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Conserved domains on  [gi|568934217|ref|XP_006504015|]
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leucine-rich repeat-containing protein 66 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-263 3.37e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 3.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  98 LAHLHALEILNLSNKAIHyfSLDQPLppsshqkrhgghshSRLPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNRIV 177
Cdd:COG4886  132 LANLTNLKELDLSNNQLT--DLPEPL--------------GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 178 HIGLSdFHGCLQLESIYLKSNKICTIhPKAFKGLKKLQVVDLRSNALTTLVPIvtiaLELPHLE-LGLADNQWQCSESNV 256
Cdd:COG4886  196 DLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPEL----GNLTNLEeLDLSNNQLTDLPPLA 269


                 ....*..
gi 568934217 257 NFQNITS 263
Cdd:COG4886  270 NLTNLKT 276
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-263 3.37e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 3.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  98 LAHLHALEILNLSNKAIHyfSLDQPLppsshqkrhgghshSRLPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNRIV 177
Cdd:COG4886  132 LANLTNLKELDLSNNQLT--DLPEPL--------------GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 178 HIGLSdFHGCLQLESIYLKSNKICTIhPKAFKGLKKLQVVDLRSNALTTLVPIvtiaLELPHLE-LGLADNQWQCSESNV 256
Cdd:COG4886  196 DLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPEL----GNLTNLEeLDLSNNQLTDLPPLA 269


                 ....*..
gi 568934217 257 NFQNITS 263
Cdd:COG4886  270 NLTNLKT 276
LRR_8 pfam13855
Leucine rich repeat;
165-224 3.22e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.22e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  165 SLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVVDLRSNAL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-204 3.48e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  87 HHRISKvtLDPLAHLHALEILNLSNKAI---------------HyfsLD-QPLPPsshqkrhgGHS--------HSRLPR 142
Cdd:cd21340   55 NNQIEK--IENLENLVNLKKLYLGGNRIsvveglenltnleelH---IEnQRLPP--------GEKltfdprslAALSNS 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934217 143 LQVLILQRNQLSgTPKGLWKLKSLRSLDLSFNRIVHIG--LSDFHGCLQLESIYLKSNKICTIH 204
Cdd:cd21340  122 LRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-229 5.35e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 116 YFSLDQPLPPSShqkrhgghshSRLPRLQVLILQRNQLSGT-PKGLWKLKSLRSLDLSFNRIVHiGLSDFHGCLQ-LESI 193
Cdd:PLN00113 245 YNNLTGPIPSSL----------GNLKNLQYLFLYQNKLSGPiPPSIFSLQKLISLDLSDNSLSG-EIPELVIQLQnLEIL 313

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568934217 194 YLKSNKICTIHPKAFKGLKKLQVVDLRSNALTTLVP 229
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIP 349
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-263 3.37e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 3.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  98 LAHLHALEILNLSNKAIHyfSLDQPLppsshqkrhgghshSRLPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNRIV 177
Cdd:COG4886  132 LANLTNLKELDLSNNQLT--DLPEPL--------------GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 178 HIGLSdFHGCLQLESIYLKSNKICTIhPKAFKGLKKLQVVDLRSNALTTLVPIvtiaLELPHLE-LGLADNQWQCSESNV 256
Cdd:COG4886  196 DLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPEL----GNLTNLEeLDLSNNQLTDLPPLA 269


                 ....*..
gi 568934217 257 NFQNITS 263
Cdd:COG4886  270 NLTNLKT 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-248 3.25e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 3.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  96 DPLAHLHALEILNLSNKAIhyfsldQPLPPsshqkrhgghSHSRLPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNR 175
Cdd:COG4886  107 EELSNLTNLESLDLSGNQL------TDLPE----------ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ 170

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934217 176 IVHIGlSDFHGCLQLESIYLKSNKICTIhPKAFKGLKKLQVVDLRSNALTTLVPIVTialELPHLE-LGLADNQ 248
Cdd:COG4886  171 LTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLA---NLTNLEtLDLSNNQ 239
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-227 1.55e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  96 DPLAHLHALEILNLSNKAIHyfSLDQPLppsshqkrhgghshSRLPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNR 175
Cdd:COG4886  176 EELGNLTNLKELDLSNNQIT--DLPEPL--------------GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568934217 176 IVHigLSDFHGCLQLESIYLKSNKICTIHPkaFKGLKKLQVVDLRSNALTTL 227
Cdd:COG4886  240 LTD--LPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
165-224 3.22e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.22e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  165 SLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVVDLRSNAL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-248 9.65e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 9.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 138 SRLPRLQVLILQRNqlsgtpKGLWKLKSLRSLDLSFNRIVHIGlSDFHGCLQLESIYLKSNKICTIhPKAFKGLKKLQVV 217
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568934217 218 DLRSNALTTL-VPIvtiaLELPHLE-LGLADNQ 248
Cdd:COG4886  165 DLSNNQLTDLpEEL----GNLTNLKeLDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
141-200 2.59e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.59e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934217  141 PRLQVLILQRNQLSGTPKGLWK-LKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKI 200
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
189-248 2.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568934217  189 QLESIYLKSNKICTIHPKAFKGLKKLQVVDLRSNALTTLVPivtIALE-LPHLE-LGLADNQ 248
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP---GAFSgLPSLRyLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-200 1.92e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  96 DPLAHLHALEILNLSNKAIHYF-SLdqplppsshqkrhgghshSRLPRLQVLILQRNQLSGTPKgLWKLKSLRSLDLSFN 174
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLpEL------------------GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNN 282

                         90       100
                 ....*....|....*....|....*.
gi 568934217 175 RIVHIGLSDFHGCLQLESIYLKSNKI 200
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-204 3.48e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  87 HHRISKvtLDPLAHLHALEILNLSNKAI---------------HyfsLD-QPLPPsshqkrhgGHS--------HSRLPR 142
Cdd:cd21340   55 NNQIEK--IENLENLVNLKKLYLGGNRIsvveglenltnleelH---IEnQRLPP--------GEKltfdprslAALSNS 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934217 143 LQVLILQRNQLSgTPKGLWKLKSLRSLDLSFNRIVHIG--LSDFHGCLQLESIYLKSNKICTIH 204
Cdd:cd21340  122 LRVLNISGNNID-SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 138-272 4.70e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 4.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 138 SRLPRLQVLILQRNQLSgtpK--GLWKLKSLRSLDLSFNRIVHI-GLsdfHGCLQLESIYLKSNKIC-----TIHPKAFK 209
Cdd:cd21340   43 EFLTNLTHLYLQNNQIE---KieNLENLVNLKKLYLGGNRISVVeGL---ENLTNLEELHIENQRLPpgeklTFDPRSLA 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568934217 210 GLKK-LQVVDLRSNALTTLVPIVTialeLPHLE-LGLADNQWQcsesnvNFQNITS--SSWREIWKA 272
Cdd:cd21340  117 ALSNsLRVLNISGNNIDSLEPLAP----LRNLEqLDASNNQIS------DLEELLDllSSWPSLREL 173
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 138-247 2.61e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 138 SRLPRLQVLILQRNQLSGTP-----KGLWKLKSLRSLDLSFNRIVHIGLS----DFHGCLQLESIYLKSNKICTIHPKA- 207
Cdd:cd00116  134 DLPPALEKLVLGRNRLEGAScealaKALRANRDLKELNLANNGIGDAGIRalaeGLKANCNLEVLDLNNNGLTDEGASAl 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568934217 208 ---FKGLKKLQVVDLRSNALtTLVPIVTIALELPH-----LELGLADN 247
Cdd:cd00116  214 aetLASLKSLEVLNLGDNNL-TDAGAAALASALLSpnislLTLSLSCN 260
LRR_8 pfam13855
Leucine rich repeat;
104-176 4.46e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934217  104 LEILNLSNKAIHyfSLDQplppsshqkrhggHSHSRLPRLQVLILQRNQLSG-TPKGLWKLKSLRSLDLSFNRI 176
Cdd:pfam13855   3 LRSLDLSNNRLT--SLDD-------------GAFKGLSNLKVLDLSNNLLTTlSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 116-229 5.35e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 116 YFSLDQPLPPSShqkrhgghshSRLPRLQVLILQRNQLSGT-PKGLWKLKSLRSLDLSFNRIVHiGLSDFHGCLQ-LESI 193
Cdd:PLN00113 245 YNNLTGPIPSSL----------GNLKNLQYLFLYQNKLSGPiPPSIFSLQKLISLDLSDNSLSG-EIPELVIQLQnLEIL 313

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568934217 194 YLKSNKICTIHPKAFKGLKKLQVVDLRSNALTTLVP 229
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIP 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 140-248 7.64e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 140 LPRLQVLILQRNQLSGTPKGLWKLKSLRSLDLSFNRI---VHIGLSDFHGCLQLEsiyLKSNKICTIHPKAFKGLKKLQV 216
Cdd:PLN00113 451 MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFsgaVPRKLGSLSELMQLK---LSENKLSGEIPDELSSCKKLVS 527

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568934217 217 VDLRSNALTTLVPiVTIAlELPHL-ELGLADNQ 248
Cdd:PLN00113 528 LDLSHNQLSGQIP-ASFS-EMPVLsQLDLSQNQ 558
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-229 7.84e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 138 SRLPRLQVLILQRNQLSGT-PKGLWKLKSLRSLDLSFNRIVHiGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQV 216
Cdd:PLN00113 425 TKLPLVYFLDISNNNLQGRiNSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503

                         90
                 ....*....|...
gi 568934217 217 VDLRSNALTTLVP 229
Cdd:PLN00113 504 LKLSENKLSGEIP 516
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-229 1.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 138 SRLPRLQVLILQRNQLSGT-PKGLWKLKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQV 216
Cdd:PLN00113 472 FGSKRLENLDLSRNQFSGAvPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551

                         90
                 ....*....|...
gi 568934217 217 VDLRSNALTTLVP 229
Cdd:PLN00113 552 LDLSQNQLSGEIP 564
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 141-177 1.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568934217  141 PRLQVLILQRNQLSGTPkGLWKLKSLRSLDLSFNRIV 177
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKI 36
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-249 1.59e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  98 LAHLHALEILNL-SNKaihyFSLDQPLPPSShqkrhgghshsrLPRLQVLILQRNQLSG-TPKGLWKLKSLRSLDLSFNR 175
Cdd:PLN00113 304 VIQLQNLEILHLfSNN----FTGKIPVALTS------------LPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 176 I---VHIGLSD---------------------FHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVVDLRSNALTTlvPIV 231
Cdd:PLN00113 368 LtgeIPEGLCSsgnlfklilfsnslegeipksLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG--RIN 445

                        170
                 ....*....|....*....
gi 568934217 232 TIALELPHLE-LGLADNQW 249
Cdd:PLN00113 446 SRKWDMPSLQmLSLARNKF 464
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-240 2.56e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 139 RLPRLQVLILQRNQLSG-TPKGLWKLKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVV 217
Cdd:PLN00113 210 QMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                         90       100
                 ....*....|....*....|....*.
gi 568934217 218 DLRSNALTTLVPIVTI---ALELPHL 240
Cdd:PLN00113 290 DLSDNSLSGEIPELVIqlqNLEILHL 315
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-226 1.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217  86 THHRISKVTLDPLA----HLHALEILNLSNKAIHYF---SLDQPLPPSSHqkrhgghshsrlprLQVLILQRNQLsgTPK 158
Cdd:cd00116  145 GRNRLEGASCEALAkalrANRDLKELNLANNGIGDAgirALAEGLKANCN--------------LEVLDLNNNGL--TDE 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934217 159 G-------LWKLKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKS-----NKICTIHPKAFKGL----KKLQVVDLRSN 222
Cdd:cd00116  209 GasalaetLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTlslscNDITDDGAKDLAEVlaekESLLELDLRGN 288


                 ....
gi 568934217 223 ALTT 226
Cdd:cd00116  289 KFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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