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Conserved domains on  [gi|767966401|ref|XP_011518622|]
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DENN domain-containing protein 2B isoform X4 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655163)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  11563850|21330364
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN super family cl11519
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 841-958 8.24e-39

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


The actual alignment was detected with superfamily member pfam02141:

Pssm-ID: 472208  Cd Length: 186  Bit Score: 142.71  E-value: 8.24e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401  841 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 917
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767966401  918 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSH 958
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLAR 120
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 727-814 4.51e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 97.02  E-value: 4.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401   727 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 803
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 767966401   804 SRRFGYCRRLL 814
Cdd:smart00800  79 SRRYGFCLRFY 89
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 841-958 8.24e-39

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 142.71  E-value: 8.24e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401  841 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 917
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767966401  918 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSH 958
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLAR 120
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 842-957 1.53e-36

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 136.17  E-value: 1.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401   842 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 921
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767966401   922 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLS 957
Cdd:smart00799  78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLS 115
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 727-814 4.51e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 97.02  E-value: 4.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401   727 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 803
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 767966401   804 SRRFGYCRRLL 814
Cdd:smart00800  79 SRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 746-812 2.02e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.40  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966401  746 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 812
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 841-958 8.24e-39

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 142.71  E-value: 8.24e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401  841 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 917
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767966401  918 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSH 958
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLAR 120
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 842-957 1.53e-36

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 136.17  E-value: 1.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401   842 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 921
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767966401   922 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLS 957
Cdd:smart00799  78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLS 115
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 727-814 4.51e-24

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 97.02  E-value: 4.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966401   727 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 803
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 767966401   804 SRRFGYCRRLL 814
Cdd:smart00800  79 SRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 746-812 2.02e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 68.40  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966401  746 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 812
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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