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Conserved domains on  [gi|767920651|ref|XP_011510493|]
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nuclear body protein SP140-like protein isoform X12 [Homo sapiens]

Protein Classification

HSR and SAND domain-containing protein( domain architecture ID 10504693)

HSR and SAND domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 50-147 1.72e-64

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


:

Pssm-ID: 460835  Cd Length: 99  Bit Score: 200.07  E-value: 1.72e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920651   50 YDTVFKHFKRHKLEISNAIKKTFPFLEGLRDRELITNKMFEDSEDSCRNLVPVQRVVYNVLSELEKTFNLSVLEALFSEV 129
Cdd:pfam03172   2 EEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSDV 81

                          90
                  ....*....|....*...
gi 767920651  130 NMQEYPDLIHIYKSFKNA 147
Cdd:pfam03172  82 NLKEYPDLIEILKSFPNV 99
SAND super family cl02536
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 314-351 1.14e-07

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


The actual alignment was detected with superfamily member pfam01342:

Pssm-ID: 470606  Cd Length: 76  Bit Score: 48.73  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767920651  314 DFQAPLLPVTCGGVKGILHKEKLEQEPSADS----GLVSTPR 351
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCiqneDSWLTPK 42
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 50-147 1.72e-64

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 200.07  E-value: 1.72e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920651   50 YDTVFKHFKRHKLEISNAIKKTFPFLEGLRDRELITNKMFEDSEDSCRNLVPVQRVVYNVLSELEKTFNLSVLEALFSEV 129
Cdd:pfam03172   2 EEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSDV 81

                          90
                  ....*....|....*...
gi 767920651  130 NMQEYPDLIHIYKSFKNA 147
Cdd:pfam03172  82 NLKEYPDLIEILKSFPNV 99
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 314-351 1.14e-07

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 48.73  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767920651  314 DFQAPLLPVTCGGVKGILHKEKLEQEPSADS----GLVSTPR 351
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCiqneDSWLTPK 42
SAND smart00258
SAND domain;
318-338 3.75e-04

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 38.48  E-value: 3.75e-04
                           10        20
                   ....*....|....*....|.
gi 767920651   318 PLLPVTCGGVKGILHKEKLEQ 338
Cdd:smart00258   1 SELPVTCGTVKGILYKKKFKC 21
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 50-147 1.72e-64

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 200.07  E-value: 1.72e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767920651   50 YDTVFKHFKRHKLEISNAIKKTFPFLEGLRDRELITNKMFEDSEDSCRNLVPVQRVVYNVLSELEKTFNLSVLEALFSEV 129
Cdd:pfam03172   2 EEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSDV 81

                          90
                  ....*....|....*...
gi 767920651  130 NMQEYPDLIHIYKSFKNA 147
Cdd:pfam03172  82 NLKEYPDLIEILKSFPNV 99
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 314-351 1.14e-07

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 48.73  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767920651  314 DFQAPLLPVTCGGVKGILHKEKLEQEPSADS----GLVSTPR 351
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCiqneDSWLTPK 42
SAND smart00258
SAND domain;
318-338 3.75e-04

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 38.48  E-value: 3.75e-04
                           10        20
                   ....*....|....*....|.
gi 767920651   318 PLLPVTCGGVKGILHKEKLEQ 338
Cdd:smart00258   1 SELPVTCGTVKGILYKKKFKC 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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