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hexokinase-2 isoform X1 [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
PLN02914 super family
cl42853
hexokinase
12-460
5.70e-118
hexokinase
The actual alignment was detected with superfamily member PTZ00107 :Pssm-ID: 456198 [Multi-domain]
Cd Length: 464
Bit Score: 368.23
E-value: 5.70e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 12 TELNHD Q VQKVDQYLYHMRL S D E T L L E ISKR F RK E MEK GL - GATT H PTA ------ AV KML PTF V RST P D G T E H G EFL A L D 84
Cdd:PTZ00107 1 EMRYIK Q RVRLASLVNQFTM S K E K L K E LVDY F LY E LVE GL e AHRR H RNL wipnec SF KML DSC V YNL P T G K E K G VYY A I D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 85 L GGTNFR VLW V KVTDN G lq K V E MENQIYAI P EDIMR G --------- SG T Q LFDHIA ECLANF M DKLQIKD --- K KL P L GF 152
Cdd:PTZ00107 81 F GGTNFR AVR V SLRGG G -- K M E RTQSKFSL P KSALL G ekglldkka TA T D LFDHIA KSIKKM M EENGDPE dln K PV P V GF 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPC H Q TKLDESF L VS WTKGF KSS ----- G VEG R DV VA L IRK A IQ R RG d FDIDI VAV V NDTVGT MMT C G Y DDH ---- N 223
Cdd:PTZ00107 159 TFSFPC T Q LSVNNAI L ID WTKGF ETG ratnd P VEG K DV GE L LND A FK R NN - VPANV VAV L NDTVGT LIS C A Y QKP kntp P 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 C EI G L I V GTGSNACY M E emrhi DM V E -- G DE G RM c INME W G A F gd D GS L N di R T EF D Q E I D MGSL N P G K Q L FEKMISG M Y 301
Cdd:PTZ00107 238 C QV G V I I GTGSNACY F E ----- PE V S ay G YA G TP - INME C G N F -- D SK L P -- I T PY D L E M D WYTP N R G R Q Q FEKMISG A Y 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 M GE LV R LIL V KMAKE ellfgg K LS P ELLNT G R FE TK D I S D I EGEK - DGIRKA R E V LMRL - GL D P T Q ED CVATHR IC QI V S 379
Cdd:PTZ00107 308 L GE IS R RLI V HLLQL ------ K AP P KMWQS G S FE SE D A S M I LNDQ s PDLQFS R Q V IKEA w DV D L T D ED LYTIRK IC EL V R 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 T R S A S L C AA TL AA VLQRIKENK G eerl RS T IGV DGSVY K K H P H F AKR L HKTVRRLV -- PGCD V R F LRSE DGSGKGAA MVT 457
Cdd:PTZ00107 382 G R A A Q L A AA FI AA PAKKTRTVQ G ---- KA T VAI DGSVY V K N P W F RRL L QEYINSIL gp DAGN V V F YLAD DGSGKGAA IIA 457
...
gi 530367515 458 A VA 460
Cdd:PTZ00107 458 A MV 460
Hexokinase_2
pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928
1.00e-108
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
:Pssm-ID: 427467
Cd Length: 238
Bit Score: 335.23
E-value: 1.00e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 694 EV GLI V GTG S NA C Y M E EMR N VELV EG --- EE G R M CV N M EWGAFGDNG C L DDF RTE F D VAV D EL S L NPG K Q R FEKMISGMY 770
Cdd:pfam03727 1 RI GLI L GTG T NA A Y V E KVS N IPKL EG klp KS G E M II N T EWGAFGDNG L L PLP RTE Y D KEL D AE S P NPG F Q P FEKMISGMY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 771 LGE I VR NI L I D FTKR GLLF R G RIS E R LKT RGIFE T K FLS Q IESD - CLA L LQV R A IL Q - H LG L E S - T CD D SI IV KEV C TV V 847
Cdd:pfam03727 81 LGE L VR LV L L D LAEE GLLF G G QLP E K LKT PYSLD T S FLS A IESD p SED L ETT R E IL E e L LG I E T c T EE D RK IV RRI C EA V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 848 AR RAA Q L CG AG M AA VVDR I REN R gldalk VTVGVDG TL Y KLH P H F AKVMH E TVKD L AP --- KCD V SFLQS EDGSG K GAAL 924
Cdd:pfam03727 161 ST RAA R L VA AG I AA ILKK I GGG R ------ VTVGVDG SV Y EKY P G F RERLQ E ALRE L LG pel EDK V VLVLA EDGSG V GAAL 234
....
gi 530367515 925 I T AV 928
Cdd:pfam03727 235 I A AV 238
Hexokinase_1
pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688
4.45e-88
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.
:Pssm-ID: 425627 [Multi-domain]
Cd Length: 197
Bit Score: 279.01
E-value: 4.45e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 471 QKT L EHLQ LS HDQ L L E VKR R MKV EME R GL S KE THA S ap V KMLPTYV CAT P D GTEKG D FLALDLGGTNFRV L LV RV rn G KW 550
Cdd:pfam00349 3 EEL L KQFA LS DEK L K E IVD R FVE EME K GL A KE GSS S -- L KMLPTYV TSL P T GTEKG T FLALDLGGTNFRV C LV EL -- G GD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 551 G GVEMHNKI Y A IP Q E V M H GTG D ELFD H I VQ CIA D FL EYM G MK --- GVS LPLGFTFSFP C QQ N SLD E vtapswrallwall 627
Cdd:pfam00349 79 G KFSITQEK Y K IP E E L M T GTG E ELFD F I AD CIA E FL KEH G LE dfe EKE LPLGFTFSFP V QQ T SLD S -------------- 144
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515 628 tlnktsq SI L LK WTKGF KAS G CE G E DVV T LL K EA IH RR EE f DLD VVA V VNDTVGT M M TCGF 688
Cdd:pfam00349 145 ------- GT L IR WTKGF DIP G VV G K DVV Q LL Q EA LE RR GL - PVK VVA L VNDTVGT L M AGAY 197
Name
Accession
Description
Interval
E-value
PTZ00107
PTZ00107
hexokinase; Provisional
12-460
5.70e-118
hexokinase; Provisional
Pssm-ID: 240270 [Multi-domain]
Cd Length: 464
Bit Score: 368.23
E-value: 5.70e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 12 TELNHD Q VQKVDQYLYHMRL S D E T L L E ISKR F RK E MEK GL - GATT H PTA ------ AV KML PTF V RST P D G T E H G EFL A L D 84
Cdd:PTZ00107 1 EMRYIK Q RVRLASLVNQFTM S K E K L K E LVDY F LY E LVE GL e AHRR H RNL wipnec SF KML DSC V YNL P T G K E K G VYY A I D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 85 L GGTNFR VLW V KVTDN G lq K V E MENQIYAI P EDIMR G --------- SG T Q LFDHIA ECLANF M DKLQIKD --- K KL P L GF 152
Cdd:PTZ00107 81 F GGTNFR AVR V SLRGG G -- K M E RTQSKFSL P KSALL G ekglldkka TA T D LFDHIA KSIKKM M EENGDPE dln K PV P V GF 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPC H Q TKLDESF L VS WTKGF KSS ----- G VEG R DV VA L IRK A IQ R RG d FDIDI VAV V NDTVGT MMT C G Y DDH ---- N 223
Cdd:PTZ00107 159 TFSFPC T Q LSVNNAI L ID WTKGF ETG ratnd P VEG K DV GE L LND A FK R NN - VPANV VAV L NDTVGT LIS C A Y QKP kntp P 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 C EI G L I V GTGSNACY M E emrhi DM V E -- G DE G RM c INME W G A F gd D GS L N di R T EF D Q E I D MGSL N P G K Q L FEKMISG M Y 301
Cdd:PTZ00107 238 C QV G V I I GTGSNACY F E ----- PE V S ay G YA G TP - INME C G N F -- D SK L P -- I T PY D L E M D WYTP N R G R Q Q FEKMISG A Y 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 M GE LV R LIL V KMAKE ellfgg K LS P ELLNT G R FE TK D I S D I EGEK - DGIRKA R E V LMRL - GL D P T Q ED CVATHR IC QI V S 379
Cdd:PTZ00107 308 L GE IS R RLI V HLLQL ------ K AP P KMWQS G S FE SE D A S M I LNDQ s PDLQFS R Q V IKEA w DV D L T D ED LYTIRK IC EL V R 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 T R S A S L C AA TL AA VLQRIKENK G eerl RS T IGV DGSVY K K H P H F AKR L HKTVRRLV -- PGCD V R F LRSE DGSGKGAA MVT 457
Cdd:PTZ00107 382 G R A A Q L A AA FI AA PAKKTRTVQ G ---- KA T VAI DGSVY V K N P W F RRL L QEYINSIL gp DAGN V V F YLAD DGSGKGAA IIA 457
...
gi 530367515 458 A VA 460
Cdd:PTZ00107 458 A MV 460
Hexokinase_2
pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928
1.00e-108
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
Pssm-ID: 427467
Cd Length: 238
Bit Score: 335.23
E-value: 1.00e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 694 EV GLI V GTG S NA C Y M E EMR N VELV EG --- EE G R M CV N M EWGAFGDNG C L DDF RTE F D VAV D EL S L NPG K Q R FEKMISGMY 770
Cdd:pfam03727 1 RI GLI L GTG T NA A Y V E KVS N IPKL EG klp KS G E M II N T EWGAFGDNG L L PLP RTE Y D KEL D AE S P NPG F Q P FEKMISGMY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 771 LGE I VR NI L I D FTKR GLLF R G RIS E R LKT RGIFE T K FLS Q IESD - CLA L LQV R A IL Q - H LG L E S - T CD D SI IV KEV C TV V 847
Cdd:pfam03727 81 LGE L VR LV L L D LAEE GLLF G G QLP E K LKT PYSLD T S FLS A IESD p SED L ETT R E IL E e L LG I E T c T EE D RK IV RRI C EA V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 848 AR RAA Q L CG AG M AA VVDR I REN R gldalk VTVGVDG TL Y KLH P H F AKVMH E TVKD L AP --- KCD V SFLQS EDGSG K GAAL 924
Cdd:pfam03727 161 ST RAA R L VA AG I AA ILKK I GGG R ------ VTVGVDG SV Y EKY P G F RERLQ E ALRE L LG pel EDK V VLVLA EDGSG V GAAL 234
....
gi 530367515 925 I T AV 928
Cdd:pfam03727 235 I A AV 238
Hexokinase_2
pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
225-459
9.46e-105
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
Pssm-ID: 427467
Cd Length: 238
Bit Score: 324.83
E-value: 9.46e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 225 E IGLI V GTG S NA C Y M E EMRH I DMV EG D --- E G R M C IN M EWGAFGD D G S L NDI RTE F D Q E I D MG S L NPG K Q L FEKMISGMY 301
Cdd:pfam03727 1 R IGLI L GTG T NA A Y V E KVSN I PKL EG K lpk S G E M I IN T EWGAFGD N G L L PLP RTE Y D K E L D AE S P NPG F Q P FEKMISGMY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 M GELVRL I L VKM A K E E LLFGG K L SPE L LNTGRFE T KDI S D IE GEK - DGIRKA RE V L MR - LG L - DP T Q ED CVATH RIC QI V 378
Cdd:pfam03727 81 L GELVRL V L LDL A E E G LLFGG Q L PEK L KTPYSLD T SFL S A IE SDP s EDLETT RE I L EE l LG I e TC T E ED RKIVR RIC EA V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 379 STR S A S L C AA TL AA V L QR I KEN kgeerl R S T I GVDGSVY K K H P H F AK RL HKTV R R L VP --- GCD V RFLRS EDGSG K GAA M 455
Cdd:pfam03727 161 STR A A R L V AA GI AA I L KK I GGG ------ R V T V GVDGSVY E K Y P G F RE RL QEAL R E L LG pel EDK V VLVLA EDGSG V GAA L 234
....
gi 530367515 456 VT AV 459
Cdd:pfam03727 235 IA AV 238
COG5026
COG5026
Hexokinase [Carbohydrate transport and metabolism];
34-460
1.04e-104
Hexokinase [Carbohydrate transport and metabolism];
Pssm-ID: 227359 [Multi-domain]
Cd Length: 466
Bit Score: 333.22
E-value: 1.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 34 E T L L E IS K R F RK E M EKGL ga TTHPTAAVK M L PT F V RST P D G T E H G EF LA L DLGGTN F RV LW V KVTDN G lq KVEM E NQIYA 113
Cdd:COG5026 33 E D L R E VV K A F IE E L EKGL -- QPKSGDFLP M I PT W V APL P T G N E S G SV LA I DLGGTN L RV CL V VLGGD G -- TFDI E QSKSF 108
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 114 I P EDIMRG - S GTQ LF DH IA EC LA N F MDK -- LQIKDK KLP L GFTFS F P CH QT KLD E SF L VS WTKGF KSSG V E G R DVV A L IR 190
Cdd:COG5026 109 L P VECRDS e S RDE LF GF IA DR LA A F IKE qh PSGYGS KLP I GFTFS Y P LN QT SIN E GQ L IR WTKGF DIPE V I G T DVV R L LQ 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 K A IQR R G d FD I DI VAV V NDT V GT MMTCG Y DDHNCE IG L I V GTG S N A CY M E EMRH I DMVEG D ---- E G R M C IN M EWG A F gd 266
Cdd:COG5026 189 E A LSA R N - LP I RV VAV I NDT T GT LLASV Y TSSETI IG I I F GTG T N G CY C E PKGR I PKLPR D dlpe T G P M L IN C EWG S F -- 265
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 267 D GS L NDI - RT EF D QE ID MG S L NPG K Q L FEKM I SGMY M GEL V RLIL VKMAKEE L L F G G KLSPE L LNTGRFE T KDI S D I eg E 345
Cdd:COG5026 266 D NE L SVL p RT KY D VL ID QE S P NPG H Q I FEKM S SGMY L GEL L RLIL RNLYEQG L I F N G QDPEK L TDPFALS T SVL S R I -- E 343
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 346 K D GIRKA R EV L M ---- RLGLDP T Q E DCVATH R ICQIVST R S A S L C A ATL AA VLQRIKEN K geerl RSTI G V DGSV YKKH P 421
Cdd:COG5026 344 E D PFENL R NT L T tfln DFRAPT T K E ERKLIR R LVELIGR R A A R L A A VPI AA IVIKTGAY K ----- AYHV G A DGSV IERY P 418
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 530367515 422 H F AKR L HKTVRR L VPGCDVRF - LRS - EDGSG K GAA MVTAV A 460
Cdd:COG5026 419 G F RSM L REALKA L LGEEGEKI k IKP a EDGSG L GAA LCALL A 459
PTZ00107
PTZ00107
hexokinase; Provisional
462-929
3.23e-100
hexokinase; Provisional
Pssm-ID: 240270 [Multi-domain]
Cd Length: 464
Bit Score: 321.24
E-value: 3.23e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 462 R LAD Q HRARQKTLEHLQL S HDQ L L E VKRRMKV E MER GL - SKET H ASA ------ PV KML PTY V CAT P D G T EKG DFL A L D L G 534
Cdd:PTZ00107 3 R YIK Q RVRLASLVNQFTM S KEK L K E LVDYFLY E LVE GL e AHRR H RNL wipnec SF KML DSC V YNL P T G K EKG VYY A I D F G 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 535 GTNFR VLL V RV R N G kw G GV E MHNKIYAI P QEVM --------- HG T GDE LFDHI VQC I ADFL E YM G MK --- GVSL P L GFTF 602
Cdd:PTZ00107 83 GTNFR AVR V SL R G G -- G KM E RTQSKFSL P KSAL lgekglldk KA T ATD LFDHI AKS I KKMM E EN G DP edl NKPV P V GFTF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 603 SFPC Q Q N S LD evtapswrallwalltlnkts QS IL LK WTKGF KAS ----- GC EG E DV VT LL KE A I h R R EEFDLD VVAV V N 677
Cdd:PTZ00107 161 SFPC T Q L S VN --------------------- NA IL ID WTKGF ETG ratnd PV EG K DV GE LL ND A F - K R NNVPAN VVAV L N 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 678 DTVGT MMT C GFED ---- P H C E VG L I V GTGSNACY M E EM rnv ELVE G EE G RM c V NME W G A F gdng CLDDFR T EF D VAV D EL 753
Cdd:PTZ00107 219 DTVGT LIS C AYQK pknt P P C Q VG V I I GTGSNACY F E PE --- VSAY G YA G TP - I NME C G N F ---- DSKLPI T PY D LEM D WY 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 754 SL N P G K Q R FEKMISG M YLGEI V R NILI dftkrg L L FRGRISERLKTR G I FE TKFL S Q I ES D CLAL LQ V -- RA I LQHLGLE 831
Cdd:PTZ00107 291 TP N R G R Q Q FEKMISG A YLGEI S R RLIV ------ H L LQLKAPPKMWQS G S FE SEDA S M I LN D QSPD LQ F sr QV I KEAWDVD 364
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 832 S T CD D SIIVKEV C TV V AR RAAQL CG A GM AA VVDRI R ENR G ldal K V TV GV DG TL Y KLH P H F AKVMH E TVKD - L A P K - CD V 909
Cdd:PTZ00107 365 L T DE D LYTIRKI C EL V RG RAAQL AA A FI AA PAKKT R TVQ G ---- K A TV AI DG SV Y VKN P W F RRLLQ E YINS i L G P D a GN V 440
490 500
....*....|....*....|
gi 530367515 910 S F LQSE DGSGKGAA L I T A VA 929
Cdd:PTZ00107 441 V F YLAD DGSGKGAA I I A A MV 460
COG5026
COG5026
Hexokinase [Carbohydrate transport and metabolism];
468-929
1.56e-91
Hexokinase [Carbohydrate transport and metabolism];
Pssm-ID: 227359 [Multi-domain]
Cd Length: 466
Bit Score: 298.55
E-value: 1.56e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 468 R A RQKTL E HLQLSHDQ L L EV KRRMKV E M E R GL SKETHASA P vk M L PT Y V CAT P D G T E K G DF LA L DLGGTN F RV L LV RV rn 547
Cdd:COG5026 19 Q A VEELV E SFTVPTED L R EV VKAFIE E L E K GL QPKSGDFL P -- M I PT W V APL P T G N E S G SV LA I DLGGTN L RV C LV VL -- 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 548 G KW G GVEMHNKIYAI P Q E VMHG - TG DELF DH I VQCI A D F LE -- YMGMK G VS LP L GFTFS F P CQ Q N S LD E vtapswrallw 624
Cdd:COG5026 95 G GD G TFDIEQSKSFL P V E CRDS e SR DELF GF I ADRL A A F IK eq HPSGY G SK LP I GFTFS Y P LN Q T S IN E ----------- 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnktsq SI L LK WTKGF KASGCE G E DVV T LL K EA IHR R E e FDLD VVAV V NDT V GT MMTCGFEDPHCEV G L I V GTG S N 704
Cdd:COG5026 164 ---------- GQ L IR WTKGF DIPEVI G T DVV R LL Q EA LSA R N - LPIR VVAV I NDT T GT LLASVYTSSETII G I I F GTG T N 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 A CY M E EMRNVELVEG ---- E E G R M CV N M EWG A F g DN GCLDDF RT EF DV AV D EL S L NPG K Q R FEKM I SGMYLGE IV R N IL I 780
Cdd:COG5026 233 G CY C E PKGRIPKLPR ddlp E T G P M LI N C EWG S F - DN ELSVLP RT KY DV LI D QE S P NPG H Q I FEKM S SGMYLGE LL R L IL R 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 781 DFTKR GL L F R G RIS E R L KTRGIFE T KF LS Q IE S D - CLA L LQVRA - I L QHLGLES T CDDSIIVKEVCTVVA RRAA Q L CGAG 858
Cdd:COG5026 312 NLYEQ GL I F N G QDP E K L TDPFALS T SV LS R IE E D p FEN L RNTLT t F L NDFRAPT T KEERKLIRRLVELIG RRAA R L AAVP 391
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 859 M AA V V DRIRENRGLD alkvt VG V DG TLYKLH P H F AKVMH E TV K D L APKCDVSF - LQS - EDGSG K GAAL ITAV A 929
Cdd:COG5026 392 I AA I V IKTGAYKAYH ----- VG A DG SVIERY P G F RSMLR E AL K A L LGEEGEKI k IKP a EDGSG L GAAL CALL A 459
Hexokinase_1
pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688
4.45e-88
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.
Pssm-ID: 425627 [Multi-domain]
Cd Length: 197
Bit Score: 279.01
E-value: 4.45e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 471 QKT L EHLQ LS HDQ L L E VKR R MKV EME R GL S KE THA S ap V KMLPTYV CAT P D GTEKG D FLALDLGGTNFRV L LV RV rn G KW 550
Cdd:pfam00349 3 EEL L KQFA LS DEK L K E IVD R FVE EME K GL A KE GSS S -- L KMLPTYV TSL P T GTEKG T FLALDLGGTNFRV C LV EL -- G GD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 551 G GVEMHNKI Y A IP Q E V M H GTG D ELFD H I VQ CIA D FL EYM G MK --- GVS LPLGFTFSFP C QQ N SLD E vtapswrallwall 627
Cdd:pfam00349 79 G KFSITQEK Y K IP E E L M T GTG E ELFD F I AD CIA E FL KEH G LE dfe EKE LPLGFTFSFP V QQ T SLD S -------------- 144
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515 628 tlnktsq SI L LK WTKGF KAS G CE G E DVV T LL K EA IH RR EE f DLD VVA V VNDTVGT M M TCGF 688
Cdd:pfam00349 145 ------- GT L IR WTKGF DIP G VV G K DVV Q LL Q EA LE RR GL - PVK VVA L VNDTVGT L M AGAY 197
NBD_sugar-kinase_HSP70_actin
cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
81-262
8.83e-13
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.
Pssm-ID: 212657 [Multi-domain]
Cd Length: 185
Bit Score: 67.61
E-value: 8.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 81 L AL D L G G T NFRVLWVKVTDNG L QKVEMEN qiy AIPEDIMRGSGTQ L FDHIA E C L ANFMDK L qi K DKKLPL G F T FSFPCHQ 160
Cdd:cd00012 1 L GI D I G S T STKAGVADLDGEI L PEEIVPT --- PVGRPGAVTDLDE L EEALR E L L KEALRQ L -- K SEIDAV G I T EPGGVPK 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 161 TKLDESF L VSW tkgfkssgvegrdvva L IRKAIQRRG D FDIDI VAVVND T V GTMMTC G Y -- DDHNCEIGLIV GTG SN acy 238
Cdd:cd00012 76 ENREVII L PNL ---------------- L LIPLALALE D LGGVP VAVVND A V AAALAE G L fg KEEDTVLVVDL GTG TT --- 136
170 180
....*....|....*....|....
gi 530367515 239 meemr H I DM VE GDE G RMCINM E W G 262
Cdd:cd00012 137 ----- G I AI VE DGK G GVGAAG E L G 155
NBD_sugar-kinase_HSP70_actin
cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
529-720
2.69e-10
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.
Pssm-ID: 212657 [Multi-domain]
Cd Length: 185
Bit Score: 60.30
E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 529 L AL D L G G T NFRVLLVR vrngk WG G VEMHNK I YAI P QEVMHG -- TG DEL FDHIVQCIADF L EYMGMKG vs LPL G F T FSFPC 606
Cdd:cd00012 1 L GI D I G S T STKAGVAD ----- LD G EILPEE I VPT P VGRPGA vt DL DEL EEALRELLKEA L RQLKSEI -- DAV G I T EPGGV 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 607 QQNSLDEVTA P SW rallwalltlnktsqsillkwtkgfkasgcegedvvt LL KEAIHRR E EFDLDV VAVVND T V GTMMTC 686
Cdd:cd00012 74 PKENREVIIL P NL ------------------------------------- LL IPLALAL E DLGGVP VAVVND A V AAALAE 116
170 180 190
....*....|....*....|....*....|....*..
gi 530367515 687 G F -- EDPHCEVGLIV GTG S - NACYM E EMRNVELVE GE 720
Cdd:cd00012 117 G L fg KEEDTVLVVDL GTG T t GIAIV E DGKGGVGAA GE 153
Name
Accession
Description
Interval
E-value
PTZ00107
PTZ00107
hexokinase; Provisional
12-460
5.70e-118
hexokinase; Provisional
Pssm-ID: 240270 [Multi-domain]
Cd Length: 464
Bit Score: 368.23
E-value: 5.70e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 12 TELNHD Q VQKVDQYLYHMRL S D E T L L E ISKR F RK E MEK GL - GATT H PTA ------ AV KML PTF V RST P D G T E H G EFL A L D 84
Cdd:PTZ00107 1 EMRYIK Q RVRLASLVNQFTM S K E K L K E LVDY F LY E LVE GL e AHRR H RNL wipnec SF KML DSC V YNL P T G K E K G VYY A I D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 85 L GGTNFR VLW V KVTDN G lq K V E MENQIYAI P EDIMR G --------- SG T Q LFDHIA ECLANF M DKLQIKD --- K KL P L GF 152
Cdd:PTZ00107 81 F GGTNFR AVR V SLRGG G -- K M E RTQSKFSL P KSALL G ekglldkka TA T D LFDHIA KSIKKM M EENGDPE dln K PV P V GF 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPC H Q TKLDESF L VS WTKGF KSS ----- G VEG R DV VA L IRK A IQ R RG d FDIDI VAV V NDTVGT MMT C G Y DDH ---- N 223
Cdd:PTZ00107 159 TFSFPC T Q LSVNNAI L ID WTKGF ETG ratnd P VEG K DV GE L LND A FK R NN - VPANV VAV L NDTVGT LIS C A Y QKP kntp P 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 C EI G L I V GTGSNACY M E emrhi DM V E -- G DE G RM c INME W G A F gd D GS L N di R T EF D Q E I D MGSL N P G K Q L FEKMISG M Y 301
Cdd:PTZ00107 238 C QV G V I I GTGSNACY F E ----- PE V S ay G YA G TP - INME C G N F -- D SK L P -- I T PY D L E M D WYTP N R G R Q Q FEKMISG A Y 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 M GE LV R LIL V KMAKE ellfgg K LS P ELLNT G R FE TK D I S D I EGEK - DGIRKA R E V LMRL - GL D P T Q ED CVATHR IC QI V S 379
Cdd:PTZ00107 308 L GE IS R RLI V HLLQL ------ K AP P KMWQS G S FE SE D A S M I LNDQ s PDLQFS R Q V IKEA w DV D L T D ED LYTIRK IC EL V R 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 T R S A S L C AA TL AA VLQRIKENK G eerl RS T IGV DGSVY K K H P H F AKR L HKTVRRLV -- PGCD V R F LRSE DGSGKGAA MVT 457
Cdd:PTZ00107 382 G R A A Q L A AA FI AA PAKKTRTVQ G ---- KA T VAI DGSVY V K N P W F RRL L QEYINSIL gp DAGN V V F YLAD DGSGKGAA IIA 457
...
gi 530367515 458 A VA 460
Cdd:PTZ00107 458 A MV 460
Hexokinase_2
pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928
1.00e-108
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
Pssm-ID: 427467
Cd Length: 238
Bit Score: 335.23
E-value: 1.00e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 694 EV GLI V GTG S NA C Y M E EMR N VELV EG --- EE G R M CV N M EWGAFGDNG C L DDF RTE F D VAV D EL S L NPG K Q R FEKMISGMY 770
Cdd:pfam03727 1 RI GLI L GTG T NA A Y V E KVS N IPKL EG klp KS G E M II N T EWGAFGDNG L L PLP RTE Y D KEL D AE S P NPG F Q P FEKMISGMY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 771 LGE I VR NI L I D FTKR GLLF R G RIS E R LKT RGIFE T K FLS Q IESD - CLA L LQV R A IL Q - H LG L E S - T CD D SI IV KEV C TV V 847
Cdd:pfam03727 81 LGE L VR LV L L D LAEE GLLF G G QLP E K LKT PYSLD T S FLS A IESD p SED L ETT R E IL E e L LG I E T c T EE D RK IV RRI C EA V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 848 AR RAA Q L CG AG M AA VVDR I REN R gldalk VTVGVDG TL Y KLH P H F AKVMH E TVKD L AP --- KCD V SFLQS EDGSG K GAAL 924
Cdd:pfam03727 161 ST RAA R L VA AG I AA ILKK I GGG R ------ VTVGVDG SV Y EKY P G F RERLQ E ALRE L LG pel EDK V VLVLA EDGSG V GAAL 234
....
gi 530367515 925 I T AV 928
Cdd:pfam03727 235 I A AV 238
Hexokinase_2
pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
225-459
9.46e-105
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.
Pssm-ID: 427467
Cd Length: 238
Bit Score: 324.83
E-value: 9.46e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 225 E IGLI V GTG S NA C Y M E EMRH I DMV EG D --- E G R M C IN M EWGAFGD D G S L NDI RTE F D Q E I D MG S L NPG K Q L FEKMISGMY 301
Cdd:pfam03727 1 R IGLI L GTG T NA A Y V E KVSN I PKL EG K lpk S G E M I IN T EWGAFGD N G L L PLP RTE Y D K E L D AE S P NPG F Q P FEKMISGMY 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 M GELVRL I L VKM A K E E LLFGG K L SPE L LNTGRFE T KDI S D IE GEK - DGIRKA RE V L MR - LG L - DP T Q ED CVATH RIC QI V 378
Cdd:pfam03727 81 L GELVRL V L LDL A E E G LLFGG Q L PEK L KTPYSLD T SFL S A IE SDP s EDLETT RE I L EE l LG I e TC T E ED RKIVR RIC EA V 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 379 STR S A S L C AA TL AA V L QR I KEN kgeerl R S T I GVDGSVY K K H P H F AK RL HKTV R R L VP --- GCD V RFLRS EDGSG K GAA M 455
Cdd:pfam03727 161 STR A A R L V AA GI AA I L KK I GGG ------ R V T V GVDGSVY E K Y P G F RE RL QEAL R E L LG pel EDK V VLVLA EDGSG V GAA L 234
....
gi 530367515 456 VT AV 459
Cdd:pfam03727 235 IA AV 238
COG5026
COG5026
Hexokinase [Carbohydrate transport and metabolism];
34-460
1.04e-104
Hexokinase [Carbohydrate transport and metabolism];
Pssm-ID: 227359 [Multi-domain]
Cd Length: 466
Bit Score: 333.22
E-value: 1.04e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 34 E T L L E IS K R F RK E M EKGL ga TTHPTAAVK M L PT F V RST P D G T E H G EF LA L DLGGTN F RV LW V KVTDN G lq KVEM E NQIYA 113
Cdd:COG5026 33 E D L R E VV K A F IE E L EKGL -- QPKSGDFLP M I PT W V APL P T G N E S G SV LA I DLGGTN L RV CL V VLGGD G -- TFDI E QSKSF 108
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 114 I P EDIMRG - S GTQ LF DH IA EC LA N F MDK -- LQIKDK KLP L GFTFS F P CH QT KLD E SF L VS WTKGF KSSG V E G R DVV A L IR 190
Cdd:COG5026 109 L P VECRDS e S RDE LF GF IA DR LA A F IKE qh PSGYGS KLP I GFTFS Y P LN QT SIN E GQ L IR WTKGF DIPE V I G T DVV R L LQ 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 K A IQR R G d FD I DI VAV V NDT V GT MMTCG Y DDHNCE IG L I V GTG S N A CY M E EMRH I DMVEG D ---- E G R M C IN M EWG A F gd 266
Cdd:COG5026 189 E A LSA R N - LP I RV VAV I NDT T GT LLASV Y TSSETI IG I I F GTG T N G CY C E PKGR I PKLPR D dlpe T G P M L IN C EWG S F -- 265
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 267 D GS L NDI - RT EF D QE ID MG S L NPG K Q L FEKM I SGMY M GEL V RLIL VKMAKEE L L F G G KLSPE L LNTGRFE T KDI S D I eg E 345
Cdd:COG5026 266 D NE L SVL p RT KY D VL ID QE S P NPG H Q I FEKM S SGMY L GEL L RLIL RNLYEQG L I F N G QDPEK L TDPFALS T SVL S R I -- E 343
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 346 K D GIRKA R EV L M ---- RLGLDP T Q E DCVATH R ICQIVST R S A S L C A ATL AA VLQRIKEN K geerl RSTI G V DGSV YKKH P 421
Cdd:COG5026 344 E D PFENL R NT L T tfln DFRAPT T K E ERKLIR R LVELIGR R A A R L A A VPI AA IVIKTGAY K ----- AYHV G A DGSV IERY P 418
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 530367515 422 H F AKR L HKTVRR L VPGCDVRF - LRS - EDGSG K GAA MVTAV A 460
Cdd:COG5026 419 G F RSM L REALKA L LGEEGEKI k IKP a EDGSG L GAA LCALL A 459
PTZ00107
PTZ00107
hexokinase; Provisional
462-929
3.23e-100
hexokinase; Provisional
Pssm-ID: 240270 [Multi-domain]
Cd Length: 464
Bit Score: 321.24
E-value: 3.23e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 462 R LAD Q HRARQKTLEHLQL S HDQ L L E VKRRMKV E MER GL - SKET H ASA ------ PV KML PTY V CAT P D G T EKG DFL A L D L G 534
Cdd:PTZ00107 3 R YIK Q RVRLASLVNQFTM S KEK L K E LVDYFLY E LVE GL e AHRR H RNL wipnec SF KML DSC V YNL P T G K EKG VYY A I D F G 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 535 GTNFR VLL V RV R N G kw G GV E MHNKIYAI P QEVM --------- HG T GDE LFDHI VQC I ADFL E YM G MK --- GVSL P L GFTF 602
Cdd:PTZ00107 83 GTNFR AVR V SL R G G -- G KM E RTQSKFSL P KSAL lgekglldk KA T ATD LFDHI AKS I KKMM E EN G DP edl NKPV P V GFTF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 603 SFPC Q Q N S LD evtapswrallwalltlnkts QS IL LK WTKGF KAS ----- GC EG E DV VT LL KE A I h R R EEFDLD VVAV V N 677
Cdd:PTZ00107 161 SFPC T Q L S VN --------------------- NA IL ID WTKGF ETG ratnd PV EG K DV GE LL ND A F - K R NNVPAN VVAV L N 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 678 DTVGT MMT C GFED ---- P H C E VG L I V GTGSNACY M E EM rnv ELVE G EE G RM c V NME W G A F gdng CLDDFR T EF D VAV D EL 753
Cdd:PTZ00107 219 DTVGT LIS C AYQK pknt P P C Q VG V I I GTGSNACY F E PE --- VSAY G YA G TP - I NME C G N F ---- DSKLPI T PY D LEM D WY 290
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 754 SL N P G K Q R FEKMISG M YLGEI V R NILI dftkrg L L FRGRISERLKTR G I FE TKFL S Q I ES D CLAL LQ V -- RA I LQHLGLE 831
Cdd:PTZ00107 291 TP N R G R Q Q FEKMISG A YLGEI S R RLIV ------ H L LQLKAPPKMWQS G S FE SEDA S M I LN D QSPD LQ F sr QV I KEAWDVD 364
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 832 S T CD D SIIVKEV C TV V AR RAAQL CG A GM AA VVDRI R ENR G ldal K V TV GV DG TL Y KLH P H F AKVMH E TVKD - L A P K - CD V 909
Cdd:PTZ00107 365 L T DE D LYTIRKI C EL V RG RAAQL AA A FI AA PAKKT R TVQ G ---- K A TV AI DG SV Y VKN P W F RRLLQ E YINS i L G P D a GN V 440
490 500
....*....|....*....|
gi 530367515 910 S F LQSE DGSGKGAA L I T A VA 929
Cdd:PTZ00107 441 V F YLAD DGSGKGAA I I A A MV 460
Hexokinase_1
pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
21-219
4.22e-95
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.
Pssm-ID: 425627 [Multi-domain]
Cd Length: 197
Bit Score: 297.88
E-value: 4.22e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 21 KVDQY L YHMR LSDE T L L EI SK RF RK EMEKGL GA tt HPTAAV KMLPT F V R S T P D GTE H G E FLALDLGGTNFRV LW V KVTDN 100
Cdd:pfam00349 1 ALEEL L KQFA LSDE K L K EI VD RF VE EMEKGL AK -- EGSSSL KMLPT Y V T S L P T GTE K G T FLALDLGGTNFRV CL V ELGGD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 101 G lq K VEMENQI Y A IPE DI M R G S G TQ LFD H IA E C L A N F MDKLQIK D --- K K LPLGFTFSFP CH QT K LD ESF L VS WTKGF KS 177
Cdd:pfam00349 79 G -- K FSITQEK Y K IPE EL M T G T G EE LFD F IA D C I A E F LKEHGLE D fee K E LPLGFTFSFP VQ QT S LD SGT L IR WTKGF DI 156
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 530367515 178 S GV E G R DVV A L IRK A IQ RRG D f DIDI VA V VNDTVGT M M TCG Y 219
Cdd:pfam00349 157 P GV V G K DVV Q L LQE A LE RRG L - PVKV VA L VNDTVGT L M AGA Y 197
PLN02914
PLN02914
hexokinase
474-927
2.80e-92
hexokinase
Pssm-ID: 178502 [Multi-domain]
Cd Length: 490
Bit Score: 301.03
E-value: 2.80e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 474 L EH LQ LSHDQL L E V K R R ---- M KVE M ER GL SKE th ASAPV KM LPT YV CAT P D G T EKG D F L ALDLGGTNFRVL L V RVRNGK 549
Cdd:PLN02914 41 L TK LQ KDCATP L P V L R H vada M AAD M RA GL AVD -- GGGDL KM ILS YV DSL P S G N EKG L F Y ALDLGGTNFRVL R V QLGGKD 118
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 550 WGGVEMHNKIYA IPQE V M H GT GD ELFD H I VQCI A D F LEYM G M K ----- G VSLPL GFTFSFP CQ Q N S L D evtapswrallw 624
Cdd:PLN02914 119 ERVIATEFEQVS IPQE L M F GT SE ELFD F I ASGL A N F VAKE G G K fhlpe G RKREI GFTFSFP VK Q T S I D ------------ 186
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnkts QS IL L KWTKGF KA SG CE G E DVV TL L K EA IH R r EEF D LD V V A V VNDTVGT MMTCGFE D PHCE V GL I V GTG S N 704
Cdd:PLN02914 187 --------- SG IL M KWTKGF AV SG TA G K DVV AC L N EA ME R - QGL D MR V S A L VNDTVGT LAGARYW D DDVM V AV I L GTG T N 256
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 ACY M E EMRNVELVE G --- EE GR MCV N M EWGAF G D NGC L ddfr TEFD VAV D EL S L NPG K Q R FEK M ISGMYLGEIVR NI L ID 781
Cdd:PLN02914 257 ACY V E RTDAIPKLQ G qks SS GR TII N T EWGAF S D GLP L ---- TEFD REM D AA S I NPG E Q I FEK T ISGMYLGEIVR RV L LK 332
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 782 FTKRGL LF RGRIS E R L K T RGIFE T KF L SQIES D CLAL LQ - V RA IL QH - LG L E STCDDSII V K EVC TVVAR R AAQ L C GAG M 859
Cdd:PLN02914 333 MAETSD LF GHFVP E K L S T PFALR T PH L CAMQQ D NSDD LQ a V GS IL YD v LG V E ASLSARRR V V EVC DTIVK R GGR L A GAG I 412
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 860 AAVVDRIR E N - R G LDAL K V T - V GV DG T LY KLH P HFAKV M HET V KD - L APKC -- DVSFLQSE DGSG K GAAL IT A 927
Cdd:PLN02914 413 VGILEKME E D s K G MIFG K R T v V AM DG G LY EKY P QYRRY M QDA V TE l L GLEL sk NIAIEHTK DGSG I GAAL LA A 485
COG5026
COG5026
Hexokinase [Carbohydrate transport and metabolism];
468-929
1.56e-91
Hexokinase [Carbohydrate transport and metabolism];
Pssm-ID: 227359 [Multi-domain]
Cd Length: 466
Bit Score: 298.55
E-value: 1.56e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 468 R A RQKTL E HLQLSHDQ L L EV KRRMKV E M E R GL SKETHASA P vk M L PT Y V CAT P D G T E K G DF LA L DLGGTN F RV L LV RV rn 547
Cdd:COG5026 19 Q A VEELV E SFTVPTED L R EV VKAFIE E L E K GL QPKSGDFL P -- M I PT W V APL P T G N E S G SV LA I DLGGTN L RV C LV VL -- 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 548 G KW G GVEMHNKIYAI P Q E VMHG - TG DELF DH I VQCI A D F LE -- YMGMK G VS LP L GFTFS F P CQ Q N S LD E vtapswrallw 624
Cdd:COG5026 95 G GD G TFDIEQSKSFL P V E CRDS e SR DELF GF I ADRL A A F IK eq HPSGY G SK LP I GFTFS Y P LN Q T S IN E ----------- 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnktsq SI L LK WTKGF KASGCE G E DVV T LL K EA IHR R E e FDLD VVAV V NDT V GT MMTCGFEDPHCEV G L I V GTG S N 704
Cdd:COG5026 164 ---------- GQ L IR WTKGF DIPEVI G T DVV R LL Q EA LSA R N - LPIR VVAV I NDT T GT LLASVYTSSETII G I I F GTG T N 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 A CY M E EMRNVELVEG ---- E E G R M CV N M EWG A F g DN GCLDDF RT EF DV AV D EL S L NPG K Q R FEKM I SGMYLGE IV R N IL I 780
Cdd:COG5026 233 G CY C E PKGRIPKLPR ddlp E T G P M LI N C EWG S F - DN ELSVLP RT KY DV LI D QE S P NPG H Q I FEKM S SGMYLGE LL R L IL R 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 781 DFTKR GL L F R G RIS E R L KTRGIFE T KF LS Q IE S D - CLA L LQVRA - I L QHLGLES T CDDSIIVKEVCTVVA RRAA Q L CGAG 858
Cdd:COG5026 312 NLYEQ GL I F N G QDP E K L TDPFALS T SV LS R IE E D p FEN L RNTLT t F L NDFRAPT T KEERKLIRRLVELIG RRAA R L AAVP 391
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 859 M AA V V DRIRENRGLD alkvt VG V DG TLYKLH P H F AKVMH E TV K D L APKCDVSF - LQS - EDGSG K GAAL ITAV A 929
Cdd:COG5026 392 I AA I V IKTGAYKAYH ----- VG A DG SVIERY P G F RSMLR E AL K A L LGEEGEKI k IKP a EDGSG L GAAL CALL A 459
PLN02914
PLN02914
hexokinase
61-458
7.62e-89
hexokinase
Pssm-ID: 178502 [Multi-domain]
Cd Length: 490
Bit Score: 292.17
E-value: 7.62e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 61 V KM LPTF V R S T P D G T E H G E F L ALDLGGTNFRVL W V KVTDNGLQKVEM E NQIYA IP EDI M R G SGTQ LFD H IA EC LANF MD K 140
Cdd:PLN02914 78 L KM ILSY V D S L P S G N E K G L F Y ALDLGGTNFRVL R V QLGGKDERVIAT E FEQVS IP QEL M F G TSEE LFD F IA SG LANF VA K 157
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 141 LQI K ----- DK K LPL GFTFSFP CH QT KL D ESF L VS WTKGF KS SG VE G R DVVA LIRK A IQ R R G d F D IDIV A V VNDTVGT MM 215
Cdd:PLN02914 158 EGG K fhlpe GR K REI GFTFSFP VK QT SI D SGI L MK WTKGF AV SG TA G K DVVA CLNE A ME R Q G - L D MRVS A L VNDTVGT LA 236
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 216 TCG Y D D HNCEIGL I V GTG S NACY M E EMRH I DMVE G DE --- GR MC IN M EWGAF G D DGS L ndir TEFD Q E I D MG S L NPG K Q L 292
Cdd:PLN02914 237 GAR Y W D DDVMVAV I L GTG T NACY V E RTDA I PKLQ G QK sss GR TI IN T EWGAF S D GLP L ---- TEFD R E M D AA S I NPG E Q I 312
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 293 FEK M ISGMY M GE L VR LI L V KMA KEEL LFG GKLSPE L LNTGRFE T KDISDIEGE - K D GIRKAREV L MR - LG LDPTQEDCVA 370
Cdd:PLN02914 313 FEK T ISGMY L GE I VR RV L L KMA ETSD LFG HFVPEK L STPFALR T PHLCAMQQD n S D DLQAVGSI L YD v LG VEASLSARRR 392
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 371 THRI C QIVST R SAS L CA A TLAAV L QRIK E NK ge ERL ---- R STIGV DG SV Y K K H P HFAKRLHKT V RR L VP --- GCDVRFL 443
Cdd:PLN02914 393 VVEV C DTIVK R GGR L AG A GIVGI L EKME E DS -- KGM ifgk R TVVAM DG GL Y E K Y P QYRRYMQDA V TE L LG lel SKNIAIE 470
410
....*....|....*
gi 530367515 444 RSE DGSG K GAA MVT A 458
Cdd:PLN02914 471 HTK DGSG I GAA LLA A 485
Hexokinase_1
pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688
4.45e-88
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.
Pssm-ID: 425627 [Multi-domain]
Cd Length: 197
Bit Score: 279.01
E-value: 4.45e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 471 QKT L EHLQ LS HDQ L L E VKR R MKV EME R GL S KE THA S ap V KMLPTYV CAT P D GTEKG D FLALDLGGTNFRV L LV RV rn G KW 550
Cdd:pfam00349 3 EEL L KQFA LS DEK L K E IVD R FVE EME K GL A KE GSS S -- L KMLPTYV TSL P T GTEKG T FLALDLGGTNFRV C LV EL -- G GD 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 551 G GVEMHNKI Y A IP Q E V M H GTG D ELFD H I VQ CIA D FL EYM G MK --- GVS LPLGFTFSFP C QQ N SLD E vtapswrallwall 627
Cdd:pfam00349 79 G KFSITQEK Y K IP E E L M T GTG E ELFD F I AD CIA E FL KEH G LE dfe EKE LPLGFTFSFP V QQ T SLD S -------------- 144
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515 628 tlnktsq SI L LK WTKGF KAS G CE G E DVV T LL K EA IH RR EE f DLD VVA V VNDTVGT M M TCGF 688
Cdd:pfam00349 145 ------- GT L IR WTKGF DIP G VV G K DVV Q LL Q EA LE RR GL - PVK VVA L VNDTVGT L M AGAY 197
PLN02405
PLN02405
hexokinase
46-458
2.00e-79
hexokinase
Pssm-ID: 215226 [Multi-domain]
Cd Length: 497
Bit Score: 266.70
E-value: 2.00e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 46 EM EK GL G at THPTAAV KML PTF V RST P D G T E H G E F L ALDLGGTNFRVL W V KV -- T D NGLQ K V E M E NQ iy A IP EDI M R GS G 123
Cdd:PLN02405 65 EM HA GL A -- SEGGSKL KML ISY V DNL P S G D E K G L F Y ALDLGGTNFRVL R V LL gg K D GRVV K Q E F E EV -- S IP PHL M T GS S 140
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 124 TQ LFD H IA EC LA N F MDK l QIK D KK LP ------ LGFTFSFP CH QT KLDESF L VS WTKGF KSSGVE G R DVV ALIR KA IQ R R G 197
Cdd:PLN02405 141 DA LFD F IA AA LA K F VAT - EGE D FH LP pgrqre LGFTFSFP VK QT SISSGT L IK WTKGF SIDDAV G Q DVV GELT KA ME R V G 219
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 198 d F D IDIV A V VNDT V GT MMTCG Y DDHNCEIGL I V GTG S NA C Y M E EMRH I DMVE G D --- E G R M C INMEWG A F G ddg S LNDIR 274
Cdd:PLN02405 220 - L D MRVS A L VNDT I GT LAGGR Y YNPDVVAAV I L GTG T NA A Y V E RAQA I PKWH G L lpk S G E M V INMEWG N F R --- S SHLPL 295
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 275 TE F D QEI D MG SLNPG K Q L FEK M ISGMY M GE LV R LI L V KMA K E ELL FG GKLS P E L LNTGRFE T K D I S -------------- 340
Cdd:PLN02405 296 TE Y D HAL D VE SLNPG E Q I FEK I ISGMY L GE IL R RV L L KMA E E AAF FG DTVP P K L KIPFILR T P D M S amhhdtspdlkvvg 375
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 341 ---- DI EGEKDGIR K A R E V LMR L gldptqedcvathri C Q IV S TR S A S L C AA TLAAV L QRIKEN -- K GE E RLR S T I GV DG 414
Cdd:PLN02405 376 sklk DI LEIPNTSL K M R K V VVE L --------------- C N IV A TR G A R L S AA GIYGI L KKLGRD tv K DG E KQK S V I AM DG 440
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 530367515 415 SVYKKHPH F A K RLHK T VRR L V p G CD V R ---- FLR S E DGSG K GAA MVT A 458
Cdd:PLN02405 441 GLFEHYTE F S K CMES T LKE L L - G EE V S esie VEH S N DGSG I GAA LLA A 487
PLN02362
PLN02362
hexokinase
483-927
1.17e-75
hexokinase
Pssm-ID: 215206 [Multi-domain]
Cd Length: 509
Bit Score: 257.12
E-value: 1.17e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 Q L LE V KRR M K VEM ER GL SK E th ASAPV KML P T Y V CAT P D G T E K G DFL ALDLGGTNFRVL L V RV r N G KWGGVEMHN - KIYA 561
Cdd:PLN02362 54 R L RQ V VDA M A VEM HA GL AS E -- GGSKL KML L T F V DDL P T G S E I G TYY ALDLGGTNFRVL R V QL - G G QRSSILSQD v ERHP 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 562 IPQ EV M HG T GDE LFD H I VQCIAD F L E YMG ----- MKGVSLP LGFTFSFP CQ Q N S L devtapswrallwalltlnkt S QS I 636
Cdd:PLN02362 131 IPQ HL M NS T SEV LFD F I ASSLKQ F V E KEE ngsef SQVRRRE LGFTFSFP VK Q T S I --------------------- S SG I 189
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 637 L L KWTKGF KA S GCE G E DV VTL L KE A IH RR E e F D LD V V A V VNDTVGT MMTCGFE DP HCEVGL I V GTG S NACY M E EMRNVEL 716
Cdd:PLN02362 190 L I KWTKGF AI S DMV G K DV AEC L QG A LN RR G - L D MR V A A L VNDTVGT LALGHYH DP DTVAAV I I GTG T NACY L E RTDAIIK 268
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 717 VE G --- EE G R M C VNMEWG A F GDNGCL ddf RT EF D VAV D EL S L NP GK Q R FEKMISGMYLG E IVR NILIDFTKRGLL F r G RI 793
Cdd:PLN02362 269 CQ G llt TS G S M V VNMEWG N F WSSHLP --- RT SY D IDL D AE S P NP ND Q G FEKMISGMYLG D IVR RVILRMSQESDI F - G PV 344
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 794 S E RL K T RGIFE T KFLSQI - E S D CLA L LQ V RA IL QH - LG L - E STCDDSII V KEV C T VV A RRAA Q L CG AG MAAVVDR I - R EN 869
Cdd:PLN02362 345 S S RL S T PFVLR T PSVAAM h E D D SPE L QE V AR IL KE t LG I s E VPLKVRKL V VKI C D VV T RRAA R L AA AG IVGILKK I g R DG 424
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 870 R G LDAL ----------- KVT V G V D G T LY KLHPH F AKVM HE TVKDLAPK c DV S ---- FLQS EDGSG K G A AL IT A 927
Cdd:PLN02362 425 S G GITS grsrsdiqimr RTV V A V E G G LY TNYTM F REYL HE ALNEILGE - DV A qhvi LKAT EDGSG I G S AL LA A 496
PLN02405
PLN02405
hexokinase
483-927
4.77e-75
hexokinase
Pssm-ID: 215226 [Multi-domain]
Cd Length: 497
Bit Score: 254.76
E-value: 4.77e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 Q L LE V KRR M K VEM ER GL SK E th ASAPV KML PT YV CAT P D G T EKG D F L ALDLGGTNFRVL L V RV r N GK W G G - V EMHNKIYA 561
Cdd:PLN02405 54 K L RQ V ADA M T VEM HA GL AS E -- GGSKL KML IS YV DNL P S G D EKG L F Y ALDLGGTNFRVL R V LL - G GK D G R v V KQEFEEVS 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 562 IP QEV M H G TG D E LFD H I VQCI A D F LEYM G m KGVS LP ------ LGFTFSFP CQ Q N S L devtapswrallwalltlnkt S QS 635
Cdd:PLN02405 131 IP PHL M T G SS D A LFD F I AAAL A K F VATE G - EDFH LP pgrqre LGFTFSFP VK Q T S I --------------------- S SG 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 636 I L L KWTKGF KASGCE G E DVV TL L KE A I h R R EEF D LD V V A V VNDT V GT MMTCGFED P HCEVGL I V GTG S NA C Y M E EMRNVE 715
Cdd:PLN02405 189 T L I KWTKGF SIDDAV G Q DVV GE L TK A M - E R VGL D MR V S A L VNDT I GT LAGGRYYN P DVVAAV I L GTG T NA A Y V E RAQAIP 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 716 LVE G --- EE G R M CV NMEWG afgdngcld D FR ------ TE F D V A V D EL SLNPG K Q R FEK M ISGMYLGEI V R NI L IDFTKRG 786
Cdd:PLN02405 268 KWH G llp KS G E M VI NMEWG --------- N FR sshlpl TE Y D H A L D VE SLNPG E Q I FEK I ISGMYLGEI L R RV L LKMAEEA 338
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 787 LL F RGRISER LK TRG I FE T KFL S QIES D CLAL L Q V RAILQHLG LE --- STCDDSII V K E V C TV VA R R A A Q L CG AG MAAVV 863
Cdd:PLN02405 339 AF F GDTVPPK LK IPF I LR T PDM S AMHH D TSPD L K V VGSKLKDI LE ipn TSLKMRKV V V E L C NI VA T R G A R L SA AG IYGIL 418
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530367515 864 DRIREN -- RGLDAL K VTVGV DG T L YKLHPH F A K V M HE T V K D L APK --- CDVSFLQ S E DGSG K GAAL IT A 927
Cdd:PLN02405 419 KKLGRD tv KDGEKQ K SVIAM DG G L FEHYTE F S K C M ES T L K E L LGE evs ESIEVEH S N DGSG I GAAL LA A 487
PLN02362
PLN02362
hexokinase
46-458
3.24e-70
hexokinase
Pssm-ID: 215206 [Multi-domain]
Cd Length: 509
Bit Score: 242.09
E-value: 3.24e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 46 EM EK GL ga TTHPTAAV KML P TFV RST P D G T E H G EFL ALDLGGTNFRVL W V KVTD -- NGLQKVEM E NQ iy A IP EDI M RGSG 123
Cdd:PLN02362 65 EM HA GL -- ASEGGSKL KML L TFV DDL P T G S E I G TYY ALDLGGTNFRVL R V QLGG qr SSILSQDV E RH -- P IP QHL M NSTS 140
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 124 TQ LFD H IA EC L AN F MD K LQ ----- IKDKKLP LGFTFSFP CH QT KLDESF L VS WTKGF KS S GVE G R DV VALIRK A IQ RRG d 198
Cdd:PLN02362 141 EV LFD F IA SS L KQ F VE K EE ngsef SQVRRRE LGFTFSFP VK QT SISSGI L IK WTKGF AI S DMV G K DV AECLQG A LN RRG - 219
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 199 F D IDIV A V VNDTVGT MMTCG Y D D HNCEIGL I V GTG S NACY M E EMRH I DMVE G --- DE G R M CI NMEWG A F G ddg S LNDI RT 275
Cdd:PLN02362 220 L D MRVA A L VNDTVGT LALGH Y H D PDTVAAV I I GTG T NACY L E RTDA I IKCQ G llt TS G S M VV NMEWG N F W --- S SHLP RT 296
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 276 EF D QEI D MG S L NP GK Q L FEKMISGMY M G EL VR LILVK M AK E ELL FG --- GK LS - P EL L N T GRF --------- E TKDISD I 342
Cdd:PLN02362 297 SY D IDL D AE S P NP ND Q G FEKMISGMY L G DI VR RVILR M SQ E SDI FG pvs SR LS t P FV L R T PSV aamheddsp E LQEVAR I 376
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 343 EG E KD GI R ---- K A R EVLM rlgldptqedcvath R IC QI V ST R S A S L C AA TLAAV L QR I KE ---------- NKGEERL -- 406
Cdd:PLN02362 377 LK E TL GI S evpl K V R KLVV --------------- K IC DV V TR R A A R L A AA GIVGI L KK I GR dgsggitsgr SRSDIQI mr 441
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 530367515 407 R STIG V D G SV Y KKHPH F AKR LH KTVRRLV p G C DV R ---- FLRS EDGSG K G A A MVT A 458
Cdd:PLN02362 442 R TVVA V E G GL Y TNYTM F REY LH EALNEIL - G E DV A qhvi LKAT EDGSG I G S A LLA A 496
PLN02596
PLN02596
hexokinase-like
36-458
3.43e-52
hexokinase-like
Pssm-ID: 178206
Cd Length: 490
Bit Score: 190.86
E-value: 3.43e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 36 L L E ISKRFRKE M EKG L ga T THP T AAVK ML PTF V R S T P D G T E H G EFLA L D L G G T NF RV L WVKVTDNGLQKVEMENQIYA IP 115
Cdd:PLN02596 56 L W E VADALVSD M TAS L -- T AEE T TTLN ML VSY V A S L P S G D E K G LYYG L N L R G S NF LL L RARLGGKNEPISDLYREEIS IP 133
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 116 EDIMR G SGTQ LFD H IA EC LA N F M ----- D KLQIKDKKLP LGFT F S F P CH Q TKLDESFLVS W t K G F KSSGVE G RDV V AL I R 190
Cdd:PLN02596 134 SNVLN G TSQE LFD Y IA LE LA K F V aehpg D EADTPERVKK LGFT V S Y P VD Q AAASSGSAIK W - K S F SADDTV G KAL V ND I N 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 K A IQRR G d FD I DIV A V V N DT V G TMMTCG Y DDHNCEIGLIV G T G S NA C Y M E EMRH I DMVEG --- DEGRMC I NM EWG A F G dd 267
Cdd:PLN02596 213 R A LEKH G - LK I RVF A L V D DT I G NLAGGR Y YNKDTVAAVTL G M G T NA A Y V E PAQA I PKWQS psp ESQEIV I ST EWG N F N -- 289
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 268 g S LNDIR TEFD QEI D MG S L NPG KQL FEK MI SGMY M GE L VR LI L V KMA K E EL LFG GK L S P E L LNTGRFETK D IS ---- D IE 343
Cdd:PLN02596 290 - S CHLPI TEFD ASL D AE S S NPG SRI FEK LT SGMY L GE I VR RV L L KMA E E TA LFG DT L P P K L TTPYLLRSP D MA amhq D TS 368
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 344 GEKDGI - R K AR E VLMRLGLD P TQEDC VA th RI C Q IV ST R S A S L CA A TLAAVLQRIK -- ENK geerl R S TIG V D G SV Y KKH 420
Cdd:PLN02596 369 EDHEVV n E K LK E IFGITDST P MAREV VA -- EV C D IV AE R G A R L AG A GIVGIIKKLG ri ENK ----- K S VVT V E G GL Y EHY 441
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 530367515 421 PH F AKR LH KT V RRLV p G CD ---- V RFLR S ED GSG K GA AMVT A 458
Cdd:PLN02596 442 RV F RNY LH SS V WEML - G SE lsdn V VIEH S HG GSG A GA LFLA A 482
PLN02596
PLN02596
hexokinase-like
483-927
5.14e-48
hexokinase-like
Pssm-ID: 178206
Cd Length: 490
Bit Score: 178.53
E-value: 5.14e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 Q L L EV KRRMKVE M ERG L SK E THAS ap VK ML PT YV CAT P D G T EKG DFLA L D L G G T NF RV L LV R VRNGKWGGVEMHNKIYA I 562
Cdd:PLN02596 55 K L W EV ADALVSD M TAS L TA E ETTT -- LN ML VS YV ASL P S G D EKG LYYG L N L R G S NF LL L RA R LGGKNEPISDLYREEIS I 132
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 563 P QE V MH GT GD ELFD H I VQCI A D F LEYMGMKGVSL P ----- LGFT F S F P cqqns L D EVT A P S WR A LL W alltlnktsqsil 637
Cdd:PLN02596 133 P SN V LN GT SQ ELFD Y I ALEL A K F VAEHPGDEADT P ervkk LGFT V S Y P ----- V D QAA A S S GS A IK W ------------- 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 638 lkwt K G F K A SGCE G EDV V TLLKE A IHR r EEFDLD V V A V V N DT V G TMMTCGFEDPHCEVGLIV G T G S NA C Y M E EMRNVELV 717
Cdd:PLN02596 195 ---- K S F S A DDTV G KAL V NDINR A LEK - HGLKIR V F A L V D DT I G NLAGGRYYNKDTVAAVTL G M G T NA A Y V E PAQAIPKW 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 718 EG --- E EGRMCVNM EWG A F G dng CLDDFR TEFD VAV D EL S L NPG KQR FEK MI SGMYLGEIVR NI L IDFTKRGL LF RGRIS 794
Cdd:PLN02596 270 QS psp E SQEIVIST EWG N F N --- SCHLPI TEFD ASL D AE S S NPG SRI FEK LT SGMYLGEIVR RV L LKMAEETA LF GDTLP 346
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 795 ER L K T RGIFETKFLSQIES D CLALLQ V -- RAILQHL G L - E ST CDDSII V K EVC TV VA R R A A Q L C GAG MAAVVDRIR -- EN 869
Cdd:PLN02596 347 PK L T T PYLLRSPDMAAMHQ D TSEDHE V vn EKLKEIF G I t D ST PMAREV V A EVC DI VA E R G A R L A GAG IVGIIKKLG ri EN 426
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 870 R gldal K VT V G V D G T LY KLHPH F AKVM H ET V ----- KD L AP kc D V SFLQ S ED GSG K GA ALIT A 927
Cdd:PLN02596 427 K ----- K SV V T V E G G LY EHYRV F RNYL H SS V wemlg SE L SD -- N V VIEH S HG GSG A GA LFLA A 482
NBD_sugar-kinase_HSP70_actin
cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
81-262
8.83e-13
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.
Pssm-ID: 212657 [Multi-domain]
Cd Length: 185
Bit Score: 67.61
E-value: 8.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 81 L AL D L G G T NFRVLWVKVTDNG L QKVEMEN qiy AIPEDIMRGSGTQ L FDHIA E C L ANFMDK L qi K DKKLPL G F T FSFPCHQ 160
Cdd:cd00012 1 L GI D I G S T STKAGVADLDGEI L PEEIVPT --- PVGRPGAVTDLDE L EEALR E L L KEALRQ L -- K SEIDAV G I T EPGGVPK 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 161 TKLDESF L VSW tkgfkssgvegrdvva L IRKAIQRRG D FDIDI VAVVND T V GTMMTC G Y -- DDHNCEIGLIV GTG SN acy 238
Cdd:cd00012 76 ENREVII L PNL ---------------- L LIPLALALE D LGGVP VAVVND A V AAALAE G L fg KEEDTVLVVDL GTG TT --- 136
170 180
....*....|....*....|....
gi 530367515 239 meemr H I DM VE GDE G RMCINM E W G 262
Cdd:cd00012 137 ----- G I AI VE DGK G GVGAAG E L G 155
NBD_sugar-kinase_HSP70_actin
cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
529-720
2.69e-10
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.
Pssm-ID: 212657 [Multi-domain]
Cd Length: 185
Bit Score: 60.30
E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 529 L AL D L G G T NFRVLLVR vrngk WG G VEMHNK I YAI P QEVMHG -- TG DEL FDHIVQCIADF L EYMGMKG vs LPL G F T FSFPC 606
Cdd:cd00012 1 L GI D I G S T STKAGVAD ----- LD G EILPEE I VPT P VGRPGA vt DL DEL EEALRELLKEA L RQLKSEI -- DAV G I T EPGGV 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 607 QQNSLDEVTA P SW rallwalltlnktsqsillkwtkgfkasgcegedvvt LL KEAIHRR E EFDLDV VAVVND T V GTMMTC 686
Cdd:cd00012 74 PKENREVIIL P NL ------------------------------------- LL IPLALAL E DLGGVP VAVVND A V AAALAE 116
170 180 190
....*....|....*....|....*....|....*..
gi 530367515 687 G F -- EDPHCEVGLIV GTG S - NACYM E EMRNVELVE GE 720
Cdd:cd00012 117 G L fg KEEDTVLVVDL GTG T t GIAIV E DGKGGVGAA GE 153
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.20
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01