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Conserved domains on  [gi|982942573|ref|XP_015329525|]
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WW domain-containing adapter protein with coiled-coil isoform X4 [Bos taurus]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943
SCOP:  3001621

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 88-115 3.14e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 3.14e-09
                          10        20
                  ....*....|....*....|....*...
gi 982942573   88 DDWSEHISSSGKKYYYNCRTEVSQWEKP 115
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 190-512 9.42e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 9.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  190 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGastlsklPTPTSSVPAQRTERKESTSGDKA 269
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDD-------PAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  270 VSHSCTTPSTSSASGLNPTSA----PPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVL 345
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  346 TAAVTQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPI 420
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  421 KPLISTPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVspRSLQRSNSQRSPSPGPnhtsssnasntavVPQ 499
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPV--RRLARPAVSRSTESFA-------------LPP 2902

                         330
                  ....*....|...
gi 982942573  500 NSSARPPCSLTPT 512
Cdd:PHA03247 2903 DQPERPPQPQAPP 2915
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
86-153 2.54e-03

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.83  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  86 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 151
Cdd:COG5104   54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                 ..
gi 982942573 152 TS 153
Cdd:COG5104  134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 88-115 3.14e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 3.14e-09
                          10        20
                  ....*....|....*....|....*...
gi 982942573   88 DDWSEHISSSGKKYYYNCRTEVSQWEKP 115
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 88-117 1.10e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.99  E-value: 1.10e-08
                         10        20        30
                 ....*....|....*....|....*....|
gi 982942573  88 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 117
Cdd:cd00201    2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-512 9.42e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 9.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  190 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGastlsklPTPTSSVPAQRTERKESTSGDKA 269
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDD-------PAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  270 VSHSCTTPSTSSASGLNPTSA----PPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVL 345
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  346 TAAVTQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPI 420
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  421 KPLISTPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVspRSLQRSNSQRSPSPGPnhtsssnasntavVPQ 499
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPV--RRLARPAVSRSTESFA-------------LPP 2902

                         330
                  ....*....|...
gi 982942573  500 NSSARPPCSLTPT 512
Cdd:PHA03247 2903 DQPERPPQPQAPP 2915
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 90-117 1.11e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.11e-06
                           10        20
                   ....*....|....*....|....*...
gi 982942573    90 WSEHISSSGKKYYYNCRTEVSQWEKPKE 117
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PRP40 COG5104
Splicing factor [RNA processing and modification];
87-123 6.48e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.76  E-value: 6.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 982942573  87 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 123
Cdd:COG5104   14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
86-153 2.54e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.83  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  86 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 151
Cdd:COG5104   54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                 ..
gi 982942573 152 TS 153
Cdd:COG5104  134 TS 135
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 189-495 5.60e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  189 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTL----QSDHQPKKSFDANGASTLSKLPTP--TSSVPAQRTERKE 262
Cdd:pfam05109 454 VPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPspspRDNGTESKAPDMTSPTSAVTTPTPnaTSPTPAVTTPTPN 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  263 STS---GDKAVSHSCTTPSTssasglNPTSAPPASAsaipvSPVPQSPIPPLLQDPNLLRQLLPALQATL-QLNNSNVDI 338
Cdd:pfam05109 534 ATSptlGKTSPTSAVTTPTP------NATSPTPAVT-----TPTPNATIPTLGKTSPTSAVTTPTPNATSpTVGETSPQA 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  339 SKINEVLTAAVTQASLQSIIHKFLTAGPSA-FNITSLISQAAQLSTQAQPSNQSPmSLTSDASSPRSYVSPRISTPQTNT 417
Cdd:pfam05109 603 NTTNHTLGGTSSTPVVTSPPKNATSAVTTGqHNITSSSTSSMSLRPSSISETLSP-STSDNSTSHMPLLTSAHPTGGENI 681

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  418 VPIKPL-ISTPPVSSQ---PKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSSNASN 493
Cdd:pfam05109 682 TQVTPAsTSTHHVSTSspaPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANST 761


                  ..
gi 982942573  494 TA 495
Cdd:pfam05109 762 TG 763
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 88-115 3.14e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 3.14e-09
                          10        20
                  ....*....|....*....|....*...
gi 982942573   88 DDWSEHISSSGKKYYYNCRTEVSQWEKP 115
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 88-117 1.10e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.99  E-value: 1.10e-08
                         10        20        30
                 ....*....|....*....|....*....|
gi 982942573  88 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 117
Cdd:cd00201    2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-512 9.42e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 9.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  190 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGastlsklPTPTSSVPAQRTERKESTSGDKA 269
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDD-------PAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  270 VSHSCTTPSTSSASGLNPTSA----PPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVL 345
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  346 TAAVTQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPI 420
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPT 2837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  421 KPLISTPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVspRSLQRSNSQRSPSPGPnhtsssnasntavVPQ 499
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPV--RRLARPAVSRSTESFA-------------LPP 2902

                         330
                  ....*....|...
gi 982942573  500 NSSARPPCSLTPT 512
Cdd:PHA03247 2903 DQPERPPQPQAPP 2915
PHA03247 PHA03247
large tegument protein UL36; Provisional
 189-513 6.91e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 6.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  189 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQRTERKESTSGDK 268
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  269 AVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLlqdpnllrqllPALQATLQLNNSNVDISKINEVLTAA 348
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----------GPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  349 VTQASlqsiihkflTAGPSAFNITSLISQAAQLSTQ--AQPSNQSPMSLTSDASSPrsyvspristPQTNTVPIKPLIST 426
Cdd:PHA03247 2870 SPAAK---------PAAPARPPVRRLARPAVSRSTEsfALPPDQPERPPQPQAPPP----------PQPQPQPPPPPQPQ 2930

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  427 PPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGH----EPVSPRSLQRSNSQRSPSPGPNHTSSSNASNTAVVPQNSS 502
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAlvpgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010

                         330
                  ....*....|....*...
gi 982942573  503 -------ARPPCSLTPTL 513
Cdd:PHA03247 3011 lalheetDPPPVSLKQTL 3028
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 90-117 1.11e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.11e-06
                           10        20
                   ....*....|....*....|....*...
gi 982942573    90 WSEHISSSGKKYYYNCRTEVSQWEKPKE 117
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 177-516 1.59e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  177 SQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPftlqsdhQPKKSFDANGASTLSKLPTPTSSVPA- 255
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP-------GPAAARQASPALPAAPAPPAVPAGPAt 2750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  256 ----QRTERKESTSGDKAvshscTTPSTSSASGLNPTSAPPASASAIPVSPvpQSPIPPLLQDPNLlrqllPALQATLQL 331
Cdd:PHA03247 2751 pggpARPARPPTTAGPPA-----PAPPAAPAAGPPRRLTRPAVASLSESRE--SLPSPWDPADPPA-----AVLAPAAAL 2818

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  332 NNSNVDISKINEVLTAAVTQASLqsiihkflTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSP--RSYVSPR 409
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPP--------PPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPpvRRLARPA 2890

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  410 IStPQTNTVPIKPLISTPPvsSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSS 489
Cdd:PHA03247 2891 VS-RSTESFALPPDQPERP--PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967

                         330       340       350
                  ....*....|....*....|....*....|..
gi 982942573  490 NASNTAV----VPQNSSARP-PCSLTPTLAAH 516
Cdd:PHA03247 2968 VPGRVAVprfrVPQPAPSREaPASSTPPLTGH 2999
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 382-544 4.13e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  382 STQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPV-SSQPKVSTPVVKQGPVSQSATQQPVTADKQQ 460
Cdd:PRK10263  299 ATQPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVaSVDVPPAQPTVAWQPVPGPQTGEPVIAPAPE 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  461 GHEPVsPRSLQRSNSQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPAdHAEKQASRL 540
Cdd:PRK10263  379 GYPQQ-SQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAW-QAEEQQSTF 456


                  ....
gi 982942573  541 REEA 544
Cdd:PRK10263  457 APQS 460
PRP40 COG5104
Splicing factor [RNA processing and modification];
87-123 6.48e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.76  E-value: 6.48e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 982942573  87 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 123
Cdd:COG5104   14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
86-153 2.54e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.83  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  86 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 151
Cdd:COG5104   54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                 ..
gi 982942573 152 TS 153
Cdd:COG5104  134 TS 135
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 189-495 5.60e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  189 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTL----QSDHQPKKSFDANGASTLSKLPTP--TSSVPAQRTERKE 262
Cdd:pfam05109 454 VPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPspspRDNGTESKAPDMTSPTSAVTTPTPnaTSPTPAVTTPTPN 533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  263 STS---GDKAVSHSCTTPSTssasglNPTSAPPASAsaipvSPVPQSPIPPLLQDPNLLRQLLPALQATL-QLNNSNVDI 338
Cdd:pfam05109 534 ATSptlGKTSPTSAVTTPTP------NATSPTPAVT-----TPTPNATIPTLGKTSPTSAVTTPTPNATSpTVGETSPQA 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  339 SKINEVLTAAVTQASLQSIIHKFLTAGPSA-FNITSLISQAAQLSTQAQPSNQSPmSLTSDASSPRSYVSPRISTPQTNT 417
Cdd:pfam05109 603 NTTNHTLGGTSSTPVVTSPPKNATSAVTTGqHNITSSSTSSMSLRPSSISETLSP-STSDNSTSHMPLLTSAHPTGGENI 681

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573  418 VPIKPL-ISTPPVSSQ---PKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSSNASN 493
Cdd:pfam05109 682 TQVTPAsTSTHHVSTSspaPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANST 761


                  ..
gi 982942573  494 TA 495
Cdd:pfam05109 762 TG 763
PRK13914 PRK13914
invasion associated endopeptidase;
381-512 6.55e-03

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 39.40  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982942573 381 LSTQAQPSNQSPMSLtSDASSPRSYVSPRISTPQT-NTVPIKPLISTPPVSSQpKVSTPVVKQGPVSQSATQQPVTADKQ 459
Cdd:PRK13914 213 LSVKYGVSVQDIMSW-NNLSSSSIYVGQKLAIKQTaNTATPKAEVKTEAPAAE-KQAAPVVKENTNTNTATTEKKETTTQ 290

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982942573 460 QGHEPVSPRSLQRSnsqrSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPT 512
Cdd:PRK13914 291 QQTAPKAPTEAAKP----APAPSTNTNANKTNTNTNTNTNNTNTSTPSKNTNT 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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