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Conserved domains on  [gi|530367515|ref|XP_005264337|]
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hexokinase-2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02914 super family cl42853
hexokinase
12-460 5.70e-118

hexokinase


The actual alignment was detected with superfamily member PTZ00107:

Pssm-ID: 456198 [Multi-domain]  Cd Length: 464  Bit Score: 368.23  E-value: 5.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  12 TELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGL-GATTHPTA------AVKMLPTFVRSTPDGTEHGEFLALD 84
Cdd:PTZ00107   1 EMRYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  85 LGGTNFRVLWVKVTDNGlqKVEMENQIYAIPEDIMRG---------SGTQLFDHIAECLANFMDKLQIKD---KKLPLGF 152
Cdd:PTZ00107  81 FGGTNFRAVRVSLRGGG--KMERTQSKFSLPKSALLGekglldkkaTATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPCHQTKLDESFLVSWTKGFKSS-----GVEGRDVVALIRKAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDH----N 223
Cdd:PTZ00107 159 TFSFPCTQLSVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFKRNN-VPANVVAVLNDTVGTLISCAYQKPkntpP 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 CEIGLIVGTGSNACYMEemrhiDMVE--GDEGRMcINMEWGAFgdDGSLNdiRTEFDQEIDMGSLNPGKQLFEKMISGMY 301
Cdd:PTZ00107 238 CQVGVIIGTGSNACYFE-----PEVSayGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAY 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 MGELVRLILVKMAKEellfggKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMRL-GLDPTQEDCVATHRICQIVS 379
Cdd:PTZ00107 308 LGEISRRLIVHLLQL------KAPPKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVR 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 TRSASLCAATLAAVLQRIKENKGeerlRSTIGVDGSVYKKHPHFAKRLHKTVRRLV--PGCDVRFLRSEDGSGKGAAMVT 457
Cdd:PTZ00107 382 GRAAQLAAAFIAAPAKKTRTVQG----KATVAIDGSVYVKNPWFRRLLQEYINSILgpDAGNVVFYLADDGSGKGAAIIA 457

                 ...
gi 530367515 458 AVA 460
Cdd:PTZ00107 458 AMV 460
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928 1.00e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


:

Pssm-ID: 427467  Cd Length: 238  Bit Score: 335.23  E-value: 1.00e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  694 EVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMY 770
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  771 LGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESD-CLALLQVRAILQ-HLGLES-TCDDSIIVKEVCTVV 847
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDpSEDLETTREILEeLLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  848 ARRAAQLCGAGMAAVVDRIRENRgldalkVTVGVDGTLYKLHPHFAKVMHETVKDLAP---KCDVSFLQSEDGSGKGAAL 924
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELLGpelEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 530367515  925 ITAV 928
Cdd:pfam03727 235 IAAV 238
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688 4.45e-88

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


:

Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 279.01  E-value: 4.45e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASapVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrnGKW 550
Cdd:pfam00349   3 EELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSSS--LKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--GGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMK---GVSLPLGFTFSFPCQQNSLDEvtapswrallwall 627
Cdd:pfam00349  79 GKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDS-------------- 144
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515  628 tlnktsqSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEfDLDVVAVVNDTVGTMMTCGF 688
Cdd:pfam00349 145 -------GTLIRWTKGFDIPGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
 
Name Accession Description Interval E-value
PTZ00107 PTZ00107
hexokinase; Provisional
12-460 5.70e-118

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 368.23  E-value: 5.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  12 TELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGL-GATTHPTA------AVKMLPTFVRSTPDGTEHGEFLALD 84
Cdd:PTZ00107   1 EMRYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  85 LGGTNFRVLWVKVTDNGlqKVEMENQIYAIPEDIMRG---------SGTQLFDHIAECLANFMDKLQIKD---KKLPLGF 152
Cdd:PTZ00107  81 FGGTNFRAVRVSLRGGG--KMERTQSKFSLPKSALLGekglldkkaTATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPCHQTKLDESFLVSWTKGFKSS-----GVEGRDVVALIRKAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDH----N 223
Cdd:PTZ00107 159 TFSFPCTQLSVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFKRNN-VPANVVAVLNDTVGTLISCAYQKPkntpP 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 CEIGLIVGTGSNACYMEemrhiDMVE--GDEGRMcINMEWGAFgdDGSLNdiRTEFDQEIDMGSLNPGKQLFEKMISGMY 301
Cdd:PTZ00107 238 CQVGVIIGTGSNACYFE-----PEVSayGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAY 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 MGELVRLILVKMAKEellfggKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMRL-GLDPTQEDCVATHRICQIVS 379
Cdd:PTZ00107 308 LGEISRRLIVHLLQL------KAPPKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVR 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 TRSASLCAATLAAVLQRIKENKGeerlRSTIGVDGSVYKKHPHFAKRLHKTVRRLV--PGCDVRFLRSEDGSGKGAAMVT 457
Cdd:PTZ00107 382 GRAAQLAAAFIAAPAKKTRTVQG----KATVAIDGSVYVKNPWFRRLLQEYINSILgpDAGNVVFYLADDGSGKGAAIIA 457

                 ...
gi 530367515 458 AVA 460
Cdd:PTZ00107 458 AMV 460
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928 1.00e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 335.23  E-value: 1.00e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  694 EVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMY 770
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  771 LGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESD-CLALLQVRAILQ-HLGLES-TCDDSIIVKEVCTVV 847
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDpSEDLETTREILEeLLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  848 ARRAAQLCGAGMAAVVDRIRENRgldalkVTVGVDGTLYKLHPHFAKVMHETVKDLAP---KCDVSFLQSEDGSGKGAAL 924
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELLGpelEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 530367515  925 ITAV 928
Cdd:pfam03727 235 IAAV 238
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
225-459 9.46e-105

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 324.83  E-value: 9.46e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  225 EIGLIVGTGSNACYMEEMRHIDMVEGD---EGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMY 301
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGKlpkSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  302 MGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMR-LGL-DPTQEDCVATHRICQIV 378
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIeTCTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  379 STRSASLCAATLAAVLQRIKENkgeerlRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP---GCDVRFLRSEDGSGKGAAM 455
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGG------RVTVGVDGSVYEKYPGFRERLQEALRELLGpelEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 530367515  456 VTAV 459
Cdd:pfam03727 235 IAAV 238
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
34-460 1.04e-104

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 333.22  E-value: 1.04e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  34 ETLLEISKRFRKEMEKGLgaTTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGlqKVEMENQIYA 113
Cdd:COG5026   33 EDLREVVKAFIEELEKGL--QPKSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVLGGDG--TFDIEQSKSF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 114 IPEDIMRG-SGTQLFDHIAECLANFMDK--LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 190
Cdd:COG5026  109 LPVECRDSeSRDELFGFIADRLAAFIKEqhPSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFDIPEVIGTDVVRLLQ 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 KAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGD----EGRMCINMEWGAFgd 266
Cdd:COG5026  189 EALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDdlpeTGPMLINCEWGSF-- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 267 DGSLNDI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIegE 345
Cdd:COG5026  266 DNELSVLpRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPFALSTSVLSRI--E 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 346 KDGIRKAREVLM----RLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKgeerlRSTIGVDGSVYKKHP 421
Cdd:COG5026  344 EDPFENLRNTLTtflnDFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYK-----AYHVGADGSVIERYP 418
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 530367515 422 HFAKRLHKTVRRLVPGCDVRF-LRS-EDGSGKGAAMVTAVA 460
Cdd:COG5026  419 GFRSMLREALKALLGEEGEKIkIKPaEDGSGLGAALCALLA 459
PTZ00107 PTZ00107
hexokinase; Provisional
462-929 3.23e-100

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 321.24  E-value: 3.23e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 462 RLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGL-SKETHASA------PVKMLPTYVCATPDGTEKGDFLALDLG 534
Cdd:PTZ00107   3 RYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAIDFG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 535 GTNFRVLLVRVRNGkwGGVEMHNKIYAIPQEVM---------HGTGDELFDHIVQCIADFLEYMGMK---GVSLPLGFTF 602
Cdd:PTZ00107  83 GTNFRAVRVSLRGG--GKMERTQSKFSLPKSALlgekglldkKATATDLFDHIAKSIKKMMEENGDPedlNKPVPVGFTF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 603 SFPCQQNSLDevtapswrallwalltlnktsQSILLKWTKGFKAS-----GCEGEDVVTLLKEAIhRREEFDLDVVAVVN 677
Cdd:PTZ00107 161 SFPCTQLSVN---------------------NAILIDWTKGFETGratndPVEGKDVGELLNDAF-KRNNVPANVVAVLN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 678 DTVGTMMTCGFED----PHCEVGLIVGTGSNACYMEEMrnvELVEGEEGRMcVNMEWGAFgdngCLDDFRTEFDVAVDEL 753
Cdd:PTZ00107 219 DTVGTLISCAYQKpkntPPCQVGVIIGTGSNACYFEPE---VSAYGYAGTP-INMECGNF----DSKLPITPYDLEMDWY 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 754 SLNPGKQRFEKMISGMYLGEIVRNILIdftkrgLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGLE 831
Cdd:PTZ00107 291 TPNRGRQQFEKMISGAYLGEISRRLIV------HLLQLKAPPKMWQSGSFESEDASMILNDQSPDLQFsrQVIKEAWDVD 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 832 STCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGldalKVTVGVDGTLYKLHPHFAKVMHETVKD-LAPK-CDV 909
Cdd:PTZ00107 365 LTDEDLYTIRKICELVRGRAAQLAAAFIAAPAKKTRTVQG----KATVAIDGSVYVKNPWFRRLLQEYINSiLGPDaGNV 440
                        490       500
                 ....*....|....*....|
gi 530367515 910 SFLQSEDGSGKGAALITAVA 929
Cdd:PTZ00107 441 VFYLADDGSGKGAAIIAAMV 460
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
468-929 1.56e-91

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 298.55  E-value: 1.56e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 468 RARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPvkMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrn 547
Cdd:COG5026   19 QAVEELVESFTVPTEDLREVVKAFIEELEKGLQPKSGDFLP--MIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVL-- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 548 GKWGGVEMHNKIYAIPQEVMHG-TGDELFDHIVQCIADFLE--YMGMKGVSLPLGFTFSFPCQQNSLDEvtapswrallw 624
Cdd:COG5026   95 GGDGTFDIEQSKSFLPVECRDSeSRDELFGFIADRLAAFIKeqHPSGYGSKLPIGFTFSYPLNQTSINE----------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnktsqSILLKWTKGFKASGCEGEDVVTLLKEAIHRREeFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSN 704
Cdd:COG5026  164 ----------GQLIRWTKGFDIPEVIGTDVVRLLQEALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTN 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 ACYMEEMRNVELVEG----EEGRMCVNMEWGAFgDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILI 780
Cdd:COG5026  233 GCYCEPKGRIPKLPRddlpETGPMLINCEWGSF-DNELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILR 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 781 DFTKRGLLFRGRISERLKTRGIFETKFLSQIESD-CLALLQVRA-ILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAG 858
Cdd:COG5026  312 NLYEQGLIFNGQDPEKLTDPFALSTSVLSRIEEDpFENLRNTLTtFLNDFRAPTTKEERKLIRRLVELIGRRAARLAAVP 391
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 859 MAAVVDRIRENRGLDalkvtVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSF-LQS-EDGSGKGAALITAVA 929
Cdd:COG5026  392 IAAIVIKTGAYKAYH-----VGADGSVIERYPGFRSMLREALKALLGEEGEKIkIKPaEDGSGLGAALCALLA 459
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688 4.45e-88

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 279.01  E-value: 4.45e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASapVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrnGKW 550
Cdd:pfam00349   3 EELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSSS--LKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--GGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMK---GVSLPLGFTFSFPCQQNSLDEvtapswrallwall 627
Cdd:pfam00349  79 GKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDS-------------- 144
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515  628 tlnktsqSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEfDLDVVAVVNDTVGTMMTCGF 688
Cdd:pfam00349 145 -------GTLIRWTKGFDIPGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
81-262 8.83e-13

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 67.61  E-value: 8.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  81 LALDLGGTNFRVLWVKVTDNGLQKVEMENqiyAIPEDIMRGSGTQLFDHIAECLANFMDKLqiKDKKLPLGFTFSFPCHQ 160
Cdd:cd00012    1 LGIDIGSTSTKAGVADLDGEILPEEIVPT---PVGRPGAVTDLDELEEALRELLKEALRQL--KSEIDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 161 TKLDESFLVSWtkgfkssgvegrdvvaLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY--DDHNCEIGLIVGTGSNacy 238
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGTT--- 136
                        170       180
                 ....*....|....*....|....
gi 530367515 239 meemrHIDMVEGDEGRMCINMEWG 262
Cdd:cd00012  137 -----GIAIVEDGKGGVGAAGELG 155
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
529-720 2.69e-10

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 60.30  E-value: 2.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 529 LALDLGGTNFRVLLVRvrngkWGGVEMHNKIYAIPQEVMHG--TGDELFDHIVQCIADFLEYMGMKGvsLPLGFTFSFPC 606
Cdd:cd00012    1 LGIDIGSTSTKAGVAD-----LDGEILPEEIVPTPVGRPGAvtDLDELEEALRELLKEALRQLKSEI--DAVGITEPGGV 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 607 QQNSLDEVTAPSWrallwalltlnktsqsillkwtkgfkasgcegedvvtLLKEAIHRREEFDLDVVAVVNDTVGTMMTC 686
Cdd:cd00012   74 PKENREVIILPNL-------------------------------------LLIPLALALEDLGGVPVAVVNDAVAAALAE 116
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530367515 687 GF--EDPHCEVGLIVGTGS-NACYMEEMRNVELVEGE 720
Cdd:cd00012  117 GLfgKEEDTVLVVDLGTGTtGIAIVEDGKGGVGAAGE 153
 
Name Accession Description Interval E-value
PTZ00107 PTZ00107
hexokinase; Provisional
12-460 5.70e-118

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 368.23  E-value: 5.70e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  12 TELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGL-GATTHPTA------AVKMLPTFVRSTPDGTEHGEFLALD 84
Cdd:PTZ00107   1 EMRYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  85 LGGTNFRVLWVKVTDNGlqKVEMENQIYAIPEDIMRG---------SGTQLFDHIAECLANFMDKLQIKD---KKLPLGF 152
Cdd:PTZ00107  81 FGGTNFRAVRVSLRGGG--KMERTQSKFSLPKSALLGekglldkkaTATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 153 TFSFPCHQTKLDESFLVSWTKGFKSS-----GVEGRDVVALIRKAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDH----N 223
Cdd:PTZ00107 159 TFSFPCTQLSVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFKRNN-VPANVVAVLNDTVGTLISCAYQKPkntpP 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 224 CEIGLIVGTGSNACYMEemrhiDMVE--GDEGRMcINMEWGAFgdDGSLNdiRTEFDQEIDMGSLNPGKQLFEKMISGMY 301
Cdd:PTZ00107 238 CQVGVIIGTGSNACYFE-----PEVSayGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAY 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 302 MGELVRLILVKMAKEellfggKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMRL-GLDPTQEDCVATHRICQIVS 379
Cdd:PTZ00107 308 LGEISRRLIVHLLQL------KAPPKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVR 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 380 TRSASLCAATLAAVLQRIKENKGeerlRSTIGVDGSVYKKHPHFAKRLHKTVRRLV--PGCDVRFLRSEDGSGKGAAMVT 457
Cdd:PTZ00107 382 GRAAQLAAAFIAAPAKKTRTVQG----KATVAIDGSVYVKNPWFRRLLQEYINSILgpDAGNVVFYLADDGSGKGAAIIA 457

                 ...
gi 530367515 458 AVA 460
Cdd:PTZ00107 458 AMV 460
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
694-928 1.00e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 335.23  E-value: 1.00e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  694 EVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMY 770
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  771 LGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESD-CLALLQVRAILQ-HLGLES-TCDDSIIVKEVCTVV 847
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDpSEDLETTREILEeLLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  848 ARRAAQLCGAGMAAVVDRIRENRgldalkVTVGVDGTLYKLHPHFAKVMHETVKDLAP---KCDVSFLQSEDGSGKGAAL 924
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELLGpelEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 530367515  925 ITAV 928
Cdd:pfam03727 235 IAAV 238
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
225-459 9.46e-105

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 324.83  E-value: 9.46e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  225 EIGLIVGTGSNACYMEEMRHIDMVEGD---EGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMY 301
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGKlpkSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  302 MGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMR-LGL-DPTQEDCVATHRICQIV 378
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIeTCTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  379 STRSASLCAATLAAVLQRIKENkgeerlRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP---GCDVRFLRSEDGSGKGAAM 455
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGG------RVTVGVDGSVYEKYPGFRERLQEALRELLGpelEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 530367515  456 VTAV 459
Cdd:pfam03727 235 IAAV 238
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
34-460 1.04e-104

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 333.22  E-value: 1.04e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  34 ETLLEISKRFRKEMEKGLgaTTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGlqKVEMENQIYA 113
Cdd:COG5026   33 EDLREVVKAFIEELEKGL--QPKSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVLGGDG--TFDIEQSKSF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 114 IPEDIMRG-SGTQLFDHIAECLANFMDK--LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 190
Cdd:COG5026  109 LPVECRDSeSRDELFGFIADRLAAFIKEqhPSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFDIPEVIGTDVVRLLQ 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 KAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGD----EGRMCINMEWGAFgd 266
Cdd:COG5026  189 EALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDdlpeTGPMLINCEWGSF-- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 267 DGSLNDI-RTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIegE 345
Cdd:COG5026  266 DNELSVLpRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPFALSTSVLSRI--E 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 346 KDGIRKAREVLM----RLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKgeerlRSTIGVDGSVYKKHP 421
Cdd:COG5026  344 EDPFENLRNTLTtflnDFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYK-----AYHVGADGSVIERYP 418
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 530367515 422 HFAKRLHKTVRRLVPGCDVRF-LRS-EDGSGKGAAMVTAVA 460
Cdd:COG5026  419 GFRSMLREALKALLGEEGEKIkIKPaEDGSGLGAALCALLA 459
PTZ00107 PTZ00107
hexokinase; Provisional
462-929 3.23e-100

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 321.24  E-value: 3.23e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 462 RLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGL-SKETHASA------PVKMLPTYVCATPDGTEKGDFLALDLG 534
Cdd:PTZ00107   3 RYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAIDFG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 535 GTNFRVLLVRVRNGkwGGVEMHNKIYAIPQEVM---------HGTGDELFDHIVQCIADFLEYMGMK---GVSLPLGFTF 602
Cdd:PTZ00107  83 GTNFRAVRVSLRGG--GKMERTQSKFSLPKSALlgekglldkKATATDLFDHIAKSIKKMMEENGDPedlNKPVPVGFTF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 603 SFPCQQNSLDevtapswrallwalltlnktsQSILLKWTKGFKAS-----GCEGEDVVTLLKEAIhRREEFDLDVVAVVN 677
Cdd:PTZ00107 161 SFPCTQLSVN---------------------NAILIDWTKGFETGratndPVEGKDVGELLNDAF-KRNNVPANVVAVLN 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 678 DTVGTMMTCGFED----PHCEVGLIVGTGSNACYMEEMrnvELVEGEEGRMcVNMEWGAFgdngCLDDFRTEFDVAVDEL 753
Cdd:PTZ00107 219 DTVGTLISCAYQKpkntPPCQVGVIIGTGSNACYFEPE---VSAYGYAGTP-INMECGNF----DSKLPITPYDLEMDWY 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 754 SLNPGKQRFEKMISGMYLGEIVRNILIdftkrgLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGLE 831
Cdd:PTZ00107 291 TPNRGRQQFEKMISGAYLGEISRRLIV------HLLQLKAPPKMWQSGSFESEDASMILNDQSPDLQFsrQVIKEAWDVD 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 832 STCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGldalKVTVGVDGTLYKLHPHFAKVMHETVKD-LAPK-CDV 909
Cdd:PTZ00107 365 LTDEDLYTIRKICELVRGRAAQLAAAFIAAPAKKTRTVQG----KATVAIDGSVYVKNPWFRRLLQEYINSiLGPDaGNV 440
                        490       500
                 ....*....|....*....|
gi 530367515 910 SFLQSEDGSGKGAALITAVA 929
Cdd:PTZ00107 441 VFYLADDGSGKGAAIIAAMV 460
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
21-219 4.22e-95

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 297.88  E-value: 4.22e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515   21 KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGAttHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDN 100
Cdd:pfam00349   1 ALEELLKQFALSDEKLKEIVDRFVEEMEKGLAK--EGSSSLKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVELGGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  101 GlqKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKD---KKLPLGFTFSFPCHQTKLDESFLVSWTKGFKS 177
Cdd:pfam00349  79 G--KFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEDfeeKELPLGFTFSFPVQQTSLDSGTLIRWTKGFDI 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 530367515  178 SGVEGRDVVALIRKAIQRRGDfDIDIVAVVNDTVGTMMTCGY 219
Cdd:pfam00349 157 PGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
PLN02914 PLN02914
hexokinase
474-927 2.80e-92

hexokinase


Pssm-ID: 178502 [Multi-domain]  Cd Length: 490  Bit Score: 301.03  E-value: 2.80e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 474 LEHLQLSHDQLLEVKRR----MKVEMERGLSKEthASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGK 549
Cdd:PLN02914  41 LTKLQKDCATPLPVLRHvadaMAADMRAGLAVD--GGGDLKMILSYVDSLPSGNEKGLFYALDLGGTNFRVLRVQLGGKD 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 550 WGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMK-----GVSLPLGFTFSFPCQQNSLDevtapswrallw 624
Cdd:PLN02914 119 ERVIATEFEQVSIPQELMFGTSEELFDFIASGLANFVAKEGGKfhlpeGRKREIGFTFSFPVKQTSID------------ 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnktsQSILLKWTKGFKASGCEGEDVVTLLKEAIHRrEEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSN 704
Cdd:PLN02914 187 ---------SGILMKWTKGFAVSGTAGKDVVACLNEAMER-QGLDMRVSALVNDTVGTLAGARYWDDDVMVAVILGTGTN 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 ACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLddfrTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILID 781
Cdd:PLN02914 257 ACYVERTDAIPKLQGqksSSGRTIINTEWGAFSDGLPL----TEFDREMDAASINPGEQIFEKTISGMYLGEIVRRVLLK 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 782 FTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQ-VRAILQH-LGLESTCDDSIIVKEVCTVVARRAAQLCGAGM 859
Cdd:PLN02914 333 MAETSDLFGHFVPEKLSTPFALRTPHLCAMQQDNSDDLQaVGSILYDvLGVEASLSARRRVVEVCDTIVKRGGRLAGAGI 412
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 860 AAVVDRIREN-RGLDALKVT-VGVDGTLYKLHPHFAKVMHETVKD-LAPKC--DVSFLQSEDGSGKGAALITA 927
Cdd:PLN02914 413 VGILEKMEEDsKGMIFGKRTvVAMDGGLYEKYPQYRRYMQDAVTElLGLELskNIAIEHTKDGSGIGAALLAA 485
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
468-929 1.56e-91

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 298.55  E-value: 1.56e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 468 RARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPvkMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrn 547
Cdd:COG5026   19 QAVEELVESFTVPTEDLREVVKAFIEELEKGLQPKSGDFLP--MIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVL-- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 548 GKWGGVEMHNKIYAIPQEVMHG-TGDELFDHIVQCIADFLE--YMGMKGVSLPLGFTFSFPCQQNSLDEvtapswrallw 624
Cdd:COG5026   95 GGDGTFDIEQSKSFLPVECRDSeSRDELFGFIADRLAAFIKeqHPSGYGSKLPIGFTFSYPLNQTSINE----------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 625 alltlnktsqSILLKWTKGFKASGCEGEDVVTLLKEAIHRREeFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSN 704
Cdd:COG5026  164 ----------GQLIRWTKGFDIPEVIGTDVVRLLQEALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTN 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 705 ACYMEEMRNVELVEG----EEGRMCVNMEWGAFgDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILI 780
Cdd:COG5026  233 GCYCEPKGRIPKLPRddlpETGPMLINCEWGSF-DNELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILR 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 781 DFTKRGLLFRGRISERLKTRGIFETKFLSQIESD-CLALLQVRA-ILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAG 858
Cdd:COG5026  312 NLYEQGLIFNGQDPEKLTDPFALSTSVLSRIEEDpFENLRNTLTtFLNDFRAPTTKEERKLIRRLVELIGRRAARLAAVP 391
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 859 MAAVVDRIRENRGLDalkvtVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSF-LQS-EDGSGKGAALITAVA 929
Cdd:COG5026  392 IAAIVIKTGAYKAYH-----VGADGSVIERYPGFRSMLREALKALLGEEGEKIkIKPaEDGSGLGAALCALLA 459
PLN02914 PLN02914
hexokinase
61-458 7.62e-89

hexokinase


Pssm-ID: 178502 [Multi-domain]  Cd Length: 490  Bit Score: 292.17  E-value: 7.62e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDK 140
Cdd:PLN02914  78 LKMILSYVDSLPSGNEKGLFYALDLGGTNFRVLRVQLGGKDERVIATEFEQVSIPQELMFGTSEELFDFIASGLANFVAK 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 141 LQIK-----DKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGdFDIDIVAVVNDTVGTMM 215
Cdd:PLN02914 158 EGGKfhlpeGRKREIGFTFSFPVKQTSIDSGILMKWTKGFAVSGTAGKDVVACLNEAMERQG-LDMRVSALVNDTVGTLA 236
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 216 TCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDE---GRMCINMEWGAFGDDGSLndirTEFDQEIDMGSLNPGKQL 292
Cdd:PLN02914 237 GARYWDDDVMVAVILGTGTNACYVERTDAIPKLQGQKsssGRTIINTEWGAFSDGLPL----TEFDREMDAASINPGEQI 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 293 FEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGE-KDGIRKAREVLMR-LGLDPTQEDCVA 370
Cdd:PLN02914 313 FEKTISGMYLGEIVRRVLLKMAETSDLFGHFVPEKLSTPFALRTPHLCAMQQDnSDDLQAVGSILYDvLGVEASLSARRR 392
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 371 THRICQIVSTRSASLCAATLAAVLQRIKENKgeERL----RSTIGVDGSVYKKHPHFAKRLHKTVRRLVP---GCDVRFL 443
Cdd:PLN02914 393 VVEVCDTIVKRGGRLAGAGIVGILEKMEEDS--KGMifgkRTVVAMDGGLYEKYPQYRRYMQDAVTELLGlelSKNIAIE 470
                        410
                 ....*....|....*
gi 530367515 444 RSEDGSGKGAAMVTA 458
Cdd:PLN02914 471 HTKDGSGIGAALLAA 485
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
471-688 4.45e-88

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 279.01  E-value: 4.45e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASapVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrnGKW 550
Cdd:pfam00349   3 EELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSSS--LKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--GGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMK---GVSLPLGFTFSFPCQQNSLDEvtapswrallwall 627
Cdd:pfam00349  79 GKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDS-------------- 144
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530367515  628 tlnktsqSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEfDLDVVAVVNDTVGTMMTCGF 688
Cdd:pfam00349 145 -------GTLIRWTKGFDIPGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
PLN02405 PLN02405
hexokinase
46-458 2.00e-79

hexokinase


Pssm-ID: 215226 [Multi-domain]  Cd Length: 497  Bit Score: 266.70  E-value: 2.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  46 EMEKGLGatTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKV--TDNGLQKVEMENQiyAIPEDIMRGSG 123
Cdd:PLN02405  65 EMHAGLA--SEGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVLRVLLggKDGRVVKQEFEEV--SIPPHLMTGSS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 124 TQLFDHIAECLANFMDKlQIKDKKLP------LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197
Cdd:PLN02405 141 DALFDFIAAALAKFVAT-EGEDFHLPpgrqreLGFTFSFPVKQTSISSGTLIKWTKGFSIDDAVGQDVVGELTKAMERVG 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 198 dFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGD---EGRMCINMEWGAFGddgSLNDIR 274
Cdd:PLN02405 220 -LDMRVSALVNDTIGTLAGGRYYNPDVVAAVILGTGTNAAYVERAQAIPKWHGLlpkSGEMVINMEWGNFR---SSHLPL 295
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 275 TEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDIS-------------- 340
Cdd:PLN02405 296 TEYDHALDVESLNPGEQIFEKIISGMYLGEILRRVLLKMAEEAAFFGDTVPPKLKIPFILRTPDMSamhhdtspdlkvvg 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 341 ----DIEGEKDGIRKAREVLMRLgldptqedcvathriCQIVSTRSASLCAATLAAVLQRIKEN--KGEERLRSTIGVDG 414
Cdd:PLN02405 376 sklkDILEIPNTSLKMRKVVVEL---------------CNIVATRGARLSAAGIYGILKKLGRDtvKDGEKQKSVIAMDG 440
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 530367515 415 SVYKKHPHFAKRLHKTVRRLVpGCDVR----FLRSEDGSGKGAAMVTA 458
Cdd:PLN02405 441 GLFEHYTEFSKCMESTLKELL-GEEVSesieVEHSNDGSGIGAALLAA 487
PLN02362 PLN02362
hexokinase
483-927 1.17e-75

hexokinase


Pssm-ID: 215206 [Multi-domain]  Cd Length: 509  Bit Score: 257.12  E-value: 1.17e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 QLLEVKRRMKVEMERGLSKEthASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrNGKWGGVEMHN-KIYA 561
Cdd:PLN02362  54 RLRQVVDAMAVEMHAGLASE--GGSKLKMLLTFVDDLPTGSEIGTYYALDLGGTNFRVLRVQL-GGQRSSILSQDvERHP 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 562 IPQEVMHGTGDELFDHIVQCIADFLEYMG-----MKGVSLPLGFTFSFPCQQNSLdevtapswrallwalltlnktSQSI 636
Cdd:PLN02362 131 IPQHLMNSTSEVLFDFIASSLKQFVEKEEngsefSQVRRRELGFTFSFPVKQTSI---------------------SSGI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 637 LLKWTKGFKASGCEGEDVVTLLKEAIHRREeFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVEL 716
Cdd:PLN02362 190 LIKWTKGFAISDMVGKDVAECLQGALNRRG-LDMRVAALVNDTVGTLALGHYHDPDTVAAVIIGTGTNACYLERTDAIIK 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 717 VEG---EEGRMCVNMEWGAFGDNGCLddfRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFrGRI 793
Cdd:PLN02362 269 CQGlltTSGSMVVNMEWGNFWSSHLP---RTSYDIDLDAESPNPNDQGFEKMISGMYLGDIVRRVILRMSQESDIF-GPV 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 794 SERLKTRGIFETKFLSQI-ESDCLALLQVRAILQH-LGL-ESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRI-REN 869
Cdd:PLN02362 345 SSRLSTPFVLRTPSVAAMhEDDSPELQEVARILKEtLGIsEVPLKVRKLVVKICDVVTRRAARLAAAGIVGILKKIgRDG 424
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 870 RGLDAL-----------KVTVGVDGTLYKLHPHFAKVMHETVKDLAPKcDVS----FLQSEDGSGKGAALITA 927
Cdd:PLN02362 425 SGGITSgrsrsdiqimrRTVVAVEGGLYTNYTMFREYLHEALNEILGE-DVAqhviLKATEDGSGIGSALLAA 496
PLN02405 PLN02405
hexokinase
483-927 4.77e-75

hexokinase


Pssm-ID: 215226 [Multi-domain]  Cd Length: 497  Bit Score: 254.76  E-value: 4.77e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 QLLEVKRRMKVEMERGLSKEthASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVrNGKWGG-VEMHNKIYA 561
Cdd:PLN02405  54 KLRQVADAMTVEMHAGLASE--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVLRVLL-GGKDGRvVKQEFEEVS 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 562 IPQEVMHGTGDELFDHIVQCIADFLEYMGmKGVSLP------LGFTFSFPCQQNSLdevtapswrallwalltlnktSQS 635
Cdd:PLN02405 131 IPPHLMTGSSDALFDFIAAALAKFVATEG-EDFHLPpgrqreLGFTFSFPVKQTSI---------------------SSG 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 636 ILLKWTKGFKASGCEGEDVVTLLKEAIhRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE 715
Cdd:PLN02405 189 TLIKWTKGFSIDDAVGQDVVGELTKAM-ERVGLDMRVSALVNDTIGTLAGGRYYNPDVVAAVILGTGTNAAYVERAQAIP 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 716 LVEG---EEGRMCVNMEWGafgdngcldDFR------TEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRG 786
Cdd:PLN02405 268 KWHGllpKSGEMVINMEWG---------NFRsshlplTEYDHALDVESLNPGEQIFEKIISGMYLGEILRRVLLKMAEEA 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 787 LLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLE---STCDDSIIVKEVCTVVARRAAQLCGAGMAAVV 863
Cdd:PLN02405 339 AFFGDTVPPKLKIPFILRTPDMSAMHHDTSPDLKVVGSKLKDILEipnTSLKMRKVVVELCNIVATRGARLSAAGIYGIL 418
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530367515 864 DRIREN--RGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPK---CDVSFLQSEDGSGKGAALITA 927
Cdd:PLN02405 419 KKLGRDtvKDGEKQKSVIAMDGGLFEHYTEFSKCMESTLKELLGEevsESIEVEHSNDGSGIGAALLAA 487
PLN02362 PLN02362
hexokinase
46-458 3.24e-70

hexokinase


Pssm-ID: 215206 [Multi-domain]  Cd Length: 509  Bit Score: 242.09  E-value: 3.24e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  46 EMEKGLgaTTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTD--NGLQKVEMENQiyAIPEDIMRGSG 123
Cdd:PLN02362  65 EMHAGL--ASEGGSKLKMLLTFVDDLPTGSEIGTYYALDLGGTNFRVLRVQLGGqrSSILSQDVERH--PIPQHLMNSTS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 124 TQLFDHIAECLANFMDKLQ-----IKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGd 198
Cdd:PLN02362 141 EVLFDFIASSLKQFVEKEEngsefSQVRRRELGFTFSFPVKQTSISSGILIKWTKGFAISDMVGKDVAECLQGALNRRG- 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 199 FDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWGAFGddgSLNDIRT 275
Cdd:PLN02362 220 LDMRVAALVNDTVGTLALGHYHDPDTVAAVIIGTGTNACYLERTDAIIKCQGlltTSGSMVVNMEWGNFW---SSHLPRT 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 276 EFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG---GKLS-PELLNTGRF---------ETKDISDI 342
Cdd:PLN02362 297 SYDIDLDAESPNPNDQGFEKMISGMYLGDIVRRVILRMSQESDIFGpvsSRLStPFVLRTPSVaamheddspELQEVARI 376
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 343 EGEKDGIR----KAREVLMrlgldptqedcvathRICQIVSTRSASLCAATLAAVLQRIKE----------NKGEERL-- 406
Cdd:PLN02362 377 LKETLGISevplKVRKLVV---------------KICDVVTRRAARLAAAGIVGILKKIGRdgsggitsgrSRSDIQImr 441
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530367515 407 RSTIGVDGSVYKKHPHFAKRLHKTVRRLVpGCDVR----FLRSEDGSGKGAAMVTA 458
Cdd:PLN02362 442 RTVVAVEGGLYTNYTMFREYLHEALNEIL-GEDVAqhviLKATEDGSGIGSALLAA 496
PLN02596 PLN02596
hexokinase-like
36-458 3.43e-52

hexokinase-like


Pssm-ID: 178206  Cd Length: 490  Bit Score: 190.86  E-value: 3.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  36 LLEISKRFRKEMEKGLgaTTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIP 115
Cdd:PLN02596  56 LWEVADALVSDMTASL--TAEETTTLNMLVSYVASLPSGDEKGLYYGLNLRGSNFLLLRARLGGKNEPISDLYREEISIP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 116 EDIMRGSGTQLFDHIAECLANFM-----DKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWtKGFKSSGVEGRDVVALIR 190
Cdd:PLN02596 134 SNVLNGTSQELFDYIALELAKFVaehpgDEADTPERVKKLGFTVSYPVDQAAASSGSAIKW-KSFSADDTVGKALVNDIN 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 191 KAIQRRGdFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWGAFGdd 267
Cdd:PLN02596 213 RALEKHG-LKIRVFALVDDTIGNLAGGRYYNKDTVAAVTLGMGTNAAYVEPAQAIPKWQSpspESQEIVISTEWGNFN-- 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 268 gSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDIS----DIE 343
Cdd:PLN02596 290 -SCHLPITEFDASLDAESSNPGSRIFEKLTSGMYLGEIVRRVLLKMAEETALFGDTLPPKLTTPYLLRSPDMAamhqDTS 368
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 344 GEKDGI-RKAREVLMRLGLDPTQEDCVAthRICQIVSTRSASLCAATLAAVLQRIK--ENKgeerlRSTIGVDGSVYKKH 420
Cdd:PLN02596 369 EDHEVVnEKLKEIFGITDSTPMAREVVA--EVCDIVAERGARLAGAGIVGIIKKLGriENK-----KSVVTVEGGLYEHY 441
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 530367515 421 PHFAKRLHKTVRRLVpGCD----VRFLRSEDGSGKGAAMVTA 458
Cdd:PLN02596 442 RVFRNYLHSSVWEML-GSElsdnVVIEHSHGGSGAGALFLAA 482
PLN02596 PLN02596
hexokinase-like
483-927 5.14e-48

hexokinase-like


Pssm-ID: 178206  Cd Length: 490  Bit Score: 178.53  E-value: 5.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 483 QLLEVKRRMKVEMERGLSKETHASapVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAI 562
Cdd:PLN02596  55 KLWEVADALVSDMTASLTAEETTT--LNMLVSYVASLPSGDEKGLYYGLNLRGSNFLLLRARLGGKNEPISDLYREEISI 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 563 PQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLP-----LGFTFSFPcqqnsLDEVTAPSWRALLWalltlnktsqsil 637
Cdd:PLN02596 133 PSNVLNGTSQELFDYIALELAKFVAEHPGDEADTPervkkLGFTVSYP-----VDQAAASSGSAIKW------------- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 638 lkwtKGFKASGCEGEDVVTLLKEAIHRrEEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELV 717
Cdd:PLN02596 195 ----KSFSADDTVGKALVNDINRALEK-HGLKIRVFALVDDTIGNLAGGRYYNKDTVAAVTLGMGTNAAYVEPAQAIPKW 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 718 EG---EEGRMCVNMEWGAFGdngCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRIS 794
Cdd:PLN02596 270 QSpspESQEIVISTEWGNFN---SCHLPITEFDASLDAESSNPGSRIFEKLTSGMYLGEIVRRVLLKMAEETALFGDTLP 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 795 ERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGL-ESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIR--EN 869
Cdd:PLN02596 347 PKLTTPYLLRSPDMAAMHQDTSEDHEVvnEKLKEIFGItDSTPMAREVVAEVCDIVAERGARLAGAGIVGIIKKLGriEN 426
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530367515 870 RgldalKVTVGVDGTLYKLHPHFAKVMHETV-----KDLAPkcDVSFLQSEDGSGKGAALITA 927
Cdd:PLN02596 427 K-----KSVVTVEGGLYEHYRVFRNYLHSSVwemlgSELSD--NVVIEHSHGGSGAGALFLAA 482
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
81-262 8.83e-13

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 67.61  E-value: 8.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515  81 LALDLGGTNFRVLWVKVTDNGLQKVEMENqiyAIPEDIMRGSGTQLFDHIAECLANFMDKLqiKDKKLPLGFTFSFPCHQ 160
Cdd:cd00012    1 LGIDIGSTSTKAGVADLDGEILPEEIVPT---PVGRPGAVTDLDELEEALRELLKEALRQL--KSEIDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 161 TKLDESFLVSWtkgfkssgvegrdvvaLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGY--DDHNCEIGLIVGTGSNacy 238
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGTT--- 136
                        170       180
                 ....*....|....*....|....
gi 530367515 239 meemrHIDMVEGDEGRMCINMEWG 262
Cdd:cd00012  137 -----GIAIVEDGKGGVGAAGELG 155
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
529-720 2.69e-10

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 60.30  E-value: 2.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 529 LALDLGGTNFRVLLVRvrngkWGGVEMHNKIYAIPQEVMHG--TGDELFDHIVQCIADFLEYMGMKGvsLPLGFTFSFPC 606
Cdd:cd00012    1 LGIDIGSTSTKAGVAD-----LDGEILPEEIVPTPVGRPGAvtDLDELEEALRELLKEALRQLKSEI--DAVGITEPGGV 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530367515 607 QQNSLDEVTAPSWrallwalltlnktsqsillkwtkgfkasgcegedvvtLLKEAIHRREEFDLDVVAVVNDTVGTMMTC 686
Cdd:cd00012   74 PKENREVIILPNL-------------------------------------LLIPLALALEDLGGVPVAVVNDAVAAALAE 116
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 530367515 687 GF--EDPHCEVGLIVGTGS-NACYMEEMRNVELVEGE 720
Cdd:cd00012  117 GLfgKEEDTVLVVDLGTGTtGIAIVEDGKGGVGAAGE 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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