guanylate binding protein 8 isoform X1 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
GBP_C | pfam02841 | Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ... |
206-493 | 1.19e-148 | |||||
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP. : Pssm-ID: 397124 [Multi-domain] Cd Length: 297 Bit Score: 427.47 E-value: 1.19e-148
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P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
16-207 | 7.44e-110 | |||||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member pfam02263: Pssm-ID: 453896 Cd Length: 260 Bit Score: 327.41 E-value: 7.44e-110
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Name | Accession | Description | Interval | E-value | |||||
GBP_C | pfam02841 | Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ... |
206-493 | 1.19e-148 | |||||
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP. Pssm-ID: 397124 [Multi-domain] Cd Length: 297 Bit Score: 427.47 E-value: 1.19e-148
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GBP_C | cd16269 | Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
206-493 | 8.74e-141 | |||||
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines. Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 407.35 E-value: 8.74e-141
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GBP | pfam02263 | Guanylate-binding protein, N-terminal domain; Transcription of the anti-viral ... |
16-207 | 7.44e-110 | |||||
Guanylate-binding protein, N-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP. Pssm-ID: 426686 Cd Length: 260 Bit Score: 327.41 E-value: 7.44e-110
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GBP | cd01851 | Guanylate-binding protein (GBP) family (N-terminal domain); Guanylate-binding protein (GBP), ... |
30-217 | 1.26e-59 | |||||
Guanylate-binding protein (GBP) family (N-terminal domain); Guanylate-binding protein (GBP), N-terminal domain. Guanylate-binding proteins (GBPs) define a group of proteins that are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. Furthermore, two unique regions around the base and the phosphate-binding areas, the guanine and the phosphate caps, respectively, give the nucleotide-binding site a unique appearance not found in the canonical GTP-binding proteins. The phosphate cap, which constitutes the region analogous to switch I, completely shields the phosphate-binding site from solvent such that a potential GTPase-activating protein (GAP) cannot approach. Pssm-ID: 206650 Cd Length: 224 Bit Score: 196.39 E-value: 1.26e-59
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
403-503 | 3.56e-07 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 52.50 E-value: 3.56e-07
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TolA | COG3064 | Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
369-491 | 2.82e-05 | |||||
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 225606 [Multi-domain] Cd Length: 387 Bit Score: 46.48 E-value: 2.82e-05
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tolA_full | TIGR02794 | TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ... |
359-503 | 3.69e-04 | |||||
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis] Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 42.91 E-value: 3.69e-04
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YeeP | COG3596 | Predicted GTPase [General function prediction only]; |
23-108 | 7.91e-03 | |||||
Predicted GTPase [General function prediction only]; Pssm-ID: 226124 [Multi-domain] Cd Length: 296 Bit Score: 38.23 E-value: 7.91e-03
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Name | Accession | Description | Interval | E-value | |||||
GBP_C | pfam02841 | Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ... |
206-493 | 1.19e-148 | |||||
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP. Pssm-ID: 397124 [Multi-domain] Cd Length: 297 Bit Score: 427.47 E-value: 1.19e-148
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GBP_C | cd16269 | Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
206-493 | 8.74e-141 | |||||
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines. Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 407.35 E-value: 8.74e-141
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GBP | pfam02263 | Guanylate-binding protein, N-terminal domain; Transcription of the anti-viral ... |
16-207 | 7.44e-110 | |||||
Guanylate-binding protein, N-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP. Pssm-ID: 426686 Cd Length: 260 Bit Score: 327.41 E-value: 7.44e-110
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GBP | cd01851 | Guanylate-binding protein (GBP) family (N-terminal domain); Guanylate-binding protein (GBP), ... |
30-217 | 1.26e-59 | |||||
Guanylate-binding protein (GBP) family (N-terminal domain); Guanylate-binding protein (GBP), N-terminal domain. Guanylate-binding proteins (GBPs) define a group of proteins that are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. Furthermore, two unique regions around the base and the phosphate-binding areas, the guanine and the phosphate caps, respectively, give the nucleotide-binding site a unique appearance not found in the canonical GTP-binding proteins. The phosphate cap, which constitutes the region analogous to switch I, completely shields the phosphate-binding site from solvent such that a potential GTPase-activating protein (GAP) cannot approach. Pssm-ID: 206650 Cd Length: 224 Bit Score: 196.39 E-value: 1.26e-59
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Ras_like_GTPase | cd00882 | Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
40-115 | 1.16e-08 | |||||
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions. Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 54.38 E-value: 1.16e-08
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DUF5401 | pfam17380 | Family of unknown function (DUF5401); This is a family of unknown function found in ... |
405-501 | 1.60e-07 | |||||
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea. Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 53.97 E-value: 1.60e-07
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
403-503 | 3.56e-07 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 52.50 E-value: 3.56e-07
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DUF3584 | pfam12128 | Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
227-497 | 2.43e-06 | |||||
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication. Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 50.61 E-value: 2.43e-06
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
369-502 | 4.25e-06 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 49.75 E-value: 4.25e-06
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MAP7 | pfam05672 | MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is ... |
404-491 | 8.34e-06 | |||||
MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent. Pssm-ID: 428577 [Multi-domain] Cd Length: 153 Bit Score: 45.78 E-value: 8.34e-06
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
368-503 | 9.25e-06 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.60 E-value: 9.25e-06
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
401-484 | 1.01e-05 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 47.88 E-value: 1.01e-05
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
400-502 | 1.31e-05 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.21 E-value: 1.31e-05
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PRK12704 | PRK12704 | phosphodiesterase; Provisional |
409-503 | 1.46e-05 | |||||
phosphodiesterase; Provisional Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 47.47 E-value: 1.46e-05
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
353-503 | 1.76e-05 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 1.76e-05
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
399-498 | 2.12e-05 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.44 E-value: 2.12e-05
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DUF4200 | pfam13863 | Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ... |
414-502 | 2.18e-05 | |||||
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function. Pssm-ID: 433535 [Multi-domain] Cd Length: 119 Bit Score: 43.72 E-value: 2.18e-05
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TolA | COG3064 | Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
369-491 | 2.82e-05 | |||||
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 225606 [Multi-domain] Cd Length: 387 Bit Score: 46.48 E-value: 2.82e-05
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
390-502 | 8.18e-05 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 8.18e-05
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DUF5401 | pfam17380 | Family of unknown function (DUF5401); This is a family of unknown function found in ... |
399-505 | 8.81e-05 | |||||
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea. Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 45.11 E-value: 8.81e-05
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TolA | COG3064 | Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
404-484 | 9.13e-05 | |||||
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 225606 [Multi-domain] Cd Length: 387 Bit Score: 44.94 E-value: 9.13e-05
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Smc | COG1196 | Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; |
384-503 | 9.16e-05 | |||||
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 224117 [Multi-domain] Cd Length: 1163 Bit Score: 45.48 E-value: 9.16e-05
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
390-502 | 9.38e-05 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 9.38e-05
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EnvC | COG4942 | Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
209-486 | 1.38e-04 | |||||
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227278 [Multi-domain] Cd Length: 420 Bit Score: 44.33 E-value: 1.38e-04
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PRK12704 | PRK12704 | phosphodiesterase; Provisional |
379-485 | 2.21e-04 | |||||
phosphodiesterase; Provisional Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 43.61 E-value: 2.21e-04
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TolA | COG3064 | Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
378-502 | 2.25e-04 | |||||
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 225606 [Multi-domain] Cd Length: 387 Bit Score: 43.40 E-value: 2.25e-04
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Smc | COG1196 | Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; |
384-502 | 3.55e-04 | |||||
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 224117 [Multi-domain] Cd Length: 1163 Bit Score: 43.55 E-value: 3.55e-04
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tolA_full | TIGR02794 | TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ... |
359-503 | 3.69e-04 | |||||
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis] Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 42.91 E-value: 3.69e-04
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
390-502 | 4.36e-04 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.21 E-value: 4.36e-04
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CAF-1_p150 | pfam11600 | Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ... |
399-484 | 4.99e-04 | |||||
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis. Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 40.83 E-value: 4.99e-04
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
400-502 | 5.04e-04 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.21 E-value: 5.04e-04
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ATP_synt_b | TIGR01144 | ATP synthase, F0 subunit b; This model describes the F1/F0 ATP synthase b subunit in bacteria ... |
394-476 | 5.08e-04 | |||||
ATP synthase, F0 subunit b; This model describes the F1/F0 ATP synthase b subunit in bacteria only. Scoring just below the trusted cutoff are the N-terminal domains of Mycobacterial b/delta fusion proteins and a subunit from an archaeon, Methanosarcina barkeri, in which the ATP synthase homolog differs in architecture and is not experimentally confirmed. This model helps resolve b from the related b' subunit. Within the family is an example from a sodium-translocating rather than proton-translocating ATP synthase. [Energy metabolism, ATP-proton motive force interconversion] Pssm-ID: 130214 [Multi-domain] Cd Length: 147 Bit Score: 40.46 E-value: 5.08e-04
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SMC_prok_B | TIGR02168 | chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
385-502 | 5.76e-04 | |||||
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 42.74 E-value: 5.76e-04
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CCDC73 | pfam15818 | Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ... |
400-523 | 6.40e-04 | |||||
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79. Pssm-ID: 434960 [Multi-domain] Cd Length: 1050 Bit Score: 42.57 E-value: 6.40e-04
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
411-503 | 6.78e-04 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 42.10 E-value: 6.78e-04
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ERM | pfam00769 | Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ... |
409-503 | 7.85e-04 | |||||
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins. Pssm-ID: 425860 [Multi-domain] Cd Length: 247 Bit Score: 41.08 E-value: 7.85e-04
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Mitofilin | pfam09731 | Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ... |
385-501 | 7.92e-04 | |||||
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains. Pssm-ID: 430783 [Multi-domain] Cd Length: 618 Bit Score: 42.05 E-value: 7.92e-04
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
397-501 | 9.48e-04 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 9.48e-04
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tolA_full | TIGR02794 | TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ... |
399-483 | 1.04e-03 | |||||
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis] Pssm-ID: 274303 [Multi-domain] Cd Length: 346 Bit Score: 41.37 E-value: 1.04e-03
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Smc | COG1196 | Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; |
290-503 | 1.12e-03 | |||||
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 224117 [Multi-domain] Cd Length: 1163 Bit Score: 41.62 E-value: 1.12e-03
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AtpF | COG0711 | FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; |
399-502 | 1.12e-03 | |||||
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; Pssm-ID: 223783 [Multi-domain] Cd Length: 161 Bit Score: 39.59 E-value: 1.12e-03
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DUF5401 | pfam17380 | Family of unknown function (DUF5401); This is a family of unknown function found in ... |
291-503 | 1.13e-03 | |||||
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea. Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 41.65 E-value: 1.13e-03
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SbcC | COG0419 | DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
273-503 | 1.14e-03 | |||||
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; Pssm-ID: 223496 [Multi-domain] Cd Length: 908 Bit Score: 41.67 E-value: 1.14e-03
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Borrelia_P83 | pfam05262 | Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins. |
390-491 | 1.22e-03 | |||||
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins. Pssm-ID: 114011 [Multi-domain] Cd Length: 489 Bit Score: 41.53 E-value: 1.22e-03
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SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
406-503 | 1.39e-03 | |||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 41.59 E-value: 1.39e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
403-502 | 1.44e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.67 E-value: 1.44e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
390-502 | 1.49e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 41.67 E-value: 1.49e-03
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PRK00409 | PRK00409 | recombination and DNA strand exchange inhibitor protein; Reviewed |
383-503 | 1.54e-03 | |||||
recombination and DNA strand exchange inhibitor protein; Reviewed Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 41.35 E-value: 1.54e-03
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
399-503 | 1.55e-03 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 40.95 E-value: 1.55e-03
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SbcC | COG0419 | DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
365-503 | 1.58e-03 | |||||
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; Pssm-ID: 223496 [Multi-domain] Cd Length: 908 Bit Score: 41.28 E-value: 1.58e-03
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PspA | COG1842 | Phage shock protein A [Transcription, Signal transduction mechanisms]; |
379-472 | 1.97e-03 | |||||
Phage shock protein A [Transcription, Signal transduction mechanisms]; Pssm-ID: 224755 [Multi-domain] Cd Length: 225 Bit Score: 39.99 E-value: 1.97e-03
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ARGLU | pfam15346 | Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ... |
404-503 | 2.02e-03 | |||||
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes. Pssm-ID: 405931 [Multi-domain] Cd Length: 151 Bit Score: 38.88 E-value: 2.02e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
397-503 | 2.21e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.89 E-value: 2.21e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
369-502 | 2.24e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.89 E-value: 2.24e-03
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Nup88 | pfam10168 | Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ... |
370-503 | 2.31e-03 | |||||
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumor cells. Pssm-ID: 431106 Cd Length: 713 Bit Score: 40.80 E-value: 2.31e-03
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Mplasa_alph_rch | TIGR04523 | helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
405-503 | 2.45e-03 | |||||
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown. Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 40.77 E-value: 2.45e-03
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TPH | pfam13868 | Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
399-503 | 2.48e-03 | |||||
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain. Pssm-ID: 433539 [Multi-domain] Cd Length: 341 Bit Score: 40.28 E-value: 2.48e-03
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G_path_suppress | pfam15991 | G-protein pathway suppressor; This family of proteins inhibits G-protein- and ... |
405-497 | 2.55e-03 | |||||
G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction. Pssm-ID: 406402 [Multi-domain] Cd Length: 273 Bit Score: 39.91 E-value: 2.55e-03
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TPH | pfam13868 | Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
399-502 | 3.28e-03 | |||||
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain. Pssm-ID: 433539 [Multi-domain] Cd Length: 341 Bit Score: 39.90 E-value: 3.28e-03
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SbcC | COG0419 | DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
369-502 | 3.38e-03 | |||||
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; Pssm-ID: 223496 [Multi-domain] Cd Length: 908 Bit Score: 40.13 E-value: 3.38e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
390-501 | 3.44e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.51 E-value: 3.44e-03
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PRK12704 | PRK12704 | phosphodiesterase; Provisional |
408-485 | 4.38e-03 | |||||
phosphodiesterase; Provisional Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 39.76 E-value: 4.38e-03
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Cast | pfam10174 | RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
392-493 | 4.53e-03 | |||||
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains. Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 39.81 E-value: 4.53e-03
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DUF4207 | pfam13904 | Domain of unknown function (DUF4207); This family is found in eukaryotes; it has several ... |
408-503 | 4.59e-03 | |||||
Domain of unknown function (DUF4207); This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known. Pssm-ID: 433570 [Multi-domain] Cd Length: 223 Bit Score: 38.54 E-value: 4.59e-03
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fliH | PRK06669 | flagellar assembly protein H; Validated |
363-502 | 4.70e-03 | |||||
flagellar assembly protein H; Validated Pssm-ID: 235850 [Multi-domain] Cd Length: 281 Bit Score: 38.84 E-value: 4.70e-03
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Smc | COG1196 | Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; |
400-502 | 4.95e-03 | |||||
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 224117 [Multi-domain] Cd Length: 1163 Bit Score: 39.70 E-value: 4.95e-03
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Utp11 | pfam03998 | Utp11 protein; This protein is found to be part of a large ribonucleoprotein complex ... |
404-481 | 5.26e-03 | |||||
Utp11 protein; This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome. Pssm-ID: 427640 Cd Length: 240 Bit Score: 38.75 E-value: 5.26e-03
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ATP-synt_B | pfam00430 | ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is ... |
379-456 | 5.72e-03 | |||||
ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is thought to translocate protons through membrane (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits. This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in pfam00006 Pssm-ID: 425677 [Multi-domain] Cd Length: 132 Bit Score: 37.29 E-value: 5.72e-03
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sbcc | TIGR00618 | exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
403-503 | 6.26e-03 | |||||
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 39.18 E-value: 6.26e-03
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PRK11637 | PRK11637 | AmiB activator; Provisional |
397-502 | 6.39e-03 | |||||
AmiB activator; Provisional Pssm-ID: 236942 [Multi-domain] Cd Length: 428 Bit Score: 38.91 E-value: 6.39e-03
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CAF-1_p150 | pfam11600 | Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ... |
365-480 | 6.68e-03 | |||||
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis. Pssm-ID: 402959 [Multi-domain] Cd Length: 164 Bit Score: 37.36 E-value: 6.68e-03
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Caldesmon | pfam02029 | Caldesmon; |
375-497 | 6.71e-03 | |||||
Caldesmon; Pssm-ID: 426572 [Multi-domain] Cd Length: 490 Bit Score: 39.08 E-value: 6.71e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
399-501 | 6.80e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 39.35 E-value: 6.80e-03
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Smc | COG1196 | Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; |
383-502 | 7.03e-03 | |||||
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 224117 [Multi-domain] Cd Length: 1163 Bit Score: 39.31 E-value: 7.03e-03
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MAP7 | pfam05672 | MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is ... |
404-491 | 7.62e-03 | |||||
MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent. Pssm-ID: 428577 [Multi-domain] Cd Length: 153 Bit Score: 37.31 E-value: 7.62e-03
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YeeP | COG3596 | Predicted GTPase [General function prediction only]; |
23-108 | 7.91e-03 | |||||
Predicted GTPase [General function prediction only]; Pssm-ID: 226124 [Multi-domain] Cd Length: 296 Bit Score: 38.23 E-value: 7.91e-03
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PTZ00121 | PTZ00121 | MAEBL; Provisional |
374-502 | 8.49e-03 | |||||
MAEBL; Provisional Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 38.97 E-value: 8.49e-03
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UPF0242 | pfam06785 | Uncharacterized protein family (UPF0242); |
385-502 | 9.06e-03 | |||||
Uncharacterized protein family (UPF0242); Pssm-ID: 429117 [Multi-domain] Cd Length: 194 Bit Score: 37.49 E-value: 9.06e-03
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tolA | PRK09510 | cell envelope integrity inner membrane protein TolA; Provisional |
399-502 | 9.38e-03 | |||||
cell envelope integrity inner membrane protein TolA; Provisional Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 38.25 E-value: 9.38e-03
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SbcC | COG0419 | DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
385-503 | 9.80e-03 | |||||
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; Pssm-ID: 223496 [Multi-domain] Cd Length: 908 Bit Score: 38.59 E-value: 9.80e-03
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SMC_prok_A | TIGR02169 | chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
401-500 | 9.95e-03 | |||||
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins] Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 38.90 E-value: 9.95e-03
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Blast search parameters | ||||
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