NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034651512|ref|XP_016866741|]
View 

zinc finger protein 76 isoform X7 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-378 2.29e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 191 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 265
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 266 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 339
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034651512 340 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 378
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-378 2.29e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 191 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 265
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 266 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 339
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034651512 340 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 378
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-250 4.08e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.08e-06
                          10        20
                  ....*....|....*....|....*..
gi 1034651512 224 LKSHVRTHTGEKPYKCPEelCSKAFKT 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 326-375 4.35e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 4.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034651512 326 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 375
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-378 2.29e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 191 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--KPYKCPEELCSKAFKTSGDLQKHVRTHTGER 265
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 266 PFQCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT- 339
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNr 430

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1034651512 340 EYSSlyKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRS 378
Cdd:COG5048   431 HYNL--IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-348 1.04e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 182 KGCGRLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTS 251
Cdd:COG5048   293 KQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPP 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 252 GDLQKHVRTHTgERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCtv 331
Cdd:COG5048   373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         170
                  ....*....|....*..
gi 1034651512 332 pgCGKRFTEYSSLYKHH 348
Cdd:COG5048   450 --SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-380 1.83e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 235 KPYKCPEelCSKAFKTSGDLQKHVRT--HTGE--RPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTS 310
Cdd:COG5048   288 LPIKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034651512 311 ATNYKNHVRIH-----TGEKPYVCTVPGCGKRFTEYSSLYKHHVVH----THCkpYTCSTCGKTYRQTSTLAMHKRSAH 380
Cdd:COG5048   366 LLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfrPYN--CKNPPCSKSFNRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-353 8.21e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 57.81  E-value: 8.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 263 GERPFQCPFEGCGRSFTTSNIRKVH-VRTHTGERPYTCPEPHCGRGFTSAtnyknhvrihtgEKPYVCTVpgCGKRFTEY 341
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|..
gi 1034651512 342 SSLyKHHVVHTH 353
Cdd:COG5189   412 NGL-KYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 323-380 1.42e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 57.04  E-value: 1.42e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034651512 323 GEKPYVCTVPGCGKRFTEYSSLyKHHVVHTHC--------------------KPYTCSTCGKTYRQTSTLAMHKRSAH 380
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-352 1.25e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034651512 295 RPYTCPEphCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHT 352
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-250 4.08e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.08e-06
                          10        20
                  ....*....|....*....|....*..
gi 1034651512 224 LKSHVRTHTGEKPYKCPEelCSKAFKT 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
204-262 4.60e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034651512 204 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHT 262
Cdd:COG5048    31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 203-292 1.01e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 203 GDRPYRCDFPSCGKAFATGYGLKSH-VRTHTGEKPYKCPEELCSKAFKTSgdlqkhvrthtgERPFQCPFegCGRSFTTS 281
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|.
gi 1034651512 282 NIRKVHvRTHT 292
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-280 3.66e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.66e-05
                          10        20
                  ....*....|....*....|....*...
gi 1034651512 253 DLQKHVRTHTGERPFQCPFegCGRSFTT 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 152-232 3.72e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 152 RLFPQVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGRLYTTAHHLKVH---------------ERAHTG----DRPYRC 209
Cdd:COG5189   322 SSNGKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRC 401

                          90       100
                  ....*....|....*....|...
gi 1034651512 210 DFpsCGKAFATGYGLKSHvRTHT 232
Cdd:COG5189   402 EV--CDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-387 1.36e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 235 KPYKCPEelCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCpephcgrgftSATNY 314
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN----------SKSLP 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034651512 315 KNHVrihtgeKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATE 387
Cdd:COG5048   100 LSNS------KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS 166
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-287 1.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 127 WRTWQQRMMRASVQTQWWpwssmpaRLFPQVLHDSQiprngkgqqvGDRAFRCGYKGCGRLYTTAHHLKVHERAHTG--- 203
Cdd:COG5048   289 PIKSKQCNISFSRSSPLT-------RHLRSVNHSGE----------SLKPFSCPYSLCGKLFSRNDALKRHILLHTSisp 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651512 204 --------------------------------DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTS 251
Cdd:COG5048   352 akekllnssskfspllnneppqslqqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1034651512 252 GDLQKHVRTHTGERPFQCpfEGCGRSFTTSNIRKVH 287
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-339 3.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|....*..
gi 1034651512 313 NYKNHVRIHTGEKPYVCTVpgCGKRFT 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-220 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034651512 193 HLKVHERAHTGDRPYRCdfPSCGKAFAT 220
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034651512 285 KVHVRTHTGERPYTCPEphCGRGFTS 310
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 326-375 4.35e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 4.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034651512 326 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 375
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH