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Conserved domains on  [gi|568927334|ref|XP_006538295|]
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cilia- and flagella-associated protein 206 isoform X1 [Mus musculus]

Protein Classification

DUF3508 domain-containing protein( domain architecture ID 10572243)

DUF3508 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
214-491 4.61e-143

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


:

Pssm-ID: 432264  Cd Length: 273  Bit Score: 415.89  E-value: 4.61e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  214 ILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKV--TNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVE 291
Cdd:pfam12018   1 ILEEAIPATTEHIDKELEEAQELAYKYTALLEKLkeSTNPYRVSEEQLERLKQALYNVRQHEAFLRILLSDVITCAQEVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  292 MMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLD 371
Cdd:pfam12018  81 VLLKRLQAVMEKLKDTLKSKTAVPTEQVFPHFIALSKLWSGLQDELNLLSVLNNLLASLQPFLGSHAELFPEEVLESLLE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  372 GVVVKSDltrieehMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFS 451
Cdd:pfam12018 161 EVEVKTD-------ETERVNPSDFKEQEWLFPETTANFDKLPLDYNGFCAWTLVVRDGLLLPGNPSIGVLKYKDKYYAFS 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 568927334  452 TRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFE 491
Cdd:pfam12018 234 SKEAAYEFASDPDRYIAAVREKAKKNPELIQLLELHQQFA 273
 
Name Accession Description Interval E-value
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
214-491 4.61e-143

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 432264  Cd Length: 273  Bit Score: 415.89  E-value: 4.61e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  214 ILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKV--TNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVE 291
Cdd:pfam12018   1 ILEEAIPATTEHIDKELEEAQELAYKYTALLEKLkeSTNPYRVSEEQLERLKQALYNVRQHEAFLRILLSDVITCAQEVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  292 MMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLD 371
Cdd:pfam12018  81 VLLKRLQAVMEKLKDTLKSKTAVPTEQVFPHFIALSKLWSGLQDELNLLSVLNNLLASLQPFLGSHAELFPEEVLESLLE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  372 GVVVKSDltrieehMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFS 451
Cdd:pfam12018 161 EVEVKTD-------ETERVNPSDFKEQEWLFPETTANFDKLPLDYNGFCAWTLVVRDGLLLPGNPSIGVLKYKDKYYAFS 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 568927334  452 TRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFE 491
Cdd:pfam12018 234 SKEAAYEFASDPDRYIAAVREKAKKNPELIQLLELHQQFA 273
 
Name Accession Description Interval E-value
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
214-491 4.61e-143

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 432264  Cd Length: 273  Bit Score: 415.89  E-value: 4.61e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  214 ILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKV--TNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVE 291
Cdd:pfam12018   1 ILEEAIPATTEHIDKELEEAQELAYKYTALLEKLkeSTNPYRVSEEQLERLKQALYNVRQHEAFLRILLSDVITCAQEVE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  292 MMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLD 371
Cdd:pfam12018  81 VLLKRLQAVMEKLKDTLKSKTAVPTEQVFPHFIALSKLWSGLQDELNLLSVLNNLLASLQPFLGSHAELFPEEVLESLLE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927334  372 GVVVKSDltrieehMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFS 451
Cdd:pfam12018 161 EVEVKTD-------ETERVNPSDFKEQEWLFPETTANFDKLPLDYNGFCAWTLVVRDGLLLPGNPSIGVLKYKDKYYAFS 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 568927334  452 TRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFE 491
Cdd:pfam12018 234 SKEAAYEFASDPDRYIAAVREKAKKNPELIQLLELHQQFA 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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