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Conserved domains on  [gi|568926093|ref|XP_006537689|]
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inversin isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 2.21e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 2.21e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666   240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 5.80e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.24  E-value: 5.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926093  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 617-890 4.73e-11

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 67.50  E-value: 4.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 5.49e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*.
gi 568926093  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767     1 EEEELQRMNRAATLIQALWRGYKVRK 26
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.50e-04

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568926093   221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 6.67e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 6.67e-04
                          10        20
                  ....*....|....*....|....*..
gi 568926093  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKELKKKK 32
C11orf65 super family cl41231
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 7.54e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


The actual alignment was detected with superfamily member cd21090:

Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 7.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090     4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 2.21e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 2.21e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666   240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 5.80e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.24  E-value: 5.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926093  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 340-558 5.88e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 5.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  340 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 412
Cdd:PHA03100   49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  413 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 490
Cdd:PHA03100  127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926093  491 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 558
Cdd:PHA03100  190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
398-490 4.90e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.33  E-value: 4.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   398 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 477
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568926093   478 VLMENNADPNIQD 490
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-420 2.50e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 96.67  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfma 138
Cdd:PHA02876  156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  139 pgevDTQDKNKQTALHWSAYYNNPEHAKLLIkHDSNIGIP--DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTeslLNW 216
Cdd:PHA02876  233 ----NRSNINKNDLSLLKAIRNEDLETSLLL-YDAGFSVNsiDDCKNTPLHHAS--QAPSLSRLVPKLLERGAD---VNA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAAllgTFGRHAQIVHLLLERNkSGTIPSDSQGATP 296
Cdd:PHA02876  303 KNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAS---TLDRNKDIVITLLELG-ANVNARDYCDKTP 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNddvlrTMLSLKSDID----INMSDKYGGTALHAAALSG 372
Cdd:PHA02876  379 IHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTN-----PYMSVKTLIDrganVNSKNKDLSTPLHYACKKN 453

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 568926093  373 -HVSTVKLLLDNDAQVDATDVMKHTPLFRAceMGHRDVIQTLIKGGARV 420
Cdd:PHA02876  454 cKLDVIEMLLDNGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
85-179 1.29e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093    85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 568926093   165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 617-890 4.73e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 67.50  E-value: 4.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 295-501 8.26e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 8.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  295 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 365
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  366 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 428
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  429 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 498
Cdd:cd22192   171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239


                  ...
gi 568926093  499 WSC 501
Cdd:cd22192   240 WTY 242
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 21-236 9.09e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 9.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   21 AAVNGDKGALQRLIVGNSAlrDKEDR--FGRTPLMYCVLADRVDCADALLKAGAD-VNKTDHSR----RTALHLAAQKGN 93
Cdd:cd22192    24 AAKENDVQAIKKLLKCPSC--DLFQRgaLGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAVVNQN 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   94 YRFMKLLLTRRAnwmqkdlEEMTPLHLSTR-HRSPKClalLLKFmapGEvdtqdknkqTALHWSAYYNNPEHAKLLIKHD 172
Cdd:cd22192   102 LNLVRELIARGA-------DVVSPRATGTFfRPGPKN---LIYY---GE---------HPLSFAACVGNEEIVRLLIEHG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926093  173 SNIGIPDVEGKIPLH---WAANHKdpSAVHTVRCIL------DAAPTESLLNwqdYEGRTPLHFAVADGNLTV 236
Cdd:cd22192   160 ADIRAQDSLGNTVLHilvLQPNKT--FACQMYDLILsydkedDLQPLDLVPN---NQGLTPFKLAAKEGNIVM 227
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 5.49e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*.
gi 568926093  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767     1 EEEELQRMNRAATLIQALWRGYKVRK 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-76 2.15e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.15e-04
                            10        20
                    ....*....|....*....|....*....
gi 568926093     48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 426-455 3.96e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.96e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 568926093    426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.50e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568926093   221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 6.67e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 6.67e-04
                          10        20
                  ....*....|....*....|....*..
gi 568926093  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKELKKKK 32
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 228-481 6.81e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 6.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   228 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 306
Cdd:TIGR00870   24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   307 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 385
Cdd:TIGR00870   95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   386 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 442
Cdd:TIGR00870  153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568926093   443 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 481
Cdd:TIGR00870  230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 7.54e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 7.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090     4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
274-564 2.21e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 2.21e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  274 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 353
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 433
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  514 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 564
Cdd:COG0666   240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
310-598 2.28e-49

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 177.07  E-value: 2.28e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  310 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:COG0666     3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  390 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 469
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  470 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLE 549
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLE 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568926093  550 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAA 598
Cdd:COG0666   241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
204-497 5.72e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.36  E-value: 5.72e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  204 ILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALlgtfgRHAQIVHLLLERNK 283
Cdd:COG0666     3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL-----AGDLLVALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  284 SGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRtMLsLKSDIDINMSDKYGGT 363
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  364 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 443
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926093  444 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 497
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-240 5.80e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.24  E-value: 5.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926093  179 DVEGKIPLHWAANHKDPSAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666   216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-328 1.93e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.93e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   19 HAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIgip 178
Cdd:COG0666   105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE--AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV--- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  179 dvegkiplhwaanhkdpsavhtvrcildaaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTP 258
Cdd:COG0666   180 ------------------------------------NARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTA 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  259 LHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRT 328
Cdd:COG0666   223 LDLAAENG----NLEIVKLLLEAGADLNAK-DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-528 2.34e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 2.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   96 FMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNI 175
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  176 GIPDVEGKIPLHWAANHKDpsavhtvrcildaaptesllnwqdyegrtplhfavadgnltvvdvltsyescnitsydnlf 255
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGD------------------------------------------------------------- 99

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  256 rtplhwaallgtfgrhAQIVHLLLErnksgtipsdsQGAtplhyaaqsnfaetvkvflqhpsvkddsdlegrtsfmwaag 335
Cdd:COG0666   100 ----------------LEIVKLLLE-----------AGA----------------------------------------- 111

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  336 kgnddvlrtmlslksdiDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 415
Cdd:COG0666   112 -----------------DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  416 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRT 495
Cdd:COG0666   175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254

                         410       420       430
                  ....*....|....*....|....*....|...
gi 568926093  496 ALHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 528
Cdd:COG0666   255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-194 2.10e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.15  E-value: 2.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093    2 NISEDVLSTGSSLASQVHAAAVNGDKGALQRLIvGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSR 81
Cdd:COG0666    75 AAGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   82 RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNN 161
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA--DVNAKDNDGKTALDLAAENGN 231

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568926093  162 PEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKD 194
Cdd:COG0666   232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-359 3.86e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.38  E-value: 3.86e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   64 ADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPgeVD 143
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD--IN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  144 TQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAvhtVRCILDA-APteslLNWQDYEGR 222
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI---VKLLLEAgAD----VNAQDNDGN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  223 TPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQ 302
Cdd:COG0666   155 TPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENG----HLEIVKLLLEAGADVNAK-DNDGKTALDLAAE 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568926093  303 SNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDK 359
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-186 1.08e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 1.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   19 HAAAVNGDKGALQRLIvGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666   125 HLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666   204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA--DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281


                  ....*...
gi 568926093  179 DVEGKIPL 186
Cdd:COG0666   282 LLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 340-558 5.88e-23

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 102.82  E-value: 5.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  340 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 412
Cdd:PHA03100   49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  413 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 490
Cdd:PHA03100  127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926093  491 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 558
Cdd:PHA03100  190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
398-490 4.90e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 91.33  E-value: 4.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   398 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 477
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568926093   478 VLMENNADPNIQD 490
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
431-522 6.55e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 6.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   431 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 510
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|..
gi 568926093   511 LLLDFAAFPNQM 522
Cdd:pfam12796   79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
365-457 5.00e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 5.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   365 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 444
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568926093   445 ILIENKINPNVQD 457
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-420 2.50e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 96.67  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   59 DRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfma 138
Cdd:PHA02876  156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  139 pgevDTQDKNKQTALHWSAYYNNPEHAKLLIkHDSNIGIP--DVEGKIPLHWAAnhKDPSAVHTVRCILDAAPTeslLNW 216
Cdd:PHA02876  233 ----NRSNINKNDLSLLKAIRNEDLETSLLL-YDAGFSVNsiDDCKNTPLHHAS--QAPSLSRLVPKLLERGAD---VNA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAAllgTFGRHAQIVHLLLERNkSGTIPSDSQGATP 296
Cdd:PHA02876  303 KNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAS---TLDRNKDIVITLLELG-ANVNARDYCDKTP 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNddvlrTMLSLKSDID----INMSDKYGGTALHAAALSG 372
Cdd:PHA02876  379 IHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTN-----PYMSVKTLIDrganVNSKNKDLSTPLHYACKKN 453

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 568926093  373 -HVSTVKLLLDNDAQVDATDVMKHTPLFRAceMGHRDVIQTLIKGGARV 420
Cdd:PHA02876  454 cKLDVIEMLLDNGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
Ank_2 pfam12796
Ankyrin repeats (3 copies);
297-391 4.09e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.94  E-value: 4.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   297 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLksdIDINMSDkYGGTALHAAALSGHVST 376
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 568926093   377 VKLLLDNDAQVDATD 391
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 214-552 5.20e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 95.90  E-value: 5.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  214 LNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-CNITSYDNLfrTPLHWA------------------------ALLGTF 268
Cdd:PHA02876  171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGAdVNIIALDDL--SVLECAvdsknidtikaiidnrsninkndlSLLKAI 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  269 GRHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQS-NFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGND-DVLRTML 346
Cdd:PHA02876  249 RNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLI 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  347 SLKSDIdiNMSDKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 425
Cdd:PHA02876  329 MLGADV--NAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  426 DGHSLLHWAALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNG 504
Cdd:PHA02876  407 KIGTALHFALCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNC 454

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 568926093  505 YLDAIKLLLDFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 552
Cdd:PHA02876  455 KLDVIEMLLDNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
Ank_2 pfam12796
Ankyrin repeats (3 copies);
464-552 2.73e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 2.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   464 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 543
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76


                   ....*....
gi 568926093   544 IQFMLEHGA 552
Cdd:pfam12796   77 VKLLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-262 4.34e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 91.18  E-value: 4.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   62 DCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGE 141
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  142 VdtQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKdpsavhtvRCILDAAPTESLLNWQDYEG 221
Cdd:PHA02874  185 V--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--------RSAIELLINNASINDQDIDG 254

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568926093  222 RTPLHFAVA-DGNLTVVDVLTsYESCNITSYDNLFRTPLHWA 262
Cdd:PHA02874  255 STPLHHAINpPCDIDIIDILL-YHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
85-179 1.29e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093    85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 568926093   165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 252-499 2.46e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 89.31  E-value: 2.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  252 DNLFRTPLHwaALLGTF-GRHAQIVHLLLER----NKSgtipsDSQGATPLHYAAQsnFAETVkvflqhpsvkddsdleg 326
Cdd:PHA03095   44 GEYGKTPLH--LYLHYSsEKVKDIVRLLLEAgadvNAP-----ERCGFTPLHLYLY--NATTL----------------- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  327 rtsfmwaagkgndDVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL----- 398
Cdd:PHA03095   98 -------------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllk 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  399 FRACEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCM 476
Cdd:PHA03095  162 SRNANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCK 236

                         250       260
                  ....*....|....*....|....*..
gi 568926093  477 AVLM----ENNADPNIQDKEGRTALHW 499
Cdd:PHA03095  237 RSLVlpllIAGISINARNRYGQTPLHY 263
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-319 7.35e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 87.77  E-value: 7.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   32 RLIVGNSALRDKEDRFGRTPLMYCV---LADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGN-YRFMKLLLTRRANW 107
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  108 MQKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHwsAYYN----NPEHAKLLIKHDSNIGIPDVE 181
Cdd:PHA03095  111 NAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGA--DVNALDLYGMTPLA--VLLKsrnaNVELLRLLIDAGADVYAVDDR 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  182 GKIPLHWAAN--HKDPSAVHT-VRCILDAAPTESLlnwqdyeGRTPLHFAVADG---NLTVVDVLTSYESCNITsyDNLF 255
Cdd:PHA03095  187 FRSLLHHHLQsfKPRARIVRElIRAGCDPAATDML-------GNTPLHSMATGSsckRSLVLPLLIAGISINAR--NRYG 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926093  256 RTPLHWAAllgTFGRHAQIVHLLlernKSGTIPS--DSQGATPLHYAAQSNFAETVKVFL-QHPSVK 319
Cdd:PHA03095  258 QTPLHYAA---VFNNPRACRRLI----ALGADINavSSDGNTPLSLMVRNNNGRAVRAALaKNPSAE 317
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 211-425 2.16e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.79  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  211 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLG-TFGRHAQIVHLLLERNKSGTIPs 289
Cdd:PHA03100   25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKyNLTDVKEIVKLLLEYGANVNAP- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  290 DSQGATPLHYAAQ--SNFAETVKVFLQHPSVKDDSDLEGRTSF-MWAAGKGND-DVLRTMLS--------------LKSD 351
Cdd:PHA03100  103 DNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLhLYLESNKIDlKILKLLIDkgvdinaknrvnylLSYG 182

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926093  352 IDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 425
Cdd:PHA03100  183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PHA03095 PHA03095
ankyrin-like protein; Provisional
 166-464 1.41e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 80.84  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  166 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 244
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  245 SCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHyaaqsnfaetvkVFLQHPSVkddsdl 324
Cdd:PHA03095  107 GADVNAKDKVGRTPLH--VYLSGFNINPKVIRLLLRKGADVN-ALDLYGMTPLA------------VLLKSRNA------ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  325 egrtsfmwaagkgNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRAC 402
Cdd:PHA03095  166 -------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMA 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568926093  403 EMG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 464
Cdd:PHA03095  231 TGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-146 3.76e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 3.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093    52 LMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQkdLEEMTPLHLSTRHRSPKCLA 131
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|....*
gi 568926093   132 LLLKFMApgEVDTQD 146
Cdd:pfam12796   79 LLLEKGA--DINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 348-552 4.25e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 4.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  348 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 421
Cdd:PHA03095   34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  422 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 494
Cdd:PHA03095  112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  495 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 552
Cdd:PHA03095  189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-421 5.03e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 5.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   39 ALRDKEDRFGRTPLM-YCVLADRVDCAD--ALLKAGADVNKTDHSRRTALHLaaqkgnyrFMKllltrranwmqkdleem 115
Cdd:PHA03095    2 EEDESVDIIMEAALYdYLLNASNVTVEEvrRLLAAGADVNFRGEYGKTPLHL--------YLH----------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  116 tplhlSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNN-PEHAKLLIKHDSNIGIPDVEGKIPLHwaanhkd 194
Cdd:PHA03095   57 -----YSSEKVKDIVRLLLE--AGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLH------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  195 psaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVVDVLTSyESCNITSYDNLFRTPLHwaALL 265
Cdd:PHA03095  123 ---VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELLRLLID-AGADVYAVDDRFRSLLH--HHL 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  266 GTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLR 343
Cdd:PHA03095  196 QSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACR 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  344 TMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTpLFRACEMGHRD--------VIQTLIK 415
Cdd:PHA03095  275 RLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT-LNTASVAGGDIpsdatrlcVAKVVLR 348


                  ....*.
gi 568926093  416 GGARVD 421
Cdd:PHA03095  349 GAFSLL 354
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-111 9.03e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 9.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093    19 HAAAVNGDKGALQRLIVGNSALrDKEDRFGRTPLMYCVLADRVDCADALLKaGADVNKTDHsRRTALHLAAQKGNYRFMK 98
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568926093    99 LLLTRRANWMQKD 111
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 17-201 1.40e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 77.76  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   17 QVHAAAVNGDKGALQRLIVGNSALRDKeDRFGRTPLMycVLADRVDCADALLK----AGADVNKTDHSRRTALHLAAQ-- 90
Cdd:PHA03095  122 HVYLSGFNINPKVIRLLLRKGADVNAL-DLYGMTPLA--VLLKSRNANVELLRllidAGADVYAVDDRFRSLLHHHLQsf 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   91 KGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLaLLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:PHA03095  199 KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRS-LVLPLLIAGiSINARNRYGQTPLHYAAVFNNPRACRRLI 277

                         170       180       190
                  ....*....|....*....|....*....|..
gi 568926093  170 KHDSNIGIPDVEGKIPLHWAANHKDPSAVHTV 201
Cdd:PHA03095  278 ALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 338-536 1.53e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 77.31  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  338 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 417
Cdd:PHA02874  103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  418 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 497
Cdd:PHA02874  181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568926093  498 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 536
Cdd:PHA02874  259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 354-561 2.26e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 2.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  354 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 410
Cdd:PHA02874   28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  411 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 490
Cdd:PHA02874  108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926093  491 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 561
Cdd:PHA02874  188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-252 3.08e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 3.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   153 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 232
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72

                           90       100
                   ....*....|....*....|
gi 568926093   233 NLTVVDVLTSYEsCNITSYD 252
Cdd:pfam12796   73 HLEIVKLLLEKG-ADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 374-552 3.54e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.86  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  374 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 448
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  449 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 524
Cdd:PHA03100   95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568926093  525 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 552
Cdd:PHA03100  175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 365-533 4.06e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.80  E-value: 4.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  365 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 441
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  442 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 520
Cdd:PHA02875  150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229

                         170
                  ....*....|....
gi 568926093  521 QMENNE-ERYTPLD 533
Cdd:PHA02875  230 IMFMIEgEECTILD 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
225-323 4.09e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 4.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   225 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGtipSDSQGATPLHYAAQSN 304
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG----HLEIVKLLLEHADVN---LKDNGRTALHYAARSG 72

                           90
                   ....*....|....*....
gi 568926093   305 FAETVKVFLQHPSVKDDSD 323
Cdd:pfam12796   73 HLEIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 215-455 6.51e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.03  E-value: 6.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  215 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGTfgrhAQIVHLLLERNKSGTIPSDSQGA 294
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGD----VKAVEELLDLGKFADDVFYKDGM 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  295 TPLHYAAQSNfaetvkvflqhpsvkddsdlegrtsfmwaagkgNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHV 374
Cdd:PHA02875  104 TPLHLATILK---------------------------------KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  375 STVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINP 453
Cdd:PHA02875  149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228


                  ..
gi 568926093  454 NV 455
Cdd:PHA02875  229 NI 230
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-238 1.09e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 74.68  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVD--CADALLKAGADVNKTDHSRRTALH--LAAQKGN 93
Cdd:PHA03095   87 LHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAvlLKSRNAN 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   94 YRFMKLLLTRRANWMQKDLEEMTPLH---LSTRHRSPKCLALLLKFMAPGEVDTQDknkQTALHWSAYYNNPEHAKL--L 168
Cdd:PHA03095  167 VELLRLLIDAGADVYAVDDRFRSLLHhhlQSFKPRARIVRELIRAGCDPAATDMLG---NTPLHSMATGSSCKRSLVlpL 243

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926093  169 IKHDSNIGIPDVEGKIPLHWAANHKDPSAVhtVRCI-LDAAPtesllNWQDYEGRTPLHFAVADGNLTVVD 238
Cdd:PHA03095  244 LIAGISINARNRYGQTPLHYAAVFNNPRAC--RRLIaLGADI-----NAVSSDGNTPLSLMVRNNNGRAVR 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 228-502 3.58e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  228 AVADGNLTVVD-VLTSYESCNITSYDNLfrTPLHWAALLgtfgRHAQIVHLLLernKSGTIPSDSQGA--TPLHYAAQSN 304
Cdd:PHA02875    9 AILFGELDIARrLLDIGINPNFEIYDGI--SPIKLAMKF----RDSEAIKLLM---KHGAIPDVKYPDieSELHDAVEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  305 FAETVKVFLQHPSVKDDSDL-EGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVKLLLDN 383
Cdd:PHA02875   80 DVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  384 DAQVDATDVMKHTPLFracemghrdviqtlikggarvdlvdqdghsllhWAALGGNADVCQILIENKINPNvqdYAGRTP 463
Cdd:PHA02875  158 KACLDIEDCCGCTPLI---------------------------------IAMAKGDIAICKMLLDSGANID---YFGKNG 201

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 568926093  464 ---LQCAAY-GGYINCMAVLMENNADPNIQ---DKEGRTALHWSCN 502
Cdd:PHA02875  202 cvaALCYAIeNNKIDIVRLFIKRGADCNIMfmiEGEECTILDMICN 247
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 258-537 5.02e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.61  E-value: 5.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  258 PLHWAALlgtfGRHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWaaGKG 337
Cdd:PHA02878   40 PLHQAVE----ARNLDVVKSLLTRGHNVNQP-DHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAF--NNR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  338 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVstVKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKG 416
Cdd:PHA02878  113 NVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  417 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-E 492
Cdd:PHA02878  191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiL 268

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 568926093  493 GRTALHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTPLDYALL 537
Cdd:PHA02878  269 GLTALHSSIKSE--RKLKLLLEYGADINSL--NSYKLTPLSSAVK 309
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 92-481 7.41e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 7.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   92 GNYRFMKLLLTRRANWMQKDLEE-MTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIK 170
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISVDEtTTPLIDAIRSGDAKIVELFIKHGA--DINHINTKIPHPLLTAIKIGAHDIIKLLID 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  171 H--DSNI-GIPDVEGKiplhwaanhkdpsavhTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-C 246
Cdd:PHA02874   90 NgvDTSIlPIPCIEKD----------------MIKTILDCGID---VNIKDAELKTFLHYAIKKGDLESIKMLFEYGAdV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  247 NItsydnlfrtplhwaallgtfgrhaqivhlllernksgtipSDSQGATPLHYAAQSNFAETVKVFLQHPSVkddsdleg 326
Cdd:PHA02874  151 NI----------------------------------------EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-------- 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  327 rtsfmwaagkgnddvlrtmlslksdidINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACeMGH 406
Cdd:PHA02874  183 ---------------------------ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHN 234

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093  407 RDVIQTLIKgGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGYINCMAVLME 481
Cdd:PHA02874  235 RSAIELLIN-NASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF--KYINKDPVIKD 307
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 224-497 3.37e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  224 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAA----LLGtfgrhaqIVHLLLERNKSGTIPSDSQGATPLHY 299
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICkepnKLG-------MKEMIRSINKCSVFYTLVAIKDAFNN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  300 aaqsNFAETVKVFL--QHPSVKDDSDLEGRTsfmwaagKGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGH 373
Cdd:PHA02878  112 ----RNVEIFKIILtnRYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKD 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  374 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKIN 452
Cdd:PHA02878  181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVD 260

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 568926093  453 PNVQDYA-GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 497
Cdd:PHA02878  261 VNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
Ank_2 pfam12796
Ankyrin repeats (3 copies);
186-282 4.48e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 4.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   186 LHWAANHKDPSAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 264
Cdd:pfam12796    1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70

                           90
                   ....*....|....*...
gi 568926093   265 LGtfgrHAQIVHLLLERN 282
Cdd:pfam12796   71 SG----HLEIVKLLLEKG 84
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 67-229 1.79e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   67 LLKAGADVNKTD-HSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQ 145
Cdd:PHA02878  153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA--STDAR 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  146 DKNKQTALHWS-AYYNNPEHAKLLIKHDSNIGIPD-VEGKIPLHWAANHKDpsavhTVRCILDAAPTESLLNWqdyEGRT 223
Cdd:PHA02878  231 DKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSyILGLTALHSSIKSER-----KLKLLLEYGADINSLNS---YKLT 302


                  ....*.
gi 568926093  224 PLHFAV 229
Cdd:PHA02878  303 PLSSAV 308
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-205 4.34e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 66.23  E-value: 4.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   49 RTPLMYC-----VLADRVDCADALLKAGADVNKTDHSRRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLS 121
Cdd:PHA03100   69 STPLHYLsnikyNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLY 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  122 TRHRSPKC------------------LALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGK 183
Cdd:PHA03100  149 LESNKIDLkilkllidkgvdinaknrVNYLLSYGVP--INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568926093  184 IPLHWAA--NHKD---------PSAVHTVRCIL 205
Cdd:PHA03100  227 TPLHIAIlnNNKEifklllnngPSIKTIIETLL 259
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 617-890 4.73e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 67.50  E-value: 4.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  617 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 696
Cdd:PHA03307  176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  697 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 775
Cdd:PHA03307  254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  776 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 841
Cdd:PHA03307  329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  842 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 890
Cdd:PHA03307  407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 61-359 6.34e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 6.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   61 VDCADALLKAGADVNKTDHSRRTA-------LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHrsPKCLAll 133
Cdd:PHA02878   10 TDNYETILKYIEYIDHTENYSTSAslipfipLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKE--PNKLG-- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLI--KHDSNIGIPDVEGKiplhwAANHKDPSAVHTVRCILDAAPTE 211
Cdd:PHA02878   86 MKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILtnRYKNIQTIDLVYID-----KKSKDDIIEAEITKLLLSYGADI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  212 SLLNwqDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtfgRHAQ--IVHLLLeRNKSGTIPS 289
Cdd:PHA02878  161 NMKD--RHKGNTALHYATENKDQRLTELLLSY-GANVNIPDKTNNSPLHHAV------KHYNkpIVHILL-ENGASTDAR 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926093  290 DSQGATPLHYAAQSNFA-ETVKVFLQH-PSVKDDSDLEGRTSFMWAAgkGNDDVLRTMLSLKSDIDINMSDK 359
Cdd:PHA02878  231 DKCGNTPLHISVGYCKDyDILKLLLEHgVDVNAKSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYK 300
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 302-485 1.83e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 65.27  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  302 QSNFAETVKVFLQH--------------PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHA 367
Cdd:PLN03192  487 QEDNVVILKNFLQHhkelhdlnvgdllgDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHI 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  368 AALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILI 447
Cdd:PLN03192  565 AASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELL 642

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568926093  448 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 485
Cdd:PLN03192  643 KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
PHA02798 PHA02798
ankyrin-like protein; Provisional
 374-533 1.91e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 64.47  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  374 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 443
Cdd:PHA02798   18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  444 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 517
Cdd:PHA02798   93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172

                         170
                  ....*....|....*.
gi 568926093  518 FPNQMeNNEERYTPLD 533
Cdd:PHA02798  173 DINTH-NNKEKYDTLH 187
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 278-481 3.42e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.12  E-value: 3.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  278 LLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSfMW------------------------- 332
Cdd:PLN03192  544 LLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifrilyhfasisdpha 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  333 -------AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPLFRAC 402
Cdd:PLN03192  622 agdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdDDFSPTELRELL 699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  403 ---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTPLQCAAYGGYINC 475
Cdd:PLN03192  700 qkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNERCCNEAGKLINL 769


                  ....*.
gi 568926093  476 MAVLME 481
Cdd:PLN03192  770 PPSLEE 775
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 16-175 3.80e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   16 SQVHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYR 95
Cdd:PHA02875   70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   96 FMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNN-PEHAKLLIKH--D 172
Cdd:PHA02875  150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA--NIDYFGKNGCVAALCYAIENNkIDIVRLFIKRgaD 227


                  ...
gi 568926093  173 SNI 175
Cdd:PHA02875  228 CNI 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
427-479 3.98e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.13  E-value: 3.98e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568926093   427 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 479
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
361-414 5.50e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 5.50e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568926093   361 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 414
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
326-381 8.22e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 8.22e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093   326 GRTSFMWAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 381
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
460-513 1.24e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 1.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568926093   460 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
48-101 1.78e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568926093    48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLL 101
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 339-562 5.28e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 5.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  339 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 418
Cdd:PHA02876  156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  419 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 468
Cdd:PHA02876  236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  469 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 546
Cdd:PHA02876  316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393

                         250
                  ....*....|....*.
gi 568926093  547 MLEHGALSIAAIQDIA 562
Cdd:PHA02876  394 LLDYGADIEALSQKIG 409
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-248 5.60e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.62  E-value: 5.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   48 GRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTrrANWMQKDL---EEMTPLHLSTRH 124
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD--LGKFADDVfykDGMTPLHLATIL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  125 RSPKCLALLLKFMAPGEVDTQDKNkqTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCI 204
Cdd:PHA02875  113 KKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD---IAICKML 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568926093  205 LDAAPTesllnwQDYEGRTP----LHFAVADGNLTVVDVLTSYES-CNI 248
Cdd:PHA02875  188 LDSGAN------IDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdCNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-243 5.91e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 5.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   34 IVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQ-----KGNYRFMKLLLTRRANWM 108
Cdd:PHA03100   21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVN 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  109 QKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgevDTQDKNK--QTALHWSAYYNNPE------------------HAK 166
Cdd:PHA03100  101 APDNNGITPLLyaISKKSNSYSIVEYLLDNGA----NVNIKNSdgENLLHLYLESNKIDlkilkllidkgvdinaknRVN 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926093  167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSavhTVRCILD--AAPtesllNWQDYEGRTPLHFAVADGNLTVVDVLTSY 243
Cdd:PHA03100  177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPE---FVKYLLDlgANP-----NLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 430-513 6.19e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 6.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  430 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 509
Cdd:PTZ00322   86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164


                  ....
gi 568926093  510 KLLL 513
Cdd:PTZ00322  165 QLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 364-552 7.15e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  364 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 442
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  443 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 522
Cdd:PHA02875   85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 568926093  523 ENNEErYTPLDYALLGERHEVIQFMLEHGA 552
Cdd:PHA02875  164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 478-550 7.74e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 7.74e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926093  478 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 550
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 295-501 8.26e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 8.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  295 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 365
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  366 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 428
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  429 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 498
Cdd:cd22192   171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239


                  ...
gi 568926093  499 WSC 501
Cdd:cd22192   240 WTY 242
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 222-404 3.18e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  222 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHwaalLGTFGRHAQIVHLLLERNKSGTIPSDSQgATPL 297
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLH----LATILKKLDIMKLLIARGADPDIPNTDK-FSPL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  298 HYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSlkSDIDINMSDKYGGTALHAAALSGH-VST 376
Cdd:PHA02875  140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDI 217

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568926093  377 VKLLLDNDAQVD-ATDVM--KHTPLFRACEM 404
Cdd:PHA02875  218 VRLFIKRGADCNiMFMIEgeECTILDMICNM 248
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 296-552 7.60e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.04  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  296 PLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHaaalSGHVS 375
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  376 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 449
Cdd:PHA02878  116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  450 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 529
Cdd:PHA02878  191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245

                         250       260
                  ....*....|....*....|...
gi 568926093  530 tpLDYallgerhEVIQFMLEHGA 552
Cdd:PHA02878  246 --KDY-------DILKLLLEHGV 259
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 434-520 8.81e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 8.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  434 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 513
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611


                  ....*..
gi 568926093  514 DFAAFPN 520
Cdd:PLN03192  612 HFASISD 618
Ank_4 pfam13637
Ankyrin repeats (many copies);
396-447 1.22e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 1.22e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568926093   396 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 447
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
446-498 6.88e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 6.88e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568926093   446 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 498
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 369-446 2.27e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 2.27e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926093  369 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 446
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
483-535 2.46e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.46e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568926093   483 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 535
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
67-120 2.83e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.83e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568926093    67 LLKAG-ADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 150-338 2.94e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  150 QTALHWSAYYNNPEHAKLLikhdsnigipdvegkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPL 225
Cdd:cd22192    52 ETALHVAALYDNLEAAVVL------------------------------------MEAAPE--LVNEpmtsDLYQGETAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  226 HFAVADGNLTVVDVLTSYESCNIT----------SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQ 292
Cdd:cd22192    94 HIAVVNQNLNLVRELIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSL 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093  293 GATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSDLE------GRTSFMWAAGKGN 338
Cdd:cd22192   169 GNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQPLDlvpnnqGLTPFKLAAKEGN 224
Ank_5 pfam13857
Ankyrin repeats (many copies);
416-467 3.31e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 3.31e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568926093   416 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 467
Cdd:pfam13857    5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 348-415 3.33e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 3.33e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926093  348 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 415
Cdd:PTZ00322  102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_4 pfam13637
Ankyrin repeats (many copies);
493-548 4.39e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 4.39e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093   493 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 548
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 32-186 7.62e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 7.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   32 RLIVGNSALRDKEDR-FGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQK 110
Cdd:PHA02878  151 KLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568926093  111 DLEEMTPLHLST-RHRSPKCLALLLKFMAPGEVDTQDKNkQTALHWSayYNNPEHAKLLIKHDSNIGIPDVEGKIPL 186
Cdd:PHA02878  231 DKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYILG-LTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPL 304
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 239-327 7.70e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 7.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  239 VLTSYESCNITSYDNlfRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPsv 318
Cdd:PTZ00322  101 LLTGGADPNCRDYDG--RTPLHIACANG----HVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS-- 171


                  ....*....
gi 568926093  319 KDDSDLEGR 327
Cdd:PTZ00322  172 QCHFELGAN 180
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 21-236 9.09e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.63  E-value: 9.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   21 AAVNGDKGALQRLIVGNSAlrDKEDR--FGRTPLMYCVLADRVDCADALLKAGAD-VNKTDHSR----RTALHLAAQKGN 93
Cdd:cd22192    24 AAKENDVQAIKKLLKCPSC--DLFQRgaLGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAVVNQN 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   94 YRFMKLLLTRRAnwmqkdlEEMTPLHLSTR-HRSPKClalLLKFmapGEvdtqdknkqTALHWSAYYNNPEHAKLLIKHD 172
Cdd:cd22192   102 LNLVRELIARGA-------DVVSPRATGTFfRPGPKN---LIYY---GE---------HPLSFAACVGNEEIVRLLIEHG 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926093  173 SNIGIPDVEGKIPLH---WAANHKdpSAVHTVRCIL------DAAPTESLLNwqdYEGRTPLHFAVADGNLTV 236
Cdd:cd22192   160 ADIRAQDSLGNTVLHilvLQPNKT--FACQMYDLILsydkedDLQPLDLVPN---NQGLTPFKLAAKEGNIVM 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 13-153 1.02e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   13 SLASQVHAAAVNGDKgALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQK- 91
Cdd:PHA02878  167 KGNTALHYATENKDQ-RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYc 245

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568926093   92 GNYRFMKLLLTRRANW-MQKDLEEMTPLHLSTrhRSPKCLALLLKFMApgEVDTQDKNKQTAL 153
Cdd:PHA02878  246 KDYDILKLLLEHGVDVnAKSYILGLTALHSSI--KSERKLKLLLEYGA--DINSLNSYKLTPL 304
Ank_4 pfam13637
Ankyrin repeats (many copies);
81-134 1.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 1.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568926093    81 RRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLL 134
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
139-189 2.18e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 2.18e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568926093   139 PGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 189
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03378 PHA03378
EBNA-3B; Provisional
 616-880 2.60e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.52  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  616 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 695
Cdd:PHA03378  575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  696 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHRRCEEGPSSARQPLC--TGSGRPAEKGEDSSPAV 772
Cdd:PHA03378  652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQPPPRAPTPMRPPAAppGRAQRPAAATGRARPPA 728

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  773 ASASQQDHP-------RKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 826
Cdd:PHA03378  729 AAPGRARPPaaapgraRPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568926093  827 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 880
Cdd:PHA03378  809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 410-480 5.48e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 5.48e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926093  410 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 480
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 911-936 5.49e-05

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 41.37  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*.
gi 568926093  911 RKELFRRKNKAAAVIQRAWRSYQLRK 936
Cdd:cd23767     1 EEEELQRMNRAATLIQALWRGYKVRK 26
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 393-552 8.05e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  393 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 472
Cdd:PHA02875    1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  473 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 551
Cdd:PHA02875   81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158


                  .
gi 568926093  552 A 552
Cdd:PHA02875  159 A 159
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-391 1.40e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568926093   360 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 391
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 48-76 2.15e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.15e-04
                            10        20
                    ....*....|....*....|....*....
gi 568926093     48 GRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 48-79 2.50e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 2.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568926093    48 GRTPLMYCVL-ADRVDCADALLKAGADVNKTDH 79
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
351-398 2.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 2.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568926093   351 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 398
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
256-313 3.38e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.38e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568926093   256 RTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFL 313
Cdd:pfam13637    2 LTALHAAAASG----HLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
PHA02791 PHA02791
ankyrin-like protein; Provisional
 218-415 3.60e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.88  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  218 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLgtfgRHAQIVHLLLernKSGTIPS--DSQG 293
Cdd:PHA02791   27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATL----EDTKIVKILL---FSGMDDSqfDDKG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  294 ATPLHYAAQSNFAETVKVFLQHP-SVKDDSDLEGRTSFMWAAGKGNDDVLRTMLS-LKSDIDINMSDkyggTALHAAALS 371
Cdd:PHA02791   95 NTALYYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKN 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 568926093  372 GHVSTVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 415
Cdd:PHA02791  171 GHVDMMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 426-455 3.96e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 3.96e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 568926093    426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
221-279 4.50e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568926093   221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 279
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 557-583 6.67e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 6.67e-04
                          10        20
                  ....*....|....*....|....*..
gi 568926093  557 AIQDIAAFKIQAVYKGYKVRKAFRDRK 583
Cdd:cd23767     6 QRMNRAATLIQALWRGYKVRKELKKKK 32
Ank_5 pfam13857
Ankyrin repeats (many copies);
33-88 6.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 6.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093    33 LIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLA 88
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 228-481 6.81e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 6.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   228 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 306
Cdd:TIGR00870   24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   307 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 385
Cdd:TIGR00870   95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   386 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 442
Cdd:TIGR00870  153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568926093   443 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 481
Cdd:TIGR00870  230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 492-520 7.80e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 7.80e-04
                            10        20
                    ....*....|....*....|....*....
gi 568926093    492 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 520
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
320-368 7.81e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 7.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568926093   320 DDSDLEGRTSFMWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAA 368
Cdd:pfam13857   10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 426-457 1.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568926093   426 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 457
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 426-455 1.15e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568926093   426 DGHSLLHWAALGGNADVCQILIENKINPNV 455
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 460-491 1.29e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.29e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568926093   460 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 491
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 460-488 1.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.45e-03
                            10        20
                    ....*....|....*....|....*....
gi 568926093    460 GRTPLQCAAYGGYINCMAVLMENNADPNI 488
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 642-885 1.93e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  642 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 721
Cdd:PHA03307   12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  722 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 801
Cdd:PHA03307   86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  802 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 872
Cdd:PHA03307  164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                         250
                  ....*....|...
gi 568926093  873 ICASPETGVAHGP 885
Cdd:PHA03307  239 SSSSESSGCGWGP 251
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 326-501 2.29e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 41.79  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  326 GRTSFMWAAGKGNDDVLRTML----------SLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 390
Cdd:cd21882    26 GKTCLHKAALNLNDGVNEAIMllleaapdsgNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  391 DVMKHTPL-----------FRACeMGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----I 445
Cdd:cd21882   106 RFFRKSPGnlfyfgelplsLAAC-TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllL 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568926093  446 LIENKINPNVQ-----DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 501
Cdd:cd21882   185 SYGAHLDPTQQleeipNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 47-76 2.32e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 2.32e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568926093    47 FGRTPLMYCVLADRVDCADALLKAGADVNK 76
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 559-809 2.40e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  559 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 634
Cdd:PRK12678   21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  635 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 710
Cdd:PRK12678  101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  711 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 790
Cdd:PRK12678  181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255

                         250
                  ....*....|....*....
gi 568926093  791 AARPRGASQKRRThqlRDR 809
Cdd:PRK12678  256 EGRGGRRGRRFRD---RDR 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
151-199 2.47e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568926093   151 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 199
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 363-389 2.49e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.49e-03
                            10        20
                    ....*....|....*....|....*..
gi 568926093    363 TALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-175 2.61e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.61e-03
                            10        20
                    ....*....|....*....|....*...
gi 568926093    148 NKQTALHWSAYYNNPEHAKLLIKHDSNI 175
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 150-349 2.70e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   150 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAPTES----LLNWQD----Y 219
Cdd:TIGR00870   53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAFRKSgpleLANDQYtsefT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   220 EGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTfgrhAQIVHLLLErNKSGT 286
Cdd:TIGR00870  127 PGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS----PSIVALLSE-DPADI 201

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926093   287 IPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGKGNDDVLRTMLSLK 349
Cdd:TIGR00870  202 LTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKEGRIVLFRLKLAIK 280
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-389 3.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 3.25e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568926093   360 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 389
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
185-240 3.26e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 3.26e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093   185 PLHWAANHKDPSAVHtvRCILDAAPteslLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:pfam13637    4 ALHAAAASGHLELLR--LLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 409-585 3.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  409 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 488
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093  489 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 567
Cdd:PHA02876  240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306

                         170
                  ....*....|....*...
gi 568926093  568 AVYKGYKVRKAFRDRKNL 585
Cdd:PHA02876  307 GETPLYLMAKNGYDTENI 324
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 82-106 3.69e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.69e-03
                            10        20
                    ....*....|....*....|....*
gi 568926093     82 RTALHLAAQKGNYRFMKLLLTRRAN 106
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGAD 27
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-169 3.74e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 3.74e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568926093   114 EMTPLHLSTRHRSPKCLALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGAD--INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
213-262 4.09e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 4.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568926093   213 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 262
Cdd:pfam13857    8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 45-106 4.91e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 4.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926093   45 DRFGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRAN 106
Cdd:PHA03100  189 DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 55-135 5.16e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926093   55 CVLADRVDCADA--LLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLAL 132
Cdd:PTZ00322   87 CQLAASGDAVGAriLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ...
gi 568926093  133 LLK 135
Cdd:PTZ00322  167 LSR 169
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 50-123 6.54e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.97  E-value: 6.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568926093   50 TPLMYCVLADRVDCADALLKAGADVNK-TDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTR 123
Cdd:PHA02884   72 NPLIYAIDCDNDDAAKLLIRYGADVNRyAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
C11orf65 cd21090
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ...
 918-964 7.54e-03

chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.


Pssm-ID: 411042  Cd Length: 260  Bit Score: 39.61  E-value: 7.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568926093  918 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 964
Cdd:cd21090     4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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