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Conserved domains on  [gi|1239918754|ref|XP_022278785|]
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vacuolar-sorting protein SNF8 isoform X2 [Canis lupus familiaris]

Protein Classification

EAP30/Vps36 family vacuolar-sorting protein( domain architecture ID 10514443)

EAP30/Vps36 family vacuolar-sorting protein similar to EAP30, a subunit of the ELL complex, and Vps36 involved in Golgi to endosome trafficking

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
6-213 1.12e-64

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


:

Pssm-ID: 427752  Cd Length: 210  Bit Score: 198.99  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754   6 VGAGAIAKKKLAEAKYKERgtvLAEDQLAQMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKG 85
Cdd:pfam04157   1 VGIAALEQRQEQQQEQYEE---LLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754  86 FWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVG 164
Cdd:pfam04157  74 WWMSLLGVGDFYYELAVQIVEVCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1239918754 165 gtYLIqsVPAELNMDHTVVLQ-LAEKNGYVTVSDIKASLKWETERARQVL 213
Cdd:pfam04157 152 --LLV--VQLELNTDQTEVASrLGGLGGYVTASELADNLGWSVARAKEVL 197
 
Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
6-213 1.12e-64

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


Pssm-ID: 427752  Cd Length: 210  Bit Score: 198.99  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754   6 VGAGAIAKKKLAEAKYKERgtvLAEDQLAQMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKG 85
Cdd:pfam04157   1 VGIAALEQRQEQQQEQYEE---LLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754  86 FWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVG 164
Cdd:pfam04157  74 WWMSLLGVGDFYYELAVQIVEVCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1239918754 165 gtYLIqsVPAELNMDHTVVLQ-LAEKNGYVTVSDIKASLKWETERARQVL 213
Cdd:pfam04157 152 --LLV--VQLELNTDQTEVASrLGGLGGYVTASELADNLGWSVARAKEVL 197
 
Name Accession Description Interval E-value
EAP30 pfam04157
EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved ...
6-213 1.12e-64

EAP30/Vps36 family; This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.


Pssm-ID: 427752  Cd Length: 210  Bit Score: 198.99  E-value: 1.12e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754   6 VGAGAIAKKKLAEAKYKERgtvLAEDQLAQMSKQLDMFKTnLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLasgKG 85
Cdd:pfam04157   1 VGIAALEQRQEQQQEQYEE---LLSSAFEDLEALMEKFKE-LVEFAEKHKKKIKKNPEFRAQFQSMCASLGVDPL---TF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239918754  86 FWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGkfAQDVSQDDLIRAIKKL-KALGTGFGIIPVG 164
Cdd:pfam04157  74 WWMSLLGVGDFYYELAVQIVEVCLATRDENGGLISLDDLYARVNRARG--VELISPDDLLRAIKLLeLVLGSRLRKFKSG 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1239918754 165 gtYLIqsVPAELNMDHTVVLQ-LAEKNGYVTVSDIKASLKWETERARQVL 213
Cdd:pfam04157 152 --LLV--VQLELNTDQTEVASrLGGLGGYVTASELADNLGWSVARAKEVL 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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