|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
1031-1260 |
1.77e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
:
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.77e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1031 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1107
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1108 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1181
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1182 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1258
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 767957151 1259 RN 1260
Cdd:smart00147 241 RV 242
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
883-1024 |
4.82e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
:
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 883 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 962
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957151 963 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 1024
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
236-494 |
1.75e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 236 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 315
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 316 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 389
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 390 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 467
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 767957151 468 PLAPGQQTDTPPALPEKKRRSAASQTA 494
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03307 super family |
cl33723 |
transcriptional regulator ICP4; Provisional |
721-892 |
1.37e-03 |
|
transcriptional regulator ICP4; Provisional
The actual alignment was detected with superfamily member PHA03307:
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 721 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 800
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 801 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 866
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 767957151 867 DHNEIMSRLTLKQEG--DDGPDVRGGSG 892
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
1031-1260 |
1.77e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.77e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1031 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1107
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1108 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1181
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1182 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1258
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 767957151 1259 RN 1260
Cdd:smart00147 241 RV 242
|
|
| RasGEF |
cd00155 |
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
1031-1255 |
9.13e-85 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.
Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 276.06 E-value: 9.13e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1031 LHDFHSHEIAEQLTLLDAELFYKIEIPE---VLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1107
Cdd:cd00155 1 FLSLDPKELAEQLTLLDFELFRKIEPFEllgSLWSKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1108 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEV--EPPCIPYL 1180
Cdd:cd00155 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSklkklFEELEELVDPSRNFKNYRKLLKSVgpNPPCVPFL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957151 1181 GLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDF-SDHLAEEALWELSLK 1255
Cdd:cd00155 161 GVYLKDLTFLHEGNPDFLEGNlVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLlELILNEDELYELSLE 237
|
|
| RasGEF |
pfam00617 |
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
1038-1208 |
4.04e-71 |
|
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
Pssm-ID: 459872 Cd Length: 179 Bit Score: 235.18 E-value: 4.04e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1038 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 1115
Cdd:pfam00617 1 ELARQLTLIEFELFRKIKPRELLgsAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1116 RKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFV 1190
Cdd:pfam00617 81 RELNNFNSLMAILSGLNSSPISRLKktWELvskKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
|
170
....*....|....*....
gi 767957151 1191 HLGNPDYIDGK-VNFSKRW 1208
Cdd:pfam00617 161 EEGNPDFLEGGlINFEKRR 179
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
883-1024 |
4.82e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 883 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 962
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957151 963 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 1024
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| REM |
cd06224 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
891-1005 |
5.12e-17 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Pssm-ID: 100121 Cd Length: 122 Bit Score: 78.22 E-value: 5.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 891 SGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSP-------FADTFKKRVSKNTFFVLVRVVDE 963
Cdd:cd06224 1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndWDKKKSKPIRLRVLNVLRTWVEN 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 767957151 964 LCLV-ELTEEILKLLMELVFRLVCNGELSlaRVLRKNILDKVD 1005
Cdd:cd06224 81 YPYDfFDDEELLELLEEFLNRLVQEGALL--QELKKLLRKLLK 121
|
|
| RasGEF_N |
pfam00618 |
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
887-982 |
1.55e-11 |
|
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.
Pssm-ID: 459873 Cd Length: 104 Bit Score: 61.94 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 887 VRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKK-RVSKNTFFVLVRVVdelc 965
Cdd:pfam00618 2 VKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSyWISKKTLPIRIRVL---- 77
|
90
....*....|....*..
gi 767957151 966 lvelteEILKLLMELVF 982
Cdd:pfam00618 78 ------SVLRHWVENYF 88
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
236-494 |
1.75e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 236 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 315
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 316 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 389
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 390 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 467
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 767957151 468 PLAPGQQTDTPPALPEKKRRSAASQTA 494
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
721-892 |
1.37e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 721 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 800
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 801 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 866
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 767957151 867 DHNEIMSRLTLKQEG--DDGPDVRGGSG 892
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RasGEF |
smart00147 |
Guanine nucleotide exchange factor for Ras-like small GTPases; |
1031-1260 |
1.77e-86 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases;
Pssm-ID: 214539 Cd Length: 242 Bit Score: 281.06 E-value: 1.77e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1031 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE-QNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1107
Cdd:smart00147 1 LLLLDPKELAEQLTLLDFELFRKIDPSELLgsVWGKRsKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDRAELLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1108 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEVE-PPCIPYLG 1181
Cdd:smart00147 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLPSkykklFEELEELLSPERNYKNYREALSSCNlPPCIPFLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1182 LILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRND-DIINFFNDFSDHLAEEA-LWELSLKIKP 1258
Cdd:smart00147 161 VLLKDLTFIDEGNPDFLeNGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRsDIQSLLQQLLDHLDEEEeLYQLSLKIEP 240
|
..
gi 767957151 1259 RN 1260
Cdd:smart00147 241 RV 242
|
|
| RasGEF |
cd00155 |
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ... |
1031-1255 |
9.13e-85 |
|
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.
Pssm-ID: 238087 [Multi-domain] Cd Length: 237 Bit Score: 276.06 E-value: 9.13e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1031 LHDFHSHEIAEQLTLLDAELFYKIEIPE---VLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLK 1107
Cdd:cd00155 1 FLSLDPKELAEQLTLLDFELFRKIEPFEllgSLWSKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKRARLLSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1108 FIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG-----LAEYCTLIDSSSSFRAYRAALSEV--EPPCIPYL 1180
Cdd:cd00155 81 FIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLSSklkklFEELEELVDPSRNFKNYRKLLKSVgpNPPCVPFL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767957151 1181 GLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDF-SDHLAEEALWELSLK 1255
Cdd:cd00155 161 GVYLKDLTFLHEGNPDFLEGNlVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLlELILNEDELYELSLE 237
|
|
| RasGEF |
pfam00617 |
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases. |
1038-1208 |
4.04e-71 |
|
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
Pssm-ID: 459872 Cd Length: 179 Bit Score: 235.18 E-value: 4.04e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1038 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 1115
Cdd:pfam00617 1 ELARQLTLIEFELFRKIKPRELLgsAWSKKDKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKKFIKIAEHC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 1116 RKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFV 1190
Cdd:pfam00617 81 RELNNFNSLMAILSGLNSSPISRLKktWELvskKYKKTLEELEKLMSPSRNFKNYREALSSASPPCIPFLGLYLTDLTFI 160
|
170
....*....|....*....
gi 767957151 1191 HLGNPDYIDGK-VNFSKRW 1208
Cdd:pfam00617 161 EEGNPDFLEGGlINFEKRR 179
|
|
| RasGEFN |
smart00229 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ... |
883-1024 |
4.82e-29 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
Pssm-ID: 214571 Cd Length: 127 Bit Score: 112.81 E-value: 4.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 883 DGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKrvskntffvlvrvVD 962
Cdd:smart00229 1 DGGLIKGGTLEALIEHLTEAFDKADPSFVETFLLTYRSFITTQELLQLLLYRYNAIPPESWVEEK-------------VN 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767957151 963 ELCLVELTEEILKLLMELVFRlVCNGELSLARVLRkNILDKVDQKKLLRCATSSQPLAARGV 1024
Cdd:smart00229 68 PRRVKNRVLNILRTWVENYWE-DFEDDPKLISFLL-EFLELVDDEKYPGLVTSLLNLLRRLS 127
|
|
| REM |
cd06224 |
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ... |
891-1005 |
5.12e-17 |
|
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Pssm-ID: 100121 Cd Length: 122 Bit Score: 78.22 E-value: 5.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 891 SGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSP-------FADTFKKRVSKNTFFVLVRVVDE 963
Cdd:cd06224 1 TLEALIEHLTSTFDMPDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenleyndWDKKKSKPIRLRVLNVLRTWVEN 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 767957151 964 LCLV-ELTEEILKLLMELVFRLVCNGELSlaRVLRKNILDKVD 1005
Cdd:cd06224 81 YPYDfFDDEELLELLEEFLNRLVQEGALL--QELKKLLRKLLK 121
|
|
| RasGEF_N |
pfam00618 |
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ... |
887-982 |
1.55e-11 |
|
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.
Pssm-ID: 459873 Cd Length: 104 Bit Score: 61.94 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 887 VRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKK-RVSKNTFFVLVRVVdelc 965
Cdd:pfam00618 2 VKAGTLEKLVEYLTSTRIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSyWISKKTLPIRIRVL---- 77
|
90
....*....|....*..
gi 767957151 966 lvelteEILKLLMELVF 982
Cdd:pfam00618 78 ------SVLRHWVENYF 88
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
236-494 |
1.75e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 236 GRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTEllPDATDEEVAPPKPPLPGIRVVDNSPPPAlPPKK 315
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTVGSLTSLADPPP-PPPT 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 316 RQSAPSPTRVAVVAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQL------ 389
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-------APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAApaagpp 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 390 SSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQ--LPLGGHPQPDG 467
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPpsLPLGGSVAPGG 2860
|
250 260
....*....|....*....|....*..
gi 767957151 468 PLAPGQQTDTPPALPEKKRRSAASQTA 494
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
235-833 |
6.04e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 235 QGRPSPTSPVKPSSPA-----SKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATdeevaPPKPPLPGIRVVDNSPP- 308
Cdd:PHA03247 2566 RSVPPPRPAPRPSEPAvtsraRRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH-----APDPPPPSPSPAANEPDp 2640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 309 ----PALPPKKRQSAPSPTRVAV---VAPMSRATSGSSLPVGINRQdfdvdcyAQRRLSGGSHSYGGESPRLSPCSSIGK 381
Cdd:PHA03247 2641 hpppTVPPPERPRDDPAPGRVSRprrARRLGRAAQASSPPQRPRRR-------AARPTVGSLTSLADPPPPPPTPEPAPH 2713
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 382 LSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDlSNADQIPQQTAWNLSPLPESlgesgSPFLGPPFQLPlgg 461
Cdd:PHA03247 2714 ALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-PARPARPPTTAGPPAPAPPA-----APAAGPPRRLT--- 2784
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 462 hPQPDGPLAPGQqtdtpPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAIlpfqhG 541
Cdd:PHA03247 2785 -RPAVASLSESR-----ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL-----G 2853
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 542 GSSAPvefVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLledysEPQPSMFYQTPqnehiyqqknkllmevygfsdsf 621
Cdd:PHA03247 2854 GSVAP---GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV-----SRSTESFALPP----------------------- 2902
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 622 sgvDSVQELAPPPALPPKQRQLQASCAASSFSSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLSR--HGSLPVPSYKs 699
Cdd:PHA03247 2903 ---DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAlvPGRVAVPRFR- 2978
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 700 vfrsysqdfVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQEssfhgntvclpSETSF 779
Cdd:PHA03247 2979 ---------VPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDD-----------TEDSD 3038
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 767957151 780 TDSSENASEEAGEGEYVNlyssGQSSEELAPSRGEP--PAGKDGHPRDPSAVSGVP 833
Cdd:PHA03247 3039 ADSLFDSDSERSDLEALD----PLPPEPHDPFAHEPdpATPEAGARESPSSQFGPP 3090
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
238-546 |
1.10e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 238 PSPTSPVKPSSPASKPdGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQ 317
Cdd:PHA03307 73 PGPGTEAPANESRSTP-TWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAAS 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 318 SAP-------------SPTRVAVVAPMSRAT----SGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIG 380
Cdd:PHA03307 152 PPAagaspaavasdaaSSRQAALPLSSPEETarapSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADD 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 381 KLSKSDEQLSSLDRDSGQCSRNTScetldhydPDYEFLQQDLsnADQIPQQTAWNLSPLPESLGESGSPFLGPpfqlplG 460
Cdd:PHA03307 232 AGASSSDSSSSESSGCGWGPENEC--------PLPRPAPITL--PTRIWEASGWNGPSSRPGPASSSSSPRER------S 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 461 GHPQPDGPLAPGQQTdTPPALPEKKR--------RSAASQTADGSGCRVSYERHPSQyDNISGEDLQSTAPIPSVPYAPF 532
Cdd:PHA03307 296 PSPSPSSPGSGPAPS-SPRASSSSSSsresssssTSSSSESSRGAAVSPGPSPSRSP-SPSRPPPPADPSSPRKRPRPSR 373
|
330
....*....|....
gi 767957151 533 AAILPFQHGGSSAP 546
Cdd:PHA03307 374 APSSPAASAGRPTR 387
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
721-892 |
1.37e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 721 PPTSSSSPHFPPAHQSqssdlavptmAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYS 800
Cdd:PHA03307 108 PPGPSSPDPPPPTPPP----------ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 801 SGQSSEELAPSRGEPPAGK--------DGHPRDPSAVSGV------PGKDSRDGSERAPKSPDALESAQSEEEVDELSLI 866
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPStppaaaspRPPRRSSPISASAsspapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
170 180
....*....|....*....|....*...
gi 767957151 867 DHNEIMSRLTLKQEG--DDGPDVRGGSG 892
Cdd:PHA03307 258 PRPAPITLPTRIWEAsgWNGPSSRPGPA 285
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
693-893 |
6.25e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.92 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 693 PVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQESSFHGNTVC 772
Cdd:PHA03307 130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 773 LPSETSFTDSSENASEEAGEGEYVNLYSSGQSSEEL-------------------APSRGEPPAGKDGHPRDPSAVSGVP 833
Cdd:PHA03307 210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpapitLPTRIWEASGWNGPSSRPGPASSSS 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957151 834 GkDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKqEGDDGPDVRGGSGD 893
Cdd:PHA03307 290 S-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSS-ESSRGAAVSPGPSP 347
|
|
| |
