|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed). :
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 610.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 37 SCTECVRVDKDCAYCTDELFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTKTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2468543976 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
5.47e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions. :
Pssm-ID: 462325 Cd Length: 84 Bit Score: 105.82 E-value: 5.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2468543976 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.39e-25 |
|
Calx-beta domain; :
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2468543976 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1572-1657 |
4.66e-22 |
|
Fibronectin type III domain; :
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 91.71 E-value: 4.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATTFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2468543976 1652 EGFGPE 1657
Cdd:pfam00041 79 GGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1458-1539 |
1.57e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. :
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.86 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1458 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 2468543976 1537 GWG 1539
Cdd:cd00063 81 GES 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
5.99e-16 |
|
Fibronectin type III domain; :
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 5.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2468543976 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1220-1313 |
3.15e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases. :
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 2468543976 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
8.27e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end. :
Pssm-ID: 465729 Cd Length: 29 Bit Score: 55.19 E-value: 8.27e-10
10 20
....*....|....*....|....*....
gi 2468543976 457 CELQKEVRSARCSFNGDFMCGHCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.44e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. :
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.44e-03
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 610.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 37 SCTECVRVDKDCAYCTDELFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTKTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2468543976 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
125-370 |
9.24e-150 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 9.24e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 2468543976 361 EAFNRIRSNL 370
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
5.47e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 105.82 E-value: 5.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2468543976 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.39e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2468543976 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
991-1084 |
2.71e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 2468543976 1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1572-1657 |
4.66e-22 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 91.71 E-value: 4.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATTFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2468543976 1652 EGFGPE 1657
Cdd:pfam00041 79 GGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1458-1539 |
1.57e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.86 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1458 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 2468543976 1537 GWG 1539
Cdd:cd00063 81 GES 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1459-1541 |
1.82e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1459 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 2468543976 1537 GWGRE 1541
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1571-1656 |
6.69e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 77.54 E-value: 6.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAqGGGPATTFRVDgDSPESRLTVPGLSENVPYKFKVQART 1650
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 2468543976 1651 TEGFGP 1656
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
5.99e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 5.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2468543976 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1458-1539 |
1.47e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 73.42 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1458 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1535
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 2468543976 1536 EGWG 1539
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1571-1655 |
4.68e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 71.88 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATTFRVDGDSPESRLTVPGLSENVPYKFKVQART 1650
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 2468543976 1651 TEGFG 1655
Cdd:smart00060 79 GAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1444-1676 |
1.66e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 78.89 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1444 TSVSSHDFRLTAGV--PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLL 1521
Cdd:COG3401 217 ESAPSNEVSVTTPTtpPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLT 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1522 PNHSYVFRVRAQSQEGwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGD 1600
Cdd:COG3401 294 NGTTYYYRVTAVDAAG----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDAD 354
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2468543976 1601 IVGYLVTcemaQGGGPATTFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1676
Cdd:COG3401 355 VTGYNVY----RSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1220-1313 |
3.15e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 2468543976 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1221-1309 |
3.19e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 2468543976 1301 RNGAGWGPE 1309
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1128-1215 |
2.32e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.52 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2468543976 1204 EGPYSSLVSCRT 1215
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
992-1106 |
5.55e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2468543976 1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
8.27e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 55.19 E-value: 8.27e-10
10 20
....*....|....*....|....*....
gi 2468543976 457 CELQKEVRSARCSFNGDFMCGHCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1128-1205 |
1.54e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2468543976 1204 EG 1205
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1220-1307 |
1.81e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 2468543976 1300 ARNGAGWG 1307
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1509-1653 |
1.59e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 59.63 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1509 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1587
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2468543976 1588 QLSWERPrrPNGDIVGYLVtcemAQGGGPATTFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1653
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1146-1305 |
2.00e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.44e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.44e-03
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1111-1268 |
2.66e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 42.68 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1111 SFTSQMLSSQPPPhgdlGAPQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1189
Cdd:COG3401 315 SNVVSVTTDLTPP----AAPSGLTATAVGSSSITLSWTASSDADvTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPG 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1190 CDYEMKVCAYGAQG-EGPYSSLVSCRT----HQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDN 1264
Cdd:COG3401 391 TTYYYKVTAVDAAGnESAPSEEVSATTasaaSGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470
|
....
gi 2468543976 1265 RPIG 1268
Cdd:COG3401 471 TTTS 474
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
37-453 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 610.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 37 SCTECVRVDKDCAYCTDELFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 110
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 111 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 190
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 191 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 266
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 267 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 346
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 347 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTKTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 426
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2468543976 427 PEDQKGNIHLKP-SFSDGLKMDAGIICD 453
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
125-370 |
9.24e-150 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 9.24e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 125 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 200
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 201 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 280
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 281 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 360
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 2468543976 361 EAFNRIRSNL 370
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
626-709 |
5.47e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 105.82 E-value: 5.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 626 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 703
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2468543976 704 KDCPPG 709
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
990-1084 |
3.39e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 990 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1068
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2468543976 1069 SLLRGRqvRRFHVQLS 1084
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
991-1084 |
2.71e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 991 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1070
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 2468543976 1071 LRGrqVRRFHVQLS 1084
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1572-1657 |
4.66e-22 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 91.71 E-value: 4.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1572 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATTFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1651
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2468543976 1652 EGFGPE 1657
Cdd:pfam00041 79 GGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1458-1539 |
1.57e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.86 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1458 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 2468543976 1537 GWG 1539
Cdd:cd00063 81 GES 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1459-1541 |
1.82e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1459 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1536
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 2468543976 1537 GWGRE 1541
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1571-1656 |
6.69e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 77.54 E-value: 6.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAqGGGPATTFRVDgDSPESRLTVPGLSENVPYKFKVQART 1650
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREK-GSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 2468543976 1651 TEGFGP 1656
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1128-1208 |
5.99e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 5.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2468543976 1204 EGPYS 1208
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1458-1539 |
1.47e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 73.42 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1458 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1535
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 2468543976 1536 EGWG 1539
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1571-1655 |
4.68e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 71.88 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1571 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATTFRVDGDSPESRLTVPGLSENVPYKFKVQART 1650
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 2468543976 1651 TEGFG 1655
Cdd:smart00060 79 GAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1444-1676 |
1.66e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 78.89 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1444 TSVSSHDFRLTAGV--PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLL 1521
Cdd:COG3401 217 ESAPSNEVSVTTPTtpPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLT 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1522 PNHSYVFRVRAQSQEGwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGD 1600
Cdd:COG3401 294 NGTTYYYRVTAVDAAG----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDAD 354
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2468543976 1601 IVGYLVTcemaQGGGPATTFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1676
Cdd:COG3401 355 VTGYNVY----RSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1220-1313 |
3.15e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.83 E-value: 3.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 2468543976 1300 ARNGAGWGPEREAI 1313
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1221-1309 |
3.19e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1221 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1300
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 2468543976 1301 RNGAGWGPE 1309
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1128-1215 |
2.32e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.52 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2468543976 1204 EGPYSSLVSCRT 1215
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| PSI_integrin |
pfam17205 |
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ... |
28-73 |
1.55e-10 |
|
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.
Pssm-ID: 465380 Cd Length: 47 Bit Score: 57.94 E-value: 1.55e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2468543976 28 NRCKKApVKSCTECVRVDKDCAYCTDELF--RDRRCNTQAELLAAGCQ 73
Cdd:pfam17205 1 NRCTSA-STSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1129-1305 |
1.84e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 65.79 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1129 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1199
Cdd:COG3401 235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1200 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1278
Cdd:COG3401 306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377
|
170 180
....*....|....*....|....*..
gi 2468543976 1279 KNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
992-1106 |
5.55e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1068
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2468543976 1069 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1106
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
457-485 |
8.27e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 55.19 E-value: 8.27e-10
10 20
....*....|....*....|....*....
gi 2468543976 457 CELQKEVRSARCSFNGDFMCGHCVCSEGW 485
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1128-1205 |
1.54e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1128 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1203
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2468543976 1204 EG 1205
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1220-1307 |
1.81e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 56.08 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1220 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1299
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 2468543976 1300 ARNGAGWG 1307
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1509-1653 |
1.59e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 59.63 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1509 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1587
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2468543976 1588 QLSWERPrrPNGDIVGYLVtcemAQGGGPATTFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1653
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1146-1305 |
2.00e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1146 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1225
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1226 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1305
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
978-1087 |
2.05e-06 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 52.87 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKE 1056
Cdd:TIGR00845 516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595
|
90 100 110
....*....|....*....|....*....|.
gi 2468543976 1057 LQVKLLELQEVDsllrgRQVrRFHVQLSNPK 1087
Cdd:TIGR00845 596 IRVKIVDDEEYE-----KND-TFFIELGEPR 620
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
550-573 |
1.44e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 37.71 E-value: 1.44e-03
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1111-1268 |
2.66e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 42.68 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1111 SFTSQMLSSQPPPhgdlGAPQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1189
Cdd:COG3401 315 SNVVSVTTDLTPP----AAPSGLTATAVGSSSITLSWTASSDADvTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPG 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468543976 1190 CDYEMKVCAYGAQG-EGPYSSLVSCRT----HQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDN 1264
Cdd:COG3401 391 TTYYYKVTAVDAAGnESAPSEEVSATTasaaSGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470
|
....
gi 2468543976 1265 RPIG 1268
Cdd:COG3401 471 TTTS 474
|
|
|