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Conserved domains on  [gi|688585902|ref|XP_009289482|]
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transcription factor COE1 isoform X1 [Danio rerio]

Protein Classification

transcription factor COE( domain architecture ID 11242836)

transcription factor COE similar to human COE1 and COE2 that recognize variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3, and may play roles in B-cell development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 3.32e-172

Transcription factor COE1 DNA-binding domain;


:

Pssm-ID: 435333  Cd Length: 227  Bit Score: 487.81  E-value: 3.32e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902   21 GAGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKEST 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  101 GEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688585902  181 VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 264-348 6.56e-57

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


:

Pssm-ID: 238580  Cd Length: 85  Bit Score: 185.93  E-value: 6.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 264 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 343
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 688585902 344 FIYTA 348
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 349-392 8.57e-27

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 102.56  E-value: 8.57e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 688585902  349 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALY 392
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 3.32e-172

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 487.81  E-value: 3.32e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902   21 GAGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKEST 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  101 GEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688585902  181 VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 4.40e-165

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 469.22  E-value: 4.40e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  35 GVLDAnTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKESTGEKTNNGIHYRLQL 114
Cdd:cd11606    1 GVTDP-SAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 115 LYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606   80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 688585902 195 NQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:cd11606  160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 264-348 6.56e-57

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 185.93  E-value: 6.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 264 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 343
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 688585902 344 FIYTA 348
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 349-392 8.57e-27

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 102.56  E-value: 8.57e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 688585902  349 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALY 392
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 264-346 1.38e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  264 PCIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGt 340
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 688585902  341 PGRFIY 346
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
264-347 3.60e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.19  E-value: 3.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902   264 PCIKAISPSEGWTTGGATVIIIGDNFFDGlQVIFGTMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 336
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 688585902   337 cKGTPGRFIYT 347
Cdd:smart00429  81 -PSSPQPFTYV 90
HLH smart00353
helix loop helix domain;
354-394 3.39e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 38.74  E-value: 3.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 688585902   354 IDYGFQRLQKVIPRHPGDpERLPKEVILKRAADLVEALYGM 394
Cdd:smart00353  11 INEAFDELRSLLPTLPKN-KKLSKAEILRLAIEYIKSLQEE 50
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
21-247 3.32e-172

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 487.81  E-value: 3.32e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902   21 GAGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKEST 100
Cdd:pfam16422   1 GPSMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  101 GEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP 180
Cdd:pfam16422  81 DEKTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDP 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688585902  181 VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 161 VIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 4.40e-165

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 469.22  E-value: 4.40e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  35 GVLDAnTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTSFVGFVEKEKESTGEKTNNGIHYRLQL 114
Cdd:cd11606    1 GVTDP-SAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 115 LYSNGIRTEQDFYVRLIDSMTKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606   80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 688585902 195 NQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:cd11606  160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 264-348 6.56e-57

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 185.93  E-value: 6.56e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 264 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 343
Cdd:cd01175    1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                 ....*
gi 688585902 344 FIYTA 348
Cdd:cd01175   81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 349-392 8.57e-27

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 102.56  E-value: 8.57e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 688585902  349 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALY 392
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 264-346 1.38e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 1.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902  264 PCIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGt 340
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 688585902  341 PGRFIY 346
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 264-347 4.84e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.09  E-value: 4.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 264 PCIKAISPSEGWTTGGATVIIIGDNFFDG--LQVIFGTMLVWSEL-ITPHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 338
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79


                 ....*....
gi 688585902 339 GTPGRFIYT 347
Cdd:cd00102   80 SSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
264-347 3.60e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.19  E-value: 3.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902   264 PCIKAISPSEGWTTGGATVIIIGDNFFDGlQVIFGTMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 336
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 688585902   337 cKGTPGRFIYT 347
Cdd:smart00429  81 -PSSPQPFTYV 90
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 266-347 2.13e-04

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 40.73  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 266 IKAISPSEGWTTGGATVIIIGDNF-FDGLQVIFG----TMLVW-------SELITPHAIRVQTPPRHIPGV-----VEVT 328
Cdd:cd00602    3 ICRVSSLSGSVNGGDEVFLLCDKVnKPDIKVWFGekgpGETVWeaeamfrQEDVRQVAIVFKTPPYHNKWItrpvqVPIQ 82

                         90
                 ....*....|....*....
gi 688585902 329 LSYKSKQfCKGTPGRFIYT 347
Cdd:cd00602   83 LVRPDDR-KRSEPLTFTYT 100
HLH smart00353
helix loop helix domain;
354-394 3.39e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 38.74  E-value: 3.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 688585902   354 IDYGFQRLQKVIPRHPGDpERLPKEVILKRAADLVEALYGM 394
Cdd:smart00353  11 INEAFDELRSLLPTLPKN-KKLSKAEILRLAIEYIKSLQEE 50
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 264-347 1.39e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 38.20  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688585902 264 PCIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPRHIP--GVVEVTLSYKSKQFCK 338
Cdd:cd00603    1 PVITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgeGPVEVTVDGANVSARV 80


                 ....*....
gi 688585902 339 GTPGRFIYT 347
Cdd:cd00603   81 LSNTTFTYV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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