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Conserved domains on  [gi|1034603451|ref|XP_016881048|]
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cerebellin-2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
C1q super family cl23878
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
86-224 3.06e-48

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


The actual alignment was detected with superfamily member smart00110:

Pssm-ID: 420072  Cd Length: 135  Bit Score: 154.77  E-value: 3.06e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451   86 VRSGSAKVAFSATRsTNHEPSEMsnrtMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNrqTIQVSLMQN 165
Cdd:smart00110   1 NYKAQPRSAFSVIR-SNRPPPPG----QPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGR--NVKVSLMKN 73
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034603451  166 GYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLER---GNLMGGWKYSTFSGFLVFPL 224
Cdd:smart00110  74 GIQVMSTYDEYQKGLYDVASGGALLQLRQGDQVWLELPDeknGLYAGEYVDSTFSGFLLFPD 135
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
86-224 3.06e-48

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 154.77  E-value: 3.06e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451   86 VRSGSAKVAFSATRsTNHEPSEMsnrtMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNrqTIQVSLMQN 165
Cdd:smart00110   1 NYKAQPRSAFSVIR-SNRPPPPG----QPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGR--NVKVSLMKN 73
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034603451  166 GYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLER---GNLMGGWKYSTFSGFLVFPL 224
Cdd:smart00110  74 GIQVMSTYDEYQKGLYDVASGGALLQLRQGDQVWLELPDeknGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
94-221 3.85e-36

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310  Cd Length: 126  Bit Score: 123.55  E-value: 3.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451  94 AFSATRSTNHEPSEmsnrTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYnRQTIQVSLMQNGYPVISAF 173
Cdd:pfam00386   1 AFSAGRTTGLTAPN----EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFY 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034603451 174 AGDQDVTREAASNGVLLLMEREDKVHLKLERGNLM---GGWKYSTFSGFLV 221
Cdd:pfam00386  76 DQPQKGSLDVASGSVVLELQRGDEVWLQLTGYNGLyydGSDTDSTFSGFLL 126
COG5476 COG5476
Microcystin degradation protein MlrC, contains DUF1485 domain [General function prediction ...
50-143 3.54e-03

Microcystin degradation protein MlrC, contains DUF1485 domain [General function prediction only];


Pssm-ID: 227763 [Multi-domain]  Cd Length: 488  Bit Score: 37.74  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451  50 RAQNDTEPIVLEGKCLVVCDSSPSADGAVTSSLGIS--VRSGSAKVAFSATRSTNHEPSEMSN-----RTMTIyfdqVLV 122
Cdd:COG5476   358 KSGPQSEPVDVEVKVERLADGGFQSFGPVRVDLGPTavVRIGGIDVILNTNRTQTFDPDIFSLlgidpGTKRV----LVV 433
                          90       100
                  ....*....|....*....|....*.
gi 1034603451 123 NIGNHF-----DLASSIFVAPRKGIY 143
Cdd:COG5476   434 KSTNHFragfaPIAEEILYVEAPGPY 459
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
86-224 3.06e-48

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 154.77  E-value: 3.06e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451   86 VRSGSAKVAFSATRsTNHEPSEMsnrtMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNrqTIQVSLMQN 165
Cdd:smart00110   1 NYKAQPRSAFSVIR-SNRPPPPG----QPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGR--NVKVSLMKN 73
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034603451  166 GYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLER---GNLMGGWKYSTFSGFLVFPL 224
Cdd:smart00110  74 GIQVMSTYDEYQKGLYDVASGGALLQLRQGDQVWLELPDeknGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
94-221 3.85e-36

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310  Cd Length: 126  Bit Score: 123.55  E-value: 3.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451  94 AFSATRSTNHEPSEmsnrTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYnRQTIQVSLMQNGYPVISAF 173
Cdd:pfam00386   1 AFSAGRTTGLTAPN----EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFY 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034603451 174 AGDQDVTREAASNGVLLLMEREDKVHLKLERGNLM---GGWKYSTFSGFLV 221
Cdd:pfam00386  76 DQPQKGSLDVASGSVVLELQRGDEVWLQLTGYNGLyydGSDTDSTFSGFLL 126
COG5476 COG5476
Microcystin degradation protein MlrC, contains DUF1485 domain [General function prediction ...
50-143 3.54e-03

Microcystin degradation protein MlrC, contains DUF1485 domain [General function prediction only];


Pssm-ID: 227763 [Multi-domain]  Cd Length: 488  Bit Score: 37.74  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603451  50 RAQNDTEPIVLEGKCLVVCDSSPSADGAVTSSLGIS--VRSGSAKVAFSATRSTNHEPSEMSN-----RTMTIyfdqVLV 122
Cdd:COG5476   358 KSGPQSEPVDVEVKVERLADGGFQSFGPVRVDLGPTavVRIGGIDVILNTNRTQTFDPDIFSLlgidpGTKRV----LVV 433
                          90       100
                  ....*....|....*....|....*.
gi 1034603451 123 NIGNHF-----DLASSIFVAPRKGIY 143
Cdd:COG5476   434 KSTNHFragfaPIAEEILYVEAPGPY 459
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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