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Conserved domains on  [gi|1034609391|ref|XP_016882760|]
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zinc finger protein 227 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609391 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609391 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 8.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034609391 343 NLRVHQRVHRGEKPYKCEECGKGFTQ 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-728 6.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 6.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 355 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 432
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 433 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 489
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 490 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 563
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 564 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 636
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 637 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 705
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|...
gi 1034609391 706 ARLEAHQRVHTGEKPYKCDICDK 728
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-655 2.64e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 224 EKCFSQSSHLRTHQRIHPGEKLNRCHESGD---CFNKSSFHSYQSNHTGEKSYRC-DSCGKGFSSSTGLIIHYRTHTGEK 299
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSND 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 300 PYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECgkgFGWSVNLRVHQRVHrgeKPYKCEECGKGFTQAAHFHIHQRVH 379
Cdd:COG5048   120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 380 TGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVH 459
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 460 QNVHTGekrfkcetcgkgfSQSSKLQThqrvhtgeKPYRCDVCGKDFSYSSNLKLHQ--VIHTGE--KPYKCEE--CGKG 533
Cdd:COG5048   274 SPNESD-------------SSSEKGFS--------LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 534 FSWRSNLHAHQRVHSGEKPYKC--EQCDKSFSQAIDFRVHQRV--HTGEKPYKCGV-----CGKGFSQSSGLQSHQRVHT 604
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHL 412

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034609391 605 GEKP--YKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKgFGRSLNLRHH 655
Cdd:COG5048   413 SFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 549-632 2.52e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 549 GEKPYKCE--QCDKSFSQAIDFRVHqRVHtgekpykcGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIY 626
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1034609391 627 HqRGHT 632
Cdd:COG5189   417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
469-747 2.67e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 469 FKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL--HQVIHTGEKPYKCEECGKG--FSWRSNLHAHQ 544
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 545 RVHS--GEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQ-------------------SHQRVH 603
Cdd:COG5048   114 SSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 604 TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECG------KAFSLP 677
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034609391 678 SNLRVHLGVHTREKL-FKCEECGKGFSQSARLEAHQR--VHTGE--KPYKCDI--CDKDFRHRSRLTYHQKVHTGKK 747
Cdd:COG5048   274 SPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-368 8.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034609391 343 NLRVHQRVHRGEKPYKCEECGKGFTQ 368
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
596-620 9.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.06e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609391 596 LQSHQRVHTGEKPYKCDVCGKGFRY 620
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-508 9.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.15e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609391 484 LQTHQRVHTGEKPYRCDVCGKDFSY 508
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 437-515 1.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 437 GEKPYKCK--ECGKGFSQASNLQVHQnvhtgekrfKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL 514
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1034609391 515 H 515
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 566-660 1.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 566 IDFRVHQRVHTGEKPYKCGV--CGKGFSQSSGLQSHqRVHTGEKPYKCDVCGKgfryssqfIYHQRGHTGEKPYKCEECG 643
Cdd:COG5189   335 IDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCD 405

                          90
                  ....*....|....*..
gi 1034609391 644 KGFGRSLNLRHHqRVHT 660
Cdd:COG5189   406 KRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 521-604 1.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 521 GEKPYKCE--ECGKGFSWRSNLHAHqRVHSGEKPYKCEQCDKSfsqaidfrVHQRVHTGEKPYKCGVCGKGFSQSSGLQS 598
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1034609391 599 HqRVHT 604
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
707-732 2.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609391 707 RLEAHQRVHTGEKPYKCDICDKDFRH 732
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 3.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1034609391 511 NLKLHQVIHTGEKPYKCEECGKGFS 535
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 291 HYRTHTGEKPYKCEECGKCFSQ 312
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-741 3.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 661 GEKPHICE--ECGKAFSLPSNLRVHLgvhtreklfKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTY 738
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1034609391 739 HQK 741
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-564 5.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.05e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 543 HQRVHSGEKPYKCEQCDKSFSQ 564
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-452 6.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 431 HFRVHTGEKPYKCKECGKGFSQ 452
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-396 6.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.40e-03
                          10        20
                  ....*....|....*....|..
gi 1034609391 375 HQRVHTGEKPYKCDVCGKGFSH 396
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 353-404 6.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034609391 353 GEKPYKCE--ECGKGFTQA-------AHFHIHQRVH------------TGEKPYKCDVCGKGFSHNSPLICHR 404
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQnglkyhmLHGHQNQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 605-685 7.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609391 605 GEKPYKCDVCGKGFRYSSQF--IYHQR-GHTGEKPYKCEECGKgfgrslnlrhHQRVHTGEKPHICEECGKAFSLPSNLR 681
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNglKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....
gi 1034609391 682 VHLG 685
Cdd:COG5189   416 YHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 9.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.14e-03
                          10        20
                  ....*....|....*....|...
gi 1034609391 441 YKCKECGKGFSQASNLQVHQNVH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
567-592 9.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609391 567 DFRVHQRVHTGEKPYKCGVCGKGFSQ 592
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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