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Conserved domains on  [gi|755554055|ref|XP_011244317|]
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mitogen-activated protein kinase kinase kinase 13 isoform X1 [Mus musculus]

Protein Classification

mitogen-activated protein kinase kinase kinase( domain architecture ID 10197250)

mitogen-activated protein kinase kinase kinase (MAP3K) catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; MAP3Ks phosphorylate and activate MAP2Ks, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
173-409 0e+00

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 540.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP 252
Cdd:cd14059    1 LGSGAQGAVFLGKFRGEEVAVKKVRDEKETDIKHLRKLNHPNIIKFKGVCTQAPCYCILMEYCPYGQLYEVLRAGREITP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 253 RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 332
Cdd:cd14059   81 SLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSFAGTVAWMAPEVIRNEPCSEK 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 333 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIA 409
Cdd:cd14059  161 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLQLPVPSTCPDGFKLLMKQCWNSKPRNRPSFRQILMHLDIA 237
 
Name Accession Description Interval E-value
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
173-409 0e+00

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 540.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP 252
Cdd:cd14059    1 LGSGAQGAVFLGKFRGEEVAVKKVRDEKETDIKHLRKLNHPNIIKFKGVCTQAPCYCILMEYCPYGQLYEVLRAGREITP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 253 RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 332
Cdd:cd14059   81 SLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSFAGTVAWMAPEVIRNEPCSEK 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 333 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIA 409
Cdd:cd14059  161 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLQLPVPSTCPDGFKLLMKQCWNSKPRNRPSFRQILMHLDIA 237
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
167-401 2.58e-78

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 255.55  E-value: 2.58e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   167 ISELQWLGSGAQGAVFLGKFRA------EEVAIKKVREQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:smart00221   1 LTLGKKLGEGAFGEVYKGTLKGkgdgkeVEVAVKTLKEDASEQqieeflreARIMRKLDHPNIVKLLGVCTEEEPLMIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   233 EYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:smart00221  81 EYMPGGDLLDYLRKnrPKELSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   311 SFAG--TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPSTCPDGFKILMKQ 387
Cdd:smart00221 161 VKGGklPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTlGEEPYPGMSNAEVLEYLKKGYR-LPKPPNCPPELYKLMLQ 239
                          250
                   ....*....|....
gi 755554055   388 TWQSKPRNRPSFRQ 401
Cdd:smart00221 240 CWAEDPEDRPTFSE 253
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
173-406 1.91e-73

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 242.40  E-value: 1.91e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  173 LGSGAQGAVFLGKFRAE------EVAIKKVREQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:pfam07714   7 LGEGAFGEVYKGTLKGEgentkiKVAVKTLKEGADEEeredfleeASIMKKLDHPNIVKLLGVCTQGEPLYIVTEYMPGG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  239 QLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST-KMSFAGT- 315
Cdd:pfam07714  87 DLLDFLRKhKRKLTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYyRKRGGGKl 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  316 -VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:pfam07714 167 pIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTlGEQPYPGMSNEEVLEFL-EDGYRLPQPENCPDELYDLMKQCWAYDP 245
                         250
                  ....*....|...
gi 755554055  394 RNRPSFRQTLMHL 406
Cdd:pfam07714 246 EDRPTFSELVEDL 258
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
173-364 1.65e-45

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 171.35  E-value: 1.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:COG0515   15 LGRGGMGVVYLARDLRlgRPVALKVLRPELAADpearerfrreARALARLNHPNIVRVYDVGEEDGRPYLVMEYVEGESL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS--FAGTVAW 318
Cdd:COG0515   95 ADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTgtVVGTPGY 174
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV 364
Cdd:COG0515  175 MAPEQARGEPVDPRSDVYSLGVTLYELLTGRPPFDGDSPAELLRAH 220
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
189-352 1.62e-32

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 133.77  E-value: 1.62e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 189 EEVAIKKVREQNETD---IKHLR-------KLKHPNIIAFKGVCTQAPCYCIIMEYCAhGQ-LYEVLRAGRKITPRLLVD 257
Cdd:NF033483  33 RDVAVKVLRPDLARDpefVARFRreaqsaaSLSHPNIVSVYDVGEDGGIPYIVMEYVD-GRtLKDYIREHGPLSPEEAVE 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA--GTVAWMAPEVIRNEPVSEKVDI 335
Cdd:NF033483 112 IMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARALSSTTMTQTNSvlGTVHYLSPEQARGGTVDARSDI 191
                        170
                 ....*....|....*..
gi 755554055 336 WSFGVVLWELLTGEIPY 352
Cdd:NF033483 192 YSLGIVLYEMLTGRPPF 208
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
163-418 4.90e-24

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 104.91  E-value: 4.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFR--AEEVAIK--------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:PLN00034  72 SLSELERVNRIGSGAGGTVYKVIHRptGRLYALKviygnhedTVRRQICREIEILRDVNHPNVVKCHDMFDHNGEIQVLL 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLyevlrAGRKIT-PRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM- 310
Cdd:PLN00034 152 EFMDGGSL-----EGTHIAdEQFLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCn 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKV-----DIWSFGVVLWELLTGEIPY---KDVDSSAIIWGVGSNSLHLPVPSTCPDgFK 382
Cdd:PLN00034 227 SSVGTIAYMSPERINTDLNHGAYdgyagDIWSLGVSILEFYLGRFPFgvgRQGDWASLMCAICMSQPPEAPATASRE-FR 305
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 383 ILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQ 418
Cdd:PLN00034 306 HFISCCLQREPAKRWSAMQLLQHPFILRAQPGQGQG 341
 
Name Accession Description Interval E-value
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
173-409 0e+00

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 540.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP 252
Cdd:cd14059    1 LGSGAQGAVFLGKFRGEEVAVKKVRDEKETDIKHLRKLNHPNIIKFKGVCTQAPCYCILMEYCPYGQLYEVLRAGREITP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 253 RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 332
Cdd:cd14059   81 SLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSFAGTVAWMAPEVIRNEPCSEK 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 333 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIA 409
Cdd:cd14059  161 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLQLPVPSTCPDGFKLLMKQCWNSKPRNRPSFRQILMHLDIA 237
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
173-406 4.97e-110

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 339.51  E-value: 4.97e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd13999    1 IGSGSFGEVYKGKWRGTDVAIKKLKVEDDNDellkefrreVSILSKLRHPNIVQFIGACLSPPPLCIVTEYMPGGSLYDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMAP 321
Cdd:cd13999   81 LHKKKiPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKNSTTEKMtGVVGTPRWMAP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 322 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd13999  161 EVLRGEPYTEKADVYSFGIVLWELLTGEVPFKELSPIQIAAAVVQKGLRPPIPPDCPPELSKLIKRCWNEDPEKRPSFSE 240

                 ....*
gi 755554055 402 TLMHL 406
Cdd:cd13999  241 IVKRL 245
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
173-407 1.89e-92

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 293.53  E-value: 1.89e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDI----KHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14061    2 IGVGGFGKVYRGIWRGEEVAVKAARQDPDEDIsvtlENVRQearlfwmLRHPNIIALRGVCLQPPNLCLVMEYARGGALN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLrAGRKITPRLLVDWSTGIASGMNYLHLHK---IIHRDLKSPNVLV----------THTdaVKISDFGTSKELSdKST 308
Cdd:cd14061   82 RVL-AGRKIPPHVLVDWAIQIARGMNYLHNEApvpIIHRDLKSSNILIleaienedleNKT--LKITDFGLAREWH-KTT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQT 388
Cdd:cd14061  158 RMSAAGTYAWMAPEVIKSSTFSKASDVWSYGVLLWELLTGEVPYKGIDGLAVAYGVAVNKLTLPIPSTCPEPFAQLMKDC 237
                        250
                 ....*....|....*....
gi 755554055 389 WQSKPRNRPSFRQTLMHLD 407
Cdd:cd14061  238 WQPDPHDRPSFADILKQLE 256
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
173-407 1.74e-81

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 264.54  E-value: 1.74e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDI----KHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14148    2 IGVGGFGKVYKGLWRGEEVAVKAARQDPDEDIavtaENVRQearlfwmLQHPNIIALRGVCLNPPHLCLVMEYARGGALN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLrAGRKITPRLLVDWSTGIASGMNYLH---LHKIIHRDLKSPNVLVTH--------TDAVKISDFGTSKELSdKSTKM 310
Cdd:cd14148   82 RAL-AGKKVPPHVLVNWAVQIARGMNYLHneaIVPIIHRDLKSSNILILEpienddlsGKTLKITDFGLAREWH-KTTKM 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd14148  160 SAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWD 239
                        250
                 ....*....|....*..
gi 755554055 391 SKPRNRPSFRQTLMHLD 407
Cdd:cd14148  240 PDPHGRPDFGSILKRLE 256
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
167-401 2.58e-78

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 255.55  E-value: 2.58e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   167 ISELQWLGSGAQGAVFLGKFRA------EEVAIKKVREQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:smart00221   1 LTLGKKLGEGAFGEVYKGTLKGkgdgkeVEVAVKTLKEDASEQqieeflreARIMRKLDHPNIVKLLGVCTEEEPLMIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   233 EYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:smart00221  81 EYMPGGDLLDYLRKnrPKELSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   311 SFAG--TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPSTCPDGFKILMKQ 387
Cdd:smart00221 161 VKGGklPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTlGEEPYPGMSNAEVLEYLKKGYR-LPKPPNCPPELYKLMLQ 239
                          250
                   ....*....|....
gi 755554055   388 TWQSKPRNRPSFRQ 401
Cdd:smart00221 240 CWAEDPEDRPTFSE 253
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
167-401 4.77e-78

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 255.15  E-value: 4.77e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   167 ISELQWLGSGAQGAVFLGKFRA------EEVAIKKVR----EQNETD----IKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:smart00219   1 LTLGKKLGEGAFGEVYKGKLKGkggkkkVEVAVKTLKedasEQQIEEflreARIMRKLDHPNVVKLLGVCTEEEPLYIVM 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   233 EYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS 311
Cdd:smart00219  81 EYMEGGDLLSYLRKNRpKLSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYRK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   312 FAG--TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPSTCPDGFKILMKQT 388
Cdd:smart00219 161 RGGklPIRWMAPESLKEGKFTSKSDVWSFGVLLWEIFTlGEQPYPGMSNEEVLEYLKNGYR-LPQPPNCPPELYDLMLQC 239
                          250
                   ....*....|...
gi 755554055   389 WQSKPRNRPSFRQ 401
Cdd:smart00219 240 WAEDPEDRPTFSE 252
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
173-406 1.08e-76

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 251.88  E-value: 1.08e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14146    2 IGVGGFGKVYRATWKGQEVAVKAARQDPDEDIkataesvrqeaKLFSMLRHPNIIKLEGVCLEEPNLCLVMEFARGGTLN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVL---------RAGRKITPRLLVDWSTGIASGMNYLH---LHKIIHRDLKSPNVL----VTHTD----AVKISDFGTSK 301
Cdd:cd14146   82 RALaaanaapgpRRARRIPPHILVNWAVQIARGMLYLHeeaVVPILHRDLKSSNILllekIEHDDicnkTLKITDFGLAR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSdKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd14146  162 EWH-RTTKMSAAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPF 240
                        250       260
                 ....*....|....*....|....*
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd14146  241 AKLMKECWEQDPHIRPSFALILEQL 265
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
164-407 6.67e-76

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 249.56  E-value: 6.67e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI----KHLRK-------LKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd14147    2 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDIsvtaESVRQearlfamLAHPNIIALKAVCLEEPNLCLVM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLrAGRKITPRLLVDWSTGIASGMNYLH---LHKIIHRDLKSPNVLVTHT--------DAVKISDFGTSK 301
Cdd:cd14147   82 EYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHceaLVPVIHRDLKSNNILLLQPienddmehKTLKITDFGLAR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSdKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd14147  161 EWH-KTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPF 239
                        250       260
                 ....*....|....*....|....*.
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14147  240 AQLMADCWAQDPHRRPDFASILQQLE 265
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
161-406 1.04e-75

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 249.19  E-value: 1.04e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKLKHPNIIAFKGVCTQAPCYC 229
Cdd:cd14145    2 EIDFSELVLEEIIGIGGFGKVYRAIWIGDEVAVKAARHDPDEDIsqtienvrqeaKLFAMLKHPNIIALRGVCLKEPNLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLrAGRKITPRLLVDWSTGIASGMNYLHLHKI---IHRDLKSPNVLVTH--------TDAVKISDFG 298
Cdd:cd14145   82 LVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHCEAIvpvIHRDLKSSNILILEkvengdlsNKILKITDFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 TSKELSdKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 378
Cdd:cd14145  161 LAREWH-RTTKMSAAGTYAWMAPEVIRSSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLSLPIPSTCP 239
                        250       260
                 ....*....|....*....|....*...
gi 755554055 379 DGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd14145  240 EPFARLMEDCWNPDPHSRPPFTNILDQL 267
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
173-406 1.91e-73

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 242.40  E-value: 1.91e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  173 LGSGAQGAVFLGKFRAE------EVAIKKVREQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:pfam07714   7 LGEGAFGEVYKGTLKGEgentkiKVAVKTLKEGADEEeredfleeASIMKKLDHPNIVKLLGVCTQGEPLYIVTEYMPGG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  239 QLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST-KMSFAGT- 315
Cdd:pfam07714  87 DLLDFLRKhKRKLTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYyRKRGGGKl 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  316 -VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:pfam07714 167 pIKWMAPESLKDGKFTSKSDVWSFGVLLWEIFTlGEQPYPGMSNEEVLEFL-EDGYRLPQPENCPDELYDLMKQCWAYDP 245
                         250
                  ....*....|...
gi 755554055  394 RNRPSFRQTLMHL 406
Cdd:pfam07714 246 EDRPTFSELVEDL 258
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
173-405 2.03e-71

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 236.66  E-value: 2.03e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:smart00220   7 LGEGSFGKVYLARDKKtgKLVAIKVIKKKKIKKDRErilreikiLKKLKHPNIVRLYDVFEDEDKLYLVMEYCEGGDLFD 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 322
Cdd:smart00220  87 LLKKRGRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDPGEKLTTFVGTPEYMAPE 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055   323 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLHLPVPS-TCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:smart00220 167 VLLGKGYGKAVDIWSLGVILYELLTGKPPFPGDDQlLELFKKIGKPKPPFPPPEwDISPEAKDLIRKLLVKDPEKRLTAE 246

                   ....*
gi 755554055   401 QTLMH 405
Cdd:smart00220 247 EALQH 251
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
173-407 1.11e-66

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 224.34  E-value: 1.11e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-----EVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd00192    3 LGEGAFGEVYKGKLKGGdgktvDVAVKTLKEDASESERKdflkearvMKKLGHPNVVRLLGVCTEEEPLYLVMEYMEGGD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRK---------ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:cd00192   83 LLDFLRKSRPvfpspepstLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSRDIYDDDYYR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDGFKILMK 386
Cdd:cd00192  163 KKTGGklpIRWMAPESLKDGIFTSKSDVWSFGVLLWEIFTlGATPYPGLSNEEVLEYLRKGY-RLPKPENCPDELYELML 241
                        250       260
                 ....*....|....*....|.
gi 755554055 387 QTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd00192  242 SCWQLDPEDRPTFSELVERLE 262
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
174-407 4.45e-65

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 219.06  E-value: 4.45e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQGAVFLGKF--RAEEVAIKKVReQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR--K 249
Cdd:cd14060    2 GGGSFGSVYRAIWvsQDKEVAVKKLL-KIEKEAEILSVLSHRNIIQFYGAILEAPNYGIVTEYASYGSLFDYLNSNEseE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 250 ITPRLLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRN 326
Cdd:cd14060   81 MDMDQIMTWATDIAKGMHYLHMEapvKVIHRDLKSRNVVIAADGVLKICDFGASRFHSH-TTHMSLVGTFPWMAPEVIQS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 327 EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd14060  160 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERPTIPSSCPRSFAELMRRCWEADVKERPSFKQIIGIL 239

                 .
gi 755554055 407 D 407
Cdd:cd14060  240 E 240
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
173-405 1.42e-63

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 215.46  E-value: 1.42e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd06606    8 LGKGSFGSVYLALNLDtgELMAVKEVELSGDSEeelealereIRILSSLKHPNIVRYLGTERTENTLNIFLEYVPGGSLA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK---MSFAGTVAW 318
Cdd:cd06606   88 SLLKKFGKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAKRLAEIATGegtKSLRGTPYW 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS-AIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRP 397
Cdd:cd06606  168 MAPEVIRGEGYGRAADIWSLGCTVIEMATGKPPWSELGNPvAALFKIGSSGEPPPIPEHLSEEAKDFLRKCLQRDPKKRP 247

                 ....*...
gi 755554055 398 SFRQTLMH 405
Cdd:cd06606  248 TADELLQH 255
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
173-401 2.00e-56

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 195.35  E-value: 2.00e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKV-----REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRaG 247
Cdd:cd14058    1 VGRGSFGVVCKARWRNQIVAVKIIeseseKKAFEVEVRQLSRVDHPNIIKLYGACSNQKPVCLVMEYAEGGSLYNVLH-G 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 248 RKITPRL----LVDWSTGIASGMNYLHLHK---IIHRDLKSPNVLVT--HTDaVKISDFGTSkelSDKSTKMS-FAGTVA 317
Cdd:cd14058   80 KEPKPIYtaahAMSWALQCAKGVAYLHSMKpkaLIHRDLKPPNLLLTngGTV-LKICDFGTA---CDISTHMTnNKGSAA 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPRN 395
Cdd:cd14058  156 WMAPEVFEGSKYSEKCDVFSWGIILWEVITRRKPFDHIGGPAfrIMWAV-HNGERPPLIKNCPKPIESLMTRCWSKDPEK 234

                 ....*.
gi 755554055 396 RPSFRQ 401
Cdd:cd14058  235 RPSMKE 240
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
173-406 8.12e-55

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 189.40  E-value: 8.12e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd00180    1 LGKGSFGKVYKARDKEtgKKVAVKVIPKEKLKKLLEellreieiLKKLNHPNIVKLYDVFETENFLYLVMEYCEGGSLKD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAW 318
Cdd:cd00180   81 LLKEnKGPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGttpPYY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELltgeipykdvdssaiiwgvgsnslhlpvpstcpDGFKILMKQTWQSKPRNRPS 398
Cdd:cd00180  161 APPELLGGRYYGPKVDIWSLGVILYEL---------------------------------EELKDLIRRMLQYDPKKRPS 207

                 ....*...
gi 755554055 399 FRQTLMHL 406
Cdd:cd00180  208 AKELLEHL 215
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
164-405 3.08e-54

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 189.34  E-value: 3.08e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRA--EEVAIKKVREQNETD-------IKHLRKLKHPNIIAFKGvctqapCYC----- 229
Cdd:cd05122    2 FEILEKI---GKGGFGVVYKARHKKtgQIVAIKKINLESKEKkesilneIAILKKCKHPNIVKYYG------SYLkkdel 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 -IIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKS 307
Cdd:cd05122   73 wIVMEFCSGGSLKDLLKNtNKTLTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSAQLSDGK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL-HLPVPSTCPDGFKILMK 386
Cdd:cd05122  153 TRNTFVGTPYWMAPEVIQGKPYGFKADIWSLGITAIEMAEGKPPYSELPPMKALFLIATNGPpGLRNPKKWSKEFKDFLK 232
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd05122  233 KCLQKDPEKRPTAEQLLKH 251
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
160-406 1.55e-52

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 184.48  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQN--------ETDIkhLRKLKHPNIIAFKGVCTQAPCYCII 231
Cdd:cd05039    1 WAINKKDLKLGELIGKGEFGDVMLGDYRGQKVAVKCLKDDStaaqaflaEASV--MTTLRHPNLVQLLGVVLEGNGLYIV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRA-GRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK 309
Cdd:cd05039   79 TEYMAKGSLVDYLRSrGRAvITRKDQLGFALDVCEGMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFGLAKEASSNQDG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 MSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQT 388
Cdd:cd05039  159 GKLP--IKWTAPEALREKKFSTKSDVWSFGILLWEIYSfGRVPYPRIPLKDVVPHV-EKGYRMEAPEGCPPEVYKVMKNC 235
                        250
                 ....*....|....*...
gi 755554055 389 WQSKPRNRPSFRQTLMHL 406
Cdd:cd05039  236 WELDPAKRPTFKQLREKL 253
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
173-403 3.31e-52

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 183.43  E-value: 3.31e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKV---------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd08215    8 IGKGSFGSAYLVRRKSdgKLYVLKEIdlsnmsekeREEALNEVKLLSKLKHPNIVKYYESFEENGKLCIVMEYADGGDLA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRA----GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-MSFAGTV 316
Cdd:cd08215   88 QKIKKqkkkGQPFPEEQILDWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFGISKVLESTTDLaKTVVGTP 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKdvdssaiiwgvgSNSLHL-----------PVPSTCPDGFKILM 385
Cdd:cd08215  168 YYLSPELCENKPYNYKSDIWALGCVLYELCTLKHPFE------------ANNLPAlvykivkgqypPIPSQYSSELRDLV 235
                        250
                 ....*....|....*...
gi 755554055 386 KQTWQSKPRNRPSFRQTL 403
Cdd:cd08215  236 NSMLQKDPEKRPSANEIL 253
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
173-398 3.85e-51

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 180.48  E-value: 3.85e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14014    8 LGRGGMGEVYRARDTLLgrPVAIKVLRPELAEDeefrerflreARALARLSHPNIVRVYDVGEDDGRPYIVMEYVEGGSL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS--FAGTVAW 318
Cdd:cd14014   88 ADLLRERGPLPPREALRILAQIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALGDSGLTQTgsVLGTPAY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSTCPDGFKILMKQTWQSKPRNR 396
Cdd:cd14014  168 MAPEQARGGPVDPRSDIYSLGVVLYELLTGRPPFDGDSPAAVLAKHLQEAPPPPspLNPDVPPALDAIILRALAKDPEER 247

                 ..
gi 755554055 397 PS 398
Cdd:cd14014  248 PQ 249
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
173-405 1.95e-50

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 178.57  E-value: 1.95e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVRE-----------QNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd06627    8 IGRGAFGSVYKGlnLNTGEFVAIKQISLekipksdlksvMGEIDL--LKKLNHPNIVKYIGSVKTKDSLYIILEYVENGS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKItPRLLVDWSTG-IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVA 317
Cdd:cd06627   86 LASIIKKFGKF-PESLVAVYIYqVLEGLAYLHEQGVIHRDIKGANILTTKDGLVKLADFGVATKLNEVEKDEnSVVGTPY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDGFKILMKQTWQSKPRNRP 397
Cdd:cd06627  165 WMAPEVIEMSGVTTASDIWSVGCTVIELLTGNPPYYDLQPMAALFRIVQDD-HPPLPENISPELRDFLLQCFQKDPTLRP 243

                 ....*...
gi 755554055 398 SFRQTLMH 405
Cdd:cd06627  244 SAKELLKH 251
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
166-403 7.87e-50

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 176.87  E-value: 7.87e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE-EVAIKKVRE--QNETD----IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05059    5 ELTFLKELGSGQFGVVHLGKWRGKiDVAIKMIKEgsMSEDDfieeAKVMMKLSHPKLVQLYGVCTKQRPIFIVTEYMANG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKI-TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFaGT-- 315
Cdd:cd05059   85 CLLNYLRERRGKfQTEQLLEMCKDVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDDEYTSSV-GTkf 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 -VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd05059  164 pVKWSPPEVFMYSKFSSKSDVWSFGVLMWEVFSeGKMPYERFSNSEVVEHI-SQGYRLYRPHLAPTEVYTIMYSCWHEKP 242
                        250
                 ....*....|
gi 755554055 394 RNRPSFRQTL 403
Cdd:cd05059  243 EERPTFKILL 252
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
173-399 2.55e-47

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 169.39  E-value: 2.55e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-EVAIKKVREQNET------DIKHLRKLKHPNIIAFKGVCTQA-PCYcIIMEYCAHGQLYEVL 244
Cdd:cd05034    3 LGAGQFGEVWMGVWNGTtKVAVKTLKPGTMSpeaflqEAQIMKKLRHDKLVQLYAVCSDEePIY-IVTELMSKGSLLDYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 R--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSFAGT---VAWM 319
Cdd:cd05034   82 RtgEGRALRLPQLIDMAAQIASGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLIED-DEYTAREGAkfpIKWT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 320 APEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 398
Cdd:cd05034  161 APEAALYGRFTIKSDVWSFGILLYEIVTyGRVPYPGMTNREVLEQVERG-YRMPKPPGCPDELYDIMLQCWKKEPEERPT 239

                 .
gi 755554055 399 F 399
Cdd:cd05034  240 F 240
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
173-405 6.40e-47

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 168.46  E-value: 6.40e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKV-REQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14003    8 LGEGSFGKVKLArhKLTGEKVAIKIIdKSKLKEEieekikreIEIMKLLNHPNIIKLYEVIETENKIYLVMEYASGGELF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITP---RLLVdwsTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14003   88 DYIVNNGRLSEdeaRRFF---QQLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFRGGSLLKTFCGTPAY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVgsNSLHLPVPSTCPDGFKILMKQTWQSKPRNRP 397
Cdd:cd14003  165 AAPEVLLGRKYdGPKADVWSLGVILYAMLTGYLPFDDDNDSKLFRKI--LKGKYPIPSHLSPDARDLIRRMLVVDPSKRI 242

                 ....*...
gi 755554055 398 SFRQTLMH 405
Cdd:cd14003  243 TIEEILNH 250
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
162-400 8.54e-47

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 169.10  E-value: 8.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 162 VPFEEISELQWLGSGAQGAVFLGKF------RAEEVAIKKVR----EQNETD----IKHLRKLKHPNIIAFKGVCTQA-- 225
Cdd:cd05038    1 FEERHLKFIKQLGEGHFGSVELCRYdplgdnTGEQVAVKSLQpsgeEQHMSDfkreIEILRTLDHEYIVKYKGVCESPgr 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS 304
Cdd:cd05038   81 RSLRLIMEYLPSGSLRDYLQRHRdQIDLKRLLLFASQICKGMEYLGSQRYIHRDLAARNILVESEDLVKISDFGLAKVLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 305 DKS----TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTgeipYKDVDSSAI------IWGVGSNSLH---- 370
Cdd:cd05038  161 EDKeyyyVKEPGESPIFWYAPECLRESRFSSASDVWSFGVTLYELFT----YGDPSQSPPalflrmIGIAQGQMIVtrll 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 755554055 371 --------LPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05038  237 ellksgerLPRPPSCPDEVYDLMKECWEYEPQDRPSFS 274
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
160-407 2.67e-46

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 167.98  E-value: 2.67e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLG------KFRAEE--VAIKKVREQ-NETDIKHL------RKL--KHPNIIAFKGVC 222
Cdd:cd05053    7 WELPRDRLTLGKPLGEGAFGQVVKAeavgldNKPNEVvtVAVKMLKDDaTEKDLSDLvsememMKMigKHKNIINLLGAC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQA-PCYcIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 285
Cdd:cd05053   87 TQDgPLY-VVVEYASKGNLREFLRARRppgeeaspddprvpeeQLTQKDLVSFAYQVARGMEYLASKKCIHRDLAARNVL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 286 VTHTDAVKISDFGTSKELSD-----KSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKdvdssa 359
Cdd:cd05053  166 VTEDNVMKIADFGLARDIHHidyyrKTTNGRLP--VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTlGGSPYP------ 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 360 iiwGVGSNSL--------HLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05053  238 ---GIPVEELfkllkeghRMEKPQNCTQELYMLMRDCWHEVPSQRPTFKQLVEDLD 290
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
162-401 3.12e-46

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 167.26  E-value: 3.12e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 162 VPFEEISELQWLGSGAQGAVFLGKFRAEEV----------AIKKVREQN-------ETDIkhLRKLKHPNIIAFKGVCTQ 224
Cdd:cd05046    2 FPRSNLQEITTLGRGEFGEVFLAKAKGIEEeggetlvlvkALQKTKDENlqsefrrELDM--FRKLSHKNVVRLLGLCRE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 225 APCYCIIMEYCAHGQLYEVLRAGRK---------ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKIS 295
Cdd:cd05046   80 AEPHYMILEYTDLGDLKQFLRATKSkdeklkpppLSTKQKVALCTQIALGMDHLSNARFVHRDLAARNCLVSSQREVKVS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 296 DFGTSKELSD------KSTKMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNS 368
Cdd:cd05046  160 LLSLSKDVYNseyyklRNALIP----LRWLAPEAVQEDDFSTKSDVWSFGVLMWEVFTqGELPFYGLSDEEVLNRLQAGK 235
                        250       260       270
                 ....*....|....*....|....*....|...
gi 755554055 369 LHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05046  236 LELPVPEGCPSRLYKLMTRCWAVNPKDRPSFSE 268
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
173-405 4.79e-46

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 166.11  E-value: 4.79e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKV---------RE--QNETDIkhLRKLKHPNIIAFKGV-CTQApCYCIIMEYCAHG 238
Cdd:cd05117    8 LGRGSFGVVRLAVHKKtgEEYAVKIIdkkklksedEEmlRREIEI--LKRLDHPNIVKLYEVfEDDK-NLYLVMELCTGG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd05117   85 ELFDRIVKKGSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLASKDPdspIKIIDFGLAKIFEEGEKLKTVCGT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL--PVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd05117  165 PYYVAPEVLKGKGYGKKCDIWSLGVILYILLCGYPPFYGETEQELFEKILKGKYSFdsPEWKNVSEEAKDLIKRLLVVDP 244
                        250
                 ....*....|..
gi 755554055 394 RNRPSFRQTLMH 405
Cdd:cd05117  245 KKRLTAAEALNH 256
Pkinase pfam00069
Protein kinase domain;
173-405 7.14e-46

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 163.95  E-value: 7.14e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKH---------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:pfam00069   7 LGSGSFGTVYKAKHRDtgKIVAIKKIKKEKIKKKKDknilreikiLKKLNHPNIVRLYDAFEDKDNLYLVLEYVEGGSLF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  242 EVLRAGRKITPRLLVDWSTGIASGMNYlhlhkiihrdlkspnvlvthtdavkisdfgtskelsdKSTKMSFAGTVAWMAP 321
Cdd:pfam00069  87 DLLSEKGAFSEREAKFIMKQILEGLES-------------------------------------GSSLTTFVGTPWYMAP 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  322 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP-VPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:pfam00069 130 EVLGGNPYGPKVDVWSLGCILYELLTGKPPFPGINGNEIYELIIDQPYAFPeLPSNLSEEAKDLLKKLLKKDPSKRLTAT 209

                  ....*
gi 755554055  401 QTLMH 405
Cdd:pfam00069 210 QALQH 214
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
165-406 1.22e-45

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 164.74  E-value: 1.22e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVRE--QNETDIKH----LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd05112    4 SELTFVQEIGSGQFGLVHLGYWLNKdKVAIKTIREgaMSEEDFIEeaevMMKLSHPKLVQLYGVCLEQAPICLVFEFMEH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-ELSDKSTkmSFAGT 315
Cdd:cd05112   84 GCLSDYLRTQRgLFSAETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVVKVSDFGMTRfVLDDQYT--SSTGT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 ---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQS 391
Cdd:cd05112  162 kfpVKWSSPEVFSFSRYSSKSDVWSFGVLMWEVFSeGKIPYENRSNSEVVEDI-NAGFRLYKPRLASTHVYEIMNHCWKE 240
                        250
                 ....*....|....*
gi 755554055 392 KPRNRPSFRQTLMHL 406
Cdd:cd05112  241 RPEDRPSFSLLLRQL 255
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
158-403 1.56e-45

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 164.89  E-value: 1.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVPFEEISELQWLGSGAQGAVFLGKF-RAEEVAIKKVR--EQNETDI----KHLRKLKHPNIIAFKGVCTQA-PCYc 229
Cdd:cd05068    1 DQWEIDRKSLKLLRKLGSGQFGEVWEGLWnNTTPVAVKTLKpgTMDPEDFlreaQIMKKLRHPKLIQLYAVCTLEePIY- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd05068   80 IITELMKHGSLLEYLQGkGRSLQLPQLIDMAAQVASGMAYLESQNYIHRDLAARNVLVGENNICKVADFGLARVIKVEDE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKIL 384
Cdd:cd05068  160 YEAREGAkfpIKWTAPEAANYNRFSIKSDVWSFGILLTEIVTyGRIPYPGMTNAEVLQQV-ERGYRMPCPPNCPPQLYDI 238
                        250
                 ....*....|....*....
gi 755554055 385 MKQTWQSKPRNRPSFrQTL 403
Cdd:cd05068  239 MLECWKADPMERPTF-ETL 256
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
173-364 1.65e-45

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 171.35  E-value: 1.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:COG0515   15 LGRGGMGVVYLARDLRlgRPVALKVLRPELAADpearerfrreARALARLNHPNIVRVYDVGEEDGRPYLVMEYVEGESL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS--FAGTVAW 318
Cdd:COG0515   95 ADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTgtVVGTPGY 174
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV 364
Cdd:COG0515  175 MAPEQARGEPVDPRSDVYSLGVTLYELLTGRPPFDGDSPAELLRAH 220
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
161-406 2.41e-45

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 164.86  E-value: 2.41e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKF-------RAEEVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQA 225
Cdd:cd05048    1 EIPLSAVRFLEELGEGAFGKVYKGELlgpsseeSAISVAIKTLKENASPKTQQdfrreaelMSDLQHPNIVCLLGVCTKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYE--VLRA----------GRKITPRL----LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT 289
Cdd:cd05048   81 QPQCMLFEYMAHGDLHEflVRHSphsdvgvssdDDGTASSLdqsdFLHIAIQIAAGMEYLSSHHYVHRDLAARNCLVGDG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 290 DAVKISDFGTSKEL--SD----KSTKMSfagTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIW 362
Cdd:cd05048  161 LTVKISDFGLSRDIysSDyyrvQSKSLL---PVRWMPPEAILYGKFTTESDVWSFGVVLWEIFSyGLQPYYGYSNQEVIE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 755554055 363 GVGSNSLhLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05048  238 MIRSRQL-LPCPEDCPARVYSLMVECWHEIPSRRPRFKEIHTRL 280
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
160-407 2.71e-45

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 164.44  E-value: 2.71e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLG------KFRAE-EVAIKKVREQ----------NETDIkhLRKLKHPNIIAFKGVC 222
Cdd:cd05032    1 WELPREKITLIRELGQGSFGMVYEGlakgvvKGEPEtRVAIKTVNENasmrerieflNEASV--MKEFNCHHVVRLLGVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQAPCYCIIMEYCAHGQLYEVLRAGRK----------ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV 292
Cdd:cd05032   79 STGQPTLVVMELMAKGDLKSYLRSRRPeaennpglgpPTLQKFIQMAAEIADGMAYLAAKKFVHRDLAARNCMVAEDLTV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 293 KISDFGTSKEL--SD---KSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGS 366
Cdd:cd05032  159 KIGDFGMTRDIyeTDyyrKGGKGLLP--VRWMAPESLKDGVFTTKSDVWSFGVVLWEMATlAEQPYQGLSNEEVLKFVID 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 755554055 367 NSlHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05032  237 GG-HLDLPENCPDKLLELMRMCWQYNPKMRPTFLEIVSSLK 276
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
173-405 4.49e-45

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 163.03  E-value: 4.49e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIK----------KVREQNETDIKHLRKLKHPNII----AF---KGVctqapcYcIIME 233
Cdd:cd14007    8 LGKGKFGNVYLAREKKSgfIVALKvisksqlqksGLEHQLRREIEIQSHLRHPNILrlygYFedkKRI------Y-LILE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSFA 313
Cdd:cd14007   81 YAPNGELYKELKKQKRFDEKEAAKYIYQLALALDYLHSKNIIHRDIKPENILLGSNGELKLADFGWSVHAPS-NRRKTFC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI---IwgvgsNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd14007  160 GTLDYLPPEMVEGKEYDYKVDIWSLGVLCYELLVGKPPFESKSHQETykrI-----QNVDIKFPSSVSPEAKDLISKLLQ 234
                        250
                 ....*....|....*
gi 755554055 391 SKPRNRPSFRQTLMH 405
Cdd:cd14007  235 KDPSKRLSLEQVLNH 249
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
163-398 6.13e-45

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 163.32  E-value: 6.13e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQ-----------NEtdiKHLRKLKHPNII---AFKGVCTQAPCY 228
Cdd:cd13979    1 DWEPLRLQEPLGSGGFGSVYKATYKGETVAVKIVRRRrknrasrqsfwAE---LNAARLRHENIVrvlAAETGTDFASLG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITP---RLLVdwSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-- 303
Cdd:cd13979   78 LIIMEYCGNGTLQQLIYEGSEPLPlahRILI--SLDIARALRFCHSHGIVHLDVKPANILISEQGVCKLCDFGCSVKLge 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 -SDKSTKMS-FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDvDSSAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd13979  156 gNEVGTPRShIGGTYTYRAPELLKGERVTPKADIYSFGITLWQMLTRELPYAG-LRQHVLYAVVAKDLRPDLSGLEDSEF 234
                        250       260
                 ....*....|....*....|.
gi 755554055 382 ----KILMKQTWQSKPRNRPS 398
Cdd:cd13979  235 gqrlRSLISRCWSAQPAERPN 255
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
173-407 9.21e-45

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 162.18  E-value: 9.21e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEeVAIKKVR------EQ-----NETDIkhLRKLKHPNIIAFKGVCTqAPCYCIIMEYCAHGQLY 241
Cdd:cd14062    1 IGSGSFGTVYKGRWHGD-VAVKKLNvtdptpSQlqafkNEVAV--LRKTRHVNILLFMGYMT-KPQLAIVTQWCEGSSLY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLR-AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF---AGTVA 317
Cdd:cd14062   77 KHLHvLETKFEMLQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGLATVKTRWSGSQQFeqpTGSIL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNE---PVSEKVDIWSFGVVLWELLTGEIPYKDVDSS-AIIWGVGSNSLHlP----VPSTCPDGFKILMKQTW 389
Cdd:cd14062  157 WMAPEVIRMQdenPYSFQSDVYAFGIVLYELLTGQLPYSHINNRdQILFMVGRGYLR-PdlskVRSDTPKALRRLMEDCI 235
                        250
                 ....*....|....*...
gi 755554055 390 QSKPRNRPSFRQTLMHLD 407
Cdd:cd14062  236 KFQRDERPLFPQILASLE 253
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
173-399 2.61e-44

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 160.98  E-value: 2.61e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-----EVAIKKVREQNETDIKH--LR------KLKHPNIIAFKGVCtQAPCYCIIMEYCAHGQ 239
Cdd:cd05060    3 LGHGNFGSVRKGVYLMKsgkevEVAVKTLKQEHEKAGKKefLReasvmaQLDHPCIVRLIGVC-KGEPLMLVMELAPLGP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST--KMSFAGT-- 315
Cdd:cd05060   82 LLKYLKKRREIPVSDLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGMSRALGAGSDyyRATTAGRwp 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd05060  162 LKWYAPECINYGKFSSKSDVWSYGVTLWEAFSyGAKPYGEMKGPEVIAMLESG-ERLPRPEECPQEIYSIMLSCWKYRPE 240

                 ....*
gi 755554055 395 NRPSF 399
Cdd:cd05060  241 DRPTF 245
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
171-399 5.03e-44

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 160.10  E-value: 5.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQA-PCYcIIMEYCAHGQ 239
Cdd:cd05084    2 ERIGRGNFGEVFSGRLRADNtpVAVKSCRETLPPDLKAkflqeariLKQYSHPNIVRLIGVCTQKqPIY-IVMELVQGGD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---KSTKMSFAGT 315
Cdd:cd05084   81 FLTFLRTeGPRLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDgvyAATGGMKQIP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSS----AIIWGVgsnslHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd05084  161 VKWTAPEALNYGRYSSESDVWSFGILLWETFSlGAVPYANLSNQqtreAVEQGV-----RLPCPENCPDEVYRLMEQCWE 235

                 ....*....
gi 755554055 391 SKPRNRPSF 399
Cdd:cd05084  236 YDPRKRPSF 244
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
173-412 5.27e-44

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 160.45  E-value: 5.27e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKV--------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd06623    9 LGQGSSGVVYKVRHKPtgKIYALKKIhvdgdeefRKQLLRELKTLRSCESPYVVKCYGAFYKEGEISIVLEYMDGGSLAD 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHL-HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-MSFAGTVAWMA 320
Cdd:cd06623   89 LLKKVGKIPEPVLAYIARQILKGLDYLHTkRHIIHRDIKPSNLLINSKGEVKIADFGISKVLENTLDQcNTFVGTVTYMS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 321 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS-------AIiwgVGSNSLHLPvPSTCPDGFKILMKQTWQSKP 393
Cdd:cd06623  169 PERIQGESYSYAADIWSLGLTLLECALGKFPFLPPGQPsffelmqAI---CDGPPPSLP-AEEFSPEFRDFISACLQKDP 244
                        250
                 ....*....|....*....
gi 755554055 394 RNRPSFRQTLMHLDIASAD 412
Cdd:cd06623  245 KKRPSAAELLQHPFIKKAD 263
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
161-401 7.67e-44

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 160.66  E-value: 7.67e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRAE------EVAIKKVRE----QNETDI----KHLRKLKHPNIIAFKGVCTqAP 226
Cdd:cd05057    3 IVKETELEKGKVLGSGAFGTVYKGVWIPEgekvkiPVAIKVLREetgpKANEEIldeaYVMASVDHPHLVRLLGICL-SS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD 305
Cdd:cd05057   82 QVQLITQLMPLGCLLDYVRNHRdNIGSQLLLNWCVQIAKGMSYLEEKRLVHRDLAARNVLVKTPNHVKITDFGLAKLLDV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAG---TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGF 381
Cdd:cd05057  162 DEKEYHAEGgkvPIKWMALESIQYRIYTHKSDVWSYGVTVWELMTfGAKPYEGIPAVEIPDLL-EKGERLPQPPICTIDV 240
                        250       260
                 ....*....|....*....|
gi 755554055 382 KILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05057  241 YMVLVKCWMIDAESRPTFKE 260
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
173-399 1.94e-43

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 158.38  E-value: 1.94e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd05041    3 IGRGNFGDVYRGVLKPDntEVAVKTCRETLPPDLKRkflqeariLKQYDHPNIVKLIGVCVQKQPIMIVMELVPGGSLLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLR-AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSfAGT----VA 317
Cdd:cd05041   83 FLRkKGARLTVKQLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMSREEEDGEYTVS-DGLkqipIK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQTWQSKPRNR 396
Cdd:cd05041  162 WTAPEALNYGRYTSESDVWSFGILLWEIFSlGATPYPGMSNQQTREQIESG-YRMPAPELCPEAVYRLMLQCWAYDPENR 240

                 ...
gi 755554055 397 PSF 399
Cdd:cd05041  241 PSF 243
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
160-402 2.19e-43

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 158.74  E-value: 2.19e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLG--KFRAEEVAIKKVREQN--------ETDIkhLRKLKHPNIIAFKGVCTQAPCYC 229
Cdd:cd05052    1 WEIERTDITMKHKLGGGQYGEVYEGvwKKYNLTVAVKTLKEDTmeveeflkEAAV--MKEIKHPNLVQLLGVCTREPPFY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkS 307
Cdd:cd05052   79 IITEFMPYGNLLDYLRECNReeLNAVVLLYMATQIASAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG-D 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAiIWGVGSNSLHLPVPSTCPDGFKI 383
Cdd:cd05052  158 TYTAHAGAkfpIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATyGMSPYPGIDLSQ-VYELLEKGYRMERPEGCPPKVYE 236
                        250
                 ....*....|....*....
gi 755554055 384 LMKQTWQSKPRNRPSFRQT 402
Cdd:cd05052  237 LMRACWQWNPSDRPSFAEI 255
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
160-399 2.40e-43

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 158.51  E-value: 2.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRA-EEVAIKKVREQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYcIIM 232
Cdd:cd05067    2 WEVPRETLKLVERLGAGQFGEVWMGYYNGhTKVAIKSLKQGSMSpdaflaEANLMKQLQHQRLVRLYAVVTQEPIY-IIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLR--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK--ELSDKST 308
Cdd:cd05067   81 EYMENGSLVDFLKtpSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARliEDNEYTA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQ 387
Cdd:cd05067  161 REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVThGRIPYPGMTNPEVIQNLERG-YRMPRPDNCPEELYQLMRL 239
                        250
                 ....*....|..
gi 755554055 388 TWQSKPRNRPSF 399
Cdd:cd05067  240 CWKERPEDRPTF 251
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
171-405 2.50e-43

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 158.33  E-value: 2.50e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFL------GKFRA-EEVAI----KKVRE---QNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd06632    6 QLLGSGSFGSVYEgfngdtGDFFAvKEVSLvdddKKSREsvkQLEQEIALLSKLRHPNIVQYYGTEREEDNLYIFLEYVP 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTV 316
Cdd:cd06632   86 GGSIHKLLQRYGAFEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGMAKHVEAFSFAKSFKGSP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIR--NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd06632  166 YWMAPEVIMqkNSGYGLAVDIWSLGCTVLEMATGKPPWSQYEGVAAIFKIGNSGELPPIPDHLSPDAKDFIRLCLQRDPE 245
                        250
                 ....*....|.
gi 755554055 395 NRPSFRQTLMH 405
Cdd:cd06632  246 DRPTASQLLEH 256
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
168-405 4.39e-43

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 157.37  E-value: 4.39e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 168 SELQWLGSGAQGAVFLGKFRA--EEVAIKK--VREQNE----TDIKHLRKLKHPNIIAFKGvctqapCYC------IIME 233
Cdd:cd06614    3 KNLEKIGEGASGEVYKATDRAtgKEVAIKKmrLRKQNKeliiNEILIMKECKHPNIVDYYD------SYLvgdelwVVME 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAgrkiTPRLLVDwsTGIA-------SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-D 305
Cdd:cd06614   77 YMDGGSLTDIITQ----NPVRMNE--SQIAyvcrevlQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLTkE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLH-LPVPSTCPDGFKIL 384
Cdd:cd06614  151 KSKRNSVVGTPYWMAPEVIKRKDYGPKVDIWSLGIMCIEMAEGEPPYLEEPPLRALFLITTKGIPpLKNPEKWSPEFKDF 230
                        250       260
                 ....*....|....*....|.
gi 755554055 385 MKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06614  231 LNKCLVKDPEKRPSAEELLQH 251
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
167-407 5.81e-43

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 157.53  E-value: 5.81e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVFLGKFR-----AEEVAIKKVREQNE--------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd05033    6 VTIEKVIGGGEFGEVCSGSLKlpgkkEIDVAIKTLKSGYSdkqrldflTEASIMGQFDHPNVIRLEGVVTKSRPVMIVTE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF 312
Cdd:cd05033   86 YMENGSLDKFLRENDgKFTVTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSRRLEDSEATYTT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AG---TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQT 388
Cdd:cd05033  166 KGgkiPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSyGERPYWDMSNQDVIKAVEDG-YRLPPPMDCPSALYQLMLDC 244
                        250
                 ....*....|....*....
gi 755554055 389 WQSKPRNRPSFRQTLMHLD 407
Cdd:cd05033  245 WQKDRNERPTFSQIVSTLD 263
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
160-400 1.47e-42

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 156.06  E-value: 1.47e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCII 231
Cdd:cd05148    1 WERPREEFTLERKLGSGYFGEVWEGLWKNRvRVAIKILKSDDLlkqqdfqKEVQALKRLRHKHLISLFAVCSVGEPVYII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---- 305
Cdd:cd05148   81 TELMEKGSLLAFLRSpeGQVLPVASLIDMACQVAEGMAYLEEQNSIHRDLAARNILVGEDLVCKVADFGLARLIKEdvyl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 -KSTKMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNsLHLPVPSTCPDGFKI 383
Cdd:cd05148  161 sSDKKIP----YKWTAPEAASHGTFSTKSDVWSFGILLYEMFTyGQVPYPGMNNHEVYDQITAG-YRMPCPAKCPQEIYK 235
                        250
                 ....*....|....*..
gi 755554055 384 LMKQTWQSKPRNRPSFR 400
Cdd:cd05148  236 IMLECWAAEPEDRPSFK 252
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
173-399 2.97e-42

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 155.19  E-value: 2.97e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-----VAIKKVREQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYcIIMEYCAH 237
Cdd:cd05040    3 LGDGSFGVVRRGEWTTPSgkviqVAVKCLKSDVLSQpnamddflkeVNAMHSLDHPNLIRLYGVVLSSPLM-MVTELAPL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS--DKSTKMSFAG 314
Cdd:cd05040   82 GSLLDRLRKDQGHFLiSTLCDYAVQIANGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLMRALPqnEDHYVMQEHR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TV--AWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS 391
Cdd:cd05040  162 KVpfAWCAPESLKTRKFSHASDVWMFGVTLWEMFTyGEEPWLGLNGSQILEKIDKEGERLERPDDCPQDIYNVMLQCWAH 241

                 ....*...
gi 755554055 392 KPRNRPSF 399
Cdd:cd05040  242 KPADRPTF 249
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
160-399 3.42e-42

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 155.58  E-value: 3.42e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFR-AEEVAIKKVREQNET------DIKHLRKLKHPNIIAFKGVCTQA-PCYcII 231
Cdd:cd05072    2 WEIPRESIKLVKKLGAGQFGEVWMGYYNnSTKVAVKTLKPGTMSvqafleEANLMKTLQHDKLVRLYAVVTKEePIY-II 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRA---GRKITPRLlVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK-- 306
Cdd:cd05072   81 TEYMAKGSLLDFLKSdegGKVLLPKL-IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNey 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILM 385
Cdd:cd05072  160 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLYEIVTyGKIPYPGMSNSDVMSAL-QRGYRMPRMENCPDELYDIM 238
                        250
                 ....*....|....
gi 755554055 386 KQTWQSKPRNRPSF 399
Cdd:cd05072  239 KTCWKEKAEERPTF 252
PTKc_DDR cd05051
Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze ...
192-406 3.62e-42

Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The DDR subfamily consists of homologs of mammalian DDR1, DDR2, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270644 [Multi-domain]  Cd Length: 297  Bit Score: 156.34  E-value: 3.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 192 AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA------------GRKITPRLLVDWS 259
Cdd:cd05051   58 ASKNAREDFLKEVKIMSQLKDPNIVRLLGVCTRDEPLCMIVEYMENGDLNQFLQKheaetqgasatnSKTLSYGTLLYMA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsdkstkmsFAGT-----------VAWMAPEVIRNEP 328
Cdd:cd05051  138 TQIASGMKYLESLNFVHRDLATRNCLVGPNYTIKIADFGMSRNL--------YSGDyyriegravlpIRWMAWESILLGK 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 329 VSEKVDIWSFGVVLWELLT--GEIPYKDVDSSAIIWGVG------SNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05051  210 FTTKSDVWAFGVTLWEILTlcKEQPYEHLTDEQVIENAGeffrddGMEVYLSRPPNCPKEIYELMLECWRRDEEDRPTFR 289

                 ....*.
gi 755554055 401 QtlMHL 406
Cdd:cd05051  290 E--IHL 293
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
158-407 9.59e-42

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 154.45  E-value: 9.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEeVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQaPCY 228
Cdd:cd14151    1 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTpqqlqafknEVGVLRKTRHVNILLFMGYSTK-PQL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKS 307
Cdd:cd14151   79 AIVTQWCEGSSLYHHLHIIEtKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSF---AGTVAWMAPEVIR---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LPVPSTC 377
Cdd:cd14151  159 GSHQFeqlSGSILWMAPEVIRmqdKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNrDQIIFMVGRGYLSpdlSKVRSNC 238
                        250       260       270
                 ....*....|....*....|....*....|
gi 755554055 378 PDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14151  239 PKAMKRLMAECLKKKRDERPLFPQILASIE 268
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
165-412 2.19e-41

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 153.17  E-value: 2.19e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLG--KFRAEEVAIKKVR-EQNETDIKH-------LRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd06609    1 ELFTLLERIGKGSFGEVYKGidKRTNQVVAIKVIDlEEAEDEIEDiqqeiqfLSQCDSPYITKYYGSFLKGSKLWIIMEY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGR---KITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM- 310
Cdd:cd06609   81 CGGGSVLDLLKPGPldeTYIAFILRE----VLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLADFGVSGQLTSTMSKRn 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd06609  157 TFVGTPFWMAPEVIKQSGYDEKADIWSLGITAIELAKGEPPLSDLHPMRVLFLIPKNNPPSLEGNKFSKPFKDFVELCLN 236
                        250       260
                 ....*....|....*....|..
gi 755554055 391 SKPRNRPSFRQTLMHLDIASAD 412
Cdd:cd06609  237 KDPKERPSAKELLKHKFIKKAK 258
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
160-424 2.82e-41

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 154.35  E-value: 2.82e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFlgkfRAEEVAIKKVR------------EQNETDiKHLRKL-----------KHPNII 216
Cdd:cd05099    7 WEFPRDRLVLGKPLGEGCFGQVV----RAEAYGIDKSRpdqtvtvavkmlKDNATD-KDLADLisemelmkligKHKNII 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 217 AFKGVCTQ-APCYcIIMEYCAHGQLYEVLRAGRKITPRL----------------LVDWSTGIASGMNYLHLHKIIHRDL 279
Cdd:cd05099   82 NLLGVCTQeGPLY-VIVEYAAKGNLREFLRARRPPGPDYtfditkvpeeqlsfkdLVSCAYQVARGMEYLESRRCIHRDL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 280 KSPNVLVTHTDAVKISDFGTSKELSD-----KSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYK 353
Cdd:cd05099  161 AARNVLVTEDNVMKIADFGLARGVHDidyykKTSNGRLP--VKWMAPEALFDRVYTHQSDVWSFGILMWEIFTlGGSPYP 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 354 DVDSSAiIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADV------LATPQETYFKS 424
Cdd:cd05099  239 GIPVEE-LFKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLVEALDKVLAAVseeyldLSMPFEQYSPS 314
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
165-403 3.35e-41

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 151.96  E-value: 3.35e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVRE--QNETDI----KHLRKLKHPNIIAFKGVCT-QAPCYcIIMEYCA 236
Cdd:cd05113    4 KDLTFLKELGTGQFGVVKYGKWRGQyDVAIKMIKEgsMSEDEFieeaKVMMNLSHEKLVQLYGVCTkQRPIF-IITEYMA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTkmSFAG 314
Cdd:cd05113   83 NGCLLNYLREMRKrFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYvLDDEYT--SSVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 T---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd05113  161 SkfpVRWSPPEVLMYSKFSSKSDVWAFGVLMWEVYSlGKMPYERFTNSETVEHV-SQGLRLYRPHLASEKVYTIMYSCWH 239
                        250
                 ....*....|...
gi 755554055 391 SKPRNRPSFRQTL 403
Cdd:cd05113  240 EKADERPTFKILL 252
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
160-401 4.29e-41

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 151.67  E-value: 4.29e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET-----DIKHLRKLKHPNIIAFKGVCTQ--APCYcIIM 232
Cdd:cd05082    1 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAqaflaEASVMTQLRHSNLVQLLGVIVEekGGLY-IVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRA-GRKITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSdkSTKM 310
Cdd:cd05082   80 EYMAKGSLVDYLRSrGRSVLGgDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS--STQD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTW 389
Cdd:cd05082  158 TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSfGRVPYPRIPLKDVVPRV-EKGYKMDAPDGCPPAVYDVMKNCW 236
                        250
                 ....*....|..
gi 755554055 390 QSKPRNRPSFRQ 401
Cdd:cd05082  237 HLDAAMRPSFLQ 248
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
171-405 2.09e-40

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 150.22  E-value: 2.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLG--KFRAEEVAIKKVrEQNETD------------------IKHLRKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd06629    7 ELIGKGTYGRVYLAmnATTGEMLAVKQV-ELPKTSsdradsrqktvvdalkseIDTLKDLDHPNIVQYLGFEETEDYFSI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---KS 307
Cdd:cd06629   86 FLEYVPGGSIGSCLRKYGKFEEDLVRFFTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGISKKSDDiygNN 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRN--EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPS---TCPDGFK 382
Cdd:cd06629  166 GATSMQGSVFWMAPEVIHSqgQGYSAKVDIWSLGCVVLEMLAGRRPWSDDEAIAAMFKLGNKRSAPPVPEdvnLSPEALD 245
                        250       260
                 ....*....|....*....|...
gi 755554055 383 ILMKqTWQSKPRNRPSFRQTLMH 405
Cdd:cd06629  246 FLNA-CFAIDPRDRPTAAELLSH 267
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
166-408 3.89e-40

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 149.40  E-value: 3.89e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAEeVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQaPCYCIIMEYCA 236
Cdd:cd14150    1 EVSMLKRIGTGSFGTVFRGKWHGD-VAVKILKVTEPTpeqlqafknEMQVLRKTRHVNILLFMGFMTR-PNFAIITQWCE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLR-AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF--- 312
Cdd:cd14150   79 GSSLYRHLHvTETRFDTMQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVeqp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIR---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LPVPSTCPDGFKILM 385
Cdd:cd14150  159 SGSILWMAPEVIRmqdTNPYSFQSDVYAYGVVLYELMSGTLPYSNINNrDQIIFMVGRGYLSpdlSKLSSNCPKAMKRLL 238
                        250       260
                 ....*....|....*....|...
gi 755554055 386 KQTWQSKPRNRPSFRQTLMHLDI 408
Cdd:cd14150  239 IDCLKFKREERPLFPQILVSIEL 261
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
174-405 7.64e-40

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 148.60  E-value: 7.64e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQGAVFLG--KFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd06626    9 GEGTFGKVYTAvnLDTGELMAMKEIRFQDNDpktikeiadEMKVLEGLDHPNLVRYYGVEVHREEVYIFMEYCQEGTLEE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM------SFAGTV 316
Cdd:cd06626   89 LLRHGRILDEAVIRVYTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAVKLKNNTTTMapgevnSLVGTP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEK---VDIWSFGVVLWELLTGEIPYKDVDSS-AIIWGVGSNSlHLPVPST---CPDGFKILmKQTW 389
Cdd:cd06626  169 AYMAPEVITGNKGEGHgraADIWSLGCVVLEMATGKRPWSELDNEwAIMYHVGMGH-KPPIPDSlqlSPEGKDFL-SRCL 246
                        250
                 ....*....|....*.
gi 755554055 390 QSKPRNRPSFRQTLMH 405
Cdd:cd06626  247 ESDPKKRPTASELLDH 262
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
173-407 8.15e-40

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 148.06  E-value: 8.15e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVRE-----QNETD-----IKHLRKLKHPNIIAFKGVCTQAPC-YCIIMEYCAHGQLY 241
Cdd:cd14064    1 IGSGSFGKVYKGRCRNKIVAIKRYRAntycsKSDVDmfcreVSILCRLNHPCVIQFVGACLDDPSqFAIVTQYVSGGSLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRK-ITPRLLVDWSTGIASGMNYLH--LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL----SDKSTKMSfaG 314
Cdd:cd14064   81 SLLHEQKRvIDLQSKLIIAVDVAKGMEYLHnlTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLqsldEDNMTKQP--G 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd14064  159 NLRWMAPEVFtQCTRYSIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMRGWNAEP 238
                        250
                 ....*....|....
gi 755554055 394 RNRPSFRQTLMHLD 407
Cdd:cd14064  239 ESRPSFVEIVALLE 252
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
166-407 1.73e-39

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 147.32  E-value: 1.73e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE-EVAIKKVRE--QNETDI----KHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05114    5 ELTFMKELGSGLFGVVRLGKWRAQyKVAIKAIREgaMSEEDFieeaKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMENG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT-- 315
Cdd:cd05114   85 CLLNYLRQRRgKLSRDMLLSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSSGAKfp 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd05114  165 VKWSPPEVFNYSKFSSKSDVWSFGVLMWEVFTeGKMPFESKSNYEVVEMV-SRGHRLYRPKLASKSVYEVMYSCWHEKPE 243
                        250
                 ....*....|...
gi 755554055 395 NRPSFRQTLMHLD 407
Cdd:cd05114  244 GRPTFADLLRTIT 256
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
173-405 1.76e-39

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 147.68  E-value: 1.76e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVR----------------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd06628    8 IGSGSFGSVYLGmnASSGELMAVKQVElpsvsaenkdrkksmlDALQREIALLRELQHENIVQYLGSSSDANHLNIFLEY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM---- 310
Cdd:cd06628   88 VPGGSVATLLNNYGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLEANSLSTknng 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 ---SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPvPSTCPDGFKILMKQ 387
Cdd:cd06628  168 arpSLQGSVFWMAPEVVKQTSYTRKADIWSLGCLVVEMLTGTHPFPDCTQMQAIFKIGENASPTI-PSNISSEARDFLEK 246
                        250
                 ....*....|....*...
gi 755554055 388 TWQSKPRNRPSFRQTLMH 405
Cdd:cd06628  247 TFEIDHNKRPTADELLKH 264
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
173-359 4.82e-39

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 146.26  E-value: 4.82e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-VAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd14066    1 IGSGGFGTVYKGVLENGTvVAVKRLNEMNcaaskkefLTELEMLGRLRHPNLVRLLGYCLESDEKLLVYEYMPNGSLEDR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGRKITPrllVDWST------GIASGMNYLH---LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK---STKMS 311
Cdd:cd14066   81 LHCHKGSPP---LPWPQrlkiakGIARGLEYLHeecPPPIIHGDIKSSNILLDEDFEPKLTDFGLARLIPPSesvSKTSA 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA 359
Cdd:cd14066  158 VKGTIGYLAPEYIRTGRVSTKSDVYSFGVVLLELLTGKPAVDENRENA 205
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
160-401 1.30e-38

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 145.26  E-value: 1.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEE-----VAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAP 226
Cdd:cd05056    1 YEIQREDITLGRCIGEGQFGDVYQGVYMSPEnekiaVAVKTCKNCTSPSVREkflqeayiMRQFDHPHIVKLIGVITENP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYcIIMEYCAHGQLYEVLRAGRKITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD 305
Cdd:cd05056   81 VW-IVMELAPLGELRSYLQVNKYSLDlASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYMED 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGT--VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIwGVGSNSLHLPVPSTCPDGFK 382
Cdd:cd05056  160 ESYYKASKGKlpIKWMAPESINFRRFTSASDVWMFGVCMWEILMlGVKPFQGVKNNDVI-GRIENGERLPMPPNCPPTLY 238
                        250
                 ....*....|....*....
gi 755554055 383 ILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05056  239 SLMTKCWAYDPSKRPRFTE 257
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
173-405 1.77e-38

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 144.42  E-value: 1.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL------GKfraeEVAIKKVR------------EQNETDIKHLRKLKHPNIIAFKGvCTQAP-CYCIIME 233
Cdd:cd06625    8 LGQGAFGQVYLcydadtGR----ELAVKQVEidpinteaskevKALECEIQLLKNLQHERIVQYYG-CLQDEkSLSIFME 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD--KSTKM- 310
Cdd:cd06625   83 YMPGGSVKDEIKAYGALTENVTRKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKRLQTicSSTGMk 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd06625  163 SVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTTKPPWAEFEPMAAIFKIATQPTNPQLPPHVSEDARDFLSLIFV 242
                        250
                 ....*....|....*
gi 755554055 391 SKPRNRPSFRQTLMH 405
Cdd:cd06625  243 RNKKQRPSAEELLSH 257
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
164-407 4.86e-38

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 144.00  E-value: 4.86e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEE--ISELQWLGSGAQGAVFLGKF------RAEEVAIKKVREQN-------ETDIKHLRKLKHPNIIAFKGVCTQA--P 226
Cdd:cd14205    1 FEErhLKFLQQLGKGNFGSVEMCRYdplqdnTGEVVAVKKLQHSTeehlrdfEREIEILKSLQHDNIVKYKGVCYSAgrR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-S 304
Cdd:cd14205   81 NLRLIMEYLPYGSLRDYLQKHKeRIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLpQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 305 DK---STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT------------GEIPYKDVDSSAIIW---GVGS 366
Cdd:cd14205  161 DKeyyKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTyieksksppaefMRMIGNDKQGQMIVFhliELLK 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 755554055 367 NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14205  241 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVD 281
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
160-401 6.69e-38

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 142.70  E-value: 6.69e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVR----EQN---ETDIkhLRKLKHPNIIAFKGVCTQAPCYcIIM 232
Cdd:cd05083    1 WLLNLQKLTLGEIIGEGEFGAVLQGEYMGQKVAVKNIKcdvtAQAfleETAV--MTKLQHKNLVRLLGVILHNGLY-IVM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRA-GRKITPRL-LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK--ELSDKST 308
Cdd:cd05083   78 ELMSKGNLVNFLRSrGRALVPVIqLLQFSLDVAEGMEYLESKKLVHRDLAARNILVSEDGVAKISDFGLAKvgSMGVDNS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQ 387
Cdd:cd05083  158 RLP----VKWTAPEALKNKKFSSKSDVWSYGVLLWEVFSyGRAPYPKMSVKEVKEAV-EKGYRMEPPEGCPPDVYSIMTS 232
                        250
                 ....*....|....
gi 755554055 388 TWQSKPRNRPSFRQ 401
Cdd:cd05083  233 CWEAEPGKRPSFKK 246
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
165-405 7.89e-38

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 142.40  E-value: 7.89e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQW-LGSGAQGAVF--LGKFRAEEVAIKKVR-----EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd06612    2 EEVFDILEkLGEGSYGSVYkaIHKETGQVVAIKVVPveedlQEIIKEISILKQCDSPYIVKYYGSYFKNTDLWIVMEYCG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAG 314
Cdd:cd06612   82 AGSVSDIMKITNKtLTEEEIAAILYQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKLADFGVSGQLTDTMAKRnTVIG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd06612  162 TPFWMAPEVIQEIGYNNKADIWSLGITAIEMAEGKPPYSDIHPMRAIFMIPNKpPPTLSDPEKWSPEFNDFVKKCLVKDP 241
                        250
                 ....*....|..
gi 755554055 394 RNRPSFRQTLMH 405
Cdd:cd06612  242 EERPSAIQLLQH 253
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
150-407 1.86e-37

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 143.23  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 150 TDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLG------KFRAEE---VAIKKVREQ-NETDIKHL------RKL--K 211
Cdd:cd05101    9 SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAeavgidKDKPKEavtVAVKMLKDDaTEKDLSDLvsememMKMigK 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 212 HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKII 275
Cdd:cd05101   89 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRppgmeysydinrvpeeQMTFKDLVSCTYQLARGMEYLASQKCI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 276 HRDLKSPNVLVTHTDAVKISDFGTSKELSD-----KSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GE 349
Cdd:cd05101  169 HRDLAARNVLVTENNVMKIADFGLARDINNidyykKTTNGRLP--VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTlGG 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 350 IPYKDVDSSAiIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05101  247 SPYPGIPVEE-LFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 303
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
160-401 2.13e-37

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 142.62  E-value: 2.13e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVF------LGKFRAE-EVAIKKVREQNETDIKH--LRKLK-------HPNIIAFKGVCT 223
Cdd:cd05055   30 WEFPRNNLSFGKTLGAGAFGKVVeataygLSKSDAVmKVAVKMLKPTAHSSEREalMSELKimshlgnHENIVNLLGACT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 QA-PCYcIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd05055  110 IGgPIL-VITEYCCYGDLLNFLRRKREsfLTLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICDFGLA 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 301 KELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPST 376
Cdd:cd05055  189 RDIMNDSNYVVKGNArlpVKWMAPESIFNCVYTFESDVWSYGILLWEIFSlGSNPYPGMPVDSKFYKLIKEGYRMAQPEH 268
                        250       260
                 ....*....|....*....|....*
gi 755554055 377 CPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05055  269 APAEIYDIMKTCWDADPLKRPTFKQ 293
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
153-407 2.65e-37

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 142.46  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 153 KLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKF---------RAEEVAIKKVR-EQNETDIKHL------RKL--KHPN 214
Cdd:cd05098    1 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAigldkdkpnRVTKVAVKMLKsDATEKDLSDLisememMKMigKHKN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 215 IIAFKGVCTQ-APCYcIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHR 277
Cdd:cd05098   81 IINLLGACTQdGPLY-VIVEYASKGNLREYLQARRppgmeycynpshnpeeQLSSKDLVSCAYQVARGMEYLASKKCIHR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 278 DLKSPNVLVTHTDAVKISDFGTSKELS-----DKSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIP 351
Cdd:cd05098  160 DLAARNVLVTEDNVMKIADFGLARDIHhidyyKKTTNGRLP--VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTlGGSP 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 352 YKDVDSSAiIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05098  238 YPGVPVEE-LFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 292
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
173-348 2.85e-37

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 141.87  E-value: 2.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14158   23 LGEGGFGVVFKGYINDKNVAVKKLaamvdistedlTKQFEQEIQVMAKCQHENLVELLGYSCDGPQLCLVYTYMPNGSLL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLrAGRKITPRLLV----DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM---SFAG 314
Cdd:cd14158  103 DRL-ACLNDTPPLSWhmrcKIAQGTANGINYLHENNHIHRDIKSANILLDETFVPKISDFGLARASEKFSQTImteRIVG 181
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 315 TVAWMAPEVIRNEpVSEKVDIWSFGVVLWELLTG 348
Cdd:cd14158  182 TTAYMAPEALRGE-ITPKSDIFSFGVVLLEIITG 214
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
173-396 3.21e-37

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 140.34  E-value: 3.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV--AIKKVREQ------------NETDIkhLRKLKHPNII----AFKgvcTQAPCYcIIMEY 234
Cdd:cd05123    1 LGKGSFGKVLLVRKKDTGKlyAMKVLRKKeiikrkevehtlNERNI--LERVNHPFIVklhyAFQ---TEEKLY-LVLDY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFA 313
Cdd:cd05123   75 VPGGELFSHLSKEGRFPEERARFYAAEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKELSSDGDRTyTFC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIwgvgSNSLHLPV--PSTCPDGFKILMKQTWQS 391
Cdd:cd05123  155 GTPEYLAPEVLLGKGYGKAVDWWSLGVLLYEMLTGKPPFYAENRKEIY----EKILKSPLkfPEYVSPEAKSLISGLLQK 230

                 ....*
gi 755554055 392 KPRNR 396
Cdd:cd05123  231 DPTKR 235
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
173-399 3.56e-37

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 140.67  E-value: 3.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQNETDI---------KHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd13978    1 LGSGGFGTVSKARHVSWfgMVAIKCLHSSPNCIEerkallkeaEKMERARHSYVLPLLGVCVERRSLGLVMEYMENGSLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRagRKITPrllVDWSTG------IASGMNYLH-LHK-IIHRDLKSPNVLVTHTDAVKISDFGTSK------ELSDKS 307
Cdd:cd13978   81 SLLE--REIQD---VPWSLRfriiheIALGMNFLHnMDPpLLHHDLKPENILLDNHFHVKISDFGLSKlgmksiSANRRR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIR--NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGS-------NSLHLPVPSTCP 378
Cdd:cd13978  156 GTENLGGTPIYMAPEAFDdfNKKPTSKSDVYSFAIVIWAVLTRKEPFENAINPLLIMQIVSkgdrpslDDIGRLKQIENV 235
                        250       260
                 ....*....|....*....|.
gi 755554055 379 DGFKILMKQTWQSKPRNRPSF 399
Cdd:cd13978  236 QELISLMIRCWDGNPDARPTF 256
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
161-400 4.23e-37

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 141.06  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRAEE-------VAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQA 225
Cdd:cd05049    1 HIKRDTIVLKRELGEGAFGKVFLGECYNLEpeqdkmlVAVKTLKDASSPDARKdfereaelLTNLQHENIVKFYGVCTEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRA----------GRKITPRL----LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA 291
Cdd:cd05049   81 DPLLMVFEYMEHGDLNKFLRShgpdaaflasEDSAPGELtlsqLLHIAVQIASGMVYLASQHFVHRDLATRNCLVGTNLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 292 VKISDFGTSKELSdkSTKMSFAG-----TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVG 365
Cdd:cd05049  161 VKIGDFGMSRDIY--STDYYRVGghtmlPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTyGKQPWFQLSNTEVIECIT 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 366 SNSLhLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05049  239 QGRL-LQRPRTCPSEVYAVMLGCWKREPQQRLNIK 272
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
170-398 6.66e-37

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 140.30  E-value: 6.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRA--EEVAIKKVR----EQNETDIKH----LRKLKH---PNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd06917    6 LELVGRGSYGAVYRGYHVKtgRVVALKVLNldtdDDDVSDIQKevalLSQLKLgqpKNIIKYYGSYLKGPSLWIIMDYCE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS-FAGT 315
Cdd:cd06917   86 GGSIRTLMRAG-PIAERYIAVIMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFGVAASLNQNSSKRStFVGT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlhlpvPSTCPD-GFKILMKQ----TW 389
Cdd:cd06917  165 PYWMAPEVITEgKYYDTKADIWSLGITTYEMATGNPPYSDVDALRAVMLIPKSK-----PPRLEGnGYSPLLKEfvaaCL 239

                 ....*....
gi 755554055 390 QSKPRNRPS 398
Cdd:cd06917  240 DEEPKDRLS 248
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
165-352 8.49e-37

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 140.27  E-value: 8.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFL------GKFRAEEV----AIKKVREQ--NETDIKHlrKLKHPNIIAFKGVC-TQAPCYCII 231
Cdd:cd06620    5 QDLETLKDLGAGNGGSVSKvlhiptGTIMAKKVihidAKSSVRKQilRELQILH--ECHSPYIVSFYGAFlNENNNIIIC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH-LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKM 310
Cdd:cd06620   83 MEYMDCGSLDKILKKKGPFPEEVLGKIAVAVLEGLTYLYnVHRIIHRDIKPSNILVNSKGQIKLCDFGVSGELIN-SIAD 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd06620  162 TFVGTSTYMSPERIQGGKYSVKSDVWSLGLSIIELALGEFPF 203
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
161-407 1.04e-36

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 139.83  E-value: 1.04e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRAE-------EVAIKKVRE----QNETDIKH----LRKLKHPNIIAFKGVCTQA 225
Cdd:cd05036    2 EVPRKNLTLIRALGQGAFGEVYEGTVSGMpgdpsplQVAVKTLPElcseQDEMDFLMealiMSKFNHPNIVRCIGVCFQR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGR-------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKIS 295
Cdd:cd05036   82 LPRFILLELMAGGDLKSFLRENRprpeqpsSLTMLDLLQLAQDVAKGCRYLEENHFIHRDIAARNCLLTCKGPgrvAKIG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 296 DFGTSKEL--SDKSTKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHL 371
Cdd:cd05036  162 DFGMARDIyrADYYRKGGKAMlPVKWMPPEAFLDGIFTSKTDVWSFGVLLWEIFSlGYMPYPGKSNQEVMEFVTSGGRMD 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 372 PvPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05036  242 P-PKNCPGPVYRIMTQCWQHIPEDRPNFSTILERLN 276
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
160-422 1.09e-36

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 140.10  E-value: 1.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLG------KFRAE-EVAIKKVREQ----------NETDIkhLRKLKHPNIIAFKGVC 222
Cdd:cd05061    1 WEVSREKITLLRELGQGSFGMVYEGnardiiKGEAEtRVAVKTVNESaslrerieflNEASV--MKGFTCHHVVRLLGVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQAPCYCIIMEYCAHGQLYEVLRAGR--------KITPRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV 292
Cdd:cd05061   79 SKGQPTLVVMELMAHGDLKSYLRSLRpeaennpgRPPPTLqeMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 293 KISDFGTSKELSDksTKMSFAG-----TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGS 366
Cdd:cd05061  159 KIGDFGMTRDIYE--TDYYRKGgkgllPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSlAEQPYQGLSNEQVLKFVMD 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 367 NSlHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTlmhLDIASADVLATPQETYF 422
Cdd:cd05061  237 GG-YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI---VNLLKDDLHPSFPEVSF 288
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
170-405 1.11e-36

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 138.92  E-value: 1.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLG--KFRAEEVAIKKV--REQNETDIKHLR-------KLKHPNIIAFKGVCTQAPCYCIIMEYcAHG 238
Cdd:cd14002    6 LELIGEGSFGKVYKGrrKYTGQVVALKFIpkRGKSEKELRNLRqeieilrKLNHPNIIEMLDSFETKKEFVVVTEY-AQG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKitprLLVDWSTGIA----SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFA 313
Cdd:cd14002   85 ELFQILEDDGT----LPEEEVRSIAkqlvSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCNTLVLtSIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYkdvdSSAIIWGVGSNSLHLPV--PSTCPDGFKILMKQTWQS 391
Cdd:cd14002  161 GTPLYMAPELVQEQPYDHTADLWSLGCILYELFVGQPPF----YTNSIYQLVQMIVKDPVkwPSNMSPEFKSFLQGLLNK 236
                        250
                 ....*....|....
gi 755554055 392 KPRNRPSFRQTLMH 405
Cdd:cd14002  237 DPSKRLSWPDLLEH 250
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
158-412 1.22e-36

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 139.88  E-value: 1.22e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVpfeeISELqwlGSGAQGAVFL------GKFRAEEVAIKKVREQNE---TDIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd06611    5 DIWEI----IGEL---GDGAFGKVYKaqhketGLFAAAKIIQIESEEELEdfmVEIDILSECKHPNIVGLYEAYFYENKL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYE-VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS-KELSDK 306
Cdd:cd06611   78 WILIEFCDGGALDSiMLELERGLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGVSaKNKSTL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGTVAWMAPEVI-----RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV-GSNSLHLPVPSTCPDG 380
Cdd:cd06611  158 QKRDTFIGTPYWMAPEVVacetfKDNPYDYKADIWSLGITLIELAQMEPPHHELNPMRVLLKIlKSEPPTLDQPSKWSSS 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 755554055 381 FKILMKQTWQSKPRNRPSFRQTLMHLDIASAD 412
Cdd:cd06611  238 FNDFLKSCLVKDPDDRPTAAELLKHPFVSDQS 269
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
173-401 1.24e-36

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 138.60  E-value: 1.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-EVAIKKVREQ--NETDIKHLRKLK------HPNIIAFKGVCTQ-APCYcIIMEYCAHGQLYE 242
Cdd:cd05085    4 LGKGNFGEVYKGTLKDKtPVAVKTCKEDlpQELKIKFLSEARilkqydHPNIVKLIGVCTQrQPIY-IVMELVPGGDFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT--VAWM 319
Cdd:cd05085   83 FLRKKKdELKTKQLVKFSLDAAAGMAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQipIKWT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 320 APEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 398
Cdd:cd05085  163 APEALNYGRYSSESDVWSFGILLWETFSlGVCPYPGMTNQQAREQV-EKGYRMSAPQRCPEDIYKIMQRCWDYNPENRPK 241

                 ...
gi 755554055 399 FRQ 401
Cdd:cd05085  242 FSE 244
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
151-405 1.33e-36

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 139.03  E-value: 1.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 151 DYKLQqqdtwevpfEEIselqwlGSGAQGAVFLGKF--RAEEVAIKKVR-EQNETDIKHLRK-------LKHPNIIAFKG 220
Cdd:cd06610    2 DYELI---------EVI------GSGATAVVYAAYClpKKEKVAIKRIDlEKCQTSMDELRKeiqamsqCNHPNVVSYYT 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 221 VCTQAPCYCIIMEYCAHGQLYEVLRagrKITPRLLVDWSTgIAS-------GMNYLHLHKIIHRDLKSPNVLVTHTDAVK 293
Cdd:cd06610   67 SFVVGDELWLVMPLLSGGSLLDIMK---SSYPRGGLDEAI-IATvlkevlkGLEYLHSNGQIHRDVKAGNILLGEDGSVK 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 294 ISDFGTSKELSD-----KSTKMSFAGTVAWMAPEVIrnEPV---SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWgvg 365
Cdd:cd06610  143 IADFGVSASLATggdrtRKVRKTFVGTPCWMAPEVM--EQVrgyDFKADIWSFGITAIELATGAAPYSKYPPMKVLM--- 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 366 sNSLHLPVPS--TCPDG------FKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06610  218 -LTLQNDPPSleTGADYkkysksFRKMISLCLQKDPSKRPTAEELLKH 264
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
156-399 1.43e-36

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 139.01  E-value: 1.43e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 156 QQDTWEVPFEEISELQWLGSGAQGAVFLGKF-RAEEVAIKKVREQNET------DIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd05073    2 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYnKHTKVAVKTMKPGSMSveaflaEANVMKTLQHDKLVKLHAVVTKEPIY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 cIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd05073   82 -IITEFMAKGSLLDFLKSdeGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 --STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKI 383
Cdd:cd05073  161 eyTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTyGRIPYPGMSNPEVIRAL-ERGYRMPRPENCPEELYN 239
                        250
                 ....*....|....*.
gi 755554055 384 LMKQTWQSKPRNRPSF 399
Cdd:cd05073  240 IMMRCWKNRPEERPTF 255
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
173-405 1.57e-36

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 138.51  E-value: 1.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK---------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14009    1 IGRGSFATVWKGRHKQtgEVVAIKeisrkklnkKLQENLESEIAILKSIKHPNIVRLYDVQKTEDFIYLVLEYCAGGDLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14009   81 QYIRKRGRLPEAVARHFMQQLASGLKFLRSKNIIHRDLKPQNLLLSTSGDdpvLKIADFGFARSLQPASMAETLCGSPLY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKdvdssaiiwgvGSNSLHL--------------PVPSTCPDgFKIL 384
Cdd:cd14009  161 MAPEILQFQKYDAKADLWSVGAILFEMLVGKPPFR-----------GSNHVQLlrniersdavipfpIAAQLSPD-CKDL 228
                        250       260
                 ....*....|....*....|.
gi 755554055 385 MKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14009  229 LRRLLRRDPAERISFEEFFAH 249
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
161-407 1.81e-36

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 138.85  E-value: 1.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELqwLGSGAQGAVFLGKF-----RAEEVAIKKVR----EQNETDI----KHLRKLKHPNIIAFKGVCTQAPC 227
Cdd:cd05065    2 DVSCVKIEEV--IGAGEFGEVCRGRLklpgkREIFVAIKTLKsgytEKQRRDFlseaSIMGQFDHPNIIHLEGVVTKSRP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 YCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd05065   80 VMIITEFMENGALDSFLRQNDgQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGT------VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPD 379
Cdd:cd05065  160 TSDPTYTSSlggkipIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSyGERPYWDMSNQDVINAI-EQDYRLPPPMDCPT 238
                        250       260
                 ....*....|....*....|....*...
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05065  239 ALHQLMLDCWQKDRNLRPKFGQIVNTLD 266
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
166-407 2.25e-36

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 138.64  E-value: 2.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELqwLGSGAQGAVFLGKFRAEeVAIKKVREQNETDiKHL----------RKLKHPNIIAFKGVCTQAPCYCIIMEYC 235
Cdd:cd14063    3 EIKEV--IGKGRFGRVHRGRWHGD-VAIKLLNIDYLNE-EQLeafkeevaayKNTRHDNLVLFMGACMDPPHLAIVTSLC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVkISDFGTSKeLSDKSTKMSFAG 314
Cdd:cd14063   79 KGRTLYSLIHERKeKFDFNKTVQIAQQICQGMGYLHAKGIIHKDLKSKNIFLENGRVV-ITDFGLFS-LSGLLQPGRRED 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVA----W---MAPEVIRN----------EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGS------NSLHL 371
Cdd:cd14063  157 TLVipngWlcyLAPEIIRAlspdldfeesLPFTKASDVYAFGTVWYELLAGRWPFKEQPAESIIWQVGCgkkqslSQLDI 236
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 372 PVpstcpDGFKILMkQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14063  237 GR-----EVKDILM-QCWAYDPEKRPTFSDLLRMLE 266
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
173-403 2.29e-36

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 138.31  E-value: 2.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKV-------REQNET--DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd08529    8 LGKGSFGVVYKVVRKVDGrvYALKQIdisrmsrKMREEAidEARVLSKLNSPYVIKYYDSFVDKGKLNIVMEYAENGDLH 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST-KMSFAGTVAW 318
Cdd:cd08529   88 SLIKSqrGRPLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILSDTTNfAQTIVGTPYY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA----IIWGVgsnslHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd08529  168 LSPELCEDKPYNEKSDVWALGCVLYELCTGKHPFEAQNQGAlilkIVRGK-----YPPISASYSQDLSQLIDSCLTKDYR 242

                 ....*....
gi 755554055 395 NRPSFRQTL 403
Cdd:cd08529  243 QRPDTTELL 251
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
164-405 3.37e-36

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 137.86  E-value: 3.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEEV--AIKKVR------EQNE--TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06605    3 LEYLGEL---GEGNGGVVSKVRHRPSGQimAVKVIRleideaLQKQilRELDVLHKCNSPYIVGFYGAFYSEGDISICME 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH-LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKmSF 312
Cdd:cd06605   80 YMDGGSLDKILKEVGRIPERILGKIAVAVVKGLIYLHeKHKIIHRDVKPSNILVNSRGQVKLCDFGVSGQLVDSLAK-TF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----------SAIiwgVGSNSLHLPVPSTCPDgFK 382
Cdd:cd06605  159 VGTRSYMAPERISGGKYTVKSDIWSLGLSLVELATGRFPYPPPNAkpsmmifellSYI---VDEPPPLLPSGKFSPD-FQ 234
                        250       260
                 ....*....|....*....|...
gi 755554055 383 ILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06605  235 DFVSQCLQKDPTERPSYKELMEH 257
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
182-405 3.42e-36

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 137.70  E-value: 3.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 182 FLGKFRAEEVAIkkvreqnetdikhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTG 261
Cdd:cd14080   44 FLEKFLPRELEI-------------LRKLRHPNIIQVYSIFERGSKVFIFMEYAEHGDLLEYIQKRGALSESQARIWFRQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM---SFAGTVAWMAPEVIRNEPVSEKV-DIWS 337
Cdd:cd14080  111 LALAVQYLHSLDIAHRDLKCENILLDSNNNVKLSDFGFARLCPDDDGDVlskTFCGSAAYAAPEILQGIPYDPKKyDIWS 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755554055 338 FGVVLWELLTGEIPYKDVDSSAIIW-----GVGSNSLHLPVPSTCpdgfKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14080  191 LGVILYIMLCGSMPFDDSNIKKMLKdqqnrKVRFPSSVKKLSPEC----KDLIDQLLEPDPTKRATIEEILNH 259
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
173-405 5.40e-36

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 137.30  E-value: 5.40e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK-----KVREQNET------------DIKH----LRKLKHPNIIAFKGVCT--QAPC 227
Cdd:cd14008    1 LGRGSFGKVKLALDTEtgQLYAIKifnksRLRKRREGkndrgkiknaldDVRReiaiMKKLDHPNIVRLYEVIDdpESDK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 YCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD 305
Cdd:cd14008   81 LYLVLEYCEGGPVMELDSGDRVppLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSEMFED 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSF-AGTVAWMAPEVIRNEPVS---EKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd14008  161 GNDTLQKtAGTPAFLAPELCDGDSKTysgKAADIWALGVTLYCLVFGRLPFNGDNILELYEAIQNQNDEFPIPPELSPEL 240
                        250       260
                 ....*....|....*....|....
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14008  241 KDLLRRMLEKDPEKRITLKEIKEH 264
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
161-407 6.45e-36

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 137.41  E-value: 6.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRAE-----EVAIKKVR----EQNETDIKH----LRKLKHPNIIAFKGVCTQAPC 227
Cdd:cd05063    1 EIHPSHITKQKVIGAGEFGEVFRGILKMPgrkevAVAIKTLKpgytEKQRQDFLSeasiMGQFSHHNIIRLEGVVTKFKP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 YCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD- 305
Cdd:cd05063   81 AMIITEYMENGALDKYLRDHDgEFSSYQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVSDFGLSRVLEDd 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 -KSTKMSFAGTVA--WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGF 381
Cdd:cd05063  161 pEGTYTTSGGKIPirWTAPEAIAYRKFTSASDVWSFGIVMWEVMSfGERPYWDMSNHEVMKAI-NDGFRLPAPMDCPSAV 239
                        250       260
                 ....*....|....*....|....*.
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05063  240 YQLMLQCWQQDRARRPRFVDIVNLLD 265
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
170-398 1.53e-35

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 135.87  E-value: 1.53e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL-------GKFRAEEVAIKKVREQNETDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd08219    5 LRVVGEGSFGRALLvqhvnsdQKYAMKEIRLPKSSSAVEDSRKEavlLAKMKHPNIVAFKESFEADGHLYIVMEYCDGGD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLR--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK-STKMSFAGTV 316
Cdd:cd08219   85 LMQKIKlqRGKLFPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLTSPgAYACTYVGTP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHlPVPSTCPDGFKILMKQTWQSKPRNR 396
Cdd:cd08219  165 YYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGSYK-PLPSHYSYELRSLIKQMFKRNPRSR 243

                 ..
gi 755554055 397 PS 398
Cdd:cd08219  244 PS 245
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
157-399 1.84e-35

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 136.35  E-value: 1.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 157 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVR------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYc 229
Cdd:cd05070    1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNtKVAIKTLKpgtmspESFLEEAQIMKKLKHDKLVQLYAVVSEEPIY- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK- 306
Cdd:cd05070   80 IVTEYMSKGSLLDFLKDGEGRALKLpnLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNe 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 -STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKIL 384
Cdd:cd05070  160 yTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTkGRVPYPGMNNREVLEQV-ERGYRMPCPQDCPISLHEL 238
                        250
                 ....*....|....*
gi 755554055 385 MKQTWQSKPRNRPSF 399
Cdd:cd05070  239 MIHCWKKDPEERPTF 253
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
170-401 2.10e-35

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 136.25  E-value: 2.10e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQW-LGSGAQGAVFLGKFR---AEE----VAIKKVREQNET-------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd05092    9 LKWeLGEGAFGKVFLAECHnllPEQdkmlVAVKALKEATESarqdfqrEAELLTVLQHQHIVRFYGVCTEGEPLIMVFEY 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRA----------------GRKITPRLLvDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG 298
Cdd:cd05092   89 MRHGDLNRFLRShgpdakildggegqapGQLTLGQML-QIASQIASGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 TSKELSdkSTKMSFAG-----TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLP 372
Cdd:cd05092  168 MSRDIY--STDYYRVGgrtmlPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTyGKQPWYQLSNTEAIECI-TQGRELE 244
                        250       260
                 ....*....|....*....|....*....
gi 755554055 373 VPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05092  245 RPRTCPPEVYAIMQGCWQREPQQRHSIKD 273
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
173-399 2.26e-35

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 135.04  E-value: 2.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-EVAIKKVR------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYcIIMEYCAHGQLYEVLR 245
Cdd:cd14203    3 LGQGCFGEVWMGTWNGTtKVAIKTLKpgtmspEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIY-IVTEFMSKGSLLDFLK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMSFAGTVAWMAP 321
Cdd:cd14203   82 DGEGKYLKLpqLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNeyTARQGAKFPIKWTAP 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 322 EVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 399
Cdd:cd14203  162 EAALYGRFTIKSDVWSFGILLTELVTkGRVPYPGMNNREVLEQV-ERGYRMPCPPGCPESLHELMCQCWRKDPEERPTF 239
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
168-403 3.27e-35

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 134.94  E-value: 3.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 168 SELQWLGSGAQGAVFLGKFRAE-------EVAIKK--VREQNET--DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd08218    3 VRIKKIGEGSFGKALLVKSKEDgkqyvikEINISKmsPKEREESrkEVAVLSKMKHPNIVQYQESFEENGNLYIVMDYCD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKMSFA 313
Cdd:cd08218   83 GGDLYKRINAQRGVlfPEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVLnSTVELARTCI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd08218  163 GTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGS-YPPVPSRYSYDLRSLVSQLFKRNP 241
                        250
                 ....*....|
gi 755554055 394 RNRPSFRQTL 403
Cdd:cd08218  242 RDRPSINSIL 251
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
173-405 3.29e-35

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 134.99  E-value: 3.29e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGK--FRAEEVAIK----------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14099    9 LGKGGFAKCYEVTdmSTGKVYAGKvvpkssltkpKQREKLKSEIKIHRSLKHPNIVKFHDCFEDEENVYILLELCSNGSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWM 319
Cdd:cd14099   89 MELLKRRKALTEPEVRYFMRQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAARLeYDGERKKTLCGTPNYI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 320 APEVI-RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 398
Cdd:cd14099  169 APEVLeKKKGHSFEVDIWSLGVILYTLLVGKPPFETSDVKETYKRIKKNEYSFPSHLSISDEAKDLIRSMLQPDPTKRPS 248

                 ....*..
gi 755554055 399 FRQTLMH 405
Cdd:cd14099  249 LDEILSH 255
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
173-407 4.69e-35

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 134.61  E-value: 4.69e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKF-----RAEEVAIKKVR----EQNETDI----KHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd05066   12 IGAGEFGEVCSGRLklpgkREIPVAIKTLKagytEKQRRDFlseaSIMGQFDHPNIIHLEGVVTRSKPVMIVTEYMENGS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD--KSTKMSFAGTV 316
Cdd:cd05066   92 LDAFLRKHDgQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDdpEAAYTTRGGKI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 A--WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd05066  172 PirWTAPEAIAYRKFTSASDVWSYGIVMWEVMSyGERPYWEMSNQDVIKAI-EEGYRLPAPMDCPAALHQLMLDCWQKDR 250
                        250
                 ....*....|....
gi 755554055 394 RNRPSFRQTLMHLD 407
Cdd:cd05066  251 NERPKFEQIVSILD 264
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
173-400 5.27e-35

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 135.06  E-value: 5.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKF------RAEEVAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCI--IMEYCA 236
Cdd:cd05079   12 LGEGHFGKVELCRYdpegdnTGEQVAVKSLKPESggnhiadlKKEIEILRNLYHENIVKYKGICTEDGGNGIklIMEFLP 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVL-RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK----STKMS 311
Cdd:cd05079   92 SGSLKEYLpRNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDkeyyTVKDD 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTgeipYKDVDSSAI------------------IWGVGSNSLHLPV 373
Cdd:cd05079  172 LDSPVFWYAPECLIQSKFYIASDVWSFGVTLYELLT----YCDSESSPMtlflkmigpthgqmtvtrLVRVLEEGKRLPR 247
                        250       260
                 ....*....|....*....|....*..
gi 755554055 374 PSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05079  248 PPNCPEEVYQLMRKCWEFQPSKRTTFQ 274
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
165-405 7.16e-35

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 134.86  E-value: 7.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETDIKH--LRKLK------HPNIIAFKGVCT--QAPCYCIIM 232
Cdd:cd06621    1 DKIVELSSLGEGAGGSVTKCRLRNTKtiFALKTITTDPNPDVQKqiLRELEinkscaSPYIVKYYGAFLdeQDSSIGIAM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQL---Y-EVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkST 308
Cdd:cd06621   81 EYCEGGSLdsiYkKVKKKGGRIGEKVLGKIAESVLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSGELVN-SL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY-KDVDSSAIIWGVGSNSLHLPVPS--TCPDG----- 380
Cdd:cd06621  160 AGTFTGTSYYMAPERIQGGPYSITSDVWSLGLTLLEVAQNRFPFpPEGEPPLGPIELLSYIVNMPNPElkDEPENgikws 239
                        250       260
                 ....*....|....*....|....*..
gi 755554055 381 --FKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06621  240 esFKDFIEKCLEKDGTRRPGPWQMLAH 266
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
160-408 8.42e-35

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 134.39  E-value: 8.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEeVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQAPcYCI 230
Cdd:cd14149    7 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD-VAVKILKVVDPTpeqfqafrnEVAVLRKTRHVNILLFMGYMTKDN-LAI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG--TSKELSDKS 307
Cdd:cd14149   85 VTQWCEGSSLYKHLHVqETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGlaTVKSRWSGS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKM-SFAGTVAWMAPEVIR---NEPVSEKVDIWSFGVVLWELLTGEIPYKDV-DSSAIIWGVGSNSLHLPVP---STCPD 379
Cdd:cd14149  165 QQVeQPTGSILWMAPEVIRmqdNNPFSFQSDVYSYGIVLYELMTGELPYSHInNRDQIIFMVGRGYASPDLSklyKNCPK 244
                        250       260
                 ....*....|....*....|....*....
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLDI 408
Cdd:cd14149  245 AMKRLVADCIKKVKEERPLFPQILSSIEL 273
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
179-406 1.29e-34

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 133.00  E-value: 1.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 179 GAVFLGK-FRAEEVAIKKV---------REQNET--DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-R 245
Cdd:cd14065    2 GKGFFGEvYKVTHRETGKVmvmkelkrfDEQRSFlkEVKLMRRLSHPNILRFIGVCVKDNKLNFITEYVNGGTLEELLkS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVK---ISDFGTSKELSDKSTK-------MSFAGT 315
Cdd:cd14065   82 MDEQLPWSQRVSLAKDIASGMAYLHSKNIIHRDLNSKNCLVREANRGRnavVADFGLAREMPDEKTKkpdrkkrLTVVGS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtGEIPYK-DVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd14065  162 PYWMAPEMLRGESYDEKVDVFSFGIVLCEII-GRVPADpDYLPRTMDFGLDVRAFRTLYVPDCPPSFLPLAIRCCQLDPE 240
                        250
                 ....*....|..
gi 755554055 395 NRPSFRQTLMHL 406
Cdd:cd14065  241 KRPSFVELEHHL 252
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
173-405 1.40e-34

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 132.74  E-value: 1.40e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVR------EQNETDIKHLRKLK----HPNIIAFKGVCTQAPC--YCIIMEYCaHG 238
Cdd:cd05118    7 IGEGAFGTVWLARDKVtgEKVAIKKIKndfrhpKAALREIKLLKHLNdvegHPNIVKLLDVFEHRGGnhLCLVFELM-GM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLR-AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH-TDAVKISDFGTSKELSDKsTKMSFAGTV 316
Cdd:cd05118   86 NLYELIKdYPRGLPLDLIKSYLYQLLQALDFLHSNGIIHRDLKPENILINLeLGQLKLADFGLARSFTSP-PYTPYVATR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEI---PYKDVDssaiiwgvgsnSLHLPVPSTCPDGFKILMKQTWQSK 392
Cdd:cd05118  165 WYRAPEVLLGaKPYGSSIDIWSLGCILAELLTGRPlfpGDSEVD-----------QLAKIVRLLGTPEALDLLSKMLKYD 233
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd05118  234 PAKRITASQALAH 246
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
166-401 1.52e-34

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 134.76  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE------EVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYcII 231
Cdd:cd05108    8 EFKKIKVLGSGAFGTVYKGLWIPEgekvkiPVAIKELREATSPKANKeildeayvMASVDNPHVCRLLGICLTSTVQ-LI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTK 309
Cdd:cd05108   87 TQLMPFGCLLDYVREHKdNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLgAEEKEY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 MSFAGTV--AWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIwGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd05108  167 HAEGGKVpiKWMALESILHRIYTHQSDVWSYGVTVWELMTfGSKPYDGIPASEIS-SILEKGERLPQPPICTIDVYMIMV 245
                        250
                 ....*....|....*
gi 755554055 387 QTWQSKPRNRPSFRQ 401
Cdd:cd05108  246 KCWMIDADSRPKFRE 260
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
169-405 1.55e-34

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 132.90  E-value: 1.55e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd08530    4 VLKKLGKGSYGSVYKVKRLSdnQVYALKEVNLGSLSQkeredsvneIRLLASVNHPNIIRYKEAFLDGNRLCIVMEYAPF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKiTPRLLVD---WST--GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF 312
Cdd:cd08530   84 GDLSKLISKRKK-KRRLFPEddiWRIfiQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKVLKKNLAKTQI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 aGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHlPVPSTCPDGFKILMKQTWQSK 392
Cdd:cd08530  163 -GTPLYAAPEVWKGRPYDYKSDIWSLGCLLYEMATFRPPFEARTMQELRYKVCRGKFP-PIPPVYSQDLQQIIRSLLQVN 240
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd08530  241 PKKRPSCDKLLQS 253
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
157-399 1.93e-34

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 133.27  E-value: 1.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 157 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVR------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYc 229
Cdd:cd05069    4 KDAWEIPRESLRLDVKLGQGCFGEVWMGTWNGTtKVAIKTLKpgtmmpEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIY- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK- 306
Cdd:cd05069   83 IVTEFMGKGSLLDFLKEGDGKYLKLpqLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNe 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 -STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKIL 384
Cdd:cd05069  163 yTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTkGRVPYPGMVNREVLEQV-ERGYRMPCPQGCPESLHEL 241
                        250
                 ....*....|....*
gi 755554055 385 MKQTWQSKPRNRPSF 399
Cdd:cd05069  242 MKLCWKKDPDERPTF 256
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
173-406 1.94e-34

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 132.93  E-value: 1.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--------EVAIKKVR------EQNE--TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd05044    3 LGSGAFGEVFEGTAKDIlgdgsgetKVAVKTLRkgatdqEKAEflKEAHLMSNFKHPNILKLLGVCLDNDPQYIILELME 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKIT---PRL----LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD----AVKISDFGTSKEL-- 303
Cdd:cd05044   83 GGDLLSYLRAARPTAftpPLLtlkdLLSICVDVAKGCVYLEDMHFVHRDLAARNCLVSSKDyrerVVKIGDFGLARDIyk 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 SDKSTKmsfAGT----VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSlHLPVPSTCP 378
Cdd:cd05044  163 NDYYRK---EGEgllpVRWMAPESLVDGVFTTQSDVWAFGVLMWEILTlGQQPYPARNNLEVLHFVRAGG-RLDQPDNCP 238
                        250       260
                 ....*....|....*....|....*...
gi 755554055 379 DGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05044  239 DDLYELMLRCWSTDPEERPSFARILEQL 266
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
173-405 2.16e-34

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 132.35  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVA-----IKKVREQNETDIKH----LRKLKHPNIIAFKG--VCTQAPCYCIIMEYCAHGQ 239
Cdd:cd13983    9 LGRGSFKTVYRAfdTEEGIEVAwneikLRKLPKAERQRFKQeieiLKSLKHPNIIKFYDswESKSKKEVIFITELMTSGT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVT-HTDAVKISDFGTSKELsDKSTKMSFAGTV 316
Cdd:cd13983   89 LKQYLKRFKRLKLKVIKSWCRQILEGLNYLHTRDppIIHRDLKCDNIFINgNTGEVKIGDLGLATLL-RQSFAKSVIGTP 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIrNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW-----GVGSNSLHLpVPStcPDGFKILMKQTwqS 391
Cdd:cd13983  168 EFMAPEMY-EEHYDEKVDIYAFGMCLLEMATGEYPYSECTNAAQIYkkvtsGIKPESLSK-VKD--PELKDFIEKCL--K 241
                        250
                 ....*....|....
gi 755554055 392 KPRNRPSFRQTLMH 405
Cdd:cd13983  242 PPDERPSARELLEH 255
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
167-399 2.16e-34

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 132.76  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQwLGSGAQGAVFLGKFRAE----EVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCtQAPCYCIIMEY 234
Cdd:cd05115    7 IDEVE-LGSGNFGCVKKGVYKMRkkqiDVAIKVLKQGNEKAVRDemmreaqiMHQLDNPYIVRMIGVC-EAEALMLVMEM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS--DKSTKMS 311
Cdd:cd05115   85 ASGGPLNKFLSGKKdEITVSNVVELMHQVSMGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGadDSYYKAR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGT--VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDGFKILMKQT 388
Cdd:cd05115  165 SAGKwpLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSyGQKPYKKMKGPEVMSFIEQGK-RMDCPAECPPEMYALMSDC 243
                        250
                 ....*....|.
gi 755554055 389 WQSKPRNRPSF 399
Cdd:cd05115  244 WIYKWEDRPNF 254
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
160-405 2.34e-34

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 132.92  E-value: 2.34e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEV--AIKKVREQNETDIKHL-------RKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd06624    3 YEYEYDESGERVVLGKGTFGVVYAARDLSTQVriAIKEIPERDSREVQPLheeialhSRLSHKNIVQYLGSVSEDGFFKI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRAgrKITPrlLVD-------WSTGIASGMNYLHLHKIIHRDLKSPNVLV-THTDAVKISDFGTSKE 302
Cdd:cd06624   83 FMEQVPGGSLSALLRS--KWGP--LKDnentigyYTKQILEGLKYLHDNKIVHRDIKGDNVLVnTYSGVVKISDFGTSKR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 303 LS--DKSTKmSFAGTVAWMAPEVIRNEP--VSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLHLPVPSTC 377
Cdd:cd06624  159 LAgiNPCTE-TFTGTLQYMAPEVIDKGQrgYGPPADIWSLGCTIIEMATGKPPFIELGEpQAAMFKVGMFKIHPEIPESL 237
                        250       260
                 ....*....|....*....|....*...
gi 755554055 378 PDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06624  238 SEEAKSFILRCFEPDPDKRATASDLLQD 265
PTKc_EphR_A10 cd05064
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the ...
207-401 2.93e-34

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphA10, which contains an inactive tyr kinase domain, may function to attenuate signals of co-clustered active receptors. EphA10 is mainly expressed in the testis. Ephrin/EphR interaction results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). In general, class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The EphA10 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133195 [Multi-domain]  Cd Length: 266  Bit Score: 132.35  E-value: 2.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 285
Cdd:cd05064   60 LGQFDHSNIVRLEGVITRGNTMMIVTEYMSNGALDSFLRKHEgQLVAGQLMGMLPGLASGMKYLSEMGYVHKGLAAHKVL 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 286 VTHTDAVKISDFGTSKElsDKS----TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAI 360
Cdd:cd05064  140 VNSDLVCKISGFRRLQE--DKSeaiyTTMSGKSPVLWAAPEAIQYHHFSSASDVWSFGIVMWEVMSyGERPYWDMSGQDV 217
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755554055 361 IWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05064  218 IKAV-EDGFRLPAPRNCPNLLHQLMLDCWQKERGERPRFSQ 257
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
170-403 3.27e-34

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 132.00  E-value: 3.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL--GKFRAEEVAIKKV---------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd08225    5 IKKIGEGSFGKIYLakAKSDSEHCVIKEIdltkmpvkeKEASKKEVILLAKMKHPNIVTFFASFQENGRLFIVMEYCDGG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDkSTKMSF--A 313
Cdd:cd08225   85 DLMKRINRQRGVlfSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNGMVaKLGDFGIARQLND-SMELAYtcV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKdvdssaiiwgvgSNSLHLPVPSTCPDGF-----------K 382
Cdd:cd08225  164 GTPYYLSPEICQNRPYNNKTDIWSLGCVLYELCTLKHPFE------------GNNLHQLVLKICQGYFapispnfsrdlR 231
                        250       260
                 ....*....|....*....|.
gi 755554055 383 ILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd08225  232 SLISQLFKVSPRDRPSITSIL 252
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
173-352 4.63e-34

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 132.57  E-value: 4.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQNETDIKH----------LRKLKHPNIIAFKGV--------CTQAPCYCiiM 232
Cdd:cd13989    1 LGSGGFGYVTLWKHQdtGEYVAIKKCRQELSPSDKNrerwclevqiMKKLNHPNVVSARDVppeleklsPNDLPLLA--M 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLR-----AGRKITP--RLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKE 302
Cdd:cd13989   79 EYCSGGDLRKVLNqpencCGLKESEvrTLLSD----ISSAISYLHENRIIHRDLKPENIVLQQGGGrviYKLIDLGYAKE 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 303 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd13989  155 LDQGSLCTSFVGTLQYLAPELFESKKYTCTVDYWSFGTLAFECITGYRPF 204
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
173-413 8.29e-34

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 131.28  E-value: 8.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE----VAIKKV------REQNETDIKH---LRKLKHPNIIAFKGVCTQA------PCYCIIME 233
Cdd:cd05075    8 LGEGEFGSVMEGQLNQDDsvlkVAVKTMkiaictRSEMEDFLSEavcMKEFDHPNVMRLIGVCLQNtesegyPSPVVILP 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGR------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD-- 305
Cdd:cd05075   88 FMKHGDLHSFLLYSRlgdcpvYLPTQMLVKFMTDIASGMEYLSSKNFIHRDLAARNCMLNENMNVCVADFGLSKKIYNgd 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 -----KSTKMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAiIWGVGSNSLHLPVPSTCPD 379
Cdd:cd05075  168 yyrqgRISKMP----VKWIAIESLADRVYTTKSDVWSFGVTMWEIATrGQTPYPGVENSE-IYDYLRQGNRLKQPPDCLD 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLDIASADV 413
Cdd:cd05075  243 GLYELMSSCWLLNPKDRPSFETLRCELEKILKDL 276
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
173-405 8.81e-34

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 131.03  E-value: 8.81e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKV--------------REQNET--DIKHLRK------LKHPNIIAFKGVCTQAPCY 228
Cdd:cd14077    9 IGAGSMGKVKLAKHIrtGEKCAIKIIprasnaglkkerekRLEKEIsrDIRTIREaalsslLNHPHICRLRDFLRTPNHY 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd14077   89 YMLFEYVDGGQLLDYIISHGKLKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGLSNLYDPRRL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLpvPSTCPDGFKILMKQ 387
Cdd:cd14077  169 LRTFCGSLYFAAPELLQAQPyTGPEVDVWSFGVVLYVLVCGKVPFDDENMPALHAKIKKGKVEY--PSYLSSECKSLISR 246
                        250
                 ....*....|....*...
gi 755554055 388 TWQSKPRNRPSFRQTLMH 405
Cdd:cd14077  247 MLVVDPKKRATLEQVLNH 264
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
157-399 1.06e-33

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 131.35  E-value: 1.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 157 QDTWEVPFEEISELQWLGSGAQGAVFLGKFRAE-EVAIKKVR------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYc 229
Cdd:cd05071    1 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTtRVAIKTLKpgtmspEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRAGRKITPRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK- 306
Cdd:cd05071   80 IVTEYMSKGSLLDFLKGEMGKYLRLpqLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNe 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 -STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKIL 384
Cdd:cd05071  160 yTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTkGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDL 238
                        250
                 ....*....|....*
gi 755554055 385 MKQTWQSKPRNRPSF 399
Cdd:cd05071  239 MCQCWRKEPEERPTF 253
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
163-405 1.28e-33

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 132.08  E-value: 1.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGK--FRAEEVAIKKV----REQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd06633   19 PEEIFVDLHEIGHGSFGAVYFATnsHTNEVVAIKKMsysgKQTNEKwqdiikEVKFLQQLKHPNTIEYKGCYLKDHTAWL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAhGQLYEVLRAGRKITPRLLVDWST-GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSkelSDKSTK 309
Cdd:cd06633   99 VMEYCL-GSASDLLEVHKKPLQEVEIAAIThGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSA---SIASPA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 MSFAGTVAWMAPEVI--RNEPVSE-KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd06633  175 NSFVGTPYWMAPEVIlaMDEGQYDgKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRGFVD 254
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd06633  255 YCLQKIPQERPSSAELLRH 273
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
170-405 1.37e-33

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 130.63  E-value: 1.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQW-----LGSGAQGAVFLG-KFRAEEVAIKKV---------------REQNETDIkhLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd06631    1 IQWkkgnvLGKGAYGTVYCGlTSTGQLIAVKQVeldtsdkekaekeyeKLQEEVDL--LKTLKHVNIVGYLGTCLEDNVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd06631   79 SIFMEFVPGGSIASILARFGALEEPVFCRYTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAKRLCINLS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KM-------SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlhLPVPSTcPDGF 381
Cdd:cd06631  159 SGsqsqllkSMRGTPYWMAPEVINETGHGRKSDIWSIGCTVFEMATGKPPWADMNPMAAIFAIGSGR--KPVPRL-PDKF 235
                        250       260
                 ....*....|....*....|....*...
gi 755554055 382 ----KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06631  236 speaRDFVHACLTRDQDERPSAEQLLKH 263
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
173-399 1.44e-33

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 130.08  E-value: 1.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR----AEEVAIKKVR-EQNETDIKH--------LRKLKHPNIIAFKGVCtQAPCYCIIMEYCAHGQ 239
Cdd:cd05116    3 LGSGNFGTVKKGYYQmkkvVKTVAVKILKnEANDPALKDellreanvMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---- 315
Cdd:cd05116   82 LNKFLQKNRHVTEKNITELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHgkwp 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd05116  162 VKWYAPECMNYYKFSSKSDVWSFGVLMWEAFSyGQKPYKGMKGNEVTQMI-EKGERMECPAGCPPEMYDLMKLCWTYDVD 240

                 ....*
gi 755554055 395 NRPSF 399
Cdd:cd05116  241 ERPGF 245
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
161-400 1.65e-33

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 130.91  E-value: 1.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKF-------RAEEVAIKKVREQNE----TDIKH---LR-KLKHPNIIAFKGVCTQA 225
Cdd:cd05091    2 EINLSAVRFMEELGEDRFGKVYKGHLfgtapgeQTQAVAIKTLKDKAEgplrEEFRHeamLRsRLQHPNIVCLLGVVTKE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYE--VLRAGRK--------------ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT 289
Cdd:cd05091   82 QPMSMIFSYCSHGDLHEflVMRSPHSdvgstdddktvkstLEPADFLHIVTQIAAGMEYLSSHHVVHKDLATRNVLVFDK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 290 DAVKISDFGTSKEL--SDKSTKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVg 365
Cdd:cd05091  162 LNVKISDLGLFREVyaADYYKLMGNSLlPIRWMSPEAIMYGKFSIDSDIWSYGVVLWEVFSyGLQPYCGYSNQDVIEMI- 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 366 SNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05091  241 RNRQVLPCPDDCPAWVYTLMLECWNEFPSRRPRFK 275
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
171-405 2.52e-33

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 129.37  E-value: 2.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGKFR--AEEVAIKKVREQNET--DIKHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd14069    7 QTLGEGAFGEVFLAVNRntEEAVAVKFVDMKRAPgdCPENIKKevciqkmLSHKNVVRFYGHRREGEFQYLFLEYASGGE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEvlragrKITPRLLVD------WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK---M 310
Cdd:cd14069   87 LFD------KIEPDVGMPedvaqfYFQQLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGLATVFRYKGKErllN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPY---KDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd14069  161 KMCGTLPYVAPELLAKKKYrAEPVDVWSCGIVLFAMLAGELPWdqpSDSCQEYSDWKENKKTYLTPWKKIDTAALSLLRK 240
                        250
                 ....*....|....*....
gi 755554055 387 qTWQSKPRNRPSFRQTLMH 405
Cdd:cd14069  241 -ILTENPNKRITIEDIKKH 258
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
203-408 2.59e-33

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 129.18  E-value: 2.59e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 203 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL-RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKS 281
Cdd:cd14156   38 EISLLQKLSHPNIVRYLGICVKDEKLHPILEYVSGGCLEELLaREELPLSWREKVELACDISRGMVYLHSKNIYHRDLNS 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 282 PNVLVTHTDAVK---ISDFGTSKEL-----SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtGEIPYK 353
Cdd:cd14156  118 KNCLIRVTPRGReavVTDFGLAREVgempaNDPERKLSLVGSAFWMAPEMLRGEPYDRKVDVFSFGIVLCEIL-ARIPAD 196
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 354 -DVDSSAIIWGVGSNSLHLPVPStCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDI 408
Cdd:cd14156  197 pEVLPRTGDFGLDVQAFKEMVPG-CPEPFLDLAASCCRMDAFKRPSFAELLDELED 251
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
161-400 2.66e-33

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 130.13  E-value: 2.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKF------RAEEVAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAP 226
Cdd:cd05090    1 ELPLSAVRFMEELGECAFGKIYKGHLylpgmdHAQLVAIKTLKDYNNPqqwnefqqEASLMTELHHPNIVCLLGVVTQEQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVL-----------RAGRKITPRLLVD------WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT 289
Cdd:cd05090   81 PVCMLFEFMNQGDLHEFLimrsphsdvgcSSDEDGTVKSSLDhgdflhIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 290 DAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVG 365
Cdd:cd05090  161 LHVKISDLGLSREIYSSDYYRVQNKSllpIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSfGLQPYYGFSNQEVIEMVR 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 366 SNSLhLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05090  241 KRQL-LPCSEDCPPRMYSLMTECWQEIPSRRPRFK 274
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
160-421 3.27e-33

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 131.30  E-value: 3.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKF---------RAEEVAIKKVREqNETDiKHLRKL-----------KHPNIIAFK 219
Cdd:cd05100    7 WELSRTRLTLGKPLGEGCFGQVVMAEAigidkdkpnKPVTVAVKMLKD-DATD-KDLSDLvsememmkmigKHKNIINLL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 220 GVCTQ-APCYcIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSP 282
Cdd:cd05100   85 GACTQdGPLY-VLVEYASKGNLREYLRARRppgmdysfdtcklpeeQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 283 NVLVTHTDAVKISDFGTSKELSD-----KSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVD 356
Cdd:cd05100  164 NVLVTEDNVMKIADFGLARDVHNidyykKTTNGRLP--VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTlGGSPYPGIP 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554055 357 SSAiIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD----IASADV---LATPQETY 421
Cdd:cd05100  242 VEE-LFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDrvltVTSTDEyldLSVPFEQY 312
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
173-401 3.43e-33

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 129.13  E-value: 3.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-----VAIKKVREQneTDIKH----------LRKLKHPNIIAFKGVCTQ---APCycIIMEY 234
Cdd:cd05058    3 IGKGHFGCVYHGTLIDSDgqkihCAVKSLNRI--TDIEEveqflkegiiMKDFSHPNVLSLLGICLPsegSPL--VVLPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKS-----T 308
Cdd:cd05058   79 MKHGDLRNFIRSeTHNPTVKDLIGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARDIYDKEyysvhN 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIiwgvgSNSL----HLPVPSTCPDGFKI 383
Cdd:cd05058  159 HTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTrGAPPYPDVDSFDI-----TVYLlqgrRLLQPEYCPDPLYE 233
                        250
                 ....*....|....*...
gi 755554055 384 LMKQTWQSKPRNRPSFRQ 401
Cdd:cd05058  234 VMLSCWHPKPEMRPTFSE 251
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
161-399 5.12e-33

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 129.57  E-value: 5.12e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVF----LGKFRAEE---VAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQA 225
Cdd:cd05050    1 EYPRNNIEYVRDIGQGAFGRVFqaraPGLLPYEPftmVAVKMLKEEASADMQAdfqreaalMAEFDHPNIVKLLGVCAVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRA---------------GRKITPR-------LLVDWSTGIASGMNYLHLHKIIHRDLKSPN 283
Cdd:cd05050   81 KPMCLLFEYMAYGDLNEFLRHrspraqcslshstssARKCGLNplplsctEQLCIAKQVAAGMAYLSERKFVHRDLATRN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 284 VLVTHTDAVKISDFGTSKEL-SDKSTKMSF--AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSA 359
Cdd:cd05050  161 CLVGENMVVKIADFGLSRNIySADYYKASEndAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSyGMQPYYGMAHEE 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755554055 360 IIWGVGSNSLhLPVPSTCPDGFKILMKQTWQSKPRNRPSF 399
Cdd:cd05050  241 VIYYVRDGNV-LSCPDNCPLELYNLMRLCWSKLPSDRPSF 279
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
173-400 5.20e-33

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 129.70  E-value: 5.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG-----KFRA--EEVAIKKVREQNE--------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd05045    8 LGEGEFGKVVKAtafrlKGRAgyTTVAVKMLKENASsselrdllSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITP------------------------RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVK 293
Cdd:cd05045   88 GSLRSFLRESRKVGPsylgsdgnrnssyldnpderaltmGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMK 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 294 ISDFGTSKEL--SDKSTKMSFAGT-VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVdSSAIIWGVGSNSL 369
Cdd:cd05045  168 ISDFGLSRDVyeEDSYVKRSKGRIpVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTlGGNPYPGI-APERLFNLLKTGY 246
                        250       260       270
                 ....*....|....*....|....*....|.
gi 755554055 370 HLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05045  247 RMERPENCSEEMYNLMLTCWKQEPDKRPTFA 277
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
173-407 7.31e-33

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 128.42  E-value: 7.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-----VAIK--KVREQNETDIKH-------LRKLKHPNIIAFKGVCTQA------PCYCIIM 232
Cdd:cd05035    7 LGEGEFGSVMEAQLKQDDgsqlkVAVKtmKVDIHTYSEIEEflseaacMKDFDHPNVMRLIGVCFTAsdlnkpPSPMVIL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGR------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd05035   87 PFMKHGDLHSYLLYSRlgglpeKLPLQTLLKFMVDIAKGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSRKIYSG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 S-------TKMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAiIWGVGSNSLHLPVPSTCP 378
Cdd:cd05035  167 DyyrqgriSKMP----VKWIALESLADNVYTSKSDVWSFGVTMWEIATrGQTPYPGVENHE-IYDYLRNGNRLKQPEDCL 241
                        250       260
                 ....*....|....*....|....*....
gi 755554055 379 DGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05035  242 DEVYFLMYFCWTVDPKDRPTFTKLREVLE 270
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
173-417 8.88e-33

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 127.92  E-value: 8.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA----------EEVAIKKVREqNET-----DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd08222    8 LGSGNFGTVYLVSDLKatadeelkvlKEISVGELQP-DETvdanrEAKLLSKLDHPAIVKFHDSFVEKESFCIVTEYCEG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRA----GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHtDAVKISDFGTSKEL---SDKSTkm 310
Cdd:cd08222   87 GDLDDKISEykksGTTIDENQILDWFIQLLLAVQYMHERRILHRDLKAKNIFLKN-NVIKVGDFGISRILmgtSDLAT-- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlhLP-VPSTCPDGFKILMKQTW 389
Cdd:cd08222  164 TFTGTPYYMSPEVLKHEGYNSKSDIWSLGCILYEMCCLKHAFDGQNLLSVMYKIVEGE--TPsLPDKYSKELNAIYSRML 241
                        250       260
                 ....*....|....*....|....*...
gi 755554055 390 QSKPRNRPSfrqtlmhldiaSADVLATP 417
Cdd:cd08222  242 NKDPALRPS-----------AAEILKIP 258
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
164-405 1.04e-32

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 127.81  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRA--EEVAIK--KVRE-------QNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06613    2 YELIQRI---GSGTYGDVYKARNIAtgELAAVKviKLEPgddfeiiQQEISM--LKECRHPNIVAYFGSYLRRDKLWIVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-MS 311
Cdd:cd06613   77 EYCGGGSLQDIYQVTGPLSELQIAYVCRETLKGLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQLTATIAKrKS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL---HLPVPSTCPDGFKILM 385
Cdd:cd06613  157 FIGTPYWMAPEVAaveRKGGYDGKCDIWALGITAIELAELQPPMFDLHPMRALFLIPKSNFdppKLKDKEKWSPDFHDFI 236
                        250       260
                 ....*....|....*....|
gi 755554055 386 KQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06613  237 KKCLTKNPKKRPTATKLLQH 256
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
189-352 1.62e-32

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 133.77  E-value: 1.62e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 189 EEVAIKKVREQNETD---IKHLR-------KLKHPNIIAFKGVCTQAPCYCIIMEYCAhGQ-LYEVLRAGRKITPRLLVD 257
Cdd:NF033483  33 RDVAVKVLRPDLARDpefVARFRreaqsaaSLSHPNIVSVYDVGEDGGIPYIVMEYVD-GRtLKDYIREHGPLSPEEAVE 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA--GTVAWMAPEVIRNEPVSEKVDI 335
Cdd:NF033483 112 IMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTDFGIARALSSTTMTQTNSvlGTVHYLSPEQARGGTVDARSDI 191
                        170
                 ....*....|....*..
gi 755554055 336 WSFGVVLWELLTGEIPY 352
Cdd:NF033483 192 YSLGIVLYEMLTGRPPF 208
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
173-405 2.10e-32

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 127.12  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVREQN---------------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYC 235
Cdd:cd14084   14 LGSGACGEVKLAydKSTCKKVAIKIINKRKftigsrreinkprniETEIEILKKLSHPCIIKIEDFFDAEDDYYIVLELM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKMSF 312
Cdd:cd14084   94 EGGELFDRVVSNKRLKEAICKLYFYQMLLAVKYLHSNGIIHRDLKPENVLLSSQEEeclIKITDFGLSKILGETSLMKTL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRN---EPVSEKVDIWSFGVVLWELLTGEIPY----------KDVDSSAIIWGVGSNSlHLPVPStcpd 379
Cdd:cd14084  174 CGTPTYLAPEVLRSfgtEGYTRAVDCWSLGVILFICLSGYPPFseeytqmslkEQILSGKYTFIPKAWK-NVSEEA---- 248
                        250       260
                 ....*....|....*....|....*.
gi 755554055 380 gfKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14084  249 --KDLVKKMLVVDPSRRPSIEEALEH 272
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
173-405 2.63e-32

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 126.82  E-value: 2.63e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL------GKFRAEEVAIK-KVREQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd14098    8 LGSGTFAEVKKavevetGKMRAIKQIVKrKVAGNDKNlqlfqrEINILKSLEHPGIVRLIDWYEDDQHIYLVMEYVEGGD 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKSTKMSFAGTVA 317
Cdd:cd14098   88 LMDFIMAWGAIPEQHARELTKQILEAMAYTHSMGITHRDLKPENILITQDDPviVKISDFGLAKVIHTGTFLVTFCGTMA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNEPVSE------KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPvpstcPD-GFKI------L 384
Cdd:cd14098  168 YLAPEILMSKEQNLqggysnLVDMWSVGCLVYVMLTGALPFDGSSQLPVEKRIRKGRYTQP-----PLvDFNIseeaidF 242
                        250       260
                 ....*....|....*....|.
gi 755554055 385 MKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14098  243 ILRLLDVDPEKRMTAAQALDH 263
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
164-407 2.75e-32

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 127.32  E-value: 2.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEE--ISELQWLGSGAQGAVFL------GKFRAEEVAIKKVREQN-------ETDIKHLRKLKHPNIIAFKGVCTQA--P 226
Cdd:cd05081    1 FEErhLKYISQLGKGNFGSVELcrydplGDNTGALVAVKQLQHSGpdqqrdfQREIQILKALHSDFIVKYRGVSYGPgrR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-S 304
Cdd:cd05081   81 SLRLVMEYLPSGCLRDFLQRHRaRLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLpL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 305 DKS---TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT---------GEI-----PYKDVDSSAIIWGVGSN 367
Cdd:cd05081  161 DKDyyvVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTycdkscspsAEFlrmmgCERDVPALCRLLELLEE 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755554055 368 SLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05081  241 GQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 280
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
170-405 2.86e-32

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 126.40  E-value: 2.86e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAE--EVAIKKVREQN---------ETDIKHLRKLKHPNIIAFKGVCTQAPCYC-IIMEYCAH 237
Cdd:cd08223    5 LRVIGKGSYGEVWLVRHKRDrkQYVIKKLNLKNaskrerkaaEQEAKLLSKLKHPNIVSYKESFEGEDGFLyIVMGFCEG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS-FAG 314
Cdd:cd08223   85 GDLYTRLKEqkGVLLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARVLESSSDMATtLIG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHlPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd08223  165 TPYYMSPELFSNKPYNHKSDVWALGCCVYEMATLKHAFNAKDMNSLVYKILEGKLP-PMPKQYSPELGELIKAMLHQDPE 243
                        250
                 ....*....|.
gi 755554055 395 NRPSFRQTLMH 405
Cdd:cd08223  244 KRPSVKRILRQ 254
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
170-352 5.68e-32

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 125.19  E-value: 5.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRA--EEVAIKKVRE---QNETDIKHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd14073    6 LETLGKGTYGKVKLAIERAtgREVAIKSIKKdkiEDEQDMVRIRReieimssLNHPHIIRIYEVFENKDKIVIVMEYASG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA 317
Cdd:cd14073   86 GELYDYISERRRLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGLSNLYSKDKLLQTFCGSPL 165
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 318 WMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14073  166 YASPEIVNGTPyQGPEVDCWSLGVLLYTLVYGTMPF 201
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
173-349 7.00e-32

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 126.06  E-value: 7.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHgQLY 241
Cdd:cd07829    7 LGEGTYGVVYKAKDKKtgEIVALKKIRLDNEEEgipstalreISLLKELKHPNIVKLLDVIHTENKLYLVFEYCDQ-DLK 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVL-RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSfaGTVA--W 318
Cdd:cd07829   86 KYLdKRPGPLPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARAFGIPLRTYT--HEVVtlW 163
                        170       180       190
                 ....*....|....*....|....*....|...
gi 755554055 319 M-APEVIRNEPV-SEKVDIWSFGVVLWELLTGE 349
Cdd:cd07829  164 YrAPEILLGSKHySTAVDIWSVGCIFAELITGK 196
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
181-401 8.43e-32

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 125.20  E-value: 8.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 181 VFLGKFRAEEVAIKKV---REQNETD---IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRagRKITPrl 254
Cdd:cd13992   18 KKVGVYGGRTVAIKHItfsRTEKRTIlqeLNQLKELVHDNLNKFIGICINPPNIAVVTEYCTRGSLQDVLL--NREIK-- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 lVDWS------TGIASGMNYLHLHKII-HRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSFAGTVA-----WMAPE 322
Cdd:cd13992   94 -MDWMfkssfiKDIVKGMNYLHSSSIGyHGRLKSSNCLVDSRWVVKLTDFGLRNLLEE-QTNHQLDEDAQhkkllWTAPE 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 323 VIRNEPV----SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPS------TCPDGFKILMKQTWQSK 392
Cdd:cd13992  172 LLRGSLLevrgTQKGDVYSFAIILYEILFRSDPFALEREVAIVEKVISGGNKPFRPElavlldEFPPRLVLLVKQCWAEN 251

                 ....*....
gi 755554055 393 PRNRPSFRQ 401
Cdd:cd13992  252 PEKRPSFKQ 260
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
173-407 1.31e-31

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 124.77  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE----EVAIKKVREQNETD--------IKHLRKL-KHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd05047    3 IGEGNFGQVLKARIKKDglrmDAAIKRMKEYASKDdhrdfageLEVLCKLgHHPNIINLLGACEHRGYLYLAIEYAPHGN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-- 301
Cdd:cd05047   83 LLDFLRKSRvletdpafaianstasTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRgq 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSDKSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVdSSAIIWGVGSNSLHLPVPSTCPDG 380
Cdd:cd05047  163 EVYVKKTMGRLP--VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSlGGTPYCGM-TCAELYEKLPQGYRLEKPLNCDDE 239
                        250       260
                 ....*....|....*....|....*..
gi 755554055 381 FKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05047  240 VYDLMRQCWREKPYERPSFAQILVSLN 266
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
174-350 2.05e-31

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 124.92  E-value: 2.05e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQGAVFLGKFRA--EEVAIKKV----REQN-ETDIkhLRKLKHPNIIAFK------GVCTQAPCYCIIMEYCAhGQL 240
Cdd:cd14137   13 GSGSFGVVYQAKLLEtgEVVAIKKVlqdkRYKNrELQI--MRRLKHPNIVKLKyffyssGEKKDEVYLNLVMEYMP-ETL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLR----AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd14137   90 YRVIRhyskNKQTIPIIYVKLYSYQLFRGLAYLHSLGICHRDIKPQNLLVDPETGVlKLCDFGSAKRLVPGEPNVSYICS 169
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 316 VAWMAPEVI-RNEPVSEKVDIWSFGVVLWELLTGEI 350
Cdd:cd14137  170 RYYRAPELIfGATDYTTAIDIWSAGCVLAELLLGQP 205
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
164-403 2.34e-31

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 124.33  E-value: 2.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFL--GKFRAEEVAIKKVREQNETD--------IKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd13996    8 FEEIELL---GSGGFGSVYKvrNKVDGVTYAIKKIRLTEKSSasekvlreVKALAKLNHPNIVRYYTAWVEEPPLYIQME 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRL-LVDWS--TGIASGMNYLHLHKIIHRDLKSPNVLVTHTD-AVKISDFGTSKELSDK--- 306
Cdd:cd13996   85 LCEGGTLRDWIDRRNSSSKNDrKLALElfKQILKGVSYIHSKGIVHRDLKPSNIFLDNDDlQVKIGDFGLATSIGNQkre 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 ------------STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtgeIPYKDVDSSAIIWgvgSNSLHLPVP 374
Cdd:cd13996  165 lnnlnnnnngntSNNSVGIGTPLYASPEQLDGENYNEKADIYSLGIILFEML---HPFKTAMERSTIL---TDLRNGILP 238
                        250       260       270
                 ....*....|....*....|....*....|..
gi 755554055 375 STCPDGF---KILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd13996  239 ESFKAKHpkeADLIQSLLSKNPEERPSAEQLL 270
PK_GC-A_B cd14042
Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The ...
183-406 3.73e-31

Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-A binds and is activated by the atrial and B-type natriuretic peptides, ANP and BNP, which are important in blood pressure regulation and cardiac pathophysiology. GC-B binds the C-type natriuretic peptide, CNP, which is a potent vasorelaxant and functions in vascular remodeling and bone growth regulation. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-A/B subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270944 [Multi-domain]  Cd Length: 279  Bit Score: 123.86  E-value: 3.73e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 183 LGKFRAEEVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRaGRKITprll 255
Cdd:cd14042   25 TGYYKGNLVAIKKVNKKRIdltrevlKELKHMRDLQHDNLTRFIGACVDPPNICILTEYCPKGSLQDILE-NEDIK---- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 256 VDWsTGIAS-------GMNYLHLHKII-HRDLKSPNVLVTHTDAVKISDFG--TSKELSDKSTKMS-FAGTVAWMAPEVI 324
Cdd:cd14042  100 LDW-MFRYSlihdivkGMHYLHDSEIKsHGNLKSSNCVVDSRFVLKITDFGlhSFRSGQEPPDDSHaYYAKLLWTAPELL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 325 RNEPV----SEKVDIWSFGVVLWELLTGEIPY----KDVDSSAIIWGVGSNSLHLPV-----PSTCPDGFKILMKQTWQS 391
Cdd:cd14042  179 RDPNPpppgTQKGDVYSFGIILQEIATRQGPFyeegPDLSPKEIIKKKVRNGEKPPFrpsldELECPDEVLSLMQRCWAE 258
                        250
                 ....*....|....*
gi 755554055 392 KPRNRPSFRQTLMHL 406
Cdd:cd14042  259 DPEERPDFSTLRNKL 273
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
168-405 4.36e-31

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 122.94  E-value: 4.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 168 SELQWLGSGAQGAVFLG--KFRAEEVAIKKV----REQNET------DIKHLRKLKHPNIIAFKGvctqapCYC------ 229
Cdd:cd06607    4 EDLREIGHGSFGAVYYArnKRTSEVVAIKKMsysgKQSTEKwqdiikEVKFLRQLRHPNTIEYKG------CYLrehtaw 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAhGQLYEVLRAGRKitPRLLVDWST---GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSkelSDK 306
Cdd:cd06607   78 LVMEYCL-GSASDIVEVHKK--PLQEVEIAAichGALQGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSA---SLV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGTVAWMAPEVI--RNE-PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 383
Cdd:cd06607  152 CPANSFVGTPYWMAPEVIlaMDEgQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLSSGEWSDDFRN 231
                        250       260
                 ....*....|....*....|..
gi 755554055 384 LMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06607  232 FVDSCLQKIPQDRPSAEDLLKH 253
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
166-353 4.48e-31

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 123.20  E-value: 4.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE---EVAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd14202    3 EFSRKDLIGHGAFAVVFKGRHKEKhdlEVAVKCINKKNlaksqtllGKEIKILKELKHENIVALYDFQEIANSVYLVMEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKI---TPRLLVDwstGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---------VKISDFGTSKE 302
Cdd:cd14202   83 CNGGDLADYLHTMRTLsedTIRLFLQ---QIAGAMKMLHSKGIIHRDLKPQNILLSYSGGrksnpnnirIKIADFGFARY 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755554055 303 LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd14202  160 LQNNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTIIYQCLTGKAPFQ 210
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
158-355 5.38e-31

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 123.18  E-value: 5.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVpFEEIselqwlGSGAQGAVFLGKFR--AEEVAIK--KVREQNETDIKH----LRKL-KHPNIIAFKGVCTQAPCY 228
Cdd:cd06608    6 GIFEL-VEVI------GEGTYGKVYKARHKktGQLAAIKimDIIEDEEEEIKLeiniLRKFsNHPNIATFYGAFIKKDPP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 C------IIMEYCAHGQLYEVLRAGRKITPRLLVDW----STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG 298
Cdd:cd06608   79 GgddqlwLVMEYCGGGSVTDLVKGLRKKGKRLKEEWiayiLRETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFG 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 299 TSKELsdKSTKM---SFAGTVAWMAPEVI-----RNEPVSEKVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd06608  159 VSAQL--DSTLGrrnTFIGTPYWMAPEVIacdqqPDASYDARCDVWSLGITAIELADGKPPLCDM 221
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
176-406 7.60e-31

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 122.95  E-value: 7.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLGKFR-----AEEVAIKKVREQNE--------TDIKHLRKLKHPNIIAFKGVCTQAPCY-CIIMEYCAHGQLY 241
Cdd:cd05043   17 GTFGRIFHGILRdekgkEEEVLVKTVKDHASeiqvtmllQESSLLYGLSHQNLLPILHVCIEDGEKpMVLYPYMNWGNLK 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLR--------AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE--------LSD 305
Cdd:cd05043   97 LFLQqcrlseanNPQALSTQQLVHMALQIACGMSYLHRRGVIHKDIAARNCVIDDELQVKITDNALSRDlfpmdyhcLGD 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKmsfagTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVgSNSLHLPVPSTCPDGFKIL 384
Cdd:cd05043  177 NENR-----PIKWMSLESLVNKEYSSASDVWSFGVLLWELMTlGQTPYVEIDPFEMAAYL-KDGYRLAQPINCPDELFAV 250
                        250       260
                 ....*....|....*....|..
gi 755554055 385 MKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05043  251 MACCWALDPEERPSFQQLVQCL 272
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
171-405 1.12e-30

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 122.15  E-value: 1.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QW-----LGSGAqgavFLGKFRAEEV------AIKKV-------REQNET------DIKHLRKLKHPNIIAFKGVCTQAP 226
Cdd:cd06630    1 HWlkgplLGTGA----FSSCYQARDVktgtlmAVKQVsfcrnssSEQEEVveaireEIRMMARLNHPNIVRMLGATQHKS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA-VKISDFGTSKELSD 305
Cdd:cd06630   77 HFNIFVEWMAGGSVASLLSKYGAFSENVIINYTLQILRGLAYLHDNQIIHRDLKGANLLVDSTGQrLRIADFGAAARLAS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KST-----KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS---AIIWGVGSNSLHLPVPSTC 377
Cdd:cd06630  157 KGTgagefQGQLLGTIAFMAPEVLRGEQYGRSCDVWSVGCVIIEMATAKPPWNAEKISnhlALIFKIASATTPPPIPEHL 236
                        250       260
                 ....*....|....*....|....*...
gi 755554055 378 PDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06630  237 SPGLRDVTLRCLELQPEDRPPARELLKH 264
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
167-400 1.16e-30

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 122.32  E-value: 1.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVFLGKF------RAEEVAIKKVR----EQNET----DIKHLRKLKHPNIIAFKGVCTQA--PCYCI 230
Cdd:cd05080    6 LKKIRDLGEGHFGKVSLYCYdptndgTGEMVAVKALKadcgPQHRSgwkqEIDILKTLYHENIVKYKGCCSEQggKSLQL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST-- 308
Cdd:cd05080   86 IMEYVPLGSLRDYLPKHSIGLAQLLL-FAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEyy 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGT--VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI-IWGVGSNSL-------------HLP 372
Cdd:cd05080  165 RVREDGDspVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLeMIGIAQGQMtvvrliellergeRLP 244
                        250       260
                 ....*....|....*....|....*...
gi 755554055 373 VPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05080  245 CPDKCPQEVYHLMKNCWETEASFRPTFE 272
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
173-396 1.42e-30

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 121.69  E-value: 1.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGK--FRAEEVAIK---------------KVREQN-ETDIkHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd13993    8 IGEGAYGVVYLAVdlRTGRKYAIKclyksgpnskdgndfQKLPQLrEIDL-HRRVSRHPNIITLHDVFETEVAIYIVLEY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGR--KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSkelSDKSTKMS 311
Cdd:cd13993   87 CPNGDLFEAITENRiyVGKTELIKNVFLQLIDAVKHCHSLGIYHRDIKPENILLSqDEGTVKLCDFGLA---TTEKISMD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FA-GTVAWMAPEVIRNEPVSEK------VDIWSFGVVLWELLTGEIPYKDVDSSAII---WGVGSNSLhLPVPSTCPDGF 381
Cdd:cd13993  164 FGvGSEFYMAPECFDEVGRSLKgypcaaGDIWSLGIILLNLTFGRNPWKIASESDPIfydYYLNSPNL-FDVILPMSDDF 242
                        250
                 ....*....|....*
gi 755554055 382 KILMKQTWQSKPRNR 396
Cdd:cd13993  243 YNLLRQIFTVNPNNR 257
PTKc_IGF-1R cd05062
Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs ...
160-403 1.76e-30

Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. IGF-1R is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the ligand (IGF-1 or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, which stimulates downstream kinase activities and biological function. IGF-1R signaling is important in the differentiation, growth, and survival of normal cells. In cancer cells, where it is frequently overexpressed, IGF-1R is implicated in proliferation, the suppression of apoptosis, invasion, and metastasis. IGF-1R is being developed as a therapeutic target in cancer treatment. The IGF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133193 [Multi-domain]  Cd Length: 277  Bit Score: 121.68  E-value: 1.76e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRA-------EEVAIKKVREQ----------NETDIkhLRKLKHPNIIAFKGVC 222
Cdd:cd05062    1 WEVAREKITMSRELGQGSFGMVYEGIAKGvvkdepeTRVAIKTVNEAasmrerieflNEASV--MKEFNCHHVVRLLGVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQAPCYCIIMEYCAHGQLYEVLRAGRKIT--------PRL--LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV 292
Cdd:cd05062   79 SQGQPTLVIMELMTRGDLKSYLRSLRPEMennpvqapPSLkkMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 293 KISDFGTSKELSDKSTKMSFAG---TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNS 368
Cdd:cd05062  159 KIGDFGMTRDIYETDYYRKGGKgllPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATlAEQPYQGMSNEQVLRFVMEGG 238
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 369 LhLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd05062  239 L-LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEII 272
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
161-406 2.03e-30

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 122.85  E-value: 2.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGK--FRAEEVAIKKV----REQNET------DIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd06635   21 EDPEKLFSDLREIGHGSFGAVYFARdvRTSEVVAIKKMsysgKQSNEKwqdiikEVKFLQRIKHPNSIEYKGCYLREHTA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAhGQLYEVLRAGRKITPRLLVDWST-GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSkelSDKS 307
Cdd:cd06635  101 WLVMEYCL-GSASDLLEVHKKPLQEIEIAAIThGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSA---SIAS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSE---KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKIL 384
Cdd:cd06635  177 PANSFVGTPYWMAPEVILAMDEGQydgKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNF 256
                        250       260
                 ....*....|....*....|..
gi 755554055 385 MKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd06635  257 VDSCLQKIPQDRPTSEELLKHM 278
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
166-412 2.08e-30

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 121.67  E-value: 2.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE------EVAIKKVREQNETDIKH--------LRKLKHPNIIAFKGVCTQAPCYcII 231
Cdd:cd05109    8 ELKKVKVLGSGAFGTVYKGIWIPDgenvkiPVAIKVLRENTSPKANKeildeayvMAGVGSPYVCRLLGICLTSTVQ-LV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:cd05109   87 TQLMPYGCLLDYVRENKdRIGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAG---TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIwGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd05109  167 HADGgkvPIKWMALESILHRRFTHQSDVWSYGVTVWELMTfGAKPYDGIPAREIP-DLLEKGERLPQPPICTIDVYMIMV 245
                        250       260
                 ....*....|....*....|....*.
gi 755554055 387 QTWQSKPRNRPSFRQTLMHLDIASAD 412
Cdd:cd05109  246 KCWMIDSECRPRFRELVDEFSRMARD 271
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
164-405 2.10e-30

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 121.87  E-value: 2.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRA--EEVAIKKVREQ--------NETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd07830    1 YKVIKQL---GDGTFGSVYLARNKEtgELVAIKKMKKKfysweecmNLREVKSLRKLNeHPNIVKLKEVFRENDELYFVF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCaHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:cd07830   78 EYM-EGNLYQLMkdRKGKPFSESVIRSIIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAREIRSRPPYT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELLTG--------EI------------PYKDVDSSAI----IWG-- 363
Cdd:cd07830  157 DYVSTRWYRAPEILlRSTSYSSPVDIWALGCIMAELYTLrplfpgssEIdqlykicsvlgtPTKQDWPEGYklasKLGfr 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 364 ---VGSNSLHLPVPSTCPDGFKiLMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd07830  237 fpqFAPTSLHQLIPNASPEAID-LIKDMLRWDPKKRPTASQALQH 280
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
173-405 3.00e-30

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 120.92  E-value: 3.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL--GKFRAEEVAIKKV----------REQN--ETDIKHLRKLKHPNIIAFKGVC--TQAPCYCIIMEYCA 236
Cdd:cd06652   10 LGQGAFGRVYLcyDADTGRELAVKQVqfdpespetsKEVNalECEIQLLKNLLHERIVQYYGCLrdPQERTLSIFMEYMP 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS----DKSTKMSF 312
Cdd:cd06652   90 GGSIKDQLKSYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASKRLQticlSGTGMKSV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWqSK 392
Cdd:cd06652  170 TGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPAHVSDHCRDFLKRIF-VE 248
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd06652  249 AKLRPSADELLRH 261
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
192-401 4.03e-30

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 121.25  E-value: 4.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 192 AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR------AGRKITPRLLVDWS------ 259
Cdd:cd05095   58 ANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITDDPLCMITEYMENGDLNQFLSrqqpegQLALPSNALTVSYSdlrfma 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKMSFAGT--VAWMAPEVIRNEPVSEKVDIW 336
Cdd:cd05095  138 AQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLySGDYYRIQGRAVlpIRWMSWESILLGKFTTASDVW 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755554055 337 SFGVVLWELLT--GEIPYKDVDSSAIIWGVGS------NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05095  218 AFGVTLWETLTfcREQPYSQLSDEQVIENTGEffrdqgRQTYLPQPALCPDSVYKLMLSCWRRDTKDRPSFQE 290
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
173-399 4.96e-30

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 120.30  E-value: 4.96e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKV-------REQNET---DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14027    1 LDSGGFGKVSLCFHRTQGLVVLKTvytgpncIEHNEAlleEGKMMNRLRHSRVVKLLGVILEEGKYSLVMEYMEKGNLMH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGR---KITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT-------------SKELSD- 305
Cdd:cd14027   81 VLKKVSvplSVKGRIILE----IIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLasfkmwskltkeeHNEQREv 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGTVAWMAPEVIR--NEPVSEKVDIWSFGVVLWELLTGEIPYKD-VDSSAIIWGV--GSNSLHLPVPSTCPDG 380
Cdd:cd14027  157 DGTAKKNAGTLYYMAPEHLNdvNAKPTEKSDVYSFAIVLWAIFANKEPYENaINEDQIIMCIksGNRPDVDDITEYCPRE 236
                        250
                 ....*....|....*....
gi 755554055 381 FKILMKQTWQSKPRNRPSF 399
Cdd:cd14027  237 IIDLMKLCWEANPEARPTF 255
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
173-405 5.24e-30

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 119.78  E-value: 5.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA---EEVAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14120    1 IGHGAFAVVFKGRHRKkpdLPVAIKCITKKNlsksqnllGKEIKILKELSHENVVALLDCQETSSSVYLVMEYCNGGDLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKI---TPRLLVdwsTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---------VKISDFGTSKELSDKSTK 309
Cdd:cd14120   81 DYLQAKGTLsedTIRVFL---QQIAAAMKALHSKGIVHRDLKPQNILLSHNSGrkpspndirLKIADFGFARFLQDGMMA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLPVPSTCPDGFKILMKQT 388
Cdd:cd14120  158 ATLCGSPMYMAPEVIMSLQYDAKADLWSIGTIVYQCLTGKAPFQAQTPQELKAFYEKNaNLRPNIPSGTSPALKDLLLGL 237
                        250
                 ....*....|....*..
gi 755554055 389 WQSKPRNRPSFRQTLMH 405
Cdd:cd14120  238 LKRNPKDRIDFEDFFSH 254
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
173-405 5.82e-30

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 119.29  E-value: 5.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK--KVREQNETDIKH----LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 244
Cdd:cd14006    1 LGRGRFGVVKRCIEKAtgREFAAKfiPKRDKKKEAVLReisiLNQLQHPRIIQLHEAYESPTELVLILELCSGGELLDRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKSTKMSFAGTVAWMAPE 322
Cdd:cd14006   81 AERGSLSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLADRPSpqIKIIDFGLARKLNPGEELKEIFGTPEFVAPE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 323 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL--PVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd14006  161 IVNGEPVSLATDMWSIGVLTYVLLSGLSPFLGEDDQETLANISACRVDFseEYFSSVSQEAKDFIRKLLVKEPRKRPTAQ 240

                 ....*
gi 755554055 401 QTLMH 405
Cdd:cd14006  241 EALQH 245
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
154-427 1.26e-29

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 119.75  E-value: 1.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 154 LQQQDTWEVPFEeiselqwLGSGAQGAVFLGKFRAEEV--AIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQ 224
Cdd:cd06644    8 LDPNEVWEIIGE-------LGDGAFGKVYKAKNKETGAlaAAKVIETKSEeeledymVEIEILATCNHPYIVKLLGAFYW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 225 APCYCIIMEYCAHGQLYEV-LRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS-KE 302
Cdd:cd06644   81 DGKLWIMIEFCPGGAVDAImLELDRGLTEPQIQVICRQMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFGVSaKN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 303 LSDKSTKMSFAGTVAWMAPEVI-----RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG-SNSLHLPVPST 376
Cdd:cd06644  161 VKTLQRRDSFIGTPYWMAPEVVmcetmKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAkSEPPTLSQPSK 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755554055 377 CPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAE 427
Cdd:cd06644  241 WSMEFRDFLKTALDKHPETRPSAAQLLEHPFVSSVTSNRPLRELVAEAKAE 291
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
163-405 1.44e-29

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 118.49  E-value: 1.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06647    5 PKKKYTRFEKIGQGASGTVYTAIDVAtgQEVAIKQMNLQQQpkkeliiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVlragrkITPRLLVDWSTG-----IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS 307
Cdd:cd06647   85 YLAGGSLTDV------VTETCMDEGQIAavcreCLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpEQS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL-HLPVPSTCPDGFKILMK 386
Cdd:cd06647  159 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTpELQNPEKLSAIFRDFLN 238
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd06647  239 RCLEMDVEKRGSAKELLQH 257
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
163-405 1.81e-29

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 119.74  E-value: 1.81e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGK-FRAEEV-AIKKV----REQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd06634   13 PEKLFSDLREIGHGSFGAVYFARdVRNNEVvAIKKMsysgKQSNEKwqdiikEVKFLQKLRHPNTIEYRGCYLREHTAWL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAhGQLYEVLRAGRKITPRLLVDWST-GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKStk 309
Cdd:cd06634   93 VMEYCL-GSASDLLEVHKKPLQEVEIAAIThGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAPAN-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 mSFAGTVAWMAPEVIRNEPVSE---KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd06634  170 -SFVGTPYWMAPEVILAMDEGQydgKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVD 248
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd06634  249 SCLQKIPQDRPTSDVLLKH 267
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
160-406 1.89e-29

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 119.33  E-value: 1.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WE-VPFEEIselqwLGSGAQGAVFLGKFRAE----EVAIKKVRE-QNETD-------IKHLRKL-KHPNIIAFKGVCTQA 225
Cdd:cd05089    1 WEdIKFEDV-----IGEGNFGQVIKAMIKKDglkmNAAIKMLKEfASENDhrdfageLEVLCKLgHHPNIINLLGACENR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT 289
Cdd:cd05089   76 GYLYIAIEYAPYGNLLDFLRKSRvletdpafakehgtasTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGEN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 290 DAVKISDFGTSK--ELSDKSTKMSFAgtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVdSSAIIWGVGS 366
Cdd:cd05089  156 LVSKIADFGLSRgeEVYVKKTMGRLP--VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSlGGTPYCGM-TCAELYEKLP 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755554055 367 NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05089  233 QGYRMEKPRNCDDEVYELMRQCWRDRPYERPPFSQISVQL 272
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
202-401 1.91e-29

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 118.51  E-value: 1.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 202 TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKS 281
Cdd:cd14222   39 TEVKVMRSLDHPNVLKFIGVLYKDKRLNLLTEFIEGGTLKDFLRADDPFPWQQKVSFAKGIASGMAYLHSMSIIHRDLNS 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 282 PNVLVTHTDAVKISDFGTSKEL---------------------SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGV 340
Cdd:cd14222  119 HNCLIKLDKTVVVADFGLSRLIveekkkpppdkpttkkrtlrkNDRKKRYTVVGNPYWMAPEMLNGKSYDEKVDIFSFGI 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 341 VLWELLtGEIpYKDVDSSAIIWGVGSNS---LHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd14222  199 VLCEII-GQV-YADPDCLPRTLDFGLNVrlfWEKFVPKDCPPAFFPLAAICCRLEPDSRPAFSK 260
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
163-405 3.02e-29

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 118.24  E-value: 3.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLG--KFRAEEVAIKKVR--------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06642    2 PEELFTKLERIGKGSFGEVYKGidNRTKEVVAIKIIDleeaedeiEDIQQEITVLSQCDSPYITRYYGSYLKGTKLWIIM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS- 311
Cdd:cd06642   82 EYLGGGSALDLLKPG-PLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNt 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlhlpvPSTC----PDGFKILMKQ 387
Cdd:cd06642  161 FVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNS-----PPTLegqhSKPFKEFVEA 235
                        250
                 ....*....|....*...
gi 755554055 388 TWQSKPRNRPSFRQTLMH 405
Cdd:cd06642  236 CLNKDPRFRPTAKELLKH 253
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
161-399 4.16e-29

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 118.15  E-value: 4.16e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAV----------FLGKFRAEE------VAIKKVR-EQNET-------DIKHLRKLKHPNII 216
Cdd:cd05097    1 EFPRQQLRLKEKLGEGQFGEVhlceaeglaeFLGEGAPEFdgqpvlVAVKMLRaDVTKTarndflkEIKIMSRLKNPNII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 217 AFKGVCTQAPCYCIIMEYCAHGQLYEVLrAGRKITPRL-------------LVDWSTGIASGMNYLHLHKIIHRDLKSPN 283
Cdd:cd05097   81 RLLGVCVSDDPLCMITEYMENGDLNQFL-SQREIESTFthannipsvsianLLYMAVQIASGMKYLASLNFVHRDLATRN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 284 VLVTHTDAVKISDFGTSKEL-SDKSTKMSFAGT--VAWMAPEVIRNEPVSEKVDIWSFGVVLWEL--LTGEIPYKDVDSS 358
Cdd:cd05097  160 CLVGNHYTIKIADFGMSRNLySGDYYRIQGRAVlpIRWMAWESILLGKFTTASDVWAFGVTLWEMftLCKEQPYSLLSDE 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 359 AIIWGVGS------NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 399
Cdd:cd05097  240 QVIENTGEffrnqgRQIYLSQTPLCPSPVFKLMMRCWSRDIKDRPTF 286
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
173-351 4.41e-29

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 117.60  E-value: 4.41e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKF-RAEEVAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd14664    1 IGRGGAGTVYKGVMpNGTLVAVKRLKGEGtqggdhgfQAEIQTLGMIRHRNIVRLRGYCSNPTTNLLVYEYMPNGSLGEL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGRKITPRLlvDWST------GIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM--SF 312
Cdd:cd14664   81 LHSRPESQPPL--DWETrqrialGSARGLAYLHHDcspLIIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDSHVmsSV 158
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP 351
Cdd:cd14664  159 AGSYGYIAPEYAYTGKVSEKSDVYSYGVVLLELITGKRP 197
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
173-352 4.71e-29

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 117.00  E-value: 4.71e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVF--LGKFRAEE-VAIKKV---------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14121    3 LGSGTYATVYkaYRKSGAREvVAVKCVsksslnkasTENLLTEIELLKKLKHPHIVELKDFQWDEEHIYLIMEYCSGGDL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT--HTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14121   83 SRFIRSRRTLPESTVRRFLQQLASALQFLREHNISHMDLKPQNLLLSsrYNPVLKLADFGFAQHLKPNDEAHSLRGSPLY 162
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14121  163 MAPEMILKKKYDARVDLWSVGVILYECLFGRAPF 196
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
173-352 4.74e-29

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 117.16  E-value: 4.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKK--VREQ-------NETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd06648   15 IGEGSTGIVCIAtdKSTGRQVAVKKmdLRKQqrrellfNEVVI--MRDYQHPNIVEMYSSYLVGDELWVVMEFLEGGALT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRkITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMA 320
Cdd:cd06648   93 DIVTHTR-MNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGFCAQVSKEVPRRkSLVGTPYWMA 171
                        170       180       190
                 ....*....|....*....|....*....|..
gi 755554055 321 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd06648  172 PEVISRLPYGTEVDIWSLGIMVIEMVDGEPPY 203
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
173-405 5.10e-29

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 116.76  E-value: 5.10e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKV---------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd08220    8 VGRGAYGTVYLCRRKDdnKLVIIKQIpveqmtkeeRQAALNEVKVLSMLHHPNIIEYYESFLEDKALMIVMEYAPGGTLF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd08220   88 EYIqqRKGSLLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNkKRTVVKIGDFGISKILSSKSKAYTVVGTPCY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDGFKILMKQTWQSKPRNRPS 398
Cdd:cd08220  168 ISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMRGT-FAPISDRYSEELRHLILSMLHLDPNKRPT 246

                 ....*..
gi 755554055 399 FRQTLMH 405
Cdd:cd08220  247 LSEIMAQ 253
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
163-405 5.61e-29

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 117.48  E-value: 5.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLG-KFRAEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06641    2 PEELFTKLEKIGKGSFGEVFKGiDNRTQKVVAIKIIDLEEAEdeiediqqeITVLSQCDSPYVTKYYGSYLKDTKLWIIM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS- 311
Cdd:cd06641   82 EYLGGGSALDLLEPG-PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN* 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLpVPSTCPDGFKILMKQTWQS 391
Cdd:cd06641  161 FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPT-LEGNYSKPLKEFVEACLNK 239
                        250
                 ....*....|....
gi 755554055 392 KPRNRPSFRQTLMH 405
Cdd:cd06641  240 EPSFRPTAKELLKH 253
PTKc_DDR1 cd05096
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze ...
192-401 5.72e-29

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133227 [Multi-domain]  Cd Length: 304  Bit Score: 118.11  E-value: 5.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 192 AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-------------------GRKITP 252
Cdd:cd05096   58 ANKNARNDFLKEVKILSRLKDPNIIRLLGVCVDEDPLCMITEYMENGDLNQFLSShhlddkeengndavppahcLPAISY 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 253 RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsdkstkmsFAGT-----------VAWMAP 321
Cdd:cd05096  138 SSLLHVALQIASGMKYLSSLNFVHRDLATRNCLVGENLTIKIADFGMSRNL--------YAGDyyriqgravlpIRWMAW 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 322 EVIRNEPVSEKVDIWSFGVVLWELLT--GEIPYKDVDSSAIIWGVGS------NSLHLPVPSTCPDGFKILMKQTWQSKP 393
Cdd:cd05096  210 ECILMGKFTTASDVWAFGVTLWEILMlcKEQPYGELTDEQVIENAGEffrdqgRQVYLFRPPPCPQGLYELMLQCWSRDC 289

                 ....*...
gi 755554055 394 RNRPSFRQ 401
Cdd:cd05096  290 RERPSFSD 297
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
173-405 6.22e-29

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 117.05  E-value: 6.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL--GKFRAEEVAIKKV----------REQN--ETDIKHLRKLKHPNIIAFKGvCTQAP---CYCIIMEYC 235
Cdd:cd06653   10 LGRGAFGEVYLcyDADTGRELAVKQVpfdpdsqetsKEVNalECEIQLLKNLRHDRIVQYYG-CLRDPeekKLSIFVEYM 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---KSTKM-S 311
Cdd:cd06653   89 PGGSVKDQLKAYGALTENVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTicmSGTGIkS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS 391
Cdd:cd06653  169 VTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWAEYEAMAAIFKIATQPTKPQLPDGVSDACRDFLRQIFVE 248
                        250
                 ....*....|....
gi 755554055 392 KPRnRPSFRQTLMH 405
Cdd:cd06653  249 EKR-RPTAEFLLRH 261
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
203-407 1.08e-28

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 116.04  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 203 DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSP 282
Cdd:cd14155   38 EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINGGNLEQLLDSNEPLSWTVRVKLALDIARGLSYLHSKGIFHRDLTSK 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 283 NVLVTHTD----AVkISDFGTSKEL---SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtGEIPYK-D 354
Cdd:cd14155  118 NCLIKRDEngytAV-VGDFGLAEKIpdySDGKEKLAVVGSPYWMAPEVLRGEPYNEKADVFSYGIILCEII-ARIQADpD 195
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755554055 355 VDSSAIIWGVGSNSLHLPVPStCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14155  196 YLPRTEDFGLDYDAFQHMVGD-CPPDFLQLAFNCCNMDPKSRPSFHDIVKTLE 247
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
160-406 1.11e-28

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 117.21  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVF------LGKFRA-EEVAIKKVRE---QNE-----TDIKHLRKL-KHPNIIAFKGVCT 223
Cdd:cd05054    2 WEFPRDRLKLGKPLGRGAFGKVIqasafgIDKSATcRTVAVKMLKEgatASEhkalmTELKILIHIgHHLNVVNLLGACT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 Q--APCYcIIMEYCAHGQLYEVLRAGRK--------------------------ITPRLLVDWSTGIASGMNYLHLHKII 275
Cdd:cd05054   82 KpgGPLM-VIVEFCKFGNLSNYLRSKREefvpyrdkgardveeeedddelykepLTLEDLICYSFQVARGMEFLASRKCI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 276 HRDLKSPNVLVTHTDAVKISDFGTSKEL---SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIP 351
Cdd:cd05054  161 HRDLAARNILLSENNVVKICDFGLARDIykdPDYVRKGDARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSlGASP 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 352 YKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05054  241 YPGVQMDEEFCRRLKEGTRMRAPEYTTPEIYQIMLDCWHGEPKERPTFSELVEKL 295
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
163-405 1.11e-28

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 116.69  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLG-KFRAEEV-AIKKVR--------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06640    2 PEELFTKLERIGKGSFGEVFKGiDNRTQQVvAIKIIDleeaedeiEDIQQEITVLSQCDSPYVTKYYGSYLKGTKLWIIM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-S 311
Cdd:cd06640   82 EYLGGGSALDLLRAG-PFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRnT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNslhlPVPSTCPD---GFKILMKQT 388
Cdd:cd06640  161 FVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN----NPPTLVGDfskPFKEFIDAC 236
                        250
                 ....*....|....*..
gi 755554055 389 WQSKPRNRPSFRQTLMH 405
Cdd:cd06640  237 LNKDPSFRPTAKELLKH 253
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
166-401 1.21e-28

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 117.09  E-value: 1.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE------EVAIKKVREQN--ETDIKHLRK------LKHPNIIAFKGVCTqAPCYCII 231
Cdd:cd05110    8 ELKRVKVLGSGAFGTVYKGIWVPEgetvkiPVAIKILNETTgpKANVEFMDEalimasMDHPHLVRLLGVCL-SPTIQLV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM 310
Cdd:cd05110   87 TQLMPHGCLLDYVHEHKdNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAG---TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIwGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd05110  167 NADGgkmPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTfGGKPYDGIPTREIP-DLLEKGERLPQPPICTIDVYMVMV 245
                        250
                 ....*....|....*
gi 755554055 387 QTWQSKPRNRPSFRQ 401
Cdd:cd05110  246 KCWMIDADSRPKFKE 260
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
169-405 1.82e-28

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 115.72  E-value: 1.82e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFRA--EEVAIKKV---------REQ--NETDIkhLRKLKHPNIIAFKG--VCTQAPCYCIIME 233
Cdd:cd08217    4 VLETIGKGSFGTVRKVRRKSdgKILVWKEIdygkmsekeKQQlvSEVNI--LRELKHPNIVRYYDriVDRANTTLYIVME 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVD--WS--TGIASGMNYLHL-----HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS 304
Cdd:cd08217   82 YCEGGDLAQLIKKCKKENQYIPEEfiWKifTQLLLALYECHNrsvggGKILHRDLKPANIFLDSDNNVKLGDFGLARVLS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 305 DKS--TKmSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYkdvdssaiiwgVGSNSLHL----------P 372
Cdd:cd08217  162 HDSsfAK-TYVGTPYYMSPELLNEQSYDEKSDIWSLGCLIYELCALHPPF-----------QAANQLELakkikegkfpR 229
                        250       260       270
                 ....*....|....*....|....*....|...
gi 755554055 373 VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd08217  230 IPSRYSSELNEVIKSMLNVDPDKRPSVEELLQL 262
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
166-353 2.26e-28

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 115.49  E-value: 2.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE---EVAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd14201    7 EYSRKDLVGHGAFAVVFKGRHRKKtdwEVAIKSINKKNLSksqillgkEIKILKELQHENIVALYDVQEMPNSVFLVMEY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---------VKISDFGTSKELSD 305
Cdd:cd14201   87 CNGGDLADYLQAKGTLSEDTIRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSYASRkkssvsgirIKIADFGFARYLQS 166
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 306 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd14201  167 NMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQ 214
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
166-401 2.30e-28

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 115.82  E-value: 2.30e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE------EVAIKKVRE-------QNETD-IKHLRKLKHPNIIAFKGVCTqAPCYCII 231
Cdd:cd05111    8 ELRKLKVLGSGVFGTVHKGIWIPEgdsikiPVAIKVIQDrsgrqsfQAVTDhMLAIGSLDHAYIVRLLGICP-GASLQLV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL--SDKST 308
Cdd:cd05111   87 TQLLPLGSLLDHVRQHRgSLGPQLLLNWCVQIAKGMYYLEEHRMVHRNLAARNVLLKSPSQVQVADFGVADLLypDDKKY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGT-VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIwGVGSNSLHLPVPSTCPDGFKILMK 386
Cdd:cd05111  167 FYSEAKTpIKWMALESIHFGKYTHQSDVWSYGVTVWEMMTfGAEPYAGMRLAEVP-DLLEKGERLAQPQICTIDVYMVMV 245
                        250
                 ....*....|....*
gi 755554055 387 QTWQSKPRNRPSFRQ 401
Cdd:cd05111  246 KCWMIDENIRPTFKE 260
PTKc_Tyro3 cd05074
Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the ...
173-407 3.39e-28

Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyro3 (or Sky) is predominantly expressed in the central nervous system and the brain, and functions as a neurotrophic factor. It is also expressed in osteoclasts and has a role in bone resorption. Tyro3 is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Tyro3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270659 [Multi-domain]  Cd Length: 284  Bit Score: 115.40  E-value: 3.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-----VAIKKVREQ--NETDIKH-------LRKLKHPNIIAFKGVCTQA------PCYCIIM 232
Cdd:cd05074   17 LGKGEFGSVREAQLKSEDgsfqkVAVKMLKADifSSSDIEEflreaacMKEFDHPNVIKLIGVSLRSrakgrlPIPMVIL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGR------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SD 305
Cdd:cd05074   97 PFMKHGDLHTFLLMSRigeepfTLPLQTLVRFMIDIASGMEYLSSKNFIHRDLAARNCMLNENMTVCVADFGLSKKIySG 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGT--VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAII-WGVGSNslHLPVPSTCPDGF 381
Cdd:cd05074  177 DYYRQGCASKlpVKWLALESLADNVYTTHSDVWAFGVTMWEIMTrGQTPYAGVENSEIYnYLIKGN--RLKQPPDCLEDV 254
                        250       260
                 ....*....|....*....|....*.
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05074  255 YELMCQCWSPEPKCRPSFQHLRDQLE 280
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
170-372 4.61e-28

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 114.28  E-value: 4.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRA-EEVAIKKVRE---QNETDIKHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd14161    8 LETLGKGTYGRVKKARDSSgRLVAIKSIRKdriKDEQDLLHIRReieimssLNHPHIISVYEVFENSSKIVIVMEYASRG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14161   88 DLYDYISERQRLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGLSNLYNQDKFLQTYCGSPLY 167
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 319 MAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372
Cdd:cd14161  168 ASPEIVNGRPyIGPEVDSWSLGVLLYILVHGTMPFDGHDYKILVKQISSGAYREP 222
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
173-398 6.08e-28

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 114.25  E-value: 6.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIK---------KVREQNETDIKHLRK-------------------LKHPNIIAFKGVCTQ 224
Cdd:cd14000    2 LGDGGFGSVYRASYKGEPVAVKifnkhtssnFANVPADTMLRHLRAtdamknfrllrqeltvlshLHHPSIVYLLGIGIH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 225 ApcYCIIMEYCAHGQLYEVL----RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA-----VKIS 295
Cdd:cd14000   82 P--LMLVLELAPLGSLDHLLqqdsRSFASLGRTLQQRIALQVADGLRYLHSAMIIYRDLKSHNVLVWTLYPnsaiiIKIA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 296 DFGTSKElSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI---IWGVGSNSLHL 371
Cdd:cd14000  160 DYGISRQ-CCRMGAKGSEGTPGFRAPEIARgNVIYNEKVDVFSFGMLLYEILSGGAPMVGHLKFPNefdIHGGLRPPLKQ 238
                        250       260
                 ....*....|....*....|....*....
gi 755554055 372 P--VPSTCpdgFKILMKQTWQSKPRNRPS 398
Cdd:cd14000  239 YecAPWPE---VEVLMKKCWKENPQQRPT 264
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
173-356 6.28e-28

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 113.71  E-value: 6.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL--GKFRAEEVAIK------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE-V 243
Cdd:cd14662    8 IGSGNFGVARLmrNKETKELVAVKyierglKIDENVQREIINHRSLRHPNIIRFKEVVLTPTHLAIVMEYAAGGELFErI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGR--KITPRLLVDwstGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKSTKMSFAGTVAWM 319
Cdd:cd14662   88 CNAGRfsEDEARYFFQ---QLISGVSYCHSMQICHRDLKLENTLLDGSPAprLKICDFGYSKSSVLHSQPKSTVGTPAYI 164
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 320 APEVI-RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd14662  165 APEVLsRKEYDGKVADVWSCGVTLYVMLVGAYPFEDPD 202
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
193-358 6.65e-28

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 113.94  E-value: 6.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 193 IKKVReqNETDIkhLRKLKHPNIIAFKGVC-TQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHL 271
Cdd:cd13994   41 VKRLT--SEYII--SSKLHHPNIVKVLDLCqDLHGKWCLVMEYCPGGDLFTLIEKADSLSLEEKDCFFKQILRGVAYLHS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 272 HKIIHRDLKSPNVLVTHTDAVKISDFGTS---KELSDKSTKMSFA--GTVAWMAPEVIRNEPVSEK-VDIWSFGVVLWEL 345
Cdd:cd13994  117 HGIAHRDLKPENILLDEDGVLKLTDFGTAevfGMPAEKESPMSAGlcGSEPYMAPEVFTSGSYDGRaVDVWSCGIVLFAL 196
                        170
                 ....*....|...
gi 755554055 346 LTGEIPYKDVDSS 358
Cdd:cd13994  197 FTGRFPWRSAKKS 209
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
173-401 6.85e-28

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 113.59  E-value: 6.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIK---KVREQNET------DIKHLRKLKHPNIIA-FKGVCTQAPCYcIIMEYCAHGQL 240
Cdd:cd14075   10 LGSGNFSQVKLGihQLTKEKVAIKildKTKLDQKTqrllsrEISSMEKLHHPNIIRlYEVVETLSKLH-LVMEYASGGEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMA 320
Cdd:cd14075   89 YTKISTEGKLSESEAKPLFAQIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHAKRGETLNTFCGSPPYAA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 321 PEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYK--DVDS--SAIIWGvgsnslHLPVPSTCPDGFKILMKQTWQSKPRN 395
Cdd:cd14075  169 PELFKDEHyIGIYVDIWALGVLLYFMVTGVMPFRaeTVAKlkKCILEG------TYTIPSYVSEPCQELIRGILQPVPSD 242

                 ....*.
gi 755554055 396 RPSFRQ 401
Cdd:cd14075  243 RYSIDE 248
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
154-405 1.03e-27

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 113.97  E-value: 1.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 154 LQQQDTWEVPFEeiselqwLGSGAQGAVF------LGKFRAEEVAIKKVREQNE---TDIKHLRKLKHPNIIAFKGVCTQ 224
Cdd:cd06643    1 LNPEDFWEIVGE-------LGDGAFGKVYkaqnkeTGILAAAKVIDTKSEEELEdymVEIDILASCDHPNIVKLLDAFYY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 225 APCYCIIMEYCAHGQLYEV-LRAGRKIT-PRLLVDWSTGIASgMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS-K 301
Cdd:cd06643   74 ENNLWILIEFCAGGAVDAVmLELERPLTePQIRVVCKQTLEA-LVYLHENKIIHRDLKAGNILFTLDGDIKLADFGVSaK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSDKSTKMSFAGTVAWMAPEVI-----RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG-SNSLHLPVPS 375
Cdd:cd06643  153 NTRTLQRRDSFIGTPYWMAPEVVmcetsKDRPYDYKADVWSLGVTLIEMAQIEPPHHELNPMRVLLKIAkSEPPTLAQPS 232
                        250       260       270
                 ....*....|....*....|....*....|
gi 755554055 376 TCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06643  233 RWSPEFKDFLRKCLEKNVDARWTTSQLLQH 262
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
164-406 1.23e-27

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 113.35  E-value: 1.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEE--VAIKKVREQN---ETDIKHLRKLKHPNIIAFKGvCTQAPCYC--------- 229
Cdd:cd14047    8 FKEIELI---GSGGFGQVFKAKHRIDGktYAIKRVKLNNekaEREVKALAKLDHPNIVRYNG-CWDGFDYDpetsssnss 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 --------IIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT 299
Cdd:cd14047   84 rsktkclfIQMEFCEKGTLESWIekRNGEKLDKVLALEIFEQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFGL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 300 SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTgeiPYKDVDSSAIIWGVGSNslhlpvpSTCPD 379
Cdd:cd14047  164 VTSLKNDGKRTKSKGTLSYMSPEQISSQDYGKEVDIYALGLILFELLH---VCDSAFEKSKFWTDLRN-------GILPD 233
                        250       260       270
                 ....*....|....*....|....*....|....
gi 755554055 380 GF-------KILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd14047  234 IFdkrykieKTIIKKMLSKKPEDRPNASEILRTL 267
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
173-349 1.60e-27

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 113.57  E-value: 1.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHgQLY 241
Cdd:cd07833    9 VGEGAYGVVLKCRNKAtgEIVAIKKFKESEDDEdvkktalreVKVLRQLRHENIVNLKEAFRRKGRLYLVFEYVER-TLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPRLLVDWST-GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK--MSFAGTVAW 318
Cdd:cd07833   88 ELLEASPGGLPPDAVRSYIwQLLQAIAYCHSHNIIHRDIKPENILVSESGVLKLCDFGFARALTARPASplTDYVATRWY 167
                        170       180       190
                 ....*....|....*....|....*....|..
gi 755554055 319 MAPEVIRNEPVSEK-VDIWSFGVVLWELLTGE 349
Cdd:cd07833  168 RAPELLVGDTNYGKpVDVWAIGCIMAELLDGE 199
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
173-356 1.67e-27

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 112.39  E-value: 1.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE-V 243
Cdd:cd14665    8 IGSGNFGVARLMRDKQtkELVAVKyiergeKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYAAGGELFErI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGR--KITPRLLVDwstGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKSTKMSFAGTVAWM 319
Cdd:cd14665   88 CNAGRfsEDEARFFFQ---QLISGVSYCHSMQICHRDLKLENTLLDGSPAprLKICDFGYSKSSVLHSQPKSTVGTPAYI 164
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 320 APEVIRNEPVSEKV-DIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd14665  165 APEVLLKKEYDGKIaDVWSCGVTLYVMLVGAYPFEDPE 202
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
173-354 1.67e-27

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 112.47  E-value: 1.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK-------KVREQN-ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14083   11 LGTGAFSEVVLAEDKAtgKLVAIKcidkkalKGKEDSlENEIAVLRKIKHPNIVQLLDIYESKSHLYLVMELVTGGELFD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKelSDKSTKMSFA-GTVAW 318
Cdd:cd14083   91 RIVEKGSYTEKDASHLIRQVLEAVDYLHSLGIVHRDLKPENLLYYSPDedsKIMISDFGLSK--MEDSGVMSTAcGTPGY 168
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14083  169 VAPEVLAQKPYGKAVDCWSIGVISYILLCGYPPFYD 204
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
182-405 1.73e-27

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 112.65  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 182 FLGKFRAEEVAIkkvreqnetdikhLRKLKHPNII-AFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPrLLVDWST 260
Cdd:cd14164   42 FVQKFLPRELSI-------------LRRVNHPNIVqMFECIEVANGRLYIVMEAAATDLLQKIQEVHHIPKD-LARDMFA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 261 GIASGMNYLHLHKIIHRDLKSPNVLVTHTD-AVKISDFGTSKELSDKST-KMSFAGTVAWMAPEVIRNEPV-SEKVDIWS 337
Cdd:cd14164  108 QMVGAVNYLHDMNIVHRDLKCENILLSADDrKIKIADFGFARFVEDYPElSTTFCGSRAYTPPEVILGTPYdPKKYDVWS 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 338 FGVVLWELLTGEIPYKDVDSSAIiwgvgsnsLHLPVPSTCPDGF------KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14164  188 LGVVLYVMVTGTMPFDETNVRRL--------RLQQRGVLYPSGValeepcRALIRTLLQFNPSTRPSIQQVAGN 253
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
173-409 1.76e-27

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 112.81  E-value: 1.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIK----KVREQNETDIKH----LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14167   11 LGTGAFSEVVLAEEKRTQklVAIKciakKALEGKETSIENeiavLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKeLSDKSTKMSFA-GTVAW 318
Cdd:cd14167   91 RIVEKGFYTERDASKLIFQILDAVKYLHDMGIVHRDLKPENLLYYSLDedsKIMISDFGLSK-IEGSGSVMSTAcGTPGY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP--STCPDGFKILMKQTWQSKPRNR 396
Cdd:cd14167  170 VAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPywDDISDSAKDFIQHLMEKDPEKR 249
                        250
                 ....*....|...
gi 755554055 397 PSFRQTLMHLDIA 409
Cdd:cd14167  250 FTCEQALQHPWIA 262
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
173-405 2.28e-27

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 111.96  E-value: 2.28e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIK----------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14081    9 LGKGQTGLVKLAKHCvtGQKVAIKivnkeklskeSVLMKVEREIAIMKLIEHPNVLKLYDVYENKKYLYLVLEYVSGGEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG-TSKELSDKSTKMSfAGTVAWM 319
Cdd:cd14081   89 FDYLVKKGRLTEKEARKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGmASLQPEGSLLETS-CGSPHYA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 320 APEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSTCPDgfkiLMKQTWQSKPRNR 396
Cdd:cd14081  168 CPEVIKGEKYdGRKADIWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPhfISPDAQD----LLRRMLEVNPEKR 243

                 ....*....
gi 755554055 397 PSFRQTLMH 405
Cdd:cd14081  244 ITIEEIKKH 252
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
173-405 2.45e-27

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 112.11  E-value: 2.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKF--RAEEVAIK--------KVR--EQNETDIKHLRKLKHPNIIAFKGV-CTQAPCYcIIMEYCAHGQ 239
Cdd:cd14663    8 LGEGTFAKVKFARNtkTGESVAIKiidkeqvaREGmvEQIKREIAIMKLLRHPNIVELHEVmATKTKIF-FVMELVTGGE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS---KELSDKSTKMSFAGTV 316
Cdd:cd14663   87 LFSKIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLSalsEQFRQDGLLHTTCGTP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNslHLPVPSTCPDGFKILMKQTWQSKPRN 395
Cdd:cd14663  167 NYVAPEVLARRGyDGAKADIWSCGVILFVLLAGYLPFDDENLMALYRKIMKG--EFEYPRWFSPGAKSLIKRILDPNPST 244
                        250
                 ....*....|
gi 755554055 396 RPSFRQTLMH 405
Cdd:cd14663  245 RITVEQIMAS 254
PTKc_Tie2 cd05088
Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the ...
170-407 2.54e-27

Catalytic domain of the Protein Tyrosine Kinase, Tie2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie2 is a receptor PTK (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie2 is expressed mainly in endothelial cells and hematopoietic stem cells. It is also found in a subset of tumor-associated monocytes and eosinophils. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. Tie2 signaling plays key regulatory roles in vascular integrity and quiescence, and in inflammation. The Tie2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133219 [Multi-domain]  Cd Length: 303  Bit Score: 113.17  E-value: 2.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQW--------LGSGAQGAVFLGKFRAE----EVAIKKVREQNETD--------IKHLRKL-KHPNIIAFKGVCTQAPCY 228
Cdd:cd05088    4 LEWndikfqdvIGEGNFGQVLKARIKKDglrmDAAIKRMKEYASKDdhrdfageLEVLCKLgHHPNIINLLGACEHRGYL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGR----------------KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV 292
Cdd:cd05088   84 YLAIEYAPHGNLLDFLRKSRvletdpafaianstasTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 293 KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVdSSAIIWGVGSNSLHL 371
Cdd:cd05088  164 KIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSlGGTPYCGM-TCAELYEKLPQGYRL 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 372 PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05088  243 EKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN 278
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
164-380 3.36e-27

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 112.91  E-value: 3.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEEVAIKK----------VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06615    3 FEKLGEL---GAGNGGVVTKVLHRPSGLIMARklihleikpaIRNQIIRELKVLHECNSPYIVGFYGAFYSDGEISICME 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH-LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSF 312
Cdd:cd06615   80 HMDGGSLDQVLKKAGRIPENILGKISIAVLRGLTYLReKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSF 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE--IPYKDVDSSAIIWGVGSNSLHLPVPSTCPDG 380
Cdd:cd06615  159 VGTRSYMSPERLQGTHYTVQSDIWSLGLSLVEMAIGRypIPPPDAKELEAMFGRPVSEGEAKESHRPVSG 228
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
173-354 3.57e-27

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 111.62  E-value: 3.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQNETD----------IKHLRKLKHPNIIAF-KGVCTQAPCYcIIMEYCAHGQ 239
Cdd:cd14162    8 LGHGSYAVVKKAYSTkhKCKVAIKIVSKKKAPEdylqkflpreIEVIKGLKHPNLICFyEAIETTSRVY-IIMELAENGD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMS--FAG 314
Cdd:cd14162   87 LLDYIRKNGALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFARgvmKTKDGKPKLSetYCG 166
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755554055 315 TVAWMAPEVIRNEPVSEKV-DIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14162  167 SYAYASPEILRGIPYDPFLsDIWSMGVVLYTMVYGRLPFDD 207
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
173-405 3.67e-27

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 111.58  E-value: 3.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAV--FLGKFRAEEVAIK-----KVR-----EQN-ETDIKHLRKLKHPNIIAFKGVCT---QAPCYcIIMEYCA 236
Cdd:cd14119    1 LGEGSYGKVkeVLDTETLCRRAVKilkkrKLRripngEANvKREIQILRRLNHRNVIKLVDVLYneeKQKLY-MVMEYCV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRL--------LVDwstgiasGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS---D 305
Cdd:cd14119   80 GGLQEMLDSAPDKRLPIWqahgyfvqLID-------GLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEALDlfaE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGTVAWMAPEVIR-NEPVSE-KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHlpVPSTCPDGFKI 383
Cdd:cd14119  153 DDTCTTSQGSPAFQPPEIANgQDSFSGfKVDIWSAGVTLYNMTTGKYPFEGDNIYKLFENIGKGEYT--IPDDVDPDLQD 230
                        250       260
                 ....*....|....*....|..
gi 755554055 384 LMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14119  231 LLRGMLEKDPEKRFTIEQIRQH 252
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
163-405 3.98e-27

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 112.51  E-value: 3.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06655   17 PKKKYTRYEKIGQGASGTVFTAIDVAtgQEVAIKQINLQKQpkkeliiNEILVMKELKNPNIVNFLDSFLVGDELFVVME 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASgMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKSTKMSF 312
Cdd:cd06655   97 YLAGGSLTDVVTETCMDEAQIAAVCRECLQA-LEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITpEQSKRSTM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLPVPSTCPDGFKILMKQTWQS 391
Cdd:cd06655  176 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgTPELQNPEKLSPIFRDFLNRCLEM 255
                        250
                 ....*....|....
gi 755554055 392 KPRNRPSFRQTLMH 405
Cdd:cd06655  256 DVEKRGSAKELLQH 269
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
173-346 5.89e-27

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 111.60  E-value: 5.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKK--VREQ----NETDIKHLRKLKHPNIIAF-------KGVCTQapcYCIIMEYCAHGQ 239
Cdd:cd14056    3 IGKGRYGEVWLGKYRGEKVAVKIfsSRDEdswfRETEIYQTVMLRHENILGFiaadiksTGSWTQ---LWLITEYHEHGS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAgRKITPRLLVDWSTGIASGMNYLH--LH------KIIHRDLKSPNVLVTHTDAVKISDFG--TSKELSDKSTK 309
Cdd:cd14056   80 LYDYLQR-NTLDTEEALRLAYSAASGLAHLHteIVgtqgkpAIAHRDLKSKNILVKRDGTCCIADLGlaVRYDSDTNTID 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 310 MSF---AGTVAWMAPEVIRN--EPVS----EKVDIWSFGVVLWELL 346
Cdd:cd14056  159 IPPnprVGTKRYMAPEVLDDsiNPKSfesfKMADIYSFGLVLWEIA 204
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
173-347 6.45e-27

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 110.98  E-value: 6.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKfRAE--------EVAIKKVRE------QNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd08221    8 LGRGAFGEAVLYR-KTEdnslvvwkEVNLSRLSEkerrdaLNEIDI--LSLLNHDNIITYYNHFLDGESLFIEMEYCNGG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYE-VLRAGRKITPRLLVDWST-GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGT 315
Cdd:cd08221   85 NLHDkIAQQKNQLFPEEVVLWYLyQIVSAVSHIHKAGILHRDIKTLNIFLTKADLVKLGDFGISKVLDSESSMAeSIVGT 164
                        170       180       190
                 ....*....|....*....|....*....|..
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT 347
Cdd:cd08221  165 PYYMSPELVQGVKYNFKSDIWAVGCVLYELLT 196
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
173-356 7.31e-27

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 112.31  E-value: 7.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKVRE----QNEtDI------KHLRKL--KHPNIIAFKGvCTQAPCY-CIIMEYCAH 237
Cdd:cd05570    3 LGKGSFGKVMLAERKKTDelYAIKVLKKeviiEDD-DVectmteKRVLALanRHPFLTGLHA-CFQTEDRlYFVMEYVNG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQL-YEVLRAGRKITPRLlVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGT 315
Cdd:cd05570   81 GDLmFHIQRARRFTEERA-RFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKEgIWGGNTTSTFCGT 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05570  160 PDYIAPEILREQDYGFSVDWWALGVLLYEMLAGQSPFEGDD 200
PTKc_Mer cd14204
Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the ...
173-407 1.05e-26

Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Mer (or Mertk) is named after its original reported expression pattern (monocytes, epithelial, and reproductive tissues). It is required for the ingestion of apoptotic cells by phagocytes such as macrophages, retinal pigment epithelial cells, and dendritic cells. Mer is also important in maintaining immune homeostasis. Mer is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Mer subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271106 [Multi-domain]  Cd Length: 284  Bit Score: 111.18  E-value: 1.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-----VAIKKVREQN--ETDIKH-------LRKLKHPNIIAFKGVCT-----QAPCYCIIME 233
Cdd:cd14204   15 LGEGEFGSVMEGELQQPDgtnhkVAVKTMKLDNfsQREIEEflseaacMKDFNHPNVIRLLGVCLevgsqRIPKPMVILP 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGR-----KITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL---- 303
Cdd:cd14204   95 FMKYGDLHSFLLRSRlgsgpQHVPlQTLLKFMIDIALGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIysgd 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 ---SDKSTKMSfagtVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAiIWGVGSNSLHLPVPSTCPD 379
Cdd:cd14204  175 yyrQGRIAKMP----VKWIAVESLADRVYTVKSDVWAFGVTMWEIATrGMTPYPGVQNHE-IYDYLLHGHRLKQPEDCLD 249
                        250       260
                 ....*....|....*....|....*...
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14204  250 ELYDIMYSCWRSDPTDRPTFTQLRENLE 277
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
173-399 1.22e-26

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 110.28  E-value: 1.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK-------KVREQNE--TDIKHLRKLKHPNIIAFKGVCTQApcYCIIMEYCAHGQLy 241
Cdd:cd14025    4 VGSGGFGQVYKVRHKHwkTWLAIKcppslhvDDSERMEllEEAKKMEMAKFRHILPVYGICSEP--VGLVMEYMETGSL- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGTSK--ELSdKSTKMS---FAG 314
Cdd:cd14025   81 EKLLASEPLPWELRFRIIHETAVGMNFLHCMKppLLHLDLKPANILLDAHYHVKISDFGLAKwnGLS-HSHDLSrdgLRG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIR--NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS--SAIIWGVGSNSLHLPV-----PSTCpDGFKILM 385
Cdd:cd14025  160 TIAYLPPERFKekNRCPDTKHDVYSFAIVIWGILTQKKPFAGENNilHIMVKVVKGHRPSLSPiprqrPSEC-QQMICLM 238
                        250
                 ....*....|....
gi 755554055 386 KQTWQSKPRNRPSF 399
Cdd:cd14025  239 KRCWDQDPRKRPTF 252
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
173-401 1.23e-26

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 110.29  E-value: 1.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE-EVAIKK--VREQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd14154    1 LGKGFFGQAIKVTHRETgEVMVMKelIRFDEEAqrnflkEVKVMRSLDHPNVLKFIGVLYKDKKLNLITEYIPGGTLKDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGRKITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---------KSTKMSFA 313
Cdd:cd14154   81 LKDMARPLPwAQRVRFAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARLIVEerlpsgnmsPSETLRHL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 ------------GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtGEIpYKDVD--SSAIIWGVGSNSLHLPVPSTCPD 379
Cdd:cd14154  161 kspdrkkrytvvGNPYWMAPEMLNGRSYDEKVDIFSFGIVLCEII-GRV-EADPDylPRTKDFGLNVDSFREKFCAGCPP 238
                        250       260
                 ....*....|....*....|..
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd14154  239 PFFKLAFLCCDLDPEKRPPFET 260
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
186-420 1.30e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 110.97  E-value: 1.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 186 FRAEEVAIKKVREQN----ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAgRKITPRllVDWS-- 259
Cdd:cd14086   29 FAAKIINTKKLSARDhqklEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA-REFYSE--ADAShc 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 -TGIASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKELS-DKSTKMSFAGTVAWMAPEVIRNEPVSEKVD 334
Cdd:cd14086  106 iQQILESVNHCHQNGIVHRDLKPENLLLASKSkgaAVKLADFGLAIEVQgDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 335 IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP--STCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASAD 412
Cdd:cd14086  186 IWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPewDTVTPEAKDLINQMLTVNPAKRITAAEALKHPWICQRD 265
                        250
                 ....*....|.
gi 755554055 413 VLATP---QET 420
Cdd:cd14086  266 RVASMvhrQET 276
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
185-355 1.46e-26

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 110.95  E-value: 1.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 185 KFRAEEVAIKKVREQNETDIkhLRKLKHPNIIAFKGVcTQAP--CYCIIMEYCaHGQLYEVLRAGRKITPR-------LL 255
Cdd:cd14001   39 KCDKGQRSLYQERLKEEAKI--LKSLNHPNIVGFRAF-TKSEdgSLCLAMEYG-GKSLNDLIEERYEAGLGpfpaatiLK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 256 VDWStgIASGMNYLHLHK-IIHRDLKSPNVLVTHT-DAVKISDFGTSKELS-----DKSTKMSFAGTVAWMAPEVI-RNE 327
Cdd:cd14001  115 VALS--IARALEYLHNEKkILHGDIKSGNVLIKGDfESVKLCDFGVSLPLTenlevDSDPKAQYVGTEPWKAKEALeEGG 192
                        170       180
                 ....*....|....*....|....*...
gi 755554055 328 PVSEKVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd14001  193 VITDKADIFAYGLVLWEMMTLSVPHLNL 220
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
169-407 1.52e-26

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 110.39  E-value: 1.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGK---FRAEeVAIKKV--------REQN----ETDIKHLRKLKHpnIIAFKGVCTQAPCYCIIME 233
Cdd:cd14026    1 DLRYLSRGAFGTVSRARhadWRVT-VAIKCLkldspvgdSERNcllkEAEILHKARFSY--ILPILGICNEPEFLGIVTE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRaGRKITP--------RLLVDwstgIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGTSK-- 301
Cdd:cd14026   78 YMTNGSLNELLH-EKDIYPdvawplrlRILYE----IALGVNYLHNMSppLLHHDLKTQNILLDGEFHVKIADFGLSKwr 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ----ELSDKSTKMSFAGTVAWMAPEviRNEP-----VSEKVDIWSFGVVLWELLTGEIPYKDV-DSSAIIWGV------- 364
Cdd:cd14026  153 qlsiSQSRSSKSAPEGGTIIYMPPE--EYEPsqkrrASVKHDIYSYAIIMWEVLSRKIPFEEVtNPLQIMYSVsqghrpd 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 755554055 365 -GSNSLHLPVPSTcpDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14026  231 tGEDSLPVDIPHR--ATLINLIESGWAQNPDERPSFLKCLIELE 272
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
173-355 1.58e-26

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 110.38  E-value: 1.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIK---K---VREQ------NETDIkhLRKLKHPNIIafKGVCT---QAPCYcIIMEYC 235
Cdd:cd05581    9 LGEGSYSTVVLAKEKEtgKEYAIKvldKrhiIKEKkvkyvtIEKEV--LSRLAHPGIV--KLYYTfqdESKLY-FVLEYA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRagrKITpRLLVDWSTGIAS----GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST--- 308
Cdd:cd05581   84 PNGDLLEYIR---KYG-SLDEKCTRFYTAeivlALEYLHSKGIIHRDLKPENILLDEDMHIKITDFGTAKVLGPDSSpes 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554055 309 ---------------KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd05581  160 tkgdadsqiaynqarAASFVGTAEYVSPELLNEKPAGKSSDLWALGCIIYQMLTGKPPFRGS 221
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
173-396 2.07e-26

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 109.62  E-value: 2.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV--AIKKVREQN--ETDI-KH-------LRKLKHPNIIAFkgVCT---QAPCYcIIMEYCAH 237
Cdd:cd05572    1 LGVGGFGRVELVQLKSKGRtfALKCVKKRHivQTRQqEHifsekeiLEECNSPFIVKL--YRTfkdKKYLY-MLMEYCLG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAgrkitpRLLVDWSTG------IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS 311
Cdd:cd05572   78 GELWTILRD------RGLFDEYTArfytacVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGRKTWT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS------AIIWGVGsnslHLPVPSTCPDGFKILM 385
Cdd:cd05572  152 FCGTPEYVAPEIILNKGYDFSVDYWSLGILLYELLTGRPPFGGDDEDpmkiynIILKGID----KIEFPKYIDKNAKNLI 227
                        250
                 ....*....|.
gi 755554055 386 KQTWQSKPRNR 396
Cdd:cd05572  228 KQLLRRNPEER 238
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
173-406 2.18e-26

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 109.66  E-value: 2.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQG-AVFLGKFRAEEVAIKK--VREQNET------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd14221    1 LGKGCFGqAIKVTHRETGEVMVMKelIRFDEETqrtflkEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGRKITP-RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL---------------SDKS 307
Cdd:cd14221   81 IKSMDSHYPwSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMvdektqpeglrslkkPDRK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNS-LHLPVPSTCPDGFKILMK 386
Cdd:cd14221  161 KRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGfLDRYCPPNCPPSFFPIAV 240
                        250       260
                 ....*....|....*....|....*..
gi 755554055 387 QTWQSKPRNRPSFRQ-------TLMHL 406
Cdd:cd14221  241 LCCDLDPEKRPSFSKlehwletLRMHL 267
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
173-401 2.39e-26

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 110.13  E-value: 2.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGK---FRAEE----VAIKKVREQNET-------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05093   13 LGEGAFGKVFLAEcynLCPEQdkilVAVKTLKDASDNarkdfhrEAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAG-------------RKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSd 305
Cdd:cd05093   93 DLNKFLRAHgpdavlmaegnrpAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 kSTKMSFAG-----TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPSTCPD 379
Cdd:cd05093  172 -STDYYRVGghtmlPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTyGKQPWYQLSNNEVIECITQGRV-LQRPRTCPK 249
                        250       260
                 ....*....|....*....|..
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05093  250 EVYDLMLGCWQREPHMRLNIKE 271
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
173-440 2.43e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 110.08  E-value: 2.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQN-------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE- 242
Cdd:cd14166   11 LGSGAFSEVYLVKQRStgKLYALKCIKKSPlsrdsslENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDr 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAG---RKITPRLLvdwsTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKeLSDKSTKMSFAGTV 316
Cdd:cd14166   91 ILERGvytEKDASRVI----NQVLSAVKYLHENGIVHRDLKPENLLYLTPDensKIMITDFGLSK-MEQNGIMSTACGTP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSTCPDGFKILMKQTWQSKPR 394
Cdd:cd14166  166 GYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESRLFEKIkeGYYEFESPFWDDISESAKDFIRHLLEKNPS 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 395 NRPSFRQTLMHLDIASADVLatpQETYFKSQAewrEEVKKHFEKIK 440
Cdd:cd14166  246 KRYTCEKALSHPWIIGNTAL---HRDIYPSVS---EQIQKNFAKSK 285
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
174-345 2.83e-26

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 109.84  E-value: 2.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQGAVFLGKFRAEEVAIK--KVRE----QNETDIKHLRKLKHPNIIAF-------KGVCTQapcYCIIMEYCAHGQL 240
Cdd:cd13998    4 GKGRFGEVWKASLKNEPVAVKifSSRDkqswFREKEIYRTPMLKHENILQFiaaderdTALRTE---LWLVTAFHPNGSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRaGRKITPRLLVDWSTGIASGMNYLHL-------HK--IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS 311
Cdd:cd13998   81 *DYLS-LHTIDWVSLCRLALSVARGLAHLHSeipgctqGKpaIAHRDLKSKNILVKNDGTCCIADFGLAVRLSPSTGEED 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 312 FA-----GTVAWMAPEVI------RNEPVSEKVDIWSFGVVLWEL 345
Cdd:cd13998  160 NAnngqvGTKRYMAPEVLegainlRDFESFKRVDIYAMGLVLWEM 204
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
173-372 3.38e-26

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 110.44  E-value: 3.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL------GKFRAEEVAIKKV----REQNETDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd05603    3 IGKGSFGKVLLakrkcdGKFYAVKVLQKKTilkkKEQNHIMAERnvlLKNLKHPFLVGLHYSFQTSEKLYFVLDYVNGGE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 L-YEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVA 317
Cdd:cd05603   83 LfFHLQRERCFLEPRARF-YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEgMEPEETTSTFCGTPE 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372
Cdd:cd05603  162 YLAPEVLRKEPYDRTVDWWCLGAVLYEMLYGLPPFYSRDVSQMYDNILHKPLHLP 216
PK_GC_unk cd14045
Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The ...
184-401 4.11e-26

Pseudokinase domain of the unknown subfamily of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270947 [Multi-domain]  Cd Length: 269  Bit Score: 108.79  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAIKKVREQNET-------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLragrkITPRLLV 256
Cdd:cd14045   26 GIYDGRTVAIKKIAKKSFTlskrirkEVKQVRELDHPNLCKFIGGCIEVPNVAIITEYCPKGSLNDVL-----LNEDIPL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWS------TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS----KELSDKSTKMSFAGTVAWMAPEvIRN 326
Cdd:cd14045  101 NWGfrfsfaTDIARGMAYLHQHKIYHGRLKSSNCVIDDRWVCKIADYGLTtyrkEDGSENASGYQQRLMQVYLPPE-NHS 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 327 EP---VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAiiwgvgSNSLHLPVPS----------TCPDGFKILMKQTWQSKP 393
Cdd:cd14045  180 NTdtePTQATDVYSYAIILLEIATRNDPVPEDDYSL------DEAWCPPLPElisgktenscPCPADYVELIRRCRKNNP 253

                 ....*...
gi 755554055 394 RNRPSFRQ 401
Cdd:cd14045  254 AQRPTFEQ 261
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
173-360 6.27e-26

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 109.06  E-value: 6.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE----VAIKKVRE----------QNETDIkhLRKLKHPNIIafKGVCTQAPCYCI--IMEYCA 236
Cdd:cd05612    9 IGTGTFGRVHLVRDRISEhyyaLKVMAIPEvirlkqeqhvHNEKRV--LKEVSHPFII--RLFWTEHDQRFLymLMEYVP 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMsfAGTV 316
Cdd:cd05612   85 GGELFSYLRNSGRFSNSTGLFYASEIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKLRDRTWTL--CGTP 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 360
Cdd:cd05612  163 EYLAPEVIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGI 206
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
173-425 6.80e-26

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 109.71  E-value: 6.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL------GKFRA-----EEVAIKKVR-EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd05595    3 LGKGTFGKVILvrekatGRYYAmkilrKEVIIAKDEvAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGEL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVAWM 319
Cdd:cd05595   83 FFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEgITDGATMKTFCGTPEYL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 320 APEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPvPSTCPDGfKILMKQTWQSKPRNR--- 396
Cdd:cd05595  163 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP-RTLSPEA-KSLLAGLLKKDPKQRlgg 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 755554055 397 -PS-FRQTLMH---LDIASADVLATPQETYFKSQ 425
Cdd:cd05595  241 gPSdAKEVMEHrffLSINWQDVVQKKLLPPFKPQ 274
STKc_KSR1 cd14152
Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the ...
166-406 8.62e-26

Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KSR1 functions as a transducer of TNFalpha-stimulated C-Raf activation of ERK1/2 and NF-kB. Detected activity of KSR1 is cell type specific and context dependent. It is inactive in normal colon epithelial cells and becomes activated at the onset of inflammatory bowel disease (IBD). Similarly, KSR1 activity is undetectable prior to stimulation by EGF or ceramide in COS-7 or YAMC cells, respectively. KSR proteins are widely regarded as pseudokinases, however, this matter is up for debate as catalytic activity has been detected for KSR1 in some systems. The KSR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271054 [Multi-domain]  Cd Length: 279  Bit Score: 108.13  E-value: 8.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELqwLGSGAQGAVFLGKFRAEeVAIK--KVREQNETDIK-------HLRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd14152    3 ELGEL--IGQGRWGKVHRGRWHGE-VAIRllEIDGNNQDHLKlfkkevmNYRQTRHENVVLFMGACMHPPHLAIITSFCK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRagrkiTPRLLVDW------STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVkISDFG-------TSKEL 303
Cdd:cd14152   80 GRTLYSFVR-----DPKTSLDInktrqiAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVV-ITDFGlfgisgvVQEGR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 SDKSTKMSfAGTVAWMAPEVIRNE---------PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP 374
Cdd:cd14152  154 RENELKLP-HDWLCYLAPEIVREMtpgkdedclPFSKAADVYAFGTIWYELQARDWPLKNQPAEALIWQIGSGEGMKQVL 232
                        250       260       270
                 ....*....|....*....|....*....|....
gi 755554055 375 STCPDGFKI--LMKQTWQSKPRNRPSFRQtLMHL 406
Cdd:cd14152  233 TTISLGKEVteILSACWAFDLEERPSFTL-LMDM 265
PTKc_TrkC cd05094
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze ...
173-401 1.15e-25

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkC is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkC to its ligand, neurotrophin 3 (NT3), results in receptor oligomerization and activation of the catalytic domain. TrkC is broadly expressed in the nervous system and in some non-neural tissues including the developing heart. NT3/TrkC signaling plays an important role in the innervation of the cardiac conducting system and the development of smooth muscle cells. Mice deficient with NT3 and TrkC have multiple heart defects. NT3/TrkC signaling is also critical for the development and maintenance of enteric neurons that are important for the control of gut peristalsis. The TrkC subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270676 [Multi-domain]  Cd Length: 287  Bit Score: 108.17  E-value: 1.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE-------VAIKKVREQN-------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05094   13 LGEGAFGKVFLAECYNLSptkdkmlVAVKTLKDPTlaarkdfQREAELLTNLQHDHIVKFYGVCGDGDPLIMVFEYMKHG 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAgRKITPRLLVDW-----------------STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK 301
Cdd:cd05094   93 DLNKFLRA-HGPDAMILVDGqprqakgelglsqmlhiATQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPSTC 377
Cdd:cd05094  172 DVYSTDYYRVGGHTmlpIRWMPPESIMYRKFTTESDVWSFGVILWEIFTyGKQPWFQLSNTEVIECITQGRV-LERPRVC 250
                        250       260
                 ....*....|....*....|....
gi 755554055 378 PDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05094  251 PKEVYDIMLGCWQREPQQRLNIKE 274
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
173-352 1.44e-25

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 107.70  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIK--------KVREQNETDIKHLRKLKHPNIIAFKGV-------CTQAPCycIIMEYC 235
Cdd:cd14039    1 LGTGGFGNVCLYQNQetGEKIAIKscrlelsvKNKDRWCHEIQIMKKLNHPNVVKACDVpeemnflVNDVPL--LAMEYC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLR-----AGRKITP--RLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV---KISDFGTSKELSD 305
Cdd:cd14039   79 SGGDLRKLLNkpencCGLKESQvlSLLSD----IGSGIQYLHENKIIHRDLKPENIVLQEINGKivhKIIDLGYAKDLDQ 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 306 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14039  155 GSLCTSFVGTLQYLAPELFENKSYTVTVDYWSFGTMVFECIAGFRPF 201
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
173-405 1.47e-25

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 107.36  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGA-VFLGKFRAEEVAIKKV---------REqnetdIKHLRKL-KHPNIIAfkgvctqapCYC---------IIM 232
Cdd:cd13982    9 LGYGSEGTiVFRGTFDGRPVAVKRLlpeffdfadRE-----VQLLRESdEHPNVIR---------YFCtekdrqflyIAL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAhGQLYEVLRAGRKIT---------PRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDA-----VKISDFG 298
Cdd:cd13982   75 ELCA-ASLQDLVESPRESKlflrpglepVRLLRQ----IASGLAHLHSLNIVHRDLKPQNILISTPNAhgnvrAMISDFG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 TSKELSDK----STKMSFAGTVAWMAPEVIRNEP---VSEKVDIWSFGVVLWELLT-GEIPYKD--VDSSAIIWGVGSNS 368
Cdd:cd13982  150 LCKKLDVGrssfSRRSGVAGTSGWIAPEMLSGSTkrrQTRAVDIFSLGCVFYYVLSgGSHPFGDklEREANILKGKYSLD 229
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 755554055 369 LHLPVPSTCPDGfKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd13982  230 KLLSLGEHGPEA-QDLIERMIDFDPEKRPSAEEVLNH 265
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
173-352 1.51e-25

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 108.26  E-value: 1.51e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL---------GKFRAEEVAIK-------KVREQNETDIkhLRKLKHPNII----AFKgvcTQAPCYcIIM 232
Cdd:cd05582    3 LGQGSFGKVFLvrkitgpdaGTLYAMKVLKKatlkvrdRVRTKMERDI--LADVNHPFIVklhyAFQ---TEGKLY-LIL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-S 311
Cdd:cd05582   77 DFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHEKKAyS 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05582  157 FCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPF 197
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
173-405 1.85e-25

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 106.58  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR------AEEVAIKK------VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14116   13 LGKGKFGNVYLAREKqskfilALKVLFKAqlekagVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKElSDKSTKMSFAGTVAWMA 320
Cdd:cd14116   93 YRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVH-APSSRRTTLCGTLDYLP 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 321 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYkDVDSSAIIWGVGSNsLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd14116  172 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETYKRISR-VEFTFPDFVTEGARDLISRLLKHNPSQRPMLR 249

                 ....*
gi 755554055 401 QTLMH 405
Cdd:cd14116  250 EVLEH 254
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
175-361 1.96e-25

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 106.92  E-value: 1.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 175 SGAQGAVFLGKFRAEE--VAIKKVREQN------------ETDIkhLRKLKHPNII----AFKGVCTqapcYCIIMEYCA 236
Cdd:cd05579    3 RGAYGRVYLAKKKSTGdlYAIKVIKKRDmirknqvdsvlaERNI--LSQAQNPFVVklyySFQGKKN----LYLVMEYLP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLR--------AGRKITPRLLVdwstgiasGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKS 307
Cdd:cd05579   77 GGDLYSLLEnvgaldedVARIYIAEIVL--------ALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGLSKVgLVRRQ 148
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 308 TKMSFA---------------GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDvDSSAII 361
Cdd:cd05579  149 IKLSIQkksngapekedrrivGTPDYLAPEILLGQGHGKTVDWWSLGVILYEFLVGIPPFHA-ETPEEI 216
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
173-405 2.30e-25

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 106.70  E-value: 2.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--------------KFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQ--APCYCIIMEYCA 236
Cdd:cd06651   15 LGQGAFGRVYLCydvdtgrelaakqvQFDPESPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDraEKTLTIFMEYMP 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD---KSTKM-SF 312
Cdd:cd06651   95 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTicmSGTGIrSV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWqSK 392
Cdd:cd06651  175 TGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHARDFLGCIF-VE 253
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd06651  254 ARHRPSAEELLRH 266
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
173-356 2.50e-25

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 107.83  E-value: 2.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVR-----EQNE-----TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd05571    3 LGKGTFGKVILCREKAtgELYAIKILKkeviiAKDEvahtlTENRVLQNTRHPFLTSLKYSFQTNDRLCFVMEYVNGGEL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVAWM 319
Cdd:cd05571   83 FFHLSRERVFSEDRTRFYGAEIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKEeISYGATTKTFCGTPEYL 162
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 320 APEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05571  163 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNRD 199
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
179-347 2.84e-25

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 107.03  E-value: 2.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 179 GAVFLGKFRAEEVAIKKVREQ------NETDIKHLRKLKHPNIIAFKGV--CTQA--PCYCIIMEYCAHGQLYEVLRaGR 248
Cdd:cd14053    9 GAVWKAQYLNRLVAVKIFPLQekqswlTEREIYSLPGMKHENILQFIGAekHGESleAEYWLITEFHERGSLCDYLK-GN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 249 KITPRLLVDWSTGIASGMNYLH--------LHK--IIHRDLKSPNVLVTHTDAVKISDFG------TSKELSDKSTKMsf 312
Cdd:cd14053   88 VISWNELCKIAESMARGLAYLHedipatngGHKpsIAHRDFKSKNVLLKSDLTACIADFGlalkfePGKSCGDTHGQV-- 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755554055 313 aGTVAWMAPEVIR-----NEPVSEKVDIWSFGVVLWELLT 347
Cdd:cd14053  166 -GTRRYMAPEVLEgainfTRDAFLRIDMYAMGLVLWELLS 204
PK_KSR2 cd14153
Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to ...
166-407 3.37e-25

Pseudokinase domain of Kinase Suppressor of Ras 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR2 interacts with the protein phosphatase calcineurin and functions in calcium-mediated ERK signaling. It also functions in energy metabolism by regulating AMP kinase and AMPK-dependent processes such as glucose uptake and fatty acid oxidation. KSR proteins act as scaffold proteins that function downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases. The KSR2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271055 [Multi-domain]  Cd Length: 270  Bit Score: 106.25  E-value: 3.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELqwLGSGAQGAVFLGKFRAEeVAIK--KVREQNETDIKHL-------RKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd14153    3 EIGEL--IGKGRFGQVYHGRWHGE-VAIRliDIERDNEEQLKAFkrevmayRQTRHENVVLFMGACMSPPHLAIITSLCK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKItprLLVDWSTGIAS----GMNYLHLHKIIHRDLKSPNVLVTHTDAVkISDFGTSK-----ELSDKS 307
Cdd:cd14153   80 GRTLYSVVRDAKVV---LDVNKTRQIAQeivkGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFTisgvlQAGRRE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSF-AGTVAWMAPEVIRNE---------PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlhLPVPSTC 377
Cdd:cd14153  156 DKLRIqSGWLCHLAPEIIRQLspeteedklPFSKHSDVFAFGTIWYELHAREWPFKTQPAEAIIWQVGSGM--KPNLSQI 233
                        250       260       270
                 ....*....|....*....|....*....|..
gi 755554055 378 PDGFKI--LMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14153  234 GMGKEIsdILLFCWAYEQEERPTFSKLMEMLE 265
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
173-352 3.53e-25

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 106.59  E-value: 3.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL--GKFRAEEVAIKKVREQNET--------DIKHLRKLKHPNIIAFK----GVCTQAP--CYCIIMEYCA 236
Cdd:cd14038    2 LGTGGFGNVLRwiNQETGEQVAIKQCRQELSPknrerwclEIQIMKRLNHPNVVAARdvpeGLQKLAPndLPLLAMEYCQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVL---------RAGRKITprLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV---KISDFGTSKELS 304
Cdd:cd14038   82 GGDLRKYLnqfenccglREGAILT--LLSD----ISSALRYLHENRIIHRDLKPENIVLQQGEQRlihKIIDLGYAKELD 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 305 DKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14038  156 QGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPF 203
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
197-374 3.80e-25

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 105.86  E-value: 3.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 197 REQNETDIKHLRKLKHPNIIAF----KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLH 272
Cdd:cd14033   44 RQRFSEEVEMLKGLQHPNIVRFydswKSTVRGHKCIILVTELMTSGTLKTYLKRFREMKLKLLQRWSRQILKGLHFLHSR 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 273 --KIIHRDLKSPNVLVTH-TDAVKISDFGTSKeLSDKSTKMSFAGTVAWMAPEVIRnEPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd14033  124 cpPILHRDLKCDNIFITGpTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCILEMATSE 201
                        170       180       190
                 ....*....|....*....|....*....|.
gi 755554055 350 IPYKDVDSSAIIW-----GVGSNSLH-LPVP 374
Cdd:cd14033  202 YPYSECQNAAQIYrkvtsGIKPDSFYkVKVP 232
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
163-405 4.49e-25

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 106.73  E-value: 4.49e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVF--LGKFRAEEVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06656   17 PKKKYTRFEKIGQGASGTVYtaIDIATGQEVAIKQMNLQQQpkkeliiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVlragrkITPRLLVDWSTGIA-----SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS 307
Cdd:cd06656   97 YLAGGSLTDV------VTETCMDEGQIAAVcreclQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpEQS 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLPVPSTCPDGFKILMK 386
Cdd:cd06656  171 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNgTPELQNPERLSAVFRDFLN 250
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd06656  251 RCLEMDVDRRGSAKELLQH 269
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
173-405 5.59e-25

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 105.04  E-value: 5.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIK----------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14079   10 LGVGSFGKVKLAEHEltGHKVAVKilnrqkikslDMEEKIRREIQILKLFRHPHIIRLYEVIETPTDIFMVMEYVSGGEL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YE-VLRAGRkitprLLVDWSTG----IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd14079   90 FDyIVQKGR-----LSEDEARRffqqIISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGLSNIMRDGEFLKTSCGS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIrnepvSEK------VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLpvPSTCPDGFKILMKQTW 389
Cdd:cd14079  165 PNYAAPEVI-----SGKlyagpeVDVWSCGVILYALLCGSLPFDDEHIPNLFKKIKSGIYTI--PSHLSPGARDLIKRML 237
                        250
                 ....*....|....*.
gi 755554055 390 QSKPRNRPSFRQTLMH 405
Cdd:cd14079  238 VVDPLKRITIPEIRQH 253
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
164-411 6.60e-25

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 105.72  E-value: 6.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFR--AEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCT-QAPCYC-- 229
Cdd:cd07840    1 YEKIAQI---GEGTYGQVYKARNKktGELVALKKIRMENEKEgfpitaireIKLLQKLDHPNVVRLKEIVTsKGSAKYkg 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 -IIM--EYCAH---GQLYevlRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 303
Cdd:cd07840   78 sIYMvfEYMDHdltGLLD---NPEVKFTESQIKCYMKQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 SDKStKMSFAGTVA--WM-APEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYK---DVDSSAIIWGV-GSnslhlPVPS 375
Cdd:cd07840  155 TKEN-NADYTNRVItlWYrPPELLLGATrYGPEVDMWSVGCILAELFTGKPIFQgktELEQLEKIFELcGS-----PTEE 228
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 376 TCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASA 411
Cdd:cd07840  229 NWPGVSDLPWFENLKPKKPYKRRLREVFKNVIDPSA 264
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
170-434 7.85e-25

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 106.59  E-value: 7.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL------GKFRAEEVAIKKV----REQNETDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd05604    1 LKVIGKGSFGKVLLakrkrdGKYYAVKVLQKKVilnrKEQKHIMAERnvlLKNVKHPFLVGLHYSFQTTDKLYFVLDFVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKIT-PRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAG 314
Cdd:cd05604   81 GGELFFHLQRERSFPePRARF-YAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEgISNSDTTTTFCG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIwgvgSNSLHLPV---PSTCPDGFKILmKQTWQS 391
Cdd:cd05604  160 TPEYLAPEVIRKQPYDNTVDWWCLGSVLYEMLYGLPPFYCRDTAEMY----ENILHKPLvlrPGISLTAWSIL-EELLEK 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 755554055 392 KPRNRPSFRQTLMHLdiasadvlatpQETYFKSQAEWREEVKK 434
Cdd:cd05604  235 DRQLRLGAKEDFLEI-----------KNHPFFESINWTDLVQK 266
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
173-405 1.06e-24

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 104.55  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV--AIKKVREQN---------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14097    9 LGQGSFGVVIEATHKETQTkwAIKKINREKagssavkllEREVDILKHVNHAHIIHLEEVFETPKRMYLVMELCEDGELK 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVL-RAG-------RKITPRLlvdwstgiASGMNYLHLHKIIHRDLKSPNVLVTHTDA-------VKISDFGTSKELSDK 306
Cdd:cd14097   89 ELLlRKGffsenetRHIIQSL--------ASAVAYLHKNDIVHRDLKLENILVKSSIIdnndklnIKVTDFGLSVQKYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKM--SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSTCPDGFK 382
Cdd:cd14097  161 GEDMlqETCGTPIYMAPEVISAHGYSQQCDIWSIGVIMYMLLCGEPPFVAKSEEKLFEEIRKGDLTFTqsVWQSVSDAAK 240
                        250       260
                 ....*....|....*....|...
gi 755554055 383 ILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14097  241 NVLQQLLKVDPAHRMTASELLDN 263
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
168-348 1.14e-24

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 105.10  E-value: 1.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 168 SELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYC 235
Cdd:cd07832    3 KILGRIGEGAHGIVFKAKDREtgETVALKKVALRKLEGgipnqalreIKALQACQgHPYVVKLRDVFPHGTGFVLVFEYM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGqLYEVLRAGRKITPRLLVD-WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM--SF 312
Cdd:cd07832   83 LSS-LSEVLRDEERPLTEAQVKrYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGLARLFSEEDPRLysHQ 161
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 313 AGTVAWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTG 348
Cdd:cd07832  162 VATRWYRAPELLYGSRkYDEGVDLWAVGCIFAELLNG 198
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
173-356 1.34e-24

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 104.03  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKV-----------REQNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCaHGQ 239
Cdd:cd14082   11 LGSGQFGIVYGGKHRktGRDVAIKVIdklrfptkqesQLRNEVAI--LQQLSHPGVVNLECMFETPERVFVVMEKL-HGD 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVL------RAGRKITpRLLVdwsTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKM 310
Cdd:cd14082   88 MLEMIlssekgRLPERIT-KFLV---TQILVALRYLHSKNIVHCDLKPENVLLASAEPfpqVKLCDFGFARIIGEKSFRR 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY-KDVD 356
Cdd:cd14082  164 SVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFnEDED 210
PTKc_Aatyk3 cd14206
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs ...
170-410 1.40e-24

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk3, also called lemur tyrosine kinase 3 (Lmtk3) is a receptor kinase containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. The function of Aatyk3 is still unknown. The Aatyk3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271108 [Multi-domain]  Cd Length: 276  Bit Score: 104.65  E-value: 1.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGK----FRAEEVAIKKVR------EQNE--TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd14206    2 LQEIGNGWFGKVILGEifsdYTPAQVVVKELRvsagplEQRKfiSEAQPYRSLQHPNILQCLGLCTETIPFLLIMEFCQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRK---ITPRLLV-DWST------GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGtskeLSDKS 307
Cdd:cd14206   82 GDLKRYLRAQRKadgMTPDLPTrDLRTlqrmayEITLGLLHLHKNNYIHSDLALRNCLLTSDLTVRIGDYG----LSHNN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGT-------VAWMAPEVIRN-------EPVSEKVDIWSFGVVLWELLT-GEIPYKDV-DSSAIIWGVGSNSLHL 371
Cdd:cd14206  158 YKEDYYLTpdrlwipLRWVAPELLDElhgnlivVDQSKESNVWSLGVTIWELFEfGAQPYRHLsDEEVLTFVVREQQMKL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 755554055 372 PVPS---TCPDGFKILMKQTWQSkPRNRPSFRQtlMHLDIAS 410
Cdd:cd14206  238 AKPRlklPYADYWYEIMQSCWLP-PSQRPSVEE--LHLQLSY 276
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
163-417 1.42e-24

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 105.19  E-value: 1.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNE-------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06654   18 PKKKYTRFEKIGQGASGTVYTAMDVAtgQEVAIRQMNLQQQpkkeliiNEILVMRENKNPNIVNYLDSYLVGDELWVVME 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVlragrkITPRLLVDWSTGIA-----SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKS 307
Cdd:cd06654   98 YLAGGSLTDV------VTETCMDEGQIAAVcreclQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITpEQS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 308 TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLPVPSTCPDGFKILMK 386
Cdd:cd06654  172 KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNgTPELQNPEKLSAIFRDFLN 251
                        250       260       270
                 ....*....|....*....|....*....|...
gi 755554055 387 QTWQSKPRNRPSFRQTLMH--LDIASADVLATP 417
Cdd:cd06654  252 RCLEMDVEKRGSAKELLQHqfLKIAKPLSSLTP 284
PK_ILK cd14057
Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to ...
172-403 1.82e-24

Pseudokinase domain of Integrin Linked Kinase; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. ILK contains N-terminal ankyrin repeats, a Pleckstrin Homology (PH) domain, and a C-terminal pseudokinase domain. It is a component of the IPP (ILK/PINCH/Parvin) complex that couples beta integrins to the actin cytoskeleton, and plays important roles in cell adhesion, spreading, invasion, and migration. ILK was initially thought to be an active kinase despite the lack of key conserved residues because of in vitro studies showing that it can phosphorylate certain protein substrates. However, in vivo experiments in Caenorhabditis elegans, Drosophila melanogaster, and mice (ILK-null and knock-in) proved that ILK is not an active kinase. In addition to actin cytoskeleton regulation, ILK also influences the microtubule network and mitotic spindle orientation. The pseudokinase domain of ILK binds several adaptor proteins including the parvins and paxillin. The ILK subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270959 [Multi-domain]  Cd Length: 251  Bit Score: 103.72  E-value: 1.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 172 WLGSGAQGAVFLGKFRAEEVAIKKVREQNEtDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKIT 251
Cdd:cd14057   12 WKGRWQGNDIVAKILKVRDVTTRISRDFNE-EYPRLRIFSHPNVLPVLGACNSPPNLVVISQYMPYGSLYNVLHEGTGVV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 252 --PRLLVDWSTGIASGMNYLH-LHKIIHR-DLKSPNVLVTHTDAVKISdfgtskeLSDksTKMSF-----AGTVAWMAPE 322
Cdd:cd14057   91 vdQSQAVKFALDIARGMAFLHtLEPLIPRhHLNSKHVMIDEDMTARIN-------MAD--VKFSFqepgkMYNPAWMAPE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 323 VIRNEPVS---EKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSF 399
Cdd:cd14057  162 ALQKKPEDinrRSADMWSFAILLWELVTREVPFADLSNMEIGMKIALEGLRVTIPPGISPHMCKLMKICMNEDPGKRPKF 241

                 ....
gi 755554055 400 RQTL 403
Cdd:cd14057  242 DMIV 245
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
170-352 2.10e-24

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 103.74  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFlgKFRAEE-----VAIKKV--------REQNETD---------IKHLR-KLKHPNIIAFKGVCTQAP 226
Cdd:cd08528    5 LELLGSGAFGCVY--KVRKKSngqtlLALKEInmtnpafgRTEQERDksvgdiiseVNIIKeQLRHPNIVRYYKTFLEND 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEY---CAHGQLYEVLR-AGRKITPRLLVDWSTGIASGMNYLHLHK-IIHRDLKSPNVLVTHTDAVKISDFGTSK 301
Cdd:cd08528   83 RLYIVMELiegAPLGEHFSSLKeKNEHFTEDRIWNIFVQMVLALRYLHKEKqIVHRDLKPNNIMLGEDDKVTITDFGLAK 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755554055 302 ELSDKSTKM-SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd08528  163 QKGPESSKMtSVVGTILYSCPEIVQNEPYGEKADIWALGCILYQMCTLQPPF 214
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
158-405 2.50e-24

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 104.30  E-value: 2.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVpfeeiseLQWLGSGAQGAVFL------GKFRAEEV--AIKKVREQNETDIKHLRKL-KHPNIIAFKGVCTQAPCY 228
Cdd:cd06639   22 DTWDI-------IETIGKGTYGKVYKvtnkkdGSLAAVKIldPISDVDEEIEAEYNILRSLpNHPNVVKFYGMFYKADQY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 C-----IIMEYCAHGQLYE----VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT 299
Cdd:cd06639   95 VggqlwLVLELCNGGSVTElvkgLLKCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 300 SKEL-SDKSTKMSFAGTVAWMAPEVIRNE-----PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN-SLHLP 372
Cdd:cd06639  175 SAQLtSARLRRNTSVGTPFWMAPEVIACEqqydySYDARCDVWSLGITAIELADGDPPLFDMHPVKALFKIPRNpPPTLL 254
                        250       260       270
                 ....*....|....*....|....*....|...
gi 755554055 373 VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06639  255 NPEKWCRGFSHFISQCLIKDFEKRPSVTHLLEH 287
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
170-356 2.85e-24

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 105.55  E-value: 2.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL------GKFRAEEVAIKKVREQNE------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd05593   20 LKLLGKGTFGKVILvrekasGKYYAMKILKKEVIIAKDevahtlTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTV 316
Cdd:cd05593  100 GELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEgITDAATMKTFCGTP 179
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05593  180 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 219
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
173-405 3.49e-24

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 103.81  E-value: 3.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD------------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCaHG 238
Cdd:cd07841    8 LGEGTYAVVYKARDKEtgRIVAIKKIKLGERKEakdginftalreIKLLQELKHPNIIGLLDVFGHKSNINLVFEFM-ET 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKI-TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF-AGTV 316
Cdd:cd07841   87 DLEKVIKDKSIVlTPADIKSYMLMTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARSFGSPNRKMTHqVVTR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVI---RNEPVSekVDIWSFGVVLWELLTGeIPY----KDVDSSAIIWGV----------GSNSLHLPV---PST 376
Cdd:cd07841  167 WYRAPELLfgaRHYGVG--VDMWSVGCIFAELLLR-VPFlpgdSDIDQLGKIFEAlgtpteenwpGVTSLPDYVefkPFP 243
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 755554055 377 CPDGFKI----------LMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd07841  244 PTPLKQIfpaasddaldLLQRLLTLNPNKRITARQALEH 282
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
164-405 3.57e-24

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 103.51  E-value: 3.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEE--VAIKKVREQNETD------------IKHLRKLKHPNIIAFKGVC------T 223
Cdd:cd07838    1 YEEVAEI---GEGAYGTVYKARDLQDGrfVALKKVRVPLSEEgiplstireialLKQLESFEHPNVVRLLDVChgprtdR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 QAPCYcIIMEYC---AHGQLYEVLRAGrkITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd07838   78 ELKLT-LVFEHVdqdLATYLDKCPKPG--LPPETIKDLMRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 301 KELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL--------TGEI------------PYKD--VDSS 358
Cdd:cd07838  155 RIYSFEMALTSVVVTLWYRAPEVLLQSSYATPVDMWSVGCIFAELFnrrplfrgSSEAdqlgkifdviglPSEEewPRNS 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755554055 359 AIIWGVGSNSLHLP----VPSTCPDGfKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd07838  235 ALPRSSFPSYTPRPfksfVPEIDEEG-LDLLKKMLTFNPHKRISAFEALQH 284
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
164-405 3.91e-24

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 103.27  E-value: 3.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEE--VAIKKVREQ-NETDIKHL--------RKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06617    3 LEVIEEL---GRGAYGVVDKMRHVPTGtiMAVKRIRATvNSQEQKRLlmdldismRSVDCPYTVTFYGALFREGDVWICM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EY--CAHGQLY-EVLRAGRKITPRLLVDWSTGIASGMNYLHLH-KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd06617   80 EVmdTSLDKFYkKVYDKGLTIPEDILGKIAVSIVKALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGISGYLVDSVA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSE----KVDIWSFGVVLWELLTGEIPYKDvdssaiiWG---------VGSNSLHLPVPS 375
Cdd:cd06617  160 KTIDAGCKPYMAPERINPELNQKgydvKSDVWSLGITMIELATGRFPYDS-------WKtpfqqlkqvVEEPSPQLPAEK 232
                        250       260       270
                 ....*....|....*....|....*....|
gi 755554055 376 TCPDgFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06617  233 FSPE-FQDFVNKCLKKNYKERPNYPELLQH 261
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
163-418 4.90e-24

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 104.91  E-value: 4.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFR--AEEVAIK--------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:PLN00034  72 SLSELERVNRIGSGAGGTVYKVIHRptGRLYALKviygnhedTVRRQICREIEILRDVNHPNVVKCHDMFDHNGEIQVLL 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLyevlrAGRKIT-PRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM- 310
Cdd:PLN00034 152 EFMDGGSL-----EGTHIAdEQFLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCn 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKV-----DIWSFGVVLWELLTGEIPY---KDVDSSAIIWGVGSNSLHLPVPSTCPDgFK 382
Cdd:PLN00034 227 SSVGTIAYMSPERINTDLNHGAYdgyagDIWSLGVSILEFYLGRFPFgvgRQGDWASLMCAICMSQPPEAPATASRE-FR 305
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 383 ILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQ 418
Cdd:PLN00034 306 HFISCCLQREPAKRWSAMQLLQHPFILRAQPGQGQG 341
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
164-357 6.60e-24

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 103.60  E-value: 6.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEEVAIKK----------VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06650    7 FEKISEL---GAGNGGVVFKVSHKPSGLVMARklihleikpaIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL-HLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSF 312
Cdd:cd06650   84 HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLrEKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSF 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS 357
Cdd:cd06650  163 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDA 207
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
166-398 9.31e-24

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 102.03  E-value: 9.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD-------IKHLRKL-KHPNII-----AFKGVCTQAPCYcI 230
Cdd:cd13985    1 RYQVTKQLGEGGFSYVYLAHDVNtgRRYALKRMYFNDEEQlrvaikeIEIMKRLcGHPNIVqyydsAILSSEGRKEVL-L 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAhGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFG-------- 298
Cdd:cd13985   80 LMEYCP-GSLVDILekSPPSPLSEEEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNTGRFKLCDFGsattehyp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 --TSKELSDKSTKMSFAGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGvgsnSLHLPV 373
Cdd:cd13985  159 leRAEEVNIIEEEIQKNTTPMYRAPEMIdlySKKPIGEKADIWALGCLLYKLCFFKLPFDESSKLAIVAG----KYSIPE 234
                        250       260
                 ....*....|....*....|....*
gi 755554055 374 PSTCPDGFKILMKQTWQSKPRNRPS 398
Cdd:cd13985  235 QPRYSPELHDLIRHMLTPDPAERPD 259
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
160-399 1.01e-23

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 103.52  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLG-------KFRAEEVAIKKVREqNETDIKH---LRKLK-------HPNIIAFKGVC 222
Cdd:cd05102    2 WEFPRDRLRLGKVLGHGAFGKVVEAsafgidkSSSCETVAVKMLKE-GATASEHkalMSELKilihignHLNVVNLLGAC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 T--QAPCYcIIMEYCAHGQLYEVLRAGRKI-------TPRL--------------------------------------- 254
Cdd:cd05102   81 TkpNGPLM-VIVEFCKYGNLSNFLRAKREGfspyrerSPRTrsqvrsmveavradrrsrqgsdrvasftestsstnqprq 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 --------------LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL---SDKSTKMSFAGTVA 317
Cdd:cd05102  160 evddlwqspltmedLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIykdPDYVRKGSARLPLK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNR 396
Cdd:cd05102  240 WMAPESIFDKVYTTQSDVWSFGVLLWEIFSlGASPYPGVQINEEFCQRLKDGTRMRAPEYATPEIYRIMLSCWHGDPKER 319

                 ...
gi 755554055 397 PSF 399
Cdd:cd05102  320 PTF 322
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
160-406 1.08e-23

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 103.54  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGK-FRAEE------VAIKKVRE---QNE-----TDIKHLRKL-KHPNIIAFKGVCT 223
Cdd:cd14207    2 WEFARERLKLGKSLGRGAFGKVVQASaFGIKKsptcrvVAVKMLKEgatASEykalmTELKILIHIgHHLNVVNLLGACT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 -QAPCYCIIMEYCAHGQLYEVLRAGRKI--------------------------TPRL---------------------- 254
Cdd:cd14207   82 kSGGPLMVIVEYCKYGNLSNYLKSKRDFfvtnkdtslqeelikekkeaeptggkKKRLesvtssesfassgfqedkslsd 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 --------------------LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL---SDKSTKMS 311
Cdd:cd14207  162 veeeeedsgdfykrpltmedLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIyknPDYVRKGD 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQ 390
Cdd:cd14207  242 ARLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSlGASPYPGVQIDEDFCSKLKEGIRMRAPEFATSEIYQIMLDCWQ 321
                        330
                 ....*....|....*.
gi 755554055 391 SKPRNRPSFRQTLMHL 406
Cdd:cd14207  322 GDPNERPRFSELVERL 337
PTKc_Kit cd05104
Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the ...
141-401 1.14e-23

Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270682 [Multi-domain]  Cd Length: 375  Bit Score: 104.22  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 141 WNIIGKAYSTDY------KLQQQDTWEVPFEEISELQWLGSGAQGAVF----LGKFRAEE---VAIKKV--------REQ 199
Cdd:cd05104    5 WKVVEEINGNNYvyidptQLPYDHKWEFPRDRLRFGKTLGAGAFGKVVeataYGLAKADSamtVAVKMLkpsahsteREA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 200 NETDIKHLRKL-KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK--ITPRL---------------------- 254
Cdd:cd05104   85 LMSELKVLSYLgNHINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDsfICPKFedlaeaalyrnllhqremacds 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 ---------------------------------------------------LVDWSTGIASGMNYLHLHKIIHRDLKSPN 283
Cdd:cd05104  165 lneymdmkpsvsyvvptkadkrrgvrsgsyvdqdvtseileedelaldtedLLSFSYQVAKGMEFLASKNCIHRDLAARN 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 284 VLVTHTDAVKISDFGTSKELSDKS---TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSA 359
Cdd:cd05104  245 ILLTHGRITKICDFGLARDIRNDSnyvVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWEIFSlGSSPYPGMPVDS 324
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 755554055 360 IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05104  325 KFYKMIKEGYRMDSPEFAPSEMYDIMRSCWDADPLKRPTFKQ 366
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
173-357 1.38e-23

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 102.21  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNE-----------TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14159    1 IGEGGFGCVYQAVMRNTEYAVKRLKEDSEldwsvvknsflTEVEKLSRFRHPNIVDLAGYSAQQGNYCLIYVYLPNGSLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLR---AGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGT---SKELSDKSTKMSFA 313
Cdd:cd14159   81 DRLHcqvSCPCLSWSQRLHVLLGTARAIQYLHSDSpsLIHGDVKSSNILLDAALNPKLGDFGLarfSRRPKQPGMSSTLA 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 ------GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKdVDS 357
Cdd:cd14159  161 rtqtvrGTLAYLPEEYVKTGTLSVEIDVYSFGVVLLELLTGRRAME-VDS 209
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
177-405 1.45e-23

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 101.05  E-value: 1.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 177 AQGAVFLGKFRAEEvAIKKVREQNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 256
Cdd:cd14111   26 ATGKNFPAKIVPYQ-AEEKQGVLQEYEI--LKSLHHERIMALHEAYITPRYLVLIAEFCSGKELLHSLIDRFRYSEDDVV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM--SFAGTVAWMAPEVIRNEPVSEKVD 334
Cdd:cd14111  103 GYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQSFNPLSLRQlgRRTGTLEYMAPEMVKGEPVGPPAD 182
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 335 IWSFGVVLWELLTGEIPYKDVD---SSAIIWGVGSNSLHL-PVPSTCPDGFkilMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14111  183 IWSIGVLTYIMLSGRSPFEDQDpqeTEAKILVAKFDAFKLyPNVSQSASLF---LKKVLSSYPWSRPTTKDCFAH 254
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
173-352 1.58e-23

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 101.99  E-value: 1.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIK--KVREQ-------NETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd06659   29 IGEGSTGVVCIAreKHSGRQVAVKmmDLRKQqrrellfNEVVI--MRDYQHPNVVEMYKSYLVGEELWVLMEYLQGGALT 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRkITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKSTKMSFAGTVAWMA 320
Cdd:cd06659  107 DIVSQTR-LNEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISkDVPKRKSLVGTPYWMA 185
                        170       180       190
                 ....*....|....*....|....*....|..
gi 755554055 321 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd06659  186 PEVISRCPYGTEVDIWSLGIMVIEMVDGEPPY 217
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
164-352 1.73e-23

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 101.22  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEIselqwlGSGAQGAVFLGKFRA--EEVAIKKV----REQNETDIKHLRKLKHPNIIAFKGvctqapCY------CII 231
Cdd:cd14010    5 YDEI------GRGKHSVVYKGRRKGtiEFVAIKCVdkskRPEVLNEVRLTHELKHPNVLKFYE------WYetsnhlWLV 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD------ 305
Cdd:cd14010   73 VEYCTGGDLETLLRQDGNLPESSVRKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLARREGEilkelf 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 306 -----------KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14010  153 gqfsdegnvnkVSKKQAKRGTPYYMAPELFQGGVHSFASDLWALGCVLYEMFTGKPPF 210
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
231-372 1.78e-23

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 102.38  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQL-YEVLRAGRKITPRLlVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKST 308
Cdd:cd05616   79 VMEYVNGGDLmYHIQQVGRFKEPHA-VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEnIWDGVT 157
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372
Cdd:cd05616  158 TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYP 221
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
173-356 1.79e-23

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 101.50  E-value: 1.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIK-----KVREQ-------NETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05580    9 LGTGSFGRVRLVKHKdsGKYYALKilkkaKIIKLkqvehvlNEKRI--LSEVRHPFIVNLLGSFQDDRNLYMVMEYVPGG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKStkMSFAGTVAW 318
Cdd:cd05580   87 ELFSLLRRSGRFPNDVAKFYAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRVKDRT--YTLCGTPEY 164
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05580  165 LAPEIILSKGHGKAVDWWALGILIYEMLAGYPPFFDEN 202
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
163-349 1.90e-23

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 102.06  E-value: 1.90e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGKFR--AEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCT--QAPCYC 229
Cdd:cd07845    5 SVTEFEKLNRIGEGTYGIVYRARDTtsGEIVALKKVRMDNERDgipisslreITLLLNLRHPNIVELKEVVVgkHLDSIF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAH--GQLYEVLRAG------RKITPRLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK 301
Cdd:cd07845   85 LVMEYCEQdlASLLDNMPTPfsesqvKCLMLQLL--------RGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLAR 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSDKSTKMSFAGTVAWM-APEVIRN-EPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd07845  157 TYGLPAKPMTPKVVTLWYrAPELLLGcTTYTTAIDMWAVGCILAELLAHK 206
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
171-347 1.99e-23

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 101.67  E-value: 1.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGKFRAEEVAIK------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPC-----YCIIMEYCAHGQ 239
Cdd:cd14054    1 QLIGQGRYGTVWKGSLDERPVAVKvfparhRQNFQNEKDIYELPLMEHSNILRFIGADERPTAdgrmeYLLVLEYAPKGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRkitprllVDWST------GIASGMNYLH-------LHK--IIHRDLKSPNVLVTHTDAVKISDFGTSKELS 304
Cdd:cd14054   81 LCSYLRENT-------LDWMSscrmalSLTRGLAYLHtdlrrgdQYKpaIAHRDLNSRNVLVKADGSCVICDFGLAMVLR 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 305 DKS-----------TKMSFAGTVAWMAPEV------IRNEPVSEK-VDIWSFGVVLWELLT 347
Cdd:cd14054  154 GSSlvrgrpgaaenASISEVGTLRYMAPEVlegavnLRDCESALKqVDVYALGLVLWEIAM 214
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
255-406 2.36e-23

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 103.55  E-value: 2.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEPVSE 331
Cdd:cd05107  241 LVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTflpLKWMAPESIFNNLYTT 320
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 332 KVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQtLMHL 406
Cdd:cd05107  321 LSDVWSFGILLWEIFTlGGTPYPELPMNEQFYNAIKRGYRMAKPAHASDEIYEIMQKCWEEKFEIRPDFSQ-LVHL 395
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
173-352 2.41e-23

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 100.38  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVF------LGKFRAEEVaIKKVREQNETDIKH----LRKLKHPNII----AFKgvcTQAPCyCIIMEYCAHG 238
Cdd:cd14103    1 LGRGKFGTVYrcvekaTGKELAAKF-IKCRKAKDREDVRNeieiMNQLRHPRLLqlydAFE---TPREM-VLVMEYVAGG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYE-VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKEL-SDKSTKMSFaG 314
Cdd:cd14103   76 ELFErVVDDDFELTERDCILFMRQICEGVQYMHKQGILHLDLKPENILCVSRTGnqIKIIDFGLARKYdPDKKLKVLF-G 154
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14103  155 TPEFVAPEVVNYEPISYATDMWSVGVICYVLLSGLSPF 192
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
231-356 3.05e-23

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 101.70  E-value: 3.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQL-YEVLRAGRKITPrLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE--LSDKS 307
Cdd:cd05587   75 VMEYVNGGDLmYHIQQVGKFKEP-VAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEgiFGGKT 153
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755554055 308 TKmSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05587  154 TR-TFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 201
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
143-372 3.93e-23

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 100.47  E-value: 3.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 143 IIGKAYSTDYKLQQQDTWEVpfeeiseLQWLGSGAQGAVF--LGKFRAEEVAIK------KVREQNETDIKHLRKLK-HP 213
Cdd:cd06638    3 LSGKTIIFDSFPDPSDTWEI-------IETIGKGTYGKVFkvLNKKNGSKAAVKildpihDIDEEIEAEYNILKALSdHP 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 214 NIIAFKGV-----CTQAPCYCIIMEYCAHGQLYEV----LRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNV 284
Cdd:cd06638   76 NVVKFYGMyykkdVKNGDQLWLVLELCNGGSVTDLvkgfLKRGERMEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 285 LVTHTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNE-----PVSEKVDIWSFGVVLWELLTGEIPYKDVDSS 358
Cdd:cd06638  156 LLTTEGGVKLVDFGVSAQLtSTRLRRNTSVGTPFWMAPEVIACEqqldsTYDARCDVWSLGITAIELGDGDPPLADLHPM 235
                        250
                 ....*....|....*..
gi 755554055 359 AIIWGVGSN---SLHLP 372
Cdd:cd06638  236 RALFKIPRNpppTLHQP 252
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
163-405 4.35e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 100.12  E-value: 4.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGK--FRAEEVAIKKVREQNETD-------IKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06645    9 PQEDFELIQRIGSGTYGDVYKARnvNTGELAAIKVIKLEPGEDfavvqqeIIMMKDCKHSNIVAYFGSYLRRDKLWICME 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK-STKMSF 312
Cdd:cd06645   89 FCGGGSLQDIYHVTGPLSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATiAKRKSF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV---PSTCPDGFKILMK 386
Cdd:cd06645  169 IGTPYWMAPEVAaveRKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKlkdKMKWSNSFHHFVK 248
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd06645  249 MALTKNPKKRPTAEKLLQH 267
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
173-353 4.88e-23

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 101.16  E-value: 4.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL------GKFRAEEVAIKKV--------REQNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05574    9 LGKGDVGRVYLvrlkgtGKLFAMKVLDKEEmikrnkvkRVLTEREI--LATLDHPFLPTLYASFQTSTHLCFVMDYCPGG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRagRKITPRLLVDWSTGIAS----GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM---- 310
Cdd:cd05574   87 ELFRLLQ--KQPGKRLPEEVARFYAAevllALEYLHLLGFVYRDLKPENILLHESGHIMLTDFDLSKQSSVTPPPVrksl 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 311 --------------------------SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd05574  165 rkgsrrssvksieketfvaepsarsnSFVGTEEYIAPEVIKGDGHGSAVDWWTLGILLYEMLYGTTPFK 233
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
166-346 5.14e-23

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 99.95  E-value: 5.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRAE--EVAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAP--------- 226
Cdd:cd14048    7 DFEPIQCLGRGGFGVVFEAKNKVDdcNYAVKRIRLPNNElarekvlrEVRALAKLDHPGIVRYFNAWLERPpegwqekmd 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 -CYC-IIMEYCAHGQLYEVLRAGRKITPR---LLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG--- 298
Cdd:cd14048   87 eVYLyIQMQLCRKENLKDWMNRRCTMESRelfVCLNIFKQIASAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVGDFGlvt 166
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 ------------TSKELSDKSTKMsfAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 346
Cdd:cd14048  167 amdqgepeqtvlTPMPAYAKHTGQ--VGTRLYMSPEQIHGNQYSEKVDIFALGLILFELI 224
PTKc_CSF-1R cd05106
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs ...
141-401 5.93e-23

Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. CSF-1R, also called c-Fms, is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of CSF-1R to its ligand, CSF-1, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. It leads to increases in gene transcription and protein translation, and induces cytoskeletal remodeling. CSF-1R signaling leads to a variety of cellular responses including survival, proliferation, and differentiation of target cells. It plays an important role in innate immunity, tissue development and function, and the pathogenesis of some diseases including atherosclerosis and cancer. CSF-1R signaling is also implicated in mammary gland development during pregnancy and lactation. Aberrant CSF-1/CSF-1R expression correlates with tumor cell invasiveness, poor clinical prognosis, and bone metastasis in breast cancer. Although the structure of the human CSF-1R catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. The CSF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133237 [Multi-domain]  Cd Length: 374  Bit Score: 101.85  E-value: 5.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 141 WNIIGKAYSTDY------KLQQQDTWEVPFEEISELQWLGSGAQGAVF------LGKF-RAEEVAIKKVREQNETD---- 203
Cdd:cd05106    8 WKIIEAAEGNNYtfidptQLPYNEKWEFPRDNLQFGKTLGAGAFGKVVeatafgLGKEdNVLRVAVKMLKASAHTDerea 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 204 ----IKHLRKL-KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR--------------------------------- 245
Cdd:cd05106   88 lmseLKILSHLgQHKNIVNLLGACTHGGPVLVITEYCCYGDLLNFLRkkaetflnfvmalpeisetssdyknitlekkyi 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 ---------------AGRKITPRL----------------------LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH 288
Cdd:cd05106  168 rsdsgfssqgsdtyvEMRPVSSSSsqssdskdeedtedswpldlddLLRFSSQVAQGMDFLASKNCIHRDVAARNVLLTD 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 289 TDAVKISDFGTSKELSDKS---TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGV 364
Cdd:cd05106  248 GRVAKICDFGLARDIMNDSnyvVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSlGKSPYPGILVNSKFYKM 327
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 755554055 365 GSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd05106  328 VKRGYQMSRPDFAPPEIYSIMKMCWNLEPTERPTFSQ 364
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
173-353 6.42e-23

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 99.27  E-value: 6.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKV----------REQNETDIKHLRKLKHPNIIafkgvctqapCYC----------I 230
Cdd:cd08224    8 IGKGQFSVVYRARCLLDGrlVALKKVqifemmdakaRQDCLKEIDLLQQLNHPNII----------KYLasfiennelnI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLR----AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd08224   78 VLELADAGDLSRLIKhfkkQKRLIPERTIWKYFVQLCSALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLGRFFSSK 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 307 STKM-SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd08224  158 TTAAhSLVGTPYYMSPERIREQGYDFKSDIWSLGCLLYEMAALQSPFY 205
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
164-352 9.67e-23

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 98.94  E-value: 9.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQ-GAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14194   18 FAVVKKCREKSTGLQyAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA----VKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14194   98 FLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVpkprIKIIDFGLAHKIDFGNEFKNIFGTPEF 177
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14194  178 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPF 211
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
180-405 1.11e-22

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 98.71  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 180 AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWS 259
Cdd:cd14105   35 AKFIKKRRSKASRRGVSREDIEREVSILRQVLHPNIITLHDVFENKTDVVLILELVAGGELFDFLAEKESLSEEEATEFL 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA----VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 335
Cdd:cd14105  115 KQILDGVNYLHTKNIAHFDLKPENIMLLDKNVpiprIKLIDFGLAHKIEDGNEFKNIFGTPEFVAPEIVNYEPLGLEADM 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554055 336 WSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL--PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14105  195 WSIGVITYILLSGASPFLGDTKQETLANITAVNYDFddEYFSNTSELAKDFIRQLLVKDPRKRMTIQESLRH 266
PTK_Jak_rpt1 cd05037
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak ...
167-406 1.26e-22

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. In the case of Jak2, the presumed pseudokinase (repeat 1) domain exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270633 [Multi-domain]  Cd Length: 259  Bit Score: 98.32  E-value: 1.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVFLGKFR------AEEVAI-KKVREQNETDI--------KHLRKLKHPNIIAFKGVCTqAPCYCII 231
Cdd:cd05037    1 ITFHEHLGQGTFTNIYDGILRevgdgrVQEVEVlLKVLDSDHRDIsesffetaSLMSQISHKHLVKLYGVCV-ADENIMV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLR-AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA------VKISDFGTSKELS 304
Cdd:cd05037   80 QEYVRYGPLDKYLRrMGNNVPLSWKLQVAKQLASALHYLEDKKLIHGNVRGRNILLAREGLdgyppfIKLSDPGVPITVL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 305 DKSTKMSfagTVAWMAPEVIRNEP--VSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLhLPVPStCPDGF 381
Cdd:cd05037  160 SREERVD---RIPWIAPECLRNLQanLTIAADKWSFGTTLWEICSgGEEPLSALSSQEKLQFYEDQHQ-LPAPD-CAELA 234
                        250       260
                 ....*....|....*....|....*
gi 755554055 382 KiLMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05037  235 E-LIMQCWTYEPTKRPSFRAILRDL 258
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
199-405 1.35e-22

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 98.17  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 199 QNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD 278
Cdd:cd14095   46 ENEVAI--LRRVKHPNIVQLIEEYDTDTELYLVMELVKGGDLFDAITSSTKFTERDASRMVTDLAQALKYLHSLSIVHRD 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 279 LKSPNVLV----THTDAVKISDFGTSKELsdKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14095  124 IKPENLLVveheDGSKSLKLADFGLATEV--KEPLFTVCGTPTYVAPEILAETGYGLKVDIWAAGVITYILLCGFPPFRS 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 355 VDSS------AIIWGvgsnSLHLPVPS--TCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14095  202 PDRDqeelfdLILAG----EFEFLSPYwdNISDSAKDLISRMLVVDPEKRYSAGQVLDH 256
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
200-352 1.49e-22

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 98.58  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 200 NETDIkhLRKL-KHPNIIAFKGVcTQAPCYC-IIMEYCAHGQLY----EVLRAGRKITPRLLVDwstgIASGMNYLHLHK 273
Cdd:cd14093   57 REIEI--LRQVsGHPNIIELHDV-FESPTFIfLVFELCRKGELFdyltEVVTLSEKKTRRIMRQ----LFEAVEFLHSLN 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 274 IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR-----NEP-VSEKVDIWSFGVVLWELLT 347
Cdd:cd14093  130 IVHRDLKPENILLDDNLNVKISDFGFATRLDEGEKLRELCGTPGYLAPEVLKcsmydNAPgYGKEVDMWACGVIMYTLLA 209

                 ....*
gi 755554055 348 GEIPY 352
Cdd:cd14093  210 GCPPF 214
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
173-396 1.56e-22

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 99.70  E-value: 1.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV--AIK-----KVREQNETdiKH--------LRKLKHPNIIA----FKgvcTQAPCYcIIME 233
Cdd:cd05575    3 IGKGSFGKVLLARHKAEGKlyAVKvlqkkAILKRNEV--KHimaernvlLKNVKHPFLVGlhysFQ---TKDKLY-FVLD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSF 312
Cdd:cd05575   77 YVNGGELFFHLQRERHFPEPRARFYAAEIASALGYLHSLNIIYRDLKPENILLDSQGHVVLTDFGLCKEgIEPSDTTSTF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSTCPDgfkiLMKQTWQ 390
Cdd:cd05575  157 CGTPEYLAPEVLRKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRDTAEMYDNILHKPLRLRtnVSPSARD----LLEGLLQ 232

                 ....*.
gi 755554055 391 SKPRNR 396
Cdd:cd05575  233 KDRTKR 238
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
195-405 1.99e-22

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 97.65  E-value: 1.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 195 KVREQNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKI 274
Cdd:cd14107   42 RARAFQERDI--LARLSHRRLTCLLDQFETRKTLILILELCSSEELLDRLFLKGVVTEAEVKLYIQQVLEGIGYLHGMNI 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 275 IHRDLKSPNVLVTHT--DAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14107  120 LHLDIKPDNILMVSPtrEDIKICDFGFAQEITPSEHQFSKYGSPEFVAPEIVHQEPVSAATDIWALGVIAYLSLTCHSPF 199
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 353 KDVDSSAIIWGV--GSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14107  200 AGENDRATLLNVaeGVVSWDTPEITHLSEDAKDFIKRVLQPDPEKRPSASECLSH 254
PHA02988 PHA02988
hypothetical protein; Provisional
175-378 2.20e-22

hypothetical protein; Provisional


Pssm-ID: 165291 [Multi-domain]  Cd Length: 283  Bit Score: 98.28  E-value: 2.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 175 SGAQGAVFLGKFRAEEVAI----------KKVREQNETDIKHLRKLKHPNIIAFKG----VCTQAPCYCIIMEYCAHGQL 240
Cdd:PHA02988  30 ENDQNSIYKGIFNNKEVIIrtfkkfhkghKVLIDITENEIKNLRRIDSNNILKIYGfiidIVDDLPRLSLILEYCTRGYL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLH-KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMsfAGTVAWM 319
Cdd:PHA02988 110 REVLDKEKDLSFKTKLDMAIDCCKGLYNLYKYtNKPYKNLTSVSFLVTENYKLKIICHGLEKILSSPPFKN--VNFMVYF 187
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 320 APEVIRN--EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCP 378
Cdd:PHA02988 188 SYKMLNDifSEYTIKDDIYSLGVVLWEIFTGKIPFENLTTKEIYDLIINKNNSLKLPLDCP 248
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
173-352 2.45e-22

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 97.46  E-value: 2.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVrEQNETDIKHLRK----------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14071    8 IGKGNFAVVKLARHRitKTEVAIKII-DKSQLDEENLKKiyrevqimkmLNHPHIIKLYQVMETKDMLYLVTEYASNGEI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMA 320
Cdd:cd14071   87 FDYLAQHGRMSEKEARKKFWQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPGELLKTWCGSPPYAA 166
                        170       180       190
                 ....*....|....*....|....*....|...
gi 755554055 321 PEVIR-NEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14071  167 PEVFEgKEYEGPQLDIWSLGVVLYVLVCGALPF 199
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
230-439 2.59e-22

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 101.63  E-value: 2.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRagRKITPRL-LVDWSTG-----IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 303
Cdd:PTZ00267 142 LIMEYGSGGDLNKQIK--QRLKEHLpFQEYEVGllfyqIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGFSKQY 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 SDKST---KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSlHLPVPSTCPDG 380
Cdd:PTZ00267 220 SDSVSldvASSFCGTPYYLAPELWERKRYSKKADMWSLGVILYELLTLHRPFKGPSQREIMQQVLYGK-YDPFPCPVSSG 298
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 381 FKILMKQTWQSKPRNRPSFRQTLmhldiasadvlatpQETYFKSQAEWREEVKKHFEKI 439
Cdd:PTZ00267 299 MKALLDPLLSKNPALRPTTQQLL--------------HTEFLKYVANLFQDIVRHSETI 343
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
173-405 3.00e-22

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 97.63  E-value: 3.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKV-REQNETD-IKH-LRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14117   14 LGKGKFGNVYLAREKQSKfiVALKVLfKSQIEKEgVEHqLRReieiqshLRHPNILRLYNYFHDRKRIYLILEYAPRGEL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKmSFAGTVAWMA 320
Cdd:cd14117   94 YKELQKHGRFDEQRTATFMEELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRR-TMCGTLDYLP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 321 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVgsNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd14117  173 PEMIEGRTHDEKVDLWCIGVLCYELLVGMPPFESASHTETYRRI--VKVDLKFPPFLSDGSRDLISKLLRYHPSERLPLK 250

                 ....*
gi 755554055 401 QTLMH 405
Cdd:cd14117  251 GVMEH 255
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
173-350 3.00e-22

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 98.75  E-value: 3.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVR--EQNETD-------IKHLRKLKHPNIIA------------FKGVctqapcYc 229
Cdd:cd07834    8 IGSGAYGVVCSAydKRTGRKVAIKKISnvFDDLIDakrilreIKILRHLKHENIIGlldilrppspeeFNDV------Y- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYcAHGQLYEVLRAGRKITP--------RLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK 301
Cdd:cd07834   81 IVTEL-METDLHKVIKSPQPLTDdhiqyflyQIL--------RGLKYLHSAGVIHRDLKPSNILVNSNCDLKICDFGLAR 151
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755554055 302 ELSDKSTKMSFAGTVA--WM-APEVIRNEP-VSEKVDIWSFGVVLWELLTGEI 350
Cdd:cd07834  152 GVDPDEDKGFLTEYVVtrWYrAPELLLSSKkYTKAIDIWSVGCIFAELLTRKP 204
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
173-373 3.11e-22

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 98.61  E-value: 3.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV-----AIKK--VREQNETDIKHLRK------LKHPNIIAFkgVCT-QAPCYC-IIMEYCAH 237
Cdd:cd05592    3 LGKGSFGKVMLAELKGTNQyfaikALKKdvVLEDDDVECTMIERrvlalaSQHPFLTHL--FCTfQTESHLfFVMEYLNG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQL-YEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGT 315
Cdd:cd05592   81 GDLmFHIQQSGRFDEDRARF-YGAEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKEnIYGENKASTFCGT 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 373
Cdd:cd05592  160 PDYIAPEILKGQKYNQSVDWWSFGVLLYEMLIGQSPFHGEDEDELFWSICNDTPHYPR 217
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
170-354 3.41e-22

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 97.55  E-value: 3.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAE-------EVAIKKVREQN----------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd14076    6 GRTLGEGEFGKVKLGWPLPKanhrsgvQVAIKLIRRDTqqencqtskiMREINILKGLTHPNIVRLLDVLKTKKYIGIVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKSTKMS 311
Cdd:cd14076   86 EFVSGGELFDYILARRRLKDSVACRLFAQLISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFANTFDhFNGDLMS 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 312 FA-GTVAWMAPEVIRNEPVSE--KVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14076  166 TScGSPCYAAPELVVSDSMYAgrKADIWSCGVILYAMLAGYLPFDD 211
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
160-414 3.55e-22

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 98.20  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISEL----QWLGSGAQGAVFL------GKFRAEEVAIKKVREQNETDIKH----LRKLKHPNIIAFKGVCTQA 225
Cdd:cd14168    1 WKKQVEDIKKIfefkEVLGTGAFSEVVLaeeratGKLFAVKCIPKKALKGKESSIENeiavLRKIKHENIVALEDIYESP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKe 302
Cdd:cd14168   81 NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYFSQDeesKIMISDFGLSK- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 303 LSDKSTKMSFA-GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP--STCPD 379
Cdd:cd14168  160 MEGKGDVMSTAcGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKADYEFDSPywDDISD 239
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVL 414
Cdd:cd14168  240 SAKDFIRNLMEKDPNKRYTCEQALRHPWIAGDTAL 274
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
255-400 3.80e-22

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 100.10  E-value: 3.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEPVSE 331
Cdd:cd05105  239 LLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTflpVKWMAPESIFDNLYTT 318
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 332 KVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05105  319 LSDVWSYGILLWEIFSlGGTPYPGMIVDSTFYNKIKSGYRMAKPDHATQEVYDIMVKCWNSEPEKRPSFL 388
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
170-352 4.56e-22

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 98.25  E-value: 4.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL---------GKFRAEEVAIKKVREQNETDIKH-------LRKLKHPNII----AFKgvcTQAPCYc 229
Cdd:cd05584    1 LKVLGKGGYGKVFQvrkttgsdkGKIFAMKVLKKASIVRNQKDTAHtkaerniLEAVKHPFIVdlhyAFQ---TGGKLY- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVL-RAGrkITPRLLVDWSTG-IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDK 306
Cdd:cd05584   77 LILEYLSGGELFMHLeREG--IFMEDTACFYLAeITLALGHLHSLGIIYRDLKPENILLDAQGHVKLTDFGLCKEsIHDG 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 307 STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05584  155 TVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGAPPF 200
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
173-353 4.82e-22

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 97.95  E-value: 4.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIK--------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCY--CIIMEYCAHGQL 240
Cdd:cd13988    1 LGQGATANVFRGrhKKTGDLYAVKvfnnlsfmRPLDVQMREFEVLKKLNHKNIVKLFAIEEELTTRhkVLVMELCPCGSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRA-----GRKITPRLLVdwSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD----AVKISDFGTSKELSDKSTKMS 311
Cdd:cd13988   81 YTVLEEpsnayGLPESEFLIV--LRDVVAGMNHLRENGIVHRDIKPGNIMRVIGEdgqsVYKLTDFGAARELEDDEQFVS 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPE-----VIRNE---PVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd13988  159 LYGTEEYLHPDmyeraVLRKDhqkKYGATVDLWSIGVTFYHAATGSLPFR 208
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
165-354 6.71e-22

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 97.12  E-value: 6.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLG---KFRAEEVAIKKVREQ----------------NETDIkhLRKLKHPNIIAFKGVCTQA 225
Cdd:cd14096    1 ENYRLINKIGEGAFSNVYKAvplRNTGKPVAIKVVRKAdlssdnlkgssranilKEVQI--MKRLSHPNIVKLLDFQESD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL----------VTHTDA---- 291
Cdd:cd14096   79 EYYYIVLELADGGEIFHQIVRLTYFSEDLSRHVITQVASAVKYLHEIGVVHRDIKPENLLfepipfipsiVKLRKAddde 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 292 -------------------VKISDFGTSKELSDKSTKMSfAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14096  159 tkvdegefipgvggggigiVKLADFGLSKQVWDSNTKTP-CGTVGYTAPEVVKDERYSKKVDMWALGCVLYTLLCGFPPF 237

                 ..
gi 755554055 353 KD 354
Cdd:cd14096  238 YD 239
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
191-405 6.77e-22

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 96.15  E-value: 6.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 191 VAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLH 270
Cdd:cd14189   39 VAKPHQREKIVNEIELHRDLHHKHVVKFSHHFEDAENIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLKQIISGLKYLH 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 271 LHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd14189  119 LKGILHRDLKLGNFFINENMELKVGDFGLAARLePPEQRKKTICGTPNYLAPEVLLRQGHGPESDVWSLGCVMYTLLCGN 198
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 350 IPYKDVDSSAIIWGVgsNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14189  199 PPFETLDLKETYRCI--KQVKYTLPASLSLPARHLLAGILKRNPGDRLTLDQILEH 252
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
161-356 7.05e-22

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 98.56  E-value: 7.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 161 EVPFEEISELQWLGSGAQGAVFLGKFRA------------EEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd05594   21 KVTMNDFEYLKLLGKGTFGKVILVKEKAtgryyamkilkkEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK-IIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDK 306
Cdd:cd05594  101 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKnVVYRDLKLENLMLDKDGHIKITDFGLCKEgIKDG 180
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05594  181 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 230
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
181-403 7.40e-22

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 96.16  E-value: 7.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 181 VFLGKFRAEEVAIK-KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWS 259
Cdd:cd14187   34 VFAGKIVPKSLLLKpHQKEKMSMEIAIHRSLAHQHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKALTEPEARYYL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 338
Cdd:cd14187  114 RQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKVEyDGERKKTLCGTPNYIAPEVLSKKGHSFEVDIWSI 193
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 339 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL-----PVPSTcpdgfkiLMKQTWQSKPRNRPSFRQTL 403
Cdd:cd14187  194 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIpkhinPVAAS-------LIQKMLQTDPTARPTINELL 256
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
158-347 7.55e-22

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 97.44  E-value: 7.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 158 DTWEVPF-EEISE---LQWLGSGAQGAVFLGKFR--AEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVC 222
Cdd:cd07865    1 DQVEFPFcDEVSKyekLAKIGQGTFGEVFKARHRktGQIVALKKVLMENEKegfpitalrEIKILQLLKHENVVNLIEIC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 -TQA-------PCYCIIMEYCAH---GQLYEV-----LRAGRKITPRLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd07865   81 rTKAtpynrykGSIYLVFEFCEHdlaGLLSNKnvkftLSEIKKVMKMLL--------NGLYYIHRNKILHRDMKAANILI 152
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 287 THTDAVKISDFGTSKELS----DKSTKMSFAGTVAWM-APEVIRNE-PVSEKVDIWSFGVVLWELLT 347
Cdd:cd07865  153 TKDGVLKLADFGLARAFSlaknSQPNRYTNRVVTLWYrPPELLLGErDYGPPIDMWGAGCIMAEMWT 219
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
170-352 7.65e-22

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 96.05  E-value: 7.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGK--FRAEEVAIKKV--REQNETDIKHL-------RKLKHPNIIA-FKGVCTQAPCYcIIMEYCAH 237
Cdd:cd14072    5 LKTIGKGNFAKVKLARhvLTGREVAIKIIdkTQLNPSSLQKLfrevrimKILNHPNIVKlFEVIETEKTLY-LVMEYASG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA 317
Cdd:cd14072   84 GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTPGNKLDTFCGSPP 163
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 318 WMAPEVIRNEPVS-EKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14072  164 YAAPELFQGKKYDgPEVDVWSLGVILYTLVSGSLPF 199
PTKc_Aatyk1 cd05087
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs ...
170-398 8.12e-22

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk1 (or simply Aatyk) is also called lemur tyrosine kinase 1 (Lmtk1). It is a cytoplasmic (or nonreceptor) kinase containing a long C-terminal region. The expression of Aatyk1 is upregulated during growth arrest and apoptosis in myeloid cells. Aatyk1 has been implicated in neural differentiation, and is a regulator of the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation and survival, epithelial transport, and blood pressure control. The Aatyk1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270670 [Multi-domain]  Cd Length: 271  Bit Score: 96.21  E-value: 8.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRA----EEVAIKK------VREQNE--TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd05087    2 LKEIGHGWFGKVFLGEVNSglssTQVVVKElkasasVQDQMQflEEAQPYRALQHTNLLQCLAQCAEVTPYLLVMEFCPL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKIT-----PRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGtskeLSDKSTKMSF 312
Cdd:cd05087   82 GDLKGYLRSCRAAEsmapdPLTLQRMACEVACGLLHLHRNNFVHSDLALRNCLLTADLTVKIGDYG----LSHCKYKEDY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGT-------VAWMAPEVIR----NEPVSEKV---DIWSFGVVLWELLT-GEIPYKDV-DSSAIIWGVGSNSLHLPVPS- 375
Cdd:cd05087  158 FVTadqlwvpLRWIAPELVDevhgNLLVVDQTkqsNVWSLGVTIWELFElGNQPYRHYsDRQVLTYTVREQQLKLPKPQl 237
                        250       260
                 ....*....|....*....|....*
gi 755554055 376 --TCPDGFKILMKQTWQsKPRNRPS 398
Cdd:cd05087  238 klSLAERWYEVMQFCWL-QPEQRPT 261
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
170-346 9.06e-22

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 98.02  E-value: 9.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAE-EVAIKKVREQNETDIKH--LRKLKHPNIIAFKGVCTQAPCYCIIMEYcAHGQLYEVL-R 245
Cdd:PHA03209  71 IKTLTPGSEGRVFVATKPGQpDPVVLKIGQKGTTLIEAmlLQNVNHPSVIRMKDTLVSGAITCMVLPH-YSSDLYTYLtK 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR 325
Cdd:PHA03209 150 RSRPLPIDQALIIEKQILEGLRYLHAQRIIHRDVKTENIFINDVDQVCIGDLGAAQFPVVAPAFLGLAGTVETNAPEVLA 229
                        170       180
                 ....*....|....*....|.
gi 755554055 326 NEPVSEKVDIWSFGVVLWELL 346
Cdd:PHA03209 230 RDKYNSKADIWSAGIVLFEML 250
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
176-396 1.09e-21

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 96.32  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLGKFRA--EEVAIKKVREQN------------ETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd05609   11 GAYGAVYLVRHREtrQRFAMKKINKQNlilrnqiqqvfvERDI--LTFAENPFVVSMYCSFETKRHLCMVMEYVEGGDCA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRagrKITPrLLVDWSTGIAS----GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK---------------- 301
Cdd:cd05609   89 TLLK---NIGP-LPVDMARMYFAetvlALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGLSKiglmslttnlyeghie 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ----ELSDKSTkmsfAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP---------YKDVDSSAIIWGVGSNS 368
Cdd:cd05609  165 kdtrEFLDKQV----CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPffgdtpeelFGQVISDEIEWPEGDDA 240
                        250       260
                 ....*....|....*....|....*...
gi 755554055 369 LhlpvpstcPDGFKILMKQTWQSKPRNR 396
Cdd:cd05609  241 L--------PDDAQDLITRLLQQNPLER 260
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
164-352 1.15e-21

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 95.79  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISElqWLGSG-----------AQGAVFLGKF---RAEEVAIKKV-REQNETDIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd14196    6 FYDIGE--ELGSGqfaivkkcrekSTGLEYAAKFikkRQSRASRRGVsREEIEREVSILRQVLHPNIITLHDVYENRTDV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA----VKISDFGTSKELS 304
Cdd:cd14196   84 VLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIpiphIKLIDFGLAHEIE 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 305 DKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14196  164 DGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPF 211
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
173-354 1.24e-21

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 96.43  E-value: 1.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNE-----TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR 245
Cdd:cd14085   11 LGRGATSVVYRCRQKGtqKPYAVKKLKKTVDkkivrTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT--DA-VKISDFGTSKELSDKSTKMSFAGTVAWMAPE 322
Cdd:cd14085   91 EKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPapDApLKIADFGLSKIVDQQVTMKTVCGTPGYCAPE 170
                        170       180       190
                 ....*....|....*....|....*....|..
gi 755554055 323 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14085  171 ILRGCAYGPEVDMWSVGVITYILLCGFEPFYD 202
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
170-352 1.27e-21

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 97.39  E-value: 1.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAEEV--AIKKVREQ---NETDIKH--------LRKLKHPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd05602   12 LKVIGKGSFGKVLLARHKSDEKfyAVKVLQKKailKKKEEKHimsernvlLKNVKHPFLVGLHFSFQTTDKLYFVLDYIN 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRK-ITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAG 314
Cdd:cd05602   92 GGELFYHLQRERCfLEPRARF-YAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKEnIEPNGTTSTFCG 170
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05602  171 TPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF 208
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
160-405 1.42e-21

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 96.29  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKFRAEEV--AIKK-VREQNETDIKH-LRKLK-----H--PNIIAFKG-------- 220
Cdd:cd06618   10 YKADLNDLENLGEIGSGTCGQVYKMRHKKTGHvmAVKQmRRSGNKEENKRiLMDLDvvlksHdcPYIVKCYGyfitdsdv 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 221 -VCTQapcyciIMEYCAHGQLyevLRAGRKITPRLLVDWSTGIASGMNYLHL-HKIIHRDLKSPNVLVTHTDAVKISDFG 298
Cdd:cd06618   90 fICME------LMSTCLDKLL---KRIQGPIPEDILGKMTVSIVKALHYLKEkHGVIHRDVKPSNILLDESGNVKLCDFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 TSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE---KVDIWSFGVVLWELLTGEIPYKDVDSSaiiWGVGSNSLHLPVPS 375
Cdd:cd06618  161 ISGRLVDSKAKTRSAGCAAYMAPERIDPPDNPKydiRADVWSLGISLVELATGQFPYRNCKTE---FEVLTKILNEEPPS 237
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 376 TCPDG-----FKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06618  238 LPPNEgfspdFCSFVDLCLTKDHRYRPKYRELLQH 272
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
170-352 1.55e-21

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 96.91  E-value: 1.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL---------GKFRAEEVAIKKVREQNETDIKHLRK----LKH----PNII----AFKgvcTQAPCY 228
Cdd:cd05614    5 LKVLGTGAYGKVFLvrkvsghdaNKLYAMKVLRKAALVQKAKTVEHTRTernvLEHvrqsPFLVtlhyAFQ---TDAKLH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 cIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL--SDK 306
Cdd:cd05614   82 -LILDYVSGGELFTHLYQRDHFSEDEVRFYSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSKEFltEEK 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 307 STKMSFAGTVAWMAPEVIRNEPVSEK-VDIWSFGVVLWELLTGEIPY 352
Cdd:cd05614  161 ERTYSFCGTIEYMAPEIIRGKSGHGKaVDWWSLGILMFELLTGASPF 207
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
170-399 2.04e-21

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 97.76  E-value: 2.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVF--LGKFRAEEVAIKK-VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM-EYcaHGQLYEVLR 245
Cdd:PHA03212  97 LETFTPGAEGFAFacIDNKTCEHVVIKAgQRGGTATEAHILRAINHPSIIQLKGTFTYNKFTCLILpRY--KTDLYCYLA 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD--KSTKMSFAGTVAWMAPEV 323
Cdd:PHA03212 175 AKRNIAICDILAIERSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAACFPVDinANKYYGWAGTIATNAPEL 254
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 324 IRNEPVSEKVDIWSFGVVLWELLTGEIPY-------KDVDSSA----IIWGVGSNSLHLPV-PSTCPDGFKILMKQTWQS 391
Cdd:PHA03212 255 LARDPYGPAVDIWSAGIVLFEMATCHDSLfekdgldGDCDSDRqiklIIRRSGTHPNEFPIdAQANLDEIYIGLAKKSSR 334

                 ....*...
gi 755554055 392 KPRNRPSF 399
Cdd:PHA03212 335 KPGSRPLW 342
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
170-356 2.10e-21

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 94.76  E-value: 2.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAE--EVAIK---KVREQNETDIKH---------------LRKLKHPNIIAFKGVCTQAPCYC 229
Cdd:cd14004    5 LKEMGEGAYGQVNLAIYKSKgkEVVIKfifKERILVDTWVRDrklgtvpleihildtLNKRSHPNIVKLLDFFEDDEFYY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEycAHGQ---LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsdK 306
Cdd:cd14004   85 LVME--KHGSgmdLFDFIERKPNMDEKEAKYIFRQVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDFGSAAYI--K 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755554055 307 STKMS-FAGTVAWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd14004  161 SGPFDtFVGTIDYAAPEVLRGNPyGGKEQDIWALGVLLYTLVFKENPFYNIE 212
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
176-352 2.13e-21

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 94.85  E-value: 2.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLGKFRA--EEVAIKKVREQNE------TDIKHLRKLKH-----PNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd05611    7 GAFGSVYLAKKRStgDYFAIKVLKKSDMiaknqvTNVKAERAIMMiqgesPYVAKLYYSFQSKDYLYLVMEYLNGGDCAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLragrKITPRLLVDWS----TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd05611   87 LI----KTLGGLPEDWAkqyiAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGLSRNGLEKRHNKKFVGTPDY 162
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05611  163 LAPETILGVGDDKMSDWWSLGCVIFEFLFGYPPF 196
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
173-352 2.13e-21

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 95.15  E-value: 2.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL---------GKFRAEEVAIK-------KVREQNETDIKHLRKLKH-PNII----AFKgvcTQAPCYcII 231
Cdd:cd05583    2 LGTGAYGKVFLvrkvgghdaGKLYAMKVLKKativqkaKTAEHTMTERQVLEAVRQsPFLVtlhyAFQ---TDAKLH-LI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-- 309
Cdd:cd05583   78 LDYVNGGELFTHLYQREHFTESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFLPGENDra 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 310 MSFAGTVAWMAPEVIRNEPV--SEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05583  158 YSFCGTIEYMAPEVVRGGSDghDKAVDWWSLGVLTYELLTGASPF 202
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
192-354 2.30e-21

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 94.91  E-value: 2.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 192 AIKKV------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASG 265
Cdd:cd14087   30 AIKMIetkcrgREVCESELNVLRRVRHTNIIQLIEVFETKERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDG 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 266 MNYLHLHKIIHRDLKSPNVLVTH--TDA-VKISDFG--TSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGV 340
Cdd:cd14087  110 VKYLHGLGITHRDLKPENLLYYHpgPDSkIMITDFGlaSTRKKGPNCLMKTTCGTPEYIAPEILLRKPYTQSVDMWAVGV 189
                        170
                 ....*....|....
gi 755554055 341 VLWELLTGEIPYKD 354
Cdd:cd14087  190 IAYILLSGTMPFDD 203
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
170-355 2.48e-21

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 95.07  E-value: 2.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKF--RAEEVAIK--KVREQNETDIK-HLRKLK----HPNIIAFKGV-CTQAPC-----YCIIMEY 234
Cdd:cd06636   21 VEVVGNGTYGQVYKGRHvkTGQLAAIKvmDVTEDEEEEIKlEINMLKkyshHRNIATYYGAfIKKSPPghddqLWLVMEF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITprLLVDW----STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsDKST-- 308
Cdd:cd06636  101 CGAGSVTDLVKNTKGNA--LKEDWiayiCREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVgr 177
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSE-----KVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd06636  178 RNTFIGTPYWMAPEVIACDENPDatydyRSDIWSLGITAIEMAEGAPPLCDM 229
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
173-405 2.65e-21

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 94.37  E-value: 2.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14078   11 IGSGGFAKVKLATHILtgEKVAIKIMDKKAlgddlprvKTEIEALKNLSHQHICRLYHVIETDNKIFMVLEYCPGGELFD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAgrkiTPRLLVDWSTG----IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD--KSTKMSFAGTV 316
Cdd:cd14078   91 YIVA----KDRLSEDEARVffrqIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGLCAKPKGgmDHHLETCCGSP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEIPYKDvDSSAIIWGVGSNSLHlPVPSTCPDGFKILMKQTWQSKPRN 395
Cdd:cd14078  167 AYAAPELIQGKPyIGSEADVWSMGVLLYALLCGFLPFDD-DNVMALYRKIQSGKY-EEPEWLSPSSKLLLDQMLQVDPKK 244
                        250
                 ....*....|
gi 755554055 396 RPSFRQTLMH 405
Cdd:cd14078  245 RITVKELLNH 254
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
149-354 3.14e-21

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 96.04  E-value: 3.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 149 STDYKLQQQDT--WEVPFEEISELqwLGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKH----------LRKLKHPN 214
Cdd:PTZ00263   2 KAAYMFTKPDTssWKLSDFEMGET--LGTGSFGRVRIAKHKGtgEYYAIKCLKKREILKMKQvqhvaqeksiLMELSHPF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 215 IIA-FKGVCTQAPCYcIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVK 293
Cdd:PTZ00263  80 IVNmMCSFQDENRVY-FLLEFVVGGELFTHLRKAGRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVK 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 294 ISDFGTSKELSDKStkMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:PTZ00263 159 VTDFGFAKKVPDRT--FTLCGTPEYLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGYPPFFD 217
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
190-405 3.24e-21

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 94.46  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 190 EVAIKKVREQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYC-IIMEYCAHGQLYEVLRAGRKITPRLLVDW 258
Cdd:cd14165   28 NVAIKIIDKKKAPDdfvekflpreLEILARLNHKSIIKTYEIFETSDGKVyIVMELGVQGDLLEFIKLRGALPEDVARKM 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 259 STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKM----SFAGTVAWMAPEVIRNEPVSEKV 333
Cdd:cd14165  108 FHQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRClRDENGRIvlskTFCGSAAYAAPEVLQGIPYDPRI 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 334 -DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPvPSTCPDG-FKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14165  188 yDIWSLGVILYIMVCGSMPYDDSNVKKMLKIQKEHRVRFP-RSKNLTSeCKDLIYRLLQPDVSQRLCIDEVLSH 260
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
164-345 3.33e-21

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 94.74  E-value: 3.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEIselQWLGSGAQGAVFL--GKFRAEEVAIKKVR----EQNETDIKH----LRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd14046    8 FEEL---QVLGKGAFGQVVKvrNKLDGRYYAIKKIKlrseSKNNSRILRevmlLSRLNHQHVVRYYQAWIERANLYIQME 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITP----RLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL------ 303
Cdd:cd14046   85 YCEKSTLRDLIDSGLFQDTdrlwRLFRQ----ILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGLATSNklnvel 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 304 ---------------SDKSTKMsfAGTVAWMAPEVIRNEPVS--EKVDIWSFGVVLWEL 345
Cdd:cd14046  161 atqdinkstsaalgsSGDLTGN--VGTALYVAPEVQSGTKSTynEKVDMYSLGIIFFEM 217
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
163-352 3.56e-21

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 95.11  E-value: 3.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLG--KFRAEEVAIKKV-------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06658   20 PREYLDSFIKIGEGSTGIVCIAteKHTGKQVAVKKMdlrkqqrRELLFNEVVIMRDYHHENVVDMYNSYLVGDELWVVME 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRkITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SF 312
Cdd:cd06658  100 FLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRkSL 178
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd06658  179 VGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPY 218
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
173-353 3.63e-21

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 95.14  E-value: 3.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA------EEVAIKKVRE------QNETDIKHLRKLKHPNIIAF-----KGVCTQAPcYCIIMEYC 235
Cdd:cd14055    3 VGKGRFAEVWKAKLKQnasgqyETVAVKIFPYeeyaswKNEKDIFTDASLKHENILQFltaeeRGVGLDRQ-YWLITAYH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRagrkitpRLLVDW------STGIASGMNYLH-------LHK--IIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd14055   82 ENGSLQDYLT-------RHILSWedlckmAGSLARGLAHLHsdrtpcgRPKipIAHRDLKSSNILVKNDGTCVLADFGLA 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 301 KELSDKSTKMSFA-----GTVAWMAPEV------IRNEPVSEKVDIWSFGVVLWEL-----LTGEI-PYK 353
Cdd:cd14055  155 LRLDPSLSVDELAnsgqvGTARYMAPEAlesrvnLEDLESFKQIDVYSMALVLWEMasrceASGEVkPYE 224
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
163-405 3.79e-21

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 94.34  E-value: 3.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQ--WLGSGAQGAV--FLGKFRAEEVA---IKKVREQNETD--IKH-----LRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd14106    4 NINEVYTVEstPLGRGKFAVVrkCIHKETGKEYAakfLRKRRRGQDCRneILHeiavlELCKDCPRVVNLHEVYETRSEL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSD 305
Cdd:cd14106   84 ILILELAAGGELQTLLDEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLTSEFPlgdIKLCDFGISRVIGE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPvpstcPDGFKIL- 384
Cdd:cd14106  164 GEEIREILGTPDYVAPEILSYEPISLATDMWSIGVLTYVLLTGHSPFGGDDKQETFLNISQCNLDFP-----EELFKDVs 238
                        250       260
                 ....*....|....*....|....*..
gi 755554055 385 ------MKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14106  239 plaidfIKRLLVKDPEKRLTAKECLEH 265
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
203-405 3.84e-21

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 93.90  E-value: 3.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 203 DIKHLRKLKHPNIIAFKGVCTQAPC-YCIIMEYCAHGQLYE-VLRAG------RKITPRLLVDwstgiasGMNYLHLHKI 274
Cdd:cd14163   50 ELQIVERLDHKNIIHVYEMLESADGkIYLVMELAEDGDVFDcVLHGGplpehrAKALFRQLVE-------AIRYCHGCGV 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 275 IHRDLKSPNVLVTHTDaVKISDFGTSKEL--SDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWELLTGEIP 351
Cdd:cd14163  123 AHRDLKCENALLQGFT-LKLTDFGFAKQLpkGGRELSQTFCGSTAYAAPEVLQGVPHdSRKGDIWSMGVVLYVMLCAQLP 201
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 352 YKDVDSSAIIW----GVgSNSLHLPVPSTCPDgfkiLMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14163  202 FDDTDIPKMLCqqqkGV-SLPGHLGVSRTCQD----LLKRLLEPDMVLRPSIEEVSWH 254
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
163-406 3.90e-21

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 94.33  E-value: 3.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 163 PFEEISELQWLGSGAQGAVFLGK--FRAEEVAIKKVREQNETD-------IKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06646    7 PQHDYELIQRVGSGTYGDVYKARnlHTGELAAVKIIKLEPGDDfsliqqeIFMVKECKHCNIVAYFGSYLSREKLWICME 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK-MSF 312
Cdd:cd06646   87 YCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKrKSF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV---PSTCPDGFKILMK 386
Cdd:cd06646  167 IGTPYWMAPEVAaveKNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKlkdKTKWSSTFHNFVK 246
                        250       260
                 ....*....|....*....|
gi 755554055 387 QTWQSKPRNRPSFRQTLMHL 406
Cdd:cd06646  247 ISLTKNPKKRPTAERLLTHL 266
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
165-405 4.11e-21

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 94.53  E-value: 4.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAEEV--AIKKVREQ----------NETDIKHlrKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd06622    1 DEIEVLDELGKGNYGSVYKVLHRPTGVtmAMKEIRLEldeskfnqiiMELDILH--KAVSPYIVDFYGAFFIEGAVYMCM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHG---QLYEVLRAGRKITPRLLVDWSTGIASGMNYL-HLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsDKST 308
Cdd:cd06622   79 EYMDAGsldKLYAGGVATEGIPEDVLRRITYAVVKGLKFLkEEHNIIHRDVKPTNVLVNGNGQVKLCDFGVSGNL-VASL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSE------KVDIWSFGVVLWELLTGEIPYKDvDSSAIIWGVGSNSLHLPvPSTCPDGF- 381
Cdd:cd06622  158 AKTNIGCQSYMAPERIKSGGPNQnptytvQSDVWSLGLSILEMALGRYPYPP-ETYANIFAQLSAIVDGD-PPTLPSGYs 235
                        250       260
                 ....*....|....*....|....*..
gi 755554055 382 ---KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06622  236 ddaQDFVAKCLNKIPNRRPTYAQLLEH 262
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
147-362 4.31e-21

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 94.40  E-value: 4.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 147 AYSTDYKLQQQDTW-EVPFEEISELQWLgsgaqgavflgkfRAEEvaiKKVREQNETdikhLRKLKHPNIIAF----KGV 221
Cdd:cd14031   22 AFKTVYKGLDTETWvEVAWCELQDRKLT-------------KAEQ---QRFKEEAEM----LKGLQHPNIVRFydswESV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 222 CTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTH-TDAVKISDFG 298
Cdd:cd14031   82 LKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTppIIHRDLKCDNIFITGpTGSVKIGDLG 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 299 TSKeLSDKSTKMSFAGTVAWMAPEVIRnEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 362
Cdd:cd14031  162 LAT-LMRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIY 223
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
173-358 4.53e-21

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 93.93  E-value: 4.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVREQNETDIKHLRKLK-------HPNIIAFKGVCTQAP-CYCIIMEYCAHGQLYE 242
Cdd:cd13987    1 LGEGTYGKVLLAvhKGSGTKMALKFVPKPSTKLKDFLREYNislelsvHPHIIKTYDVAFETEdYYVFAQEYAPYGDLFS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKI----TPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSdkSTKMSFAGTV 316
Cdd:cd13987   81 IIPPQVGLpeerVKRCAAQ----LASALDFMHSKNLVHRDIKPENVLLFDKDCrrVKLCDFGLTRRVG--STVKRVSGTI 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 317 AWMAPEV---IRNEP--VSEKVDIWSFGVVLWELLTGEIPYKDVDSS 358
Cdd:cd13987  155 PYTAPEVceaKKNEGfvVDPSIDVWAFGVLLFCCLTGNFPWEKADSD 201
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
165-405 5.47e-21

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 93.39  E-value: 5.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAqgavFLGKFRAE------EVAIKKV------------REQNETDIkHLRkLKHPNIIAFKGVCTQAP 226
Cdd:cd14186    1 EDFKVLNLLGKGS----FACVYRARslhtglEVAIKMIdkkamqkagmvqRVRNEVEI-HCQ-LKHPSILELYNYFEDSN 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 CYCIIMEYCAHGQLYEVLRAGRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD 305
Cdd:cd14186   75 YVYLVLEMCHNGEMSRYLKNRKKpFTEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKM 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTK-MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYkDVDSSaiiwgvgSNSLHLPV------PSTCP 378
Cdd:cd14186  155 PHEKhFTMCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLVGRPPF-DTDTV-------KNTLNKVVladyemPAFLS 226
                        250       260
                 ....*....|....*....|....*..
gi 755554055 379 DGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14186  227 REAQDLIHQLLRKNPADRLSLSSVLDH 253
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
170-405 6.29e-21

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 93.49  E-value: 6.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVF--LGKFRAEEVAIKKVREQNE------TDIKHLRKLK------HPNIIAFKGVCTQAPCYCIIMEYC 235
Cdd:cd14133    4 LEVLGKGTFGQVVkcYDLLTGEEVALKIIKNNKDyldqslDEIRLLELLNkkdkadKYHIVRLKDVFYFKNHLCIVFELL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHgQLYEVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKSTkmS 311
Cdd:cd14133   84 SQ-NLYEFLKQNKFqyLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLASYSRcqIKIIDFGSSCFLTQRLY--S 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHLPVPSTCPD-GFKILMK 386
Cdd:cd14133  161 YIQSRYYRAPEVILGLPYDEKIDMWSLGCILAELYTGEPLFPGASEvdqlARIIGTIGIPPAHMLDQGKADDeLFVDFLK 240
                        250
                 ....*....|....*....
gi 755554055 387 QTWQSKPRNRPSFRQTLMH 405
Cdd:cd14133  241 KLLEIDPKERPTASQALSH 259
PTKc_Aatyk cd05042
Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs ...
171-398 6.42e-21

Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Aatyk subfamily is also referred to as the lemur tyrosine kinase (Lmtk) subfamily. It consists of Aatyk1 (Lmtk1), Aatyk2 (Lmtk2, Brek), Aatyk3 (Lmtk3), and similar proteins. Aatyk proteins are mostly receptor PTKs (RTKs) containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk1 does not contain a transmembrane segment and is a cytoplasmic (or nonreceptor) kinase. Aatyk proteins are classified as PTKs based on overall sequence similarity and the phylogenetic tree. However, analysis of catalytic residues suggests that Aatyk proteins may be multispecific kinases, functioning also as serine/threonine kinases. They are involved in neural differentiation, nerve growth factor (NGF) signaling, apoptosis, and spermatogenesis. The Aatyk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270638 [Multi-domain]  Cd Length: 269  Bit Score: 93.81  E-value: 6.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGK----FRAEEVAIKKVR------EQNE--TDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05042    1 QEIGNGWFGKVLLGEiysgTSVAQVVVKELKasanpkEQDTflKEGQPYRILQHPNILQCLGQCVEAIPYLLVMEFCDLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKIT-----PRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGtskeLSDKSTKMSFA 313
Cdd:cd05042   81 DLKAYLRSEREHErgdsdTRTLQRMACEVAAGLAHLHKLNFVHSDLALRNCLLTSDLTVKIGDYG----LAHSRYKEDYI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GT-------VAWMAPEVIRN-------EPVSEKVDIWSFGVVLWELLT-GEIPYKDV-DSSAIIWGVGSNSLHLPVPS-- 375
Cdd:cd05042  157 ETddklwfpLRWTAPELVTEfhdrllvVDQTKYSNIWSLGVTLWELFEnGAQPYSNLsDLDVLAQVVREQDTKLPKPQle 236
                        250       260
                 ....*....|....*....|....
gi 755554055 376 -TCPDGFKILMKQTWQSkPRNRPS 398
Cdd:cd05042  237 lPYSDRWYEVLQFCWLS-PEQRPA 259
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
201-405 6.67e-21

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 93.56  E-value: 6.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 201 ETDIKHLRKLKHPNIIAF-KGVCTQAPCYcIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDL 279
Cdd:cd14184   47 ENEVSILRRVKHPNIIMLiEEMDTPAELY-LVMELVKGGDLFDAITSSTKYTERDASAMVYNLASALKYLHGLCIVHRDI 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 280 KSPNVLVTH----TDAVKISDFGTSKELsdKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd14184  126 KPENLLVCEypdgTKSLKLGDFGLATVV--EGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSE 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 356 DS------SAIIWGvgsnSLHLPVP--STCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14184  204 NNlqedlfDQILLG----KLEFPSPywDNITDSAKELISHMLQVNVEARYTAEQILSH 257
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
189-403 6.67e-21

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 93.34  E-value: 6.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 189 EEVAIK----KVREQNETDIKHLRK-------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVD 257
Cdd:cd14070   28 EKVAIKvidkKKAKKDSYVTKNLRRegriqqmIRHPNITQLLDILETENSYYLVMELCPGGNLMHRIYDKKRLEEREARR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA---GTVAWMAPEVIRNEPVSEKVD 334
Cdd:cd14070  108 YIRQLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLSNCAGILGYSDPFStqcGSPAYAAPELLARKKYGPKVD 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 335 IWSFGVVLWELLTGEIPYKdVDSSAIiwgvgsNSLHL--------PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd14070  188 VWSIGVNMYAMLTGTLPFT-VEPFSL------RALHQkmvdkemnPLPTDLSPGAISFLRSLLEPDPLKRPNIKQAL 257
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
207-422 7.33e-21

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 93.85  E-value: 7.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE-VLRAG----RKITPRLLVdwstgIASGMNYLHLHKIIHRDLKS 281
Cdd:cd14091   48 LRYGQHPNIITLRDVYDDGNSVYLVTELLRGGELLDrILRQKffseREASAVMKT-----LTKTVEYLHSQGVVHRDLKP 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 282 PNVL-VTHT---DAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV- 355
Cdd:cd14091  123 SNILyADESgdpESLRICDFGFAKQLrAENGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLAGYTPFASGp 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 356 -DSSAIIW---GVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYF 422
Cdd:cd14091  203 nDTPEVILariGSGKIDLSGGNWDHVSDSAKDLVRKMLHVDPSQRPTAAQVLQHPWIRNRDSLPQRQLTDP 273
STKc_TGFbR1_ACVR1b_ACVR1c cd14143
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I ...
173-345 7.46e-21

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR1, also called Activin receptor-Like Kinase 5 (ALK5), functions as a receptor for TGFbeta and phoshorylates SMAD2/3. TGFbeta proteins are cytokines that regulate cell growth, differentiation, and survival, and are critical in the development and progression of many human cancers. Mutations in TGFbR1 (and TGFbR2) can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. ACVR1b (also called ALK4) and ACVR1c (also called ALK7) act as receptors for activin A and B, respectively. TGFbR1, ACVR1b, and ACVR1c belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like TGFbR1, ACVR1b, and ACVR1c, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The TGFbR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271045 [Multi-domain]  Cd Length: 288  Bit Score: 94.05  E-value: 7.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKV--REQ----NETDIKHLRKLKHPNIIAF-------KGVCTQapcYCIIMEYCAHGQ 239
Cdd:cd14143    3 IGKGRFGEVWRGRWRGEDVAVKIFssREErswfREAEIYQTVMLRHENILGFiaadnkdNGTWTQ---LWLVSDYHEHGS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRkITPRLLVDWSTGIASGMNYLHLH--------KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS 311
Cdd:cd14143   80 LFDYLNRYT-VTVEGMIKLALSIASGLAHLHMEivgtqgkpAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTID 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 312 FA-----GTVAWMAPEVIR-----NEPVSEK-VDIWSFGVVLWEL 345
Cdd:cd14143  159 IApnhrvGTKRYMAPEVLDdtinmKHFESFKrADIYALGLVFWEI 203
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
193-421 8.30e-21

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 93.94  E-value: 8.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 193 IKKVREQNETDIKHLRKL-KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHL 271
Cdd:cd14175   34 IDKSKRDPSEEIEILLRYgQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASSVLHTICKTVEYLHS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 272 HKIIHRDLKSPNVLVT----HTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 346
Cdd:cd14175  114 QGVVHRDLKPSNILYVdesgNPESLRICDFGFAKQLrAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTML 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 347 TGEIPYKDVDSSA---IIWGVGSNSLHLPVPS--TCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETY 421
Cdd:cd14175  194 AGYTPFANGPSDTpeeILTRIGSGKFTLSGGNwnTVSDAAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLPQSQLNH 273
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
164-356 9.03e-21

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 93.59  E-value: 9.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFlgKFRAEE----VAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd07847    3 YEKLSKI---GEGSYGVVF--KCRNREtgqiVAIKKFVESEDDpvikkialrEIRMLKQLKHPNLVNLIEVFRRKRKLHL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRAGRKItPRLLVD---WSTgiASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKS 307
Cdd:cd07847   78 VFEYCDHTVLNELEKNPRGV-PEHLIKkiiWQT--LQAVNFCHKHNCIHRDVKPENILITKQGQIKLCDFGFARILTGPG 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755554055 308 TKMS-FAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWELLTGEI--PYK-DVD 356
Cdd:cd07847  155 DDYTdYVATRWYRAPELLVGDTQyGPPVDVWAIGCVFAELLTGQPlwPGKsDVD 208
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
262-403 9.38e-21

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 92.70  E-value: 9.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 341
Cdd:cd05578  109 IVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGTLATSTSGTKPYMAPEVFMRAGYSFAVDWWSLGVT 188
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755554055 342 LWELLTGEIPYKDVDSSAIIWGVGSNSLH-LPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd05578  189 AYEMLRGKRPYEIHSRTSIEEIRAKFETAsVLYPAGWSEEAIDLINKLLERDPQKRLGDLSDL 251
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
170-352 1.17e-20

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 93.53  E-value: 1.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFL---------GKFRAEEVAIKKVREQNETDIKHLRK----LKH----PNIIAFKGVCTQAPCYCIIM 232
Cdd:cd05613    5 LKVLGTGAYGKVFLvrkvsghdaGKLYAMKVLKKATIVQKAKTAEHTRTerqvLEHirqsPFLVTLHYAFQTDTKLHLIL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTK-M 310
Cdd:cd05613   85 DYINGGELFTHLSQRERFTENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEfLLDENERaY 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755554055 311 SFAGTVAWMAPEVIR--NEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05613  165 SFCGTIEYMAPEIVRggDSGHDKAVDWWSLGVLMYELLTGASPF 208
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
160-406 1.22e-20

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 94.66  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAVFLGKF-------RAEEVAIKKVREqNETDIKH---LRKLK-------HPNIIAFKGVC 222
Cdd:cd05103    2 WEFPRDRLKLGKPLGRGAFGQVIEADAfgidktaTCRTVAVKMLKE-GATHSEHralMSELKilihighHLNVVNLLGAC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQ--APCYcIIMEYCAHGQLYEVLRAGRK-------------------------ITPRL--------------------- 254
Cdd:cd05103   81 TKpgGPLM-VIVEFCKFGNLSAYLRSKRSefvpyktkgarfrqgkdyvgdisvdLKRRLdsitssqssassgfveeksls 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 ---------------------LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL---SDKSTKM 310
Cdd:cd05103  160 dveeeeagqedlykdfltledLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIykdPDYVRKG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPS-TCPDGFKIlMKQT 388
Cdd:cd05103  240 DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSlGASPYPGVKIDEEFCRRLKEGTRMRAPDyTTPEMYQT-MLDC 318
                        330
                 ....*....|....*...
gi 755554055 389 WQSKPRNRPSFRQTLMHL 406
Cdd:cd05103  319 WHGEPSQRPTFSELVEHL 336
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
164-360 1.23e-20

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 94.35  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFLGKFRAEEVAIKK----------VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd06649    7 FERISEL---GAGNGGVVTKVQHKPSGLIMARklihleikpaIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL-HLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSF 312
Cdd:cd06649   84 HMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLrEKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSF 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 313 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 360
Cdd:cd06649  163 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKEL 210
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
200-361 1.34e-20

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 92.77  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 200 NETDIkHlRKLKHPNIIAFKGVCT-QAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIH 276
Cdd:cd13990   53 REYEI-H-KSLDHPRIVKLYDVFEiDTDSFCTVLEYCDGNDLDFYLKQHKSIPEREARSIIMQVVSALKYLNEIKppIIH 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 277 RDLKSPNVLVTHTD---AVKISDFGTSKELSDKSTKMS-------FAGTVAWMAPE--VIRNEP--VSEKVDIWSFGVVL 342
Cdd:cd13990  131 YDLKPGNILLHSGNvsgEIKITDFGLSKIMDDESYNSDgmeltsqGAGTYWYLPPEcfVVGKTPpkISSKVDVWSVGVIF 210
                        170
                 ....*....|....*....
gi 755554055 343 WELLTGEIPYKDVDSSAII 361
Cdd:cd13990  211 YQMLYGRKPFGHNQSQEAI 229
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
173-405 1.37e-20

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 92.48  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGK--FRAEEVAIKKVREQNETDI--KHLRK-------LKHPNIIAFKGVC-TQAPCYcIIMEYCAHGQL 240
Cdd:cd14074   11 LGRGHFAVVKLARhvFTGEKVAVKVIDKTKLDDVskAHLFQevrcmklVQHPNVVRLYEVIdTQTKLY-LILELGDGGDM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YE-VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT-DAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14074   90 YDyIMKHENGLNEDLARKYFRQIVSAISYCHKLHVVHRDLKPENVVFFEKqGLVKLTDFGFSNKFQPGEKLETSCGSLAY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSTCPDgfkiLMKQTWQSKPRN 395
Cdd:cd14074  170 SAPEILLGDEYdAPAVDIWSLGVILYMLVCGQPPFQEANDSETLTMIMDCKYTVPahVSPECKD----LIRRMLIRDPKK 245
                        250
                 ....*....|
gi 755554055 396 RPSFRQTLMH 405
Cdd:cd14074  246 RASLEEIENH 255
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
174-352 1.66e-20

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 92.37  E-value: 1.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQ-GAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP 252
Cdd:cd14195   28 GTGKEyAAKFIKKRRLSSSRRGVSREEIEREVNILREIQHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 253 RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA----VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 328
Cdd:cd14195  108 EEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVpnprIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEP 187
                        170       180
                 ....*....|....*....|....
gi 755554055 329 VSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14195  188 LGLEADMWSIGVITYILLSGASPF 211
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
207-418 2.42e-20

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 92.38  E-value: 2.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd14178   51 LRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILY 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 287 T----HTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK---DVDSS 358
Cdd:cd14178  131 MdesgNPESIRICDFGFAKQLrAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFAngpDDTPE 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554055 359 AIIWGVGSNSLHLPVPS--TCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQ 418
Cdd:cd14178  211 EILARIGSGKYALSGGNwdSISDAAKDIVSKMLHVDPHQRLTAPQVLRHPWIVNREYLSQNQ 272
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
181-352 2.74e-20

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 92.01  E-value: 2.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 181 VFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK----ITPRLLV 256
Cdd:cd08228   30 VALKKVQIFEMMDAKARQDCVKEIDLLKQLNHPNVIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKqkrlIPERTVW 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPVSEKVDI 335
Cdd:cd08228  110 KYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAhSLVGTPYYMSPERIHENGYNFKSDI 189
                        170
                 ....*....|....*..
gi 755554055 336 WSFGVVLWELLTGEIPY 352
Cdd:cd08228  190 WSLGCLLYEMAALQSPF 206
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
231-372 2.88e-20

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 93.52  E-value: 2.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQL-YEVLRAGRKITPRLlVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKST 308
Cdd:cd05615   89 VMEYVNGGDLmYHIQQVGKFKEPQA-VFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEhMVEGVT 167
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 309 KMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372
Cdd:cd05615  168 TRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYP 231
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
173-352 3.13e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 92.39  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKV-------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEV 243
Cdd:cd06657   28 IGEGSTGIVCIATVKSsgKLVAVKKMdlrkqqrRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 244 LRAGRkITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK-STKMSFAGTVAWMAPE 322
Cdd:cd06657  108 VTHTR-MNEEQIAAVCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEvPRRKSLVGTPYWMAPE 186
                        170       180       190
                 ....*....|....*....|....*....|
gi 755554055 323 VIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd06657  187 LISRLPYGPEVDIWSLGIMVIEMVDGEPPY 216
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
170-405 3.25e-20

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 91.49  E-value: 3.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAV-----------FLGKFRAEEVAIKKVREQNETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd14114    7 LEELGTGAFGVVhrcteratgnnFAAKFIMTPHESDKETVRKEIQI--MNQLHHPKLINLHDAFEDDNEMVLILEFLSGG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRA-GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT--HTDAVKISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd14114   85 ELFERIAAeHYKMSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIMCTtkRSNEVKLIDFGLATHLDPKESVKVTTGT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL---PVPSTCPDGfKILMKQTWQSK 392
Cdd:cd14114  165 AEFAAPEIVEREPVGFYTDMWAVGVLSYVLLSGLSPFAGENDDETLRNVKSCDWNFddsAFSGISEEA-KDFIRKLLLAD 243
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd14114  244 PNKRMTIHQALEH 256
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
173-409 3.67e-20

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 91.17  E-value: 3.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVreQNETDIKHLRK-------LKHPNIIAFKGVCTQApcYCIIMEYCAHGQLYEVLR 245
Cdd:cd14068    2 LGDGGFGSVYRAVYRGEDVAVKIF--NKHTSFRLLRQelvvlshLHHPSLVALLAAGTAP--RMLVMELAPKGSLDALLQ 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 A-----GRKITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLV--THTDA---VKISDFGTSKELSDKSTKMSfAGT 315
Cdd:cd14068   78 QdnaslTRTLQHRIALH----VADGLRYLHSAMIIYRDLKPHNVLLftLYPNCaiiAKIADYGIAQYCCRMGIKTS-EGT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGeipykdvdSSAIIWGVG--SNSLHLPVPSTCPD-----------GF 381
Cdd:cd14068  153 PGFRAPEVARgNVIYNQQADVYSFGLLLYDILTC--------GERIVEGLKfpNEFDELAIQGKLPDpvkeygcapwpGV 224
                        250       260
                 ....*....|....*....|....*...
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMHLDIA 409
Cdd:cd14068  225 EALIKDCLKENPQCRPTSAQVFDILNSA 252
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
265-355 4.05e-20

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 91.27  E-value: 4.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 265 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS-DKSTKMSFAGTVAWMAPEVI---RNEPVSEKVDIWSFGV 340
Cdd:cd14118  127 GIEYLHYQKIIHRDIKPSNLLLGDDGHVKIADFGVSNEFEgDDALLSSTAGTPAFMAPEALsesRKKFSGKALDIWAMGV 206
                         90
                 ....*....|....*
gi 755554055 341 VLWELLTGEIPYKDV 355
Cdd:cd14118  207 TLYCFVFGRCPFEDD 221
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
207-403 4.24e-20

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 91.13  E-value: 4.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd14110   53 LRRLSHPRIAQLHSAYLSPRHLVLIEELCSGPELLYNLAERNSYSEAEVTDYLWQILSAVDYLHSRRILHLDLRSENMII 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 287 THTDAVKISDFGTSKELSDKSTKMS--FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYkdvdSSAIIWGV 364
Cdd:cd14110  133 TEKNLLKIVDLGNAQPFNQGKVLMTdkKGDYVETMAPELLEGQGAGPQTDIWAIGVTAFIMLSADYPV----SSDLNWER 208
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755554055 365 GSNSLHLPVP-STCPDGFK----ILMKQTWQSKPRNRPSFRQTL 403
Cdd:cd14110  209 DRNIRKGKVQlSRCYAGLSggavNFLKSTLCAKPWGRPTASECL 252
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
165-345 4.25e-20

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 92.12  E-value: 4.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAEEVAIK---KVREQN---ETDIKHLRKLKHPNIIAF-------KGVCTQapcYCII 231
Cdd:cd14142    5 RQITLVECIGKGRYGEVWRGQWQGESVAVKifsSRDEKSwfrETEIYNTVLLRHENILGFiasdmtsRNSCTQ---LWLI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAgRKITPRLLVDWSTGIASGMNYLHLH--------KIIHRDLKSPNVLVTHTDAVKISDFGTSKEL 303
Cdd:cd14142   82 THYHENGSLYDYLQR-TTLDHQEMLRLALSAASGLVHLHTEifgtqgkpAIAHRDLKSKNILVKSNGQCCIADLGLAVTH 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755554055 304 SDKSTKMSFA-----GTVAWMAPEVIrNEPVS-------EKVDIWSFGVVLWEL 345
Cdd:cd14142  161 SQETNQLDVGnnprvGTKRYMAPEVL-DETINtdcfesyKRVDIYAFGLVLWEV 213
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
194-405 4.28e-20

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 90.88  E-value: 4.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 194 KKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCY------CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMN 267
Cdd:cd14012   39 KKQIQLLEKELESLKKLRHPNLVSYLAFSIERRGRsdgwkvYLLTEYAPGGSLSELLDSVGSVPLDTARRWTLQLLEALE 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 268 YLHLHKIIHRDLKSPNVLV---THTDAVKISDFGTSKELSD--KSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVV 341
Cdd:cd14012  119 YLHRNGVVHKSLHAGNVLLdrdAGTGIVKLTDYSLGKTLLDmcSRGSLDEFKQTYWLPPELAQgSKSPTRKTDVWDLGLL 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 342 LWELLTGeipyKDVdssaiiWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14012  199 FLQMLFG----LDV------LEKYTSPNPVLVSLDLSASLQDFLSKCLSLDPKKRPTALELLPH 252
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
201-405 4.35e-20

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 91.16  E-value: 4.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 201 ETDIKHLRKLKHPNIIAFKGVC-TQAPCYcIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDL 279
Cdd:cd14185   46 ESEILIIKSLSHPNIVKLFEVYeTEKEIY-LILEYVRGGDLFDAIIESVKFTEHDAALMIIDLCEALVYIHSKHIVHRDL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 280 KSPNVLVTH----TDAVKISDFGTSKELSdkSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY--- 352
Cdd:cd14185  125 KPENLLVQHnpdkSTTLKLADFGLAKYVT--GPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFrsp 202
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755554055 353 -KDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14185  203 eRDQEELFQIIQLGHYEFLPPYWDNISEAAKDLISRLLVVDPEKRYTAKQVLQH 256
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
173-352 4.49e-20

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 92.36  E-value: 4.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQ-----NETDIKHLRK--------LKHPNIIAFKGvCTQAPCY-CIIMEYCA 236
Cdd:cd05589    7 LGRGHFGKVLLAEYKptGELFAIKALKKGdiiarDEVESLMCEKrifetvnsARHPFLVNLFA-CFQTPEHvCFVMEYAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLlVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS-FAGT 315
Cdd:cd05589   86 GGDLMMHIHEDVFSEPRA-VFYAACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTStFCGT 164
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05589  165 PEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGESPF 201
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
197-405 5.79e-20

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 90.46  E-value: 5.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 197 REQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIH 276
Cdd:cd14188   45 REKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILH 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 277 RDLKSPNVLVTHTDAVKISDFGTSKELSD-KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV 355
Cdd:cd14188  125 RDLKLGNFFINENMELKVGDFGLAARLEPlEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETT 204
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 356 DSSAIIWGVGSNSLHLpvPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14188  205 NLKETYRCIREARYSL--PSSLLAPAKHLIASMLSKNPEDRPSLDEIIRH 252
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
188-420 7.23e-20

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 91.23  E-value: 7.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 188 AEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMN 267
Cdd:cd14177   33 AVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTELMKGGELLDRILRQKFFSEREASAVLYTITKTVD 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 268 YLHLHKIIHRDLKSPNVLV----THTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 342
Cdd:cd14177  113 YLHCQGVVHRDLKPSNILYmddsANADSIRICDFGFAKQLrGENGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 343 WELLTGEIPYKDVDSSA---IIWGVGSNSLHLPVPS--TCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATP 417
Cdd:cd14177  193 YTMLAGYTPFANGPNDTpeeILLRIGSGKFSLSGGNwdTVSDAAKDLLSHMLHVDPHQRYTAEQVLKHSWIACRDQLPHY 272

                 ...
gi 755554055 418 QET 420
Cdd:cd14177  273 QLN 275
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
173-397 7.85e-20

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 90.79  E-value: 7.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAV-FLGKFRAEEVAIKKVREQ---------NETDIKHLR-------------------KLKHPNIIAFKGVCT 223
Cdd:cd14067    1 LGQGGSGTViYRARYQGQPVAVKRFHIKkckkrtdgsADTMLKHLRaadamknfsefrqeasmlhSLQHPCIVYLIGISI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 QAPCYCiiMEYCAHGQLYEVLRAGRK------ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA-----V 292
Cdd:cd14067   81 HPLCFA--LELAPLGSLNTVLEENHKgssfmpLGHMLTFKIAYQIAAGLAYLHKKNIIFCDLKSDNILVWSLDVqehinI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 293 KISDFGTSKElSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPykdvdssaiiwGVGSNSLHL- 371
Cdd:cd14067  159 KLSDYGISRQ-SFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP-----------SLGHHQLQIa 226
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 755554055 372 --------PVPSTcPDGFKI-----LMKQTWQSKPRNRP 397
Cdd:cd14067  227 kklskgirPVLGQ-PEEVQFfrlqaLMMECWDTKPEKRP 264
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
197-362 8.06e-20

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 90.52  E-value: 8.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 197 REQNETDIKHLRKLKHPNIIAF----KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLH 272
Cdd:cd14032   44 RQRFKEEAEMLKGLQHPNIVRFydfwESCAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTR 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 273 K--IIHRDLKSPNVLVTH-TDAVKISDFGTSKeLSDKSTKMSFAGTVAWMAPEVIRnEPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd14032  124 TppIIHRDLKCDNIFITGpTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSE 201
                        170
                 ....*....|...
gi 755554055 350 IPYKDVDSSAIIW 362
Cdd:cd14032  202 YPYSECQNAAQIY 214
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
195-352 8.38e-20

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 90.41  E-value: 8.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 195 KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE-VLRAGRKITPRLLVDWSTGIASGMNYLHLHK 273
Cdd:cd14192   43 KEREEVKNEINIMNQLNHVNLIQLYDAFESKTNLTLIMEYVDGGELFDrITDESYQLTELDAILFTRQICEGVHYLHQHY 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 274 IIHRDLKSPNVL-VTHT-DAVKISDFGTSKELSDKST-KMSFaGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEI 350
Cdd:cd14192  123 ILHLDLKPENILcVNSTgNQIKIIDFGLARRYKPREKlKVNF-GTPEFLAPEVVNYDFVSFPTDMWSVGVITYMLLSGLS 201

                 ..
gi 755554055 351 PY 352
Cdd:cd14192  202 PF 203
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
173-406 8.91e-20

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 90.42  E-value: 8.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEV--AIKKVREQNETDIKHLRK--------LKHPNIIAF---KGVCTQAPCY--CIIMEYCAH 237
Cdd:cd14037   11 LAEGGFAHVYLVKTSNGGNraALKRVYVNDEHDLNVCKReieimkrlSGHKNIVGYidsSANRSGNGVYevLLLMEYCKG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFG--TSKELS-DKSTKM 310
Cdd:cd14037   91 GGVIDLMnqRLQTGLTESEILKIFCDVCEAVAAMHYLKppLIHRDLKVENVLISDSGNYKLCDFGsaTTKILPpQTKQGV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFA-------GTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIwgvgSNSLHLPVPSTCPDG 380
Cdd:cd14037  171 TYVeedikkyTTLQYRAPEMIdlyRGKPITEKSDIWALGCLLYKLCFYTTPFEESGQLAIL----NGNFTFPDNSRYSKR 246
                        250       260
                 ....*....|....*....|....*.
gi 755554055 381 FKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd14037  247 LHKLIRYMLEEDPEKRPNIYQVSYEA 272
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
194-354 1.45e-19

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 89.53  E-value: 1.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 194 KKVREQN----ETDIKHLRKlKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 269
Cdd:PHA03390  47 KIIKAKNfnaiEPMVHQLMK-DNPNFIKLYYSVTTLKGHVLIMDYIKDGDLFDLLKKEGKLSEAEVKKIIRQLVEALNDL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 270 HLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSKELSDKSTkmsFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:PHA03390 126 HKHNIIHNDIKLENVLYDrAKDRIYLCDYGLCKIIGTPSC---YDGTLDYFSPEKIKGHNYDVSFDWWAVGVLTYELLTG 202

                 ....*.
gi 755554055 349 EIPYKD 354
Cdd:PHA03390 203 KHPFKE 208
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
160-357 1.62e-19

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 90.12  E-value: 1.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPFEEISELQWLGSGAQGAV--FLGKFRAEEVAIKKVR-EQNETDIKHL--------RKLKHPNIIAFKG-VCTQAPC 227
Cdd:cd06616    1 YEFTAEDLKDLGEIGRGAFGTVnkMLHKPSGTIMAVKRIRsTVDEKEQKRLlmdldvvmRSSDCPYIVKFYGaLFREGDC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 YcIIMEYCA------HGQLYEVLRagRKITPRLLVDWSTGIASGMNYL-HLHKIIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd06616   81 W-ICMELMDisldkfYKYVYEVLD--SVIPEEILGKIAVATVKALNYLkEELKIIHRDVKPSNILLDRNGNIKLCDFGIS 157
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 301 KELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI----WSFGVVLWELLTGEIPYKDVDS 357
Cdd:cd06616  158 GQLVDSIAKTRDAGCRPYMAPERIDPSASRDGYDVrsdvWSLGITLYEVATGKFPYPKWNS 218
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
164-393 1.82e-19

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 90.09  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVFL-------GKFraeeVAIKKVREQNETD------------IKHLRKLKHPNIIAFKGVCT- 223
Cdd:cd07862    3 YECVAEI---GEGAYGKVFKardlkngGRF----VALKRVRVQTGEEgmplstirevavLRHLETFEHPNVVRLFDVCTv 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 224 ----QAPCYCIIMEYCAHGQLYEVLRAGRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG 298
Cdd:cd07862   76 srtdRETKLTLVFEHVDQDLTTYLDKVPEPgVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 299 TSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK---DVDSSAIIWGVgsnsLHLPVPS 375
Cdd:cd07862  156 LARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRgssDVDQLGKILDV----IGLPGEE 231
                        250
                 ....*....|....*...
gi 755554055 376 TCPDGFKiLMKQTWQSKP 393
Cdd:cd07862  232 DWPRDVA-LPRQAFHSKS 248
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
151-352 2.46e-19

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 88.88  E-value: 2.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 151 DYKLqqqdTWEVpfeeiselqwLGSGAQGAVF--LGKFRAEEVAIKKVRE----QNETDIkHLRKLKHPNIIA----FKG 220
Cdd:cd14089    1 DYTI----SKQV----------LGLGINGKVLecFHKKTGEKFALKVLRDnpkaRREVEL-HWRASGCPHIVRiidvYEN 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 221 VCTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT--DAV-KIS 295
Cdd:cd14089   66 TYQGRKCLLVVMECMEGGELFSRIqeRADSAFTEREAAEIMRQIGSAVAHLHSMNIAHRDLKPENLLYSSKgpNAIlKLT 145
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 296 DFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14089  146 DFGFAKETTTKKSLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 202
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
159-349 3.53e-19

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 90.05  E-value: 3.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 159 TWEVPfEEISELQWLGSGAQGAV---FLGKFRaEEVAIKKVRE--QNETDIKH-------LRKLKHPNIIAFKGVCTQAP 226
Cdd:cd07851   10 VWEVP-DRYQNLSPVGSGAYGQVcsaFDTKTG-RKVAIKKLSRpfQSAIHAKRtyrelrlLKHMKHENVIGLLDVFTPAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 227 -------CYcIIMEYCAhGQLYEVLRAgRKITP---RLLVdwsTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISD 296
Cdd:cd07851   88 sledfqdVY-LVTHLMG-ADLNNIVKC-QKLSDdhiQFLV---YQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILD 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 297 FGTSKELSDKSTkmsfaGTVA--W-MAPEVIRNE-PVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd07851  162 FGLARHTDDEMT-----GYVAtrWyRAPEIMLNWmHYNQTVDIWSVGCIMAELLTGK 213
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
173-352 3.59e-19

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 88.14  E-value: 3.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVF-----------LGKFRAEEVAikKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14191   10 LGSGKFGQVFrlvekktkkvwAGKFFKAYSA--KEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEMVSGGELF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 E-VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT--DAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd14191   88 ErIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKtgTKIKLIDFGLARRLENAGSLKVLFGTPEF 167
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 319 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14191  168 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPF 201
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
207-354 4.21e-19

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 88.81  E-value: 4.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL-YEVLRAG-RKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNV 284
Cdd:cd05607   56 LEKVNSPFIVSLAYAFETKTHLCLVMSLMNGGDLkYHIYNVGeRGIEMERVIFYSAQITCGILHLHSLKIVYRDMKPENV 135
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 285 LVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd05607  136 LLDDNGNCRLSDLGLAVEVKEGKPITQRAGTNGYMAPEILKEESYSYPVDWFAMGCSIYEMVAGRTPFRD 205
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
167-349 4.22e-19

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 88.82  E-value: 4.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISElqwlgsGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVC---TQAPCYcIIM 232
Cdd:cd07843   13 IEE------GTYGVVYRARDKKtgEIVALKKLKMEKEKEgfpitslreINILLKLQHPNIVTVKEVVvgsNLDKIY-MVM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHG--QLYEVLR-----AGRK-ITPRLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS 304
Cdd:cd07843   86 EYVEHDlkSLMETMKqpflqSEVKcLMLQLL--------SGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAREYG 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 305 DKSTKM-SFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWELLTGE 349
Cdd:cd07843  158 SPLKPYtQLVVTLWYRAPELLLGAKEySTAIDMWSVGCIFAELLTKK 204
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
173-358 4.23e-19

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 88.69  E-value: 4.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIK---KVREQN---ETDIKHLRKLKHPNIIAF-----KGVCTQAPCYcIIMEYCAHGQLY 241
Cdd:cd14144    3 VGKGRYGEVWKGKWRGEKVAVKiffTTEEASwfrETEIYQTVLMRHENILGFiaadiKGTGSWTQLY-LITDYHENGSLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRaGRKITPRLLVDWSTGIASGMNYLHLH--------KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA 313
Cdd:cd14144   82 DFLR-GNTLDTQSMLKLAYSAACGLAHLHTEifgtqgkpAIAHRDIKSKNILVKKNGTCCIADLGLAVKFISETNEVDLP 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 314 -----GTVAWMAPEVI-----RNEPVSEKV-DIWSFGVVLWEL----LTG------EIPYKDVDSS 358
Cdd:cd14144  161 pntrvGTKRYMAPEVLdeslnRNHFDAYKMaDMYSFGLVLWEIarrcISGgiveeyQLPYYDAVPS 226
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
184-405 4.29e-19

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 88.13  E-value: 4.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAIkkvreQNETDIkhLRKLKHPNIIAF-KGVCTQAPCYcIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI 262
Cdd:cd14183   42 SKCRGKEHMI-----QNEVSI--LRRVKHPNIVLLiEEMDMPTELY-LVMELVKGGDLFDAITSTNKYTERDASGMLYNL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 263 ASGMNYLHLHKIIHRDLKSPNVLV-THTD---AVKISDFGTSKELSdkSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 338
Cdd:cd14183  114 ASAIKYLHSLNIVHRDIKPENLLVyEHQDgskSLKLGDFGLATVVD--GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAA 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 339 GVVLWELLTGEIPYKDV--DSSAIIWGVGSNSLHLPVP--STCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14183  192 GVITYILLCGFPPFRGSgdDQEVLFDQILMGQVDFPSPywDNVSDSAKELITMMLQVDVDQRYSALQVLEH 262
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
157-354 5.10e-19

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 88.11  E-value: 5.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 157 QDTWEVPFEEISELqwlGSGAQGAVFLGKFRAEE--VAIKKV------REQNETDIKHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd14113    2 KDNFDSFYSEVAEL---GRGRFSVVKKCDQRGTKraVATKFVnkklmkRDQVTHELGVLQSLQHPQLVGLLDTFETPTSY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSD 305
Cdd:cd14113   79 ILVLEMADQGRLLDYVVRWGNLTEEKIRFYLREILEALQYLHNCRIAHLDLKPENILVDQSLSkptIKLADFGDAVQLNT 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755554055 306 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:cd14113  159 TYYIHQLLGSPEFAAPEIILGNPVSLTSDLWSIGVLTYVLLSGVSPFLD 207
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
151-348 5.54e-19

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 88.76  E-value: 5.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 151 DYKLQQQDTWEVPFEEISELqwlGSGAQGAVFL------GKFraeeVAIKKVREQ--------NETDI-KHLRKlKHP-- 213
Cdd:cd14210    2 DYKVVLGDHIAYRYEVLSVL---GKGSFGQVVKcldhktGQL----VAIKIIRNKkrfhqqalVEVKIlKHLND-NDPdd 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 214 --NIIAFKGVCTQAPCYCIIMEYcaHGQ-LYEVLRAG--RKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH 288
Cdd:cd14210   74 khNIVRYKDSFIFRGHLCIVFEL--LSInLYELLKSNnfQGLSLSLIRKFAKQILQALQFLHKLNIIHCDLKPENILLKQ 151
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 289 --TDAVKISDFGTSkelsdkstkmSFAGTVAWM--------APEVIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd14210  152 psKSSIKVIDFGSS----------CFEGEKVYTyiqsrfyrAPEVILGLPYDTAIDMWSLGCILAELYTG 211
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
173-409 5.58e-19

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 88.02  E-value: 5.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKVREQN--------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14169   11 LGEGAFSEVVLAQERGSQrlVALKCIPKKAlrgkeamvENEIAVLRRINHENIVSLEDIYESPTHLYLAMELVTGGELFD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 -VLRAG---RKITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVT---HTDAVKISDFGTSKeLSDKSTKMSFAGT 315
Cdd:cd14169   91 rIIERGsytEKDASQLIGQ----VLQAVKYLHQLGIVHRDLKPENLLYAtpfEDSKIMISDFGLSK-IEAQGMLSTACGT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP--STCPDGFKILMKQTWQSKP 393
Cdd:cd14169  166 PGYVAPELLEQKPYGKAVDVWAIGVISYILLCGYPPFYDENDSELFNQILKAEYEFDSPywDDISESAKDFIRHLLERDP 245
                        250
                 ....*....|....*.
gi 755554055 394 RNRPSFRQTLMHLDIA 409
Cdd:cd14169  246 EKRFTCEQALQHPWIS 261
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
173-349 7.32e-19

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 88.13  E-value: 7.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVR--EQNET-------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd07848    9 VGEGAYGVVLKCRHKEtkEIVAIKKFKdsEENEEvkettlrELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK--MSFAGTVAWM 319
Cdd:cd07848   89 LLEEMPNGVPPEKVRSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGSNAnyTEYVATRWYR 168
                        170       180       190
                 ....*....|....*....|....*....|
gi 755554055 320 APEVIRNEPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd07848  169 SPELLLGAPYGKAVDMWSVGCILGELSDGQ 198
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
258-400 7.55e-19

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 88.01  E-value: 7.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPVSEKVDIW 336
Cdd:cd05608  110 YTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAVELKDGQTKTkGYAGTPGFMAPELLLGEEYDYSVDYF 189
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 337 SFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVpsTCPDGF----KILMKQTWQSKPRNRPSFR 400
Cdd:cd05608  190 TLGVTLYEMIAARGPFRARGEKVENKELKQRILNDSV--TYSEKFspasKSICEALLAKDPEKRLGFR 255
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
229-400 8.29e-19

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 87.58  E-value: 8.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYCAHGQL-YEVLRAGRKITPRL-LVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd05577   69 CLVLTLMNGGDLkYHIYNVGTRGFSEArAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLAVEFKGG 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAGTVAWMAPEVIRNE-PVSEKVDIWSFGVVLWELLTGEIPYKD----VDSSAIiwgvgsNSLHLPVPSTCPDGF 381
Cdd:cd05577  149 KKIKGRVGTHGYMAPEVLQKEvAYDFSVDWFALGCMLYEMIAGRSPFRQrkekVDKEEL------KRRTLEMAVEYPDSF 222
                        170       180
                 ....*....|....*....|...
gi 755554055 382 ----KILMKQTWQSKPRNRPSFR 400
Cdd:cd05577  223 speaRSLCEGLLQKDPERRLGCR 245
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
166-405 8.92e-19

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 87.85  E-value: 8.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELqwLGSGAQGAVFLGK-FRAEEVAIKKV-------REQNETDIKHLRKLKH-PNIIAFKGVCTQA------PCYCI 230
Cdd:cd06637    9 ELVEL--VGNGTYGQVYKGRhVKTGQLAAIKVmdvtgdeEEEIKQEINMLKKYSHhRNIATYYGAFIKKnppgmdDQLWL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLR--AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsDKST 308
Cdd:cd06637   87 VMEFCGAGSVTDLIKntKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 --KMSFAGTVAWMAPEVIRNEPVSE-----KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd06637  166 grRNTFIGTPYWMAPEVIACDENPDatydfKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKF 245
                        250       260
                 ....*....|....*....|....
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd06637  246 QSFIESCLVKNHSQRPSTEQLMKH 269
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
173-352 8.95e-19

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 87.84  E-value: 8.95e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKVREQ------------NETDIkhLRKLKHPNII----AFKgvcTQAPCYcIIMEY 234
Cdd:cd14209    9 LGTGSFGRVMLVRHKETGnyYAMKILDKQkvvklkqvehtlNEKRI--LQAINFPFLVkleySFK---DNSNLY-MVMEY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKStkMSFAG 314
Cdd:cd14209   83 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFGFAKRVKGRT--WTLCG 160
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14209  161 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPF 198
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
198-405 1.11e-18

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 87.33  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 198 EQNETDIKHLRKLKHPNIIAFKGVC---TQAPCYcIIMEYCAHGQLYEV--LRAGRKITPRLlvdWSTGIASGMNYLHLH 272
Cdd:cd14199   70 ERVYQEIAILKKLDHPNVVKLVEVLddpSEDHLY-MVFELVKQGPVMEVptLKPLSEDQARF---YFQDLIKGIEYLHYQ 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 273 KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS-FAGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd14199  146 KIIHRDVKPSNLLVGEDGHIKIADFGVSNEFEGSDALLTnTVGTPAFMAPETLsetRKIFSGKALDVWAMGVTLYCFVFG 225
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 349 EIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14199  226 QCPFMDERILSLHSKIKTQPLEFPDQPDISDDLKDLLFRMLDKNPESRISVPEIKLH 282
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
174-353 1.11e-18

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 88.11  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 174 GSGAQGAVFLGK----FRAEEVAIKKVREQNET----------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIM--EYCAH 237
Cdd:cd07842    9 GRGTYGRVYKAKrkngKDGKEYAIKKFKGDKEQytgisqsacrEIALLRELKHENVVSLVEVFLEHADKSVYLlfDYAEH 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 gQLYEVL----RAGRKITPRLLVD---WStgIASGMNYLHLHKIIHRDLKSPNVLVT----HTDAVKISDFGTSKeLSDK 306
Cdd:cd07842   89 -DLWQIIkfhrQAKRVSIPPSMVKsllWQ--ILNGIHYLHSNWVLHRDLKPANILVMgegpERGVVKIGDLGLAR-LFNA 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 307 STKMSFAG-----TVAWMAPEVI---RNepVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd07842  165 PLKPLADLdpvvvTIWYRAPELLlgaRH--YTKAIDIWAIGCIFAELLTLEPIFK 217
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
167-352 1.25e-18

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 86.90  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVF--LGKFRAEEVAIKKVREQNETD-------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd14190    6 IHSKEVLGGGKFGKVHtcTEKRTGLKLAAKVINKQNSKDkemvlleIQVMNQLNHRNLIQLYEAIETPNEIVLFMEYVEG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEvlRAGRKITPRLLVD---WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELS-DKSTKMS 311
Cdd:cd14190   86 GELFE--RIVDEDYHLTEVDamvFVRQICEGIQFMHQMRVLHLDLKPENILCVNRTGhqVKIIDFGLARRYNpREKLKVN 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 755554055 312 FaGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14190  164 F-GTPEFLSPEVVNYDQVSFPTDMWSMGVITYMLLSGLSPF 203
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
169-416 1.39e-18

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 87.76  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAF--------KGVCTQAPCYC 229
Cdd:cd07866   12 ILGKLGEGTFGEVYKARQIKtgRVVALKKILMHNEKDgfpitalreIKILKKLKHPNVVPLidmaverpDKSKRKRGSVY 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHgQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd07866   92 MVTPYMDH-DLSGLLENPSvKLTESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLARPYDGPPP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVA-----------WM-APEVIRNEP-VSEKVDIWSFGVVLWELLTGE--IPYK-DVDSSAIIWG-VGSnslhl 371
Cdd:cd07866  171 NPKGGGGGGtrkytnlvvtrWYrPPELLLGERrYTTAVDIWGIGCVFAEMFTRRpiLQGKsDIDQLHLIFKlCGT----- 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 372 PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLAT 416
Cdd:cd07866  246 PTEETWPGWRSLPGCEGVHSFTNYPRTLEERFGKLGPEGLDLLSK 290
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
164-358 1.50e-18

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 88.55  E-value: 1.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQ---NETDIKHLRKLKH--------PNIIAFKGVCTQAPCYCI 230
Cdd:cd05618   19 LQDFDLLRVIGRGSYAKVLLVRLKKTEriYAMKVVKKElvnDDEDIDWVQTEKHvfeqasnhPFLVGLHSCFQTESRLFF 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTK 309
Cdd:cd05618   99 VIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEgLRPGDTT 178
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755554055 310 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS 358
Cdd:cd05618  179 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 227
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
173-372 1.94e-18

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 87.31  E-value: 1.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVREQN---ETDI------KHLRKLKHPNIIAFKGVCT-QAPCYCI-IMEYCAHGQ 239
Cdd:cd05620    3 LGKGSFGKVLLAelKGKGEYFAVKALKKDVvliDDDVectmveKRVLALAWENPFLTHLYCTfQTKEHLFfVMEFLNGGD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 L-YEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVA 317
Cdd:cd05620   83 LmFHIQDKGRFDLYRATF-YAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKEnVFGDNRASTFCGTPD 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 372
Cdd:cd05620  162 YIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYP 216
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
173-355 2.03e-18

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 86.63  E-value: 2.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKK--VREQ----NETDIKHLRKLKHPNIIAF-----KGVCTQAPCYcIIMEYCAHGQLY 241
Cdd:cd14220    3 IGKGRYGEVWMGKWRGEKVAVKVffTTEEaswfRETEIYQTVLMRHENILGFiaadiKGTGSWTQLY-LITDYHENGSLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGrKITPRLLVDWSTGIASGMNYLHLH--------KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF- 312
Cdd:cd14220   82 DFLKCT-TLDTRALLKLAYSAACGLCHLHTEiygtqgkpAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDVp 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 313 ----AGTVAWMAPEVIrNEPVSEK-------VDIWSFGVVLWEL----LTG------EIPYKDV 355
Cdd:cd14220  161 lntrVGTKRYMAPEVL-DESLNKNhfqayimADIYSFGLIIWEMarrcVTGgiveeyQLPYYDM 223
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
173-405 2.44e-18

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 85.75  E-value: 2.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLR----------------KLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd14005    8 LGKGGFGTVYSGVRIRDglPVAVKFVPKSRVTEWAMINgpvpvpleialllkasKPGVPGVIRLLDWYERPDGFLLIMER 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 -----------CAHGQLYEvlRAGRKItprllvdWSTGIASGMNyLHLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSKE 302
Cdd:cd14005   88 pepcqdlfdfiTERGALSE--NLARII-------FRQVVEAVRH-CHQRGVLHRDIKDENLLINlRTGEVKLIDFGCGAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 303 LSDkSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEIPYKDvDSSAIIWGVgsnsLHLPVPST-CPDg 380
Cdd:cd14005  158 LKD-SVYTDFDGTRVYSPPEWIRhGRYHGRPATVWSLGILLYDMLCGDIPFEN-DEQILRGNV----LFRPRLSKeCCD- 230
                        250       260
                 ....*....|....*....|....*
gi 755554055 381 fkiLMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14005  231 ---LISRCLQFDPSKRPSLEQILSH 252
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
169-405 2.61e-18

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 85.51  E-value: 2.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVF--LGKFRAEEVAIKKV---------REQNETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd13997    4 ELEQIGSGSFSEVFkvRSKVDGCLYAVKKSkkpfrgpkeRARALREVEAHAALGqHPNIVRYYSSWEEGGHLYIQMELCE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVL-RAGR--KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSdkSTKMSFA 313
Cdd:cd13997   84 NGSLQDALeELSPisKLSEAEVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLE--TSGDVEE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 GTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWELLTG-EIPYKDVDSSAIIWGvgsnslHLPVPSTCP--DGFKILMKQTW 389
Cdd:cd13997  162 GDSRYLAPELLNENYThLPKADIFSLGVTVYEAATGePLPRNGQQWQQLRQG------KLPLPPGLVlsQELTRLLKVML 235
                        250
                 ....*....|....*.
gi 755554055 390 QSKPRNRPSFRQTLMH 405
Cdd:cd13997  236 DPDPTRRPTADQLLAH 251
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
173-356 2.63e-18

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 87.29  E-value: 2.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKVR-------EQNETDIKHLRKL----KHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:cd05619   13 LGKGSFGKVFLAELKGTNqfFAIKALKkdvvlmdDDVECTMVEKRVLslawEHPFLTHLFCTFQTKENLFFVMEYLNGGD 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 L-YEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE--LSDKSTKmSFAGTV 316
Cdd:cd05619   93 LmFHIQSCHKFDLPRATF-YAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKEnmLGDAKTS-TFCGTP 170
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd05619  171 DYIAPEILLGQKYNTSVDWWSFGVLLYEMLIGQSPFHGQD 210
PK_GC-2D cd14043
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain ...
180-402 2.66e-18

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-2D is allso called Retinal Guanylyl Cyclase 1 (RETGC-1) or Rod Outer Segment membrane Guanylate Cyclase (ROS-GC). It is found in the photoreceptors of the retina where it anchors the reciprocal feedback loop between calcium and cGMP, which regulates the dark, light, and recovery phases in phototransduction. It is also found in other sensory neurons and may be a universal transduction component that plays a role in the perception of all senses. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-2D subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270945 [Multi-domain]  Cd Length: 267  Bit Score: 85.92  E-value: 2.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 180 AVFLGKFRAEEvaIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAgrkitPRLLVDWS 259
Cdd:cd14043   25 WVWLKKFPGGS--HTELRPSTKNVFSKLRELRHENVNLFLGLFVDCGILAIVSEHCSRGSLEDLLRN-----DDMKLDWM 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 260 ------TGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--STKMSFAGTVAWMAPEVIRNEPVSE 331
Cdd:cd14043   98 fkssllLDLIKGMRYLHHRGIVHGRLKSRNCVVDGRFVLKITDYGYNEILEAQnlPLPEPAPEELLWTAPELLRDPRLER 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 332 KV----DIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSlHLPVPSTCPDGFKI----LMKQTWQSKPRNRPSFRQ 401
Cdd:cd14043  178 RGtfpgDVFSFAIIMQEVIVRGAPYCMLGLSPeeIIEKVRSPP-PLCRPSVSMDQAPLeciqLMKQCWSEAPERRPTFDQ 256

                 .
gi 755554055 402 T 402
Cdd:cd14043  257 I 257
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
166-347 2.70e-18

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 86.32  E-value: 2.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd07861    1 DYTKIEKIGEGTYGVVYKGRNKKtgQIVAMKKIRLESEEEgvpstaireISLLKELQHPNIVCLEDVLMQENRLYLVFEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 --CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF 312
Cdd:cd07861   81 lsMDLKKYLDSLPKGKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGIPVRVYTH 160
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 313 AGTVAWM-APEVIRNEP-VSEKVDIWSFGVVLWELLT 347
Cdd:cd07861  161 EVVTLWYrAPEVLLGSPrYSTPVDIWSIGTIFAEMAT 197
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
184-405 3.96e-18

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 85.74  E-value: 3.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAikKVREQNETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL--------RAGRKITPRL 254
Cdd:cd14182   42 GSFSPEEVQ--ELREATLKEIDILRKVSgHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLtekvtlseKETRKIMRAL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 255 LvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR------NEP 328
Cdd:cd14182  120 L--------EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPGYLAPEIIEcsmddnHPG 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 329 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPS--TCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14182  192 YGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEwdDRSDTVKDLISRFLVVQPQKRYTAEEALAH 270
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
173-397 4.23e-18

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 85.23  E-value: 4.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL-----GKFRAeevAIKKVREQNEtdiKHLRKL-----------KHPNIIAFKGVCTQ-------APCYC 229
Cdd:cd13975    8 LGRGQYGVVYAcdswgGHFPC---ALKSVVPPDD---KHWNDLalefhytrslpKHERIVSLHGSVIDysygggsSIAVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCaHGQLYEVLRAGRKITPRLLVdwSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTk 309
Cdd:cd13975   82 LIMERL-HRDLYTGIKAGLSLEERLQI--ALDVVEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLGFCKPEAMMSG- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 mSFAGTVAWMAPEVIRNEpVSEKVDIWSFGVVLWELLTGEI----PYKDVDSSAIIWGV---GSNSLHLPVPStcpDGFK 382
Cdd:cd13975  158 -SIVGTPIHMAPELFSGK-YDNSVDVYAFGILFWYLCAGHVklpeAFEQCASKDHLWNNvrkGVRPERLPVFD---EECW 232
                        250
                 ....*....|....*
gi 755554055 383 ILMKQTWQSKPRNRP 397
Cdd:cd13975  233 NLMEACWSGDPSQRP 247
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
164-352 4.25e-18

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 85.35  E-value: 4.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFlgkfRAEEVA--------IKKVREQNETD-----IKHLRKLKHPNIIAFKGVCTQAPCYCI 230
Cdd:cd14193    3 YYNVNKEEILGGGRFGQVH----KCEEKSsglklaakIIKARSQKEKEevkneIEVMNQLNHANLIQLYDAFESRNDIVL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQLYE-VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA--VKISDFGTSKELSDKS 307
Cdd:cd14193   79 VMEYVDGGELFDrIIDENYNLTELDTILFIKQICEGIQYMHQMYILHLDLKPENILCVSREAnqVKIIDFGLARRYKPRE 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 308 T-KMSFaGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14193  159 KlRVNF-GTPEFLAPEVVNYEFVSFPTDMWSLGVIAYMLLSGLSPF 203
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
230-442 5.15e-18

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 88.39  E-value: 5.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYCAHGQLYEVLRAgRKITPRLLVDWSTG-----IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK--- 301
Cdd:PTZ00283 116 LVLDYANAGDLRQEIKS-RAKTNRTFREHEAGllfiqVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLGDFGFSKmya 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 -ELSDKSTKmSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHlPVPSTCPDG 380
Cdd:PTZ00283 195 aTVSDDVGR-TFCGTPYYVAPEIWRRKPYSKKADMFSLGVLLYELLTLKRPFDGENMEEVMHKTLAGRYD-PLPPSISPE 272
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 381 FKILMKQTWQSKPRNRPSfRQTLMHLDIAS--ADVLATPQETYFKSQAEWREEVKKHFEKIKSE 442
Cdd:PTZ00283 273 MQEIVTALLSSDPKRRPS-SSKLLNMPICKlfISGLLEIVQTQPGFSGPLRDTISRQIQQTKQL 335
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
192-407 5.20e-18

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 85.43  E-value: 5.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 192 AIKKV-------REQNETDIKHLRKLKHPNII-----AFKGVCTQAPCYCIIMEYCAHGQLYEVLRA----GRKITPRLL 255
Cdd:cd13986   29 ALKKIlchskedVKEAMREIENYRLFNHPNILrlldsQIVKEAGGKKEVYLLLPYYKRGSLQDEIERrlvkGTFFPEDRI 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 256 VDWSTGIASGMNYLHLHKII---HRDLKSPNVLVTHTDAVKISDFG----------TSKELSDKSTKMSFAGTVAWMAPE 322
Cdd:cd13986  109 LHIFLGICRGLKAMHEPELVpyaHRDIKPGNVLLSEDDEPILMDLGsmnparieieGRREALALQDWAAEHCTMPYRAPE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 323 ---VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV----DSSAIiwGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRN 395
Cdd:cd13986  189 lfdVKSHCTIDEKTDIWSLGCTLYALMYGESPFERIfqkgDSLAL--AVLSGNYSFPDNSRYSEELHQLVKSMLVVNPAE 266
                        250
                 ....*....|..
gi 755554055 396 RPSFRQTLMHLD 407
Cdd:cd13986  267 RPSIDDLLSRVH 278
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
164-411 6.22e-18

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 85.25  E-value: 6.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAvfLGKFRAEEVAIKKVREQnetDIKHLRKLK-HPNIIAFKGVCTQAPC--------YCIIMEY 234
Cdd:cd14036   13 FAFVYEAQDVGTGKEYA--LKRLLSNEEEKNKAIIQ---EINFMKKLSgHPNIVQFCSAASIGKEesdqgqaeYLLLTEL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CaHGQLYEVLR---AGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTK 309
Cdd:cd14036   88 C-KGQLVDFVKkveAPGPFSPDTVLKIFYQTCRAVQHMHKQSppIIHRDLKIENLLIGNQGQIKLCDFGSATTEAHYPDY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 310 MSFAG-------------TVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGvgsnSLHLPV 373
Cdd:cd14036  167 SWSAQkrslvedeitrntTPMYRTPEMIdlySNYPIGEKQDIWALGCILYLLCFRKHPFEDGAKLRIINA----KYTIPP 242
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 755554055 374 PSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL-DIASA 411
Cdd:cd14036  243 NDTQYTVFHDLIRSTLKVNPEERLSITEIVEQLqELAAA 281
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
160-356 7.81e-18

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 86.25  E-value: 7.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPfEEISELQWLGSGAQGAVfLGKFRAE---EVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTQAPC 227
Cdd:cd07877   13 WEVP-ERYQNLSPVGSGAYGSV-CAAFDTKtglRVAVKKLSRPFQSiihakrtyrELRLLKHMKHENVIGLLDVFTPARS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 Y-----CIIMEYCAHGQLYEVLRAgRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE 302
Cdd:cd07877   91 LeefndVYLVTHLMGADLNNIVKC-QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH 169
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 303 LSDKSTkmSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd07877  170 TDDEMT--GYVATRWYRAPEIMLNwMHYNQTVDIWSVGCIMAELLTGRTLFPGTD 222
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
181-352 8.37e-18

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 85.08  E-value: 8.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 181 VFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK----ITPRLLV 256
Cdd:cd08229   52 VALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKqkrlIPEKTVW 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPVSEKVDI 335
Cdd:cd08229  132 KYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAhSLVGTPYYMSPERIHENGYNFKSDI 211
                        170
                 ....*....|....*..
gi 755554055 336 WSFGVVLWELLTGEIPY 352
Cdd:cd08229  212 WSLGCLLYEMAALQSPF 228
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
170-405 8.37e-18

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 84.57  E-value: 8.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFlgKFRAEE---VAIKKVR-----EQ------NEtdIKHLRKLKH-PNIIAFKG--VCTQAPCYCIIM 232
Cdd:cd14131    6 LKQLGKGGSSKVY--KVLNPKkkiYALKRVDlegadEQtlqsykNE--IELLKKLKGsDRIIQLYDyeVTDEDDYLYMVM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EyCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPN-VLVthTDAVKISDFGTSKELSDKST- 308
Cdd:cd14131   82 E-CGEIDLATILkkKRPKPIDPNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANfLLV--KGRLKLIDFGIAKAIQNDTTs 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 --KMSFAGTVAWMAPEVIR-----NEP-----VSEKVDIWSFGVVLWELLTGEIPYKDVDS-----SAIIwgvgSNSLHL 371
Cdd:cd14131  159 ivRDSQVGTLNYMSPEAIKdtsasGEGkpkskIGRPSDVWSLGCILYQMVYGKTPFQHITNpiaklQAII----DPNHEI 234
                        250       260       270
                 ....*....|....*....|....*....|....
gi 755554055 372 PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14131  235 EFPDIPNPDLIDVMKRCLQRDPKKRPSIPELLNH 268
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
165-412 9.32e-18

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 84.54  E-value: 9.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVF------LGKFRAEEV----AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEY 234
Cdd:cd06619    1 QDIQYQEILGHGNGGTVYkayhllTRRILAVKVipldITVELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLyevlRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDkSTKMSFAG 314
Cdd:cd06619   81 MDGGSL----DVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVN-SIAKTYVG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDssaiiwgvGSNSLHLPV----------PSTCPDG---- 380
Cdd:cd06619  156 TNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ--------KNQGSLMPLqllqcivdedPPVLPVGqfse 227
                        250       260       270
                 ....*....|....*....|....*....|...
gi 755554055 381 -FKILMKQTWQSKPRNRPSFRQTLMHLDIASAD 412
Cdd:cd06619  228 kFVHFITQCMRKQPKERPAPENLMDHPFIVQYN 260
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
193-418 1.28e-17

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 85.46  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 193 IKKVREQNETDIK-HLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHL 271
Cdd:cd14176   52 IDKSKRDPTEEIEiLLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 272 HKIIHRDLKSPNVLVT----HTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 346
Cdd:cd14176  132 QGVVHRDLKPSNILYVdesgNPESIRICDFGFAKQLrAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTML 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 347 TGEIPYK---DVDSSAIIWGVGSNSLHLP--VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQ 418
Cdd:cd14176  212 TGYTPFAngpDDTPEEILARIGSGKFSLSggYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQ 288
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
164-346 1.33e-17

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 84.24  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELqwlGSGAQGAVF------LGKFraeeVAIKKVREQNETD------------IKHLRKLKHPNIIAFKGVCTQA 225
Cdd:cd07863    2 YEPVAEI---GVGAYGTVYkardphSGHF----VALKSVRVQTNEDglplstvrevalLKRLEAFDHPNIVRLMDVCATS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRAGRKITP------RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT 299
Cdd:cd07863   75 RTDRETKVTLVFEHVDQDLRTYLDKVPppglpaETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGL 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755554055 300 SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELL 346
Cdd:cd07863  155 ARIYSCQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 201
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
170-354 1.33e-17

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 85.05  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLG--KFRAEEVAIKKV-------------REqnetdIKHLRKLKHPNIIAFKGVcTQAPCYC----- 229
Cdd:cd07849   10 LSYIGEGAYGMVCSAvhKPTGQKVAIKKIspfehqtyclrtlRE-----IKILLRFKHENIIGILDI-QRPPTFEsfkdv 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 -IIMEYcAHGQLYEVLRagrkiTPRLLVD----WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK--- 301
Cdd:cd07849   84 yIVQEL-METDLYKLIK-----TQHLSNDhiqyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARiad 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 302 ELSDKSTKMS-FAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGE--IPYKD 354
Cdd:cd07849  158 PEHDHTGFLTeYVATRWYRAPEIMLNsKGYTKAIDIWSVGCILAEMLSNRplFPGKD 214
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
173-353 1.37e-17

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 84.85  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR-AEEV-AIKKVREQ---NETDI------KHLRKL--KHPNIIAFKGvCTQAPCYCI-IMEYCAHG 238
Cdd:cd05591    3 LGKGSFGKVMLAERKgTDEVyAIKVLKKDvilQDDDVdctmteKRILALaaKHPFLTALHS-CFQTKDRLFfVMEYVNGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QL-YEVLRAGRKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTV 316
Cdd:cd05591   82 DLmFQIQRARKFDEPRARF-YAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEgILNGKTTTTFCGTP 160
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd05591  161 DYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFE 197
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
165-357 1.37e-17

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 84.40  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFlgKFRAEE----VAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCII 231
Cdd:cd07846    1 EKYENLGLVGEGSYGMVM--KCRHKEtgqiVAIKKFLESEDDKmvkkiamreIKMLKQLRHENLVNLIEVFRRKKRWYLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL-SDKSTKM 310
Cdd:cd07846   79 FEFVDHTVLDDLEKYPNGLDESRVRKYLFQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLaAPGEVYT 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEK-VDIWSFGVVLWELLTGEiPYKDVDS 357
Cdd:cd07846  159 DYVATRWYRAPELLVGDTKYGKaVDVWAVGCLVTEMLTGE-PLFPGDS 205
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
173-352 1.54e-17

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 85.46  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE--VAIKKVREQ---NETDIKHLRKLKH--------PNIIAFKGvCTQAPCYC-IIMEYCAHG 238
Cdd:cd05617   23 IGRGSYAKVLLVRLKKNDqiYAMKVVKKElvhDDEDIDWVQTEKHvfeqassnPFLVGLHS-CFQTTSRLfLVIEYVNGG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVA 317
Cdd:cd05617  102 DLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEgLGPGDTTSTFCGTPN 181
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd05617  182 YIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPF 216
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
170-354 1.69e-17

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 84.77  E-value: 1.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLG--KFRAEEVAIKKVRE--QNETDIKH-------LRKLKHPNIIAFKGVCTQ-------APCYcII 231
Cdd:cd07850    5 LKPIGSGAQGIVCAAydTVTGQNVAIKKLSRpfQNVTHAKRayrelvlMKLVNHKNIIGLLNVFTPqksleefQDVY-LV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHgQLYEVLRagrkitprLLVDWSTgiasgMNYL---------HLHK--IIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd07850   84 MELMDA-NLCQVIQ--------MDLDHER-----MSYLlyqmlcgikHLHSagIIHRDLKPSNIVVKSDCTLKILDFGLA 149
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 301 KELSDkSTKMS-FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEI--PYKD 354
Cdd:cd07850  150 RTAGT-SFMMTpYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIRGTVlfPGTD 205
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
201-443 1.72e-17

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 84.13  E-value: 1.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 201 ETDIKHLrkLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL-YEVLR---AGRKITPRLLVDWSTGIASGMNYLHLHKIIH 276
Cdd:cd14094   55 EASICHM--LKHPHIVELLETYSSDGMLYMVFEFMDGADLcFEIVKradAGFVYSEAVASHYMRQILEALRYCHDNNIIH 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 277 RDLKSPNVLVTHTD---AVKISDFGTSKELSDKSTKMS-FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14094  133 RDVKPHCVLLASKEnsaPVKLGGFGVAIQLGESGLVAGgRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPF 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 353 KDvDSSAIIWGV--GSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLAtpqetYFKSQAEWRE 430
Cdd:cd14094  213 YG-TKERLFEGIikGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWIKERDRYA-----YRIHLPETVE 286
                        250
                 ....*....|...
gi 755554055 431 EVKKHFEKIKSEG 443
Cdd:cd14094  287 QLRKFNARRKLKG 299
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
160-356 1.78e-17

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 84.95  E-value: 1.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPfEEISELQWLGSGAQGAV--FLGKFRAEEVAIKKVREQNETDI---------KHLRKLKHPNIIAFKGVCTQAPCY 228
Cdd:cd07879   11 WELP-ERYTSLKQVGSGAYGSVcsAIDKRTGEKVAIKKLSRPFQSEIfakrayrelTLLKHMQHENVIGLLDVFTSAVSG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 ------CIIMEYcAHGQLYEVLraGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE 302
Cdd:cd07879   90 defqdfYLVMPY-MQTDLQKIM--GHPLSEDKVQYLVYQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARH 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 303 LSDKSTkmSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd07879  167 ADAEMT--GYVVTRWYRAPEVILNwMHYNQTVDIWSVGCIMAEMLTGKTLFKGKD 219
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
194-362 2.18e-17

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 83.56  E-value: 2.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 194 KKVREQNETDIKHLRKLKHPNIIAF----KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYL 269
Cdd:cd14030   65 KSERQRFKEEAGMLKGLQHPNIVRFydswESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFL 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 270 HLHK--IIHRDLKSPNVLVTH-TDAVKISDFGTSKeLSDKSTKMSFAGTVAWMAPEVIRnEPVSEKVDIWSFGVVLWELL 346
Cdd:cd14030  145 HTRTppIIHRDLKCDNIFITGpTGSVKIGDLGLAT-LKRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMA 222
                        170
                 ....*....|....*.
gi 755554055 347 TGEIPYKDVDSSAIIW 362
Cdd:cd14030  223 TSEYPYSECQNAAQIY 238
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
171-353 2.21e-17

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 84.19  E-value: 2.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGKFR------AEEVAIKKVREQN---ETDIKHLRKL----KHPNIIAFKgVCTQAPCYCI-IMEYCA 236
Cdd:cd05590    1 RVLGKGSFGKVMLARLKesgrlyAVKVLKKDVILQDddvECTMTEKRILslarNHPFLTQLY-CCFQTPDRLFfVMEFVN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGT 315
Cdd:cd05590   80 GGDLMFHIQKSRRFDEARARFYAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEgIFNGKTTSTFCGT 159
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd05590  160 PDYIAPEILQEMLYGPSVDWWAMGVLLYEMLCGHAPFE 197
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
262-405 2.22e-17

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 83.46  E-value: 2.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPVS---EKVDIWS 337
Cdd:cd14200  133 IVLGIEYLHYQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDALLsSTAGTPAFMAPETLSDSGQSfsgKALDVWA 212
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 338 FGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14200  213 MGVTLYCFVYGKCPFIDEFILALHNKIKNKPVEFPEEPEISEELKDLILKMLDKNPETRITVPEIKVH 280
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
213-352 2.30e-17

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 83.45  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 213 PNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR------KITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd14197   69 PWVINLHEVYETASEMILVLEYAAGGEIFNQCVADReeafkeKDVKRLMKQ----ILEGVSFLHNNNVVHLDLKPQNILL 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 287 THTDA---VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14197  145 TSESPlgdIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYEPISTATDMWSIGVLAYVMLTGISPF 213
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
171-405 2.36e-17

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 83.12  E-value: 2.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVF--LGKFRAEEVAIKKVRE----QNETDIkHLRKLKHPNII----AFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14172   10 QVLGLGVNGKVLecFHRRTGQKCALKLLYDspkaRREVEH-HWRASGGPHIVhildVYENMHHGKRCLLIIMECMEGGEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT--HTDAV-KISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd14172   89 FSRIqeRGDQAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLYTskEKDAVlKLTDFGFAKETTVQNALQTPCYT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWG------VGSNSLHLPVPSTCPDGFKILMKQTW 389
Cdd:cd14172  169 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGmkrrirMGQYGFPNPEWAEVSEEAKQLIRHLL 248
                        250
                 ....*....|....*.
gi 755554055 390 QSKPRNRPSFRQTLMH 405
Cdd:cd14172  249 KTDPTERMTITQFMNH 264
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
170-357 2.99e-17

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 83.99  E-value: 2.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAV----FLGKFRAEEVAIKKVRE--QNETDIKH-LRKLK-------HPNI-------IAFKGVCTQAPCY 228
Cdd:cd07857    5 IKELGQGAYGIVcsarNAETSEEETVAIKKITNvfSKKILAKRaLRELKllrhfrgHKNItclydmdIVFPGNFNELYLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 229 CIIMEYcahgQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKST 308
Cdd:cd07857   85 EELMEA----DLHQIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSENPG 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755554055 309 KMS-----FAGTVAWMAPEV-IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS 357
Cdd:cd07857  161 ENAgfmteYVATRWYRAPEImLSFQSYTKAIDVWSVGCILAELLGRKPVFKGKDY 215
PK_GC-C cd14044
Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain ...
184-401 3.07e-17

Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-C binds and is activated by the intestinal hormones, guanylin (GN) and uroguanylin (UGN), which are secreted after salty meals to inhibit sodium absorption and induce the secretion of chloride, bicarbonate, and water. GN and UGN are also present in the kidney, where they induce increased salt and water secretion. This prevents the development of hypernatremia and hypervolemia after ingestion of high amounts of salt. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-C subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270946 [Multi-domain]  Cd Length: 271  Bit Score: 83.01  E-value: 3.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAIKKVR-------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 256
Cdd:cd14044   27 GKYDKKVVILKDLKnnegnftEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLRDVLNDKISYPDGTFM 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWS------TGIASGMNYLHLHKI-IHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTkmsfagtvAWMAPEVIRNEPV 329
Cdd:cd14044  107 DWEfkisvmYDIAKGMSYLHSSKTeVHGRLKSTNCVVDSRMVVKITDFGCNSILPPSKD--------LWTAPEHLRQAGT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 330 SEKVDIWSFGVVLWE-LLTGEIPYKDV--DSSAIIWGVGSNSLHLPVPstcPDGF-----------KILMKQTWQSKPRN 395
Cdd:cd14044  179 SQKGDVYSYGIIAQEiILRKETFYTAAcsDRKEKIYRVQNPKGMKPFR---PDLNlesagererevYGLVKNCWEEDPEK 255

                 ....*.
gi 755554055 396 RPSFRQ 401
Cdd:cd14044  256 RPDFKK 261
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
175-357 4.28e-17

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 82.28  E-value: 4.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 175 SGAQGAVFLGKFraeevaIKKVREQNE--TDIKH----LRKLK-HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE--VLR 245
Cdd:cd14198   29 SKSTGQEYAAKF------LKKRRRGQDcrAEILHeiavLELAKsNPRVVNLHEVYETTSEIILILEYAAGGEIFNlcVPD 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKMSFAGTVAWMAPE 322
Cdd:cd14198  103 LAEMVSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSIYPlgdIKIVDFGMSRKIGHACELREIMGTPEYLAPE 182
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755554055 323 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS 357
Cdd:cd14198  183 ILNYDPITTATDMWNIGVIAYMLLTHESPFVGEDN 217
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
193-358 5.98e-17

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 83.24  E-value: 5.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 193 IKKVREQNETDI------KHLRKL--KHPNIIAFKGvCTQAPCYC-IIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIA 263
Cdd:cd05588   28 IKKELVNDDEDIdwvqteKHVFETasNHPFLVGLHS-CFQTESRLfFVIEFVNGGDLMFHMQRQRRLPEEHARFYSAEIS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 264 SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE-LSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 342
Cdd:cd05588  107 LALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEgLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLM 186
                        170
                 ....*....|....*.
gi 755554055 343 WELLTGEIPYKDVDSS 358
Cdd:cd05588  187 FEMLAGRSPFDIVGSS 202
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
173-353 6.05e-17

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 82.38  E-value: 6.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA----------EEVAIKKVREQ----NETDIkhLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd05630    8 LGKGGFGEVCACQVRAtgkmyackklEKKRIKKRKGEamalNEKQI--LEKVNSRFVVSLAYAYETKDALCLVLTLMNGG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QL----YEVLRAGRKiTPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAG 314
Cdd:cd05630   86 DLkfhiYHMGQAGFP-EARAVF-YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG 163
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 755554055 315 TVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:cd05630  164 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQ 202
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
165-346 6.57e-17

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 83.18  E-value: 6.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAV--FLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVC-TQAPC----- 227
Cdd:cd07855    5 DRYEPIETIGSGAYGVVcsAIDTKSGQKVAIKKIPNAFDVvttakrtlrELKILRHFKHDNIIAIRDILrPKVPYadfkd 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 -YCI--IMEycahGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS 304
Cdd:cd07855   85 vYVVldLME----SDLHHIIHSDQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLC 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 305 DKSTKMSFAGT--VA---WMAPEVIRNEP-VSEKVDIWSFGVVLWELL 346
Cdd:cd07855  161 TSPEEHKYFMTeyVAtrwYRAPELMLSLPeYTQAIDMWSVGCIFAEML 208
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
171-434 6.74e-17

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 82.39  E-value: 6.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVF--LGKFRAEEVAIKKVRE----QNETDIkHLRKLKHPNII----AFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14170    8 QVLGLGINGKVLqiFNKRTQEKFALKMLQDcpkaRREVEL-HWRASQCPHIVrivdVYENLYAGRKCLLIVMECLDGGEL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH---TDAVKISDFGTSKELSDKSTKMSFAGT 315
Cdd:cd14170   87 FSRIqdRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSkrpNAILKLTDFGFAKETTSHNSLTTPCYT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 316 VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWG------VGSNSLHLPVPSTCPDGFKILMKQTW 389
Cdd:cd14170  167 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGmktrirMGQYEFPNPEWSEVSEEVKMLIRNLL 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 390 QSKPRNRPSFRQTLMHLDIA-SADVLATPQET--YFKSQAEWREEVKK 434
Cdd:cd14170  247 KTEPTQRMTITEFMNHPWIMqSTKVPQTPLHTsrVLKEDKERWEDVKE 294
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
160-356 6.77e-17

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 83.08  E-value: 6.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 160 WEVPfEEISELQWLGSGAQGAV--FLGKFRAEEVAIKKVREQNETDI---------KHLRKLKHPNIIAFKGVCTQAPC- 227
Cdd:cd07880   11 WEVP-DRYRDLKQVGSGAYGTVcsALDRRTGAKVAIKKLYRPFQSELfakrayrelRLLKHMKHENVIGLLDVFTPDLSl 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 228 -----YCIIMEYCAH--GQLYEVLRAGRKITPRLLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS 300
Cdd:cd07880   90 drfhdFYLVMPFMGTdlGKLMKHEKLSEDRIQFLVYQ----MLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755554055 301 KELSDKSTkmSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd07880  166 RQTDSEMT--GYVVTRWYRAPEVILNwMHYTQTVDIWSVGCIMAEMLTGKPLFKGHD 220
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
207-352 8.54e-17

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 81.10  E-value: 8.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCaHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd14108   52 LAELDHKSIVRFHDAFEKRRVVIIVTELC-HEELLERITKRPTVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKPENLLM 130
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 287 --THTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14108  131 adQKTDQVRICDFGNAQELTPNEPQYCKYGTPEFVAPEIVNQSPVSKVTDIWPVGVIAYLCLTGISPF 198
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
262-353 9.28e-17

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 81.63  E-value: 9.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 341
Cdd:cd05605  111 ITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPEGETIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCL 190
                         90
                 ....*....|..
gi 755554055 342 LWELLTGEIPYK 353
Cdd:cd05605  191 IYEMIEGQAPFR 202
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
175-352 9.53e-17

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 81.56  E-value: 9.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 175 SGAQGAVFLGKFRAEEVA---IKKVREQNETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI 250
Cdd:cd14181   34 TGQEFAVKIIEVTAERLSpeqLEEVRSSTLKEIHILRQVSgHPSIITLIDSYESSTFIFLVFDLMRRGELFDYLTEKVTL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 251 TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIR----- 325
Cdd:cd14181  114 SEKETRSIMRSLLEAVSYLHANNIVHRDLKPENILLDDQLHIKLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKcsmde 193
                        170       180
                 ....*....|....*....|....*...
gi 755554055 326 -NEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14181  194 tHPGYGKEVDLWACGVILFTLLAGSPPF 221
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
173-414 1.38e-16

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 81.77  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCT----------QAPCYCII 231
Cdd:cd07864   15 IGEGTYGQVYKAkdKDTGELVALKKVRLDNEKEgfpitaireIKILRQLNHRSVVNLKEIVTdkqdaldfkkDKGAFYLV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCAHgQLYEVLRAGrkitprlLVDWSTG-IAS-------GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKeL 303
Cdd:cd07864   95 FEYMDH-DLMGLLESG-------LVHFSEDhIKSfmkqlleGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLAR-L 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 304 SDKSTKMSFAGTVA--WMAPE--VIRNEPVSEKVDIWSFGVVLWELLTGEiPYKDVDSSAIIWGVGSNSLHLPVPSTCPD 379
Cdd:cd07864  166 YNSEESRPYTNKVItlWYRPPelLLGEERYGPAIDVWSCGCILGELFTKK-PIFQANQELAQLELISRLCGSPCPAVWPD 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 380 GFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVL 414
Cdd:cd07864  245 VIKLPYFNTMKPKKQYRRRLREEFSFIPTPALDLL 279
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
152-356 1.61e-16

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 82.02  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 152 YKLQQQDT-WEVPfEEISELQWLGSGAQGAV---FLGKFRaEEVAIKKVREQNET---------DIKHLRKLKHPNIIAF 218
Cdd:cd07878    2 YRQELNKTvWEVP-ERYQNLTPVGSGAYGSVcsaYDTRLR-QKVAVKKLSRPFQSliharrtyrELRLLKHMKHENVIGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 219 KGVCTQAPCY-----CIIMEYCAHGQLYEVLRAgRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVK 293
Cdd:cd07878   80 LDVFTPATSIenfneVYLVTNLMGADLNNIVKC-QKLSDEHVQFLIYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELR 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 294 ISDFGTSKELSDKSTkmSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 356
Cdd:cd07878  159 ILDFGLARQADDEMT--GYVATRWYRAPEIMLNwMHYNQTVDIWSVGCIMAELLKGKALFPGND 220
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
164-348 1.75e-16

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 81.21  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNE-----TDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd07871    4 LETYVKLDKLGEGTYATVFKGRSKLTEnlVALKEIRLEHEegapcTAIREvslLKNLKHANIVTLHDIIHTERCLTLVFE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA 313
Cdd:cd07871   84 YLDSDLKQYLDNCGNLMSMHNVKIFMFQLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNE 163
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 314 GTVAWMAPE--VIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd07871  164 VVTLWYRPPdvLLGSTEYSTPIDMWGVGCILYEMATG 200
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
183-405 2.10e-16

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 80.00  E-value: 2.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 183 LGKFRAEEVAIK------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 256
Cdd:cd14115   13 LHKATRKDVAVKfvskkmKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILVLELMDDGRLLDYLMNHDELMEEKVA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 257 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVT---HTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 333
Cdd:cd14115   93 FYIRDIMEALQYLHNCRVAHLDIKPENLLIDlriPVPRVKLIDLEDAVQISGHRHVHHLLGNPEFAAPEVIQGTPVSLAT 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 334 DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP------VPSTCPDGFKILMkqtwQSKPRNRPSFRQTLMH 405
Cdd:cd14115  173 DIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPdeyfgdVSQAARDFINVIL----QEDPRRRPTAATCLQH 246
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
189-352 5.90e-16

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 80.04  E-value: 5.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 189 EEVAIKKV--REQNETDIKHLRKLK-HPNIIAFKGVCT-QAPCYcIIMEYCAHGQLYEVLRAGRKITP-------RLLVd 257
Cdd:cd14092   32 QEFAVKIVsrRLDTSREVQLLRLCQgHPNIVKLHEVFQdELHTY-LVMELLRGGELLERIRKKKRFTEseasrimRQLV- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 wstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV----S 330
Cdd:cd14092  110 ------SAVSFMHSKGVVHRDLKPENLLFTDEDddaEIKIVDFGFARLKPENQPLKTPCFTLPYAAPEVLKQALStqgyD 183
                        170       180
                 ....*....|....*....|..
gi 755554055 331 EKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14092  184 ESCDLWSLGVILYTMLSGQVPF 205
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
170-397 6.55e-16

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 79.91  E-value: 6.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVF---LGKFRAEeVAIKKVR----EQNETDIKHLRKL-----KHPNIIAF------------------- 218
Cdd:cd13977    5 IREVGRGSYGVVYeavVRRTGAR-VAVKKIRcnapENVELALREFWALssiqrQHPNVIQLeecvlqrdglaqrmshgss 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 219 -------------KGVCTQAPC--YCI--IMEYCAHGQLYEVLRAgRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKS 281
Cdd:cd13977   84 ksdlylllvetslKGERCFDPRsaCYLwfVMEFCDGGDMNEYLLS-RRPDRQTNTSFMLQLSSALAFLHRNQIVHRDLKP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 282 PNVLVTH---TDAVKISDFGTSKELS------------DKSTKMSFAGTVAWMAPEVIRNEpVSEKVDIWSFGVVLWELL 346
Cdd:cd13977  163 DNILISHkrgEPILKVADFGLSKVCSgsglnpeepanvNKHFLSSACGSDFYMAPEVWEGH-YTAKADIFALGIIIWAMV 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 347 TgEIPYKDVDSSAIIWG-----------VGSN-------SLHLPVP--STCPDGFKILMKQTWQSKPRNRP 397
Cdd:cd13977  242 E-RITFRDGETKKELLGtyiqqgkeivpLGEAllenpklELQIPLKkkKSMNDDMKQLLRDMLAANPQERP 311
STKc_BMPR1b cd14219
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs ...
165-354 6.85e-16

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1b, also called Activin receptor-Like Kinase 6 (ALK6), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Mutations in BMPR1b that led to inhibition of chondrogenesis can cause Brachydactyly (BD) type A2, a dominant hand malformation characterized by shortening and lateral deviation of the index fingers. A point mutation in the BMPR1b kinase domain is also associated with the Booroola phenotype, characterized by precocious differentiation of ovarian follicles. BMPR1b belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1b, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271121 [Multi-domain]  Cd Length: 305  Bit Score: 79.71  E-value: 6.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRAEEVAIK---KVREQN---ETDIKHLRKLKHPNIIAF-----KGVCTQAPCYcIIME 233
Cdd:cd14219    5 KQIQMVKQIGKGRYGEVWMGKWRGEKVAVKvffTTEEASwfrETEIYQTVLMRHENILGFiaadiKGTGSWTQLY-LITD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAgRKITPRLLVDWSTGIASGMNYLHLH--------KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD 305
Cdd:cd14219   84 YHENGSLYDYLKS-TTLDTKAMLKLAYSSVSGLCHLHTEifstqgkpAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIS 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSF-----AGTVAWMAPEVI-----RNEPVSE-KVDIWSFGVVLWEL----LTG------EIPYKD 354
Cdd:cd14219  163 DTNEVDIppntrVGTKRYMPPEVLdeslnRNHFQSYiMADMYSFGLILWEVarrcVSGgiveeyQLPYHD 232
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
144-352 6.96e-16

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 80.02  E-value: 6.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 144 IGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEE---VAIK-----KVREQNETD-----IKHLRKL 210
Cdd:PTZ00426   9 LHKKKDSDSTKEPKRKNKMKYEDFNFIRTLGTGSFGRVILATYKNEDfppVAIKrfeksKIIKQKQVDhvfseRKILNYI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 211 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTD 290
Cdd:PTZ00426  89 NHPFCVNLYGSFKDESYLYLVLEFVIGGEFFTFLRRNKRFPNDVGCFYAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDG 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755554055 291 AVKISDFGTSKELSDKStkMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:PTZ00426 169 FIKMTDFGFAKVVDTRT--YTLCGTPEYIAPEILLNVGHGKAADWWTLGIFIYEILVGCPPF 228
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
173-405 7.84e-16

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 78.87  E-value: 7.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHgQLY 241
Cdd:cd07835    7 IGEGTYGVVYKARDKLtgEIVALKKIRLETEDEgvpstaireISLLKELNHPNIVRLLDVVHSENKLYLVFEFLDL-DLK 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRK--ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKelsdkstkmSFA------ 313
Cdd:cd07835   86 KYMDSSPLtgLDPPLIKSYLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGALKLADFGLAR---------AFGvpvrty 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 314 ----GTVAWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTGEiPYKDVDS---------------SAIIW-GVGS------ 366
Cdd:cd07835  157 thevVTLWYRAPEILLGSKhYSTPVDIWSVGCIFAEMVTRR-PLFPGDSeidqlfrifrtlgtpDEDVWpGVTSlpdykp 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 367 -------NSLHLPVPSTCPDGFKILMkQTWQSKPRNRPSFRQTLMH 405
Cdd:cd07835  236 tfpkwarQDLSKVVPSLDEDGLDLLS-QMLVYDPAKRISAKAALQH 280
PTKc_Aatyk2 cd05086
Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs ...
170-361 8.92e-16

Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Aatyk2 is a member of the Aatyk subfamily of proteins, which are receptor kinases containing a transmembrane segment and a long C-terminal cytoplasmic tail with a catalytic domain. Aatyk2 is also called lemur tyrosine kinase 2 (Lmtk2) or brain-enriched kinase (Brek). It is expressed at high levels in early postnatal brain, and has been shown to play a role in nerve growth factor (NGF) signaling. Studies with knockout mice reveal that Aatyk2 is essential for late stage spermatogenesis. Although it is classified as a PTK based on sequence similarity and the phylogenetic tree, Aatyk2 has been functionally characterized as a serine/threonine kinase. The Aatyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270669 [Multi-domain]  Cd Length: 271  Bit Score: 78.75  E-value: 8.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGK-FRAEEVAIKKVRE--------QNETDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd05086    2 IQEIGNGWFGKVLLGEiYTGTSVARVVVKElkasanpkEQDDFLQQgepYYILQHPNILQCVGQCVEAIPYLLVFEFCDL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQLYEVLRAGRKITPR-----LLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS----KELSDKST 308
Cdd:cd05086   82 GDLKTYLANQQEKLRGdsqimLLQRMACEIAAGLAHMHKHNFLHSDLALRNCYLTSDLTVKVGDYGIGfsryKEDYIETD 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 309 KMSFAgTVAWMAPEVI--RNEPV-----SEKVDIWSFGVVLWELL-TGEIPYKDVDSSAII 361
Cdd:cd05086  162 DKKYA-PLRWTAPELVtsFQDGLlaaeqTKYSNIWSLGVTLWELFeNAAQPYSDLSDREVL 221
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
173-347 9.33e-16

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 78.70  E-value: 9.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVC-TQAPCYcIIMEYcahgqL 240
Cdd:cd07860    8 IGEGTYGVVYKARNKltGEVVALKKIRLDTETEgvpstaireISLLKELNHPNIVKLLDVIhTENKLY-LVFEF-----L 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGRKITPR------LLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAG 314
Cdd:cd07860   82 HQDLKKFMDASALtgiplpLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 161
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755554055 315 TVAWM-APEVIRN-EPVSEKVDIWSFGVVLWELLT 347
Cdd:cd07860  162 VTLWYrAPEILLGcKYYSTAVDIWSLGCIFAEMVT 196
pknD PRK13184
serine/threonine-protein kinase PknD;
173-353 1.09e-15

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 82.13  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVREqNETDIKHLRK-----------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ 239
Cdd:PRK13184  10 IGKGGMGEVYLAydPVCSRRVALKKIRE-DLSENPLLKKrflreakiaadLIHPGIVPVYSICSDGDPVYYTMPYIEGYT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRK---ITPRLLVDWSTG--------IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK------- 301
Cdd:PRK13184  89 LKSLLKSVWQkesLSKELAEKTSVGaflsifhkICATIEYVHSKGVLHRDLKPDNILLGLFGEVVILDWGAAIfkkleee 168
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755554055 302 ELSDKS-----------TKMS-FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK 353
Cdd:PRK13184 169 DLLDIDvdernicyssmTIPGkIVGTPDYMAPERLLGVPASESTDIYALGVILYQMLTLSFPYR 232
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
173-354 2.19e-15

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 78.57  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRA--EEVAIKKVRE--QNETD-------IKHLRKLKHPNIIAFKGVCTqAPC-------YciIMEY 234
Cdd:cd07858   13 IGRGAYGIVCSAKNSEtnEKVAIKKIANafDNRIDakrtlreIKLLRHLDHENVIAIKDIMP-PPHreafndvY--IVYE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 235 CAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS-FA 313
Cdd:cd07858   90 LMDTDLHQIIRSSQTLSDDHCQYFLYQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSEKGDFMTeYV 169
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755554055 314 GTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGE--IPYKD 354
Cdd:cd07858  170 VTRWYRAPELLLNcSEYTTAIDVWSVGCIFAELLGRKplFPGKD 213
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
258-353 2.60e-15

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 77.34  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS 337
Cdd:cd05631  107 YAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLAVQIPEGETVRGRVGTVGYMAPEVINNEKYTFSPDWWG 186
                         90
                 ....*....|....*.
gi 755554055 338 FGVVLWELLTGEIPYK 353
Cdd:cd05631  187 LGCLIYEMIQGQSPFR 202
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
153-363 3.39e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 3.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 153 KLQQQD-TWEVPF---------------EEISELQWLGSGAQGAVFLGKFRAEEV--AIKKVREQN---ETDIKHLRKLK 211
Cdd:PLN00113 662 RVENEDgTWELQFfdskvsksitindilSSLKEENVISRGKKGASYKGKSIKNGMqfVVKEINDVNsipSSEIADMGKLQ 741
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 212 HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-----GRKItprllvdwSTGIASGMNYLHLHKiihrdlkSPNVLV 286
Cdd:PLN00113 742 HPNIVKLIGLCRSEKGAYLIHEYIEGKNLSEVLRNlswerRRKI--------AIGIAKALRFLHCRC-------SPAVVV 806
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 287 THTDAVKISDFGTSKE---LSDKS---TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYK---DVDS 357
Cdd:PLN00113 807 GNLSPEKIIIDGKDEPhlrLSLPGllcTDTKCFISSAYVAPETRETKDITEKSDIYGFGLILIELLTGKSPADaefGVHG 886

                 ....*.
gi 755554055 358 SAIIWG 363
Cdd:PLN00113 887 SIVEWA 892
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
176-405 3.61e-15

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 76.59  E-value: 3.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLgkfrAEEVAIKK--------VREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAG 247
Cdd:cd13995   15 GAFGKVYL----AQDTKTKKrmacklipVEQFKPSDVEIQACFRHENIAELYGALLWEETVHLFMEAGEGGSVLEKLESC 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 248 RKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKIsDFGTSKELS-DKSTKMSFAGTVAWMAPEVIRN 326
Cdd:cd13995   91 GPMREFEIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVFMSTKAVLV-DFGLSVQMTeDVYVPKDLRGTEIYMSPEVILC 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 327 EPVSEKVDIWSFGVVLWELLTGEIP----YKDVDSSAIIWGVGSNSLHLP-VPSTCPDGFKILMKQTWQSKPRNRPSFRQ 401
Cdd:cd13995  170 RGHNTKADIYSLGATIIHMQTGSPPwvrrYPRSAYPSYLYIIHKQAPPLEdIAQDCSPAMRELLEAALERNPNHRSSAAE 249

                 ....
gi 755554055 402 TLMH 405
Cdd:cd13995  250 LLKH 253
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
173-405 3.83e-15

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 76.69  E-value: 3.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEE---VAIKKV---------REQNETDIKHLRKLK---HPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd14052    8 IGSGEFSQVYKVSERVPTgkvYAVKKLkpnyagakdRLRRLEEVSILRELTldgHDNIVQLIDSWEYHGHLYIQTELCEN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 GQL----YEVLRAGRKITPRL---LVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTkM 310
Cdd:cd14052   88 GSLdvflSELGLLGRLDEFRVwkiLVE----LSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGMATVWPLIRG-I 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 311 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG-EIP-------------YKDVD--SSAIIWGVGSNSLHLP-- 372
Cdd:cd14052  163 EREGDREYIAPEILSEHMYDKPADIFSLGLILLEAAANvVLPdngdawqklrsgdLSDAPrlSSTDLHSASSPSSNPPpd 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 755554055 373 --VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14052  243 ppNMPILSGSLDRVVRWMLSPEPDRRPTADDVLAT 277
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
173-405 5.80e-15

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 75.81  E-value: 5.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFlgKFRAEE----VAIKKVREQNETDIKHLRKLK----------HPNIIAFKGVCTQAPCYCIIMEYCAhG 238
Cdd:cd14050    9 LGEGSFGEVF--KVRSREdgklYAVKRSRSRFRGEKDRKRKLEeverheklgeHPNCVRFIKAWEEKGILYIQTELCD-T 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVLRAGRKITPR----LLVDwstgIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAG 314
Cdd:cd14050   86 SLQQYCEETHSLPESevwnILLD----LLKGLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGLVVELDKEDIHDAQEG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 315 TVAWMAPEVIRNEPvSEKVDIWSFGVVLWELLTgeipYKDVDSSAIIWGVGSNSlHLPVPST--CPDGFKILMKQTWQSK 392
Cdd:cd14050  162 DPRYMAPELLQGSF-TKAADIFSLGITILELAC----NLELPSGGDGWHQLRQG-YLPEEFTagLSPELRSIIKLMMDPD 235
                        250
                 ....*....|...
gi 755554055 393 PRNRPSFRQTLMH 405
Cdd:cd14050  236 PERRPTAEDLLAL 248
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
183-358 6.89e-15

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 76.62  E-value: 6.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 183 LGKFRAEEVAIKKVREQNETDI-KHLRKLK----HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVD 257
Cdd:cd14179   27 LHKKTNQEYAVKIVSKRMEANTqREIAALKlcegHPNIVKLHEVYHDQLHTFLVMELLKGGELLERIKKKQHFSETEASH 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVT---HTDAVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV 333
Cdd:cd14179  107 IMRKLVSAVSHMHDVGVVHRDLKPENLLFTdesDNSEIKIIDFGFARlKPPDNQPLKTPCFTLHYAAPELLNYNGYDESC 186
                        170       180
                 ....*....|....*....|....*
gi 755554055 334 DIWSFGVVLWELLTGEIPYKDVDSS 358
Cdd:cd14179  187 DLWSLGVILYTMLSGQVPFQCHDKS 211
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
270-387 7.28e-15

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 77.32  E-value: 7.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 270 HLHKI--IHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA------------------------------GTVA 317
Cdd:cd05573  116 SLHKLgfIHRDIKPDNILLDADGHIKLADFGLCTKMNKSGDRESYLndsvntlfqdnvlarrrphkqrrvraysavGTPD 195
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755554055 318 WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDvDSSAIIWGVGSN---SLHLPVPSTCPDGFKILMKQ 387
Cdd:cd05573  196 YIAPEVLRGTGYGPECDWWSLGVILYEMLYGFPPFYS-DSLVETYSKIMNwkeSLVFPDDPDVSPEAIDLIRR 267
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
166-403 7.29e-15

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 76.01  E-value: 7.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISELQWLGSGAQGAVF--LGKFRAEEVAIKK--VREQNETD-IKHLRKLK------HPNIIAFKGVC---TQAPCYcII 231
Cdd:cd14049    7 EFEEIARLGKGGYGKVYkvRNKLDGQYYAIKKilIKKVTKRDcMKVLREVKvlaglqHPNIVGYHTAWmehVQLMLY-IQ 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYCaHGQLYEVLrAGRKITPR-----------LLVDWSTGI----ASGMNYLHLHKIIHRDLKSPNVLVTHTD-AVKIS 295
Cdd:cd14049   86 MQLC-ELSLWDWI-VERNKRPCeeefksapytpVDVDVTTKIlqqlLEGVTYIHSMGIVHRDLKPRNIFLHGSDiHVRIG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 296 DFG-------------TSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLtgeIPY-KDVDSSAII 361
Cdd:cd14049  164 DFGlacpdilqdgndsTTMSRLNGLTHTSGVGTCLYAAPEQLEGSHYDFKSDMYSIGVILLELF---QPFgTEMERAEVL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 755554055 362 WGVGSNSLHLPVPSTCPDGFKILMKQTwQSKPRNRPSFRQTL 403
Cdd:cd14049  241 TQLRNGQIPKSLCKRWPVQAKYIKLLT-STEPSERPSASQLL 281
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
173-408 1.05e-14

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 77.19  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL----GKFRAEEVAIKKVR--EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHgQLYEVLRA 246
Cdd:PHA03207 100 LTPGSEGEVFVctkhGDEQRKKVIVKAVTggKTPGREIDILKTISHRAIINLIHAYRWKSTVCMVMPKYKC-DLFTYVDR 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 247 GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS---DKSTKMSFAGTVAWMAPEV 323
Cdd:PHA03207 179 SGPLPLEQAITIQRRLLEALAYLHGRGIIHRDVKTENIFLDEPENAVLGDFGAACKLDahpDTPQCYGWSGTLETNSPEL 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 324 IRNEPVSEKVDIWSFGVVLWELLTGEIPY--KDVDSS-----AIIWGVGSNSLHLPVPSTCPdgfkiLMKQTWQSKPRNR 396
Cdd:PHA03207 259 LALDPYCAKTDIWSAGLVLFEMSVKNVTLfgKQVKSSssqlrSIIRCMQVHPLEFPQNGSTN-----LCKHFKQYAIVLR 333
                        250
                 ....*....|....*...
gi 755554055 397 PSF------RQTLMHLDI 408
Cdd:PHA03207 334 PPYtippviRKYGMHMDV 351
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
165-361 1.08e-14

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 76.46  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGK--FRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFKGVCTqAPCYCIIME 233
Cdd:cd07856   10 TRYSDLQPVGMGAFGLVCSARdqLTGQNVAVKKIMKPFSTpvlakrtyrELKLLKHLRHENIISLSDIFI-SPLEDIYFV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTkmSFA 313
Cdd:cd07856   89 TELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLARIQDPQMT--GYV 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755554055 314 GTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGE--IPYKD-VDSSAII 361
Cdd:cd07856  167 STRYYRAPEIMLTwQKYDVEVDIWSAGCIFAEMLEGKplFPGKDhVNQFSII 218
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
164-348 1.20e-14

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 75.81  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd07873    1 LETYIKLDKLGEGTYATVYKGRSKLTDnlVALKEIRLEHEEgapctairEVSLLKDLKHANIVTLHDIIHTEKSLTLVFE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA 313
Cdd:cd07873   81 YLDKDLKQYLDDCGNSINMHNVKLFLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 160
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 314 GTVAWMAPE--VIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd07873  161 VVTLWYRPPdiLLGSTDYSTQIDMWGVGCIFYEMSTG 197
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
152-399 1.81e-14

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 76.22  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 152 YKLQQQDTWEVPFEEISELQWLGSGAQGAV--FLGKFRAEEVAIKKVRE--QNETDIKH-------LRKLKHPNIIAFKG 220
Cdd:cd07876    8 YSVQVADSTFTVLKRYQQLKPIGSGAQGIVcaAFDTVLGINVAVKKLSRpfQNQTHAKRayrelvlLKCVNHKNIISLLN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 221 VCTQAPCyciIMEYCAHGQLYEVLRAGRKITPRLLVDWST------GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKI 294
Cdd:cd07876   88 VFTPQKS---LEEFQDVYLVMELMDANLCQVIHMELDHERmsyllyQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 295 SDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLH 370
Cdd:cd07876  165 LDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHidqwNKVIEQLGTPSAE 244
                        250       260
                 ....*....|....*....|....*....
gi 755554055 371 lpvpstcpdgFKILMKQTWQSKPRNRPSF 399
Cdd:cd07876  245 ----------FMNRLQPTVRNYVENRPQY 263
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
194-354 1.83e-14

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 74.68  E-value: 1.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 194 KKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK 273
Cdd:cd14088   40 RKVRKAAKNEINILKMVKHPNILQLVDVFETRKEYFIFLELATGREVFDWILDQGYYSERDTSNVIRQVLEAVAYLHSLK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 274 IIHRDLKSPNVL----VTHTDAVkISDFGTSKeLSDKSTKMSfAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE 349
Cdd:cd14088  120 IVHRNLKLENLVyynrLKNSKIV-ISDFHLAK-LENGLIKEP-CGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGN 196

                 ....*
gi 755554055 350 IPYKD 354
Cdd:cd14088  197 PPFYD 201
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
173-352 2.33e-14

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 74.51  E-value: 2.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAV-----------FLGKFraeeVAIKKVREQ-NETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQL 240
Cdd:cd14104    8 LGRGQFGIVhrcvetsskktYMAKF----VKVKGADQVlVKKEISILNIARHRNILRLHESFESHEELVMIFEFISGVDI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 241 YEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL-VTH-TDAVKISDFGTSKELS-DKSTKMSFAgTV 316
Cdd:cd14104   84 FERITTARfELNEREIVSYVRQVCEALEFLHSKNIGHFDIRPENIIyCTRrGSYIKIIEFGQSRQLKpGDKFRLQYT-SA 162
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14104  163 EFYAPEVHQHESVSTATDMWSLGCLVYVLLSGINPF 198
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
166-352 2.60e-14

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 74.09  E-value: 2.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 166 EISElQWLGSGAQGAVFLGKFRAE----EVAIKKVRE--QNETDIkhLRKLKHPNIIAF-KGVCTQAPCYCIIMEYCAHG 238
Cdd:cd14109    6 EIGE-EDEKRAAQGAPFHVTERSTgrnfLAQLRYGDPflMREVDI--HNSLDHPNIVQMhDAYDDEKLAVTVIDNLASTI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYE--VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKsPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTV 316
Cdd:cd14109   83 ELVRdnLLPGKDYYTERQVAVFVRQLLLALKHMHDLGIAHLDLR-PEDILLQDDKLKLADFGQSRRLLRGKLTTLIYGSP 161
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14109  162 EFVSPEIVNSYPVTLATDMWSVGVLTYVLLGGISPF 197
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
158-403 2.64e-14

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 77.47  E-value: 2.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  158 DTWEVPFEEISELQWLGSGAQGAVFLGKF-RAEE------VAIKKVREQNET----DIKHLRKLKHPNIIAF--KGVCTQ 224
Cdd:PTZ00266    6 DDGESRLNEYEVIKKIGNGRFGEVFLVKHkRTQEffcwkaISYRGLKEREKSqlviEVNVMRELKHKNIVRYidRFLNKA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  225 APCYCIIMEYCAHGQL----YEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK-------IIHRDLKSPNVLVT----HT 289
Cdd:PTZ00266   86 NQKLYILMEFCDAGDLsrniQKCYKMFGKIEEHAIVDITRQLLHALAYCHNLKdgpngerVLHRDLKPQNIFLStgirHI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055  290 DAV-------------KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVS--EKVDIWSFGVVLWELLTGEIPYKD 354
Cdd:PTZ00266  166 GKItaqannlngrpiaKIGDFGLSKNIGIESMAHSCVGTPYYWSPELLLHETKSydDKSDMWALGCIIYELCSGKTPFHK 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 755554055  355 VDSSAIIWGVGSNSLHLPVPSTCPDgFKILMKQTWQSKPRNRPSFRQTL 403
Cdd:PTZ00266  246 ANNFSQLISELKRGPDLPIKGKSKE-LNILIKNLLNLSAKERPSALQCL 293
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
173-352 3.45e-14

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 74.30  E-value: 3.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGA----QGAVFL--GKFRAEEVAIKKV---REQNETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE 242
Cdd:cd14174   10 LGEGAyakvQGCVSLqnGKEYAVKIIEKNAghsRSRVFREVETLYQCQgNKNILELIEFFEDDTRFYLVFEKLRGGSILA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 243 VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDF--GTSKELSDKSTKMSF----- 312
Cdd:cd14174   90 HIQKRKHFNEREASRVVRDIASALDFLHTKGIAHRDLKPENILCESPDKvspVKICDFdlGSGVKLNSACTPITTpeltt 169
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 755554055 313 -AGTVAWMAPEVIR--NEPVS---EKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14174  170 pCGSAEYMAPEVVEvfTDEATfydKRCDLWSLGVILYIMLSGYPPF 215
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
173-352 5.37e-14

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 73.31  E-value: 5.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFlgkfRAEEV------AIKKVREQ--NETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL 244
Cdd:cd13991   14 IGRGSFGEVH----RMEDKqtgfqcAVKKVRLEvfRAEELMACAGLTSPRVVPLYGAVREGPWVNIFMDLKEGGSLGQLI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH--TDAVkISDFGTSKELSDKSTKMS------FAGTV 316
Cdd:cd13991   90 KEQGCLPEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSdgSDAF-LCDFGHAECLDPDGLGKSlftgdyIPGTE 168
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 755554055 317 AWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd13991  169 THMAPEVVLGKPCDAKVDVWSSCCMMLHMLNGCHPW 204
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
169-348 6.17e-14

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 73.28  E-value: 6.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFR--AEEVAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG 238
Cdd:cd07836    4 QLEKLGEGTYATVYKGRNRttGEIVALKEIHLDAEEgtpstairEISLMKELKHENIVRLHDVIHTENKLMLVFEYMDKD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 -QLYEVLRAGRK-ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTV 316
Cdd:cd07836   84 lKKYMDTHGVRGaLDPNTVKSFTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFSNEVVT 163
                        170       180       190
                 ....*....|....*....|....*....|....
gi 755554055 317 AWM-APEVIRNEPV-SEKVDIWSFGVVLWELLTG 348
Cdd:cd07836  164 LWYrAPDVLLGSRTySTSIDIWSVGCIMAEMITG 197
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
266-352 6.60e-14

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 74.14  E-value: 6.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 266 MNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRNEP-VSEKVDIWSFGVVLW 343
Cdd:cd05586  109 LEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKaDLTDNKTTNTFCGTTEYLAPEVLLDEKgYTKMVDFWSLGVLVF 188

                 ....*....
gi 755554055 344 ELLTGEIPY 352
Cdd:cd05586  189 EMCCGWSPF 197
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
173-347 7.61e-14

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 73.07  E-value: 7.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQ--------NETDIKHLRKLK-HPNIIAFKGVCTQAP--CYCIIMEYcAHGQ 239
Cdd:cd07831    7 IGEGTFSEVLKAQSRktGKYYAIKCMKKHfksleqvnNLREIQALRRLSpHPNILRLIEVLFDRKtgRLALVFEL-MDMN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVLRAGRKITPRLLV-DWSTGIASGMNYLHLHKIIHRDLKSPNVLVtHTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd07831   86 LYELIKGRKRPLPEKRVkNYMYQLLKSLDHMHRNGIFHRDIKPENILI-KDDILKLADFGSCRGIYSKPPYTEYISTRWY 164
                        170       180       190
                 ....*....|....*....|....*....|
gi 755554055 319 MAPEVIRNEPV-SEKVDIWSFGVVLWELLT 347
Cdd:cd07831  165 RAPECLLTDGYyGPKMDIWAVGCVFFEILS 194
PK_IRAK3 cd14160
Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain ...
173-348 7.77e-14

Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK3 (or IRAK-M) is the only IRAK that does not show kinase activity. It is found only in monocytes and macrophages in humans, and functions as a negative regulator of TLR signaling including TLR-2 induced p38 activation. It also negatively regulates the alternative NFkB pathway in a TLR-2 specific manner. IRAK3 is downregulated in the monocytes of obese people, and is associated with high SOD2, a marker of mitochondrial oxidative stress. It is an important inhibitor of inflammation in association with obesity and metabolic syndrome. The IRAK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271062 [Multi-domain]  Cd Length: 276  Bit Score: 72.99  E-value: 7.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRK-----------LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd14160    1 IGEGEIFEVYRVRIGNRSYAVKLFKQEKKMQWKKHWKrflselevlllFQHPNILELAAYFTETEKFCLVYPYMQNGTLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 242 EVLRAGRKITPrllVDWST------GIASGMNYLHLHK---IIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTK 309
Cdd:cd14160   81 DRLQCHGVTKP---LSWHEriniliGIAKAIHYLHNSQpctVICGNISSANILLDDQMQPKLTDFALAHfrpHLEDQSCT 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 755554055 310 MSFAGT----VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd14160  158 INMTTAlhkhLWYMPEEYIRQGKLSVKTDVYSFGIVIMEVLTG 200
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
184-353 9.98e-14

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 72.98  E-value: 9.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAIKKVREQNETDIKHLRKLK-HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGI 262
Cdd:cd14180   31 GQEYAVKIISRRMEANTQREVAALRLCQsHPNIVALHEVLHDQYHTYLVMELLRGGELLDRIKKKARFSESEASQLMRSL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 263 ASGMNYLHLHKIIHRDLKSPNVLV---THTDAVKISDFGTSKELSDKSTKMSFAG-TVAWMAPEVIRNEPVSEKVDIWSF 338
Cdd:cd14180  111 VSAVSFMHEAGVVHRDLKPENILYadeSDGAVLKVIDFGFARLRPQGSRPLQTPCfTLQYAAPELFSNQGYDESCDLWSL 190
                        170
                 ....*....|....*
gi 755554055 339 GVVLWELLTGEIPYK 353
Cdd:cd14180  191 GVILYTMLSGQVPFQ 205
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
165-354 1.31e-13

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 73.37  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLG--KFRAEEVAIKKVR----------EQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIM 232
Cdd:cd05610    4 EEFVIVKPISRGAFGKVYLGrkKNNSKLYAVKVVKkadminknmvHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 233 EYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-------ELSD 305
Cdd:cd05610   84 EYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKvtlnrelNMMD 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 306 KSTKMSFA-----------------------------------------------GTVAWMAPEVIRNEPVSEKVDIWSF 338
Cdd:cd05610  164 ILTTPSMAkpkndysrtpgqvlslisslgfntptpyrtpksvrrgaarvegerilGTPDYLAPELLLGKPHGPAVDWWAL 243
                        250
                 ....*....|....*.
gi 755554055 339 GVVLWELLTGEIPYKD 354
Cdd:cd05610  244 GVCLFEFLTGIPPFND 259
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
170-419 1.32e-13

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 72.30  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLG--KFRAEEVAIKKVREQNE-----TDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYcAHGQ 239
Cdd:cd07870    5 LEKLGEGSYATVYKGisRINGQLVALKVISMKTEegvpfTAIREaslLKGLKHANIVLLHDIIHTKETLTFVFEY-MHTD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 L--YEVLRAGrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA 317
Cdd:cd07870   84 LaqYMIQHPG-GLHPYNVRLFMFQLLRGLAYIHGQHILHRDLKPQNLLISYLGELKLADFGLARAKSIPSQTYSSEVVTL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 318 WMAPE--VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS----AIIWGVgsnsLHLPVPSTCPDGFKIL-MKQTWQ 390
Cdd:cd07870  163 WYRPPdvLLGATDYSSALDIWGAGCIFIEMLQGQPAFPGVSDVfeqlEKIWTV----LGVPTEDTWPGVSKLPnYKPEWF 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 755554055 391 sKPRNRPSFRQTLMHL-------DIASADVLATPQE 419
Cdd:cd07870  239 -LPCKPQQLRVVWKRLsrppkaeDLASQMLMMFPKD 273
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
262-352 1.61e-13

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 72.37  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTD---AVKISDF--GTSKELSDKSTKMSF------AGTVAWMAPEVIR--NEP 328
Cdd:cd14173  109 IASALDFLHNKGIAHRDLKPENILCEHPNqvsPVKICDFdlGSGIKLNSDCSPISTpelltpCGSAEYMAPEVVEafNEE 188
                         90       100
                 ....*....|....*....|....*..
gi 755554055 329 VS---EKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14173  189 ASiydKRCDLWSLGVILYIMLSGYPPF 215
STKc_IRAK2 cd14157
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 2; ...
212-348 1.66e-13

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK2 plays a role in mediating NFkB activation by TLR3, TLR4, and TLR8. It is specifically targeted by the viral protein A52, which is important for virulence, to inhibit all IL-1/TLR pathways, indicating that IRAK2 has a predominant role in NFkB activation. It is redundant with IRAK1 in early signaling but is critical for late and sustained activation. The IRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271059 [Multi-domain]  Cd Length: 289  Bit Score: 72.18  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 212 HPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLR--AGRKITP---RLLVdwSTGIASGMNYLHLHKIIHRDLKSPNVLV 286
Cdd:cd14157   51 HPNILPLLGFCVESDCHCLIYPYMPNGSLQDRLQqqGGSHPLPweqRLSI--SLGLLKAVQHLHNFGILHGNIKSSNVLL 128
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755554055 287 THTDAVKISDFGTSKELSDKSTKMSFAGT------VAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd14157  129 DGNLLPKLGHSGLRLCPVDKKSVYTMMKTkvlqisLAYLPEDFVRHGQLTEKVDIFSCGVVLAEILTG 196
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
173-355 2.08e-13

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 72.51  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFR--AEEVAIKKVREQNE---------TDIKHLRKLKHPNIIAFKGVC------TQAPCYCI--IME 233
Cdd:cd07859    8 IGKGSYGVVCSAIDThtGEKVAIKKINDVFEhvsdatrilREIKLLRLLRHPDIVEIKHIMlppsrrEFKDIYVVfeLME 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 ycahGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-ELSDKSTKMSF 312
Cdd:cd07859   88 ----SDLHQVIKANDDLTPEHHQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARvAFNDTPTAIFW 163
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 755554055 313 AGTVA---WMAPEVIRN--EPVSEKVDIWSFGVVLWELLTGE--IPYKDV 355
Cdd:cd07859  164 TDYVAtrwYRAPELCGSffSKYTPAIDIWSIGCIFAEVLTGKplFPGKNV 213
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
258-353 2.21e-13

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 72.31  E-value: 2.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS 337
Cdd:cd05632  109 YAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGESIRGRVGTVGYMAPEVLNNQRYTLSPDYWG 188
                         90
                 ....*....|....*.
gi 755554055 338 FGVVLWELLTGEIPYK 353
Cdd:cd05632  189 LGCLIYEMIEGQSPFR 204
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
170-405 2.24e-13

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 72.59  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVF--LGKFRAEEVAIKKVRE--QNETD-------IKHLRKLK-HPNIIAFKGVcTQAPC----YcIIME 233
Cdd:cd07852   12 LKKLGKGAYGIVWkaIDKKTGEVVALKKIFDafRNATDaqrtfreIMFLQELNdHPNIIKLLNV-IRAENdkdiY-LVFE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YcAHGQLYEVLRAG-------RKITPRLLVdwstgiasGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK 306
Cdd:cd07852   90 Y-METDLHAVIRANiledihkQYIMYQLLK--------ALKYLHSGGVIHRDLKPSNILLNSDCRVKLADFGLARSLSQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 307 STKMSFAG-T--VA--WM-APEVIRNEP-VSEKVDIWSFGVVLWELL---------------------TGEIPYKDVDS- 357
Cdd:cd07852  161 EEDDENPVlTdyVAtrWYrAPEILLGSTrYTKGVDMWSVGCILGEMLlgkplfpgtstlnqlekiievIGRPSAEDIESi 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 358 -SAIIWGVGSN-------SLHLPVPSTCPDGFKiLMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd07852  241 qSPFAATMLESlppsrpkSLDELFPKASPDALD-LLKKLLVFNPNKRLTAEEALRH 295
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
193-374 2.33e-13

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 72.22  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 193 IKKVREQNETDIKHLRKLKHPNII---------AFKGVCTQAPCYCII---MEYCAHGQLYEVL-------------RAG 247
Cdd:cd05585   10 VMQVRKKDTSRIYALKTIRKAHIVsrsevthtlAERTVLAQVDCPFIVplkFSFQSPEKLYLVLafinggelfhhlqREG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 248 RKITPRLLVdWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-ELSDKSTKMSFAGTVAWMAPEVIRN 326
Cdd:cd05585   90 RFDLSRARF-YTAELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKlNMKDDDKTNTFCGTPEYLAPELLLG 168
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755554055 327 EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP 374
Cdd:cd05585  169 HGYTKAVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILQEPLRFPDG 216
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
165-347 2.68e-13

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 71.77  E-value: 2.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 165 EEISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:PLN00009   2 DQYEKVEKIGEGTYGVVYKARDRVtnETIALKKIRLEQEDEgvpstaireISLLKEMQHGNIVRLQDVVHSEKRLYLVFE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YcahgqLYEVLRAGRKITP------RLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH-TDAVKISDFGTSKELSDK 306
Cdd:PLN00009  82 Y-----LDLDLKKHMDSSPdfaknpRLIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRrTNALKLADFGLARAFGIP 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 755554055 307 STKMSFAGTVAWM-APEVIR-NEPVSEKVDIWSFGVVLWELLT 347
Cdd:PLN00009 157 VRTFTHEVVTLWYrAPEILLgSRHYSTPVDIWSVGCIFAEMVN 199
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
265-349 2.85e-13

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 71.84  E-value: 2.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 265 GMNYLHLH-KIIHRDLKSPNVLVTHTDA-VKISDFG----TSKELSDKSTkmsfagTVAWMAPEVIRNEPVSEKVDIWSF 338
Cdd:cd14136  131 GLDYLHTKcGIIHTDIKPENVLLCISKIeVKIADLGnacwTDKHFTEDIQ------TRQYRSPEVILGAGYGTPADIWST 204
                         90
                 ....*....|.
gi 755554055 339 GVVLWELLTGE 349
Cdd:cd14136  205 ACMAFELATGD 215
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
164-348 3.77e-13

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 71.56  E-value: 3.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 164 FEEISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNET--------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd07872    5 METYIKLEKLGEGTYATVFKGRSKLTEnlVALKEIRLEHEEgapctairEVSLLKDLKHANIVTLHDIVHTDKSLTLVFE 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA 313
Cdd:cd07872   85 YLDKDLKQYMDDCGNIMSMHNVKIFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 164
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 755554055 314 GTVAWMAPE--VIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd07872  165 VVTLWYRPPdvLLGSSEYSTQIDMWGVGCIFFEMASG 201
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
208-352 4.12e-13

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 71.24  E-value: 4.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 208 RKLKHPNIIA-FKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNV 284
Cdd:cd14040   65 KELDHPRIVKlYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKppIIHYDLKPGNI 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 285 LVTHTDA---VKISDFGTSKELSDKSTKM-------SFAGTVAWMAPE--VIRNEP--VSEKVDIWSFGVVLWELLTGEI 350
Cdd:cd14040  145 LLVDGTAcgeIKITDFGLSKIMDDDSYGVdgmdltsQGAGTYWYLPPEcfVVGKEPpkISNKVDVWSVGVIFFQCLYGRK 224

                 ..
gi 755554055 351 PY 352
Cdd:cd14040  225 PF 226
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
207-344 4.24e-13

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 72.62  E-value: 4.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIM-EYcaHGQLYEVLraGRKITPrLLVDWSTGIA----SGMNYLHLHKIIHRDLKS 281
Cdd:PHA03211 214 LRRLSHPAVLALLDVRVVGGLTCLVLpKY--RSDLYTYL--GARLRP-LGLAQVTAVArqllSAIDYIHGEGIIHRDIKT 288
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 282 PNVLVTHTDAVKISDFGTSKEL-SDKSTKMSF--AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWE 344
Cdd:PHA03211 289 ENVLVNGPEDICLGDFGAACFArGSWSTPFHYgiAGTVDTNAPEVLAGDPYTPSVDIWSAGLVIFE 354
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
173-348 4.73e-13

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 71.33  E-value: 4.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG--KFRAEEVAIKKVR-----------EQNETD----------IKHLRKLKHPNIIAFKGVCTQAPCYC 229
Cdd:PTZ00024  17 LGEGTYGKVEKAydTLTGKIVAIKKVKiieisndvtkdRQLVGMcgihfttlreLKIMNEIKHENIMGLVDVYVEGDFIN 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 230 IIMEYcAHGQLYEVLRagRKItpRLLVDWSTGIAS----GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE--- 302
Cdd:PTZ00024  97 LVMDI-MASDLKKVVD--RKI--RLTESQVKCILLqilnGLNVLHKWYFMHRDLSPANIFINSKGICKIADFGLARRygy 171
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 303 --LSDKSTKMSFAGTVAWMAPEVIR-----------NEPVSEKVDIWSFGVVLWELLTG 348
Cdd:PTZ00024 172 ppYSDTLSKDETMQRREEMTSKVVTlwyrapellmgAEKYHFAVDMWSVGCIFAELLTG 230
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
170-405 5.40e-13

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 70.49  E-value: 5.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNE-----TDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYCaHGQ 239
Cdd:cd07844    5 LDKLGEGSYATVYKGRSKLTGqlVALKEIRLEHEegapfTAIREaslLKDLKHANIVTLHDIIHTKKTLTLVFEYL-DTD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 240 LYEVL-RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAW 318
Cdd:cd07844   84 LKQYMdDCGGGLSMHNVRLFLFQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLARAKSVPSKTYSNEVVTLW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 319 MAPE--VIRNEPVSEKVDIWSFGVVLWELLTGEIPY---KDV-DSSAIIW------------GVGSN------SLHLPVP 374
Cdd:cd07844  164 YRPPdvLLGSTEYSTSLDMWGVGCIFYEMATGRPLFpgsTDVeDQLHKIFrvlgtpteetwpGVSSNpefkpySFPFYPP 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 755554055 375 ----------STCPDGFKILMKqTWQSKPRNRPSFRQTLMH 405
Cdd:cd07844  244 rplinhaprlDRIPHGEELALK-FLQYEPKKRISAAEAMKH 283
STKc_ACVR2a cd14141
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the ...
176-345 5.76e-13

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2a (or ActRIIA) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271043 [Multi-domain]  Cd Length: 290  Bit Score: 70.45  E-value: 5.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLGKFRAEEVAIK------KVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCI----IMEYCAHGQLYEVLR 245
Cdd:cd14141    6 GRFGCVWKAQLLNEYVAVKifpiqdKLSWQNEYEIYSLPGMKHENILQFIGAEKRGTNLDVdlwlITAFHEKGSLTDYLK 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 246 AGrKITPRLLVDWSTGIASGMNYLHL--------HK--IIHRDLKSPNVLVTHTDAVKISDFGTS-KELSDKSTKMSFA- 313
Cdd:cd14141   86 AN-VVSWNELCHIAQTMARGLAYLHEdipglkdgHKpaIAHRDIKSKNVLLKNNLTACIADFGLAlKFEAGKSAGDTHGq 164
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 314 -GTVAWMAPEVIR-----NEPVSEKVDIWSFGVVLWEL 345
Cdd:cd14141  165 vGTRRYMAPEVLEgainfQRDAFLRIDMYAMGLVLWEL 202
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
173-348 7.05e-13

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 71.99  E-value: 7.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVF--LGKFRAEEVAIKKVREQNETDIKHL---RKLKHPNIIAFKGVcTQAPCY---------CIIMEY---C 235
Cdd:PTZ00036  74 IGNGSFGVVYeaICIDTSEKVAIKKVLQDPQYKNRELlimKNLNHINIIFLKDY-YYTECFkknekniflNVVMEFipqT 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRAGRKItPRLLVD-WSTGIASGMNYLHLHKIIHRDLKSPNVLV---THTdaVKISDFGTSKELSDKSTKMS 311
Cdd:PTZ00036 153 VHKYMKHYARNNHAL-PLFLVKlYSYQLCRALAYIHSKFICHRDLKPQNLLIdpnTHT--LKLCDFGSAKNLLAGQRSVS 229
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 755554055 312 FAGTVAWMAPEVIRNEP-VSEKVDIWSFGVVLWELLTG 348
Cdd:PTZ00036 230 YICSRFYRAPELMLGATnYTTHIDLWSLGCIIAEMILG 267
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
169-356 7.56e-13

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 70.15  E-value: 7.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFR--AEEVAIKKVREQNETD---------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH 237
Cdd:cd07839    4 KLEKIGEGTYGTVFKAKNRetHEIVALKRVRLDDDDEgvpssalreICLLKELKHKNIVRLYDVLHSDKKLTLVFEYCDQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 238 gQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTV 316
Cdd:cd07839   84 -DLKKYFDSCNgDIDPEIVKSFMFQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSAEVVT 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 317 AWM-APEVIRNEPV-SEKVDIWSFGVVLWELLTGEIPY---KDVD 356
Cdd:cd07839  163 LWYrPPDVLFGAKLySTSIDMWSAGCIFAELANAGRPLfpgNDVD 207
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
173-361 8.57e-13

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 69.17  E-value: 8.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLG---------KFRAEEVAIKKV-------REQNETDIKHLRKLKHpNIIAFKGVCTQAPCYCIIMEYCA 236
Cdd:cd14019    9 IGEGTFSSVYKAedklhdlydRNKGRLVALKHIyptsspsRILNELECLERLGGSN-NVSGLITAFRNEDQVVAVLPYIE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 237 HGQLYEVLRagrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSKELSDKST-KMSFAG 314
Cdd:cd14019   88 HDDFRDFYR---KMSLTDIRIYLRNLFKALKHVHSFGIIHRDVKPGNFLYNrETGKGVLVDFGLAQREEDRPEqRAPRAG 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755554055 315 TVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELLTGEIP----YKDVDSSAII 361
Cdd:cd14019  165 TRGFRAPEVLfKCPHQTTAIDIWSAGVILLSILSGRFPfffsSDDIDALAEI 216
PTK_Jak1_rpt1 cd05077
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely ...
167-400 9.92e-13

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1; Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits, common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270662 [Multi-domain]  Cd Length: 266  Bit Score: 69.58  E-value: 9.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVFLGKFR----------AEEVAIK---KVREQNETDIK--------HLRKLKHPNIIAFKGVCTQA 225
Cdd:cd05077    1 IVQGEHLGRGTRTQIYAGILNykdddedegySYEKEIKvilKVLDPSHRDISlaffetasMMRQVSHKHIVLLYGVCVRD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYCAHGQLYEVLRagRKITPrLLVDW----STGIASGMNYLHLHKIIHRDLKSPNVLVTHtDAVKiSDFGTSK 301
Cdd:cd05077   81 VENIMVEEFVEFGPLDLFMH--RKSDV-LTTPWkfkvAKQLASALSYLEDKDLVHGNVCTKNILLAR-EGID-GECGPFI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 302 ELSDKS------TKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVLWEL-LTGEIPYKDVDSSAIIWGVGSNSlhLPV 373
Cdd:cd05077  156 KLSDPGipitvlSRQECVERIPWIAPECVEDSKNlSIAADKWSFGTTLWEIcYNGEIPLKDKTLAEKERFYEGQC--MLV 233
                        250       260
                 ....*....|....*....|....*..
gi 755554055 374 PSTCpDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd05077  234 TPSC-KELADLMTHCMNYDPNQRPFFR 259
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
173-405 1.27e-12

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 69.11  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQN-------------ETDIKHLRKL----KHPNIIAFKGVCTQAPCYCIIME 233
Cdd:cd14101    8 LGKGGFGTVYAGHRISDglQVAIKQISRNRvqqwsklpgvnpvPNEVALLQSVgggpGHRGVIRLLDWFEIPEGFLLVLE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 234 YCAHGQ-LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMS 311
Cdd:cd14101   88 RPQHCQdLFDYITERGALDESLARRFFKQVVEAVQHCHSKGVVHRDIKDENILVdLRTGDIKLIDFGSGATLKD-SMYTD 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPE-VIRNEPVSEKVDIWSFGVVLWELLTGEIPY-KDVDSSAiiwgvGSNSLHLPVPSTCPDgfkiLMKQTW 389
Cdd:cd14101  167 FDGTRVYSPPEwILYHQYHALPATVWSLGILLYDMVCGDIPFeRDTDILK-----AKPSFNKRVSNDCRS----LIRSCL 237
                        250
                 ....*....|....*.
gi 755554055 390 QSKPRNRPSFRQTLMH 405
Cdd:cd14101  238 AYNPSDRPSLEQILLH 253
STKc_PINK1 cd14018
Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze ...
265-400 1.45e-12

Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PINK1 contains an N-terminal mitochondrial targeting sequence, a catalytic domain, and a C-terminal regulatory region. It plays an important role in maintaining mitochondrial homeostasis. It protects cells against oxidative stress-induced apoptosis by phosphorylating the chaperone TNFR-associated protein 1 (TRAP1), also called Hsp75. Phosphorylated TRAP1 prevents cytochrome c release and peroxide-induced apoptosis. PINK1 interacts with Omi/HtrA2, a serine protease, and Parkin, an E3 ubiquitin ligase, in different pathways to promote mitochondrial health. The parkin gene is the most commonly mutated gene in autosomal recessive familial parkinsonism. Mutations within the catalytic domain of PINK1 are also associated with Parkinson's disease. The PINK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270920 [Multi-domain]  Cd Length: 313  Bit Score: 69.83  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 265 GMNYLHLHKIIHRDLKSPNVLVTHTDA----VKISDFGTSkeLSDK---------STKMSFAGTVAWMAPEVIRNEPVS- 330
Cdd:cd14018  150 GVDHLVRHGIAHRDLKSDNILLELDFDgcpwLVIADFGCC--LADDsiglqlpfsSWYVDRGGNACLMAPEVSTAVPGPg 227
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 331 -----EKVDIWSFGVVLWELLTGEIP-YKDVDSSAIIWGVGSNSLHlPVPSTCPDGFKILMKQTWQSKPRNRPSFR 400
Cdd:cd14018  228 vvinySKADAWAVGAIAYEIFGLSNPfYGLGDTMLESRSYQESQLP-ALPSAVPPDVRQVVKDLLQRDPNKRVSAR 302
STKc_TLK2 cd14041
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the ...
208-352 1.71e-12

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270943 [Multi-domain]  Cd Length: 309  Bit Score: 69.32  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 208 RKLKHPNIIA-FKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNV 284
Cdd:cd14041   65 KELDHPRIVKlYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKppIIHYDLKPGNI 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 285 LVTHTDA---VKISDFGTSKELSDKSTKM--------SFAGTVAWMAPE--VIRNEP--VSEKVDIWSFGVVLWELLTGE 349
Cdd:cd14041  145 LLVNGTAcgeIKITDFGLSKIMDDDSYNSvdgmeltsQGAGTYWYLPPEcfVVGKEPpkISNKVDVWSVGVIFYQCLYGR 224

                 ...
gi 755554055 350 IPY 352
Cdd:cd14041  225 KPF 227
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
152-399 1.75e-12

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 70.12  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 152 YKLQQQDTWEVPFEEISELQWLGSGAQGAVfLGKFRA---EEVAIKKVRE--QNETDIKH-------LRKLKHPNIIAFK 219
Cdd:cd07874    4 YSVEVGDSTFTVLKRYQNLKPIGSGAQGIV-CAAYDAvldRNVAIKKLSRpfQNQTHAKRayrelvlMKCVNHKNIISLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 220 GVCTQAPcycIIMEYCAHGQLYEVLRAGRKITPRLLVDWST------GIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVK 293
Cdd:cd07874   83 NVFTPQK---SLEEFQDVYLVMELMDANLCQVIQMELDHERmsyllyQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 294 ISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEI--PYKD-VDSsaiiWGVGSNSLH 370
Cdd:cd07874  160 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIlfPGRDyIDQ----WNKVIEQLG 235
                        250       260
                 ....*....|....*....|....*....
gi 755554055 371 LPvpstCPDGFKILmKQTWQSKPRNRPSF 399
Cdd:cd07874  236 TP----CPEFMKKL-QPTVRNYVENRPKY 259
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
262-352 2.17e-12

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 68.98  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDA---VKISDFGTSKELSDKSTKMSFA---------GTVAWMAPEVIR---N 326
Cdd:cd14090  109 IASALDFLHDKGIAHRDLKPENILCESMDKvspVKICDFDLGSGIKLSSTSMTPVttpelltpvGSAEYMAPEVVDafvG 188
                         90       100
                 ....*....|....*....|....*...
gi 755554055 327 EPVS--EKVDIWSFGVVLWELLTGEIPY 352
Cdd:cd14090  189 EALSydKRCDLWSLGVILYIMLCGYPPF 216
PTK_Tyk2_rpt1 cd05076
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is ...
167-406 2.17e-12

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270661 [Multi-domain]  Cd Length: 273  Bit Score: 68.40  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 167 ISELQWLGSGAQGAVFLGKFRAEEVA--------------------IKKVREQNETDI--------KHLRKLKHPNIIAF 218
Cdd:cd05076    1 ITQLSHLGQGTRTNIYEGRLLVEGSGepeedkelvpgrdrgqelrvVLKVLDPSHHDIalaffetaSLMSQVSHTHLVFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 219 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH-------TD 290
Cdd:cd05076   81 HGVCVRGSENIMVEEFVEHGPLDVWLRKEKgHVPMAWKFVVARQLASALSYLENKNLVHGNVCAKNILLARlgleegtSP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 291 AVKISDFGTSKELSDKSTKMSfagTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWEL-LTGEIPYKDVDSSAiIWGVGSNS 368
Cdd:cd05076  161 FIKLSDPGVGLGVLSREERVE---RIPWIAPECVPGgNSLSTAADKWGFGATLLEIcFNGEAPLQSRTPSE-KERFYQRQ 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 755554055 369 LHLPVPStCPDgFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd05076  237 HRLPEPS-CPE-LATLISQCLTYEPTQRPSFRTILRDL 272
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
169-348 3.57e-12

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 68.57  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVFLGKFR--AEEVAIKKVREQNE-----TDIKH---LRKLKHPNIIAFKGVCTQAPCYCIIMEYcAHG 238
Cdd:cd07869    9 KLEKLGEGSYATVYKGKSKvnGKLVALKVIRLQEEegtpfTAIREaslLKGLKHANIVLLHDIIHTKETLTLVFEY-VHT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 239 QLYEVL-RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA 317
Cdd:cd07869   88 DLCQYMdKHPGGLHPENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTL 167
                        170       180       190
                 ....*....|....*....|....*....|...
gi 755554055 318 WMAPE--VIRNEPVSEKVDIWSFGVVLWELLTG 348
Cdd:cd07869  168 WYRPPdvLLGSTEYSTCLDMWGVGCIFVEMIQG 200
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
170-399 6.26e-12

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 68.15  E-value: 6.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 170 LQWLGSGAQGAVfLGKFRA---EEVAIKKVRE--QNETDIKH-------LRKLKHPNIIAFKGVCTQAPCY------CII 231
Cdd:cd07875   29 LKPIGSGAQGIV-CAAYDAileRNVAIKKLSRpfQNQTHAKRayrelvlMKCVNHKNIIGLLNVFTPQKSLeefqdvYIV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 232 MEYcAHGQLYEVLRAgrKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMS 311
Cdd:cd07875  108 MEL-MDANLCQVIQM--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 312 FAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAiIWGVGSNSLHLPvpstCPDGFKILmKQTWQS 391
Cdd:cd07875  185 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHID-QWNKVIEQLGTP----CPEFMKKL-QPTVRT 258

                 ....*...
gi 755554055 392 KPRNRPSF 399
Cdd:cd07875  259 YVENRPKY 266
PK_STRAD_beta cd08226
Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain ...
199-405 1.07e-11

Pseudokinase domain of STE20-related kinase adapter protein beta; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity.STRAD-beta is also referred to as ALS2CR2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein), since the human gene encoding it is located within the juvenile ALS2 critical region on chromosome 2q33-q34. It is not linked to the development of ALS2. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. The STRAD-beta subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270864 [Multi-domain]  Cd Length: 328  Bit Score: 67.20  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 199 QNETDIKHLrkLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLHKIIH 276
Cdd:cd08226   47 QNEVVLSHF--FRHPNIMTHWTVFTEGSWLWVISPFMAYGSARGLLKTyfPEGMNEALIGNILYGAIKALNYLHQNGCIH 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 277 RDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF--------AGTVAWMAPEVIRNE--PVSEKVDIWSFGVVLWELL 346
Cdd:cd08226  125 RSVKASHILISGDGLVSLSGLSHLYSMVTNGQRSKVvydfpqfsTSVLPWLSPELLRQDlhGYNVKSDIYSVGITACELA 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 347 TGEIPYKD-------------------------------------VDS--------SAIIWGVGSNSLHLPVPSTCPDGF 381
Cdd:cd08226  205 RGQVPFQDmrrtqmllqklkgppyspldifpfpelesrmknsqsgMDSgigesvatSSMTRTMTSERLQTPSSKTFSPAF 284
                        250       260
                 ....*....|....*....|....
gi 755554055 382 KILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd08226  285 HNLVELCLQQDPEKRPSASSLLSH 308
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
169-348 1.52e-11

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 66.73  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 169 ELQWLGSGAQGAVF--LGKFRAEEVAIKKVREQNETDIKH-------LRKLKHPNII--------------AFKGVCTQA 225
Cdd:cd07854    9 DLRPLGCGSNGLVFsaVDSDCDKRVAVKKIVLTDPQSVKHalreikiIRRLDHDNIVkvyevlgpsgsdltEDVGSLTEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 226 PCYCIIMEYC--------AHGQLYEvlRAGRKITPRLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAV-KISD 296
Cdd:cd07854   89 NSVYIVQEYMetdlanvlEQGPLSE--EHARLFMYQLL--------RGLKYIHSANVLHRDLKPANVFINTEDLVlKIGD 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755554055 297 FGTSKEL-SDKSTK--MSFAGTVAWM-APEVI---RNepVSEKVDIWSFGVVLWELLTG 348
Cdd:cd07854  159 FGLARIVdPHYSHKgyLSEGLVTKWYrSPRLLlspNN--YTKAIDMWAAGCIFAEMLTG 215
PK_NRBP1_like cd13984
Pseudokinase domain of Nuclear Receptor Binding Protein 1 and similar proteins; The ...
186-405 1.87e-11

Pseudokinase domain of Nuclear Receptor Binding Protein 1 and similar proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. This subfamily is composed of NRBP1, also called MLF1-adaptor molecule (MADM), and MADML. NRBP1 was originally named based on the presence of nuclear binding and localization motifs prior to functional analyses. It is expressed ubiquitously and is found to localize in the cytoplasm, not the nucleus. NRBP1 is an adaptor protein that interacts with myeloid leukemia factor 1 (MLF1), an oncogene that enhances myeloid development of hematopoietic cells. It also interacts with the small GTPase Rac3. NRBP1 may also be involved in Golgi to ER trafficking. MADML (for MADM-Like) has been shown to be expressed throughout development in Xenopus laevis with highest expression found in the developing lens and retina. The NRBP1-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270886 [Multi-domain]  Cd Length: 256  Bit Score: 65.64  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 186 FRAEEVAIKKVREqnetdikHLRKLKHPNIIAFK----GVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVD---- 257
Cdd:cd13984   35 FKAQEEKIRAVFD-------NLIQLDHPNIVKFHrywtDVQEEKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKswkr 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 258 WSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 335
Cdd:cd13984  108 WCTQILSALSYLHSCDppIIHGNLTCDTIFIQHNGLIKIGSVAPDAIHNHVKTCREEHRNLHFFAPEYGYLEDVTTAVDI 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 336 WSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTcpdgfKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd13984  188 YSFGMCALEMAALEIQSNGEKVSANEEAIIRAIFSLEDPLQ-----KDFIRKCLSVAPQDRPSARDLLFH 252
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
265-353 4.21e-11

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 64.77  E-value: 4.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 265 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSfAGTVAWMAPEVI-RNEPVSEKVDIWSFGVVLW 343
Cdd:cd05606  110 GLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLqKGVAYDSSADWFSLGCMLY 188
                         90
                 ....*....|
gi 755554055 344 ELLTGEIPYK 353
Cdd:cd05606  189 KLLKGHSPFR 198
PTK_Jak2_rpt1 cd05078
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely ...
207-407 4.55e-11

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2; Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Despite this, the presumed pseudokinase (repeat 1) domain of Jak2 exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Inactivation of the repeat 1 domain increased Jak2 basal activity, suggesting that it modulates the kinase activity of the C-terminal catalytic (repeat 2) domain. The Jak2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270663 [Multi-domain]  Cd Length: 262  Bit Score: 64.58  E-value: 4.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRK---ITPRLLVdwSTGIASGMNYLHLHKIIHRDLKSPN 283
Cdd:cd05078   57 MSQLSHKHLVLNYGVCVCGDENILVQEYVKFGSLDTYLKKNKNcinILWKLEV--AKQLAWAMHFLEEKTLVHGNVCAKN 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 284 VLVTHTDA--------VKISDFGTSKELSDKSTKMSfagTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLT-GEIPYK 353
Cdd:cd05078  135 ILLIREEDrktgnppfIKLSDPGISITVLPKDILLE---RIPWVPPECIENpKNLSLATDKWSFGTTLWEICSgGDKPLS 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755554055 354 DVDSSAIIWgVGSNSLHLPVPSTCPdgFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd05078  212 ALDSQRKLQ-FYEDRHQLPAPKWTE--LANLINNCMDYEPDHRPSFRAIIRDLN 262
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
265-352 4.83e-11

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 65.33  E-value: 4.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 265 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELsdKSTKMSFA--GTVAWMAPEVIRNEPVSEKVDIWSFGVVL 342
Cdd:cd05599  113 AIESIHKLGYIHRDIKPDNLLLDARGHIKLSDFGLCTGL--KKSHLAYStvGTPDYIAPEVFLQKGYGKECDWWSLGVIM 190
                         90
                 ....*....|
gi 755554055 343 WELLTGEIPY 352
Cdd:cd05599  191 YEMLIGYPPF 200
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
176-347 6.02e-11

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 64.67  E-value: 6.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 176 GAQGAVFLGKFRAEEVAIK------KVREQNETDIKHLRKLKHPNIIAF-----KGVCTQAPCYcIIMEYCAHGQLYEVL 244
Cdd:cd14140    6 GRFGCVWKAQLMNEYVAVKifpiqdKQSWQSEREIFSTPGMKHENLLQFiaaekRGSNLEMELW-LITAFHDKGSLTDYL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 RaGRKITPRLLVDWSTGIASGMNYLHL---------HK--IIHRDLKSPNVLVTHTDAVKISDFGTS------KELSDKS 307
Cdd:cd14140   85 K-GNIVSWNELCHIAETMARGLSYLHEdvprckgegHKpaIAHRDFKSKNVLLKNDLTAVLADFGLAvrfepgKPPGDTH 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 755554055 308 TKMsfaGTVAWMAPEVIRNEPVSE-----KVDIWSFGVVLWELLT 347
Cdd:cd14140  164 GQV---GTRRYMAPEVLEGAINFQrdsflRIDMYAMGLVLWELVS 205
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
184-350 6.22e-11

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 65.87  E-value: 6.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 184 GKFRAEEVAIKKVRE------QNETDIKHLRKLKHPNIIAFKGVcTQAPCYCIIM----EYCAHGQLYE---------VL 244
Cdd:PHA03210 188 GKPKCERLIAKRVKAgsraaiQLENEILALGRLNHENILKIEEI-LRSEANTYMItqkyDFDLYSFMYDeafdwkdrpLL 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 RAGRKITPRLLvdwstgiaSGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFA--GTVAWMAPE 322
Cdd:PHA03210 267 KQTRAIMKQLL--------CAVEYIHDKKLIHRDIKLENIFLNCDGKIVLGDFGTAMPFEKEREAFDYGwvGTVATNSPE 338
                        170       180
                 ....*....|....*....|....*...
gi 755554055 323 VIRNEPVSEKVDIWSFGVVLWELLTGEI 350
Cdd:PHA03210 339 ILAGDGYCEITDIWSCGLILLDMLSHDF 366
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
173-298 7.43e-11

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 60.92  E-value: 7.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFL--GKFRAEEVAIKKVREQN---------ETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLY 241
Cdd:cd13968    1 MGEGASAKVFWaeGECTTIGVAVKIGDDVNneegedlesEMDILRRLKGLELNIPKVLVTEDVDGPNILLMELVKGGTLI 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755554055 242 EVLRAGR------KITPRLLvdwstgiASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFG 298
Cdd:cd13968   81 AYTQEEEldekdvESIMYQL-------AECMRLLHSFHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
262-350 9.02e-11

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 64.77  E-value: 9.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 262 IASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTS-KELSDKSTKMSF-AGTVAWMAPEVIRNEP-VSEKVDIWSF 338
Cdd:cd07853  112 ILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLArVEEPDESKHMTQeVVTQYYRAPEILMGSRhYTSAVDIWSV 191
                         90
                 ....*....|..
gi 755554055 339 GVVLWELLTGEI 350
Cdd:cd07853  192 GCIFAELLGRRI 203
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
173-405 1.05e-10

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 63.06  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 173 LGSGAQGAVFLGKFRAE--EVAIKKVREQNETDIKHLrklkhPN-------IIAFKGVCT-------------QAPCYCI 230
Cdd:cd14100    8 LGSGGFGSVYSGIRVADgaPVAIKHVEKDRVSEWGEL-----PNgtrvpmeIVLLKKVGSgfrgvirlldwfeRPDSFVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 231 IMEYCAHGQ-LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVT-HTDAVKISDFGTSKELSDkST 308
Cdd:cd14100   83 VLERPEPVQdLFDFITERGALPEELARSFFRQVLEAVRHCHNCGVLHRDIKDENILIDlNTGELKLIDFGSGALLKD-TV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 309 KMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEIPYKDvDSSAIiwgVGSNSLHLPVPSTCpdgfKILMKQ 387
Cdd:cd14100  162 YTDFDGTRVYSPPEWIRfHRYHGRSAAVWSLGILLYDMVCGDIPFEH-DEEII---RGQVFFRQRVSSEC----QHLIKW 233
                        250
                 ....*....|....*...
gi 755554055 388 TWQSKPRNRPSFRQTLMH 405
Cdd:cd14100  234 CLALRPSDRPSFEDIQNH 251
PTK_Jak3_rpt1 cd14208
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is ...
207-407 1.50e-10

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3; Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit, common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a cytoplasmic (or nonreceptor) PTK containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. Jaks are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271110 [Multi-domain]  Cd Length: 260  Bit Score: 63.00  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 207 LRKLKHPNIIAFKGVCTqAPCYCIIMEYCAHGQLYEVLRAGRKITPrLLVDWSTGI----ASGMNYLHLHKIIHRDLKSP 282
Cdd:cd14208   56 MSQISHKHLVLLHGVCV-GKDSIMVQEFVCHGALDLYLKKQQQKGP-VAISWKLQVvkqlAYALNYLEDKQLVHGNVSAK 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 283 NVLVTHTDA------VKISDFGTSKELSDKSTkmsFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLT-GEIPYKD 354
Cdd:cd14208  134 KVLLSREGDkgsppfIKLSDPGVSIKVLDEEL---LAERIPWVAPECLSDpQNLALEADKWGFGATLWEIFSgGHMPLSA 210
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755554055 355 VDSSAIIWGVGSnslHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD 407
Cdd:cd14208  211 LDPSKKLQFYND---RKQLPAPHWIELASLIQQCMSYNPLLRPSFRAIIRDLN 260
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
171-360 1.54e-10

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 63.25  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 171 QWLGSGAQGAVFLGKFRA--EEVAIKKV--REQNETDIK-HLRKLKHPNI----------IAFKGVCTQAPCYCIIMEYC 235
Cdd:cd14171   12 QKLGTGISGPVRVCVKKStgERFALKILldRPKARTEVRlHMMCSGHPNIvqiydvyansVQFPGESSPRARLLIVMELM 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 236 AHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHT--DA-VKISDFGTSKElsDKSTKMSF 312
Cdd:cd14171   92 EGGELFDRISQHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLKPENLLLKDNseDApIKLCDFGFAKV--DQGDLMTP 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755554055 313 AGTVAWMAPEVIRNE-----------PVS------EKVDIWSFGVVLWELLTGEIP-YKDVDSSAI 360
Cdd:cd14171  170 QFTPYYVAPQVLEAQrrhrkersgipTSPtpytydKSCDMWSLGVIIYIMLCGYPPfYSEHPSRTI 235
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
189-350 2.33e-10

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 63.01  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 189 EEVAIKKVReQNET-------DIKHLRKL--------KHpnIIAFKGVCTQAPCYCIIMEyCAHGQLYEVL--------- 244
Cdd:cd14135   27 QEVAIKIIR-NNELmhkaglkELEILKKLndadpddkKH--CIRLLRHFEHKNHLCLVFE-SLSMNLREVLkkygknvgl 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 245 --RAGRKITPRLLVdwstgiasGMNYLHLHKIIHRDLKSPNVLVTH-TDAVKISDFGTSKELSDkSTKMSFAGTVAWMAP 321
Cdd:cd14135  103 niKAVRSYAQQLFL--------ALKHLKKCNILHADIKPDNILVNEkKNTLKLCDFGSASDIGE-NEITPYLVSRFYRAP 173
                        170       180
                 ....*....|....*....|....*....
gi 755554055 322 EVIRNEPVSEKVDIWSFGVVLWELLTGEI 350
Cdd:cd14135  174 EIILGLPYDYPIDMWSVGCTLYELYTGKI 202
PK_TRB2 cd14022
Pseudokinase domain of Tribbles Homolog 2; The pseudokinase domain shows similarity to protein ...
223-405 2.91e-10

Pseudokinase domain of Tribbles Homolog 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. TRB2 binds and negatively regulates the mitogen activated protein kinase (MAPK) kinases, MKK7 and MEK1, which are activators of the MAPKs, ERK and JNK. It controls the activation of inflammatory monocytes, which is essential in innate immune responses and the pathogenesis of inflammatory diseases such as atherosclerosis. TRB2 expression is down-regulated in human acute myeloid leukaemia (AML), which may lead to enhanced cell survival and pathogenesis of the disease. TRB2 is one of three Tribbles Homolog (TRB) proteins present in vertebrates that are encoded by three separate genes. TRB proteins interact with many proteins involved in signalling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, and gene expression. The TRB2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270924 [Multi-domain]  Cd Length: 242  Bit Score: 61.59  E-value: 2.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 223 TQAPCYCI--------IMEYC------------AHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSP 282
Cdd:cd14022   34 SLAPCFCLpahsninqITEIIlgetkayvfferSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 283 NVLVTHTD--AVKISDF-------GTSKELSDKStkmsfaGTVAWMAPEVIR-NEPVSEKV-DIWSFGVVLWELLTGEIP 351
Cdd:cd14022  114 KFVFKDEErtRVKLESLedayilrGHDDSLSDKH------GCPAYVSPEILNtSGSYSGKAaDVWSLGVMLYTMLVGRYP 187
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755554055 352 YKDVDSSAIIWGVGSNslHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 405
Cdd:cd14022  188 FHDIEPSSLFSKIRRG--QFNIPETLSPKAKCLIRSILRREPSERLTSQEILDH 239
STKc_SHIK cd13974
Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs ...
269-406 3.54e-10

Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SHIK, also referred to as STK40 or LYK4, is a cytoplasmic and nuclear protein that is involved in the negative regulation of NF-kappaB- and p53-mediated transcription. It was identified as a protein related to SINK, a p65-interacting protein that inhibits p65 phosphorylation by the catalytic subunit of PKA, thereby inhibiting transcriptional competence of NF-kappaB. The SHIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270876 [Multi-domain]  Cd Length: 290  Bit Score: 62.04  E-value: 3.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755554055 269 LHLHKIIHRDLKSPN-VLVTHTDAVKISDFGTSKEL-SDKSTKMSFAGTVAWMAPEVIRNEPVSEK-VDIWSFGVVLWEL 345
Cdd:cd13974  148 LHKKNIVHRDLKLGNmVLNKRTRKITITNFCLGKHLvSEDDLLKDQRGSPAYISPDVLSGKPYLGKpSDMWALGVVLFTM 227
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755554055 346 LTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 406
Cdd:cd13974  228 LYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLNPQKRLTASEVLDSL 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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