|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1514-1649 |
9.16e-90 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 287.15 E-value: 9.16e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1514 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1593
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767904868 1594 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1649
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1159-1243 |
1.92e-35 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 129.92 E-value: 1.92e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1159 VVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLT 1238
Cdd:pfam00030 3 VLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIG 77
|
....*
gi 767904868 1239 SLRVI 1243
Cdd:pfam00030 78 SLRPI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1252-1332 |
2.36e-29 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 112.59 E-value: 2.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1252 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1331
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904868 1332 V 1332
Cdd:pfam00030 82 I 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1159-1243 |
4.49e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.05 E-value: 4.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1159 VVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLT 1238
Cdd:smart00247 3 TLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQIS 77
|
....*
gi 767904868 1239 SLRVI 1243
Cdd:smart00247 78 SIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1432-1512 |
5.27e-25 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 99.88 E-value: 5.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1432 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1510
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 767904868 1511 PI 1512
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1075-1155 |
9.43e-22 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 90.63 E-value: 9.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904868 1155 M 1155
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1345-1424 |
5.43e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.93 E-value: 5.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1345 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1421
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 767904868 1422 QKV 1424
Cdd:pfam00030 80 RPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1433-1512 |
2.54e-17 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 78.32 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1433 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1511
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 767904868 1512 I 1512
Cdd:smart00247 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
987-1066 |
2.29e-15 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 72.53 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 987 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1061
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77
|
....*
gi 767904868 1062 SLRRV 1066
Cdd:pfam00030 78 SLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1345-1421 |
5.05e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.77 E-value: 5.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1345 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1421
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1252-1332 |
6.38e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1252 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1331
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904868 1332 V 1332
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
248-710 |
1.64e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.97 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 248 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 327
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 328 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 402 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 476
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 477 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 553
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 554 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 627
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 705
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018
|
....*
gi 767904868 706 PAPSS 710
Cdd:PHA03247 3019 PPPVS 3023
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
987-1066 |
7.65e-11 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 59.83 E-value: 7.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 987 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1061
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77
|
....*
gi 767904868 1062 SLRRV 1066
Cdd:smart00247 78 SIRRI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1075-1155 |
6.88e-10 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 57.13 E-value: 6.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904868 1155 M 1155
Cdd:smart00247 82 I 82
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
293-742 |
1.21e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.85 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 293 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 369
Cdd:pfam05109 445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 370 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 449
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 450 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 525
Cdd:pfam05109 568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 526 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 605
Cdd:pfam05109 648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 606 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 682
Cdd:pfam05109 715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 683 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 742
Cdd:pfam05109 785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1557-1644 |
5.93e-06 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 47.14 E-value: 5.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1557 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1634
Cdd:pfam00652 40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
|
90
....*....|
gi 767904868 1635 PDEDRASQIW 1644
Cdd:pfam00652 117 CDSGNPNQQW 126
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| beta-trefoil_Ricin_CRYBG2 |
cd23465 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1514-1649 |
9.16e-90 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467343 Cd Length: 136 Bit Score: 287.15 E-value: 9.16e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1514 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1593
Cdd:cd23465 1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767904868 1594 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1649
Cdd:cd23465 81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
|
|
| beta-trefoil_Ricin_CRYBG |
cd23430 |
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ... |
1517-1648 |
5.26e-75 |
|
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467308 [Multi-domain] Cd Length: 133 Bit Score: 244.81 E-value: 5.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1517 VYFRLWNAALGGFLAVPDHVEDmKAGRVVVADPQAG-GSCIWYYEDGLLKNQMAPTMSLQVIGPPS-PGSKVVLWAESRL 1594
Cdd:cd23430 1 VYFRLRNKATGLFLSVNGNLED-LKLLRVQVMPDVGaDDQIWYYQEGLIKCRIAEDCCLTVIGSLVtPGSKVGLWLEQNA 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 767904868 1595 PRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHV 1648
Cdd:cd23430 80 DRQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVWEIMV 133
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1159-1243 |
1.92e-35 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 129.92 E-value: 1.92e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1159 VVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLT 1238
Cdd:pfam00030 3 VLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIG 77
|
....*
gi 767904868 1239 SLRVI 1243
Cdd:pfam00030 78 SLRPI 82
|
|
| beta-trefoil_Ricin_vlAKAP |
cd23463 |
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ... |
1514-1649 |
2.54e-33 |
|
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467341 Cd Length: 136 Bit Score: 126.01 E-value: 2.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1514 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVAdpQAGGSC--IWYYEDGLLKNQMAPTmSLQVIG-PPSPGSKVVLWA 1590
Cdd:cd23463 1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVS--QYNGKDtqIWYYCRGLLKSKANDA-CLDVIGgKDNPGSKVALWT 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 767904868 1591 ESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1649
Cdd:cd23463 78 EHGKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKWDIELL 136
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1252-1332 |
2.36e-29 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 112.59 E-value: 2.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1252 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1331
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904868 1332 V 1332
Cdd:pfam00030 82 I 82
|
|
| beta-trefoil_Ricin_CRYBG1 |
cd23464 |
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ... |
1514-1649 |
2.99e-27 |
|
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467342 Cd Length: 137 Bit Score: 108.35 E-value: 2.99e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1514 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGP-PSPGSKVVLWAES 1592
Cdd:cd23464 1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNlVTAGSKLGLSLEQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767904868 1593 RLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1649
Cdd:cd23464 81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1159-1243 |
4.49e-27 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 106.05 E-value: 4.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1159 VVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLT 1238
Cdd:smart00247 3 TLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQIS 77
|
....*
gi 767904868 1239 SLRVI 1243
Cdd:smart00247 78 SIRRI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1432-1512 |
5.27e-25 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 99.88 E-value: 5.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1432 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1510
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80
|
..
gi 767904868 1511 PI 1512
Cdd:pfam00030 81 PI 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1075-1155 |
9.43e-22 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 90.63 E-value: 9.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:pfam00030 2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81
|
.
gi 767904868 1155 M 1155
Cdd:pfam00030 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
1345-1424 |
5.43e-19 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 82.93 E-value: 5.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1345 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1421
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79
|
...
gi 767904868 1422 QKV 1424
Cdd:pfam00030 80 RPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1433-1512 |
2.54e-17 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 78.32 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1433 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1511
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81
|
.
gi 767904868 1512 I 1512
Cdd:smart00247 82 I 82
|
|
| Crystall |
pfam00030 |
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ... |
987-1066 |
2.29e-15 |
|
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.
Pssm-ID: 459639 Cd Length: 82 Bit Score: 72.53 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 987 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1061
Cdd:pfam00030 1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77
|
....*
gi 767904868 1062 SLRRV 1066
Cdd:pfam00030 78 SLRPI 82
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1345-1421 |
5.05e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.77 E-value: 5.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1345 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1421
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1252-1332 |
6.38e-15 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 71.39 E-value: 6.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1252 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1331
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904868 1332 V 1332
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
248-710 |
1.64e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.97 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 248 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 327
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 328 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 402 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 476
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 477 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 553
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 554 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 627
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 705
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018
|
....*
gi 767904868 706 PAPSS 710
Cdd:PHA03247 3019 PPPVS 3023
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
987-1066 |
7.65e-11 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 59.83 E-value: 7.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 987 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1061
Cdd:smart00247 1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77
|
....*
gi 767904868 1062 SLRRV 1066
Cdd:smart00247 78 SIRRI 82
|
|
| beta-trefoil_Ricin_SCDase |
cd23456 |
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ... |
1518-1644 |
2.13e-10 |
|
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.
Pssm-ID: 467334 [Multi-domain] Cd Length: 122 Bit Score: 59.68 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1518 YFRLWNAALGGFLAVPDHVedMKAGRVVVADPQAGGSCIWYYE-DGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPR 1596
Cdd:cd23456 2 YFQLKSQASGLCLDVSGGA--TNGANVVVYDCNNSNSQKWYYDaTGRLHSKANPGKCLDAGGENSNGANVVLWACNDSAN 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767904868 1597 QTWSIsESGHICSQMFEGQILDVKGGRGydrDHVVLWEPDEDrASQIW 1644
Cdd:cd23456 80 QRWDF-DGNFIRSRNNTNLALDAYGSQG---SNVGLWQFHGG-ANQQW 122
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
335-866 |
4.90e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 4.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 335 PSSTELPLQTSQgQASVPSSPRLETHVPSPGLTHPAKQPVVPTHP--GARLTPLVLPPKKKDGPVDPPAATvlPMVRSEH 412
Cdd:PHA03247 2561 PAAPDRSVPPPR-PAPRPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPS--PSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 413 VTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVlpftqrevvKGPGAPAASSPTRKEVVQGSSASAASSP 492
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP---------QRPRRRAARPTVGSLTSLADPPPPPPTP 2708
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 493 twkEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDAsfPTWKEVVKGPGAPAASSPTQKEVvqgsGAP 572
Cdd:PHA03247 2709 ---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG--PARPARPPTTAGPPAPAPPAAPA----AGP 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 573 AALSTTPKEVVKGPGAPAASSPtqkevvKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIA 652
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSP------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 653 GSLAP--PLTKEETVQGPIAPATSLPKqdkgvqdsegSPISSLTQKEVVQDPDALPAPSSSVDRvSPSPGGTPAPVPTGA 730
Cdd:PHA03247 2854 GSVAPggDVRRRPPSRSPAAKPAAPAR----------PPVRRLARPAVSRSTESFALPPDQPER-PPQPQAPPPPQPQPQ 2922
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 731 EASTESQLVSDPTEGKtctetsreedevalaadleifldtlrsmePPEilrthrlPRAPRSSYLSMYATLPAIEEDQLGP 810
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPR-----------------------------PQP-------PLAPTTDPAGAGEPSGAVPQPWLGA 2966
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 767904868 811 WVlgPGPQEVPsleekeeeeeeepenpylsddeklqrRQEKAGPSPSRDLhPARPT 866
Cdd:PHA03247 2967 LV--PGRVAVP--------------------------RFRVPQPAPSREA-PASST 2993
|
|
| XTALbg |
smart00247 |
Beta/gamma crystallins; Beta/gamma crystallins |
1075-1155 |
6.88e-10 |
|
Beta/gamma crystallins; Beta/gamma crystallins
Pssm-ID: 214583 Cd Length: 82 Bit Score: 57.13 E-value: 6.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:smart00247 2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81
|
.
gi 767904868 1155 M 1155
Cdd:smart00247 82 I 82
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
103-742 |
6.21e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 6.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 103 PPPKekrPEGRLKEAVDQS-DGSRQAPRTEPPCVGAMARTELLVPLPG-PREPsphpgvgltsgssrsleeyrvtrtvrt 180
Cdd:PHA03247 2552 PPPL---PPAAPPAAPDRSvPPPRPAPRPSEPAVTSRARRPDAPPQSArPRAP--------------------------- 2601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 181 ttvvgghVDRRMSSSVTVRPVSsgealprgrqvsrmvppvvvgsppgspsrsqavkvlsnlvpaghSPPASHLPRPTAGG 260
Cdd:PHA03247 2602 -------VDDRGDPRGPAPPSP--------------------------------------------LPPDTHAPDPPPPS 2630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 261 PRSTGlgstvgaalRQLPETGTAELKDSSALASTGIPASAHLPKNQdapaacpdRDQGRAPDARA-CELWQVLGAPSSTe 339
Cdd:PHA03247 2631 PSPAA---------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--------RRLGRAAQASSpPQRPRRRAARPTV- 2692
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 340 lplqtsqgqASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTPLVLPPKKKD-GPVDPPAATVLPMVrsehVTVPGQ 418
Cdd:PHA03247 2693 ---------GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGG----PARPAR 2759
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 419 PPAPSTTRRKDVPS-PGGLSAPSSPRNKFVQNSENVPVLPFTqrevvKGPGAPAASSPTRKEVVQGSSASAASSPTWKEV 497
Cdd:PHA03247 2760 PPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 498 VKGPGAPAASSPTQKEVVQGSSAPAALF---PTWKEVVKGPGAP----------------DASFPTWKEVVKGPGAPAAS 558
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPAAParppvrrlarpavsrsTESFALPPDQPERPPQPQAP 2914
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 559 SPTQKevvQGSGAPAALSTTPKEVVKGPGAPAAssPTQKEVVKGPCAPAASSPTQKEVVQGS-GAPAALSPKSTEVVQGP 637
Cdd:PHA03247 2915 PPPQP---QPQPPPPPQPQPPPPPPPRPQPPLA--PTTDPAGAGEPSGAVPQPWLGALVPGRvAVPRFRVPQPAPSREAP 2989
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 638 KGSSSIQKE----AVQGIAGSLApplTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEVVQDPDALPAPSSSVD 713
Cdd:PHA03247 2990 ASSTPPLTGhslsRVSSWASSLA---LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPF 3066
|
650 660
....*....|....*....|....*....
gi 767904868 714 RVSPSPgGTPApvpTGAEASTESQLVSDP 742
Cdd:PHA03247 3067 AHEPDP-ATPE---AGARESPSSQFGPPP 3091
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
293-742 |
1.21e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.85 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 293 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 369
Cdd:pfam05109 445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 370 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 449
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 450 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 525
Cdd:pfam05109 568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 526 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 605
Cdd:pfam05109 648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 606 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 682
Cdd:pfam05109 715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 683 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 742
Cdd:pfam05109 785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
331-866 |
1.24e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.87 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 331 VLGAPSSTEL---------PLQTSQGQASVPSSPRletHVPSPGLTHPaKQPVVPTHPGaRLTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2459 ILGAPFSLSLllgelfpgaPVYRRPAEARFPFAAG---AAPDPGGGGP-PDPDAPPAPS-RLAPAILPDEPVGEPVHPRM 2533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 402 ATVLPMVRSEHVTVPGQPP------APSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 475
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPpplppaAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 476 TrkevvqgssasaasSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAalfPTWKEVVKGPGAPDASFPtwKEVVKGPGAP 555
Cdd:PHA03247 2614 P--------------SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPAPGRVSRP--RRARRLGRAA 2674
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 556 AASSPTQKEVVQGSGAPAAlSTTPKEVVKGPGAPAASSPTqkevvkgPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQ 635
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVG-SLTSLADPPPPPPTPEPAPH-------ALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 636 GPKGSSSIQKEAvqgiagslAPPLTkeetvQGPIAPATSlpkqdkgvQDSEGSPISSLTQKEVV---QDPDALPAPSSSV 712
Cdd:PHA03247 2747 GPATPGGPARPA--------RPPTT-----AGPPAPAPP--------AAPAAGPPRRLTRPAVAslsESRESLPSPWDPA 2805
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 713 DRVSPSPGGTPAPVPTGAEAS-----TESQLVSDPTEGKTCTETSREEDEVALAADLEifldtlRSMEPPEILRTHRLPR 787
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGplpppTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR------RRPPSRSPAAKPAAPA 2879
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767904868 788 APRSSYLSMYATLPAIEEDQLGPwvLGPGPQEVPSLEEKeeeeeeepenPYLSDDEKLQRRQEKAGPSPSRDLHPARPT 866
Cdd:PHA03247 2880 RPPVRRLARPAVSRSTESFALPP--DQPERPPQPQAPPP----------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
|
|
| beta-trefoil_Ricin-like |
cd00161 |
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ... |
1518-1644 |
2.03e-06 |
|
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.
Pssm-ID: 467293 [Multi-domain] Cd Length: 134 Bit Score: 48.91 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1518 YFRLWNAALGGFLAVPDHveDMKAG-RVVVADPQAGGSCIWYYED-----GLLKNqMAPTMSLQVIG-PPSPGSKVVLWA 1590
Cdd:cd00161 2 TYRIVNAASGKCLDVAGG--STANGaPVQQWTCNGGANQQWTLTPvgdgyYTIRN-VASGKCLDVAGgSTANGANVQQWT 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 767904868 1591 ESRLPRQTWSISESG----HICSQMfEGQILDVKGGRGYDRDHVVLWePDEDRASQIW 1644
Cdd:cd00161 79 CNGGDNQQWRLEPVGdgyyRIVNKH-SGKCLDVSGGSTANGANVQQW-TCNGGANQQW 134
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
261-767 |
2.29e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 52.68 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 261 PRSTGLGSTVGAAL----RQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAAcpdrDQGRAPDARAcelwqvlgAPS 336
Cdd:PRK07764 365 PSASDDERGLLARLerleRRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAA----AAAPAPAAAP--------QPA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 337 STELPLQTSQGQASVPSSPRLETHVPSPGLT-HPAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTV 415
Cdd:PRK07764 433 PAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSaQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 416 PGQPPAPSTTRRKDVPSPGGLSAPssprnkfvqnseNVPVLPFTQREVV----KGPGAPAASSPTRKEVVQGSSASAASS 491
Cdd:PRK07764 513 RERWPEILAAVPKRSRKTWAILLP------------EATVLGVRGDTLVlgfsTGGLARRFASPGNAEVLVTALAEELGG 580
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 492 pTWK-EVVKGPGAPAASSPTQKEVVQGSSAPAALFPTwkevvkgpgAPDAsfptwkevvkgPGAPAASSPTqkevvQGSG 570
Cdd:PRK07764 581 -DWQvEAVVGPAPGAAGGEGPPAPASSGPPEEAARPA---------APAA-----------PAAPAAPAPA-----GAAA 634
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 571 APAALSTTpkevvkgPGAPAASSPTQKEVVKGPCAPAASSPTQKEVvqGSGAPAALSPKSTEVVQGPKGSSSiqkeavqg 650
Cdd:PRK07764 635 APAEASAA-------PAPGVAAPEHHPKHVAVPDASDGGDGWPAKA--GGAAPAAPPPAPAPAAPAAPAGAA-------- 697
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 651 iAGSLAPPLTKEETVQGPIAPATSLPKQDKG-VQDSEGSPISSLTQKEVVQDPDALPAPSSSVDRVSPSPGGTPAPVPTG 729
Cdd:PRK07764 698 -PAQPAPAPAATPPAGQADDPAAQPPQAAQGaSAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
|
490 500 510
....*....|....*....|....*....|....*...
gi 767904868 730 AEASTESQLVSDPTEGkTCTETSREEDEVALAADLEIF 767
Cdd:PRK07764 777 SPPSEEEEMAEDDAPS-MDDEDRRDAEEVAMELLEEEL 813
|
|
| Ricin_B_lectin |
pfam00652 |
Ricin-type beta-trefoil lectin domain; |
1557-1644 |
5.93e-06 |
|
Ricin-type beta-trefoil lectin domain;
Pssm-ID: 395527 [Multi-domain] Cd Length: 126 Bit Score: 47.14 E-value: 5.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1557 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1634
Cdd:pfam00652 40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
|
90
....*....|
gi 767904868 1635 PDEDRASQIW 1644
Cdd:pfam00652 117 CDSGNPNQQW 126
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
307-742 |
6.60e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.33 E-value: 6.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 307 DAPAACPDRDQGRAPDARACeLWQVLGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPvvPTHPGARLTPL 386
Cdd:PHA03307 47 SAELAAVTVVAGAAACDRFE-PPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPP 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 387 VLPPKkkdgPVDPPAATVLPMVRSeHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKG 466
Cdd:PHA03307 124 ASPPP----SPAPDLSEMLRPVGS-PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 467 PGAPAASSPTRKEVVQGSSASAASSPTwkevvKGPGAPAASSPTqkevvqGSSAPAALFPTWKEVVKGPGAPDASF--PT 544
Cdd:PHA03307 199 PAAASPRPPRRSSPISASASSPAPAPG-----RSAADDAGASSS------DSSSSESSGCGWGPENECPLPRPAPItlPT 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 545 WKEVVKGPGAPAASSPTQKEvvqgSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA 624
Cdd:PHA03307 268 RIWEASGWNGPSSRPGPASS----SSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 625 ALSPKStevvqGPKGSSSiqkeavqgiAGSLAPPLTKEETVQGPIAPATSLPKqdkgvqdseGSPISSLTQKevvqdpdA 704
Cdd:PHA03307 344 GPSPSR-----SPSPSRP---------PPPADPSSPRKRPRPSRAPSSPAASA---------GRPTRRRARA-------A 393
|
410 420 430
....*....|....*....|....*....|....*...
gi 767904868 705 LPAPSSSVDRVSPSPGGTPAPVPTGAEASTESQLVSDP 742
Cdd:PHA03307 394 VAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYP 431
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
248-624 |
9.11e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 50.84 E-value: 9.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 248 PPASHLPRPTAGGP---------RSTGLGSTVGAALRQLPETGTAELK------DSSALASTGIPASAHLPKNQDAPAAC 312
Cdd:PHA03378 526 PPSPPQPRAGRRAPcvytedldiESDEPASTEPVHDQLLPAPGLGPLQiqpltsPTTSQLASSAPSYAQTPWPVPHPSQT 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 313 PD--RDQGRAPDARACELWQVLGAPSSTElPLQTSQGQASVP------SSPRLETHVPSPGLTHPAKQPVVPTHPGARLT 384
Cdd:PHA03378 606 PEppTTQSHIPETSAPRQWPMPLRPIPMR-PLRMQPITFNVLvfptphQPPQVEITPYKPTWTQIGHIPYQPSPTGANTM 684
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 385 plvLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKD-------VPSPGGLSAPSSPRNKFVQNSENVPVLP 457
Cdd:PHA03378 685 ---LPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaaapgrARPPAAAPGRARPPAAAPGRARPPAAAP 761
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 458 FTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPTWKE-------VVKGPGAPAASSPTQKEVVQG------SSAPAAL 524
Cdd:PHA03378 762 GRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPqagptsmQLMPRAAPGQQGPTKQILRQLltggvkRGRPSLK 841
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 525 FPTWKEVVKGPG-APDASFPTWKEVVKGP-GAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKG 602
Cdd:PHA03378 842 KPAALERQAAAGpTPSPGSGTSDKIVQAPvFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGVGPMHPTDIPP 921
|
410 420
....*....|....*....|..
gi 767904868 603 PCAPAASSPTQKEVVQGSGAPA 624
Cdd:PHA03378 922 SKRAKTDAYVESQPPHGGQSHS 943
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
473-743 |
2.48e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.14 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 473 SSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPG---------APDASFP 543
Cdd:pfam05109 430 TSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSprdngteskAPDMTSP 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 544 TWKEVVKGPGA----PAASSPTQKevvqgSGAPAALSTTPKEVVKGPgAPAASSPTqkevvkgpcaPAASSPTQKEVVQG 619
Cdd:pfam05109 510 TSAVTTPTPNAtsptPAVTTPTPN-----ATSPTLGKTSPTSAVTTP-TPNATSPT----------PAVTTPTPNATIPT 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 620 SGAPaalSPKSTEVVQGPKGSSSiqkeavqgIAGSLAPPL-TKEETVQGPIAP--ATSLPKQDKGVQDSEGSPISSLTQK 696
Cdd:pfam05109 574 LGKT---SPTSAVTTPTPNATSP--------TVGETSPQAnTTNHTLGGTSSTpvVTSPPKNATSAVTTGQHNITSSSTS 642
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 767904868 697 EVVQDPDALP---APSSSVDRVSPSPGGTPAPvPTGAEASTESQLVSDPT 743
Cdd:pfam05109 643 SMSLRPSSISetlSPSTSDNSTSHMPLLTSAH-PTGGENITQVTPASTST 691
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
369-594 |
4.23e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.33 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 369 PAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQ-PPAP---STTRRKDVPSPGGLSAPSSprn 444
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrSPAPealAAARQASARGPGGAPAPAP--- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 445 kfvqNSENVPVlpftqrevvkGPGAPAASSPtrkevvqgssasaassptwkevvKGPGAPAASSPTQKEVVQGSSAPAAL 524
Cdd:PRK12323 453 ----APAAAPA----------AAARPAAAGP-----------------------RPVAAAAAAAPARAAPAAAPAPADDD 495
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767904868 525 FPTWKEV-----VKGPGAPDASFPTW-KEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSP 594
Cdd:PRK12323 496 PPPWEELppefaSPAPAQPDAAPAGWvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
|
|
| beta-trefoil_Ricin_SCDase_rpt1 |
cd23499 |
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ... |
1518-1644 |
7.19e-05 |
|
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket. The model corresponds to the first lectin domain.
Pssm-ID: 467377 [Multi-domain] Cd Length: 131 Bit Score: 44.36 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1518 YFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCI--WYY--EDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1593
Cdd:cd23499 2 FVRIVNRASGKCLDIPGNDNDVVNGANVILWDCADKSADqrWIYdaASGMLRNKANPSYCLDNRGQAYNGGEVVLWQCED 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 767904868 1594 LPRQTWSISeSGHICSQMFEGQILDVkGGRGYDrDHVVLWEpDEDRASQIW 1644
Cdd:cd23499 82 SDNLRWTYD-NGVLRSKHNPNIVLDA-YGRDNN-SQVGQWE-YHGGANQQW 128
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
500-766 |
7.73e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.56 E-value: 7.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 500 GPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVkgpGAPAASSPtqkevvqgsgAPAALSTTP 579
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA---AAPARRSP----------APEALAAAR 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 580 KEVVKGPGAPAASSPTQkevvkgPCAPAASSPTQKEVVQGSGAPAALSPksteVVQGPKGSSSIQKEAVqgiagslaPPL 659
Cdd:PRK12323 438 QASARGPGGAPAPAPAP------AAAPAAAARPAAAGPRPVAAAAAAAP----ARAAPAAAPAPADDDP--------PPW 499
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 660 tkEETvqGPIAPATSLPKQDKGVQDSEGSPISsltqKEVVQDPDAlpapsssvDRVSPSPGGTPAPVPTGAEASTESQLV 739
Cdd:PRK12323 500 --EEL--PPEFASPAPAQPDAAPAGWVAESIP----DPATADPDD--------AFETLAPAPAAAPAPRAAAATEPVVAP 563
|
250 260
....*....|....*....|....*..
gi 767904868 740 SDPTEGKTCTETSREEDEVALAADLEI 766
Cdd:PRK12323 564 RPPRASASGLPDMFDGDWPALAARLPV 590
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
362-603 |
8.64e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 47.38 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 362 PSPGLTH-PAKQPVVPTHPGArltplvlpPKKKDGPVDP--PAATVLPMVRSEhvtvPGQPPAPSTTRRKDVP-SPGGLS 437
Cdd:PTZ00449 561 PGPAKEHkPSKIPTLSKKPEF--------PKDPKHPKDPeePKKPKRPRSAQR----PTRPKSPKLPELLDIPkSPKRPE 628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 438 APSSPRNkfvqnsenvPVLPftQRevvkgpgapaASSPTRKEvvqgssasaasSPTWKEVVKGPGAPAAS-SPTQKEVVQ 516
Cdd:PTZ00449 629 SPKSPKR---------PPPP--QR----------PSSPERPE-----------GPKIIKSPKPPKSPKPPfDPKFKEKFY 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 517 GSSAPAAlfPTWKEVVKGPGAPDASFPTWKEVVkgPGAPAASSPTQKEVvqgsgaPAALSTTPKEVVKGPGAPAASSPTQ 596
Cdd:PTZ00449 677 DDYLDAA--AKSKETKTTVVLDESFESILKETL--PETPGTPFTTPRPL------PPKLPRDEEFPFEPIGDPDAEQPDD 746
|
....*..
gi 767904868 597 KEVVKGP 603
Cdd:PTZ00449 747 IEFFTPP 753
|
|
| beta-trefoil_Ricin_GllA-1 |
cd23454 |
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ... |
1543-1646 |
8.97e-05 |
|
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.
Pssm-ID: 467332 [Multi-domain] Cd Length: 136 Bit Score: 44.23 E-value: 8.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 1543 RVVVAD--PQAGGSCIWYYEDGLLKNQMaptmSLQVI----GPPSPGSKVVLWAESRLPR---QTWSISESGHICSQMFE 1613
Cdd:cd23454 26 KVVLAPlkTKDYESQLWRYDDGYLVNKA----SGLVLdiqgGVVKSGTRLVQSPKKPSKDannQRWGLTADGYIYLLSNP 101
|
90 100 110
....*....|....*....|....*....|....*
gi 767904868 1614 GQILDVKGGRGYDRDHVVLWE--PDEDRASQIWTI 1646
Cdd:cd23454 102 SLVLGIKGNETREGARVILQErkLQKDALNQRWTF 136
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
532-733 |
1.14e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 47.15 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 532 VKGPGAPDASFPTwkEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSP 611
Cdd:PRK07003 362 VTGGGAPGGGVPA--RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 612 TQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEEtvqgPIAPATSLPKQDKGVQDSEGSPIS 691
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE----PAPRAAAPSAATPAAVPDARAPAA 515
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 767904868 692 SLTQKEVVqdPDALPAPSSSvdrvSPSPG-GTPAPVPTGAEAS 733
Cdd:PRK07003 516 ASREDAPA--AAAPPAPEAR----PPTPAaAAPAARAGGAAAA 552
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
248-686 |
1.65e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.52 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 248 PPASHLPRPTAGGPRSTGlgstVGAALRQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAACPDRDQGRAPDARAce 327
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAA----AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA-- 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 328 lwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTP------LVLPPKKKDGPVDP-- 399
Cdd:PRK07764 460 -----AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeILAAVPKRSRKTWAil 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 400 -PAATVLpMVRSEHVTVpgqppapsttrrkDVPSPGGLSAPSSPRN--KFVQNSENVPVLPFtQREVVKGPGAPAASSPT 476
Cdd:PRK07764 535 lPEATVL-GVRGDTLVL-------------GFSTGGLARRFASPGNaeVLVTALAEELGGDW-QVEAVVGPAPGAAGGEG 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 477 RKEVVQgssasaassPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKE--------VVKGPGAPDASFPTWKEV 548
Cdd:PRK07764 600 PPAPAS---------SGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgvaapehHPKHVAVPDASDGGDGWP 670
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 549 VK-GPGAPAASSPTQKEVVQGSGAPAAlsttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKevVQGSGAPAALS 627
Cdd:PRK07764 671 AKaGGAAPAAPPPAPAPAAPAAPAGAA----PAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP--AADDPVPLPPE 744
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 767904868 628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSlPKQDKGVQDSE 686
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAP-SMDDEDRRDAE 802
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
433-726 |
1.89e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.38 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 433 PGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPtwkevvKGPGAPAASSPTQK 512
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP------AAPAPPATADRGDD 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 513 EVVQGSSAPAALfPTWKEVVKGPGAPDASFPTWKEVVKGPgAPAASSPTQKE------VVQGSGAPAALSTTPKEVVKGP 586
Cdd:PRK07003 442 AADGDAPVPAKA-NARASADSRCDERDAQPPADSGSASAP-ASDAPPDAAFEpapraaAPSAATPAAVPDARAPAAASRE 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 587 GAPAASSPTQKEVvkGPCAPAASSPTQKevvqGSGAPAAL-----------SPKSTEVVQGPK---GSSSIQKEAVQGIA 652
Cdd:PRK07003 520 DAPAAAAPPAPEA--RPPTPAAAAPAAR----AGGAAAALdvlrnagmrvsSDRGARAAAAAKpaaAPAAAPKPAAPRVA 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 653 GSLAPPLTKEETVQGPIAPATSLPKQdkgvQDSEGSP----------ISSLTQKEVVQDPDA--LPAPSSSVD--RVSPS 718
Cdd:PRK07003 594 VQVPTPRARAATGDAPPNGAARAEQA----AESRGAPppwedippddYVPLSADEGFGGPDDgfVPVFDSGPDdvRVAPK 669
|
....*...
gi 767904868 719 PGGTPAPV 726
Cdd:PRK07003 670 PADAPAPP 677
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
466-674 |
6.58e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.48 E-value: 6.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 466 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQG----SSAPAALFPTWKEVVKGPGAPDAS 541
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAparrSPAPEALAAARQASARGPGGAPAP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 542 FPTwkevvkgpgAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEvvqGSG 621
Cdd:PRK12323 451 APA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD---AAP 518
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767904868 622 APAALSPKSTEVVQGPKGSSSIQKEAvqGIAGSLAPPLTKEETVQGPIAPATS 674
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPA--PAAAPAPRAAAATEPVVAPRPPRAS 569
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
344-676 |
9.01e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 44.28 E-value: 9.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 344 TSQGQASVPSSPrlETHVPSPGLTH--------PAKQ----PVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSE 411
Cdd:PHA03379 435 TSHGSAQVPEPP--PVHDLEPGPLHdqhsmapcPVAQlppgPLQDLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEAS 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 412 HVTVPGQPPAPSttrrkdvpSPGGLSAPSSPRNKFVQNSenvPVLPFTQREVVKGPGAPAASSPTRKevvqgssasaass 491
Cdd:PHA03379 513 LSQVPGVAFAPV--------MPQPMPVEPVPVPTVALER---PVCPAPPLIAMQGPGETSGIVRVRE------------- 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 492 pTWKEVVKGPGAPAASSPTQ--------KEVVQGSSAPAALFPTwkEVVKGPGAPDASFPTWKEVVKGPGAPAASSPtqk 563
Cdd:PHA03379 569 -RWRPAPWTPNPPRSPSQMSvrdrlarlRAEAQPYQASVEVQPP--QLTQVSPQQPMEYPLEPEQQMFPGSPFSQVA--- 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 564 EVVQGSGAPA------ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGP 637
Cdd:PHA03379 643 DVMRAGGVPAmqpqyfDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVP 722
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 767904868 638 K----GSSSIQKEAVQGIAGS--LAPPLTKEETVQGPIAPATSLP 676
Cdd:PHA03379 723 ErwmfQGATLSQSVRPGVAQSqyFDLPLTQPINHGAPAAHFLHQP 767
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
296-678 |
1.02e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 296 IPASAHLPKNQDAPAACPDRDQGRAPDAracelwqvlGAPSSTELPLQTSQGQAS---VPSSPRLETH-VPSPgltHPAK 371
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPSAPSVPPQ---------GSPATSQPPNQTQSTAAPhtlIQQTPTLHPQrLPSP---HPPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 372 QPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQP-PAPSTTRRKDVPSPGGLSAPSSPRNKFVQ-N 449
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTpP 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 450 SENVPVLPFTQREVVKGPGA---PAASSPTRKEVVQGSSASAASSPtwkevvkgpgaPAASSPTQKEVVQGSSAPAALFP 526
Cdd:pfam03154 330 SQSQLQSQQPPREQPLPPAPlsmPHIKPPPTTPIPQLPNPQSHKHP-----------PHLSGPSPFQMNSNLPPPPALKP 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 527 TWKEVVKGPgaPDASFPTWKEVVKGPGAPaaSSPTQKEVV-QGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPca 605
Cdd:pfam03154 399 LSSLSTHHP--PSAHPPPLQLMPQSQQLP--PPPAQPPVLtQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGP-- 472
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767904868 606 PAASSPtqkevvqgSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQ 678
Cdd:pfam03154 473 PPITPP--------SGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPP 537
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
551-672 |
2.06e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.78 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 551 GPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKS 630
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 767904868 631 TEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPA 672
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
386-625 |
2.16e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.94 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 386 LVLPPKKKDGPVDPPAATVLPMVRsehVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQnsenvpvlpftqrevvk 465
Cdd:PRK12323 361 LAFRPGQSGGGAGPATAAAAPVAQ---PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA----------------- 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 466 gpGAPAASSPTRKEVvqgssasaasSPTWKEVVKGPGAPAASSPTQKEV-----------VQGSSAPAALFPTWKEVVKG 534
Cdd:PRK12323 421 --AAPARRSPAPEAL----------AAARQASARGPGGAPAPAPAPAAApaaaarpaaagPRPVAAAAAAAPARAAPAAA 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 535 PGAPDASFPTWKEVvkgPGAPAASSPTQKEvvqGSGAPAALSTTPKEvvkGPGAPAASSPTQKEVVKGPCAPAASSPTQK 614
Cdd:PRK12323 489 PAPADDDPPPWEEL---PPEFASPAPAQPD---AAPAGWVAESIPDP---ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
|
250
....*....|.
gi 767904868 615 EVVQGSGAPAA 625
Cdd:PRK12323 560 VVAPRPPRASA 570
|
|
| DUF959 |
pfam06121 |
Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' ... |
498-612 |
2.43e-03 |
|
Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' isoform of Collagen A.
Pssm-ID: 399255 [Multi-domain] Cd Length: 192 Bit Score: 40.97 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 498 VKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPdasfPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAAL-- 575
Cdd:pfam06121 41 VQPAAAPATHVAPQDDPAEQATAAASPELPLEELEAAPGRA----PGAPISAAAPAALAARPDMREENVAGVGAKILNia 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767904868 576 -----------STTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPT 612
Cdd:pfam06121 117 qgiqsfiqlwnDAAPTESPAGAGTLAASAPTDPLALAEPSGPAAESGT 164
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
466-632 |
2.44e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.53 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 466 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFP------TWKEVVKGPGAPD 539
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPaapappATADRGDDAADGD 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 540 ASFPTwKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEV-VQ 618
Cdd:PRK07003 447 APVPA-KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAA 525
|
170
....*....|....
gi 767904868 619 GSGAPAALSPKSTE 632
Cdd:PRK07003 526 APPAPEARPPTPAA 539
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
566-773 |
2.66e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.53 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 566 VQGSGAPAALSttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQK 645
Cdd:PRK07003 362 VTGGGAPGGGV--PARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 646 EAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEvvqdpdalPAPSSSVDRVSPSPGGTPAP 725
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE--------PAPRAAAPSAATPAAVPDAR 511
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 767904868 726 VPTGAEASTESQLVSDPTEgKTCTETSREEDEVALAADLEIFLDTLRS 773
Cdd:PRK07003 512 APAAASREDAPAAAAPPAP-EARPPTPAAAAPAARAGGAAAALDVLRN 558
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
396-737 |
2.71e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 42.25 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 396 PVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 475
Cdd:pfam17823 115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 476 TRKEVVQGSSASAASSPTWKEVVkGPGAPAASSPTQKevvQGSSAPAalfptwkevvkgPGAPDASFPTWKEVVKGPGAP 555
Cdd:pfam17823 195 PTTAASSAPATLTPARGISTAAT-ATGHPAAGTALAA---VGNSSPA------------AGTVTAAVGTVTPAALATLAA 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 556 AASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAAsspTQKEVVQGSGAPAALSPKSTEVVQ 635
Cdd:pfam17823 259 AAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVS---TDQPVHNTAGEPTPSPSNTTLEPN 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 636 GPKGSSSIQKEAVqgiagSLAPPLTKEETVQG-PIAPATSLPKQDKGVQDSEGSPISSlTQKevVQDPDALPAP------ 708
Cdd:pfam17823 336 TPKSVASTNLAVV-----TTTKAQAKEPSASPvPVLHTSMIPEVEATSPTTQPSPLLP-TQG--AAGPGILLAPeqvate 407
|
330 340 350
....*....|....*....|....*....|...
gi 767904868 709 -SSSVDRVSPSP---GGTPAPVPTGAEASTESQ 737
Cdd:pfam17823 408 aTAGTASAGPTPrssGDPKTLAMASCQLSTQGQ 440
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
526-626 |
3.08e-03 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 42.57 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 526 PTWKEV----VKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVk 601
Cdd:PRK12270 27 PSWREFfadyGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAA- 105
|
90 100
....*....|....*....|....*
gi 767904868 602 gpcAPAASSPTQKEVVQGSGAPAAL 626
Cdd:PRK12270 106 ---AAPAAAAVEDEVTPLRGAAAAV 127
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
498-737 |
5.19e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 41.76 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 498 VKGPGAPAASSPTQkeVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALST 577
Cdd:PRK07003 362 VTGGGAPGGGVPAR--VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 578 TPKEVVKGPGAPAASSPTQKEVVKGPCA--PAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIA--G 653
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDaqPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsrE 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904868 654 SLAPPLTKEETVQGPIAPATSLPKQDKG-------VQDSEGSPISSltqkEVVQDPDALPAPSSSVDRVSPSPGGTPA-P 725
Cdd:PRK07003 520 DAPAAAAPPAPEARPPTPAAAAPAARAGgaaaaldVLRNAGMRVSS----DRGARAAAAAKPAAAPAAAPKPAAPRVAvQ 595
|
250
....*....|...
gi 767904868 726 VPT-GAEASTESQ 737
Cdd:PRK07003 596 VPTpRARAATGDA 608
|
|
| |
