|
Name |
Accession |
Description |
Interval |
E-value |
| COG5139 |
COG5139 |
Uncharacterized conserved protein [Function unknown]; |
474-738 |
3.43e-29 |
|
Uncharacterized conserved protein [Function unknown];
Pssm-ID: 227468 Cd Length: 397 Bit Score: 120.57 E-value: 3.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 474 DFEMMLQRKKSMCGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETF 553
Cdd:COG5139 126 ELGDTGDRQLKAPAASRARRKEDLLEQTVDEISLRLKKRMQDAAKKDNANNLEGRPATGKIKNLPEVSDVLMKKALQDTI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 554 IDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPsVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSR 633
Cdd:COG5139 206 LDNNILDSVRGWLEPLPDKSLPNIKIQKSLLDVLKTLP-IHTEHLVESGVGRIVYFYTISKKEEKEVRRSAKALVQEWTR 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 634 PIFGLTSNYKGmTREEREQRDLEQMPQRRRLSSTGGQTpRRDLEKVLTGEEKALRPGDPGFCARARV---PMPSNKDYVV 710
Cdd:COG5139 285 PIIKPSGNYRD-KRIMQLEFDSEKLRKKSVMDSAKNRK-KKSSGEDPTSRGSSVQTLYEQAAARRNRaaaPAQTTTDYKY 362
|
250 260 270
....*....|....*....|....*....|....*
gi 569004601 711 RP-------KWNVEMESSRFQASSKKGISRLDKQM 738
Cdd:COG5139 363 APvsnlsavPTNARAVGVGSTLNNSEMYKRLTSRL 397
|
|
| Med26 |
pfam08711 |
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
582-635 |
3.21e-12 |
|
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.
Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 61.76 E-value: 3.21e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 569004601 582 ELLKILQELPsVSQETLKHSGIGRAVMYLYKHPkESRSNKDMAGKLINEWSRPI 635
Cdd:pfam08711 1 KLLKKLEKLP-VTLELLKSTGIGKVVNKLRKHK-ENPEIKKLAKELVKKWKRLV 52
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
66-417 |
4.44e-12 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 69.94 E-value: 4.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 66 GTDSENDEPSNANASDSESEElhrPKDSDSDSEEHAESpASDSENEPVNQHGSDSENeellnghASDSEKEEVSKHAASD 145
Cdd:NF033609 566 GSDSGSDSSNSDSGSDSGSDS---TSDSGSDSASDSDS-ASDSDSASDSDSASDSDS-------ASDSDSASDSDSASDS 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 146 SEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSE 225
Cdd:NF033609 635 DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSD 707
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 226 SE-DPPRPQASDSESEelpkprvSDSESE-DPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKG 303
Cdd:NF033609 708 SDsDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 304 LHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVAS 383
Cdd:NF033609 781 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 860
|
330 340 350
....*....|....*....|....*....|....
gi 569004601 384 DSEEEAGKEESSVKKKEDKDlfGSDSESGNEEEN 417
Cdd:NF033609 861 NSDSESGSNNNVVPPNSPKN--GTNASNKNEAKD 892
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
3-312 |
6.23e-11 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 66.09 E-value: 6.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSV-DHHSENETSDREDGLAKIHNGTDSENDEPSNANASD 81
Cdd:NF033609 571 SDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSAsDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDS 650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESpASDSENEPVNQHGSDSENEellnghaSDSEKEEVSKHAASDSEAEDTLQPQVSESDS 161
Cdd:NF033609 651 DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 eDPPRPQASDSENEeppkpriSDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESE-DPPRPQASDSESE 240
Cdd:NF033609 723 -DSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSD 787
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569004601 241 ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEE 312
Cdd:NF033609 788 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESD 859
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
58-413 |
7.46e-11 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 65.70 E-value: 7.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 58 DGLAKIHNGTDSEN--DEPSNANASDSESEELHRPKDSDSD--SEEHAESPASDSENEPVNQHGSDSENEEllnghASDS 133
Cdd:NF033609 524 DNEVAFNNGSGSGDgiDKPVVPEQPDEPGEIEPIPEDSDSDpgSDSGSDSSNSDSGSDSGSDSTSDSGSDS-----ASDS 598
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 134 EKEEVSKHAASDSEAEDTlqPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSES 213
Cdd:NF033609 599 DSASDSDSASDSDSASDS--DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 214 EELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESeDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQN 293
Cdd:NF033609 677 DSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 748
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 294 ESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDK 373
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 828
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 569004601 374 SGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGN 413
Cdd:NF033609 829 DSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGS 868
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
2-312 |
1.10e-08 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 58.77 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSENDEPSNANASD 81
Cdd:NF033609 601 ASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESpASDSENEPVNQHGSDSENEEllnghASDSEKEEVSKHAASDSEAEDTLQPQVSESDS 161
Cdd:NF033609 681 DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 754
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESE-DPPRPQASDSESE 240
Cdd:NF033609 755 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSD 827
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569004601 241 ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGEN------KREDSEVQNESDGHTDRKGLHSSDSEEE 312
Cdd:NF033609 828 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNvvppnsPKNGTNASNKNEAKDSKEPLPDTGSEDE 905
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
96-463 |
3.84e-07 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 53.76 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 96 DSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENE 175
Cdd:NF033609 549 DEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 176 EPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESEdpprpqaSDSESEELPKPRVSDSESEDP 255
Cdd:NF033609 629 DSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSD-------SDSDSDSDSDSDSDSDSDSDS 694
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 256 QKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEepkrqkidsdddeekegdeekva 335
Cdd:NF033609 695 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD----------------------- 751
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 336 krkaavlSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEE 415
Cdd:NF033609 752 -------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 824
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 569004601 416 ENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNI 463
Cdd:NF033609 825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNV 872
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
154-474 |
5.69e-07 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 53.37 E-value: 5.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 154 PQVSESDSEDPPRPQASDSEneePPKPRISDSESEELPKPRVSDSESeDPPRPQASDSESEElPKPRVSDSESeDPPRPQ 233
Cdd:NF033609 545 PEQPDEPGEIEPIPEDSDSD---PGSDSGSDSSNSDSGSDSGSDSTS-DSGSDSASDSDSAS-DSDSASDSDS-ASDSDS 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 234 ASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEE 313
Cdd:NF033609 619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 314 PKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEE 393
Cdd:NF033609 699 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 394 SSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLS 473
Cdd:NF033609 779 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSES 858
|
.
gi 569004601 474 D 474
Cdd:NF033609 859 D 859
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
72-317 |
1.05e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.48 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 72 DEPSNANASDSESEElhrPKDSDSDSEEHAESPASD-SENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAED 150
Cdd:PHA03307 101 AREGSPTPPGPSSPD---PPPPTPPPASPPPSPAPDlSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 151 TLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDP- 229
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPl 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 230 PRP----------QASDSESEELPKPRVSdSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENkREDSEVQNESDGHT 299
Cdd:PHA03307 258 PRPapitlptriwEASGWNGPSSRPGPAS-SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS-RESSSSSTSSSSES 335
|
250
....*....|....*....
gi 569004601 300 DRK-GLHSSDSEEEEPKRQ 317
Cdd:PHA03307 336 SRGaAVSPGPSPSRSPSPS 354
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
11-260 |
2.27e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.31 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 11 SDDGGATPV-QDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTD---SENDEPSNANASDSESEE 86
Cdd:pfam03154 27 SPDGRASPTnEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREkgaSDTEEPERATAKKSKTQE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 87 LHRPkdsDSDSEEHAESpasdSENEPVNQHG-SDSENEELLNGHASDSEKEEVSKHAASDSEAEDT-LQPQVSESDSEDP 164
Cdd:pfam03154 107 ISRP---NSPSEGEGES----SDGRSVNDEGsSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQiLQTQPPVLQAQSG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 165 PRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSeseelPKPRVSDSESEDPPRPQASDSESEELPK 244
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-----PHTLIQQTPTLHPQRLPSPHPPLQPMTQ 254
|
250
....*....|....*.
gi 569004601 245 PRVSDSESEDPQKGPA 260
Cdd:pfam03154 255 PPPPSQVSPQPLPQPS 270
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
201-474 |
4.96e-06 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 50.29 E-value: 4.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 201 EDPPRPQASDSESEELPKPRVSDSeseDPPRPQASDSESEELPKPRVSDSESE---DPQKGPASDSEAEDASRHKEKPDS 277
Cdd:NF033609 540 DKPVVPEQPDEPGEIEPIPEDSDS---DPGSDSGSDSSNSDSGSDSGSDSTSDsgsDSASDSDSASDSDSASDSDSASDS 616
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 278 DDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSR 357
Cdd:NF033609 617 DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 358 VVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGF 437
Cdd:NF033609 697 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 776
|
250 260 270
....*....|....*....|....*....|....*..
gi 569004601 438 NQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSD 474
Cdd:NF033609 777 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 813
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
162-474 |
1.01e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 49.14 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEelpkprvSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRPQASDSESEE 241
Cdd:NF033609 540 DKPVVPEQPDEPGEIEPIPEDSDSDPG-------SDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDS 612
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 242 lpkprVSDSES-EDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKID 320
Cdd:NF033609 613 -----ASDSDSaSDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 321 SDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKE 400
Cdd:NF033609 688 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569004601 401 DKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSD 474
Cdd:NF033609 768 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
205-461 |
1.08e-04 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 45.76 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 205 RPQASDSESEELPKPRVSDSESEDPPRPQASDSESE-ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGE 283
Cdd:TIGR00927 619 RPVAKVMALGDLSKGDVAEAEHTGERTGEEGERPTEaEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGE 698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 284 NKREDSEVQNESD-GHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSD---SEDDAGNASKKSRVV 359
Cdd:TIGR00927 699 IEAKEADHKGETEaEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDrkeTEHEGETEAEGKEDE 778
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 360 CDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEE-----EEF 434
Cdd:TIGR00927 779 DEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKgvdggGGS 858
|
250 260
....*....|....*....|....*..
gi 569004601 435 TGFNQEDLEEEKNETQLKEAEDSDSDD 461
Cdd:TIGR00927 859 DGGDSEEEEEEEEEEEEEEEEEEEEEE 885
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
50-462 |
1.95e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 41.92 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 50 ENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGH 129
Cdd:COG5271 580 ENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAE 659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 130 AS-DSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPriSDSESEELPKPRVSDSESEDPPRPQA 208
Cdd:COG5271 660 ASaDESEEEAEDESETSSEDAEEDADAAAAEASDDEEETEEADEDAETASEE--ADAEEADTEADGTAEEAEEAAEEAES 737
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 209 SDSESEELPKPRVSDSESEDPPRPQASD-----SESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGE 283
Cdd:COG5271 738 ADEEAASLPDEADAEEEAEEAEEAEEDDadgleEALEEEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEA 817
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 284 NKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDeekvAKRKAAVLSDSEDDAGNASKKSRVVCDAD 363
Cdd:COG5271 818 DEEEDLDGEDEETADEALEDIEAGIAEDDEEDDDAAAAKDVDADLDL----DADLAADEHEAEEAQEAETDADADADAGE 893
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 364 DSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE 443
Cdd:COG5271 894 ADSSGESSAAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEESDDAAADDAGDDSL 973
|
410
....*....|....*....
gi 569004601 444 EEKNETQLKEAEDSDSDDN 462
Cdd:COG5271 974 ADDDEALADAADDAEADDS 992
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
152-280 |
6.08e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 40.14 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 152 LQPQVSESDSEDPPRPQASDSE-NEEPPKPRISDSESEELPKPRVsdseSEDPPRPQASDSESEELPKPRVSDSesedPP 230
Cdd:NF033839 365 VKPQPEKPKPEVKPQPETPKPEvKPQPEKPKPEVKPQPEKPKPEV----KPQPEKPKPEVKPQPEKPKPEVKPQ----PE 436
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 569004601 231 RPQASDSESEELPKPRV-SDSESEDPQKGPASDSEAEDASRHKEKPDSDDS 280
Cdd:NF033839 437 KPKPEVKPQPEKPKPEVkPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNS 487
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5139 |
COG5139 |
Uncharacterized conserved protein [Function unknown]; |
474-738 |
3.43e-29 |
|
Uncharacterized conserved protein [Function unknown];
Pssm-ID: 227468 Cd Length: 397 Bit Score: 120.57 E-value: 3.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 474 DFEMMLQRKKSMCGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETF 553
Cdd:COG5139 126 ELGDTGDRQLKAPAASRARRKEDLLEQTVDEISLRLKKRMQDAAKKDNANNLEGRPATGKIKNLPEVSDVLMKKALQDTI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 554 IDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPsVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSR 633
Cdd:COG5139 206 LDNNILDSVRGWLEPLPDKSLPNIKIQKSLLDVLKTLP-IHTEHLVESGVGRIVYFYTISKKEEKEVRRSAKALVQEWTR 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 634 PIFGLTSNYKGmTREEREQRDLEQMPQRRRLSSTGGQTpRRDLEKVLTGEEKALRPGDPGFCARARV---PMPSNKDYVV 710
Cdd:COG5139 285 PIIKPSGNYRD-KRIMQLEFDSEKLRKKSVMDSAKNRK-KKSSGEDPTSRGSSVQTLYEQAAARRNRaaaPAQTTTDYKY 362
|
250 260 270
....*....|....*....|....*....|....*
gi 569004601 711 RP-------KWNVEMESSRFQASSKKGISRLDKQM 738
Cdd:COG5139 363 APvsnlsavPTNARAVGVGSTLNNSEMYKRLTSRL 397
|
|
| Med26 |
pfam08711 |
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
582-635 |
3.21e-12 |
|
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.
Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 61.76 E-value: 3.21e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 569004601 582 ELLKILQELPsVSQETLKHSGIGRAVMYLYKHPkESRSNKDMAGKLINEWSRPI 635
Cdd:pfam08711 1 KLLKKLEKLP-VTLELLKSTGIGKVVNKLRKHK-ENPEIKKLAKELVKKWKRLV 52
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
66-417 |
4.44e-12 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 69.94 E-value: 4.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 66 GTDSENDEPSNANASDSESEElhrPKDSDSDSEEHAESpASDSENEPVNQHGSDSENeellnghASDSEKEEVSKHAASD 145
Cdd:NF033609 566 GSDSGSDSSNSDSGSDSGSDS---TSDSGSDSASDSDS-ASDSDSASDSDSASDSDS-------ASDSDSASDSDSASDS 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 146 SEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSE 225
Cdd:NF033609 635 DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSD 707
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 226 SE-DPPRPQASDSESEelpkprvSDSESE-DPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKG 303
Cdd:NF033609 708 SDsDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 304 LHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVAS 383
Cdd:NF033609 781 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 860
|
330 340 350
....*....|....*....|....*....|....
gi 569004601 384 DSEEEAGKEESSVKKKEDKDlfGSDSESGNEEEN 417
Cdd:NF033609 861 NSDSESGSNNNVVPPNSPKN--GTNASNKNEAKD 892
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
3-312 |
6.23e-11 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 66.09 E-value: 6.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSV-DHHSENETSDREDGLAKIHNGTDSENDEPSNANASD 81
Cdd:NF033609 571 SDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSAsDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDS 650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESpASDSENEPVNQHGSDSENEellnghaSDSEKEEVSKHAASDSEAEDTLQPQVSESDS 161
Cdd:NF033609 651 DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 eDPPRPQASDSENEeppkpriSDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESE-DPPRPQASDSESE 240
Cdd:NF033609 723 -DSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSD 787
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569004601 241 ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEE 312
Cdd:NF033609 788 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESD 859
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
58-413 |
7.46e-11 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 65.70 E-value: 7.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 58 DGLAKIHNGTDSEN--DEPSNANASDSESEELHRPKDSDSD--SEEHAESPASDSENEPVNQHGSDSENEEllnghASDS 133
Cdd:NF033609 524 DNEVAFNNGSGSGDgiDKPVVPEQPDEPGEIEPIPEDSDSDpgSDSGSDSSNSDSGSDSGSDSTSDSGSDS-----ASDS 598
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 134 EKEEVSKHAASDSEAEDTlqPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSES 213
Cdd:NF033609 599 DSASDSDSASDSDSASDS--DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 676
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 214 EELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESeDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQN 293
Cdd:NF033609 677 DSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 748
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 294 ESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDK 373
Cdd:NF033609 749 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 828
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 569004601 374 SGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGN 413
Cdd:NF033609 829 DSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGS 868
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
2-312 |
1.10e-08 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 58.77 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSENDEPSNANASD 81
Cdd:NF033609 601 ASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESpASDSENEPVNQHGSDSENEEllnghASDSEKEEVSKHAASDSEAEDTLQPQVSESDS 161
Cdd:NF033609 681 DSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 754
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESE-DPPRPQASDSESE 240
Cdd:NF033609 755 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDsDSDSDSDSDSDSD 827
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569004601 241 ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGEN------KREDSEVQNESDGHTDRKGLHSSDSEEE 312
Cdd:NF033609 828 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNvvppnsPKNGTNASNKNEAKDSKEPLPDTGSEDE 905
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
96-463 |
3.84e-07 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 53.76 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 96 DSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENE 175
Cdd:NF033609 549 DEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 628
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 176 EPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEelpkprvSDSESEdpprpqaSDSESEELPKPRVSDSESEDP 255
Cdd:NF033609 629 DSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSD-------SDSDSDSDSDSDSDSDSDSDS 694
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 256 QKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEepkrqkidsdddeekegdeekva 335
Cdd:NF033609 695 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD----------------------- 751
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 336 krkaavlSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEE 415
Cdd:NF033609 752 -------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 824
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 569004601 416 ENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNI 463
Cdd:NF033609 825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNV 872
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
154-474 |
5.69e-07 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 53.37 E-value: 5.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 154 PQVSESDSEDPPRPQASDSEneePPKPRISDSESEELPKPRVSDSESeDPPRPQASDSESEElPKPRVSDSESeDPPRPQ 233
Cdd:NF033609 545 PEQPDEPGEIEPIPEDSDSD---PGSDSGSDSSNSDSGSDSGSDSTS-DSGSDSASDSDSAS-DSDSASDSDS-ASDSDS 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 234 ASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEE 313
Cdd:NF033609 619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 314 PKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEE 393
Cdd:NF033609 699 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 394 SSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLS 473
Cdd:NF033609 779 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSES 858
|
.
gi 569004601 474 D 474
Cdd:NF033609 859 D 859
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
72-317 |
1.05e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.48 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 72 DEPSNANASDSESEElhrPKDSDSDSEEHAESPASD-SENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAED 150
Cdd:PHA03307 101 AREGSPTPPGPSSPD---PPPPTPPPASPPPSPAPDlSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 151 TLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDP- 229
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPl 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 230 PRP----------QASDSESEELPKPRVSdSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENkREDSEVQNESDGHT 299
Cdd:PHA03307 258 PRPapitlptriwEASGWNGPSSRPGPAS-SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS-RESSSSSTSSSSES 335
|
250
....*....|....*....
gi 569004601 300 DRK-GLHSSDSEEEEPKRQ 317
Cdd:PHA03307 336 SRGaAVSPGPSPSRSPSPS 354
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
64-270 |
1.84e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.71 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 64 HNGTDSENDEPSNANASDSESEelhRPKDSDSDseehAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAA 143
Cdd:PHA03307 202 ASPRPPRRSSPISASASSPAPA---PGRSAADD----AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASG 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 144 SDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPR-----ISDSESEELPKPRvSDSESEDPPRPQASDSESeELPK 218
Cdd:PHA03307 275 WNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPrasssSSSSRESSSSSTS-SSSESSRGAAVSPGPSPS-RSPS 352
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 569004601 219 PRvSDSESEDPPRPQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASR 270
Cdd:PHA03307 353 PS-RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDA 403
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
11-260 |
2.27e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.31 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 11 SDDGGATPV-QDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTD---SENDEPSNANASDSESEE 86
Cdd:pfam03154 27 SPDGRASPTnEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREkgaSDTEEPERATAKKSKTQE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 87 LHRPkdsDSDSEEHAESpasdSENEPVNQHG-SDSENEELLNGHASDSEKEEVSKHAASDSEAEDT-LQPQVSESDSEDP 164
Cdd:pfam03154 107 ISRP---NSPSEGEGES----SDGRSVNDEGsSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQiLQTQPPVLQAQSG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 165 PRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSeseelPKPRVSDSESEDPPRPQASDSESEELPK 244
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-----PHTLIQQTPTLHPQRLPSPHPPLQPMTQ 254
|
250
....*....|....*.
gi 569004601 245 PRVSDSESEDPQKGPA 260
Cdd:pfam03154 255 PPPPSQVSPQPLPQPS 270
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
64-287 |
2.75e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.94 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 64 HNGTDSENDEPSNANASDSESEELHRPKDSD--SDSEEHAESPASDSENEPVNQHGSDSEneellnghASDSEKEEVSKH 141
Cdd:PHA03307 144 PGPPPAASPPAAGASPAAVASDAASSRQAALplSSPEETARAPSSPPAEPPPSTPPAAAS--------PRPPRRSSPISA 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 142 AASDSEA----EDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELP-KPRVSDSESEDPPRPQASDSESEEL 216
Cdd:PHA03307 216 SASSPAPapgrSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIwEASGWNGPSSRPGPASSSSSPRERS 295
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569004601 217 PKP-RVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKRE 287
Cdd:PHA03307 296 PSPsPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRK 367
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
201-474 |
4.96e-06 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 50.29 E-value: 4.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 201 EDPPRPQASDSESEELPKPRVSDSeseDPPRPQASDSESEELPKPRVSDSESE---DPQKGPASDSEAEDASRHKEKPDS 277
Cdd:NF033609 540 DKPVVPEQPDEPGEIEPIPEDSDS---DPGSDSGSDSSNSDSGSDSGSDSTSDsgsDSASDSDSASDSDSASDSDSASDS 616
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 278 DDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSR 357
Cdd:NF033609 617 DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 358 VVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGF 437
Cdd:NF033609 697 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 776
|
250 260 270
....*....|....*....|....*....|....*..
gi 569004601 438 NQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSD 474
Cdd:NF033609 777 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 813
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
90-297 |
5.32e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 50.07 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 90 PKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQP-QVSESDSEDPPRPQ 168
Cdd:PTZ00449 497 APIEEEDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPgPAKEHKPSKIPTLS 576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 169 ASDSENEEPPKPRisDSESEELPKPRVSDSESEDPP---RPQASD-------SESEELPKPRVSDSESEDPPRPQAsdSE 238
Cdd:PTZ00449 577 KKPEFPKDPKHPK--DPEEPKKPKRPRSAQRPTRPKspkLPELLDipkspkrPESPKSPKRPPPPQRPSSPERPEG--PK 652
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 239 SEELPKPRVSDSESEDPQ-KGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDG 297
Cdd:PTZ00449 653 IIKSPKPPKSPKPPFDPKfKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPG 712
|
|
| PHA03321 |
PHA03321 |
tegument protein VP11/12; Provisional |
161-319 |
8.24e-06 |
|
tegument protein VP11/12; Provisional
Pssm-ID: 223041 [Multi-domain] Cd Length: 694 Bit Score: 49.19 E-value: 8.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 161 SEDPPRPQASDSENEEPPKPRISDSESEElpKPRVSDSESEDPPRPQASDSESE--ELPKPRVSDSESEDPPRPQA---S 235
Cdd:PHA03321 427 SRQPPGAPAPRRDNDPPPPPRARPGSTPA--CARRARAQRARDAGPEYVDPLGAlrRLPAGAAPPPEPAAAPSPATyytR 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 236 DSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESD-GHTDRKGLHSSDSEEEEP 314
Cdd:PHA03321 505 MGGGPPRLPPRNRATETLRPDWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREaPAPDDDPIYEGVSDSEEP 584
|
....*
gi 569004601 315 KRQKI 319
Cdd:PHA03321 585 VYEEI 589
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
162-474 |
1.01e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 49.14 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEelpkprvSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRPQASDSESEE 241
Cdd:NF033609 540 DKPVVPEQPDEPGEIEPIPEDSDSDPG-------SDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDS 612
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 242 lpkprVSDSES-EDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKID 320
Cdd:NF033609 613 -----ASDSDSaSDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 321 SDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKE 400
Cdd:NF033609 688 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569004601 401 DKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSD 474
Cdd:NF033609 768 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
48-281 |
1.04e-05 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 49.27 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 48 HSENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENepvNQHGSDSENEELLN 127
Cdd:PTZ00108 1157 RLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSN---SSGSDQEDDEEQKT 1233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 128 GHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPR--PQASDSENEEPPKP-RISDSESEELPKPRVSDSESEDPP 204
Cdd:PTZ00108 1234 KPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKnaPKRVSAVQYSPPPPsKRPDGESNGGSKPSSPTKKKVKKR 1313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 205 -RPQASDSESEELPKPRVSDSESEDPPRPQASDSESEEL---PKPRVSDSESEDpqkgpaSDSEAEDASRHKEKPDSDDS 280
Cdd:PTZ00108 1314 lEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLlrrPRKKKSDSSSED------DDDSEVDDSEDEDDEDDEDD 1387
|
.
gi 569004601 281 D 281
Cdd:PTZ00108 1388 D 1388
|
|
| PRK08581 |
PRK08581 |
amidase domain-containing protein; |
57-302 |
1.85e-05 |
|
amidase domain-containing protein;
Pssm-ID: 236304 [Multi-domain] Cd Length: 619 Bit Score: 48.25 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 57 EDGLAKIHNGTDSENDEPSNANaSDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKE 136
Cdd:PRK08581 28 DDPQKDSTAKTTSHDSKKSNDD-ETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNIIDFIYKNLPQTNINQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 137 EVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEElpkprVSDSESEDPPRPQASDSESEEL 216
Cdd:PRK08581 107 LLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKN-----DTDTQSSKQDKADNQKAPSSNN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 217 PKPRVSDSESEDPPRPQASDSESEelpkprvSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESD 296
Cdd:PRK08581 182 TKPSTSNKQPNSPKPTQPNQSNSQ-------PASDDTANQKSSSKDNQSMSDSALDSILDQYSEDAKKTQKDYASQSKKD 254
|
....*.
gi 569004601 297 GHTDRK 302
Cdd:PRK08581 255 KTETSN 260
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
74-297 |
1.03e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 45.35 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 74 PSNANASDSESEELHRpkdSDSDSEEHAESPASDSENEPVNQHGSDSENEEllnGHASDSEKEEVSKHAASDSEAEDTLQ 153
Cdd:PHA03169 42 RAAKPAPPAPTTSGPQ---VRAVAEQGHRQTESDTETAEESRHGEKEERGQ---GGPSGSGSESVGSPTPSPSGSAEELA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 154 PQVSESDSEDppRPQASDSENEEPPKPRISDSESEElpkprvSDSESEDPPRPQASDSESEElpkprvSDSESEDPPRPQ 233
Cdd:PHA03169 116 SGLSPENTSG--SSPESPASHSPPPSPPSHPGPHEP------APPESHNPSPNQQPSSFLQP------SHEDSPEEPEPP 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569004601 234 ASDSEsEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDG 297
Cdd:PHA03169 182 TSEPE-PDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREG 244
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
84-294 |
1.04e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.93 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 84 SEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPqvsESDSED 163
Cdd:PHA03307 39 SQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP---GPSSPD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 164 PPRPQASDSENEEPPKPRIS---DSESEELPKPRVSDSESEDPPRPQASDSESE---ELPKPRVSDSE-------SEDPP 230
Cdd:PHA03307 116 PPPPTPPPASPPPSPAPDLSemlRPVGSPGPPPAASPPAAGASPAAVASDAASSrqaALPLSSPEETArapssppAEPPP 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569004601 231 RPQASDSEseelPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDgENKREDSEVQNE 294
Cdd:PHA03307 196 STPPAAAS----PRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSS-ESSGCGWGPENE 254
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
205-461 |
1.08e-04 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 45.76 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 205 RPQASDSESEELPKPRVSDSESEDPPRPQASDSESE-ELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGE 283
Cdd:TIGR00927 619 RPVAKVMALGDLSKGDVAEAEHTGERTGEEGERPTEaEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGE 698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 284 NKREDSEVQNESD-GHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSD---SEDDAGNASKKSRVV 359
Cdd:TIGR00927 699 IEAKEADHKGETEaEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDrkeTEHEGETEAEGKEDE 778
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 360 CDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEE-----EEF 434
Cdd:TIGR00927 779 DEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKgvdggGGS 858
|
250 260
....*....|....*....|....*..
gi 569004601 435 TGFNQEDLEEEKNETQLKEAEDSDSDD 461
Cdd:TIGR00927 859 DGGDSEEEEEEEEEEEEEEEEEEEEEE 885
|
|
| ECM1 |
pfam05782 |
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ... |
164-275 |
2.09e-04 |
|
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.
Pssm-ID: 461739 Cd Length: 518 Bit Score: 44.45 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 164 PPRPqasdsenEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRPQASDSESEELP 243
Cdd:pfam05782 6 PPSP-------PQTRGLPVDHPDTSQHDPPFEGQSEVQPPPSQEAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELP 78
|
90 100 110
....*....|....*....|....*....|...
gi 569004601 244 KPRVSDSESE-DPQKGPasDSEAEDASRHKEKP 275
Cdd:pfam05782 79 PPQLPIEQKEiDPPFPQ--QEEITPSKQREEKP 109
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
66-235 |
3.44e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.31 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 66 GTDSENDEPSNANASDSESE-ELHRPKDSDSDSEEHAESPA-------SDSENEPVNQHGSDSENEELLNGhasdsekee 137
Cdd:PRK10263 677 GEQYQHDVPVNAEDADAAAEaELARQFAQTQQQRYSGEQPAganpfslDDFEFSPMKALLDDGPHEPLFTP--------- 747
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 138 vSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELP 217
Cdd:PRK10263 748 -IVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAP 826
|
170
....*....|....*...
gi 569004601 218 KPRVSDSESEDPPRPQAS 235
Cdd:PRK10263 827 QPQYQQPQQPVAPQPQDT 844
|
|
| PRK08581 |
PRK08581 |
amidase domain-containing protein; |
2-203 |
7.77e-04 |
|
amidase domain-containing protein;
Pssm-ID: 236304 [Multi-domain] Cd Length: 619 Bit Score: 42.85 E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSEND-EPSNANAS 80
Cdd:PRK08581 104 INQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQSSKQDKADNQkAPSSNNTK 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 81 DSESEELHRPK------DSDSDSEEHAESPASDSENEpvNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQ- 153
Cdd:PRK08581 184 PSTSNKQPNSPkptqpnQSNSQPASDDTANQKSSSKD--NQSMSDSALDSILDQYSEDAKKTQKDYASQSKKDKTETSNt 261
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 569004601 154 --PQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKprVSDSESEDP 203
Cdd:PRK08581 262 knPQLPTQDELKHKSKPAQSFENDVNQSNTRSTSLFETGPS--LSNNDDSGS 311
|
|
| PRK13108 |
PRK13108 |
prolipoprotein diacylglyceryl transferase; Reviewed |
93-236 |
8.31e-04 |
|
prolipoprotein diacylglyceryl transferase; Reviewed
Pssm-ID: 237284 [Multi-domain] Cd Length: 460 Bit Score: 42.66 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 93 SDSDSEEHAESPASDSEnepvnQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTlQPQVSESDSEDPPRPQASDS 172
Cdd:PRK13108 306 AAVASAASAVGPVGPGE-----PNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGES-TPAVEETSEADIEREQPGDL 379
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569004601 173 ENEEPPKPRISDSESEELP-KPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDP-PRPQASD 236
Cdd:PRK13108 380 AGQAPAAHQVDAEAASAAPeEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPgDDPAEPD 445
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
135-461 |
9.83e-04 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 9.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 135 KEEVSKHAASDSEAEDTLqpqvSESDSEDPPRPQASDSENEEPPKprisdseSEELPKPRVSDSESEDPPRPQA-SDSES 213
Cdd:TIGR00927 613 KEQLSRRPVAKVMALGDL----SKGDVAEAEHTGERTGEEGERPT-------EAEGENGEESGGEAEQEGETETkGENES 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 214 E-ELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDpqKGPASDSEAEDASRHKEKPDSDDSDGENKrEDSEVQ 292
Cdd:TIGR00927 682 EgEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEA--EGTEDEGEIETGEEGEEVEDEGEGEAEGK-HEVETE 758
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 293 NESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASkksrvvcdadDSDSDVVSD 372
Cdd:TIGR00927 759 GDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQS----------ETQADDTEV 828
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 373 KSGKRETTVASDSEEEAGKEESSVKKKEDKDlfGSDSESGNEEEnliadifgesgdeeeeeftgfnqEDLEEEKNETQLK 452
Cdd:TIGR00927 829 KDETGEQELNAENQGEAKQDEKGVDGGGGSD--GGDSEEEEEEE-----------------------EEEEEEEEEEEEE 883
|
....*....
gi 569004601 453 EAEDSDSDD 461
Cdd:TIGR00927 884 EEEEEENEE 892
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
128-314 |
1.05e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 128 GHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDP-PRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRP 206
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAaPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 207 QASD------SESEELPKPRVSDSESEDPPRPQASDSESEElPKPRVSDSESEDPQK----GPASDSEAEDASRHKEKPD 276
Cdd:PRK07764 669 WPAKaggaapAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP-PAGQADDPAAQPPQAaqgaSAPSPAADDPVPLPPEPDD 747
|
170 180 190
....*....|....*....|....*....|....*...
gi 569004601 277 SDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEP 314
Cdd:PRK07764 748 PPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
153-261 |
1.50e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 153 QPQVSEsdsedPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRP 232
Cdd:PHA03247 2888 RPAVSR-----STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
90 100
....*....|....*....|....*....
gi 569004601 233 QASDSESEELPKPRVSDSESEDPQKGPAS 261
Cdd:PHA03247 2963 WLGALVPGRVAVPRFRVPQPAPSREAPAS 2991
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
50-462 |
1.95e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 41.92 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 50 ENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGH 129
Cdd:COG5271 580 ENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAE 659
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 130 AS-DSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPriSDSESEELPKPRVSDSESEDPPRPQA 208
Cdd:COG5271 660 ASaDESEEEAEDESETSSEDAEEDADAAAAEASDDEEETEEADEDAETASEE--ADAEEADTEADGTAEEAEEAAEEAES 737
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 209 SDSESEELPKPRVSDSESEDPPRPQASD-----SESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGE 283
Cdd:COG5271 738 ADEEAASLPDEADAEEEAEEAEEAEEDDadgleEALEEEKADAEEAATDEEAEAAAEEKEKVADEDQDTDEDALLDEAEA 817
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 284 NKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDeekvAKRKAAVLSDSEDDAGNASKKSRVVCDAD 363
Cdd:COG5271 818 DEEEDLDGEDEETADEALEDIEAGIAEDDEEDDDAAAAKDVDADLDL----DADLAADEHEAEEAQEAETDADADADAGE 893
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 364 DSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLE 443
Cdd:COG5271 894 ADSSGESSAAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEESDDAAADDAGDDSL 973
|
410
....*....|....*....
gi 569004601 444 EEKNETQLKEAEDSDSDDN 462
Cdd:COG5271 974 ADDDEALADAADDAEADDS 992
|
|
| PRK13108 |
PRK13108 |
prolipoprotein diacylglyceryl transferase; Reviewed |
57-210 |
2.30e-03 |
|
prolipoprotein diacylglyceryl transferase; Reviewed
Pssm-ID: 237284 [Multi-domain] Cd Length: 460 Bit Score: 41.12 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 57 EDGLAKIHNGTDSENDEPSNANAS-DSESEELHRPKDSDSD-SEEHAESPASDSENEPVNQHGSDSENeellNGHASDSE 134
Cdd:PRK13108 292 VDEALEREPAELAAAAVASAASAVgPVGPGEPNQPDDVAEAvKAEVAEVTDEVAAESVVQVADRDGES----TPAVEETS 367
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569004601 135 KEEVSKHAASDSEAEDTLQPQVSES-DSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDP-PRPQASD 210
Cdd:PRK13108 368 EADIEREQPGDLAGQAPAAHQVDAEaASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPgDDPAEPD 445
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
144-238 |
2.67e-03 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 40.88 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 144 SDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEelpkprvSDSESEdpprpQASDSESEElpkpRVSD 223
Cdd:pfam05110 422 SSSEDSDDDQAPEKPPPSSAPPSAPQSQPNSVASAHSSSGESGSS-------SDSESS-----SESDSESES----SSSD 485
|
90
....*....|....*
gi 569004601 224 SESEDPPRPQASDSE 238
Cdd:pfam05110 486 SEANEPPRSATPEPE 500
|
|
| PRK08581 |
PRK08581 |
amidase domain-containing protein; |
9-257 |
2.86e-03 |
|
amidase domain-containing protein;
Pssm-ID: 236304 [Multi-domain] Cd Length: 619 Bit Score: 40.93 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 9 DQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTgsvdhhSENETSDREDGLAKIHNGTDSEND-EPSNANASDSESEEL 87
Cdd:PRK08581 50 ETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDS------STSDSNNIIDFIYKNLPQTNINQLlTKNKYDDNYSLTTLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 88 HRPKDSDSDSEEHaESPASDSenepvnqHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRP 167
Cdd:PRK08581 124 QNLFNLNSDISDY-EQPRNSE-------KSTNDSNKNSDSSIKNDTDTQSSKQDKADNQKAPSSNNTKPSTSNKQPNSPK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 168 QASDSENEEPP-----KPRISDSESEELPKPRVSDS---ESEDPPRPQASDSESEElPKPRVSDSESEDPPRPQASDSES 239
Cdd:PRK08581 196 PTQPNQSNSQPasddtANQKSSSKDNQSMSDSALDSildQYSEDAKKTQKDYASQS-KKDKTETSNTKNPQLPTQDELKH 274
|
250
....*....|....*...
gi 569004601 240 EELPKPrvsDSESEDPQK 257
Cdd:PRK08581 275 KSKPAQ---SFENDVNQS 289
|
|
| PRK13108 |
PRK13108 |
prolipoprotein diacylglyceryl transferase; Reviewed |
102-281 |
3.60e-03 |
|
prolipoprotein diacylglyceryl transferase; Reviewed
Pssm-ID: 237284 [Multi-domain] Cd Length: 460 Bit Score: 40.73 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 102 ESPASDSENEPVNQHGSDSENEEL----LNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEP 177
Cdd:PRK13108 280 EAPGALRGSEYVVDEALEREPAELaaaaVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGES 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 178 PkPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVS----DSESEDPPRPQASDSESEelpkprvSDSESE 253
Cdd:PRK13108 360 T-PAVEETSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAAlaseAHDETEPEVPEKAAPIPD-------PAKPDE 431
|
170 180
....*....|....*....|....*...
gi 569004601 254 DPQKGPASDSEAEDASRHKEKPDSDDSD 281
Cdd:PRK13108 432 LAVAGPGDDPAEPDGIRRQDDFSSRRRR 459
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
30-317 |
3.67e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 40.75 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 30 EDGVTEQHSGSDTGSvdhhsENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDse 109
Cdd:TIGR00927 633 GDVAEAEHTGERTGE-----EGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEAD-- 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 110 nepvnqHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEE 189
Cdd:TIGR00927 706 ------HKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDED 779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 190 lpkprVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSE-SEDPQKGPASDSEAEDA 268
Cdd:TIGR00927 780 -----EGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQElNAENQGEAKQDEKGVDG 854
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 569004601 269 SRHKEKPDSDDSDGENKREDSEVQNESDghtdrkglhssDSEEEEPKRQ 317
Cdd:TIGR00927 855 GGGSDGGDSEEEEEEEEEEEEEEEEEEE-----------EEEEEEENEE 892
|
|
| PHA02664 |
PHA02664 |
hypothetical protein; Provisional |
206-317 |
4.45e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 177447 Cd Length: 534 Bit Score: 40.37 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 206 PQASDSESEELPKPrvsDSESEDPPRPQASDSESEELpkprvSDSESEDPQKGPASDSEAEDASRHKEKPDSDDS--DGE 283
Cdd:PHA02664 424 PADQDVEAEAHDEF---DQDPGAPAHADRADSDEDDM-----DEQESGDERADGEDDSDSSYSYSTTSSEDESDSadDSW 495
|
90 100 110
....*....|....*....|....*....|....
gi 569004601 284 NKREDSEVQNESDghtdrkGLHSSDSEEEEPKRQ 317
Cdd:PHA02664 496 GDESDSGIEHDDG------GVGQAIEEEEEEERA 523
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
46-467 |
5.31e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.51 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 46 DHHSENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEEL 125
Cdd:PTZ00121 1369 AEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE 1448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 126 LNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSEN--EEPPKPRISDSESEELPKprVSDSESEDP 203
Cdd:PTZ00121 1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKkaDEAKKAAEAKKKADEAKK--AEEAKKADE 1526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 204 PRPQASDSESEELPKprVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGE 283
Cdd:PTZ00121 1527 AKKAEEAKKADEAKK--AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEE 1604
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 284 NKREDSEVQNESDGHTDRKGLHssdSEEEEPKRQKIDSDDDEEKEGDEEKVAKrkaavlsDSEDDAGNASKKSRVVCDAD 363
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAEELK---KAEEEKKKVEQLKKKEAEEKKKAEELKK-------AEEENKIKAAEEAKKAEEDK 1674
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 364 DSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLI-ADIFGESGDEEEEEFTGFNQEdl 442
Cdd:PTZ00121 1675 KKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIkAEEAKKEAEEDKKKAEEAKKD-- 1752
|
410 420
....*....|....*....|....*
gi 569004601 443 EEEKNETQLKEAEDSDSDDNIKRGK 467
Cdd:PTZ00121 1753 EEEKKKIAHLKKEEEKKAEEIRKEK 1777
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
2-203 |
5.34e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 40.36 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSENDEPSNANASD 81
Cdd:TIGR00927 698 EIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKED 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESPAsdsENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAasDSEAEDTLQPQVSESDS 161
Cdd:TIGR00927 778 EDEGEIQAGEDGEMKGDEGAEGKV---EHEGETEAGEKDEHEGQSETQADDTEVKDETGEQ--ELNAENQGEAKQDEKGV 852
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEELPKPRvSDSESEDP 203
Cdd:TIGR00927 853 DGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEE-EEEENEEP 893
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
152-280 |
6.08e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 40.14 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 152 LQPQVSESDSEDPPRPQASDSE-NEEPPKPRISDSESEELPKPRVsdseSEDPPRPQASDSESEELPKPRVSDSesedPP 230
Cdd:NF033839 365 VKPQPEKPKPEVKPQPETPKPEvKPQPEKPKPEVKPQPEKPKPEV----KPQPEKPKPEVKPQPEKPKPEVKPQ----PE 436
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 569004601 231 RPQASDSESEELPKPRV-SDSESEDPQKGPASDSEAEDASRHKEKPDSDDS 280
Cdd:NF033839 437 KPKPEVKPQPEKPKPEVkPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNS 487
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
82-327 |
6.22e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 40.03 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 82 SESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQvSESDS 161
Cdd:PTZ00108 1150 KEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGS-DQEDD 1228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 162 EDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRpqasdseseELPKPRVSDSESEDPPRPQASDSESee 241
Cdd:PTZ00108 1229 EEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPK---------NAPKRVSAVQYSPPPPSKRPDGESN-- 1297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 242 lPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDsDGENKREDSEVQNESD--GHTDRKGLHSSDSEEEEPKRQKI 319
Cdd:PTZ00108 1298 -GGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARK-KKSKTRVKQASASQSSrlLRRPRKKKSDSSSEDDDDSEVDD 1375
|
....*...
gi 569004601 320 DSDDDEEK 327
Cdd:PTZ00108 1376 SEDEDDED 1383
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
72-465 |
6.73e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.12 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 72 DEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDT 151
Cdd:PTZ00121 1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK 1391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 152 LQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPR 231
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 232 PQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEK----PDSDDSDGENKREDSEVQNESDGHTDRKGLHSS 307
Cdd:PTZ00121 1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEakkaEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL 1551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 308 DSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASKKSRVVCDADDSDSDVVSDKSGKRETTVAsdSEE 387
Cdd:PTZ00121 1552 KKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK--KAE 1629
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 388 EAGKEESSVKKKEDKDLFGSDSESGNEEENLI-ADIFGESGDEEEEEFTGFNQEDLEEEKNETQL-KEAEDSDSDDNIKR 465
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIkAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALkKEAEEAKKAEELKK 1709
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
102-265 |
6.96e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.14 E-value: 6.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 102 ESPAS-DSENEPVNQ--HGSDSENEELLNGHASDSEKEEVSKHAAS-DSEAEDTL-----QPQVSESDSEDPPRPQASDS 172
Cdd:pfam03154 23 KQTASpDGRASPTNEdlRSSGRNSPSAASTSSNDSKAESMKKSSKKiKEEAPSPLksakrQREKGASDTEEPERATAKKS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 173 ENEEPPKPRI-SDSESEELPKPRVSDSESEDPPR-PQASDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDS 250
Cdd:pfam03154 103 KTQEISRPNSpSEGEGESSDGRSVNDEGSSDPKDiDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAAS 182
|
170
....*....|....*
gi 569004601 251 ESEDPQKGPASDSEA 265
Cdd:pfam03154 183 PPSPPPPGTTQAATA 197
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
139-255 |
7.41e-03 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 39.72 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 139 SKHAASDSEAEDTLQPQVSESDSEDPPRPQASdseneEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEElpk 218
Cdd:pfam05110 402 SKTLPTSQQGTSMLEDDLKLSSSEDSDDDQAP-----EKPPPSSAPPSAPQSQPNSVASAHSSSGESGSSSDSESSS--- 473
|
90 100 110
....*....|....*....|....*....|....*..
gi 569004601 219 prVSDSESEDpprpQASDSESEElpKPRVSDSESEDP 255
Cdd:pfam05110 474 --ESDSESES----SSSDSEANE--PPRSATPEPEPP 502
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
73-268 |
8.31e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 39.58 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 73 EPSNANASDSESEELHRPKDSDS---DSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAE 149
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAApaaPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569004601 150 DTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPR--------VSDSESEDPPRPQASDSESEELPKPRV 221
Cdd:PRK07764 678 PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPqaaqgasaPSPAADDPVPLPPEPDDPPDPAGAPAQ 757
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 569004601 222 SDSESEDPPRPQASDSESeelPKPRVSDSESEDPQKGPASDSEAEDA 268
Cdd:PRK07764 758 PPPPPAPAPAAAPAAAPP---PSPPSEEEEMAEDDAPSMDDEDRRDA 801
|
|
| |
