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Conserved domains on  [gi|530369036|ref|XP_005263647|]
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2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X3 [Homo sapiens]

Protein Classification

amidohydrolase family protein( domain architecture ID 10522669)

amidohydrolase family protein similar to 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD), a metal-dependent enzyme that converts ACMS to alpha-aminomuconate semialdehyde (AMS)

Gene Ontology:  GO:0046872|GO:0016787
PubMed:  9144792

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Amidohydro_2 pfam04909
Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.
14-261 5.29e-42

Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.


:

Pssm-ID: 428190 [Multi-domain]  Cd Length: 283  Bit Score: 144.98  E-value: 5.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   14 EAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELF-PVY 92
Cdd:pfam04909  49 VARAVVVAASCRGANNRVAAEALARPGRFLGGVAVVPLDPEDAAAELERAVGEAGFRGVRLNPHPGGDPLLGDRLDrPIY 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   93 AAAERLKCSLFVHPwdmqmdgrmakywlpwLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFS 172
Cdd:pfam04909 129 EALEELGLPVDIHT----------------GFGDRPEDTRAIQPLLLAGVARKFPDLKIVLDHGGGPWIPEGLDDPAALA 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036  173 M---RP----DLCAqdnpmnpkkYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEF--- 242
Cdd:pfam04909 193 LlarRPnvyvKLSG---------LYRDLYFDAPLADRPYLARLLEAFGPDRILFGSDWPHPPLEISPDDGVLLDLPLlla 263
                         250       260
                  ....*....|....*....|
gi 530369036  243 -DEETKNKLKAGNALAFLGL 261
Cdd:pfam04909 264 lSDEEREKILGGNAARLYGL 283
 
Name Accession Description Interval E-value
Amidohydro_2 pfam04909
Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.
14-261 5.29e-42

Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.


Pssm-ID: 428190 [Multi-domain]  Cd Length: 283  Bit Score: 144.98  E-value: 5.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   14 EAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELF-PVY 92
Cdd:pfam04909  49 VARAVVVAASCRGANNRVAAEALARPGRFLGGVAVVPLDPEDAAAELERAVGEAGFRGVRLNPHPGGDPLLGDRLDrPIY 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   93 AAAERLKCSLFVHPwdmqmdgrmakywlpwLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFS 172
Cdd:pfam04909 129 EALEELGLPVDIHT----------------GFGDRPEDTRAIQPLLLAGVARKFPDLKIVLDHGGGPWIPEGLDDPAALA 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036  173 M---RP----DLCAqdnpmnpkkYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEF--- 242
Cdd:pfam04909 193 LlarRPnvyvKLSG---------LYRDLYFDAPLADRPYLARLLEAFGPDRILFGSDWPHPPLEISPDDGVLLDLPLlla 263
                         250       260
                  ....*....|....*....|
gi 530369036  243 -DEETKNKLKAGNALAFLGL 261
Cdd:pfam04909 264 lSDEEREKILGGNAARLYGL 283
COG2159 COG2159
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
5-261 3.49e-29

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 225070  Cd Length: 293  Bit Score: 111.75  E-value: 3.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   5 GPWPGPTSWEAKPEDTLNLCqllNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLN 84
Cdd:COG2159   66 FVLSGMGEVAIIPDLRRALA---NDDLAALAAEYPDRFVGFARVDPRDPEAAAEELERRVRELGFVGVKLHPVAQGFYPD 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036  85 AQELFPVYAAAERLKCSLFVHpwdmqmDGRmakYWLPWlvgmpAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTV 164
Cdd:COG2159  143 DPRLYPIYEAAEELGVPVVIH------TGA---GPGGA-----GLEKGHSDPLYLDDVARKFPELKIVLGHMGEDYPWEL 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036 165 GRISHGfsmrpdlcaqdnPMNPKKYL-GSFYTDALVHDPLSLKLLTdvIGKDKVILGTDYPFplgeLEPGKLIESMEE-- 241
Cdd:COG2159  209 EAIELA------------YAHPNVYLdTSGVRPKYFAPPLLEFLKE--LGPDKILFGSDYPA----IHPEVWLAELDElg 270
                        250       260
                 ....*....|....*....|
gi 530369036 242 FDEETKNKLKAGNALAFLGL 261
Cdd:COG2159  271 LSEEVKEKILGENAARLLGL 290
 
Name Accession Description Interval E-value
Amidohydro_2 pfam04909
Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.
14-261 5.29e-42

Amidohydrolase; These proteins are amidohydrolases that are related to pfam01979.


Pssm-ID: 428190 [Multi-domain]  Cd Length: 283  Bit Score: 144.98  E-value: 5.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   14 EAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELF-PVY 92
Cdd:pfam04909  49 VARAVVVAASCRGANNRVAAEALARPGRFLGGVAVVPLDPEDAAAELERAVGEAGFRGVRLNPHPGGDPLLGDRLDrPIY 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   93 AAAERLKCSLFVHPwdmqmdgrmakywlpwLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFS 172
Cdd:pfam04909 129 EALEELGLPVDIHT----------------GFGDRPEDTRAIQPLLLAGVARKFPDLKIVLDHGGGPWIPEGLDDPAALA 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036  173 M---RP----DLCAqdnpmnpkkYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEF--- 242
Cdd:pfam04909 193 LlarRPnvyvKLSG---------LYRDLYFDAPLADRPYLARLLEAFGPDRILFGSDWPHPPLEISPDDGVLLDLPLlla 263
                         250       260
                  ....*....|....*....|
gi 530369036  243 -DEETKNKLKAGNALAFLGL 261
Cdd:pfam04909 264 lSDEEREKILGGNAARLYGL 283
COG2159 COG2159
Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];
5-261 3.49e-29

Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only];


Pssm-ID: 225070  Cd Length: 293  Bit Score: 111.75  E-value: 3.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036   5 GPWPGPTSWEAKPEDTLNLCqllNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLN 84
Cdd:COG2159   66 FVLSGMGEVAIIPDLRRALA---NDDLAALAAEYPDRFVGFARVDPRDPEAAAEELERRVRELGFVGVKLHPVAQGFYPD 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036  85 AQELFPVYAAAERLKCSLFVHpwdmqmDGRmakYWLPWlvgmpAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTV 164
Cdd:COG2159  143 DPRLYPIYEAAEELGVPVVIH------TGA---GPGGA-----GLEKGHSDPLYLDDVARKFPELKIVLGHMGEDYPWEL 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530369036 165 GRISHGfsmrpdlcaqdnPMNPKKYL-GSFYTDALVHDPLSLKLLTdvIGKDKVILGTDYPFplgeLEPGKLIESMEE-- 241
Cdd:COG2159  209 EAIELA------------YAHPNVYLdTSGVRPKYFAPPLLEFLKE--LGPDKILFGSDYPA----IHPEVWLAELDElg 270
                        250       260
                 ....*....|....*....|
gi 530369036 242 FDEETKNKLKAGNALAFLGL 261
Cdd:COG2159  271 LSEEVKEKILGENAARLLGL 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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