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Conserved domains on  [gi|564373454|ref|XP_006247057|]
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notchless protein homolog 1 isoform X1 [Rattus norvegicus]

Protein Classification

WDR12/YTM1 family ribosome biogenesis protein( domain architecture ID 10548159)

WDR12/YTM1 family ribosome biogenesis protein is required for maturation of ribosomal RNAs and the formation of the ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042273|GO:0005515
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
108-486 1.34e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 275.37  E-value: 1.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 108 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDP 187
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 188 STGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 266
Cdd:cd00200   81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 346
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 347 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 426
Cdd:cd00200  185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 427 DSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
19-79 3.68e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated yeast ribosome biogenesis protein YTM1.


:

Pssm-ID: 429846  Cd Length: 67  Bit Score: 67.19  E-value: 3.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454   19 LLVQFQDEGGQLL----GSPFDVPVDITPDQLQLVCNALLAQDE--PLPLAFYVHDAEIVSSLGKTL 79
Cdd:pfam08154   1 VQVRFVTKDEGESlavpGTPLDVPASLTRYQLSELVNSLLENEEekPVPFDFLINGEFLRTSLEEHL 67
PTZ00420 super family cl36561
coronin; Provisional
344-402 1.23e-04

coronin; Provisional


The actual alignment was detected with superfamily member PTZ00420:

Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454 344 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 402
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
108-486 1.34e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 275.37  E-value: 1.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 108 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDP 187
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 188 STGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 266
Cdd:cd00200   81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 346
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 347 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 426
Cdd:cd00200  185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 427 DSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-487 7.40e-62

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 209.17  E-value: 7.40e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 109 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFT--CKGHRHWVLSISW-SPDGKKLASGCK--NGQIL 183
Cdd:COG2319   58 SLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKslEGLHDSSVSKLALsSPDGNSILLASSslDGTVK 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 184 LWDPSTGTQVGRTLTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLY 263
Cdd:COG2319  138 LWDLSTPGKLIRTLEGHSESVTSLAFSPDGKL----LASGSSLDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLL 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 264 --SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTmALSTDYALRTGAFEPAEATV-NAQDLQGSLKELKERASSRYNLVR 339
Cdd:COG2319  214 iaSGSSDGTIRLWDLSTGKLLRsTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLwDLRSSSSLLRTLSGHSSSVLSVAF 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 340 GQGPERLVSGSDDFTLFLWSPAEDKKPLAR-MTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGRTGKYLASLRGHVA 417
Cdd:COG2319  293 SPDGKLLASGSSDGTVRLWDLETGKLLSSLtLKGHEGPVSSLSFSPDgSLLVSGGSDDGTIRLWDLRTGKPLKTLEGHSN 372
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 418 aVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 487
Cdd:COG2319  373 -VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDL 441
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
19-79 3.68e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated yeast ribosome biogenesis protein YTM1.


Pssm-ID: 429846  Cd Length: 67  Bit Score: 67.19  E-value: 3.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454   19 LLVQFQDEGGQLL----GSPFDVPVDITPDQLQLVCNALLAQDE--PLPLAFYVHDAEIVSSLGKTL 79
Cdd:pfam08154   1 VQVRFVTKDEGESlavpGTPLDVPASLTRYQLSELVNSLLENEEekPVPFDFLINGEFLRTSLEEHL 67
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
107-144 1.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564373454   107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
161-445 1.75e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 233
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 234 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 307
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 308 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 380
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 381 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 445
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
107-144 2.56e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564373454  107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
344-402 1.23e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454 344 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 402
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
116-211 2.18e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 40.33  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454  116 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA---SGCKNGQI 182
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLAvslSKDGNPDI 260
                          90       100
                  ....*....|....*....|....*....
gi 564373454  183 LLWDPSTGTQvgRTLTGHSKWITGLSWEP 211
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
108-486 1.34e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 275.37  E-value: 1.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 108 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWDP 187
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 188 STGTQVgRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSAS 266
Cdd:cd00200   81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 267 QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAlstdyalrtgafepaeatvnaqdlqgslkelkerassrynlvrgqgperl 346
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVA-------------------------------------------------- 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 347 vsgsddftlflwspaedkkplarmtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA 426
Cdd:cd00200  185 -----------------------------------FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 427 DSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 486
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-487 7.40e-62

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 209.17  E-value: 7.40e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 109 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFT--CKGHRHWVLSISW-SPDGKKLASGCK--NGQIL 183
Cdd:COG2319   58 SLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKslEGLHDSSVSKLALsSPDGNSILLASSslDGTVK 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 184 LWDPSTGTQVGRTLTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDGLLY 263
Cdd:COG2319  138 LWDLSTPGKLIRTLEGHSESVTSLAFSPDGKL----LASGSSLDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLL 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 264 --SASQDRTIKVWRAHDGVLCR-TLQGHGHWVNTmALSTDYALRTGAFEPAEATV-NAQDLQGSLKELKERASSRYNLVR 339
Cdd:COG2319  214 iaSGSSDGTIRLWDLSTGKLLRsTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLwDLRSSSSLLRTLSGHSSSVLSVAF 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 340 GQGPERLVSGSDDFTLFLWSPAEDKKPLAR-MTGHQALINQVLFSPD-SRIVASASFDKSIKLWDGRTGKYLASLRGHVA 417
Cdd:COG2319  293 SPDGKLLASGSSDGTVRLWDLETGKLLSSLtLKGHEGPVSSLSFSPDgSLLVSGGSDDGTIRLWDLRTGKPLKTLEGHSN 372
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 418 aVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 487
Cdd:COG2319  373 -VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDL 441
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
107-301 2.35e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.08  E-value: 2.35e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTGtQVGRTLTGHSKWITGLSWEPlhmnPECRYVASSSkDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 265
Cdd:cd00200  164 LRTG-KCVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASG 237
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 564373454 266 SQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 301
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 COG2319
WD40 repeat [General function prediction only];
99-480 7.69e-54

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 187.60  E-value: 7.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454  99 VFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSG-DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKK-LASG 176
Cdd:COG2319  138 LWDLSTPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLlIASG 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 177 CKNGQILLWDPSTGTQVGRTLTGHSKWITGLsweplhMNPECRYVASSSKDGSVRVWDT-TAGRCERILTGHTQSVTCLR 255
Cdd:COG2319  218 SSDGTIRLWDLSTGKLLRSTLSGHSDSVVSS------FSPDGSLLASGSSDGTIRLWDLrSSSSLLRTLSGHSSSVLSVA 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 256 WGGDG-LLYSASQDRTIKVW--RAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeatvnaqdlqgslkelkeras 332
Cdd:COG2319  292 FSPDGkLLASGSSDGTVRLWdlETGKLLSSLTLKGHEGPVSSLSFSPD-------------------------------- 339
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 333 srynlvrgqGPERLVSGSDDFTLFLWSPAEDKKPLARMTGHQalINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASL 412
Cdd:COG2319  340 ---------GSLLVSGGSDDGTIRLWDLRTGKPLKTLEGHSN--VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNL 408
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 413 RGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKaqklttdlpghaDEVYAVDWSPDGQRVASGGKDK 480
Cdd:COG2319  409 DGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDLK------------TSLKSVSFSPDGKVLASKSSDL 464
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
107-275 5.83e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 177.53  E-value: 5.83e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 187 PSTGTQVGrTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSA 265
Cdd:cd00200  206 LSTGKCLG-TLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279
                        170
                 ....*....|
gi 564373454 266 SQDRTIKVWR 275
Cdd:cd00200  280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
106-439 2.45e-39

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 148.31  E-value: 2.45e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 106 TRCTSSLEGHSEAVISVAFSPTGK-YLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSiSWSPDGKKLASGCKNGQIL 183
Cdd:COG2319  188 GKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTgKLLRSTLSGHSDSVVS-SFSPDGSLLASGSSDGTIR 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 184 LWDPSTGTQVGRTLTGHSKWITGLSWEPLHmnpecRYVASSSKDGSVRVWDTTAGRCERILT--GHTQSVTCLRWGGDG- 260
Cdd:COG2319  267 LWDLRSSSSLLRTLSGHSSSVLSVAFSPDG-----KLLASGSSDGTVRLWDLETGKLLSSLTlkGHEGPVSSLSFSPDGs 341
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 261 -LLYSASQDRTIKVWRAHDGvLCRTLQGHGHWVNTMALSTDYalrtgafepaeatvnaqdlqgslkelkerassrynlvr 339
Cdd:COG2319  342 lLVSGGSDDGTIRLWDLRTG-KPLKTLEGHSNVLSVSFSPDG-------------------------------------- 382
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 340 gqgpERLVSGSDDFTLFLWSPaEDKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGkylaslrghvaaV 419
Cdd:COG2319  383 ----RVVSSGSTDGTVRLWDL-STGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDLKTS------------L 445
                        330       340
                 ....*....|....*....|
gi 564373454 420 YQIAWSADSRLLVSGSSDST 439
Cdd:COG2319  446 KSVSFSPDGKVLASKSSDLS 465
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
19-79 3.68e-14

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated yeast ribosome biogenesis protein YTM1.


Pssm-ID: 429846  Cd Length: 67  Bit Score: 67.19  E-value: 3.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454   19 LLVQFQDEGGQLL----GSPFDVPVDITPDQLQLVCNALLAQDE--PLPLAFYVHDAEIVSSLGKTL 79
Cdd:pfam08154   1 VQVRFVTKDEGESlavpGTPLDVPASLTRYQLSELVNSLLENEEekPVPFDFLINGEFLRTSLEEHL 67
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
107-144 1.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564373454   107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
405-444 1.27e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564373454   405 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 444
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
161-445 1.75e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.10  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVGR-------TLTGHSKwITGLSWEPlHMNPEcryVASSSKDGSVRVW 233
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvvELASRSK-LSGICWNS-YIKSQ---VASSNFEGVVQVW 560
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 234 DTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAHDGVLCRTLQGHGHwVNTMALSTDYAlRTGA 307
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESG-RSLA 634
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 308 FEPAEATVNAQDLQGSLKELKERA--SSRYNLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLARMTGHQALINQV 380
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsISGINETPLHSFMGHTNVKNFV 714
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 381 LFSPDSRIVASAS-----------FDKSIKLWDGRTGKYLASLRGHVAA--VYQIAWSADSRLLVSGSSDSTLKVWDV 445
Cdd:PLN00181 715 GLSVSDGYIATGSetnevfvyhkaFPMPVLSYKFKTIDPVSGLEVDDASqfISSVCWRGQSSTLVAANSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
107-144 2.56e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564373454  107 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 144
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
147-186 3.12e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 3.12e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564373454   147 TETPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
343-458 4.70e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 4.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 343 PERLVSGSDDFTLFLWS-PAEDKK-----PLARMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 415
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564373454 416 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLTTDLPGHA 458
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PTZ00421 PTZ00421
coronin; Provisional
98-278 1.64e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454  98 AVFRVRAVTRCTSS---LEGHSEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHFTCKGHRHWVLSISW 166
Cdd:PTZ00421  54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 167 SPDGKK-LASGCKNGQILLWDPSTGTqVGRTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWDTTAGRCERILT 245
Cdd:PTZ00421 134 HPSAMNvLASAGADMVVNVWDVERGK-AVEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE 207
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564373454 246 GH--TQSVTCLrWGGDGLL-----YSASQDRTIKVWRAHD 278
Cdd:PTZ00421 208 AHasAKSQRCL-WAKRKDLiitlgCSKSQQRQIMLWDTRK 246
WD40 pfam00400
WD domain, G-beta repeat;
406-444 2.04e-08

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.04e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564373454  406 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 444
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
363-402 4.30e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564373454   363 DKKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 402
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
161-288 4.82e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 4.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 161 VLSISWSP-DGKKLASGCKNGQILLWD-PSTGTQVGRT-----LTGHSKWITGLSWEPLHMNpecrYVASSSKDGSVRVW 233
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564373454 234 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 288
Cdd:PTZ00421 154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
449-485 5.50e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 5.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 564373454   449 KLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
364-402 1.50e-07

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.50e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 564373454  364 KKPLARMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 402
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
372-484 1.74e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 372 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 442
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564373454 443 WDVKAQKLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 484
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
449-485 1.77e-07

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.77e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 564373454  449 KLTTDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 485
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
238-274 2.12e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 564373454   238 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 274
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
195-234 4.56e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.56e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 564373454   195 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 234
Cdd:smart00320   6 KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
149-186 5.01e-07

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564373454  149 TPHFTCKGHRHWVLSISWSPDGKKLASGCKNGQILLWD 186
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
131-274 6.49e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 6.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 131 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP-DGKKLASGCKNGQILLWDPSTGTQVGRTLTGHSKWITGLSW 209
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564373454 210 EplhmnpECRYVASSSKDGSVRVWDTTAGR---CERIltGHTQSVTCLRWGGDGLLYSASQDRTIKVW 274
Cdd:PLN00181 628 E------SGRSLAFGSADHKVYYYDLRNPKlplCTMI--GHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
238-274 6.99e-07

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.99e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564373454  238 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
195-234 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 564373454  195 RTLTGHSKWITGLSWeplhmNPECRYVASSSKDGSVRVWD 234
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
161-209 2.01e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.73  E-value: 2.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 564373454  161 VLSISWSPDGKKLASGCKNGQILLWDPSTGTQVgRTLTGHSKWITGLSW 209
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
376-485 3.78e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 376 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 447
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 564373454 448 QKLTTDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 485
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
TolB COG0823
Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, ...
116-233 1.01e-05

Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 223893 [Multi-domain]  Cd Length: 425  Bit Score: 47.83  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 116 SEAVISVAFSPTGKYLA----SGSGDTTVRFWDLSTETPH--FTCKGHrhwVLSISWSPDGKKLA-SGCKNG--QILLWD 186
Cdd:COG0823  192 GSLILTPAWSPDGKKLAyvsfELGGCPRIYYLDLNTGKRPviLNFNGN---NGAPAFSPDGSKLAfSSSRDGspDIYLMD 268
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564373454 187 PSTGTQVGrtLTGHSKWITGLSWeplhmNPECRYVA-SSSKDGSVRVW 233
Cdd:COG0823  269 LDGKNLPR--LTNGFGINTSPSW-----SPDGSKIVfTSDRGGRPQIY 309
PTZ00420 PTZ00420
coronin; Provisional
112-306 6.19e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 112 LEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWdlstETPHftckgHRHWVLSISwspdgkklasgckngqillwDPSTg 190
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW----EIPH-----NDESVKEIK--------------------DPQC- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 191 tqvgrTLTGHSKWITGLSWEPLHMNPECryvaSSSKDGSVRVWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QD 268
Cdd:PTZ00420 120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVG 188
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 564373454 269 RTIKVWRAHDGVLCRTLQGHGH-------WVNTMALSTDYALRTG 306
Cdd:PTZ00420 189 KHMHIIDPRKQEIASSFHIHDGgkntkniWIDGLGGDDNYILSTG 233
PTZ00420 PTZ00420
coronin; Provisional
364-449 8.61e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454 364 KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 434
Cdd:PTZ00420  64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143
                         90
                 ....*....|....*.
gi 564373454 435 SS-DSTLKVWDVKAQK 449
Cdd:PTZ00420 144 SGfDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
344-402 1.23e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.23e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564373454 344 ERLVSGSDDFTLFLWS-PAED------KKPLARMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 402
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
109-167 6.34e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 6.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 564373454  109 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 167
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
116-211 2.18e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 40.33  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564373454  116 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGKKLA---SGCKNGQI 182
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLAvslSKDGNPDI 260
                          90       100
                  ....*....|....*....|....*....
gi 564373454  183 LLWDPSTGTQvgRTLTGHSKWITGLSWEP 211
Cdd:TIGR02800 261 YVMDLDGKQL--TRLTNGPGIDTEPSWSP 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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