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Conserved domains on  [gi|1188092901|ref|XP_020792841|]
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magnesium transporter MRS2 homolog, mitochondrial [Boleophthalmus pectinirostris]

Protein Classification

CorA family magnesium transporter( domain architecture ID 10191269)

CorA family magnesium transporter, belonging to the CorA metal ion transporter (MIT) family, mediates the influx of magnesium ions, similar to mitochondrial inner membrane magnesium transporter MRS2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 98-405 3.84e-110

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213357  Cd Length: 323  Bit Score: 326.89  E-value: 3.84e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901  98 VMRFDQEGNVTTFEKKKTELCQELSLQARDLRFQHST------SLTARNNCIIIRMESLKAIVTLESLQVLDFRGVGLE- 170
Cdd:cd12823     1 WTVIDSTGNATVVELDKSELLRELGLQPRDLRLLDPTltsyppSILVRENAILVNLEHIRAIITADEVLLFDPDGSSSAl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 171 -RWLVLELAPQLATQT---------YSLPFEFRALEAILQHRVNTLQTRLNEVEPVILDTLESLVDPKilsaDRSKLHVL 240
Cdd:cd12823    81 vSAFLEELQRRLASSNgsesesggeDSLPFEFRALEAALEEVCSHLEAELKRLEPEALPLLDELTDKI----STSNLERL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 241 LQNSKSLSELETDIKVFKESLLKILDEDEMIEELCLTKWTDPRVFEESSLGIDHAEEMELLLENYYMQAEELGNKARELK 320
Cdd:cd12823   157 LPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEEVEMLLEAYLQQVDELLNKLEELR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 321 GLIDDSESVIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLIGVAFGMNLESSFEEDPRVFWLVTGFMFLGSGLIWRRLLS 400
Cdd:cd12823   237 EYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESPYAFWIVTGGSVVGSILIFIVVLR 316


                  ....*
gi 1188092901 401 FLGRH 405
Cdd:cd12823   317 YLRRK 321
 
Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 98-405 3.84e-110

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 326.89  E-value: 3.84e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901  98 VMRFDQEGNVTTFEKKKTELCQELSLQARDLRFQHST------SLTARNNCIIIRMESLKAIVTLESLQVLDFRGVGLE- 170
Cdd:cd12823     1 WTVIDSTGNATVVELDKSELLRELGLQPRDLRLLDPTltsyppSILVRENAILVNLEHIRAIITADEVLLFDPDGSSSAl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 171 -RWLVLELAPQLATQT---------YSLPFEFRALEAILQHRVNTLQTRLNEVEPVILDTLESLVDPKilsaDRSKLHVL 240
Cdd:cd12823    81 vSAFLEELQRRLASSNgsesesggeDSLPFEFRALEAALEEVCSHLEAELKRLEPEALPLLDELTDKI----STSNLERL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 241 LQNSKSLSELETDIKVFKESLLKILDEDEMIEELCLTKWTDPRVFEESSLGIDHAEEMELLLENYYMQAEELGNKARELK 320
Cdd:cd12823   157 LPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEEVEMLLEAYLQQVDELLNKLEELR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 321 GLIDDSESVIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLIGVAFGMNLESSFEEDPRVFWLVTGFMFLGSGLIWRRLLS 400
Cdd:cd12823   237 EYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESPYAFWIVTGGSVVGSILIFIVVLR 316


                  ....*
gi 1188092901 401 FLGRH 405
Cdd:cd12823   317 YLRRK 321
 
Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 98-405 3.84e-110

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 326.89  E-value: 3.84e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901  98 VMRFDQEGNVTTFEKKKTELCQELSLQARDLRFQHST------SLTARNNCIIIRMESLKAIVTLESLQVLDFRGVGLE- 170
Cdd:cd12823     1 WTVIDSTGNATVVELDKSELLRELGLQPRDLRLLDPTltsyppSILVRENAILVNLEHIRAIITADEVLLFDPDGSSSAl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 171 -RWLVLELAPQLATQT---------YSLPFEFRALEAILQHRVNTLQTRLNEVEPVILDTLESLVDPKilsaDRSKLHVL 240
Cdd:cd12823    81 vSAFLEELQRRLASSNgsesesggeDSLPFEFRALEAALEEVCSHLEAELKRLEPEALPLLDELTDKI----STSNLERL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 241 LQNSKSLSELETDIKVFKESLLKILDEDEMIEELCLTKWTDPRVFEESSLGIDHAEEMELLLENYYMQAEELGNKARELK 320
Cdd:cd12823   157 LPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEEVEMLLEAYLQQVDELLNKLEELR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 321 GLIDDSESVIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLIGVAFGMNLESSFEEDPRVFWLVTGFMFLGSGLIWRRLLS 400
Cdd:cd12823   237 EYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESPYAFWIVTGGSVVGSILIFIVVLR 316


                  ....*
gi 1188092901 401 FLGRH 405
Cdd:cd12823   317 YLRRK 321
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 285-395 9.57e-04

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 40.95  E-value: 9.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1188092901 285 FEESSLGIDHAEEMELL----LENYymQAEELGNKARE-LKGLIDDSESVIFINLdshrNVMMRLnlqLTMGTFSLSLFG 359
Cdd:cd12827   174 LKRSRSLKLDEEDKELLedviIENK--QAIEMAEIYSDiLSGLMDAFASVISNNL----NNVMKF---LTSITIVLTIPT 244

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1188092901 360 LIGVAFGMNLESSFEEDPRVFWLVTGFMFLGSGLIW 395
Cdd:cd12827   245 IITGFYGMNVPLPFADSPYAFWIILLISLLLSVIVA 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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