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Conserved domains on  [gi|568951710|ref|XP_006508416|]
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cell migration-inducing and hyaluronan-binding protein isoform X1 [Mus musculus]

Protein Classification

G8 and PANDER_like_TMEM2 domain-containing protein( domain architecture ID 10562737)

protein containing domains G8, PANDER_like_TMEM2, Mucin2_WxxW, and PANDER_like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PANDER_like super family cl19122
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 1205-1361 3.06e-96

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


The actual alignment was detected with superfamily member cd13941:

Pssm-ID: 473142  Cd Length: 157  Bit Score: 305.19  E-value: 3.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710 1205 KTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHGSFRNAILQGIPWQLFNYVAAIP 1284
Cdd:cd13941     1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568951710 1285 DNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKEKMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL 1361
Cdd:cd13941    81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 141-303 2.06e-93

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


:

Pssm-ID: 260112  Cd Length: 168  Bit Score: 297.70  E-value: 2.06e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  141 KYIGVDKGGTLELHGQKKLSWTFLNKT-LHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESERL 219
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  220 VQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGH----KGSA 295
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                  ....*...
gi 568951710  296 AARVFKLF 303
Cdd:cd13938   161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 47-165 2.03e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 125.41  E-value: 2.03e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710    47 SPGHNrdyqVHIGHGRKLLL-TSSATVHSITISGggKLVIKDHHEhIVLRTRYILIDdGGELHAGSALCPFEGNFSIVLY 125
Cdd:pfam10162    9 QPGDN----VVIPAGQTVLLdVSSPTLKSLVIQG--TLIFDDDKN-ITLRARYILVQ-GGRLIIGSEDCPFQGKATITLH 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568951710   126 GRADENILPDPYYGLKYIGVDKGGTLELHGQKKL-SWTFLN 165
Cdd:pfam10162   81 GRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 325-403 1.25e-13

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


:

Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 67.36  E-value: 1.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710   325 WTEWFDHDKvPQSKGG---EKISDLRAAypGKICNRPIDIQA----TTMDGVALSTEVVYKNgQDYRFACYTR---GRAC 394
Cdd:pfam13330    1 WTPWFDVDN-PSGSGGgdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTCD-VTTGLVCRNAdqqPDGC 76


                   ....*....
gi 568951710   395 RSYRVRFLC 403
Cdd:pfam13330   77 LDYEVRFLC 85
 
Name Accession Description Interval E-value
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1205-1361 3.06e-96

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 305.19  E-value: 3.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710 1205 KTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHGSFRNAILQGIPWQLFNYVAAIP 1284
Cdd:cd13941     1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568951710 1285 DNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKEKMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL 1361
Cdd:cd13941    81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 141-303 2.06e-93

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 297.70  E-value: 2.06e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  141 KYIGVDKGGTLELHGQKKLSWTFLNKT-LHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESERL 219
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  220 VQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGH----KGSA 295
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                  ....*...
gi 568951710  296 AARVFKLF 303
Cdd:cd13938   161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 47-165 2.03e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 125.41  E-value: 2.03e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710    47 SPGHNrdyqVHIGHGRKLLL-TSSATVHSITISGggKLVIKDHHEhIVLRTRYILIDdGGELHAGSALCPFEGNFSIVLY 125
Cdd:pfam10162    9 QPGDN----VVIPAGQTVLLdVSSPTLKSLVIQG--TLIFDDDKN-ITLRARYILVQ-GGRLIIGSEDCPFQGKATITLH 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568951710   126 GRADENILPDPYYGLKYIGVDKGGTLELHGQKKL-SWTFLN 165
Cdd:pfam10162   81 GRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 187-276 1.46e-31

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 118.90  E-value: 1.46e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710   187 RGVIVHVIDAKLGTVVHSDRFDTYrSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFR 266
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTY-SYSDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFR 79

                           90
                   ....*....|
gi 568951710   267 HPWSFITVKG 276
Cdd:pfam15711   80 DSWAFIGFKG 89
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1244-1329 5.09e-18

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 80.00  E-value: 5.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  1244 DGIQIVVIDGSRGHVVSHGSFRNaILQGIPWQLFNYVAAIPDNSIVLMASKGRYITR--GPWTRVLEKLGADKGLKL--K 1319
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDT-YSYSDSSRLANFLKSIPDGSIVLIATKDEASSKlsDEARKALESLGSSKIDNLgfR 79

                           90
                   ....*....|
gi 568951710  1320 EKMAFVGFKG 1329
Cdd:pfam15711   80 DSWAFIGFKG 89
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 325-403 1.25e-13

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 67.36  E-value: 1.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710   325 WTEWFDHDKvPQSKGG---EKISDLRAAypGKICNRPIDIQA----TTMDGVALSTEVVYKNgQDYRFACYTR---GRAC 394
Cdd:pfam13330    1 WTPWFDVDN-PSGSGGgdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTCD-VTTGLVCRNAdqqPDGC 76


                   ....*....
gi 568951710   395 RSYRVRFLC 403
Cdd:pfam13330   77 LDYEVRFLC 85
 
Name Accession Description Interval E-value
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1205-1361 3.06e-96

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 305.19  E-value: 3.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710 1205 KTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHGSFRNAILQGIPWQLFNYVAAIP 1284
Cdd:cd13941     1 KTKDHFLEVKIESYKTRYFHLKDDFAYIEVDGKKFFLSEDGIQVVVIDGHSGKVVDTTSFRNSILQGIPAQLENYVTNIK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568951710 1285 DNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKEKMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL 1361
Cdd:cd13941    81 DNSIVLITSKGRLVSRGPWTKVLEKLGADQGFKLKEKMAFVGFKGSFRPVWVKLVTDDEAAKIFQALPIPVVKKMKL 157
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 141-303 2.06e-93

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 297.70  E-value: 2.06e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  141 KYIGVDKGGTLELHGQKKLSWTFLNKT-LHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESERL 219
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTvLHPGLPKGGGYSFERSWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  220 VQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGH----KGSA 295
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSKEIDHLGYRQPWAFVGVKGGPSSAVEDRREYEGHsttgTALA 160


                  ....*...
gi 568951710  296 AARVFKLF 303
Cdd:cd13938   161 AREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 47-165 2.03e-33

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 125.41  E-value: 2.03e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710    47 SPGHNrdyqVHIGHGRKLLL-TSSATVHSITISGggKLVIKDHHEhIVLRTRYILIDdGGELHAGSALCPFEGNFSIVLY 125
Cdd:pfam10162    9 QPGDN----VVIPAGQTVLLdVSSPTLKSLVIQG--TLIFDDDKN-ITLRARYILVQ-GGRLIIGSEDCPFQGKATITLH 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 568951710   126 GRADENILPDPYYGLKYIGVDKGGTLELHGQKKL-SWTFLN 165
Cdd:pfam10162   81 GRPELDDDDGPNYGSKVIGVRNGGTLELHGQPPTvTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 187-276 1.46e-31

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 118.90  E-value: 1.46e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710   187 RGVIVHVIDAKLGTVVHSDRFDTYrSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFR 266
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTY-SYSDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFR 79

                           90
                   ....*....|
gi 568951710   267 HPWSFITVKG 276
Cdd:pfam15711   80 DSWAFIGFKG 89
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 175-292 1.99e-26

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 106.27  E-value: 1.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  175 EGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYrSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTK 254
Cdd:cd13936    19 NGGVLFDGDKSGRGINVVVINGDTGKVIATKTFDTY-GAGASNDMIDFLNSVPPGSIVLIATKDDASKSLKDEARRALES 97

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568951710  255 LGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGHK 292
Cdd:cd13936    98 LGSSLIQNLGFRDSWAFVGQKGIKRPSTEQHEISPKNS 135
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 1211-1361 2.77e-26

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 105.88  E-value: 2.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710 1211 LEVKMESSRQHffhlrnDFAYIEVDGRRY---PCSEDGIQIVVIDGSRGHVVSHGSFRNAIlQGIPWQLFNYVAAIPDNS 1287
Cdd:cd13936     1 LEVKIASGGGG------NYAKICVNGGVLfdgDKSGRGINVVVINGDTGKVIATKTFDTYG-AGASNDMIDFLNSVPPGS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710 1288 IVLMASKGRYITR--GPWTRVLEKLGADKGLKLK--EKMAFVGFKGSFRPIWvtletEDHKAKIFQV---VPIPVVRKKK 1360
Cdd:cd13936    74 IVLIATKDDASKSlkDEARRALESLGSSLIQNLGfrDSWAFVGQKGIKRPST-----EQHEISPKNSswgGPALIQTCFP 148


                  .
gi 568951710 1361 L 1361
Cdd:cd13936   149 L 149
PANDER_GnT-1_2_like cd13937
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ...
 187-281 1.65e-20

PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined.


Pssm-ID: 260111  Cd Length: 148  Bit Score: 89.28  E-value: 1.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  187 RGVIVHVIDAKLGTVVHSDRFDTYrSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFR 266
Cdd:cd13937    31 RGIHVVVLNQATGSVMAQRVFDTY-SPGEDEAMILFLNMVSDGRILIFTIKDEGSFHLKDEARSLLKKLGSQKVSKLGWR 109

                          90
                  ....*....|....*
gi 568951710  267 HPWSFITVKGNPSSS 281
Cdd:cd13937   110 DMWAMVTRKGGPVYG 124
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1244-1329 5.09e-18

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 80.00  E-value: 5.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  1244 DGIQIVVIDGSRGHVVSHGSFRNaILQGIPWQLFNYVAAIPDNSIVLMASKGRYITR--GPWTRVLEKLGADKGLKL--K 1319
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDT-YSYSDSSRLANFLKSIPDGSIVLIATKDEASSKlsDEARKALESLGSSKIDNLgfR 79

                           90
                   ....*....|
gi 568951710  1320 EKMAFVGFKG 1329
Cdd:pfam15711   80 DSWAFIGFKG 89
PANDER_FAM3B cd13939
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ...
 187-287 1.56e-14

Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver.


Pssm-ID: 260113  Cd Length: 175  Bit Score: 73.03  E-value: 1.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  187 RGVIVHVIDAKLGTVVHSDRFDTYRSKKeSERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFR 266
Cdd:cd13939    49 RGINIAVVSYETGKVVATKYFDMYEGDF-SGPMIEFINKIPKKSLVFVVTHDDGSTKLKDPAKKAIEDLGSKEIRNLKFR 127

                          90       100
                  ....*....|....*....|.
gi 568951710  267 HPWSFITVKGnpsSSVEDHIE 287
Cdd:cd13939   128 SAWVFIAAKG---FQLPDNIE 145
Mucin2_WxxW pfam13330
Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. ...
 325-403 1.25e-13

Mucin-2 protein WxxW repeating region; This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.


Pssm-ID: 463846 [Multi-domain]  Cd Length: 85  Bit Score: 67.36  E-value: 1.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710   325 WTEWFDHDKvPQSKGG---EKISDLRAAypGKICNRPIDIQA----TTMDGVALSTEVVYKNgQDYRFACYTR---GRAC 394
Cdd:pfam13330    1 WTPWFDVDN-PSGSGGgdfETLENLRAY--GKFCENPTDIECraepPTGVPASETGQVVTCD-VTTGLVCRNAdqqPDGC 76


                   ....*....
gi 568951710   395 RSYRVRFLC 403
Cdd:pfam13330   77 LDYEVRFLC 85
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 187-286 3.13e-13

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 69.22  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951710  187 RGVIVHVIDAKLGTVVHSDRFDTYrsKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFR 266
Cdd:cd13940    50 RGLNIALVNGETGEVLKTGFFDMY--SGDVKPLLEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFR 127

                          90       100
                  ....*....|....*....|.
gi 568951710  267 HPWSFITVKGNPS-SSVEDHI 286
Cdd:cd13940   128 DNWVFVGGKGIKTkSPFEKHI 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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