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Conserved domains on  [gi|759000673|ref|XP_011395301|]
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superoxide dismutase, variant [Neurospora crassa OR74A]

Protein Classification

superoxide dismutase( domain architecture ID 11427369)

superoxide dismutase eliminates superoxide radicals by catalyzing their conversion into hydrogen peroxide and oxygen

EC:  1.15.1.1
Gene Ontology:  GO:0046872|GO:0004784

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
30-228 2.32e-91

Superoxide dismutase [Inorganic ion transport and metabolism];


:

Pssm-ID: 223678  Cd Length: 204  Bit Score: 266.82  E-value: 2.32e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  30 RGKATLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGD----FTKAASVAPLLNFHGGGHLNH 105
Cdd:COG0605    1 RMAYELPELPYAYDALEPHISAETMELHHDKHHQTYVNNLNAALEGLTEELEDLSleeiIKKLAGLPAALFNNAGGHWNH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 106 TLFWENLAPASreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALITRANQD-PVTGN 184
Cdd:COG0605   81 SLFWENLSPGG--GGGKPTGELAAAINKDFGSFDKFKEEFTAAAASVFGSGWAWLVYDP--DGKLEIVSTYNQDtPLMWG 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 759000673 185 YVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:COG0605  157 SVPLLGLDVWEHAYYLDYGNRRPDYVEAFWNVVNWDEVEERFEA 200
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
30-228 2.32e-91

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 223678  Cd Length: 204  Bit Score: 266.82  E-value: 2.32e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  30 RGKATLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGD----FTKAASVAPLLNFHGGGHLNH 105
Cdd:COG0605    1 RMAYELPELPYAYDALEPHISAETMELHHDKHHQTYVNNLNAALEGLTEELEDLSleeiIKKLAGLPAALFNNAGGHWNH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 106 TLFWENLAPASreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALITRANQD-PVTGN 184
Cdd:COG0605   81 SLFWENLSPGG--GGGKPTGELAAAINKDFGSFDKFKEEFTAAAASVFGSGWAWLVYDP--DGKLEIVSTYNQDtPLMWG 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 759000673 185 YVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:COG0605  157 SVPLLGLDVWEHAYYLDYGNRRPDYVEAFWNVVNWDEVEERFEA 200
PLN02471 PLN02471
superoxide dismutase [Mn]
34-227 9.66e-81

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 240.97  E-value: 9.66e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  34 TLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGDFTKAASVAPLLNFHGGGHLNHTLFWENLA 113
Cdd:PLN02471  32 TLPDLPYDYGALEPAISGEIMQLHHQKHHQTYVTNYNKALEQLDQAVEKGDASAVVKLQSAIKFNGGGHVNHSIFWKNLA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 114 PASREGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKAANgKLALITRANQDPVT---GNYVPLLG 190
Cdd:PLN02471 112 PVSEGGGEPPHGSLGWAIDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKELK-KLVVETTANQDPLVtkgPSLVPLLG 190
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 759000673 191 IDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFE 227
Cdd:PLN02471 191 IDVWEHAYYLQYKNVRPDYLKNIWKVMNWKYASEVYE 227
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
123-225 1.09e-56

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 426976  Cd Length: 102  Bit Score: 175.31  E-value: 1.09e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  123 PDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALITRANQD-PVTGNYVPLLGIDAWEHAYYLQ 201
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDP--DGKLEIVTTPNQDnPLTDGLTPLLGLDVWEHAYYLD 78
                          90       100
                  ....*....|....*....|....
gi 759000673  202 YENRKAEYFEAIWNVINWKTVAKR 225
Cdd:pfam02777  79 YQNRRADYVKAFWNVVNWDEVEKR 102
 
Name Accession Description Interval E-value
SodA COG0605
Superoxide dismutase [Inorganic ion transport and metabolism];
30-228 2.32e-91

Superoxide dismutase [Inorganic ion transport and metabolism];


Pssm-ID: 223678  Cd Length: 204  Bit Score: 266.82  E-value: 2.32e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  30 RGKATLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGD----FTKAASVAPLLNFHGGGHLNH 105
Cdd:COG0605    1 RMAYELPELPYAYDALEPHISAETMELHHDKHHQTYVNNLNAALEGLTEELEDLSleeiIKKLAGLPAALFNNAGGHWNH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 106 TLFWENLAPASreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALITRANQD-PVTGN 184
Cdd:COG0605   81 SLFWENLSPGG--GGGKPTGELAAAINKDFGSFDKFKEEFTAAAASVFGSGWAWLVYDP--DGKLEIVSTYNQDtPLMWG 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 759000673 185 YVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:COG0605  157 SVPLLGLDVWEHAYYLDYGNRRPDYVEAFWNVVNWDEVEERFEA 200
PLN02471 PLN02471
superoxide dismutase [Mn]
34-227 9.66e-81

superoxide dismutase [Mn]


Pssm-ID: 215262  Cd Length: 231  Bit Score: 240.97  E-value: 9.66e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  34 TLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGDFTKAASVAPLLNFHGGGHLNHTLFWENLA 113
Cdd:PLN02471  32 TLPDLPYDYGALEPAISGEIMQLHHQKHHQTYVTNYNKALEQLDQAVEKGDASAVVKLQSAIKFNGGGHVNHSIFWKNLA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 114 PASREGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKAANgKLALITRANQDPVT---GNYVPLLG 190
Cdd:PLN02471 112 PVSEGGGEPPHGSLGWAIDEHFGSLEALVKKMSAEGAAVQGSGWVWLGLDKELK-KLVVETTANQDPLVtkgPSLVPLLG 190
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 759000673 191 IDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFE 227
Cdd:PLN02471 191 IDVWEHAYYLQYKNVRPDYLKNIWKVMNWKYASEVYE 227
Sod_Fe_C pfam02777
Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze ...
123-225 1.09e-56

Iron/manganese superoxide dismutases, C-terminal domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.


Pssm-ID: 426976  Cd Length: 102  Bit Score: 175.31  E-value: 1.09e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  123 PDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALITRANQD-PVTGNYVPLLGIDAWEHAYYLQ 201
Cdd:pfam02777   1 PTGALAEAIEKDFGSFDAFKEEFNAAAAGVFGSGWAWLVYDP--DGKLEIVTTPNQDnPLTDGLTPLLGLDVWEHAYYLD 78
                          90       100
                  ....*....|....*....|....
gi 759000673  202 YENRKAEYFEAIWNVINWKTVAKR 225
Cdd:pfam02777  79 YQNRRADYVKAFWNVVNWDEVEKR 102
PRK10925 PRK10925
superoxide dismutase [Mn];
34-228 3.49e-55

superoxide dismutase [Mn];


Pssm-ID: 182843  Cd Length: 206  Bit Score: 175.11  E-value: 3.49e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  34 TLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKG--DFTKAASVAP-----LLNFHGGGHLNHT 106
Cdd:PRK10925   4 TLPSLPYAYDALEPHFDKQTMEIHHTKHHQTYVNNANAALESLPEFANLPveELITKLDQLPadkktVLRNNAGGHANHS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 107 LFWENLapasrEGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDkaaNGKLALITRANQD-PVTGNY 185
Cdd:PRK10925  84 LFWKGL-----KKGTTLQGDLKAAIERDFGSVDNFKAEFEKAAATRFGSGWAWLVLK---GDKLAVVSTANQDsPLMGEA 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 759000673 186 V------PLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:PRK10925 156 IsgasgfPILGLDVWEHAYYLKFQNRRPDYIKEFWNVVNWDEAAARFAA 204
PRK10543 PRK10543
superoxide dismutase [Fe];
35-228 6.41e-46

superoxide dismutase [Fe];


Pssm-ID: 182534  Cd Length: 193  Bit Score: 151.26  E-value: 6.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  35 LPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNS----------ALTTIAEAESKGDFTKAASVapllnfhggghLN 104
Cdd:PRK10543   5 LPALPYAKDALAPHISAETLEYHYGKHHQTYVTNLNNlikgtafegkSLEEIVRSSEGGVFNNAAQV-----------WN 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 105 HTLFWENLAPasrEGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDkaANGKLALITRANQ-DPVTG 183
Cdd:PRK10543  74 HTFYWNCLAP---NAGGEPTGKVAEAIAASFGSFADFKAQFTDAAIKNFGSGWTWLVKN--ADGKLAIVSTSNAgTPLTT 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 759000673 184 NYVPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:PRK10543 149 DATPLLTVDVWEHAYYIDYRNARPGYLEHFWALVNWEFVAKNLAA 193
PLN02685 PLN02685
iron superoxide dismutase
40-228 1.84e-41

iron superoxide dismutase


Pssm-ID: 215369  Cd Length: 299  Bit Score: 142.83  E-value: 1.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  40 YDYGALEPYISSKIMELHHSKHHQTYVNGLNSALT-----------TIAEAESKGD----FTKAASVapllnfhggghLN 104
Cdd:PLN02685  54 YPLDALEPHMSRETLEYHWGKHHRAYVDNLNKQIVgteldgmsledVVLITYNKGDmlpaFNNAAQA-----------WN 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 105 HTLFWENLAPAsreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLA--------------KDKAANGKL 170
Cdd:PLN02685 123 HEFFWESMKPG---GGGKPSGELLQLIERDFGSFERFVEEFKSAAATQFGSGWAWLAykanrldvgnavnpCPSEEDKKL 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 171 ALITRANQ-DPVTGNYVPLLGIDAWEHAYYLQYENRKAEYFEAIWN-VINWKTVAKRFEA 228
Cdd:PLN02685 200 VVVKSPNAvNPLVWDYSPLLTIDVWEHAYYLDFQNRRPDYISTFMEkLVSWEAVSARLES 259
PTZ00078 PTZ00078
Superoxide dismutase [Fe]; Provisional
36-228 3.12e-36

Superoxide dismutase [Fe]; Provisional


Pssm-ID: 185432  Cd Length: 193  Bit Score: 126.06  E-value: 3.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  36 PDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNS----------ALTTIAEAESKGDFTKAASVapllnfhggghLNH 105
Cdd:PTZ00078   1 PKLPYGLKELSPHLSEETLKFHYSKHHAGYVNKLNGlikgtplenkTLEELIKEYSGAVFNNAAQI-----------WNH 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 106 TLFWENLAPasrEGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKDKaaNGKLALI-TRANQDPVTGN 184
Cdd:PTZ00078  70 NFYWLSMGP---NGGGEPTGEIKEKIDEKFGSFDNFKNEFSNVLSGHFGSGWGWLVLKN--DGKLEIVqTHDAGNPIKDN 144
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 759000673 185 Y-VPLLGIDAWEHAYYLQYENRKAEYFEAIWNVINWKTVAKRFEA 228
Cdd:PTZ00078 145 TgKPLLTCDIWEHAYYIDYRNDRASYVNSWWNKVNWDFANKNLKK 189
PLN02622 PLN02622
iron superoxide dismutase
40-225 2.07e-35

iron superoxide dismutase


Pssm-ID: 166263 [Multi-domain]  Cd Length: 261  Bit Score: 125.90  E-value: 2.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  40 YDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTT--IAEAESKGDFTKAA--SVAPLLNFHGGGHL-NHTLFWENLAP 114
Cdd:PLN02622  55 YPLDALEPYMSRRTLEVHWGEHHRGYVEGLNKQLAKddILYGYTMDELVKVTynNGNPLPEFNNAAQVwNHDFFWESMQP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 115 AsreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAKdKAANGKLALITRANQ-DPVTGNYVPLLGIDA 193
Cdd:PLN02622 135 G---GGDMPELGVLEQIEKDFGSFTNFREKFTEAALTLFGSGWVWLVL-KREERRLEVVKTSNAiNPLVWDDIPIICLDV 210
                        170       180       190
                 ....*....|....*....|....*....|...
gi 759000673 194 WEHAYYLQYENRKAEYFEAIWN-VINWKTVAKR 225
Cdd:PLN02622 211 WEHAYYLDYKNDRGKYVNAFMNhLVSWNAAMAR 243
Sod_Fe_N pfam00081
Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) ...
34-113 3.39e-33

Iron/manganese superoxide dismutases, alpha-hairpin domain; superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin. A small fragment of YTRE_LEPBI matches well - sequencing error?


Pssm-ID: 425457  Cd Length: 82  Bit Score: 114.71  E-value: 3.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673   34 TLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLNSALTTIAEAESKGDFTKAASVAPLLNFHGGGHLNHTLFWENLA 113
Cdd:pfam00081   3 ELPDLPYAYDALEPHISKETMEIHHTKHHQTYVNNLNAALEGLEEARKPLEELIIKALLGGLFNNGGGHWNHSLFWKNLS 82
PLN02184 PLN02184
superoxide dismutase [Fe]
25-228 6.86e-33

superoxide dismutase [Fe]


Pssm-ID: 177838  Cd Length: 212  Bit Score: 118.31  E-value: 6.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673  25 AATFVRGKATLPDLQYDYGALEPYISSKIMELHHSKHHQTYVNGLN-SALTTIAEAESKGDFTKA----ASVAPLLNfHG 99
Cdd:PLN02184   3 ASSAVTANYVLKPPPFALDALEPHMSKQTLEFHWGKHHRAYVDNLKkQVLGTELEGKPLEHIIHStynnGDLLPAFN-NA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 759000673 100 GGHLNHTLFWENLAPAsreGGGSPDGALGKAITTEFGSFESFVKQMNAALAGIQGSGWAWLAkdkAANGKLALITRANQ- 178
Cdd:PLN02184  82 AQAWNHEFFWESMKPG---GGGKPSGELLALLERDFTSYEKFYEEFNAAAATQFGAGWAWLA---YSNEKLKVVKTPNAv 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 759000673 179 DPVTGNYVPLLGIDAWEHAYYLQYENRKAEYFEA-IWNVINWKTVAKRFEA 228
Cdd:PLN02184 156 NPLVLGSFPLLTIDVWEHAYYLDFQNRRPDYIKTfMTNLVSWEAVSARLEA 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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