3 TGCILYLLVLLTLLGNALVIAAVLRFRHLRSKvTNYFIVSLAVSD--LLVAILVmpwAAVNEVAGYWPFGS-------FC 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIA----------WG-----RYHHYCTRSqlawnSAVSLVLFVWLSSAFWAALPL-LGWGHYDYEPL 158
Cdd:cd15057    74 DVWVSFDIMCSTASILnlcvisvdryWAisspfRYERRMTRR-----RAFIMIAVAWTLSALISFIPVqLGWHRADDTSE 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1370457564 159 GTCCTLDYSKGDRNF-TSFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15057   149 ALALYADPCQCDSSLnRTYAISSSLISFYIPVAIMIVTYT 188
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
20-196 8.42e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 42.20  E-value: 8.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  20 GMVLLVEA--LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15958     2 GMSLLMALivLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVpFGATLVVRGRWLYGSFFCELWTSVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGD-R 171
Cdd:cd15958    82 LCVTASIETLCVIAIDRYlaitSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCCDfV 161
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 NFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15958   162 TNRAYAIASSIISFYIPLLIMIFVY 186
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
17-199 8.98e-05

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 42.10  E-value: 8.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRT--PCHLLVLSLALADSGISLNALVAATSSLLR-RWPYGSDGCQAHGF 93
Cdd:cd14976     1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDfVWPFGTAMCKVVRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  94 QGFVTALASICSSAAIAWGRYHHYCTRSQLAWN----SAVSLVLFVWLSSAFwAALPLLGWGHYDYEPLG-TCCTLDYSK 168
Cdd:cd14976    81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIrkafGAFATTIAIWAAAAL-AAIPEAIFSTDTWSSVNhTLCLLRFPK 159
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1370457564 169 GD--RNFTSFL----FTMSFFNFAMPLFITITSYSLM 199
Cdd:cd14976   160 NSsvTRWYNWLgmyqLQKVVLGFFLPLGIITLSYLLL 196
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
18-159 9.57e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.06  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSlNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR--WPYGSDGCQAHGFQG 95
Cdd:cd15212     3 QALVLLAIFLLSSLG-NCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRpgWLFGDRLCLANGFFN 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYC--TRSQLAWNSAVSLVLFVWLSS-AFWAALPLLGWGHYDYEPLG 159
Cdd:cd15212    82 ACFGIVSTLTMTLISFDRYYAIVrqPQGKIGRRRALQLLAAAWLTAlGFSLPWYLLASAPEYYEKLG 148
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
16-196 1.01e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 42.15  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVEAlsglslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAAT-SSLLRRWPYGSDGCQAHGFQ 94
Cdd:cd15318     6 ACAIGMLIIVLG------NLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTiRSVESCWYFGDSFCRLHTCL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  95 GFVTALASICSSAAIAWGRYHHYCT----RSQLAWNSAVSLVLFVWLSSAFWAALPLL------GWGHYDYE-PLGTCCT 163
Cdd:cd15318    80 DTLFCLTSIFHLCFISIDRHCAICDpllyPSKFTIRVACIFIAAGWLVPTVYTSVFLYtkaveeGLAELLTSvPCVGSCQ 159
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 164 LDYSK--GDRNFTSFLFtmsffnfamPLFITITSY 196
Cdd:cd15318   160 LLYNKlwGWLNFPVFFI---------PCLIMIGLY 185
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
28-90 1.19e-04

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 41.77  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQA 90
Cdd:cd15973    12 LVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRT 74
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
19-212 1.39e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 41.75  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVeALSGLSL--NTLTIFSFCKTPELRTPCHLLVLSLALADS-GISLNALVAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15215     1 IRSVLIV-IFLCASLfgNIVLLLVFQRKPQLLQVANRFIFNLLVADLlQTVLVMPWVIATSVPLFWPLDSHLCTALVVLM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSkgdr 171
Cdd:cd15215    80 HLFAFAGVNTIVVVSVDRYlaiiHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCSVIWG---- 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370457564 172 nfTSFLFTM--SFFNFAMPLFITITSYSLMEQKLGKSGHLQAA 212
Cdd:cd15215   156 --SSYSYTIlsVVSSFVLPVIIMLACYSMVFRAARRCYHCKAA 196
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
22-196 1.90e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 41.39  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGLS-----LNTLTIFSFCKTPELRTPCHLLVLSLALADsgiSLNALVAATSSLLRR----WPYGSDGCQAHG 92
Cdd:cd15055     1 VLLYIVLSSISlltvlGNLLVIISISHFKQLHTPTNLLLLSLAVAD---FLVGLLVMPFSMIRSietcWYFGDTFCKLHS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQGFVTALASICSSAAIAWGRYH------HYCTRSQLawNSAVSLVLFVWLSSAFWAALPLLGWGH-YDYEPLGTC---C 162
Cdd:cd15055    78 SLDYILTSASIFNLVLIAIDRYVavcdplLYPTKITI--RRVKICICLCWFVSALYSSVLLYDNLNqPGLIRYNSCygeC 155
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1370457564 163 TLDYSKgdrnftSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15055   156 VVVVNF------IWGVVDLVLTFILPCTVMIVLY 183
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
30-203 1.98e-04

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 41.13  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAI 109
Cdd:cd15090    14 GLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 110 AWGRYHHYCTRSQ-----LAWNSAVSLVLFVWLSSAFwaALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSFLFTMSF-F 183
Cdd:cd15090    94 SVDRYIAVCHPVKaldfrTPRNAKIVNVCNWILSSAI--GLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKICVFiF 171
                         170       180
                  ....*....|....*....|
gi 1370457564 184 NFAMPLFITITSYSLMEQKL 203
Cdd:cd15090   172 AFIMPVLIITVCYGLMILRL 191
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
30-90 2.17e-04

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 40.88  E-value: 2.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQA 90
Cdd:cd15087    14 GLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKL 74
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
30-203 2.26e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 41.12  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADsgiSLNALVAATSSLLRR-----WPYGSDGCQAHGFQGFVTALASIC 104
Cdd:cd14997    14 GVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVAD---LLVLLVCMPVALVETwarepWLLGEFMCKLVPFVELTVAHASVL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 105 SSAAIAWGRYH---------HYCTRSQlawnsAVSLVLFVWLSSAFwAALPLLGWGHY-DYEPLGT----CCTLDYSKGD 170
Cdd:cd14997    91 TILAISFERYYaichplqakYVCTKRR-----ALVIIALIWLLALL-TSSPVLFITEFkEEDFNDGtpvaVCRTPADTFW 164
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1370457564 171 RNFTsFLFTMSFFnFAMPLFITITSYSLMEQKL 203
Cdd:cd14997   165 KVAY-ILSTIVVF-FVVPLAILSGLYSVICRRL 195
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
16-206 2.68e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 40.83  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  16 VLAVGMVLLVeALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLL---RRWPYGSDGCQAHG 92
Cdd:cd14995     1 VVATFLVLLI-CGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLlgpDSWIYGYAGCLLIT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQGFVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVW----LSSAFWAALPLLGWGHYDYEPLGTCctl 164
Cdd:cd14995    80 YLQYLGINASSLSITAFTIERYiaicHPMKAQFICTVSRAKKIICFVWiftsLYCSPWLFLLDLSIKHYGDDIVVRC--- 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1370457564 165 DYsKGDRNFTSFLFTMSFFNF-AMPLFITITSYSLMEQKLGKS 206
Cdd:cd14995   157 GY-KVSRHYYLPIYLADFVLFyVIPLLLAIVLYGLIGRILFSS 198
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
17-196 4.02e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 40.26  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15325     1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLpFSAIFEILGYWAFGRVFCNIWAAVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY--HHYCTR--SQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPlGTCCTLDYSKGDR 171
Cdd:cd15325    81 VLCCTASIMSLCIISIDRYigVSYPLRypSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPED-ETICQITEEPGYA 159
                         170       180
                  ....*....|....*....|....*
gi 1370457564 172 NFTsflftmSFFNFAMPLFITITSY 196
Cdd:cd15325   160 LFS------ALGSFYLPLAIILVMY 178
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-206 4.11e-04

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 40.23  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  47 LRTPCHLLVLSLALADSGIS-LNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTRSQLAW 125
Cdd:cd16002    31 MRTVTNYFLVNLAFAEASMSaFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 126 N-SAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDY--SKGDRNFTSFLFTMSFFNFAMPLFITITSYSLMEQK 202
Cdd:cd16002   111 SaTATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWpeHEERKYETVYHVCVTVLIYFLPLLVIGCAYTVVGIT 190

                  ....
gi 1370457564 203 LGKS 206
Cdd:cd16002   191 LWAS 194
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
30-207 4.93e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 40.15  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  30 GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAI 109
Cdd:cd15094    14 GLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 110 AWGRYHHYC--TRSQLAWNSAVSLV--LFVWLSSaFWAALPLLGWGHYDYEPLGTCCTL-----DYSKGDRNFTSFLFTM 180
Cdd:cd15094    94 SADRYLAVChpIRSMRYRTPFIAKVvcATTWSIS-FLVMLPIILYASTVPDSGRYSCTIvwpdsSAVNGQKAFTLYTFLL 172
                         170       180
                  ....*....|....*....|....*..
gi 1370457564 181 SffnFAMPLFITITSYSLMEQKLGKSG 207
Cdd:cd15094   173 G---FAIPLLLISVFYTLVILRLRTVG 196
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
19-208 5.04e-04

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 39.94  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15927     3 VPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVpFTSTIYTLDSWPFGEFLCKLSEFLKDT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRyhhYCT--------RSQLAWNSAVsLVLFVWLSSAFWAALPLLG-----WGHYDYEPLGTCCTL 164
Cdd:cd15927    83 SIGVSVFTLTALSADR---YFAivnpmrkhRSQATRRTLV-TAASIWIVSILLAIPEAIFshvvtFTLTDNQTIQICYPY 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370457564 165 DYSKGDrNFTSFLFTMSFF-NFAMPLFITITSYSLMEQKLGKSGH 208
Cdd:cd15927   159 PQELGP-NYPKIMVLLRFLvYYLIPLLIIGVFYVLMARHLIRSTR 202
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
22-197 5.24e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 39.92  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  22 VLLVEALSGLSL-----NTLTIFSFCKTPELRTPCHLLVLSLALADsgiSLNALVAATSSLLRR----WPYGSDGCQAHG 92
Cdd:cd15314     1 VLLYIFLGLISLvtvcgNLLVIISIAHFKQLHTPTNYLILSLAVAD---LLVGGLVMPPSMVRSvetcWYFGDLFCKIHS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  93 FQGFVTALASICSSAAIAWGRYHHYCT----RSQLAWNSAVSLVLFVWLSSAFWA-ALPLLGW-GHYDYEPLGTC---CT 163
Cdd:cd15314    78 SFDITLCTASILNLCFISIDRYYAVCQpllyRSKITVRVVLVMILISWSVSALVGfGIIFLELnIKGIYYNHVACeggCL 157
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1370457564 164 LDYSKGdrnftsFLFTMSFFNFAMPLFITITSYS 197
Cdd:cd15314   158 VFFSKV------SSVVGSVFSFYIPAVIMLCIYL 185
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
17-150 5.61e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 39.97  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEalsglslNTLTIFSFCKTPELRTPCHLLVLSLALAD---------SGISLNALVAATSSLLRRWPYGSdg 87
Cdd:cd14972     6 IVLGVFIVVE-------NSLVLAAIIKNRRLHKPMYILIANLAAADllagiafvfTFLSVLLVSLTPSPATWLLRKGS-- 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370457564  88 cqahgfqGFVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGW 150
Cdd:cd14972    77 -------LVLSLLASAYSLLAIAVDRYisivHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGW 136
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
21-196 5.82e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 39.74  E-value: 5.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  21 MVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRR-WPYGSDGCQAHGFQGFVTA 99
Cdd:cd15317     5 IVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETcWYFGDLFCKFHTGLDLLLC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 100 LASICSSAAIAWGRYH------HYCTR--SQLAWnsavSLVLFVWLSSAFWAALpLLGWGHYDYEP---------LGTCC 162
Cdd:cd15317    85 TTSIFHLCFIAIDRYYavcdplRYPSKitVQVAW----RFIAIGWLVPGIYTFG-LIYTGANDEGLeeysseiscVGGCQ 159
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1370457564 163 TLdyskgdrnFTSFLFTMSFFNFAMPLFITITSY 196
Cdd:cd15317   160 LL--------FNKIWVLLDFLTFFIPCLIMIGLY 185
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
22-90 5.96e-04

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 39.75  E-value: 5.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370457564  22 VLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQA 90
Cdd:cd15093     6 IYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRL 74
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
34-137 6.81e-04

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 39.48  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15980    18 NGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMpTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAVD 97
                          90       100
                  ....*....|....*....|....*..
gi 1370457564 113 RYHH--YCTRSQLAWNSAVSLVLFVWL 137
Cdd:cd15980    98 RFRCivYPFKQKLTISTAVVIIVIIWV 124
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
28-205 8.80e-04

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 39.28  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLN-ALVAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSS 106
Cdd:cd14985    12 LVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTlPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 107 AAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSAFwAALP-LLGWGHYDYEPLG-TCCTLDYSKGDRNFTSFLfTM 180
Cdd:cd14985    92 TCMSVDRYlaivHPVASRRLRRRRQARVTCALIWVVACL-LSLPtFLLRSLQAIENLNkTACIMLYPHEAWHFGLSL-EL 169
                         170       180
                  ....*....|....*....|....*
gi 1370457564 181 SFFNFAMPLFITITSYSLMEQKLGK 205
Cdd:cd14985   170 NILGFVLPLLIILTCYFHIARSLRK 194
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
17-205 9.59e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 39.08  E-value: 9.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15957     1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVpFGAAHILLKTWTFGNFWCEFWTSID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYCT----RSQLAWNSAVSLVLFVWLSSAFWAALPL-LGWGHYDyEPLGTCCTLDYSKGD 170
Cdd:cd15957    81 VLCVTASIETLCVIAVDRYFAITSpfkyQSLLTKNKARVIILMVWIVSGLTSFLPIqMHWYRAT-HQEAINCYAEETCCD 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1370457564 171 RNFT-SFLFTMSFFNFAMPLFITITSYSLMEQKLGK 205
Cdd:cd15957   160 FFTNqAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR 195
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
21-114 1.07e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 38.95  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  21 MVLLVEALSGLSLNTLTIFSFCKTPELR-TPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTA 99
Cdd:cd14983     5 MVYVLTILLGLPSNLLALYAFVNRARLRlTPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTL 84
                          90
                  ....*....|....*
gi 1370457564 100 LASICSSAAIAWGRY 114
Cdd:cd14983    85 YASTCFLTAISAGRY 99
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
20-203 1.10e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 38.95  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  20 GMVLLVealsGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNA--LVAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15394     8 SLVVLV----GVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCvpLTLAYAFEPRGWVFGRFMCYFVFLMQPV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRYH--HYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLG-TCCTLDYSKGDRNFT 174
Cdd:cd15394    84 TVYVSVFTLTAIAVDRYYvtVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDfSICEEFWFGQEKQRL 163
                         170       180
                  ....*....|....*....|....*....
gi 1370457564 175 SFLFTMSFFNFAMPLFITITSYSLMEQKL 203
Cdd:cd15394   164 AYACSTLLITYVLPLLAISLSYLRISVKL 192
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
18-205 1.14e-03

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 38.92  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNA-LVAATSSLLRRWPYGSDGCQAHGFQGF 96
Cdd:cd15922     2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAApLLIAYFSLGSHWPFGQFLCQLKVFLLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  97 VTALASICSSAAIAWGRYH---HYCTRSQLAWNSAVS-LVLFVWLsSAFWAALPLLGWGHYDYEPLGTCCtLDYSKGDRN 172
Cdd:cd15922    82 THMYGSIYFLMLISIHRYVtvvHYNWKSLWKKKSFMKkLCLGVWL-LLFVQGLPFFFVLKTSVIDGKTKC-LSIHQSELS 159
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1370457564 173 FTSFLFTM--SFFNFAMPLFITITSYSLMEQKLGK 205
Cdd:cd15922   160 LLYFVWNFvlLILGFLLPFGVSLTCYALLGASIAK 194
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
23-197 1.33e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 38.88  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  23 LLVEALSGLSLNTLTIFSFcktPELRTPCHLLVLSLALADSGISLNALVAATSSLL--RRWPYGSDGCQAHGFQGFVTAL 100
Cdd:cd15392    10 IFVLAVGGNGLVCYIVVSY---PRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLilQYWPFGEFMCPVVNYLQAVSVF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 101 ASICSSAAIAWGRYHHYC--TRSQLAWNSAVSLVLFVWLsSAFWAALPLLGWGHYDYEPLGTC----CTLDYSKG--DRN 172
Cdd:cd15392    87 VSAFTLVAISIDRYVAIMwpLRPRMTKRQALLLIAVIWI-FALATALPIAITSRLFEDSNASCgqyiCTESWPSDtnRYI 165
                         170       180
                  ....*....|....*....|....*
gi 1370457564 173 FTSFLFTMSFFnfaMPLFITITSYS 197
Cdd:cd15392   166 YSLVLMILQYF---VPLAVLVFTYT 187
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
34-185 1.90e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 38.25  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG 112
Cdd:cd15063    18 NLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLpFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 113 RY----HHYCTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGW-----GHYDYEPLGTC---CTLDYSKGDRNFT---SF- 176
Cdd:cd15063    98 RYlaitRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWndgkdGIMDYSGSSSLpctCELTNGRGYVIYSalgSFy 177
                         170
                  ....*....|.
gi 1370457564 177 --LFTMSFFNF 185
Cdd:cd15063   178 ipMLVMLFFYF 188
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
34-193 3.20e-03

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 37.57  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  34 NTLTIFSFCKTPELRTPCHLLVLSLALADsgisLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTAL-ASICSSAAIAWG 112
Cdd:cd15960    18 NAIVIAILFYTPSLRAPMFILIGSLALAD----LLAGLGLIANFVAIYVMNSEAVTLCSAGLLLAAFsASVCSLLAITVD 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 113 RYHH------YCTRSQLAWnsAVSLVLFVWLSSAFWAALPLLGWGHYDYEplGTCCTLDYSKGDRNFTSFLFTMSFFNFA 186
Cdd:cd15960    94 RYLSlynaltYHTERTLTF--TYGLLALLWLTCIGIGLLPAMGWNCLRAP--ASCSVLRPVTKNNAAVLAVSFLLLFALM 169

                  ....*..
gi 1370457564 187 MPLFITI 193
Cdd:cd15960   170 MQLYLQI 176
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
19-203 3.34e-03

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 37.49  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  19 VGMVLLVEALS-GLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFV 97
Cdd:cd15121     2 LGIAILSLAFIlGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  98 TALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSaFWAALPLLGWGH--YDYEPLGTCCTLDYSKGDR 171
Cdd:cd15121    82 SMYASIFLITLMSMDRClavaKPFLSQKMRTKRSVRALLLAIWIVA-FLLSLPMPFYRTvlKKNINMKLCIPYHPSVGHE 160
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370457564 172 NFTSFLFTMSffNFAMPLFITITSYSLMEQKL 203
Cdd:cd15121   161 AFQYLFETIT--GFLLPFTAIVTCYSTIGRRL 190
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
17-203 3.59e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 37.45  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGlslNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15205     4 VITYVLIFVLALFG---NSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIpFTLLQNISSNWLGGAFMCKMVPFVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  96 FVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSSA-----FWAALPLLGWGHYDYEPLGTCCTLDY 166
Cdd:cd15205    81 STAVVTSILTMTCIAVERHqgivHPLKMKWQYTNRRAFTMLGLVWIVSVivgspMLFVQQLEVKYDFLYEKRHVCCLERW 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1370457564 167 S--KGDRNFTSFLFTMSFFnfaMPLFITITSYSLMEQKL 203
Cdd:cd15205   161 YspTQQKIYTTFILVILFL---LPLTTMLFLYSRIGYEL 196
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
17-89 5.09e-03

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 37.09  E-value: 5.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQ 89
Cdd:cd15974     1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCR 73
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
18-114 6.08e-03

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 36.66  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  18 AVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSgISLNALVAATSSLLRR--WPYGSDGCQAHGFQG 95
Cdd:cd14991     2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADF-LLLICLPFRIDYYLRGehWIFGEAWCRVNLFML 80
                          90
                  ....*....|....*....
gi 1370457564  96 FVTALASICSSAAIAWGRY 114
Cdd:cd14991    81 SVNRSASIAFLTAVALDRY 99
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
17-161 6.34e-03

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 36.44  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNAL-VAATSSLLRRWPYGSDGCQAHGFQG 95
Cdd:cd15335     1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMpLSITYIVMDTWTLGYFICEIWLSVD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYC-----TRSQLAWNSAVsLVLFVWLSSAFWAALPLLGWGHYDYEPLGTC 161
Cdd:cd15335    81 MTCCTCSILHLCVIALDRYWAITdaieyARKRTAKRAGL-MILTVWTISIFISIPPLFWRNHHDANIPSQC 150
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
17-153 6.98e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 36.54  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  17 LAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR-RWPYGSDGCQAHGFQG 95
Cdd:cd15300     1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMgYWALGSLACDLWLALD 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370457564  96 FVTALASICSSAAIAWGRYHHYCT----RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHY 153
Cdd:cd15300    81 YVASNASVMNLLVISFDRYFSITRpltyRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYF 142
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
28-205 8.81e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 36.40  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  28 LSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADsgisLNALVAATSSLLRRWPY-----GSDGCQAHGFQGFVTALAS 102
Cdd:cd15131    12 VVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSD----LLIFLCMPLDLYRLWQYrpwnfGDLLCKLFQFVSESCTYST 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 103 ICSSAAIAWGRYHHYC---TRSQLAWNSAVSLVLFVWLSSAFWAALP---LLGWGHYD-YEPLGT--CCTLDYSKGDRNF 173
Cdd:cd15131    88 ILNITALSVERYFAICfplRAKVVVTKRRVKLVILVLWAVSFLSAGPifvLVGVEHENgTNPIDTneCKATEYAVRSGLL 167
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1370457564 174 TSFLFTMSFFnFAMPLFITITSYSLMEQKLGK 205
Cdd:cd15131   168 TIMVWVSSVF-FFLPVFCLTVLYSLIGRKLWR 198
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
23-212 9.06e-03

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 36.32  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564  23 LLVEALSGLSLNTLTIFSF-CKTP-ELRTPCHLLVLSLALADSGISLNALVAATSSLLRRWPYGSDGCQAHGFQGFVTAL 100
Cdd:cd15122     7 LLLAALLGLPGNGFIIWSIlWKMKaRGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457564 101 ASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLsSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSF 176
Cdd:cd15122    87 ASIFIIGLMSLDRClavtRPYLAQSLRKKALVRKILLAIWL-LALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIF 165
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1370457564 177 LFTM-SFFNFAMPLFITITSYSLMEQKLGKSGHLQAA 212
Cdd:cd15122   166 HYTFeTLVAFVLPFGVILFSYSVILVRLKGARFRRRA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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