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Conserved domains on  [gi|568936828|ref|XP_006530210|]
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citron Rho-interacting kinase isoform X19 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1242-1538 1.60e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.60e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1242 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1314
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1315 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1388
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1389 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1464
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936828   1465 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1538
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 993-1048 4.14e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.14e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  993 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-828 1.38e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.38e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKL 451
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   452 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------ 501
Cdd:TIGR02168  580 SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   502 ------TELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLE 575
Cdd:TIGR02168  660 vitggsAKTNSSILERRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELS 725

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   576 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTM 655
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   656 LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEI 734
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNER 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   735 LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFR 806
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENK 962

                          810       820
                   ....*....|....*....|..
gi 568936828   807 LTQGLQEALDRADLLKTERSDL 828
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKEL 984
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1078-1197 8.03e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1078 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1157
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568936828  1158 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1197
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 708-985 2.25e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  708 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 785
Cdd:COG3883    10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  786 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 862
Cdd:COG3883    86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  863 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 942
Cdd:COG3883   141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 568936828  943 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 985
Cdd:COG3883   221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1554-1645 1.35e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1554 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1617
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                          90       100       110
                  ....*....|....*....|....*....|
gi 568936828 1618 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1645
Cdd:PTZ00449  607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 8.48e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883    42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883   122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                         170
                  ....*....|....
gi 568936828  139 YESELRESRLAAEE 152
Cdd:COG3883   201 LEAELAAAEAAAAA 214
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1242-1538 1.60e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.60e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1242 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1314
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1315 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1388
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1389 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1464
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936828   1465 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1538
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1250-1502 4.34e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.60  E-value: 4.34e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1250 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1328
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1329 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1406
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1407 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1486
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 568936828  1487 YLFVTHFNSLEVIEIQ 1502
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 993-1048 4.14e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.14e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  993 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-828 1.38e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.38e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKL 451
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   452 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------ 501
Cdd:TIGR02168  580 SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   502 ------TELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLE 575
Cdd:TIGR02168  660 vitggsAKTNSSILERRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELS 725

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   576 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTM 655
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   656 LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEI 734
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNER 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   735 LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFR 806
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENK 962

                          810       820
                   ....*....|....*....|..
gi 568936828   807 LTQGLQEALDRADLLKTERSDL 828
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 278-847 4.84e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.33  E-value: 4.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  278 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 349
Cdd:COG1196   172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  350 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 429
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  430 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 499
Cdd:COG1196   321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  500 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 579
Cdd:COG1196   401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  580 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 643
Cdd:COG1196   481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  644 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 719
Cdd:COG1196   561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  720 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 799
Cdd:COG1196   641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 568936828  800 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 847
Cdd:COG1196   721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-795 9.40e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 90.03  E-value: 9.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    82 VSQEDDKALQLLHDI--REQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANE 159
Cdd:pfam02463  323 KKKAEKELKKEKEEIeeLEKELKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   160 CQHKLMKVVShpprgdsggtALDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKavKASTEAT 239
Cdd:pfam02463  399 LKSEEEKEAQ----------LLLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEK--QELKLLK 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   240 ELLQNIRQAKERAERELEKLH-NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLkDDIQTKSEQIQQMADKI 318
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQeQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI-ISAHGRLGDLGVAVENY 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:pfam02463  542 KVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRL-LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDK 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 478
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   479 LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 558
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEER 780

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   559 RKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhlrreitEREMQLTSQKQAQL 638
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEE---------LALELKEEQKLEKL 851

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   639 SAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRIT 717
Cdd:pfam02463  852 AEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILL 931

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828   718 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 795
Cdd:pfam02463  932 KYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
206-675 8.38e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 86.66  E-value: 8.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  206 EYSKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLEN 285
Cdd:PRK03918  229 EVKELEELKEE----IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEE 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  286 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDN--QIKKDLAD 363
Cdd:PRK03918  305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-LEERHELYEEAKAKKEEleRLKKRLTG 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  364 K--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISE 436
Cdd:PRK03918  384 LtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKR 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLS 507
Cdd:PRK03918  464 IEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKS 543

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  508 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEE 576
Cdd:PRK03918  544 LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEK 619

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  577 QLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTML 656
Cdd:PRK03918  620 ELKKLEEE----------LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRR 689

                         490
                  ....*....|....*....
gi 568936828  657 EEQVLDLEALNDELLEKER 675
Cdd:PRK03918  690 EEIKKTLEKLKEELEEREK 708
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 997-1045 1.87e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.87e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568936828    997 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1045
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1250-1501 2.30e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1250 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1321
Cdd:COG5422   868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1322 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1390
Cdd:COG5422   944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1391 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1469
Cdd:COG5422  1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                         250       260       270
                  ....*....|....*....|....*....|...
gi 568936828 1470 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1501
Cdd:COG5422  1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1078-1197 8.03e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1078 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1157
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568936828  1158 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1197
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1078-1197 2.96e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.96e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1078 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1157
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 568936828   1158 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1197
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 992-1047 1.99e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.99e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828   992 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1047
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 708-985 2.25e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  708 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 785
Cdd:COG3883    10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  786 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 862
Cdd:COG3883    86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  863 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 942
Cdd:COG3883   141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 568936828  943 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 985
Cdd:COG3883   221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1554-1645 1.35e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1554 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1617
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                          90       100       110
                  ....*....|....*....|....*....|
gi 568936828 1618 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1645
Cdd:PTZ00449  607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1079-1124 7.12e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568936828 1079 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1124
Cdd:cd01242     2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2-377 9.25e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 9.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    2 EKKLLIKSKELQDSQDKchKMEQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARM 80
Cdd:NF033838  112 EAELTSKTKKELDAAFE--QFKKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   81 EVSQEDdkaLQLLHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRLAAEEFKRKANEC 160
Cdd:NF033838  184 EVKKAE---LELVKEEAKEPRDEEKIKQAK--AKVESKKAEATRLEK-IKTDREKAEEEAKRRADAKLKEAVEKNVATSE 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  161 QHKLMKVVShppRGDSGGTALDDlhKMQGHAgltsakDQGKPEVGEYS------KLEKINAEQQLKIQELQEKLEK---- 230
Cdd:NF033838  258 QDKPKRRAK---RGVLGEPATPD--KKENDA------KSSDSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkee 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  231 ------AVKASTEATELLQNIRQAKErAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDI 304
Cdd:NF033838  327 drrnypTNTYKTLELEIAESDVKVKE-AELELVKEEAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDR 395

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828  305 QTKSEQIQQMADKILELEEKHREAQVSAQHLEVhlkQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 377
Cdd:NF033838  396 KKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP---EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 8.48e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883    42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883   122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                         170
                  ....*....|....
gi 568936828  139 YESELRESRLAAEE 152
Cdd:COG3883   201 LEAELAAAEAAAAA 214
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 547-666 2.89e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.59  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  547 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 623
Cdd:cd22656   119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568936828  624 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 666
Cdd:cd22656   196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 220-349 5.37e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 5.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIK----KKLVEA-EERRHSLENKVKRLETME 294
Cdd:smart00787  152 NLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDptelDRAKEKlKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828    295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK 349
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1242-1538 1.60e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.60e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1242 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1314
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1315 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1388
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1389 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1464
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936828   1465 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1538
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1250-1502 4.34e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.60  E-value: 4.34e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1250 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1328
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1329 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1406
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1407 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1486
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 568936828  1487 YLFVTHFNSLEVIEIQ 1502
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 993-1048 4.14e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.14e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  993 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-828 1.38e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.38e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKL 451
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   452 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSL------------EHEEQKLELKRQL------------------ 501
Cdd:TIGR02168  580 SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAKKLrpgyrivtldgdlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   502 ------TELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLE 575
Cdd:TIGR02168  660 vitggsAKTNSSILERRREIEELEEKIEELEEKIAELE--------------KALAELRKELEELEEELEQLRKELEELS 725

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   576 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTM 655
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE-ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   656 LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEI 734
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIESLAAEIEELEELIEEL--ESELEALLNER 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   735 LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFR 806
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGLEVRIDNLQERLseEYSLTLEeaEALENK 962

                          810       820
                   ....*....|....*....|..
gi 568936828   807 LTQGLQEALDRADLLKTERSDL 828
Cdd:TIGR02168  963 IEDDEEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 278-847 4.84e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.33  E-value: 4.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  278 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 349
Cdd:COG1196   172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  350 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 429
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  430 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 499
Cdd:COG1196   321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  500 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 579
Cdd:COG1196   401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  580 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 643
Cdd:COG1196   481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  644 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 719
Cdd:COG1196   561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  720 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 799
Cdd:COG1196   641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 568936828  800 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 847
Cdd:COG1196   721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 215-829 5.99e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.94  E-value: 5.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  215 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtme 294
Cdd:COG1196   209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE--- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRH 374
Cdd:COG1196   281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE----LEEELEELEEELEEAEEELEEA 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  375 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAGKLEAQ 454
Cdd:COG1196   357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL---EELEEALAEL 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  455 NRKLEEQLEKISHQDhSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKt 534
Cdd:COG1196   434 EEEEEEEEEALEEAA-EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK- 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  535 eLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQL 612
Cdd:COG1196   512 -AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRAR 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  613 RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEAlkttctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFE 692
Cdd:COG1196   586 AALAAALARGAIGAAVDLVASDLREADARYYVLGDT-------LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  693 cRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSL 772
Cdd:COG1196   659 -GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREEL 737

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936828  773 QQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-------ALD-------RADLLKTERSDLE 829
Cdd:COG1196   738 LEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 216-928 1.17e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 102.83  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   216 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLHNREDSSEG--IKKKLVEAEERRHSLENKVKRletM 293
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   294 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 370
Cdd:TIGR02168  252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   371 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 450
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 530
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   531 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 610
Cdd:TIGR02168  472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   611 QLRSEvdhLRREITE-----REMQLTSQKQAQLSAPDLQTmEALKTTCTMLEEQVL---DLEALNDELLEKERQWEAWRS 682
Cdd:TIGR02168  530 SVDEG---YEAAIEAalggrLQAVVVENLNAAKKAIAFLK-QNELGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAK 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   683 VLGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQ 744
Cdd:TIGR02168  606 DLVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEEL 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   745 KLKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE 824
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   825 RSDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKA 904
Cdd:TIGR02168  756 LTELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831

                          730       740
                   ....*....|....*....|....
gi 568936828   905 RCAELEEALQKTRIELRSAREEAA 928
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIE 855
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 10-778 5.59e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.89  E-value: 5.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKA 89
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    90 LQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKV 167
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEElaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   168 VSHPPRGDSGGTALDDLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQ 247
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELRE 468

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   248 AKERAERELEKLHNREDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ--------------- 312
Cdd:TIGR02168  469 ELEEAEQALDAAERELAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalgg 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   313 ----------QMADKILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM--- 371
Cdd:TIGR02168  546 rlqavvvenlNAAKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggv 625

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   372 -----------QRHEEEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMIS 435
Cdd:TIGR02168  626 lvvddldnaleLAKKLRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIA 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   436 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERE 512
Cdd:TIGR02168  695 ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAE 774

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   513 SQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDN 585
Cdd:TIGR02168  775 EELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDI 854

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   586 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEA 665
Cdd:TIGR02168  855 ESLAAEIEELEELIEELESELEALLNERASLEEALALL-RSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG 933

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   666 LNDELLE-KERQWEAWRSVLGDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAVKEHKaEILALQQALKEQ 744
Cdd:TIGR02168  934 LEVRIDNlQERLSEEYSLTLEEAEALENKIEDDEEEA----RRRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTAQ 1008

                          810       820       830
                   ....*....|....*....|....*....|....
gi 568936828   745 KlkaESLSDKLNDLEKkhAMLEMNARSLQQKLET 778
Cdd:TIGR02168 1009 K---EDLTEAKETLEE--AIEEIDREARERFKDT 1037
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-795 9.40e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 90.03  E-value: 9.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    82 VSQEDDKALQLLHDI--REQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANE 159
Cdd:pfam02463  323 KKKAEKELKKEKEEIeeLEKELKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   160 CQHKLMKVVShpprgdsggtALDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKavKASTEAT 239
Cdd:pfam02463  399 LKSEEEKEAQ----------LLLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEK--QELKLLK 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   240 ELLQNIRQAKERAERELEKLH-NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLkDDIQTKSEQIQQMADKI 318
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQeQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI-ISAHGRLGDLGVAVENY 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:pfam02463  542 KVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRL-LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDK 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 478
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   479 LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 558
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEER 780

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   559 RKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhlrreitEREMQLTSQKQAQL 638
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEE---------LALELKEEQKLEKL 851

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   639 SAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRIT 717
Cdd:pfam02463  852 AEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILL 931

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828   718 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 795
Cdd:pfam02463  932 KYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 70-623 3.22e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.07  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   70 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 149
Cdd:COG1196   204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  150 AEEFKRKANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEvgeyskLEKINAEQQLKIQELQEKLE 229
Cdd:COG1196   276 LEELELELEEAQAEEYELLAELAR-----LEQDIARLEERRRELEERLEELEEE------LAELEEELEELEEELEELEE 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  230 KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETME----RRENRLKDDIQ 305
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEeallERLERLEEELE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  306 TKSEQIQQMADKILELEEKHREAQ----------VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE 375
Cdd:COG1196   425 ELEEALAELEEEEEEEEEALEEAAeeeaeleeeeEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  376 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK-----FYLETQAGK 450
Cdd:COG1196   505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagratFLPLDKIRA 584

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  451 LEAQNRKLEEQLEK-----------------------------ISHQDHSDKSRLLELETRLREVSLEHEEQkleLKRQL 501
Cdd:COG1196   585 RAALAAALARGAIGaavdlvasdlreadaryyvlgdtllgrtlVAARLEAALRRAVTLAGRLREVTLEGEGG---SAGGS 661

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  502 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 581
Cdd:COG1196   662 LTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 568936828  582 TEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREI 623
Cdd:COG1196   742 LEEEEL-------LEEEALEELPEPPDLEELERELERLEREI 776
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 208-760 3.47e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.07  E-value: 3.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  208 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:COG1196   267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESL 367
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAnsslftQRNMKAQEEMISELRQQKFYLETQ 447
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE------AALAELLEELAEAAARLLLLLEAE 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  448 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEqkLELKRQLTELQLSLQERESQLTALQAARAA--- 524
Cdd:COG1196   501 ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATflp 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  525 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 604
Cdd:COG1196   579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  605 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSApdlqtmealkttctmLEEQVLDLEALNDELLEKERQWEAWRSVL 684
Cdd:COG1196   659 GGSLTGGSRRELLAALLEAEAELEELAERLAEEELE---------------LEEALLAEEEEERELAEAEEERLEEELEE 723

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  685 GDEKSQFE-CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI--------LALQQaLKEQKLKAESLSD 753
Cdd:COG1196   724 EALEEQLEaEREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgpvnlLAIEE-YEELEERYDFLSE 802


                  ....*..
gi 568936828  754 KLNDLEK 760
Cdd:COG1196   803 QREDLEE 809
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-626 5.49e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.42  E-value: 5.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    82 VSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQ 161
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ 488

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   162 HKLMKVVS----HPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvgeYSK------------LEKINAEQQLKIQELQ 225
Cdd:TIGR02168  489 ARLDSLERlqenLEGFSEGVKALLKNQSGLSGILGVLSELISVDEG---YEAaieaalggrlqaVVVENLNAAKKAIAFL 565

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   226 EKLEKA------------------------------------VKASTEATELLQN--------------IRQAKE----- 250
Cdd:TIGR02168  566 KQNELGrvtflpldsikgteiqgndreilkniegflgvakdlVKFDPKLRKALSYllggvlvvddldnaLELAKKlrpgy 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   251 -------------------RAERELEKLhNREDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKDDIQTK 307
Cdd:TIGR02168  646 rivtldgdlvrpggvitggSAKTNSSIL-ERRREIEELEEKIEELEEKIAELEKALAELRKeleeLEEELEQLRKELEEL 724

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   308 SEQIQQMADKILELEEKHR--EAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKI 384
Cdd:TIGR02168  725 SRQISALRKDLARLEAEVEqlEERIAQLSKELtELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   385 LSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 464
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAS 884

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   465 ISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRqakteleettAEAE 544
Cdd:TIGR02168  885 LEEALALLRSELEELSEELREL----ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS----------EEYS 950

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   545 EEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDN-------AELNNQNFYLSKQLDEASGAndeIVQLRSEVD 617
Cdd:TIGR02168  951 LTLEEAEALENKIEDDEEEARRR---LKRLENKIKELGPVNlaaieeyEELKERYDFLTAQKEDLTEA---KETLEEAIE 1024


                   ....*....
gi 568936828   618 HLRREITER 626
Cdd:TIGR02168 1025 EIDREARER 1033
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 242-784 5.59e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.00  E-value: 5.59e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   242 LQNIRQAKERAERELEK--------LHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSEQIQQ 313
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   314 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KESLENMMQRHEE 376
Cdd:TIGR04523  101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   377 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 451
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   452 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 516
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   517 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 594
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   595 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREM------QLTSQKQAQLSA--------------------PDLQTM 646
Cdd:TIGR04523  419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELiiknldNTRESLETQLKVlsrsinkikqnleqkqkelkSKEKEL 498

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   647 EALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvlgdEKSQFECRVRELQRMLDTEKQSRARA---------DQRIT 717
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKISSLKEKIEKLES-------EKKEKESKISDLEDELNKDDFELKKEnlekeidekNKEIE 571

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828   718 ESRQV----------VELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQ 784
Cdd:TIGR04523  572 ELKQTqkslkkkqeeKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKlKQEVKQ 649
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
206-675 8.38e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 86.66  E-value: 8.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  206 EYSKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLEN 285
Cdd:PRK03918  229 EVKELEELKEE----IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEE 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  286 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDN--QIKKDLAD 363
Cdd:PRK03918  305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-LEERHELYEEAKAKKEEleRLKKRLTG 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  364 K--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISE 436
Cdd:PRK03918  384 LtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKR 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLS 507
Cdd:PRK03918  464 IEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKS 543

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  508 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEE 576
Cdd:PRK03918  544 LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEK 619

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  577 QLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTML 656
Cdd:PRK03918  620 ELKKLEEE----------LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRR 689

                         490
                  ....*....|....*....
gi 568936828  657 EEQVLDLEALNDELLEKER 675
Cdd:PRK03918  690 EEIKKTLEKLKEELEEREK 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 11-788 2.33e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 2.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKAL 90
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    91 QLLHDIREQSRKLQEIKEqeyqaQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQHKLMKVVSH 170
Cdd:TIGR02168  334 ELAEELAELEEKLEELKE-----ELESLEAELEELEAELEELESRLEELEEQL-------ETLRSKVAQLELQIASLNNE 401

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   171 PPRGDSGGTALDDLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE 250
Cdd:TIGR02168  402 IERLEARLERLEDRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   251 RAERELEKLHNREDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ------------------ 312
Cdd:TIGR02168  472 EAEQALDAAERELAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalggrlq 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   313 -------QMADKILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM------ 371
Cdd:TIGR02168  549 avvvenlNAAKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvv 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   372 --------QRHEEEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMISELR 438
Cdd:TIGR02168  629 ddldnaleLAKKLRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIAELE 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   439 QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQL 515
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEEL 777

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   516 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyl 595
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE------------ 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   596 skqldEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlqtmEALKTTCTMLEEQVLDLEALNDELLEKER 675
Cdd:TIGR02168  846 -----QIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE-----EALALLRSELEELSEELRELESKRSELRR 915

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   676 QWEAwrsvLGDEKSQFECRVRELQRMLDtEKQSRARADQRITEsrQVVELAVKEHKAEILALQQALK--EQKLKA----- 748
Cdd:TIGR02168  916 ELEE----LREKLAQLELRLEGLEVRID-NLQERLSEEYSLTL--EEAEALENKIEDDEEEARRRLKrlENKIKElgpvn 988

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*...
gi 568936828   749 -------ESLSDKLNDLEKKHAMLEMNARSLQQKL-ETERELKQRLLE 788
Cdd:TIGR02168  989 laaieeyEELKERYDFLTAQKEDLTEAKETLEEAIeEIDREARERFKD 1036
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 35-932 3.96e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 84.64  E-value: 3.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    35 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 114
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   115 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEfKRKANECQHKLMKvvshpprgdsggtalddlhkmqghAGLT 194
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD-EQEEIESSKQEIE------------------------KEEE 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   195 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 274
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELK 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   275 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 354
Cdd:pfam02463  346 ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEK 425

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   355 NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMI 434
Cdd:pfam02463  426 KEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKA 505

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   435 SELrqqkfyletqAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLehEEQKLELKRQLTELQLSLQERESQ 514
Cdd:pfam02463  506 RSG----------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV--IVEVSATADEVEERQKLVRALTEL 573

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   515 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 594
Cdd:pfam02463  574 PLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVS 653

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   595 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKE 674
Cdd:pfam02463  654 LEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL--AKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQ 731

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   675 RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvvelAVKEHKAEILALQQALKEQKLKAESLSDK 754
Cdd:pfam02463  732 DKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKE-------LAEEREKTEKLKVEEEKEEKLKAQEEELR 804

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   755 LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLEN 834
Cdd:pfam02463  805 ALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEEL 879

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   835 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 914
Cdd:pfam02463  880 EEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEE 959

                          890
                   ....*....|....*...
gi 568936828   915 KTRIELRSAREEAAHRKA 932
Cdd:pfam02463  960 ERNKRLLLAKEELGKVNL 977
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 206-829 9.88e-16

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 83.48  E-value: 9.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   206 EYSKLEKINAEQQlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEErrhsLEN 285
Cdd:TIGR00618  201 LRSQLLTLCTPCM--PDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE----LRA 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   286 KVKRLETMERRENRlkddiQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVldnqiKKDLADKE 365
Cdd:TIGR00618  275 QEAVLEETQERINR-----ARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-----QSSIEEQR 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   366 SLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 442
Cdd:TIGR00618  345 RLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQG 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   443 YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLRevSLEHEEQKLELKRQLTelqlslqERESQLTALQAAR 522
Cdd:TIGR00618  425 QLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ--SLKEREQQLQTKEQIH-------LQETRKKAVVLAR 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   523 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------NFYLS 596
Cdd:TIGR00618  496 LLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQmqeiqqSFSIL 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   597 KQLDEASGANDEIV-QLRSEVDHLRREITEREMQLTSQKQAQLSA--PDLQTMEALKTTCTMLEEQVLDLEALNDELLE- 672
Cdd:TIGR00618  576 TQCDNRSKEDIPNLqNITVRLQDLTEKLSEAEDMLACEQHALLRKlqPEQDLQDVRLHLQQCSQELALKLTALHALQLTl 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   673 -KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 751
Cdd:TIGR00618  656 tQERVREHALSIRVLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828   752 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 829
Cdd:TIGR00618  731 GSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 277-989 2.63e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 82.09  E-value: 2.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   277 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSEQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 349
Cdd:pfam15921   81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   350 IKVLDNQIKKDLADK-ESLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 402
Cdd:pfam15921  157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   403 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS--- 474
Cdd:pfam15921  237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   475 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 553
Cdd:pfam15921  317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   554 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 615
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   616 VDHLRR---EITEREMQLTS-------------QKQAQLSAPD-------------LQTMEALKTTCTMLEEQVLDLEAL 666
Cdd:pfam15921  474 KEMLRKvveELTAKKMTLESsertvsdltaslqEKERAIEATNaeitklrsrvdlkLQELQHLKNEGDHLRNVQTECEAL 553

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   667 NDELLEKERQWEAWRSVLGD-----------------EKSQFECRVRELQRMLDTEKQSRARADQRITE-SRQVVELAVK 728
Cdd:pfam15921  554 KLQMAEKDKVIEILRQQIENmtqlvgqhgrtagamqvEKAQLEKEINDRRLELQEFKILKDKKDAKIRElEARVSDLELE 633

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   729 EHK-----AEILALQQALKEQKLK----AESLSDKLNDLEKKHAMLEMNARSLQQKLE-TERELKQRLLEEQAKLQQ--- 795
Cdd:pfam15921  634 KVKlvnagSERLRAVKDIKQERDQllneVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtTTNKLKMQLKSAQSELEQtrn 713

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   796 ---QMDLQKNHIFRLTQGLQEALD----RADLLKTERSDLEYQLENI---QVLYSHEKVKMegtiSQQTKLIDFLQAKMD 865
Cdd:pfam15921  714 tlkSMEGSDGHAMKVAMGMQKQITakrgQIDALQSKIQFLEEAMTNAnkeKHFLKEEKNKL----SQELSTVATEKNKMA 789

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   866 QPAKKKKGLFSRRKEDPAlptqvplqynELKLALEKEKARCAELEEALQktRIELRSAREEAAHR---KATDHP-HPSTP 941
Cdd:pfam15921  790 GELEVLRSQERRLKEKVA----------NMEVALDKASLQFAECQDIIQ--RQEQESVRLKLQHTldvKELQGPgYTSNS 857

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 568936828   942 ATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 989
Cdd:pfam15921  858 SMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
PTZ00121 PTZ00121
MAEBL; Provisional
 2-880 5.35e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 81.34  E-value: 5.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARME 81
Cdd:PTZ00121 1096 AFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKA 1172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   82 VSQEDDKALQLLHDIR--EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKAN 158
Cdd:PTZ00121 1173 EDAKKAEAARKAEEVRkaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAE 1240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  159 ECQHklmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTE- 237
Cdd:PTZ00121 1241 EAKK------AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEa 1314

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  238 --ATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQqma 315
Cdd:PTZ00121 1315 kkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--- 1391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  316 dKILELEEKHREAQVSAQhlevHLKQKEqhyEEKIKVldNQIKKDLADKESLENMMQRHEE--EAHEKGKILSEQKamiN 393
Cdd:PTZ00121 1392 -KADEAKKKAEEDKKKAD----ELKKAA---AAKKKA--DEAKKKAEEKKKADEAKKKAEEakKADEAKKKAEEAK---K 1458

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  394 AMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS 471
Cdd:PTZ00121 1459 AEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEakKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  472 DKSRLLELETRLREVSLEHEEQKLELKRQLTElqlslQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALT 551
Cdd:PTZ00121 1537 DEAKKAEEKKKADELKKAEELKKAEEKKKAEE-----AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  552 AHRDEIQR-KFDALRNSctviTDLEEQLNQLTEDNAELNNQNFYLSKQlDEASGANDEIVQLRSEVDHLRREITEREMQL 630
Cdd:PTZ00121 1612 AKKAEEAKiKAEELKKA----EEEKKKVEQLKKKEAEEKKKAEELKKA-EEENKIKAAEEAKKAEEDKKKAEEAKKAEED 1686

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  631 TSQKQAQLSAPdlqtmealkttctmlEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRA 710
Cdd:PTZ00121 1687 EKKAAEALKKE---------------AEEAKKAEELKKKEAEEKKKAEELKK----AEEENKIKAEEAKKEAEEDKKKAE 1747

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  711 RADQRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLnDLEKKHAMLEMNARSLQQ------------KL 776
Cdd:PTZ00121 1748 EAKKDEEEKKKIAHLKKEEEKKaeEIRKEKEAVIEEELDEEDEKRRM-EVDKKIKDIFDNFANIIEggkegnlvindsKE 1826

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  777 ETERELKQRLLEEQAKLQQQMDLQKnHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK---MEGTISQQ 853
Cdd:PTZ00121 1827 MEDSAIKEVADSKNMQLEEADAFEK-HKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDkddIEREIPNN 1905

                         890       900       910
                  ....*....|....*....|....*....|
gi 568936828  854 T---KLIDFLQAKMDQPAKKKKGLFSRRKE 880
Cdd:PTZ00121 1906 NmagKNNDIIDDKLDKDEYIKRDAEETREE 1935
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 215-914 7.84e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.50  E-value: 7.84e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   215 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgiKKKLVEAEERRHSLENKVKRLETME 294
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLK--EKREYEGYELLKEKEALERQKEAIE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   295 RRENRLKDDIQTKSEQIQQMADKILELEEKHRE-------------AQVSAQHLEVH-----LKQKEQHYEEKIKVLDNQ 356
Cdd:TIGR02169  244 RQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkikdlgeeeqLRVKEKIGELEaeiasLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   357 IKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISE 436
Cdd:TIGR02169  324 LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE-------TRDELKDYREKLEK 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERES 513
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQlaaDLSKYEQELYDLKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   514 QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR---------------------NSCTVIT 572
Cdd:TIGR02169  477 EYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAqlgsvgeryataievaagnrlNNVVVED 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   573 DL--EEQLNQLTEDNA------ELNN-QNFYLSKQLDEASGANDEIVQL--------------------RSEVDHLRR-- 621
Cdd:TIGR02169  557 DAvaKEAIELLKRRKAgratflPLNKmRDERRDLSILSEDGVIGFAVDLvefdpkyepafkyvfgdtlvVEDIEAARRlm 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   622 ----------EITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF 691
Cdd:TIGR02169  637 gkyrmvtlegELFEKSGAMTGGSRAPRGGILFSR--SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDA 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   692 ECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMn 768
Cdd:TIGR02169  715 SRKIGEIEKEIEQLEQEEEKLKERLEELEedlSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   769 aRSLQQKLETERELKQRLLEEQAKLQQqmDLQKNHIFR--LTQGLQEALDRADLLKTERSDLEYQLENIQVlyshEKVKM 846
Cdd:TIGR02169  794 -PEIQAELSKLEEEVSRIEARLREIEQ--KLNRLTLEKeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNG----KKEEL 866

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828   847 EGTISQqtklidfLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQ 914
Cdd:TIGR02169  867 EEELEE-------LEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLE 927
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-622 7.85e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.37  E-value: 7.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   84 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQ 161
Cdd:COG1196   313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEeeLEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  162 HKlmkvvshpprgdsggtALDDLHKMQGHAGLTSAKDQgkpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 241
Cdd:COG1196   393 RA----------------AAELAAQLEELEEAEEALLE---------RLERLEEELEELEEALAELEEEEEEEEEALEEA 447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  242 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQ---MADKI 318
Cdd:COG1196   448 AEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVA 527

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:COG1196   528 VLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASD 607

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  399 IRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkSR 475
Cdd:COG1196   608 LREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EE 683

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  476 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 555
Cdd:COG1196   684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936828  556 EIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 622
Cdd:COG1196   764 ELERE----------LERLEREIEALgpvnllaIEEYEELEERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
246-847 1.71e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.34  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  246 RQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH 325
Cdd:PRK03918  144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  326 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 405
Cdd:PRK03918  224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  406 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLRE 485
Cdd:PRK03918  282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  486 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 560
Cdd:PRK03918  350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  561 FDALRNS------CTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM--QLTS 632
Cdd:PRK03918  428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELaeQLKE 507

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  633 QKQaQLSAPDLQTMEALKTTCTMLEEQVLDLEA----LNDELLEKErqweawrsvlgdeksQFECRVRELQRMLDTEKQS 708
Cdd:PRK03918  508 LEE-KLKKYNLEELEKKAEEYEKLKEKLIKLKGeiksLKKELEKLE---------------ELKKKLAELEKKLDELEEE 571

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  709 RARADQRITE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE 781
Cdd:PRK03918  572 LAELLKELEElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828  782 LKQRLLEEQ-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 847
Cdd:PRK03918  652 LEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 29-783 3.30e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.57  E-value: 3.30e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    29 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 108
Cdd:TIGR02169  216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   109 QEY----------QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHpprgdsgg 178
Cdd:TIGR02169  287 EEQlrvkekigelEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE-------- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   179 talddlhkmqghagLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKastEATELLQNIRQAKERAERELEK 258
Cdd:TIGR02169  359 --------------YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKR---EINELKRELDRLQEELQRLSEE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   259 LHNREDSSEGIKKKLVEAEERRhslENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVH 338
Cdd:TIGR02169  422 LADLNAAIAGIEAKINELEEEK---EDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQ 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   339 LKQKEQ---HYEEKIKVLDNQIKK-------------------DLADKESLENMMQRHEEEAHEKGKILSEQKAM----- 391
Cdd:TIGR02169  499 ARASEErvrGGRAVEEVLKASIQGvhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratfl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   392 -INAMDSKIRSLE--------QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeq 461
Cdd:TIGR02169  579 pLNKMRDERRDLSilsedgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL---------- 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   462 LEKI-SHQDHSDKSRLLELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET 539
Cdd:TIGR02169  649 FEKSgAMTGGSRAPRGGILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQL 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   540 TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTED----NAELNNQNFYLSKQL-----DEASGANDEIV 610
Cdd:TIGR02169  729 EQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDlhklEEALNDLEARLSHSRipeiqAELSKLEEEVS 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   611 QLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKE---RQWEAWRSVLG 685
Cdd:TIGR02169  809 RIEARLREIEQKLNRLtlEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLK 888

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   686 DEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEH--------------------KAEILALQ---Q 739
Cdd:TIGR02169  889 KERDELEAQLRELERKIEELEAQIEKKRKRLselKAKLEALEEELSEIedpkgedeeipeeelsledvQAELQRVEeeiR 968

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*...
gi 568936828   740 ALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELK 783
Cdd:TIGR02169  969 ALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-527 6.13e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 77.41  E-value: 6.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    2 EKKLLIKSKElqDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdLATYITECSSLKRSLEQarmE 81
Cdd:PRK03918  180 RLEKFIKRTE--NIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEG---S 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   82 VSQEDDKALQLLHDIREQSRKLQEIKE--------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLA-A 150
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEkvkelkelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINgiEERIKeL 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  151 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE---VGEYSKLEKINAEQQLKIQELQEK 227
Cdd:PRK03918  334 EEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPeklEKELEELEKAKEEIEEEISKITAR 413

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  228 LEKAVKASTEATELLQNIRQAKERAE---RELEKLHNREDSSE------GIKKKLVEAEERRHSLENKVKRLETMERREN 298
Cdd:PRK03918  414 IGELKKEIKELKKAIEELKKAKGKCPvcgRELTEEHRKELLEEytaelkRIEKELKEIEEKERKLRKELRELEKVLKKES 493

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  299 RLKddiqtkseQIQQMADKILELEEKHREaqVSAQHLEVHLKQKEQHYEEKIKVLDNQ--IKKDLADKESLENMMQRHEE 376
Cdd:PRK03918  494 ELI--------KLKELAEQLKELEEKLKK--YNLEELEKKAEEYEKLKEKLIKLKGEIksLKKELEKLEELKKKLAELEK 563

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  377 EAHEKGKILSE-QKAMINAMDSKIRSLEQRIVELSEANK---LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 452
Cdd:PRK03918  564 KLDELEEELAElLKELEELGFESVEELEERLKELEPFYNeylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  453 AQNRKLEEQLEKISHQDHSDKS-RLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 527
Cdd:PRK03918  644 ELRKELEELEKKYSEEEYEELReEYLELSRELAGL----RAELEELEKRREEIKKTLEKLKEELEEREKAKKELEK 715
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 21-630 9.20e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.08  E-value: 9.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    21 KMEQEMTRLHRRVSEVEAVL------SQKEVELKASETQRSLlEQDLATYITECSSLKRSLEQARmevSQEDDKALQLlH 94
Cdd:pfam15921  228 ELDTEISYLKGRIFPVEDQLealkseSQNKIELLLQQHQDRI-EQLISEHEVEITGLTEKASSAR---SQANSIQSQL-E 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    95 DIREQSRKlqeiKEQEYQAQVEEMRLMMNQLEEDLVSARRRSD-----------LYESELRESRLAAEEFKRKANECQHK 163
Cdd:pfam15921  303 IIQEQARN----QNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieelekqlvLANSELTEARTERDQFSQESGNLDDQ 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   164 LMKVvshpprgdsggtaLDDLHKMQGHagLTSAKDQGK----PEVGEYSKLEKINAEQQLKIQELQ--EKLEKAVKASTE 237
Cdd:pfam15921  379 LQKL-------------LADLHKREKE--LSLEKEQNKrlwdRDTGNSITIDHLRRELDDRNMEVQrlEALLKAMKSECQ 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   238 A-TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEaeerrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMAD 316
Cdd:pfam15921  444 GqMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVE------ELTAKKMTLESSERTVSDLTASLQEKERAIEATNA 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   317 KILELEEKhreAQVSAQHLEvHLKQKEQHYEEkIKVLDNQIKKDLADK--------ESLENMMQ---------------- 372
Cdd:pfam15921  518 EITKLRSR---VDLKLQELQ-HLKNEGDHLRN-VQTECEALKLQMAEKdkvieilrQQIENMTQlvgqhgrtagamqvek 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   373 -RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAGK 450
Cdd:pfam15921  593 aQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVKT 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   451 LEAQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQL 529
Cdd:pfam15921  665 SRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVAM 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   530 RQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASGA 605
Cdd:pfam15921  731 GMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNKM 788

                          650       660
                   ....*....|....*....|....*
gi 568936828   606 NDEIVQLRSEVDHLRREITEREMQL 630
Cdd:pfam15921  789 AGELEVLRSQERRLKEKVANMEVAL 813
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
192-702 7.76e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.92  E-value: 7.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  192 GLTSAKDQGKPEVGEYSKlEKINAEQQLkiQELQEKLEKAVKASTEATELLQNI---RQAKERAERELEKLHNR------ 262
Cdd:PRK02224  210 GLESELAELDEEIERYEE-QREQARETR--DEADEVLEEHEERREELETLEAEIedlRETIAETEREREELAEEvrdlre 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  263 --EDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKD-------DIQTKSEQIQQMADKILELEEKHREAQVSAQ 333
Cdd:PRK02224  287 rlEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDrleecrvAAQAHNEEAESLREDADDLEERAEELREEAA 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  334 HLEVHLKQKE---QHYEEKIKVLDNQI---KKDLAD-KESLENMMQRHEEEAHEKgkilSEQKAMINAMDSKIRSLEQRI 406
Cdd:PRK02224  367 ELESELEEAReavEDRREEIEELEEEIeelRERFGDaPVDLGNAEDFLEELREER----DELREREAELEATLRTARERV 442

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  407 VELSEAnkLAANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhsdksRLLELETRLR 484
Cdd:PRK02224  443 EEAEAL--LEAGKCPECGQPVEGSPhvETIEEDRERVEELEAELEDLEEEVEEVEERLERAE--------DLVEAEDRIE 512

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  485 EVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKF 561
Cdd:PRK02224  513 RL----EERREDLEELIAERRETIEEKRERAEELRERAAELEAeaeEKREAAAEAEEEAEEAREEVAELNSKLAELKERI 588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  562 DALRNSCTV---ITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRRE---------------I 623
Cdd:PRK02224  589 ESLERIRTLlaaIADAEDEIERLREKREALAELNDERRERLAEKR---ERKRELEAEFDEARIEearedkeraeeyleqV 665

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  624 TEREMQLTSQKQAQLSA-----PDLQTMEALKTTCTMLEEQVLDLEALNDELlekerqwEAWRSVLGDEKSQFECR-VRE 697
Cdd:PRK02224  666 EEKLDELREERDDLQAEigaveNELEELEELRERREALENRVEALEALYDEA-------EELESMYGDLRAELRQRnVET 738


                  ....*
gi 568936828  698 LQRML 702
Cdd:PRK02224  739 LERML 743
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-645 1.40e-12

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 73.08  E-value: 1.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKELQDSQDKchKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463  343 ELKELEIKREAEEEEEE--ELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDL 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    82 VSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEM-RLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKA 157
Cdd:pfam02463  421 LKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQElKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKleeRSQ 500

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   158 NECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGE-----------------YSKLEKINAEQQLK 220
Cdd:pfam02463  501 KESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVivevsatadeveerqklVRALTELPLGARKL 580

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   221 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK----LHNREDSSEGIKKKLVEAE-----ERRHSLENKVKRLE 291
Cdd:pfam02463  581 RLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDdkraKVVEGILKDTELTKLKESAkakesGLRKGVSLEEGLAE 660

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   292 TMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM 371
Cdd:pfam02463  661 KSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKL 740

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   372 QRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGK 450
Cdd:pfam02463  741 LKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEeAELLEEE 820

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAArAALESQLR 530
Cdd:pfam02463  821 QLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESK-EEKEKEEK 899

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   531 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIV 610
Cdd:pfam02463  900 KELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMA 979

                          650       660       670
                   ....*....|....*....|....*....|....*
gi 568936828   611 QLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQT 645
Cdd:pfam02463  980 IEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEE 1014
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
197-637 1.58e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.49  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  197 KDQGKPEVGEYSKLEKinAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKkklvE 275
Cdd:COG4717    60 KPQGRKPELNLKELKE--LEEELKeAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ----E 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  276 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSEQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 347
Cdd:COG4717   134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  348 EKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 425
Cdd:COG4717   213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  426 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 500
Cdd:COG4717   293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  501 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 566
Cdd:COG4717   369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936828  567 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQAQ 637
Cdd:COG4717   440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLAL 499
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 995-1049 2.59e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 63.19  E-value: 2.59e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  995 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 1049
Cdd:cd20821     1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 208-632 5.20e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.82  E-value: 5.20e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   208 SKLEKINAEQQLKIQELQEKLEKAVkasteatellQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:TIGR04523  228 NQLKDNIEKKQQEINEKTTEISNTQ----------TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   288 KRLETMERRE--NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLA 362
Cdd:TIGR04523  298 SDLNNQKEQDwnKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEekqNEIEKLKK 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   363 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivelsEANKLAANSSLFTQRNMKAQEEmISELRQQKF 442
Cdd:TIGR04523  378 ENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ------EKELLEKEIERLKETIIKNNSE-IKDLTNQDS 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   443 YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE---EQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:TIGR04523  451 VKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLTKKISSLKEKIEKLE 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   520 AARAALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSC--TVITDLEEQLNQLTEDNAELNNQNFYLSK 597
Cdd:TIGR04523  531 SEKKEKESKISDLE---------------------DELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLKKKQEEKQE 589

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 568936828   598 QLDeasgandeivQLRSEVDHLRREITEREMQLTS 632
Cdd:TIGR04523  590 LID----------QKEKEKKDLIKEIEEKEKKISS 614
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
346-931 5.47e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.86  E-value: 5.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  346 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 425
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  426 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 503
Cdd:PRK03918  232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  504 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 583
Cdd:PRK03918  305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  584 DNAELNNQNF-YLSKQLDEASGAN----DEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEE 658
Cdd:PRK03918  377 LKKRLTGLTPeKLEKELEELEKAKeeieEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  659 QVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEILA-- 736
Cdd:PRK03918  457 YTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLEELEkk 523

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  737 --LQQALKEQ--KLKAESLS-----DKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQknhifrl 807
Cdd:PRK03918  524 aeEYEKLKEKliKLKGEIKSlkkelEKLEELKKKLAELEKKLDELEEELA---ELLKELEELGFESVEELEER------- 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  808 TQGLQEALDRADLLKTERSDLEYQLENIQVLYShEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptq 887
Cdd:PRK03918  594 LKELEPFYNEYLELKDAEKELEREEKELKKLEE-ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELRE------ 666

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 568936828  888 vplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 931
Cdd:PRK03918  667 ---EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
PRK01156 PRK01156
chromosome segregation protein; Provisional
 43-644 1.01e-11

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 70.32  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   43 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 120
Cdd:PRK01156  172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  121 MMNQLEEdlvsarrrSDLYESELR--ESRLAAEEFKR-KANECQHKLMKVVSHPprgdsggtALDDLHKMQGHAGLtsak 197
Cdd:PRK01156  244 LSSLEDM--------KNRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDP--------VYKNRNYINDYFKY---- 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  198 dqgKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEA 276
Cdd:PRK01156  304 ---KNDIENKKQiLSNIDAE----INKYHAIIKKL--------SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSY 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  277 EErrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEK 349
Cdd:PRK01156  369 LK---SIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRN 445

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  350 IKVLDNQIK-----KDLADKESlENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLF 422
Cdd:PRK01156  446 MEMLNGQSVcpvcgTTLGEEKS-NHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKI 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  423 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR-LLELETrlrevsleHEEQKLELKRQL 501
Cdd:PRK01156  525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVIsLIDIET--------NRSRSNEIKKQL 596

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  502 TELQLSLQERESQLTALQAAraaLESQLRQAKTELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 581
Cdd:PRK01156  597 NDLESRLQEIEIGFPDDKSY---IDKSIREIENEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEI 672

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828  582 TEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQ 644
Cdd:PRK01156  673 TSRINDIEDNLKKSRKALDDAkanrARLESTIEILRTRINELSDRINDINETLESMKKIKKAIGDLK 739
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 249-932 1.17e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.10  E-value: 1.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   249 KERAERELEKLHNREDSSEGIKKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEE 323
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   324 KHREAQVSAQHLEVHLKQKEQHYEE---KIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ----KAMI 392
Cdd:TIGR02169  252 ELEKLTEEISELEKRLEEIEQLLEElnkKIKDLGeeeqLRVKEKIGELEAEIASLERSIAEKERELEDAEERlaklEAEI 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   393 NAMDSKIRSLEQRIVElsEANKLAANSSLFtqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS- 471
Cdd:TIGR02169  332 DKLLAEIEELEREIEE--ERKRRDKLTEEY-----AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINEl 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   472 --DKSRLLELETRLREVSLEH-------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 542
Cdd:TIGR02169  405 krELDRLQEELQRLSEELADLnaaiagiEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   543 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDhlrre 622
Cdd:TIGR02169  485 LSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAV----- 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   623 iTEREMQLTSQKQAQ----LSAPDLQTMEALKTtcTMLEEQVLDLeALNdeLLEKERQWE-AWRSVLGDE--KSQFECRV 695
Cdd:TIGR02169  560 -AKEAIELLKRRKAGratfLPLNKMRDERRDLS--ILSEDGVIGF-AVD--LVEFDPKYEpAFKYVFGDTlvVEDIEAAR 633

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   696 RELQ--RM--LDTE------------KQSRARADQRITESRQVVELA--VKEHKAEILALQQALKEQKLKAESLSDKLND 757
Cdd:TIGR02169  634 RLMGkyRMvtLEGElfeksgamtggsRAPRGGILFSRSEPAELQRLRerLEGLKRELSSLQSELRRIENRLDELSQELSD 713

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   758 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLT---QGLQEALD--RADLLKTERSDLEYQL 832
Cdd:TIGR02169  714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHklEEALNDLEARLSHSRI 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   833 ENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEA 912
Cdd:TIGR02169  794 PEIQAELS----KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEE 869

                          730       740
                   ....*....|....*....|
gi 568936828   913 LQKTRIELRSAREEAAHRKA 932
Cdd:TIGR02169  870 LEELEAALRDLESRLGDLKK 889
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 597-931 1.73e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 1.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   597 KQLDEASGA----NDEIVQLRSEVDHLRR--EITEREMQLTSQK---QAQLSAPDLQTMEA-LKTTCTMLEEQVLDLEAL 666
Cdd:TIGR02168  179 RKLERTRENldrlEDILNELERQLKSLERqaEKAERYKELKAELrelELALLVLRLEELREeLEELQEELKEAEEELEEL 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   667 NDELLEKERQWEAWRsvlgDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKE 743
Cdd:TIGR02168  259 TAELQELEEKLEELR----LEVSELEEEIEELQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   744 QKLKAESLSDKLNDLEKKHAMLEM---NARSLQQKLETERELKQRLLEEQ----AKLQQQMDLQKNHIFRLTQGLQEALD 816
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLEAeleELEAELEELESRLEELEEQLETLrskvAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   817 RADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNELK 896
Cdd:TIGR02168  415 RRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDAAE 481

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 568936828   897 LALEKEKARCAELEEALQKTRIELRSAREEAAHRK 931
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
PRK01156 PRK01156
chromosome segregation protein; Provisional
 298-801 2.86e-11

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 68.77  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEE 377
Cdd:PRK01156  186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  378 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 457
Cdd:PRK01156  258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  458 LEEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PRK01156  331 LSV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKK 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  521 ARAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYL 595
Cdd:PRK01156  410 ELNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKI 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  596 SKQLDEASGANDEIVQLRSEVDHL------------------RREITEREMQLTSQKQAQLSAP---------DLQTMEA 648
Cdd:PRK01156  486 REIEIEVKDIDEKIVDLKKRKEYLeseeinksineynkiesaRADLEDIKIKINELKDKHDKYEeiknrykslKLEDLDS 565

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  649 LKTTCTMLEEQV--LDLEALNDELLEKERQWEAWRSVLG-------DEKSQFECRVRELQRMLDT--EKQSRARADQRIT 717
Cdd:PRK01156  566 KRTSWLNALAVIslIDIETNRSRSNEIKKQLNDLESRLQeieigfpDDKSYIDKSIREIENEANNlnNKYNEIQENKILI 645

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  718 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL 793
Cdd:PRK01156  646 EKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETL 725


                  ....*...
gi 568936828  794 QQQMDLQK 801
Cdd:PRK01156  726 ESMKKIKK 733
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1-514 3.34e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.61  E-value: 3.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQAR 79
Cdd:pfam15921  347 LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRN 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    80 MEV-----------SQEDDKALQLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 148
Cdd:pfam15921  426 MEVqrleallkamkSECQGQMERQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTA 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   149 AAEEFKRKANECQHKLMKVVSHPprgdsggtaldDLhKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKL 228
Cdd:pfam15921  504 SLQEKERAIEATNAEITKLRSRV-----------DL-KLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQI 571

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   229 EKAVK-----ASTEATELLQNIRQAKERAERELEK-----LHNREDSsegikkKLVEAEERRHSLE-NKVKRLETMERRE 297
Cdd:pfam15921  572 ENMTQlvgqhGRTAGAMQVEKAQLEKEINDRRLELqefkiLKDKKDA------KIRELEARVSDLElEKVKLVNAGSERL 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 377
Cdd:pfam15921  646 RAVKDIKQERDQLLNEVKTSRNELNSLSEDYEV----LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGS 721

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   378 AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRK 457
Cdd:pfam15921  722 DGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERR 801

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936828   458 LEEqlekishqdhsdksRLLELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 514
Cdd:pfam15921  802 LKE--------------KVANMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 77-811 3.36e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 68.46  E-value: 3.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    77 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEmrlmmNQLEEDLVSARRRSDLYESELresrlAAEEFKRK 156
Cdd:TIGR00618  215 DTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-----LKKQQLLKQLRARIEELRAQE-----AVLEETQE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   157 ANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEkLEKAVKAST 236
Cdd:TIGR00618  285 RINRARKAAPLAAHIKA-----VTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT-LHSQEIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   237 EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQiQQMAD 316
Cdd:TIGR00618  359 DAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQ-QELQQ 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   317 KILELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNqikkdladkesLENMMQRHEEEAHEKGKILSEQKaminam 395
Cdd:TIGR00618  438 RYAELCAAAITCTAQCEKLEkIHLQESAQSLKEREQQLQT-----------KEQIHLQETRKKAVVLARLLELQ------ 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   396 dSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR 475
Cdd:TIGR00618  501 -EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   476 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 555
Cdd:TIGR00618  572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHAL 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   556 EIQRKFDALRNSCTVITDLEEQL---NQLTEDNAE-LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLT 631
Cdd:TIGR00618  652 QLTLTQERVREHALSIRVLPKELlasRQLALQKMQsEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLG 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   632 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsvLGDEKSQFECRVRELQRMLDTEKQSRAR 711
Cdd:TIGR00618  732 SDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ--------TGAELSHLAAEIQFFNRLREEDTHLLKT 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   712 ADQRITESRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 791
Cdd:TIGR00618  804 LEAEIGQEIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNG 880

                          730       740
                   ....*....|....*....|
gi 568936828   792 KLQQQMDLQKNHIFRLTQGL 811
Cdd:TIGR00618  881 INQIKIQFDGDALIKFLHEI 900
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 254-848 4.09e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 68.28  E-value: 4.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   254 RELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLetMERReNRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQ 333
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQL--CEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILH 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   334 HLEVHLKQKeqhyEEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 411
Cdd:pfam01576   79 ELESRLEEE----EERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   412 AN-KLaansslftQRNMKAQEEMISELRQQKFYLETQAGKL-------EAQNRKLEEQLEKishqdhSDKSRlLELETRL 483
Cdd:pfam01576  146 QNsKL--------SKERKLLEERISEFTSNLAEEEEKAKSLsklknkhEAMISDLEERLKK------EEKGR-QELEKAK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   484 REV---SLEHEEQKLELKRQLTELQLSLQERESQLTALQaARAALESQLRQAkteleettaeAEEEIQALTAHRDEIQRK 560
Cdd:pfam01576  211 RKLegeSTDLQEQIAELQAQIAELRAQLAKKEEELQAAL-ARLEEETAQKNN----------ALKKIRELEAQISELQED 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   561 FDALRNSCTVIT----DLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITERemqlTSQKQA 636
Cdd:pfam01576  280 LESERAARNKAEkqrrDLGEELEALKTE----------LEDTLDTTAAQQELRSKREQEVTELKKALEEE----TRSHEA 345

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   637 QLSapdlqtmealkttcTMLEEQVLDLEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD 713
Cdd:pfam01576  346 QLQ--------------EMRQKHTQALEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLE 411

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   714 QritesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQA 791
Cdd:pfam01576  412 G------QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQ 483

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936828   792 KLQ-----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 848
Cdd:pfam01576  484 KLNlstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 662-932 4.27e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  662 DLEALNDELLEKERQWEAwrsvLGDEKSQFEcRVRELQRMLDT-EKQSRARADQRITESRQVVELAVKEHKAEILALQQ- 739
Cdd:COG1196   187 NLERLEDILGELERQLEP----LERQAEKAE-RYRELKEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAe 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  740 ------ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 813
Cdd:COG1196   262 laeleaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  814 ALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptqvpLQYN 893
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--------EALL 413

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 568936828  894 ELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 932
Cdd:COG1196   414 ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
72-615 4.72e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.76  E-value: 4.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   72 KRSLEQARMEVSQEDDKAL--------QLLHDIREQSRKLQEIKEQEyQAQVEEMRLMMNQLEEdlvsARRRSDLYESEL 143
Cdd:PRK02224  186 RGSLDQLKAQIEEKEEKDLherlngleSELAELDEEIERYEEQREQA-RETRDEADEVLEEHEE----RREELETLEAEI 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  144 RESRLAAEEFKRKANECQHKLMKvvshppRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvgEYSKLEKINAEQQlkiQE 223
Cdd:PRK02224  261 EDLRETIAETEREREELAEEVRD------LRERLEELEEERDDLLAEAGLDDADAEAVEA--RREELEDRDEELR---DR 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  224 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKlhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRenrlkdd 303
Cdd:PRK02224  330 LEECRVAAQAHNEEAESLREDADDLEERAEELREE---AAELESELEEAREAVEDRREEIEELEEEIEELRER------- 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  304 IQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADKESLENMMQRHEE 376
Cdd:PRK02224  400 FGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHVETIEEDRERVEE 479

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  377 EAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELRQQKFYLETQAGK 450
Cdd:PRK02224  480 LEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELRERAAELEAEAEE 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQERESQLTALQAA 521
Cdd:PRK02224  556 KREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELNDERRERLAEKRER 635

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  522 RAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQLTEDNAELNNQNF 593
Cdd:PRK02224  636 KRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEELRERREALENRVE 708

                         570       580
                  ....*....|....*....|..
gi 568936828  594 YLSKQLDEASGANDEIVQLRSE 615
Cdd:PRK02224  709 ALEALYDEAEELESMYGDLRAE 730
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
210-794 4.80e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.76  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  210 LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER---ELEKLhnREDSSEGIKKKLVEAEERRhslENK 286
Cdd:PRK02224  211 LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETleaEIEDL--RETIAETEREREELAEEVR---DLR 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  287 VKRLETMERRENRLKD------DIQTKSEQIQQMADKILELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKD 360
Cdd:PRK02224  286 ERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEEL 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  361 LADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 440
Cdd:PRK02224  362 REEAAELESELEEAREA-------VEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT 434

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  441 kfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PRK02224  435 ---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIE--------EDRERVEELEAELEDLEEEVEEVEERLERAED 503

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  521 ARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlD 600
Cdd:PRK02224  504 LVEA-EDRIERLEERREDLE-------ELIAERRETIEEK--------------RERAEELRERAAELE----------A 551

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  601 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 680
Cdd:PRK02224  552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKER------IESLERIRTLLAAIADAEDEIERLREKREALAELNDER 625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  681 RSVLGDEKSqfecRVRELQRMLDTEKQSRARADQRITESRQvvelavkehkaeilalqqalkeqklkaESLSDKLNDLEK 760
Cdd:PRK02224  626 RERLAEKRE----RKRELEAEFDEARIEEAREDKERAEEYL---------------------------EQVEEKLDELRE 674

                         570       580       590
                  ....*....|....*....|....*....|....
gi 568936828  761 KHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 794
Cdd:PRK02224  675 ERDDLQAEIGAVENELEELEELRERREALENRVE 708
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 993-1050 7.61e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.61e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  993 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 1050
Cdd:cd20823     1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
458-927 1.25e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.60  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  458 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 534
Cdd:PRK02224  192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  535 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 606
Cdd:PRK02224  269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  607 DEIVQLRSEVDHLRREITEREMQLTSQKQA------QLSAPDLQtMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 680
Cdd:PRK02224  349 EDADDLEERAEELREEAAELESELEEAREAvedrreEIEELEEE-IEELRERFGDAPVDLGNAEDFLEELREERDELRER 427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  681 RSVLGDEKSQFECRVRELQRMLDTEKQSRAraDQRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN---- 756
Cdd:PRK02224  428 EAELEATLRTARERVEEAEALLEAGKCPEC--GQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraed 503

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  757 --DLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD 827
Cdd:PRK02224  504 lvEAEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAE 583

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  828 LEYQLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCA 907
Cdd:PRK02224  584 LKERIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKR 637

                         490       500
                  ....*....|....*....|.
gi 568936828  908 ELEEALQKTRIE-LRSAREEA 927
Cdd:PRK02224  638 ELEAEFDEARIEeAREDKERA 658
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-496 1.42e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.24  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLAtyitecsSLKRSLEqa 78
Cdd:PRK03918  292 AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRLE-------ELEERHE-- 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   79 rmevsqEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAN 158
Cdd:PRK03918  363 ------LYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKG 436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  159 ECQhklmkvvshpprgdSGGTALDDLHKMQGHAGLTSakdqgkpEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEA 238
Cdd:PRK03918  437 KCP--------------VCGRELTEEHRKELLEEYTA-------ELKRIEKELKEIEEKERKLRKELRELEKVLKKESEL 495

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  239 TELLQNIRQAKERAER----ELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM 314
Cdd:PRK03918  496 IKLKELAEQLKELEEKlkkyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAEL 575

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  315 ADKILELEEKhreaqvSAQHLEVHLKQKEQHYEEKIKVLDnqIKKDLadkESLENMMQRHEEEAHEKGKILSEQKAMINA 394
Cdd:PRK03918  576 LKELEELGFE------SVEELEERLKELEPFYNEYLELKD--AEKEL---EREEKELKKLEEELDKAFEELAETEKRLEE 644

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  395 MDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSdKS 474
Cdd:PRK03918  645 LRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKA-LE 721

                         490       500
                  ....*....|....*....|..
gi 568936828  475 RLLELETRLREVSLEHEEQKLE 496
Cdd:PRK03918  722 RVEELREKVKKYKALLKERALS 743
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 211-789 1.49e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 66.28  E-value: 1.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   211 EKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--RQAKERAERELEKLHNRE---DSSEGIKKKLVEAEERRHSLEN 285
Cdd:pfam05483  130 EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaRSAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAEN 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   286 -------KVKR-LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQI 357
Cdd:pfam05483  209 arlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENL 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   358 KKDLADKESLENMMqrhEEEAHEKGKILSEQKAMINAMDSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQ 430
Cdd:pfam05483  285 KELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDLQIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   431 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL------ELKRQLTEL 504
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQEL 441

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   505 QLSLQERES-------QLTALQAARAALESQLRQAKTELEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQ 577
Cdd:pfam05483  442 IFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLE 514

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   578 LNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL-----TSQKQAQLSAPDL----QTMEA 648
Cdd:pfam05483  515 LKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkckldKSEENARSIEYEVlkkeKQMKI 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   649 LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQ---------SRARADQRITE- 718
Cdd:pfam05483  592 LENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQkfeeiidnyQKEIEDKKISEe 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   719 --------SRQVVELAVK---------EHK-AEILALQQALKEQ---------------KLKAESLSDKLNDLEKKHAML 765
Cdd:pfam05483  672 klleevekAKAIADEAVKlqkeidkrcQHKiAEMVALMEKHKHQydkiieerdselglyKNKEQEQSSAKAALEIELSNI 751

                          650       660
                   ....*....|....*....|....
gi 568936828   766 EMNARSLQQKLETERELKQRLLEE 789
Cdd:pfam05483  752 KAELLSLKKQLEIEKEEKEKLKME 775
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 997-1045 1.87e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.87e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568936828    997 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1045
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 997-1045 2.17e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.53  E-value: 2.17e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568936828  997 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd00029     1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
367-603 2.38e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 65.42  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  367 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 446
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  447 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 524
Cdd:COG3206   234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  525 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 603
Cdd:COG3206   303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
93-585 2.69e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 2.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   93 LHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKANECQHKLmkvvsh 170
Cdd:COG4717    70 LKELKELEEELKEAEEKE--EEYAELQEELEELEEELEELEAELEELREELEklEKLLQLLPLYQELEALEAEL------ 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  171 pprgdsggtalddlhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEllQNIRQAKE 250
Cdd:COG4717   142 --------------------AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATE--EELQDLAE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  251 RAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMER-RENRLKDDIQTKSEQIQQMADKILELEEKHRE-- 327
Cdd:COG4717   200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGvl 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  328 ---AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 404
Cdd:COG4717   280 flvLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  405 RIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKSRLLELETRL 483
Cdd:COG4717   359 LEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEEL 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  484 REVSLEHEEQKLELKRQLTELQLSLQERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKf 561
Cdd:COG4717   438 EEELEELEEELEELREELAELEAELEQLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP- 516

                         490       500
                  ....*....|....*....|....
gi 568936828  562 dalrnsctVITDLEEQLNQLTEDN 585
Cdd:COG4717   517 --------VLERASEYFSRLTDGR 532
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 3-466 4.20e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 4.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     3 KKLLIKSKELQDSQDKCHK---MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQAR 79
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKnksLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    80 MEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAqveemrlMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANe 159
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEISDLNNQKEQD-------WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQIS- 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   160 cqhKLMKVVSHpprgdsggtalddlhkmqghagLTSAKDQGKPEVGE-YSKLEKINAEQQLKIQELQeKLEkavkasTEA 238
Cdd:TIGR04523  346 ---QLKKELTN----------------------SESENSEKQRELEEkQNEIEKLKKENQSYKQEIK-NLE------SQI 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   239 TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQmadKI 318
Cdd:TIGR04523  394 NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLET---QL 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   319 LELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAM 395
Cdd:TIGR04523  471 KVLSRSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   396 DS---------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 466
Cdd:TIGR04523  551 DFelkkenlekEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLS 630
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
425-829 4.27e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.40  E-value: 4.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  425 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 502
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  503 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 582
Cdd:COG4717   150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  583 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQAQ 637
Cdd:COG4717   227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  638 LSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 711
Cdd:COG4717   307 LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  712 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 791
Cdd:COG4717   387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 568936828  792 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 829
Cdd:COG4717   457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
PTZ00121 PTZ00121
MAEBL; Provisional
 181-917 4.66e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  181 LDDLHKMQGHAGLTSAKDQ------GKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE- 253
Cdd:PTZ00121 1047 IIDEDIDGNHEGKAEAKAHvgqdegLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEd 1126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  254 -RELEKLHNREDSSEGIKKKLVEaEERRHSLENKV---KRLETMERRENRLKDDIQTKSEQIQQMADkiLELEEKHREAQ 329
Cdd:PTZ00121 1127 aRKAEEARKAEDARKAEEARKAE-DAKRVEIARKAedaRKAEEARKAEDAKKAEAARKAEEVRKAEE--LRKAEDARKAE 1203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  330 VSAQHLEVHLKQKEQHYEEKIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKI--LSEQKAMINAMDSKIRSLE 403
Cdd:PTZ00121 1204 AARKAEEERKAEEARKAEDAKKAEAvkkaEEAKKDAEEAKKAEEERNNEEIRKFEEARMahFARRQAAIKAEEARKADEL 1283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  404 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QLEKISHQDHSDKSRLLE 478
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEakkaaEAAKAEAEAAADEAEAAE 1363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  479 LETRLREVSLEHE-------EQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTAEAEEEIQALT 551
Cdd:PTZ00121 1364 EKAEAAEKKKEEAkkkadaaKKKAEEKKKADEAKKKAEEDKKKADELKKAAAA-KKKADEAKKKAEEKKKADEAKKKAEE 1442

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  552 AHR-DEIQRKFDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEI---VQLRSEVDHLRREITER 626
Cdd:PTZ00121 1443 AKKaDEAKKKAEEAKKAEEAKKKAEEAKKaDEAKKKAEEAKKADEAKKKAEEAKKKADEAkkaAEAKKKADEAKKAEEAK 1522

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  627 EMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVL----DLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRELQRML 702
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADELKKAEELkkaeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  703 DTEKQSRARADQRITESRQVVELAVK--EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 780
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKaeEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK 1681

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  781 --ELKQRLLEEQAKLQQQmdlQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgtisqqtklid 858
Cdd:PTZ00121 1682 kaEEDEKKAAEALKKEAE---EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE----------- 1747

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  859 flQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTR 917
Cdd:PTZ00121 1748 --EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIF 1804
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
239-810 4.98e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.40  E-value: 4.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  239 TELLQNIRQA-KERAERELEKLHNREDssegikKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADK 317
Cdd:COG4717    37 STLLAFIRAMlLERLEKEADELFKPQG------RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  318 ILELEEKHREAQVSAQHLEVHLKQKEqhyeekikvldnqikkdlaDKESLENMMQRHEEeahekgkiLSEQKAMINAMDS 397
Cdd:COG4717   111 LEELREELEKLEKLLQLLPLYQELEA-------------------LEAELAELPERLEE--------LEERLEELRELEE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  398 KIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKS 474
Cdd:COG4717   164 ELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  475 RLLELETRLREVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 554
Cdd:COG4717   244 RLKEARLLLLIAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  555 DEIQRKFDALRNSCTVITDLEEqlnqltednaelnnqnfylsKQLDEASGANDEIVQLRSEVDHLRREIteREMQLTSQK 634
Cdd:COG4717   315 ELEEEELEELLAALGLPPDLSP--------------------EELLELLDRIEELQELLREAEELEEEL--QLEELEQEI 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  635 QAQLSAPDLQTMEALKTTCTMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRAR 711
Cdd:COG4717   373 AALLAEAGVEDEEELRAALEQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEE 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  712 ADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 791
Cdd:COG4717   444 LEEELEELRE--ELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA 521

                         570       580
                  ....*....|....*....|
gi 568936828  792 klqqqmdlqkNHIF-RLTQG 810
Cdd:COG4717   522 ----------SEYFsRLTDG 531
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 35-798 7.57e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 64.04  E-value: 7.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    35 EVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR-------KLQ 104
Cdd:pfam01576  300 ELEALKTELEDTLDTTAAQqelRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKrnkanleKAK 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   105 EIKEQEYQAQVEEMRLMMNQLEEdlvSARRRSDLyESELRESRLAAEEFKRKANECQHKLMKVVSHPprgDSGGTALDDL 184
Cdd:pfam01576  380 QALESENAELQAELRTLQQAKQD---SEHKRKKL-EGQLQELQARLSESERQRAELAEKLSKLQSEL---ESVSSLLNEA 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   185 ----HKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQE-----LQEKLEKAVKASTEATELLQNIRQAKERAERE 255
Cdd:pfam01576  453 egknIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEdernsLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK 532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   256 LEKLHNREDSSEGIKKKLV-EAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHReaqvsaqh 334
Cdd:pfam01576  533 LEEDAGTLEALEEGKKRLQrELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQK-------- 604

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   335 levhlKQKEQHYEEKIKVLDNQIKKDLADKESLENmmqrhEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 414
Cdd:pfam01576  605 -----KFDQMLAEEKAISARYAEERDRAEAEAREK-----ETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKD 674

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   415 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDksrlleLETRlrevSLEHEEQK 494
Cdd:pfam01576  675 DVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERD------LQAR----DEQGEEKR 744

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   495 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSCTVI 571
Cdd:pfam01576  745 RQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEEARASRDEI 824

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   572 -----------TDLEEQLNQLTEDNA------------------ELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRRE 622
Cdd:pfam01576  825 laqskesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGKSALQDEKRRLEARIAQLEEE---LEEE 901

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   623 ITEREMQLTSQKQAQLSAPDLQT-MEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQR 700
Cdd:pfam01576  902 QSNTELLNDRLRKSTLQVEQLTTeLAAERSTSQKSESARQQLERQNKELKAKLQEMEgTVKSKFKSSIAALEAKIAQLEE 981

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   701 MLDTEKQSRARADQRITEsrqvvelavKEHKAEILALQqaLKEQKLKAESLSDKLndlEKKHAMLemnaRSLQQKLETER 780
Cdd:pfam01576  982 QLEQESRERQAANKLVRR---------TEKKLKEVLLQ--VEDERRHADQYKDQA---EKGNSRM----KQLKRQLEEAE 1043

                          810
                   ....*....|....*...
gi 568936828   781 ELKQRLLEEQAKLQQQMD 798
Cdd:pfam01576 1044 EEASRANAARRKLQRELD 1061
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 211-870 8.52e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 64.20  E-value: 8.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  211 EKInAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE--------------LEKLHNREDSSEGIKKKLVEA 276
Cdd:COG3096   347 EKI-ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEvdslksqladyqqaLDVQQTRAIQYQQAVQALEKA 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  277 EERRH----SLENKVKRLETMERREN-------------RLKDDIQTKSEQIQQMADKIL-------------ELEEKHR 326
Cdd:COG3096   426 RALCGlpdlTPENAEDYLAAFRAKEQqateevleleqklSVADAARRQFEKAYELVCKIAgeversqawqtarELLRRYR 505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  327 EAQVSAQ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 397
Cdd:COG3096   506 SQQALAQrlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQ 585

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  398 KIRSLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISH 467
Cdd:COG3096   586 QLEQLRARIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQ 665

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  468 QDHSDKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ 511
Cdd:COG3096   666 PGGAEDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfd 745

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  512 ESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtedn 585
Cdd:COG3096   746 DSVFDAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF---- 821

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  586 aelnnqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQAQLSA-PDLQTMEALKTTCTMLEEQVL- 661
Cdd:COG3096   822 ---------VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLkEQLQLLNKLLPQANLLADETLa 892

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  662 ----DLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVE 724
Cdd:COG3096   893 drleELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRP 968

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  725 LAVKEHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ 800
Cdd:COG3096   969 HFSYEDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQ 1048

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  801 KNHifrltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 870
Cdd:COG3096  1049 ADA---------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
376-834 1.24e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  376 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 452
Cdd:COG4913   238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  453 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 528
Cdd:COG4913   316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  529 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 587
Cdd:COG4913   396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  588 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREITEREMQLTSQKQAQLSAPD---LQTMEALKTTC 653
Cdd:COG4913   476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLVYERVRTGLPDPERPRLDPdslAGKLDFKPHPF 547

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  654 TM-LEEQ---------VLDLEAL---------------NDELLEKERQWEAWRS-VLG----DEKSQFECRVRELQRMLD 703
Cdd:COG4913   548 RAwLEAElgrrfdyvcVDSPEELrrhpraitragqvkgNGTRHEKDDRRRIRSRyVLGfdnrAKLAALEAELAELEEELA 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  704 T--EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEqklkAESLSDKLNDLEKKHAMLemnaRSLQQKLETERE 781
Cdd:COG4913   628 EaeERLEALEAELDALQERREALQRLAEYSWDEIDVASAERE----IAELEAELERLDASSDDL----AALEEQLEELEA 699

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568936828  782 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRAD-LLKTERSDLEYQLEN 834
Cdd:COG4913   700 ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaAEDLARLELRALLEE 753
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1250-1501 2.30e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1250 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1321
Cdd:COG5422   868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1322 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1390
Cdd:COG5422   944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1391 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1469
Cdd:COG5422  1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                         250       260       270
                  ....*....|....*....|....*....|...
gi 568936828 1470 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1501
Cdd:COG5422  1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
mukB PRK04863
chromosome partition protein MukB;
217-836 5.22e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 61.51  E-value: 5.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  217 QQLKIQ-------ELQEKLEKAVKASTEATELLQNIRQAKERAERE-------------------------------LEK 258
Cdd:PRK04863  346 QQEKIEryqadleELEERLEEQNEVVEEADEQQEENEARAEAAEEEvdelksqladyqqaldvqqtraiqyqqavqaLER 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  259 -----------LHNREDSSEGIKKKLVEAEERRHSLENKVkrletmerrenRLKDDIQTKSEQIQQMADKIL-------- 319
Cdd:PRK04863  426 akqlcglpdltADNAEDWLEEFQAKEQEATEELLSLEQKL-----------SVAQAAHSQFEQAYQLVRKIAgevsrsea 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  320 -----ELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKV--LDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 389
Cdd:PRK04863  495 wdvarELLRRLREQRhlaEQLQQLRMRLSELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESV 574

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  390 AMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQN 455
Cdd:PRK04863  575 SEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARK 654

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  456 RKLEEQLEKISHQDHSDKSRLLELETRLREVSLE--HEEQKLE-----------------------LKRQLTELQ----- 505
Cdd:PRK04863  655 QALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcped 734

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  506 LSLQE------RESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 573
Cdd:PRK04863  735 LYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQR 814

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  574 LEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTC 653
Cdd:PRK04863  815 LHQAFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGL 874

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  654 TMLEE-----QVLDLEALNDELLEKERQWEAWR--------------------SVLGDEKSQFEcrvrELQRMLDTEKQS 708
Cdd:PRK04863  875 SALNRllprlNLLADETLADRVEEIREQLDEAEeakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQT 950

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  709 RARADQRI---TESRQVVELAVKEHKAEILA----LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQ 773
Cdd:PRK04863  951 QRDAKQQAfalTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYD 1030

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828  774 QKLETERELKQRL----------LEEQAKLQQQmdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 836
Cdd:PRK04863 1031 AKRQMLQELKQELqdlgvpadsgAEERARARRD---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
458-927 5.31e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 5.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  458 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 536
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  537 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------------NFYLSKQLDEASG 604
Cdd:COG4717   126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEEleelleqlslatEEELQDLAEELEE 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  605 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEALNDELLEKERQWEAWRSVL 684
Cdd:COG4717   204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLV 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  685 GdeksqfecrvrelqRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKham 764
Cdd:COG4717   283 L--------------GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR--- 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  765 lemnARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI---- 835
Cdd:COG4717   346 ----IEELQELLREAEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgel 418

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  836 -QVLYSHEKVKMEGTISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE--- 911
Cdd:COG4717   419 eELLEALDEEELEEELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewa 493

                         490
                  ....*....|....*.
gi 568936828  912 ALQKTRIELRSAREEA 927
Cdd:COG4717   494 ALKLALELLEEAREEY 509
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
91-721 5.64e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 61.08  E-value: 5.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   91 QLLHDIREQSRKLQEIKE--QEYQAQVEEMRLMmNQLEEDLVS--ARRRSDLYESELRESRLAAEEFKRKANECQHKLmk 166
Cdd:COG4913   242 EALEDAREQIELLEPIRElaERYAAARERLAEL-EYLRAALRLwfAQRRLELLEAELEELRAELARLEAELERLEARL-- 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  167 vvshpprgDSGGTALDDLHK-MQGHAGltSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQN 244
Cdd:COG4913   319 --------DALREELDELEAqIRGNGG--DRLEQLEREIER---LERELEERERRRARLEALLAALgLPLPASAEEFAAL 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  245 IRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtmeRRENRLKDDIQTKSEQIQQmadkilELEEK 324
Cdd:COG4913   386 RAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLE---RRKSNIPARLLALRDALAE------ALGLD 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  325 HREAQVSAQHLEVhlKQKEQHYEEKI-KVLDNQiKKDLADKESLENMMQRHEEEAHEKGKILSEqKAMINAMDSKIRSLE 403
Cdd:COG4913   457 EAELPFVGELIEV--RPEEERWRGAIeRVLGGF-ALTLLVPPEHYAAALRWVNRLHLRGRLVYE-RVRTGLPDPERPRLD 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  404 QRivelSEANKLAANSSLFTQRnmkAQEEM-----------ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSd 472
Cdd:COG4913   533 PD----SLAGKLDFKPHPFRAW---LEAELgrrfdyvcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR- 596

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  473 ksrlleletRLREVSL---EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQA 549
Cdd:COG4913   597 ---------RIRSRYVlgfDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREA---------------LQR 652

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  550 LTAHRDEiQRKFDALRNSctvITDLEEQLNQLTEDNAELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQ 629
Cdd:COG4913   653 LAEYSWD-EIDVASAERE---IAELEAELERLDASSDDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKE 721

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  630 LTS-QKQAQLSAPDLQTMEALKTtctmlEEQVLDLEALNDELLEKERQWEAwrsvlgdeksqfecrVRELQRMLDTEKQS 708
Cdd:COG4913   722 LEQaEEELDELQDRLEAAEDLAR-----LELRALLEERFAAALGDAVEREL---------------RENLEERIDALRAR 781

                         650
                  ....*....|...
gi 568936828  709 RARADQRITESRQ 721
Cdd:COG4913   782 LNRAEEELERAMR 794
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-799 8.21e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 60.57  E-value: 8.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    82 VSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRL-------MMNQLEED-LVSARRRSDLY-ESELRESRLAa 150
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQldEEEAARQKLQLekvtteaKIKKLEEDiLLLEDQNSKLSkERKLLEERIS- 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   151 eEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvGEYSKLEKINAEQQLKIQELQEKL-- 228
Cdd:pfam01576  163 -EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLE-GESTDLQEQIAELQAQIAELRAQLak 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   229 -EKAVKASTEATELLQNIRQAKERAERELE-KLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenRLKDDIQT 306
Cdd:pfam01576  241 kEEELQAALARLEEETAQKNNALKKIRELEaQISELQEDLESERAARNKAEKQRRDLGEELEALKT------ELEDTLDT 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   307 KSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILS 386
Cdd:pfam01576  315 TAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELR 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   387 EQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEE------MISELRQQKFYLETQAGKLEAQNRKLE 459
Cdd:pfam01576  395 TLQQAKQDSEHKRKKLEGQLQELqARLSESERQRAELAEKLSKLQSElesvssLLNEAEGKNIKLSKDVSSLESQLQDTQ 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   460 EQLEKISHQDHSDKSRLLELE---TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 536
Cdd:pfam01576  475 ELLQEETRQKLNLSTRLRQLEderNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQREL 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   537 EETTAEAEEEIQA---------------------------LTAHRDEIQRKFD-ALRNSCTVITDLEEQLNQLTEDNAEL 588
Cdd:pfam01576  555 EALTQQLEEKAAAydklektknrlqqelddllvdldhqrqLVSNLEKKQKKFDqMLAEEKAISARYAEERDRAEAEAREK 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   589 NNQNFYLSKQLDEASGANDEI----VQLRSEVDHLrreiteremqLTSQKQAQLSAPDL--------QTMEALKTTCTML 656
Cdd:pfam01576  635 ETRALSLARALEEALEAKEELertnKQLRAEMEDL----------VSSKDDVGKNVHELerskraleQQVEEMKTQLEEL 704

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   657 EEQvldLEALNDELLEKERQWEAW----------RSVLGDEK-SQFECRVRELQRMLDTEKQSRARAdqriTESRQVVEL 725
Cdd:pfam01576  705 EDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKrRQLVKQVRELEAELEDERKQRAQA----VAAKKKLEL 777

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828   726 AVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQRlleEQAKLQQQMDL 799
Cdd:pfam01576  778 DLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKNL---EAELLQLQEDL 849
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 207-923 1.66e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 59.97  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  207 YSKLEKINAEQQL---------KIQELQEKLEKAVKASTEATELLQNIRQAKERAER------EL-EKLHNREDSSEGIK 270
Cdd:COG3096   295 FGARRQLAEEQYRlvemareleELSARESDLEQDYQAASDHLNLVQTALRQQEKIERyqedleELtERLEEQEEVVEEAA 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  271 KKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM------ADKILELEEKHREAqvSAQHLEVHLKQKEQ 344
Cdd:COG3096   375 EQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAvqalekARALCGLPDLTPEN--AEDYLAAFRAKEQQ 452

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  345 HYEEkikVLDNQIKKDLAD--KESLENMMQRHE--------EEAHEKGKIL----SEQKAMI---NAMDSKIRSLEQRIV 407
Cdd:COG3096   453 ATEE---VLELEQKLSVADaaRRQFEKAYELVCkiageverSQAWQTARELlrryRSQQALAqrlQQLRAQLAELEQRLR 529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  408 ELSEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR---LLELET 481
Cdd:COG3096   530 QQQNAERLLEEFCQRIGQQLDAAeelEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARapaWLAAQD 609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  482 RLREVSlEHEEQKLELKRQLTELQLSLQERESQLTA----LQAARAALESQLRQAKTELEETTAEAEEEIQALTAH---- 553
Cdd:COG3096   610 ALERLR-EQSGEALADSQEVTAAMQQLLEREREATVerdeLAARKQALESQIERLSQPGGAEDPRLLALAERLGGVllse 688

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  554 -RDEIQRK----FDAL----RNScTVITDLE---EQLNQLT---------EDNAELNNQNFYLSKQLDEASGANDEIVQL 612
Cdd:COG3096   689 iYDDVTLEdapyFSALygpaRHA-IVVPDLSavkEQLAGLEdcpedlyliEGDPDSFDDSVFDAEELEDAVVVKLSDRQW 767

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  613 R----SEVDHLRR-------EITEREMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEALNDEllekerqwEAWR 681
Cdd:COG3096   768 RysrfPEVPLFGRaarekrlEELRAERDELAEQYAKASF-DVQKLQRLHQAFSQFVGGHLAVAFAPDP--------EAEL 838

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  682 SVLGDEKSQFEcrvRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDL 758
Cdd:COG3096   839 AALRQRRSELE---RELAQHRAQEQQLRQQLDQlkeQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAFIQQH 915

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  759 EKKHAMLEMNARSLQQKLETERELKQRLLEeqakLQQQMDLQKNHIFRLTQGLQ--EAL---DRADLLkTERSD----LE 829
Cdd:COG3096   916 GKALAQLEPLVAVLQSDPEQFEQLQADYLQ----AKEQQRRLKQQIFALSEVVQrrPHFsyeDAVGLL-GENSDlnekLR 990

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  830 YQLENIQVLYSHEKVKMEGtisQQTKLIDFLQAKMDQPAK---KKKGLFSRRKEDPALPTQVP--------LQYNELKLA 898
Cdd:COG3096   991 ARLEQAEEARREAREQLRQ---AQAQYSQYNQVLASLKSSrdaKQQTLQELEQELEELGVQADaeaeerarIRRDELHEE 1067

                         810       820
                  ....*....|....*....|....*
gi 568936828  899 LEKEKARCAELEEALQKTRIELRSA 923
Cdd:COG3096  1068 LSQNRSRRSQLEKQLTRCEAEMDSL 1092
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 242-837 1.78e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.47  E-value: 1.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   242 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSlenkvkRLETMERRENRLKDDIQTKSEQIQQMADKiLEL 321
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIAS------RQEERQETSAELNQLLRTLDDQWKEKRDE-LNG 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   322 EEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 399
Cdd:pfam12128  309 ELSAADAAVAKdrSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQN 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   400 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEmiSELRQQkfyletqagkLEAQNRKLEEQLEKIshqdhsdKSRLLEL 479
Cdd:pfam12128  389 NRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQ----------LEAGKLEFNEEEYRL-------KSRLGEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   480 ETRLREVSLEHEEqklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQR 559
Cdd:pfam12128  450 KLRLNQATATPEL-----LLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   560 kfdalrnsctvitdLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIvqLRSEV----DHLRREITEREMQLTSQKQ 635
Cdd:pfam12128  515 --------------LEERQSALDE-----------LELQLFPQAGTLLHF--LRKEApdweQSIGKVISPELLHRTDLDP 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   636 AQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARA 712
Cdd:pfam12128  568 EVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFA 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   713 DQRITESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELK 783
Cdd:pfam12128  645 RTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVE 724

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828   784 QRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 837
Cdd:pfam12128  725 GALDAQLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 356-834 2.47e-08

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 58.98  E-value: 2.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   356 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 433
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   434 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 510
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   511 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 585
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   586 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREmqltsqKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEA 665
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV------KLAQDTGLNLRSPEDLSRRIEQLQQREIVLKE 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   666 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALK 742
Cdd:pfam05557  298 ENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSP 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   743 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDR 817
Cdd:pfam05557  377 QLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELE 456

                          490
                   ....*....|....*..
gi 568936828   818 ADLLKTERSDLEYQLEN 834
Cdd:pfam05557  457 RQRLREQKNELEMELER 473
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 217-465 2.83e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 2.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  217 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLetmERR 296
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL---ERRIAALARRIRALEQELAALEAELAEL---EKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  297 ENRLKDDIQTKSEQIQQMAdkileleekhREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKESLENMMQRHEE 376
Cdd:COG4942    92 IAELRAELEAQKEELAELL----------RALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  377 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 456
Cdd:COG4942   147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223


                  ....*....
gi 568936828  457 KLEEQLEKI 465
Cdd:COG4942   224 ELEALIARL 232
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 995-1046 2.86e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.17  E-value: 2.86e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  995 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 1046
Cdd:cd20812     1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 458-914 3.10e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 58.98  E-value: 3.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   458 LEEQLEKISHQdhsdksrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 530
Cdd:pfam15921   76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   531 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 580
Cdd:pfam15921  149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   581 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPdlQTMEALKTTCTMLEE 658
Cdd:pfam15921  229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSAR--SQANSIQSQLEIIQE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   659 QVLDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKE 729
Cdd:pfam15921  307 QARNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADL 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   730 HKAEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLT 808
Cdd:pfam15921  387 HKRE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   809 QGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQV 888
Cdd:pfam15921  454 QGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRV 526

                          490       500
                   ....*....|....*....|....*...
gi 568936828   889 PLQYNELK-LALEKEKARCAELE-EALQ 914
Cdd:pfam15921  527 DLKLQELQhLKNEGDHLRNVQTEcEALK 554
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 8-343 3.54e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.60  E-value: 3.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     8 KSKELQDSQDKCHKMEQEMTRlhrrvseveavlSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDD 87
Cdd:pfam17380  282 KAVSERQQQEKFEKMEQERLR------------QEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERE 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    88 kalqlLHDIREQSRK--LQEIKEQEYQAQVEEMR-LMMNQLEEDLVSARRRSDLYESelRESRLAAEEFKRKANECQHKL 164
Cdd:pfam17380  350 -----LERIRQEERKreLERIRQEEIAMEISRMReLERLQMERQQKNERVRQELEAA--RKVKILEEERQRKIQQQKVEM 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   165 MKVvshppRGDSGGTALDDLHKMQGHAG--LTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELL 242
Cdd:pfam17380  423 EQI-----RAEQEEARQREVRRLEEERAreMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKIL 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   243 QniRQAKERAERELEKLHNR---EDSSEGIKKKLVEAEERRHSLENKVKRLETMERREnrlkddIQtksEQIQQMADKIL 319
Cdd:pfam17380  498 E--KELEERKQAMIEEERKRkllEKEMEERQKAIYEEERRREAEEERRKQQEMEERRR------IQ---EQMRKATEERS 566

                          330       340
                   ....*....|....*....|....
gi 568936828   320 ELEEKHREAQVSAQHLEVHLKQKE 343
Cdd:pfam17380  567 RLEAMEREREMMRQIVESEKARAE 590
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1-529 3.92e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.19  E-value: 3.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     1 MEKKLLIKSKELQDSQDKCHKMEQEM----TRLHRRVSEVEAV--------------LSQKEV---ELKASETQRSLLEQ 59
Cdd:pfam05483  273 LEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALeedlqiatkticqlTEEKEAqmeELNKAKAAHSFVVT 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    60 DLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqLEE-DLVSARRRSDL 138
Cdd:pfam05483  353 EFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------LEElKKILAEDEKLL 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   139 YESELRESrlAAEEFKRKANECQHKLMkvvshpprgdsggTALDDLHKMQGHAGLTSAKDQgkpevgEYSKlekinaeqq 218
Cdd:pfam05483  422 DEKKQFEK--IAEELKGKEQELIFLLQ-------------AREKEIHDLEIQLTAIKTSEE------HYLK--------- 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   219 lKIQELQEKLEKAVKASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKKlveaeerrhslENKVKRLETM 293
Cdd:pfam05483  472 -EVEDLKTELEKEKLKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENL 539

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   294 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEslENMMQR 373
Cdd:pfam05483  540 EEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEEL 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   374 HEEEAHEKGKILSEQKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLE 452
Cdd:pfam05483  614 HQENKALKKKGSAENKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAI 683

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828   453 AQNR-KLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ-ERESQLTALQAARAALESQL 529
Cdd:pfam05483  684 ADEAvKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKaALEIELSNIKAELLSLKKQL 762
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
237-777 4.33e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.39  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  237 EATELLQNIRQAKE------RAERELEKLHNREDSSEGIkkklVEAEERRHSLENKVKRLETMERREnrlkdDIQTKSEQ 310
Cdd:COG4913   219 EEPDTFEAADALVEhfddleRAHEALEDAREQIELLEPI----RELAERYAAARERLAELEYLRAAL-----RLWFAQRR 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  311 IQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKK-DLADKESLENMMQRHEEEAHEKGKILSEQK 389
Cdd:COG4913   290 LELLEAELEELRAELARLEAELERLEARLDALREELDE----LEAQIRGnGGDRLEQLEREIERLERELEERERRRARLE 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  390 AMINAMDSKIRSLEQRIVELSEANKLAANSSlftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQD 469
Cdd:COG4913   366 ALLAALGLPLPASAEEFAALRAEAAALLEAL----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLERRK 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  470 HSDKSRLLELETRLREvSLEHEEQKL----ELkrqlteLQLSLQERESQLTA-----------------LQAARAALES- 527
Cdd:COG4913   436 SNIPARLLALRDALAE-ALGLDEAELpfvgEL------IEVRPEEERWRGAIervlggfaltllvppehYAAALRWVNRl 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  528 QLRQAKTELEETTAEAEEEIQALTAH-----------------RDEIQRKFD--------ALRNSCTVIT---------- 572
Cdd:COG4913   509 HLRGRLVYERVRTGLPDPERPRLDPDslagkldfkphpfrawlEAELGRRFDyvcvdspeELRRHPRAITragqvkgngt 588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  573 -------DLEEQLNQLTEDNAELNNQnfyLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQT 645
Cdd:COG4913   589 rhekddrRRIRSRYVLGFDNRAKLAA---LEAELAEL---EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID 662

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  646 MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 725
Cdd:COG4913   663 VASAEREIAELEAELERLDASSDDLAALEEQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEA 738

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  726 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 777
Cdd:COG4913   739 AEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELE 790
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 8-831 4.56e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 4.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     8 KSKELQDSQDKCHKMEQEMTRLHRRVSEVEavLSQKEVELKASETQrslleqdlatyiteCSSLKRSLEQARMEVSQEDD 87
Cdd:TIGR00606  317 KERELVDCQRELEKLNKERRLLNQEKTELL--VEQGRLQLQADRHQ--------------EHIRARDSLIQSLATRLELD 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    88 kALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKV 167
Cdd:TIGR00606  381 -GFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFV 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   168 VShppRGDSGGTALDDLHKMQghAGLTSAKdqgkpevGEYSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQ 247
Cdd:TIGR00606  460 IK---ELQQLEGSSDRILELD--QELRKAE-------RELSKAEKNSLTETLKKEVKSLQNEKA--------DLDRKLRK 519

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   248 AKERAErELEKLHNREDSSEGIKKKLVEAEER------RHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMADKILEL 321
Cdd:TIGR00606  520 LDQEME-QLNHHTTTRTQMEMLTKDKMDKDEQirkiksRHSDE--LTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 596

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   322 EEKHREAQVSAQHLEVHLKQKEQH---YEEKIKvldnqikkDLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsK 398
Cdd:TIGR00606  597 NKELASLEQNKNHINNELESKEEQlssYEDKLF--------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---A 661

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDH 470
Cdd:TIGR00606  662 TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDL 741

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   471 SDKsRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEA 543
Cdd:TIGR00606  742 KEK-EIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDL 820

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   544 EEEIQALTAHRDEIQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 619
Cdd:TIGR00606  821 DRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   620 RREIteremqltSQKQAQLSaPDLQTMEalkttctmleeqvlDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQ 699
Cdd:TIGR00606  901 IREI--------KDAKEQDS-PLETFLE--------------KDQQEKEELISSKET----------SNKKAQDKVNDIK 947

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   700 RMLDTEKQSRARADQRITESRqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL--- 776
Cdd:TIGR00606  948 EKVKNIHGYMKDIENKIQDGK---DDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlr 1024

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828   777 -------ETERELKQRLLE-----------EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 831
Cdd:TIGR00606 1025 krenelkEVEEELKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 302-532 6.24e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 6.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  302 DDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK 381
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  382 GKILSEQKAMINAMdskIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 461
Cdd:COG4942    96 RAELEAQKEELAEL---LRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936828  462 lekishqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 532
Cdd:COG4942   173 -----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 451-798 7.09e-08

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 56.61  E-value: 7.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 530
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   531 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 610
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   611 QLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLE-EQVLD-----LEALNDELLEK-------ERQW 677
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLAElETQLDatrarLRALEGQLAAEqaereraEAQL 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   678 EAWRSVLGDEKSQFECRVRELQ-RMLDTEK---QSRARADQRiTESRQVVELAVKEHKAEILALQQALKEQKLKAESLSD 753
Cdd:pfam19220  233 EEAVEAHRAERASLRMKLEALTaRAAATEQllaEARNQLRDR-DEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQ 311

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 568936828   754 KLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 798
Cdd:pfam19220  312 QFQEMQRARAELEERAEMLTKALAAKDAALERAEERIASLSDRIA 356
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3-406 7.80e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.08  E-value: 7.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    3 KKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAtyitecsslKRSLEQARMEV 82
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQE---------LEALEAELAEL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   83 SQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM----------MNQLEEDLVSARRRSDLYESELRESRLAAEE 152
Cdd:COG4717   145 PERLEELEERLEELRELEEELEELEAELAELQEELEELLeqlslateeeLQDLAEELEELQQRLAELEEELEEAQEELEE 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  153 FKRKANECQHKLMK-------------------VVSHPPRGDSGGTALDDLHKMQ---------GHAGLTSAKDQGKPEV 204
Cdd:COG4717   225 LEEELEQLENELEAaaleerlkearlllliaaaLLALLGLGGSLLSLILTIAGVLflvlgllalLFLLLAREKASLGKEA 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  205 GEYSKLEKINAEQQLKIQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHNREDSSEGIKKKLVEAE 277
Cdd:COG4717   305 EELQALPALEELEEEELEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDE 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  278 ErrhSLENKVKRLEtmerRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhlevhLKQKEQHYEEKIKVLDNQI 357
Cdd:COG4717   385 E---ELRAALEQAE----EYQELKEELEELEEQLEELLGELEELLEALDEEE---------LEEELEELEEELEELEEEL 448

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 568936828  358 KKDLADKESLENMMQRHEEEahekgKILSEQKAMINAMDSKIRSLEQRI 406
Cdd:COG4717   449 EELREELAELEAELEQLEED-----GELAELLQELEELKAELRELAEEW 492
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1078-1197 8.03e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  1078 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1157
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568936828  1158 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1197
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 717-928 9.18e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 9.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  717 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 796
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  797 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 858
Cdd:COG4942    99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  859 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 928
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-614 1.25e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 56.72  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     2 EKKLLIKSKelQDSQDKCHKMEQEMTRLHRRVSEVEAV-------LSQKEVELKASETQRSLLEQDLATYITECSSLKRS 74
Cdd:pfam01576  392 ELRTLQQAK--QDSEHKRKKLEGQLQELQARLSESERQraelaekLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    75 LEQARMEVSQEDDKALQLLHDIR---EQSRKLQEIKEQEYQA--------------------QVEEMRLMMNQLEEDLVS 131
Cdd:pfam01576  470 LQDTQELLQEETRQKLNLSTRLRqleDERNSLQEQLEEEEEAkrnverqlstlqaqlsdmkkKLEEDAGTLEALEEGKKR 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   132 ARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHK----MQGHAGLTSAKDQGKPEVGEY 207
Cdd:pfam01576  550 LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKkfdqMLAEEKAISARYAEERDRAEA 629

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   208 SKLEKINAEQQL-----KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR-EDSSEGIKKKLVEAEERRH 281
Cdd:pfam01576  630 EAREKETRALSLaraleEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRAlEQQVEEMKTQLEELEDELQ 709

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   282 SLENKVKRLE-TMERRENRLKDDIQTKSEQ--------IQQMADKILELEE--KHREAQVSA-QHLEVHLKQKEQHYEEK 349
Cdd:pfam01576  710 ATEDAKLRLEvNMQALKAQFERDLQARDEQgeekrrqlVKQVRELEAELEDerKQRAQAVAAkKKLELDLKELEAQIDAA 789

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   350 IKVLDNQIKKdLADKESLENMMQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNM 427
Cdd:pfam01576  790 NKGREEAVKQ-LKKLQAQMKDLQRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQ 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   428 ---KAQEEMI------SELRQQKFYLETQAGKLEAQNRklEEQLEKISHQDHSDKSRLL--ELETRL---REVSLEHEEQ 493
Cdd:pfam01576  862 erdELADEIAsgasgkSALQDEKRRLEARIAQLEEELE--EEQSNTELLNDRLRKSTLQveQLTTELaaeRSTSQKSESA 939

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   494 KLELKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEI 557
Cdd:pfam01576  940 RQQLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHAD 1019

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936828   558 QRKfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 614
Cdd:pfam01576 1020 QYK-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 208-797 1.34e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 56.77  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   208 SKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNirQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 284
Cdd:pfam12128  290 QLLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEALED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALT 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   285 NKVKRLE-TMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 362
Cdd:pfam12128  368 GKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLG 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   363 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 442
Cdd:pfam12128  448 ELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELEL 527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   443 YLETQAGKLEAQNRKlEEQLEKISHQDHSDKSRLL--ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERE 512
Cdd:pfam12128  528 QLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrtDLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERL 606

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   513 SQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNsctvitdLEEQLNQLTEDNAEL 588
Cdd:pfam12128  607 DKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQS-------EKDKKNKALAERKDS 679

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   589 NNQNFylsKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQAQLSAPDLQtMEALKTTCTMLEEQvldLEALND 668
Cdd:pfam12128  680 ANERL---NSLEAQLKQLDKKHQAWLE--EQKEQKREARTEKQAYWQVVEGALDAQ-LALLKAAIAARRSG---AKAELK 750

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   669 ELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKA 748
Cdd:pfam12128  751 ALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNI 819

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568936828   749 ESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQQQM 797
Cdd:pfam12128  820 ER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENLRGLRCEM 869
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 365-947 1.43e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.52  E-value: 1.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   365 ESLENMMQRHEEEAHEKGKILSEQ--------KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMiSE 436
Cdd:TIGR00618  179 TQLALMEFAKKKSLHGKAELLTLRsqlltlctPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-LK 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlt 516
Cdd:TIGR00618  258 KQQLLKQLRARIEELRAQEAVLEETQERINRARK--AAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA---- 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   517 ALQAARAALESQLRQAKTELEETTAEAEEEIQALT--AHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 594
Cdd:TIGR00618  332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSirEISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQAT 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   595 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTctMLEEQVLDLEALNDELLEKE 674
Cdd:TIGR00618  412 IDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLK--EREQQLQTKEQIHLQETRKK 489

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   675 RQWEAWRSVLGDEKSQFECRVREL--QRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLS 752
Cdd:TIGR00618  490 AVVLARLLELQEEPCPLCGSCIHPnpARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQ 569

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   753 DKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKL---QQQMDLQKN---HIFRLTQGLQEALDRADLLKT--- 823
Cdd:TIGR00618  570 QSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTalh 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   824 -ERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR----RKEDPALPTQVPlQYNELKLA 898
Cdd:TIGR00618  650 aLQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtllRELETHIEEYDR-EFNEIENA 726

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 568936828   899 LEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 947
Cdd:TIGR00618  727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
597-843 1.60e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  597 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQ 676
Cdd:COG4913   252 ELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLE----AELEELRAELARLEAELERLEARLDALREELDE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  677 WE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQVVELAVKEHKAEILALQQALKEQKLKAESLSDKl 755
Cdd:COG4913   328 LEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AALGLPLPASAEEFAALRAEAAALLEALEEELEA- 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  756 ndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR-ADLLKTERSDLEYQLEN 834
Cdd:COG4913   403 ----------------LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAlAEALGLDEAELPFVGEL 466


                  ....*....
gi 568936828  835 IQVLYSHEK 843
Cdd:COG4913   467 IEVRPEEER 475
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 88-925 1.80e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 56.21  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    88 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQ 161
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   162 HKLMKVVShpprgdsggtaLDDlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 241
Cdd:TIGR00606  259 HNLSKIMK-----------LDN----------------------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLND 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   242 LQNIRQAKERA--------ERELEKLhNREDSSEGIKKKLVEAEERRHSLenKVKRLETMERRENRLKDDIQTKSE---- 309
Cdd:TIGR00606  306 LYHNHQRTVREkerelvdcQRELEKL-NKERRLLNQEKTELLVEQGRLQL--QADRHQEHIRARDSLIQSLATRLEldgf 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   310 ----------------QIQQMADK-------ILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLAD 363
Cdd:TIGR00606  383 ergpfserqiknfhtlVIERQEDEaktaaqlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEkkqEELKFVIKE 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   364 KESLENMMQRHEEEAHEKGKILSE-QKAMINA------------------MDSKIRSLEQRIVELSEANKLAANSSLFTQ 424
Cdd:TIGR00606  463 LQQLEGSSDRILELDQELRKAERElSKAEKNSltetlkkevkslqnekadLDRKLRKLDQEMEQLNHHTTTRTQMEMLTK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   425 RNMKAQEEMISELRQQKFYLETQAGKLeAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRqLTEL 504
Cdd:TIGR00606  543 DKMDKDEQIRKIKSRHSDELTSLLGYF-PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES-KEEQ 620

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   505 QLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDE-------IQRKFDALRNSCTVITDL 574
Cdd:TIGR00606  621 LSSYEDKLFDVCGSQDEESDLERlkeEIEKSSKQRAMLAGATAVYSQFITQLTDEnqsccpvCQRVFQTEAELQEFISDL 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   575 EEQLNQLTEDNAELNNQNFYLSKQLDEASG-----------ANDEIVQLRSEVDHLRREITEREMQLTSQ-KQAQLSAPD 642
Cdd:TIGR00606  701 QSKLRLAPDKLKSTESELKKKEKRRDEMLGlapgrqsiidlKEKEIPELRNKLQKVNRDIQRLKNDIEEQeTLLGTIMPE 780

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   643 LQTMEALKTTCTMLEEQVLDLE-----------------------ALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ 699
Cdd:TIGR00606  781 EESAKVCLTDVTIMERFQMELKdverkiaqqaaklqgsdldrtvqQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQ 860

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   700 RM------LDTEK--------QSRARADQRITESRQVVEL--AVKEHKAEILALQQALKEQKLKAESL-----------S 752
Cdd:TIGR00606  861 HLksktneLKSEKlqigtnlqRRQQFEEQLVELSTEVQSLirEIKDAKEQDSPLETFLEKDQQEKEELissketsnkkaQ 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   753 DKLNDLEKKHAMLEMNARSLQQKLE--TERELKQRlLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 830
Cdd:TIGR00606  941 DKVNDIKEKVKNIHGYMKDIENKIQdgKDDYLKQK-ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQD 1019

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   831 QL----------ENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqvplqYNELKLALE 900
Cdd:TIGR00606 1020 NLtlrkrenelkEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKG-----------YEKEIKHFK 1088

                          970       980
                   ....*....|....*....|....*..
gi 568936828   901 KE--KARCAELEEALQKTRIELRSARE 925
Cdd:TIGR00606 1089 KElrEPQFRDAEEKYREMMIVMRTTEL 1115
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 416-641 2.49e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 2.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  416 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL 495
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  496 ELKRQLTELQ-----LSLQERESQLTALQAARAALESQ-----LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR 565
Cdd:COG4942    98 ELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  566 nscTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAP 641
Cdd:COG4942   178 ---ALLAELEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
557-798 2.68e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.41  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  557 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 630
Cdd:COG3206   166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  631 tSQKQAQLSAPDLQTMEALKTTctmleeqvlDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRA 710
Cdd:COG3206   243 -AALRAQLGSGPDALPELLQSP---------VIQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQ 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  711 RADQRITESRQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE-- 788
Cdd:COG3206   309 QEAQRILASLEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrl 374

                         250
                  ....*....|
gi 568936828  789 EQAKLQQQMD 798
Cdd:COG3206   375 EEARLAEALT 384
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1078-1197 2.96e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.96e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   1078 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1157
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 568936828   1158 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1197
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 7-649 3.42e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 55.36  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     7 IKSKELQDSQdKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:TIGR00618  370 ISCQQHTLTQ-HIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRtsaFRDLQGQLAHAKKQQELQQRYAELCAAAIT 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    84 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQVeemrlmmnqleedlvsarrrsdlyeSELRESRLAAEEFKR----KANE 159
Cdd:TIGR00618  449 CTAQCEKLEKIHLQESAQSLKEREQQLQTKEQ-------------------------IHLQETRKKAVVLARllelQEEP 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   160 CQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEAT 239
Cdd:TIGR00618  504 CPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSK 583

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   240 ELLQNIRQAKERAERELEKLHNREDSSEGIKKKlvEAEERRHSLENKVKRLEtmerrenrlkddiqtkseqiQQMADKIL 319
Cdd:TIGR00618  584 EDIPNLQNITVRLQDLTEKLSEAEDMLACEQHA--LLRKLQPEQDLQDVRLH--------------------LQQCSQEL 641

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   320 ELEEKHREaqvsaQHLEVHLKQKEQHYEEKIKVldnqikkdlaDKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 399
Cdd:TIGR00618  642 ALKLTALH-----ALQLTLTQERVREHALSIRV----------LPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLL 706

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   400 RSLEQRIVELSEanklaansslftqrnmkaqeemisELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQdhsdKSRLLEL 479
Cdd:TIGR00618  707 RELETHIEEYDR------------------------EFNEIENASSSLGSDLAAREDALNQSLKELMHQ----ARTVLKA 758

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   480 ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQaltAHRDEIQR 559
Cdd:TIGR00618  759 RTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLV---QEEEQFLS 835

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   560 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV----------DHLRREITEREMQ 629
Cdd:TIGR00618  836 RLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDAlikflheitlYANVRLANQSEGR 915

                          650       660
                   ....*....|....*....|
gi 568936828   630 LTSQKQAQLSAPDLQTMEAL 649
Cdd:TIGR00618  916 FHGRYADSHVNARKYQGLAL 935
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
11-531 3.97e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 3.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKA-------SETQRSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:PRK02224  259 EIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDllaeaglDDADAEAVEARREELEDRDEELRDRLEECRVAAQ 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   84 QEDDKALQLLHDIREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 154
Cdd:PRK02224  339 AHNEEAESLREDADDLEERAEELREeaaeleselEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELR 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  155 RKANECQHKLMKVVShpprgdSGGTALDDLHKMQghagltSAKDQGK-PEVG---EYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:PRK02224  419 EERDELREREAELEA------TLRTARERVEEAE------ALLEAGKcPECGqpvEGSPHVETIEEDRERVEELEAELED 486

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  231 AvkasteatellqnirqakERAERELEKLHNRedssegiKKKLVEAEERRHSLENKVKRLEtmERRENRlKDDIQTKSEQ 310
Cdd:PRK02224  487 L------------------EEEVEEVEERLER-------AEDLVEAEDRIERLEERREDLE--ELIAER-RETIEEKRER 538

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  311 IQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENmmqrheeeahekgkiLSEQKA 390
Cdd:PRK02224  539 AEELRERAAELEAEAEEKREAAAEAE----EEAEEAREEVAELNSKLAELKERIESLER---------------IRTLLA 599

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  391 MINAMDSKIRSLEQRIVELSEAN-----KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 465
Cdd:PRK02224  600 AIADAEDEIERLREKREALAELNderreRLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDL 679

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  466 SHQDHSDKSRLLELEtRLREvslEHEEqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQ 531
Cdd:PRK02224  680 QAEIGAVENELEELE-ELRE---RREA--------LENRVEALEALYDEAEELESMYGDLRAELRQ 733
mukB PRK04863
chromosome partition protein MukB;
246-627 4.15e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 55.35  E-value: 4.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  246 RQAKERAERELEKLHNREDSSeGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------EQIQ 312
Cdd:PRK04863  276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  313 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKIL 385
Cdd:PRK04863  352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  386 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 460
Cdd:PRK04863  424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  461 QLEKISHQDhsdkSRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 537
Cdd:PRK04863  504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  538 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 617
Cdd:PRK04863  579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658

                         410
                  ....*....|
gi 568936828  618 HLRREITERE 627
Cdd:PRK04863  659 EEIERLSQPG 668
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 219-368 6.54e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 6.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  219 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRedsSEGIKKKLVEAEERRHSLENKVKRLET--MERR 296
Cdd:COG1579    10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  297 ENR----LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 368
Cdd:COG1579    87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 206-368 6.66e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAeerrhsleN 285
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  286 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 365
Cdd:COG1579    87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                  ...
gi 568936828  366 SLE 368
Cdd:COG1579   167 ELA 169
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 362-565 1.11e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  362 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQk 441
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  442 fyLETQAGKLEAQNRKL-----EEQLEKISHQDHSDKS------------RLLELETRLREVSLEHEEQKLELKRQLTEL 504
Cdd:COG4942    99 --LEAQKEELAELLRALyrlgrQPPLALLLSPEDFLDAvrrlqylkylapARREQAEELRADLAELAALRAELEAERAEL 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568936828  505 QLSLQERESQLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHRDEIQRKFDALR 565
Cdd:COG4942   177 EALLAELEEERAALEALKAERQKLLARLE----KELAELAAELAELQQEAEELEALIARLE 233
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 211-870 1.35e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.51  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   211 EKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKR 289
Cdd:TIGR00606  177 EIFSATRYIKALETLRQVRQTQGQKVQEHQMeLKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKE 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   290 LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVHLKQKEQHYEEKIKvldnQIKKDLAD-KESLE 368
Cdd:TIGR00606  257 IEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKV---FQGTDEQLNDLYHNHQRTVR----EKERELVDcQRELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   369 NMMQRHEEEAHEKGKILSEQKAM----------INAMDSKIRSLEQR-----------------------IVELSEANKL 415
Cdd:TIGR00606  330 KLNKERRLLNQEKTELLVEQGRLqlqadrhqehIRARDSLIQSLATRleldgfergpfserqiknfhtlvIERQEDEAKT 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   416 AANSSLFTQRNMKAQEEMISELRQQKFYLetqAGKLEAQNRKLEEQLEKISH------QDHSDKSRLLELETRL----RE 485
Cdd:TIGR00606  410 AAQLCADLQSKERLKQEQADEIRDEKKGL---GRTIELKKEILEKKQEELKFvikelqQLEGSSDRILELDQELrkaeRE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   486 VSLEHEEQKLE-LKRQLTELQL----------SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH- 553
Cdd:TIGR00606  487 LSKAEKNSLTEtLKKEVKSLQNekadldrklrKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLl 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   554 ----------------RDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 617
Cdd:TIGR00606  567 gyfpnkkqledwlhskSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKE 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   618 HLRREITEREM-------------QLTSQKQA--QLSAPDLQTMEALKTTCTMLEEQVL----DLEALNDELLEKERQWE 678
Cdd:TIGR00606  647 EIEKSSKQRAMlagatavysqfitQLTDENQSccPVCQRVFQTEAELQEFISDLQSKLRlapdKLKSTESELKKKEKRRD 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   679 AWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAEIL--------ALQQALKEQKL 746
Cdd:TIGR00606  727 EMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAKVCltdvtimeRFQMELKDVER 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   747 KAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 821
Cdd:TIGR00606  807 KIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQF 886

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 568936828   822 KTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 870
Cdd:TIGR00606  887 EEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 373-774 1.55e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 53.42  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  373 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 447
Cdd:COG3096   275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  448 AGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 527
Cdd:COG3096   353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  528 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 604
Cdd:COG3096   424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  605 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQAQLSAPDLQTMEALK-TTCTMLEEQVLDLEALNDELLEK 673
Cdd:COG3096   493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQlDAAEELEELLAELEAQLEELEEQ 572

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  674 ERQWEAWRSVLGDEKSQFECRVRELQrmlDTEKQSRArADQRITESRQVVELAVkEHKAEILALQQALKEQKLKAESLSD 753
Cdd:COG3096   573 AAEAVEQRSELRQQLEQLRARIKELA---ARAPAWLA-AQDALERLREQSGEAL-ADSQEVTAAMQQLLEREREATVERD 647

                         410       420
                  ....*....|....*....|.
gi 568936828  754 KLndLEKKHAmLEMNARSLQQ 774
Cdd:COG3096   648 EL--AARKQA-LESQIERLSQ 665
mukB PRK04863
chromosome partition protein MukB;
94-950 1.68e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.04  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   94 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQL---------EEDLVSARRRsdLYES-----ELRESRLAAEEF 153
Cdd:PRK04863  307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALrqqekieryQADLEELEER--LEEQnevveEADEQQEENEAR 384

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  154 KRKANECQHKLMKVVSHPPRgdsggtALDDLHKM-----QGHAGLTSAKDQ-GKPEVgEYSKLEKINAEQQLKIQELQEK 227
Cdd:PRK04863  385 AEAAEEEVDELKSQLADYQQ------ALDVQQTRaiqyqQAVQALERAKQLcGLPDL-TADNAEDWLEEFQAKEQEATEE 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  228 L----------EKAVKASTEATELLQNI----------RQAKErAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:PRK04863  458 LlsleqklsvaQAAHSQFEQAYQLVRKIagevsrseawDVARE-LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE 536

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE-------------KIKVLD 354
Cdd:PRK04863  537 RLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRlaarapawlaaqdALARLR 616

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  355 NQIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMINAmdsKIRSLEQRIVELSEANklaaNSSLFTQRNMKAQ--EE 432
Cdd:PRK04863  617 EQSGEEFEDSQDVTEYMQQLLERERE----LTVERDELAA---RKQALDEEIERLSQPG----GSEDPRLNALAERfgGV 685

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  433 MISELR-----QQKFYLETQAGK---------LEAQNRKLEEQlekishQDHSDKSRLLELE-TRLREVSLEHEEQKLEL 497
Cdd:PRK04863  686 LLSEIYddvslEDAPYFSALYGParhaivvpdLSDAAEQLAGL------EDCPEDLYLIEGDpDSFDDSVFSVEELEKAV 759

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  498 KRQLTELQLslqeRESQLTALQA-ARAALESQLRQakteleettaeaeeeiqaLTAHRDEIQRKFDALRNSCTVITDLEE 576
Cdd:PRK04863  760 VVKIADRQW----RYSRFPEVPLfGRAAREKRIEQ------------------LRAEREELAERYATLSFDVQKLQRLHQ 817

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  577 QLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTCTML 656
Cdd:PRK04863  818 AFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGLSAL 877

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  657 EE-----QVLDLEALNDELLEKERQW----EAWRSVlgdekSQFECRVRELQRMLDTEKQSRARADQritesrqvVELAV 727
Cdd:PRK04863  878 NRllprlNLLADETLADRVEEIREQLdeaeEAKRFV-----QQHGNALAQLEPIVSVLQSDPEQFEQ--------LKQDY 944

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  728 KEHKAEILALQQ---ALKE--QKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDlQKN 802
Cdd:PRK04863  945 QQAQQTQRDAKQqafALTEvvQRRAHFSYEDAAEMLAKNSDLNE----KLRQRLEQAEQERTRAREQLRQAQAQLA-QYN 1019

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  803 HIFrltQGLQEALDRAdllKTERSDLEYQLENIQVLYshekvkmegtisqqtklidflqakmDQPAKKKkglfSRRKEDp 882
Cdd:PRK04863 1020 QVL---ASLKSSYDAK---RQMLQELKQELQDLGVPA-------------------------DSGAEER----ARARRD- 1063

                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  883 alptqvplqynELKLALEKEKARCAELEEALQKTRIELRSA--REEAAHRKATDHPHPSTPATARQQIAM 950
Cdd:PRK04863 1064 -----------ELHARLSANRSRRNQLEKQLTFCEAEMDNLtkKLRKLERDYHEMREQVVNAKAGWCAVL 1122
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 388-660 1.91e-06

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 53.13  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  388 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 465
Cdd:PRK10929   43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  466 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 538
Cdd:PRK10929  115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  539 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 615
Cdd:PRK10929  194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  616 vdhLRREITE------REMQLTSQKQAQLSAPDLQTMEALKTtctmLEEQV 660
Cdd:PRK10929  266 ---INRELSQalnqqaQRMDLIASQQRQAASQTLQVRQALNT----LREQS 309
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 992-1047 1.99e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.99e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828   992 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1047
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 708-985 2.25e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  708 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 785
Cdd:COG3883    10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  786 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 862
Cdd:COG3883    86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  863 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 942
Cdd:COG3883   141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 568936828  943 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 985
Cdd:COG3883   221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 214-922 2.35e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 52.52  E-value: 2.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   214 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 293
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   294 ERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 360
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   361 LADKESLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 439
Cdd:pfam10174  209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   440 QKFYletqagkleaqnrkleeqlekishQDHSDKsrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam10174  277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   520 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 592
Cdd:pfam10174  310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   593 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdLQTMEALKTTCtmleeqvldLEALNDELLE 672
Cdd:pfam10174  383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKS---LQTDSSNTDTA---------LTTLEEALSE 447

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   673 KERQWEAWRsvlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA 748
Cdd:pfam10174  448 KERIIERLK-----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKS 521

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   749 ---------ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAld 816
Cdd:pfam10174  522 leiaveqkkEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-- 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   817 radllKTERSDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELK 896
Cdd:pfam10174  592 -----ENEKNDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQ 654

                          730       740
                   ....*....|....*....|....*.
gi 568936828   897 LALEkekarcaELEEALQKTRIELRS 922
Cdd:pfam10174  655 LQLE-------ELMGALEKTRQELDA 673
PRK01156 PRK01156
chromosome segregation protein; Provisional
 30-439 2.55e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   30 HRRVSEVEAVLSQKEVELKASETQRSLLEqDLATYITECSSLKRSLEQARMEVsQEDDKALQLLHDIREQSRKLQEIKEQ 109
Cdd:PRK01156  328 IKKLSVLQKDYNDYIKKKSRYDDLNNQIL-ELEGYEMDYNSYLKSIESLKKKI-EEYSKNIERMSAFISEILKIQEIDPD 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  110 EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR------------------LAAEEFKRKANECQHKLMKVVSHP 171
Cdd:PRK01156  406 AIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSrnmemlngqsvcpvcgttLGEEKSNHIINHYNEKKSRLEEKI 485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  172 PRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAE---QQLKIQELQEKLEKAVKASTEATEL-LQNIRQ 247
Cdd:PRK01156  486 REIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADledIKIKINELKDKHDKYEEIKNRYKSLkLEDLDS 565

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  248 AKER-----AERELEKLHNREDSSEGIKKKLVEAEERRHSLE-----------NKVKRLETMERRENRLKDDIQTKSEQI 311
Cdd:PRK01156  566 KRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEigfpddksyidKSIREIENEANNLNNKYNEIQENKILI 645

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  312 QQMADKILELEE---KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDnQIKKDLADKESLENMMQRHEEEahekgkiLSEQ 388
Cdd:PRK01156  646 EKLRGKIDNYKKqiaEIDSIIPDLKEITSRINDIEDNLKKSRKALD-DAKANRARLESTIEILRTRINE-------LSDR 717

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  389 KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQ 439
Cdd:PRK01156  718 INDINETLESMKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTSLTRK 768
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 602-930 3.60e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.15  E-value: 3.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   602 ASGANDEIVQL-----RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALkttctMLEEQVLDLEALNDELLEKERQ 676
Cdd:pfam12128  204 AILEDDGVVPPksrlnRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNTLESA-----ELRLSHLHFGYKSDETLIASRQ 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   677 wEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 756
Cdd:pfam12128  279 -EERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   757 DLEKKHAMLEMNARSLQQKLETEREL-KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENI 835
Cdd:pfam12128  358 NLEERLKALTGKHQDVTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAG 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   836 QVLYSHEKVKMEGTISQQTKLIDFLQAkmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQK 915
Cdd:pfam12128  432 KLEFNEEEYRLKSRLGELKLRLNQATA------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQS 492

                          330
                   ....*....|....*
gi 568936828   916 TRIELRSAREEAAHR 930
Cdd:pfam12128  493 ELRQARKRRDQASEA 507
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 429-665 4.08e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.92  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  429 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSL 508
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  509 QERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 588
Cdd:COG4942    93 AELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAEL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828  589 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQlsapdLQTMEALKTTCTMLEEQVLDLEA 665
Cdd:COG4942   163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAEL-----AAELAELQQEAEELEALIARLEA 234
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
298-836 6.18e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  298 NRLKDDiqtKSEQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 377
Cdd:PRK02224  179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  378 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 457
Cdd:PRK02224  250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  458 LEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 537
Cdd:PRK02224  295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  538 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 615
Cdd:PRK02224  367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  616 VDHLRreitEREMQLTSqkqaqlsapDLQTMEalkttcTMLEEqvldlealNDELLEKERQWEAWRSVLG----DEKSQF 691
Cdd:PRK02224  421 RDELR----EREAELEA---------TLRTAR------ERVEE--------AEALLEAGKCPECGQPVEGsphvETIEED 473

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  692 ECRVRELQRMLDTEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEM 767
Cdd:PRK02224  474 RERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEA 551

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  768 NARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 836
Cdd:PRK02224  552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 548-777 6.59e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  548 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITERE 627
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAAL---ARRIRALEQELAALEAELAELE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  628 MQLtSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQ 707
Cdd:COG4942    90 KEI-AELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAA 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  708 SRaradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 777
Cdd:COG4942   165 LR----AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 239-584 7.77e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.45  E-value: 7.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   239 TELLQNIRQAKERAErELEKLHNRE-DSSEGIKKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSEQIQQMAD 316
Cdd:pfam19220   37 EAILRELPQAKSRLL-ELEALLAQErAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRD 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   317 KILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMD 396
Cdd:pfam19220  116 KTAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELT 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   397 SKIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishq 468
Cdd:pfam19220  195 RRLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------ 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   469 dhsdksrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQ 548
Cdd:pfam19220  264 -------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTK 332

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 568936828   549 ALTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 584
Cdd:pfam19220  333 ALAAKD-------AALERAEERIASLSDRIAELTKR 361
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 602-873 9.01e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 9.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  602 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDlqtmealkttctmleeqvlDLEALNDELLEKERQweawr 681
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-------------------QLAALERRIAALARR----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  682 svlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 761
Cdd:COG4942    71 -------------IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRR 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  762 HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSH 841
Cdd:COG4942   138 LQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAA 213

                         250       260       270
                  ....*....|....*....|....*....|..
gi 568936828  842 EKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG 873
Cdd:COG4942   214 ELAELQQEAEELEALIARLEAEAAAAAERTPA 245
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 571-802 1.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  571 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREI--TEREMQLTSQKQAQLSAPdlqtMEA 648
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIraLEQELAALEAELAELEKE----IAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  649 LKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVK 728
Cdd:COG4942    95 LRAE---LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRA 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568936828  729 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 802
Cdd:COG4942   168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 207-641 1.04e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.51  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   207 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHS---- 282
Cdd:pfam05557    6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREqael 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   283 LENKVKRLETMERRENRlKDDIQTKSEQIQ------------QMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKI 350
Cdd:pfam05557   78 NRLKKKYLEALNKKLNE-KESQLADAREVIsclknelselrrQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLR 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   351 KVLDNQiKKDLADKE----SLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ-- 424
Cdd:pfam05557  156 QNLEKQ-QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEev 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   425 --------RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQDHSDKSRLLELETRLREVS 487
Cdd:pfam05557  231 edlkrkleREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSARQLE 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   488 ---LEHEEQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQ 548
Cdd:pfam05557  311 karRELEQELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   549 ALTAHRDEIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREIT 624
Cdd:pfam05557  391 KMQAHNEEMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKN 465

                          490
                   ....*....|....*..
gi 568936828   625 EREMQLTSQKQAQLSAP 641
Cdd:pfam05557  466 ELEMELERRCLQGDYDP 482
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1554-1645 1.35e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1554 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1617
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                          90       100       110
                  ....*....|....*....|....*....|
gi 568936828 1618 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1645
Cdd:PTZ00449  607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
382-818 1.43e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 49.99  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  382 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 461
Cdd:COG5281     3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  462 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 541
Cdd:COG5281    83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  542 EAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 621
Cdd:COG5281   160 AAAAAAAAAAAAAAAAAAALAAASAA-----AAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQ 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  622 EITEREMQLTSQKQAQLSapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRM 701
Cdd:COG5281   235 AALAAASAAAQALAALAA--AAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  702 LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERE 781
Cdd:COG5281   310 AAQLAAAAAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAG 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 568936828  782 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 818
Cdd:COG5281   385 AKAALAEYADSATNVAAQVAQAATSAFSGLTDALAGA 421
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
549-927 1.45e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.04  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  549 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 628
Cdd:PRK02224  188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  629 QLTSqkqaqlsapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS 708
Cdd:PRK02224  266 TIAE---------TEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  709 -----------RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 777
Cdd:PRK02224  337 aqahneeaeslREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLE 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  778 TERELKQRLLEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshE 842
Cdd:PRK02224  416 ELREERDELREREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----E 490

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  843 KVKMEGTISQQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRS 922
Cdd:PRK02224  491 VEEVEERLERAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAE 562


                  ....*
gi 568936828  923 AREEA 927
Cdd:PRK02224  563 AEEEA 567
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
208-563 1.62e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  208 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEERRHSLENKV 287
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESL 367
Cdd:COG4372    94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 447
Cdd:COG4372   170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  448 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 527
Cdd:COG4372   250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 568936828  528 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 563
Cdd:COG4372   330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 492-763 1.76e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  492 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 571
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  572 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEivQLRSevdHLRREITEREMQLTSQKQAQLSAPDLQTMEALKT 651
Cdd:COG4942    73 -ALEQELAALEAELAELEKEIAELRAELEAQKEELAE--LLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  652 TctmLEEQVLDLEALNDELLEKERQWEAWRsvlgdeksqfecrvRELQRMLDTEKQSRARADQRITESRQVvelaVKEHK 731
Cdd:COG4942   147 A---RREQAEELRADLAELAALRAELEAER--------------AELEALLAELEEERAALEALKAERQKL----LARLE 205

                         250       260       270
                  ....*....|....*....|....*....|..
gi 568936828  732 AEILALQQALKEQKLKAESLSDKLNDLEKKHA 763
Cdd:COG4942   206 KELAELAAELAELQQEAEELEALIARLEAEAA 237
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 388-591 1.81e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  388 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 467
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  468 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 540
Cdd:COG4942    98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  541 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 591
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 9-280 1.89e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    9 SKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDK 88
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   89 ALQLLHDIREQSRKLQEIKEQEYqaqveeMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvv 168
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRQPP------LALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE--------- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  169 shpprgdsggtalddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 248
Cdd:COG4942   162 ------------------------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKE 207

                         250       260       270
                  ....*....|....*....|....*....|..
gi 568936828  249 KERAERELEKLHNREDSSEGIKKKLVEAEERR 280
Cdd:COG4942   208 LAELAAELAELQQEAEELEALIARLEAEAAAA 239
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 996-1046 2.05e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 2.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  996 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1046
Cdd:cd20824     1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
mukB PRK04863
chromosome partition protein MukB;
296-812 2.58e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  296 RENRLKD---DIQTKSEQIQQMADKILELEEKHREA-QVSAQHLEVHLkqkEQHYEEKIKVLD---NQIKKDLADKESLE 368
Cdd:PRK04863  784 REKRIEQlraEREELAERYATLSFDVQKLQRLHQAFsRFIGSHLAVAF---EADPEAELRQLNrrrVELERALADHESQE 860

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  369 nmmQRHEEEAhekgKILSEQKAMINAMDSKIR-----SLEQRIVELSEANKLAANSSLFTQRNMKA-------------Q 430
Cdd:PRK04863  861 ---QQQRSQL----EQAKEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAlaqlepivsvlqsD 933

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  431 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTELQL 506
Cdd:PRK04863  934 PEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQA 1013

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  507 SLQERESQLTALQAARAALESQLRQAKTELEET-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdn 585
Cdd:PRK04863 1014 QLAQYNQVLASLKSSYDAKRQMLQELKQELQDLgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE-- 1087

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  586 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTMeALKttctmleeqvlDL 663
Cdd:PRK04863 1088 AEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNgvERRLHRRELAYLSADELRSM-SDK-----------AL 1155

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  664 EAL------NDELLEKERQWEAWRSVlgDEKSQFECRVRELQRmldtekqSRARADqrITESRQVVElavkehkaeilAL 737
Cdd:PRK04863 1156 GALrlavadNEHLRDVLRLSEDPKRP--ERKVQFYIAVYQHLR-------ERIRQD--IIRTDDPVE-----------AI 1213

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  738 QQalkeqklkaesLSDKLNDLEKkhamlEMNARslQQKLETERElkqrllEEQAKLQQQMDLQKNHIFRLTQGLQ 812
Cdd:PRK04863 1214 EQ-----------MEIELSRLTE-----ELTSR--EQKLAISSE------SVANIIRKTIQREQNRIRMLNQGLQ 1264
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 339-532 2.81e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  339 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSEANK 414
Cdd:COG3883    28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEErreeLGERARALYRSGGSVSYLDV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  415 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 486
Cdd:COG3883   108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 568936828  487 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 532
Cdd:COG3883   174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
COG5022 COG5022
Myosin heavy chain [General function prediction only];
221-840 2.95e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.31  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  221 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKKlVEAEERRHSLENKVKRLETMERRENRL 300
Cdd:COG5022   819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKR-FSLLKKETIYLQSAQRVELAERQLQEL 887

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  301 KDDIqtksEQIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKESLENMMQRHEEE 377
Cdd:COG5022   888 KIDV----KSISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  378 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 455
Cdd:COG5022   964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  456 RKLEE--QLEKISHQDHSDKSRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 533
Cdd:COG5022  1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  534 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 613
Cdd:COG5022  1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  614 SEVDHLRREITEREMQLTSQKQAQLSApdlqtmeALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFE 692
Cdd:COG5022  1160 FWEANLEALPSPPPFAALSEKRLYQSA-------LYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISE 1229

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  693 CRVRELQRMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----L 765
Cdd:COG5022  1230 GWVPTEYSTSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaL 1301

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  766 EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 840
Cdd:COG5022  1302 RTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 328-552 3.04e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  328 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 407
Cdd:COG3883     3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  408 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 482
Cdd:COG3883    83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  483 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 552
Cdd:COG3883   152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
224-440 3.14e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  224 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS-------------EGIKKKLVEAEERRHSLENKVKRL 290
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVdlseeaklllqqlSELESQLAEARAELAEAEARLAAL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  291 ETMERRENRLKDDIQTkSEQIQQMADKILELEEkhREAQVSAQHLEVHlkqkeqhyeEKIKVLDNQIkkdladkESLENM 370
Cdd:COG3206   246 RAQLGSGPDALPELLQ-SPVIQQLRAQLAELEA--ELAELSARYTPNH---------PDVIALRAQI-------AALRAQ 306

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828  371 MQRheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFT--QRNMKAQEEMISELRQQ 440
Cdd:COG3206   307 LQQ------EAQRILASLEAELEALQAREASLQAQLAQLeARLAELPELEAELRrlEREVEVARELYESLLQR 373
PRK11281 PRK11281
mechanosensitive channel MscK;
483-809 3.99e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.75  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  483 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 559
Cdd:PRK11281   48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  560 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQK-- 634
Cdd:PRK11281  116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLkg 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  635 ----QAQLSAPDLQTMEAlkttctmleEQVLdLEALNDEllekERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrA 710
Cdd:PRK11281  182 gkvgGKALRPSQRVLLQA---------EQAL-LNAQNDL----QRKSLEGNTQLQD--------LLQKQRDYLTARI--Q 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  711 RADQRITESRQVV---ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLL 787
Cdd:PRK11281  238 RLEHQLQLLQEAInskRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLL 295

                         330       340
                  ....*....|....*....|....*
gi 568936828  788 EEQAKLQQ--QMDLQ-KNHIFRLTQ 809
Cdd:PRK11281  296 KATEKLNTltQQNLRvKNWLDRLTQ 320
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 283-464 5.48e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 5.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  283 LENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 358
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  359 -----------------KDLADKESLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 421
Cdd:COG3883    98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 568936828  422 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 464
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 531-809 5.51e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 47.11  E-value: 5.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   531 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANdEIV 610
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVN-ELL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   611 QLRSEVDHLRREITEREMQLT------SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrsvl 684
Cdd:pfam15905  142 KAKFSEDGTQKKMSSLSMELMklrnklEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKI------ 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   685 gDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAM 764
Cdd:pfam15905  216 -EEKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQIKDLNEKCKL 286

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 568936828   765 LEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 809
Cdd:pfam15905  287 LE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 394-563 5.62e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  394 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 473
Cdd:COG1579    14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  474 SRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 541
Cdd:COG1579    73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                         170       180
                  ....*....|....*....|..
gi 568936828  542 EAEEEIQALTAHRDEIQRKFDA 563
Cdd:COG1579   153 ELEAELEELEAEREELAAKIPP 174
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 195-397 6.41e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  195 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 274
Cdd:COG3883    13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  275 EAEERR-------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQ 341
Cdd:COG3883    93 RALYRSggsvsyldvllgsESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  342 KEQHYEEK---IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 397
Cdd:COG3883   173 LEAQQAEQealLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 996-1047 6.65e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.10  E-value: 6.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568936828  996 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 1047
Cdd:cd20798     1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 300-709 6.92e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 47.87  E-value: 6.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  300 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESLEnmmqrheeEAH 379
Cdd:PRK10246  424 LRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQE 487

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  380 EKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrk 457
Cdd:PRK10246  488 ARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA---- 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  458 LEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQ 514
Cdd:PRK10246  556 LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQ 631

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  515 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR------KFDALRNSCTVITDLEEQLNQLTEDNAEL 588
Cdd:PRK10246  632 IIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSwqqrqnELTALQNRIQQLTPLLETLPQSDDLPHSE 711

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  589 NnqnfylSKQLDEASGANDEIVQLRSEVDHLRREITErEMQLTSQKQAQLSApdlqtmeALKTTCtmLEEQVLDLEALND 668
Cdd:PRK10246  712 E------TVALDNWRQVHEQCLSLHSQLQTLQQQDVL-EAQRLQKAQAQFDT-------ALQASV--FDDQQAFLAALLD 775

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 568936828  669 EllEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR 709
Cdd:PRK10246  776 E--ETLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHR 814
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
10-408 7.09e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARmevsqeddka 89
Cdd:PRK02224  370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTAR---------- 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   90 lqllHDIREQSRKL---------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAEEFKRKANEC 160
Cdd:PRK02224  440 ----ERVEEAEALLeagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AEDLVEAEDRI 511

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  161 QHKLMKVvshpprgdsggtalDDLHKM--QGHAGLTSAKDQgkpevgeyskLEKINAEQQlkiqELQEKLEKAVKASTEA 238
Cdd:PRK02224  512 ERLEERR--------------EDLEELiaERRETIEEKRER----------AEELRERAA----ELEAEAEEKREAAAEA 563

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  239 TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKI 318
Cdd:PRK02224  564 EEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEF 643

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  319 LE--LEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE--EEAHEKGKILSEQKAMINA 394
Cdd:PRK02224  644 DEarIEEAREDKERAEEYLE-QVEEKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELES 722

                         410
                  ....*....|....*
gi 568936828  395 MDSKIRS-LEQRIVE 408
Cdd:PRK02224  723 MYGDLRAeLRQRNVE 737
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1079-1124 7.12e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568936828 1079 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1124
Cdd:cd01242     2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 556-865 7.53e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 47.64  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  556 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITEREMQLT 631
Cdd:COG5185   233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTKSID 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  632 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 709
Cdd:COG5185   307 IKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  710 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 789
Cdd:COG5185   387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  790 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 865
Cdd:COG5185   458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 995-1045 8.58e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  995 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20858     6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 998-1046 8.94e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 8.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568936828  998 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1046
Cdd:cd20794     9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1081-1196 9.07e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 9.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828 1081 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1157
Cdd:cd01243    15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568936828 1158 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1196
Cdd:cd01243    91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2-377 9.25e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 9.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    2 EKKLLIKSKELQDSQDKchKMEQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARM 80
Cdd:NF033838  112 EAELTSKTKKELDAAFE--QFKKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   81 EVSQEDdkaLQLLHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRLAAEEFKRKANEC 160
Cdd:NF033838  184 EVKKAE---LELVKEEAKEPRDEEKIKQAK--AKVESKKAEATRLEK-IKTDREKAEEEAKRRADAKLKEAVEKNVATSE 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  161 QHKLMKVVShppRGDSGGTALDDlhKMQGHAgltsakDQGKPEVGEYS------KLEKINAEQQLKIQELQEKLEK---- 230
Cdd:NF033838  258 QDKPKRRAK---RGVLGEPATPD--KKENDA------KSSDSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkee 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  231 ------AVKASTEATELLQNIRQAKErAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDI 304
Cdd:NF033838  327 drrnypTNTYKTLELEIAESDVKVKE-AELELVKEEAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDR 395

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828  305 QTKSEQIQQMADKILELEEKHREAQVSAQHLEVhlkQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 377
Cdd:NF033838  396 KKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP---EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
mukB PRK04863
chromosome partition protein MukB;
482-818 9.95e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.26  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  482 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 561
Cdd:PRK04863  283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  562 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI------VQLRSEVDHLRREITEREMQLTSQKQ 635
Cdd:PRK04863  355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELksqladYQQALDVQQTRAIQYQQAVQALERAK 427

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  636 AQLSAPDLqTMEALKTtctMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--AD 713
Cdd:PRK04863  428 QLCGLPDL-TADNAED---WLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvAR 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  714 QRITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 791
Cdd:PRK04863  500 ELLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVS 575

                         330       340
                  ....*....|....*....|....*..
gi 568936828  792 KLQQQMDLQKNHIFRLTQGLQEALDRA 818
Cdd:PRK04863  576 EARERRMALRQQLEQLQARIQRLAARA 602
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
695-949 1.06e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  695 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 766
Cdd:COG4913   213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  767 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 845
Cdd:COG4913   290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  846 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 925
Cdd:COG4913   358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                         250       260
                  ....*....|....*....|....
gi 568936828  926 EAAHRKATDHPHPSTPATARQQIA 949
Cdd:COG4913   427 EIASLERRKSNIPARLLALRDALA 450
PRK09039 PRK09039
peptidoglycan -binding protein;
619-756 1.18e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 46.11  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  619 LRREITEREMQLtSQKQAQLSapDLQTMEAL-KTTCTMLEEQVLDLEA-LNDELLEKERqWEAWRSVLGDEKSQFECRVR 696
Cdd:PRK09039   44 LSREISGKDSAL-DRLNSQIA--ELADLLSLeRQGNQDLQDSVANLRAsLSAAEAERSR-LQALLAELAGAGAAAEGRAG 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828  697 ELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 756
Cdd:PRK09039  120 ELAQELDSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 240-578 1.21e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   240 ELLQNIRQAKERAERELEKLHnrEDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSEQIQQMADKIL 319
Cdd:pfam07888   30 ELLQNRLEECLQERAELLQAQ--EAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   320 ELEEKHREAQVS----AQHLEVHLKQKEQH------YEEKIKVLD---------------------NQIKKDLADKESLE 368
Cdd:pfam07888   98 ELEEKYKELSASseelSEEKDALLAQRAAHearireLEEDIKTLTqrvleretelermkerakkagAQRKEEEAERKQLQ 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   369 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQA 448
Cdd:pfam07888  178 AKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALLEELRSLQERLNASE 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   449 GKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 522
Cdd:pfam07888  251 RKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAEL 327

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828   523 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 578
Cdd:pfam07888  328 QRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 997-1045 1.22e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  997 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20837     1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 435-921 1.26e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.02  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   435 SELRQQKFYLETQAGKLEAQNRKLEE---QLEKISH------QDHSDKSR-----------LLELETRLREVSLEHEEQK 494
Cdd:pfam05483   99 AELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLkleeeiQENKDLIKennatrhlcnlLKETCARSAEKTKKYEYER 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   495 LELKRQLTELQLSLqerESQLTALQAARAalesQLRQAKTELEETTAEAEEEIQALtahRDEIQRKFDALRNSCTVItdl 574
Cdd:pfam05483  179 EETRQVYMDLNNNI---EKMILAFEELRV----QAENARLEMHFKLKEDHEKIQHL---EEEYKKEINDKEKQVSLL--- 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   575 eeqLNQLTEDNAELNNQNFYLSK------QLDEASGANDE-IVQLRSEVDHLRREITEREMQLTSQKQAQLS-APDLQTm 646
Cdd:pfam05483  246 ---LIQITEKENKMKDLTFLLEEsrdkanQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQRSMSTQKAlEEDLQI- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   647 eALKTTCTMLEEQVLDLEALNDE-------LLEKERQWEAWRSVLGDEKSQFECRVRELqRMLDTEKQSRARADQRITES 719
Cdd:pfam05483  322 -ATKTICQLTEEKEAQMEELNKAkaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   720 RQVVELAVKEHKaEILALQQALKEQKLKAESLSDKLNDLEKKHAML----EMNARSLQQKLETERELKQRLLEEQAKLQQ 795
Cdd:pfam05483  400 KNNKEVELEELK-KILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   796 QMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtklIDFLQAKMDQpakkkkglf 875
Cdd:pfam05483  479 ELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQ----IENLEEKEMN--------- 545

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 568936828   876 sRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 921
Cdd:pfam05483  546 -LRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 225-519 1.27e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.66  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   225 QEKLEKAVKasteatellQNIRQAKERAERELEKlhnredssegiKKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 304
Cdd:pfam17380  290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   305 QTKSEQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHEKGK 383
Cdd:pfam17380  347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   384 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 463
Cdd:pfam17380  406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828   464 KISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam17380  464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 713-870 1.38e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  713 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 788
Cdd:COG1579    16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  789 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 867
Cdd:COG1579    89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                  ...
gi 568936828  868 AKK 870
Cdd:COG1579   169 AAK 171
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 70-761 1.40e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.87  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   70 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 147
Cdd:COG3096   289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  148 LAAEEFKRKANECQHKLMKVVSHPPRGDSG----GTALDDLHK-----MQGHAGLTSAKDQ-GKPE-----VGEYskLEK 212
Cdd:COG3096   368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyQQALDVQQTraiqyQQAVQALEKARALcGLPDltpenAEDY--LAA 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  213 INAEQQL---KIQELQEKLEKAVKASTE---ATELLQNIRQAKERAE---------RELEKLHNREDSSEGIKKKLVEAE 277
Cdd:COG3096   446 FRAKEQQateEVLELEQKLSVADAARRQfekAYELVCKIAGEVERSQawqtarellRRYRSQQALAQRLQQLRAQLAELE 525

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  278 ERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE--------- 348
Cdd:COG3096   526 QRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKElaarapawl 605

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  349 ----KIKVLDNQIKKDLADKESLENMMQ---RHEEEAHEKGKILSEQKAminAMDSKIRSLEQ-------RIVELSE--- 411
Cdd:COG3096   606 aaqdALERLREQSGEALADSQEVTAAMQqllEREREATVERDELAARKQ---ALESQIERLSQpggaedpRLLALAErlg 682

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  412 --------------------------------------ANKLAA-------------NSSLFTQRNMKAQEE-----MIS 435
Cdd:COG3096   683 gvllseiyddvtledapyfsalygparhaivvpdlsavKEQLAGledcpedlyliegDPDSFDDSVFDAEELedavvVKL 762

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  436 ELRQQKFYL------------ETQAGKLEAQNRKLEEQLEKIS------HQDHSDKSRLLEL----------ETRLREVS 487
Cdd:COG3096   763 SDRQWRYSRfpevplfgraarEKRLEELRAERDELAEQYAKASfdvqklQRLHQAFSQFVGGhlavafapdpEAELAALR 842

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  488 leheEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNS 567
Cdd:COG3096   843 ----QRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQA---NLLADETLADRLEELREELDAAQEAQAFIQQH 915

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  568 CTVITDLEEQLNQLTEDNAelnnQNFYLSKQLDEASganDEIVQLRSEVDHLrREITEREMQLTSQKQAQLSAPDLQTME 647
Cdd:COG3096   916 GKALAQLEPLVAVLQSDPE----QFEQLQADYLQAK---EQQRRLKQQIFAL-SEVVQRRPHFSYEDAVGLLGENSDLNE 987

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  648 ALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVREL----QRMLDTEKQSRARADQRITESRQVV 723
Cdd:COG3096   988 KLRARLEQAEEA---RREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLqeleQELEELGVQADAEAEERARIRRDEL 1064

                         810       820       830
                  ....*....|....*....|....*....|....*...
gi 568936828  724 ELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 761
Cdd:COG3096  1065 HEELSQNRSRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 997-1048 1.53e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568936828  997 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd21094     3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 215-519 1.63e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.96  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   215 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 293
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   294 ERRENRLKDDIQTK-SEQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKESLENMMQ 372
Cdd:pfam15905  131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   373 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 452
Cdd:pfam15905  196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828   453 AQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam15905  261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 430-831 1.72e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   430 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEEQKLELKRQLTELQLSLQ 509
Cdd:pfam17380  280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIRQEER 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   510 ERESQltalqaaraalesQLRQakteleettaeaeeeiqaltahrDEIQRKFDALRnsctvitdleeqlnQLTEDNAELN 589
Cdd:pfam17380  359 KRELE-------------RIRQ-----------------------EEIAMEISRMR--------------ELERLQMERQ 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   590 NQNFYLSKQLDEASGandeiVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEalkttctmlEEQVLDLEALNDE 669
Cdd:pfam17380  389 QKNERVRQELEAARK-----VKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLE---------EERAREMERVRLE 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   670 LLEKERQWEAWRsvlgdeksQFECRVRELQRMLDTEKQSRARADQritESRQVVELAVKEHKaeilalqQALKEQKLKAE 749
Cdd:pfam17380  455 EQERQQQVERLR--------QQEEERKRKKLELEKEKRDRKRAEE---QRRKILEKELEERK-------QAMIEEERKRK 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   750 SLSDKLNdlEKKHAMLEMNARslqQKLETERElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 829
Cdd:pfam17380  517 LLEKEME--ERQKAIYEEERR---REAEEERR-KQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590


                   ..
gi 568936828   830 YQ 831
Cdd:pfam17380  591 YE 592
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 605-798 1.93e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  605 ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL 684
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAEL-DALQAELE----ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  685 GDeksqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKL 755
Cdd:COG3883    89 GE-------RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKL 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 568936828  756 NDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 798
Cdd:COG3883   157 AELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 993-1046 2.00e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 2.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  993 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1046
Cdd:cd20828     2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
594-838 2.11e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  594 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEAlndELL 671
Cdd:COG3206   161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfRQKNGLVDLSEEAKLLLQQL-SELESQLAEARA---ELA 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  672 EKERQWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQK 745
Cdd:COG3206   237 EAEARLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEA 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  746 LKAeslsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTER 825
Cdd:COG3206   312 QRI------LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAE 381

                         250
                  ....*....|...
gi 568936828  826 SdleYQLENIQVL 838
Cdd:COG3206   382 A---LTVGNVRVI 391
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
28-626 2.11e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   28 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 106
Cdd:COG4913   285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  107 KE--QEYQAQVEEMRLMMNQLEEDLVSARRRS----DLYESELRESRLAAEEFKRKANECQHKLMKVVSHpprgdsggta 180
Cdd:COG4913   358 ERrrARLEALLAALGLPLPASAEEFAALRAEAaallEALEEELEALEEALAEAEAALRDLRRELRELEAE---------- 427

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  181 LDDLHKMQG--HAGLTSAKDQ-----GKPE-----VGEYsklekinaeqqLKIQELQEKLEKAVKA--STEATELLqnIR 246
Cdd:COG4913   428 IASLERRKSniPARLLALRDAlaealGLDEaelpfVGEL-----------IEVRPEEERWRGAIERvlGGFALTLL--VP 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  247 QAKERAERE-LEKLHNRED-SSEGIKKKLVEAEERR---HSLENKVKRLET---------MERRENRLK-DDIQ------ 305
Cdd:COG4913   495 PEHYAAALRwVNRLHLRGRlVYERVRTGLPDPERPRldpDSLAGKLDFKPHpfrawleaeLGRRFDYVCvDSPEelrrhp 574

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  306 ---TKSEQIQQMAdkilELEEKHREAQVSAQHLevhL----KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 378
Cdd:COG4913   575 raiTRAGQVKGNG----TRHEKDDRRRIRSRYV---LgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERR 647

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  379 HEKGKILSEQKAMINAM--DSKIRSLEQRIVELSEAN-KLAAnsslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN 455
Cdd:COG4913   648 EALQRLAEYSWDEIDVAsaEREIAELEAELERLDASSdDLAA-----LEEQLEELEAELEELEEELDELKGEIGRLEKEL 722

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  456 RKLEEQLEkishqdhsdksrllELETRLREV-SLEHEEQKLELKRQLTELQLSLQERESQlTALQAARAALESQLRQAKt 534
Cdd:COG4913   723 EQAEEELD--------------ELQDRLEAAeDLARLELRALLEERFAAALGDAVERELR-ENLEERIDALRARLNRAE- 786

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  535 eleettaeaeeeiQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIV 610
Cdd:COG4913   787 -------------EELERAMRAFNREWPAETADLDAdlesLPEYLALLDRLEEDGLPEYEERF--KELLNENS--IEFVA 849

                         650
                  ....*....|....*.
gi 568936828  611 QLRSEVDHLRREITER 626
Cdd:COG4913   850 DLLSKLRRAIREIKER 865
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 10-272 2.13e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    10 KELQDSQDKCHKMEQEMTRL-----HRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyitECSSLKRSLEQARMEVSQ 84
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALNDLearlsHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-----NRLTLEKEYLEKEIQELQ 839

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    85 EDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKL 164
Cdd:TIGR02169  840 EQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRL 919

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   165 MKvvshppRGDSGGTALDDLhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQlKIQELQEKLE----KAVKASTEATE 240
Cdd:TIGR02169  920 SE------LKAKLEALEEEL------SEIEDPKGEDEEIPEEELSLEDVQAELQ-RVEEEIRALEpvnmLAIQEYEEVLK 986

                          250       260       270
                   ....*....|....*....|....*....|..
gi 568936828   241 LLQNIRQAKERAERELEKLHNREDSSEGIKKK 272
Cdd:TIGR02169  987 RLDELKEKRAKLEEERKAILERIEEYEKKKRE 1018
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 206-383 2.39e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR----- 280
Cdd:COG4942    35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  281 --------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 346
Cdd:COG4942   115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 568936828  347 EEKIKVLD----------NQIKKDLADKESLENMMQRHEEEAHEKGK 383
Cdd:COG4942   195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 245-398 2.58e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.97  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  245 IRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKIL-ELEE 323
Cdd:PRK00409  504 IEEAKKLIGEDKEKL---NELIASLEELERELEQKAEEAEALLKEAE-------KLKEELEEKKEKLQEEEDKLLeEAEK 573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  324 KHREA-------------QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQK 389
Cdd:PRK00409  574 EAQQAikeakkeadeiikELRQLQKGGYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQK 651


                  ....*....
gi 568936828  390 AMINAMDSK 398
Cdd:PRK00409  652 GEVLSIPDD 660
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 206-533 2.66e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  206 EYSKLEKINAEqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEERRHsLEN 285
Cdd:COG5185   254 KLEKLVEQNTD--LRLEKLGENAESSKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEE 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  286 KVKRLETMerrenrlkddIQTKSEQIQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 365
Cdd:COG5185   330 SKRETETG----------IQNLTAEIEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQ 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  366 SLENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 445
Cdd:COG5185   399 NQRGYAQEILATLEDTLKAADRQ---IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  446 tqagkLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAAL 525
Cdd:COG5185   476 -----VRSKKEDLNEELTQI-------ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILA 540


                  ....*...
gi 568936828  526 ESQLRQAK 533
Cdd:COG5185   541 LENLIPAS 548
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
291-531 2.72e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  291 ETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 370
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  371 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyletqa 448
Cdd:COG3206   242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-------- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  449 gkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAARAALESQ 528
Cdd:COG3206   307 --LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREVEVAREL 366


                  ...
gi 568936828  529 LRQ 531
Cdd:COG3206   367 YES 369
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 214-886 2.90e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.81  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   214 NAEQQLKIQELQEKLEKAVKAsteatelLQNIrqakeraERELEKLH--NREDSSEGIKKKLVEAEERRHSLENKV--KR 289
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDK-------IQNM-------ETATVELHlsNIENKKNELLDIIVEIKKHIHGEINKDlnKI 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   290 LETMERRENRLKDDIQTKS---EQIQQMADKILELEEKHREaQVSAQHL-EVHLKQ---KEQHYEEKIKVLDNQIKKDLA 362
Cdd:TIGR01612  757 LEDFKNKEKELSNKINDYAkekDELNKYKSKISEIKNHYND-QINIDNIkDEDAKQnydKSKEYIKTISIKEDEIFKIIN 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   363 D----KESLENMMQRHEE-EAHEKGKILSEQKA---MINAMDSKIRSLEQRIVElseaNKLAANSSLFTQRNMKAQEEM- 433
Cdd:TIGR01612  836 EmkfmKDDFLNKVDKFINfENNCKEKIDSEHEQfaeLTNKIKAEISDDKLNDYE----KKFNDSKSLINEINKSIEEEYq 911

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   434 -ISELRQQKFYLETQAGKLEA----------QNRKLEEQLEKISHQDHSDKSRLLELETRLrevslehEEQKLELKRQLT 502
Cdd:TIGR01612  912 nINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKNIDTIKESNLIEKSYKDKFDNTL-------IDKINELDKAFK 984

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   503 ELqlSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEiqaltAHRDEIQRKFDALRNSC-------TVITDLE 575
Cdd:TIGR01612  985 DA--SLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEKEK-----ATNDIEQKIEDANKNIPnieiaihTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   576 EQLNQLTEDNAELNNQNFYLS-----------------------------KQLDEASGANDEIVQLRSEVDHLRREITEr 626
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNKEILEEaeinitnfneikeklkhynfddfgkeeniKYADEINKIKDDIKNLDQKIDHHIKALEE- 1136

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   627 emqltSQKQAQlsapdlQTMEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcrvrELQRMLDteK 706
Cdd:TIGR01612 1137 -----IKKKSE------NYIDEIKAQINDLED-VADKAISNDDPEEIEKKIENIVTKIDKKKNIYD----EIKKLLN--E 1198

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   707 QSRARADQRITESRQVVELAVKEHKAEiLALQQaLKEQKLKAE----SLSDKLNDLE--KKHAMLEMNARSLQQKLETER 780
Cdd:TIGR01612 1199 IAEIEKDKTSLEEVKGINLSYGKNLGK-LFLEK-IDEEKKKSEhmikAMEAYIEDLDeiKEKSPEIENEMGIEMDIKAEM 1276

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   781 EL--------KQRLLEEQAKLQQQMDLqKNHIFRLTQGLQEALDRADLLKT----------ERSDLEYQLENIQVLYSHE 842
Cdd:TIGR01612 1277 ETfnishdddKDHHIISKKHDENISDI-REKSLKIIEDFSEESDINDIKKElqknlldaqkHNSDINLYLNEIANIYNIL 1355

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 568936828   843 KV----KMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 886
Cdd:TIGR01612 1356 KLnkikKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLEE 1403
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 995-1045 2.90e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  995 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20843    10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 65-414 3.51e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.81  E-value: 3.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    65 ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSrKLQEIKEQEYQA----QVEEMRLMMNQLEEDLVSARRRSDLYE 140
Cdd:TIGR01612 1364 IDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIESTlddkDIDECIKKIKELKNHILSEESNIDTYF 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   141 SELRESR----LAAEEFKRKANECQHkLMKVvshppRGDSGGTALD-DLHKMQGHagltsaKDQGKPEVGEYSKlekiNA 215
Cdd:TIGR01612 1443 KNADENNenvlLLFKNIEMADNKSQH-ILKI-----KKDNATNDHDfNINELKEH------IDKSKGCKDEADK----NA 1506

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   216 EQQLKIQELQEKLEKAVKA---STEATELLQNIRQAKERAE---RELEKLHNRED-SSEGIKKKLVEAEERRHSLENKVK 288
Cdd:TIGR01612 1507 KAIEKNKELFEQYKKDVTEllnKYSALAIKNKFAKTKKDSEiiiKEIKDAHKKFIlEAEKSEQKIKEIKKEKFRIEDDAA 1586

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   289 RletmERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsaqhlevhLKQKEQhYEEKIKVLD-NQIKKDLADKESL 367
Cdd:TIGR01612 1587 K----NDKSNKAAIDIQLSLENFENKFLKISDIKKKINDC----------LKETES-IEKKISSFSiDSQDTELKENGDN 1651

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936828   368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---------------QRIVELSEANK 414
Cdd:TIGR01612 1652 LNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEidvdqhkknyeigiiEKIKEIAIANK 1713
PRK12704 PRK12704
phosphodiesterase; Provisional
 198-351 4.03e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.15  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  198 DQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHNREDssegikkklvEA 276
Cdd:PRK12704   45 EEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEKREE----------EL 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  277 EERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM----ADKILeLEEKHREAQVSAQHLevhLKQKEQHYEEKIK 351
Cdd:PRK12704  113 EKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLtaeeAKEIL-LEKVEEEARHEAAVL---IKEIEEEAKEEAD 187
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 220-378 4.23e-04

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 43.86  E-value: 4.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERE----------------------------LEKLHNREDSSEGIKK 271
Cdd:pfam00261    2 KMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEvaalnrriqlleeelerteerlaealekLEEAEKAADESERGRK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   272 KL----VEAEERRHSLENKVK-----------RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE 336
Cdd:pfam00261   82 VLenraLKDEEKMEILEAQLKeakeiaeeadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLE 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 568936828   337 VHLK---QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 378
Cdd:pfam00261  162 ASEEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 991-1045 4.27e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  991 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20859    14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 569-797 4.35e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  569 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSApDLQ 644
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEI-EERREELGE-RAR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  645 TMEALKTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVE 724
Cdd:COG3883    94 ALYRSGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELE 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828  725 LAVKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 797
Cdd:COG3883   168 AAKAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 502-832 5.55e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 44.50  E-value: 5.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   502 TELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiqaltahRDEIQRKFDALRNSctvITDLEEQLNQL 581
Cdd:pfam07888   34 NRLEECLQERAELLQAQEAANRQREKEKERYKRD------------------REQWERQRRELESR---VAELKEELRQS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   582 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQV- 660
Cdd:pfam07888   93 REKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAe 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   661 -----LDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEIL 735
Cdd:pfam07888  173 rkqlqAKLQQTEEELRSLSKEFQELRNSLAQRDTQ----VLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   736 ALQQALKEQKLKAESLSDKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHI 804
Cdd:pfam07888  241 SLQERLNASERKVEGLGEELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRI 320

                          330       340
                   ....*....|....*....|....*...
gi 568936828   805 FRLTQGLQEALDRADLLKTERSDLEYQL 832
Cdd:pfam07888  321 EKLSAELQRLEERLQEERMEREKLEVEL 348
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 1008-1045 7.75e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 7.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568936828 1008 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20831    17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
46 PHA02562
endonuclease subunit; Provisional
 703-862 8.33e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 8.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  703 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 773
Cdd:PHA02562  202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  774 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 843
Cdd:PHA02562  282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                         170
                  ....*....|....*....
gi 568936828  844 vkmEGTISQQTKLIDFLQA 862
Cdd:PHA02562  357 ---VDKAKKVKAAIEELQA 372
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 8.48e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883    42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883   122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                         170
                  ....*....|....
gi 568936828  139 YESELRESRLAAEE 152
Cdd:COG3883   201 LEAELAAAEAAAAA 214
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
205-299 8.92e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  205 GEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellqniRQAKERAERELEKLHNREDSsegIKKKLVEAEERRHSLE 284
Cdd:COG2433   427 AEVEELEAELEEKDERIERLERELSEARSE-----------ERREIRKDREISRLDREIER---LERELEEERERIEELK 492

                          90
                  ....*....|....*
gi 568936828  285 NKVKRLETMERRENR 299
Cdd:COG2433   493 RKLERLKELWKLEHS 507
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 223-627 9.24e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.44  E-value: 9.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  223 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLHNREDSSEGIKKK--LVEAEERRHSLE---------NKV---- 287
Cdd:PTZ00440 2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  288 -KRLETMERRENRLKDDIQTKsEQIQQMADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 360
Cdd:PTZ00440 2250 kKKLLDNKNKINNIKDKINDK-EKELINVDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  361 LADKESLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 440
Cdd:PTZ00440 2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  441 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdksrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PTZ00440 2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  521 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 595
Cdd:PTZ00440 2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530

                         410       420       430
                  ....*....|....*....|....*....|..
gi 568936828  596 SKQLDEASGANDEIVQLRSEVDHLRREITERE 627
Cdd:PTZ00440 2531 DNSTYIINELESHVSKLNELLSYIDNEIKELE 2562
PRK12704 PRK12704
phosphodiesterase; Provisional
 300-468 1.04e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  300 LKDDIQTKSEQIQQMADKIleLEEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKeslENMMQRHEEEAH 379
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRI--LEEAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRER---RNELQKLEKRLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  380 EKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftQRNMKAQEEMISELR-QQKFYLETQAG--KLEAQNR 456
Cdd:PRK12704   93 QKEENLDRKLELLEKREEELEKKEKELEQK--------------QQELEKKEEELEELIeEQLQELERISGltAEEAKEI 158

                         170
                  ....*....|..
gi 568936828  457 KLEEQLEKISHQ 468
Cdd:PRK12704  159 LLEKVEEEARHE 170
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
71-359 1.04e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.98  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   71 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 150
Cdd:COG1340    13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  151 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKmqghagltsakdqgkpevgEYSKLEK--------INAEQQL--K 220
Cdd:COG1340    81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRK-------------------EIERLEWrqqtevlsPEEEKELveK 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  221 IQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLenkVKRLETMERRE 297
Cdd:COG1340   142 IKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADELHKEI 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936828  298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKK 359
Cdd:COG1340   219 VEAQEKADELHEEIIELQKELRELRKELKKLR--KKQRALKREKEKEELEEKAEEIFEKLKK 278
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
11-259 1.19e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL--LEQDLATYIT---ECSSLKRSLEQARMEVSQE 85
Cdd:COG4913   625 ELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIaeLEAELERLDAssdDLAALEEQLEELEAELEEL 704

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   86 DDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRS---DLYESELRE---SRLAAEefKRKA 157
Cdd:COG4913   705 EEELDELKGEIGRLEKELEQAEEEldELQDRLEAAEDLARLELRALLEERFAAalgDAVERELREnleERIDAL--RARL 782

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  158 NECQHKLMKVVSH-----PPRGDSGGTALDDLHKMQGHagltsakdqgkpevgeYSKLEKINAEqqlkiqELQEKLEKAV 232
Cdd:COG4913   783 NRAEEELERAMRAfnrewPAETADLDADLESLPEYLAL----------------LDRLEEDGLP------EYEERFKELL 840

                         250       260
                  ....*....|....*....|....*....
gi 568936828  233 KASTEA--TELLQNIRQAKERAERELEKL 259
Cdd:COG4913   841 NENSIEfvADLLSKLRRAIREIKERIDPL 869
46 PHA02562
endonuclease subunit; Provisional
 409-629 1.21e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.46  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  409 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 488
Cdd:PHA02562  165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  489 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK--------------------------TELEETTAE 542
Cdd:PHA02562  231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctqqisegpdriTKIKDKLKE 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  543 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA----NDEIVQLRSEVDH 618
Cdd:PHA02562  311 LQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdnAEELAKLQDELDK 390

                         250
                  ....*....|.
gi 568936828  619 LRREITEREMQ 629
Cdd:PHA02562  391 IVKTKSELVKE 401
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-255 1.23e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828     4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE---QDLATYITECSSLKRSLEQArm 80
Cdd:TIGR02169  778 EEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEkeiQELQEQRIDLKEQIKSIEKE-- 855

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    81 evsQEDDKAlqllhDIREQSRKLQEIKEQEYQ--AQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAN 158
Cdd:TIGR02169  856 ---IENLNG-----KKEELEEELEELEAALRDleSRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLE 927

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   159 ECQHKLMKVVSHPPRGDSGGTALDDLHKMQghagltsAKDQGKPEvgEYSKLEKIN-------AEQQLKIQELQEKLEKA 231
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPEEELSLEDVQ-------AELQRVEE--EIRALEPVNmlaiqeyEEVLKRLDELKEKRAKL 998

                          250       260
                   ....*....|....*....|....
gi 568936828   232 VKASTEATELLQNIRQAKERAERE 255
Cdd:TIGR02169  999 EEERKAILERIEEYEKKKREVFME 1022
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 211-411 1.32e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  211 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLHNREDSS-EGIKKKLVEAEERRHSLENK 286
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  287 VKRLETMERRENRLKD-DIqtkseqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------- 355
Cdd:PRK05771  116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvv 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568936828  356 QIKKDLADKESLenmMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 411
Cdd:PRK05771  185 VLKELSDEVEEE---LKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 269-629 1.36e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 43.30  E-value: 1.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   269 IKKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVH-------L 339
Cdd:pfam06160   65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   340 KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 418
Cdd:pfam06160  138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   419 sslftQRNMKAQ----EEMISELRQQKFYLETQagKLEAQNRKLEEQLEKISHQdhSDKSRLLELETRLREVS------- 487
Cdd:pfam06160  206 -----KTELPDQleelKEGYREMEEEGYALEHL--NVDKEIQQLEEQLEENLAL--LENLELDEAEEALEEIEeridqly 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   488 --LEHE-EQKLELKRQLTELQLSLQERESQLTALQA--ARAALESQLrqakteleetTAEAEEEIQALTAHRDEIQRKFD 562
Cdd:pfam06160  277 dlLEKEvDAKKYVEKNLPEIEDYLEHAEEQNKELKEelERVQQSYTL----------NENELERVRGLEKQLEELEKRYD 346

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568936828   563 ALR----NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgaNDEIVqLRSEVDHLRREITE--REMQ 629
Cdd:pfam06160  347 EIVerleEKEVAYSELQEELEEILEQLEEIEEEQEEFKESLQSLR--KDELE-AREKLDEFKLELREikRLVE 416
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 261-348 1.43e-03

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.79  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   261 NREDSSEGIKKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL----ELEEKHREAQVSAqhL 335
Cdd:pfam00836   39 KKDSSLEEIQKKLEAAEERRKSLEaQKLKQLAEKREKEEEALQKADEENNNFSKMAEEKLkqkmEAYKENREAQIAA--L 116

                           90
                   ....*....|...
gi 568936828   336 EVHLKQKEQHYEE 348
Cdd:pfam00836  117 KEKLKEKEKHVEE 129
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 997-1050 1.43e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  997 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 1050
Cdd:cd20864     3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 997-1048 1.50e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.02  E-value: 1.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568936828  997 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd20809     1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 997-1044 1.77e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568936828  997 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 1044
Cdd:cd20888     6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 992-1045 1.90e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 38.04  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828  992 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20822     3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 206-813 1.94e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 42.82  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAE 277
Cdd:pfam07111   87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSS------LTQAH 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   278 ERrhSLENKVKRLETMERRENRLKddiQTKSEQIQQMAdkileleekhrEAQVSAQHLEVHLKQKEQHYEEKIKVLDNqI 357
Cdd:pfam07111  161 EE--ALSSLTSKAEGLEKSLNSLE---TKRAGEAKQLA-----------EAQKEAELLRKQLSKTQEELEAQVTLVES-L 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   358 KKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISEL 437
Cdd:pfam07111  224 RKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRK 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   438 RQQKFYLETQAGKleaqnrkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslqereSQLTA 517
Cdd:pfam07111  290 IQPSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQ-------EQVTS 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   518 LQAARAALESQLrQAKTELEETTAEAEEEIQAltahrdEIQRKFDALRNSCTVITDLEEQL----NQLTEDNAELNNQNF 593
Cdd:pfam07111  350 QSQEQAILQRAL-QDKAAEVEVERMSAKGLQM------ELSRAQEARRRQQQQTASAEEQLkfvvNAMSSTQIWLETTMT 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   594 YLSKQLDEASGANDEIVQLRSEVdHLRREITEREMQLTSQKQAQ----LSAPDLQTMEALKTTCTMLEEQVLDLE-ALND 668
Cdd:pfam07111  423 RVEQAVARIPSLSNRLSYAVRKV-HTIKGLMARKVALAQLRQEScpppPPAPPVDADLSLELEQLREERNRLDAElQLSA 501

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   669 ELLEKE-----RQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE 743
Cdd:pfam07111  502 HLIQQEvgrarEQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQE 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   744 QKLKAES-----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQ 812
Cdd:pfam07111  582 KVAEVETrlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQ 652


                   .
gi 568936828   813 E 813
Cdd:pfam07111  653 E 653
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 503-871 1.95e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 42.75  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   503 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 578
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   579 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQaqlsa 640
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKK----- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   641 pDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSR 709
Cdd:pfam05622  143 -KLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLE 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   710 A------RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMN 768
Cdd:pfam05622  218 EklealqKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLG 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   769 AR--------SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYS 840
Cdd:pfam05622  298 QEgsyrerltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEA 375

                          410       420       430
                   ....*....|....*....|....*....|.
gi 568936828   841 HEKvkmegtISQQTKLIDFLQAKMDQPAKKK 871
Cdd:pfam05622  376 QSE------LQKKKEQIEELEPKQDSNLAQK 400
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
109-344 2.26e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  109 QEYQAQVEEMRlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANecqhklmkVVSHPPRGDSGGTALDDLHKmq 188
Cdd:COG3206   159 EAYLEQNLELR--REEARKALEFLEEQLPELRKELEEAEAALEEFRQKNG--------LVDLSEEAKLLLQQLSELES-- 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  189 ghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATE--LLQNIRQAKERAERELEKLHNR--ED 264
Cdd:COG3206   227 -----------------QLAEARAELAEAEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARytPN 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  265 SSegikkKLVEAEERRHSLENKVKR------------LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA 332
Cdd:COG3206   290 HP-----DVIALRAQIAALRAQLQQeaqrilasleaeLEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVAR 364

                         250
                  ....*....|..
gi 568936828  333 QHLEVHLKQKEQ 344
Cdd:COG3206   365 ELYESLLQRLEE 376
PRK12704 PRK12704
phosphodiesterase; Provisional
 712-848 2.55e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  712 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 791
Cdd:PRK12704   62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568936828  792 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 848
Cdd:PRK12704  139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 547-666 2.89e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.59  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  547 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 623
Cdd:cd22656   119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568936828  624 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 666
Cdd:cd22656   196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 547-750 3.05e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.74  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  547 IQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEAsgaNDEIVQLRSEVDHLRREITER 626
Cdd:COG3883    25 LSELQAELEAAQAELDALQAE---LEELNEEYNELQAELEALQ-------AEIDKL---QAEIAEAEAEIEERREELGER 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  627 --------------EMQLTSQKQA----------QLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRS 682
Cdd:COG3883    92 aralyrsggsvsylDVLLGSESFSdfldrlsalsKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568936828  683 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 750
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 996-1045 4.57e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 36.88  E-value: 4.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  996 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20796     1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 611-940 4.60e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 4.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   611 QLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQ-TMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsVLGDEKS 689
Cdd:pfam17380  300 RLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQaAIYAEQERMAMERERELERIRQEERKRELER-------IRQEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   690 QFECRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNA 769
Cdd:pfam17380  372 MEISRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEA 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   770 RSLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKV 844
Cdd:pfam17380  433 RQREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEE 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   845 KMEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIEL 920
Cdd:pfam17380  504 RKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMM 578

                          330       340
                   ....*....|....*....|
gi 568936828   921 RSAREEAAHRKATDHPHPST 940
Cdd:pfam17380  579 RQIVESEKARAEYEATTPIT 598
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 996-1048 4.68e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 36.68  E-value: 4.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568936828  996 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 1048
Cdd:cd20887     2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 205-331 5.11e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  205 GEYSKLEKINAEQQLKIQELQEKLEKavkasteATELLQNIRQAKE--RAERELEKLHNREDSSEgikKKLVEAEERRHS 282
Cdd:COG1579    52 TELEDLEKEIKRLELEIEEVEARIKK-------YEEQLGNVRNNKEyeALQKEIESLKRRISDLE---DEILELMERIEE 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568936828  283 LENKVKRLET-MERRENRLKDDIQTKSEQIQQMADKILELEEKhREAQVS 331
Cdd:COG1579   122 LEEELAELEAeLAELEAELEEKKAELDEELAELEAELEELEAE-REELAA 170
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 347-529 5.25e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  347 EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 426
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  427 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEEQKLELKRQLTELQL 506
Cdd:COG1579    88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149

                         170       180
                  ....*....|....*....|...
gi 568936828  507 SLQERESQLTALQAARAALESQL 529
Cdd:COG1579   150 ELAELEAELEELEAEREELAAKI 172
PRK12704 PRK12704
phosphodiesterase; Provisional
 728-855 5.32e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  728 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 804
Cdd:PRK12704   32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568936828  805 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 855
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 10-376 5.35e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 41.38  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   10 KELQDSQDKCHKMEQEMTRLHRRVS--------EVEAVLSQKEVELKASETQRSlleqDLATYITECSSLKRSLEQARME 81
Cdd:PLN03229  376 IAINENMDELGKMDTEELLKHRMLKfrkiggfqEGVPVDPERKVNMKKREAVKT----PVRELEGEVEKLKEQILKAKES 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   82 VSQEDDKALQllhdirEQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELresrlaAEEFKRKANE 159
Cdd:PLN03229  452 SSKPSELALN------EMIEKLKKEIDLEYTEAVIAMGLQerLENLREEFSKANSQDQLMHPVL------MEKIEKLKDE 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  160 CQHKLmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQG---KPEVGEYSKLEKINAEQQLKIQELQEKLEKAvKAST 236
Cdd:PLN03229  520 FNKRL----SRAPNYLSLKYKLDMLNEFSRAKALSEKKSKAeklKAEINKKFKEVMDRPEIKEKMEALKAEVASS-GASS 594

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  237 EAT---ELLQNIRQAKERAERELEKLHNRED-SSEGIKKKLVEAEERR--HSLENKVKRLetmerrenrlKDDIQTKSEQ 310
Cdd:PLN03229  595 GDElddDLKEKVEKMKKEIELELAGVLKSMGlEVIGVTKKNKDTAEQTppPNLQEKIESL----------NEEINKKIER 664

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568936828  311 IQQMADKILELEEKHREAQVSAQHLEVHLKqkeqhyeEKIKVLDNQIKKDLADKESLENMMQRHEE 376
Cdd:PLN03229  665 VIRSSDLKSKIELLKLEVAKASKTPDVTEK-------EKIEALEQQIKQKIAEALNSSELKEKFEE 723
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 220-349 5.37e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 5.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIK----KKLVEA-EERRHSLENKVKRLETME 294
Cdd:smart00787  152 NLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDptelDRAKEKlKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 568936828    295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK 349
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 499-930 5.41e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  499 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 573
Cdd:PRK10929    2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  574 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTSQKQA---QLS 639
Cdd:PRK10929   82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLPQQQTEarrQLN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  640 APDlQTMEALKTTCTMLEE-QVLDLEAlndellekerqweawrsvlgdEKSQFECRVRELQrmldtekQSRARADQRITE 718
Cdd:PRK10929  155 EIE-RRLQTLGTPNTPLAQaQLTALQA---------------------ESAALKALVDELE-------LAQLSANNRQEL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  719 SRQVVELAVKEHkAEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrL 786
Cdd:PRK10929  206 ARLRSELAKKRS-QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-A 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  787 LEEQAklqQQMDL----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEK 843
Cdd:PRK10929  274 LNQQA---QRMDLiasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQR 349

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  844 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTR 917
Cdd:PRK10929  350 LRYEDLLNKQPQLRQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN 424

                         490
                  ....*....|...
gi 568936828  918 ielrsareEAAHR 930
Cdd:PRK10929  425 --------EATHR 429
mukB PRK04863
chromosome partition protein MukB;
373-795 5.93e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  373 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 448
Cdd:PRK04863  276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  449 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQeresqltaLQAARAaleSQ 528
Cdd:PRK04863  355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALD--------VQQTRA---IQ 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  529 LRQAKteleettaeaeeeiQALtahrDEIQR--KFDALrnsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 606
Cdd:PRK04863  416 YQQAV--------------QAL----ERAKQlcGLPDL-----TADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  607 DEIVQ----LRSEVDHLRRE-----ITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVlDLEALNDELLEKERQW 677
Cdd:PRK04863  473 SQFEQayqlVRKIAGEVSRSeawdvARELLRRLREQRHLAEQLQQLRM--RLSELEQRLRQQQ-RAERLLAEFCKRLGKN 549

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  678 EAWRSVLGDEKSQFECRVRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLND 757
Cdd:PRK04863  550 LDDEDELEQLQEELEARLESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALAR 614

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568936828  758 L-EKKHAMLEMNAR---SLQQKLETEREL----------KQRLLEEQAKLQQ 795
Cdd:PRK04863  615 LrEQSGEEFEDSQDvteYMQQLLERERELtverdelaarKQALDEEIERLSQ 666
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 240-340 5.97e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  240 ELLQNIRQAKERAERELEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL 319
Cdd:COG0542   411 EELDELERRLEQLEIEKEAL--KKEQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGKIP 488

                          90       100
                  ....*....|....*....|.
gi 568936828  320 ELEEKHREAQVSAQHLEVHLK 340
Cdd:COG0542   489 ELEKELAELEEELAELAPLLR 509
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 997-1045 6.46e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568936828  997 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1045
Cdd:cd20807     1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
PRK12704 PRK12704
phosphodiesterase; Provisional
 269-456 8.02e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  269 IKKKLVEAEERRhslenkVKRLETMERRENRLKDDIqtKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE 348
Cdd:PRK12704   29 AEAKIKEAEEEA------KRILEEAKKEAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  349 kikvldnqiKKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 428
Cdd:PRK12704  101 ---------KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEE 166

                         170       180
                  ....*....|....*....|....*...
gi 568936828  429 AQEEMISELRQqkfyLETQAgKLEAQNR 456
Cdd:PRK12704  167 ARHEAAVLIKE----IEEEA-KEEADKK 189
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
492-792 8.02e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.28  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  492 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 571
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  572 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI------TEREMQLtsqkqaqlsapdlqt 645
Cdd:COG1340    74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQqtevlsPEEEKEL--------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828  646 MEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvel 725
Cdd:COG1340   139 VEKIKELEKELEK-AKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA----- 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568936828  726 avKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 792
Cdd:COG1340   212 --DELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
Caldesmon pfam02029
Caldesmon;
72-387 9.60e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 40.62  E-value: 9.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828    72 KRSLEQARMEVSQEDDKALQLLHDIREQSRKL----QEIKEQEYQAQVEEMRLM--MNQLEEdlvsaRRRSDLYESELRE 145
Cdd:pfam02029   12 RRRAREERRRQKEEEEPSGQVTESVEPNEHNSyeedSELKPSGQGGLDEEEAFLdrTAKREE-----RRQKRLQEALERQ 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   146 SRL---AAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHA------------GLTSAKDQGKPEVGEYSKL 210
Cdd:pfam02029   87 KEFdptIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIrekeyqenkwstEVRQAEEEGEEEEDKSEEA 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   211 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR----QAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENK 286
Cdd:pfam02029  167 EEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEA 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   287 VKRLETMERRENRLKDDIQTKSEQIQQMAdkILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldnQIKKDlADKES 366
Cdd:pfam02029  247 EQKLEELRRRRQEKESEEFEKLRQKQQEA--ELELEELKKKREERRKLLEEEEQRRKQEEAER------KLREE-EEKRR 317

                          330       340
                   ....*....|....*....|.
gi 568936828   367 LENMMQRHEEEAHEKGKILSE 387
Cdd:pfam02029  318 MKEEIERRRAEAAEKRQKLPE 338
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 423-630 9.64e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.12  E-value: 9.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   423 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 499
Cdd:pfam15619    2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936828   500 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 579
Cdd:pfam15619   82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568936828   580 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 630
Cdd:pfam15619  141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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