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Conserved domains on  [gi|530413814|ref|XP_005258335|]
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NPC intracellular cholesterol transporter 1 isoform X2 [Homo sapiens]

Protein Classification

2A060601 family protein( domain architecture ID 11489961)

2A060601 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1269 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1916.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814    25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGtawlltstfpsspvlpgEAS 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQN-----------------TPQ 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   340 CCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPF 419
Cdd:TIGR00917  297 RNWGQLSTVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPF 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   420 FRTEQLIIRAPLTDKHiyqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTIL 499
Cdd:TIGR00917  377 YRIEQLIIATVQTSSH----------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIY 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   500 SVLNYFQNSHSVLDHKKGDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALV 579
Cdd:TIGR00917  445 STCKKLQNMYSKLKPENYDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFV 513

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   580 ITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALG 657
Cdd:TIGR00917  514 VTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLG 593

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   658 HMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE-- 735
Cdd:TIGR00917  594 DSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvg 673

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   736 -------TLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQE 808
Cdd:TIGR00917  674 vdneqelTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE 753

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   809 KNRLDIFCCVRGAEDG-----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSM 883
Cdd:TIGR00917  754 DKRVDCFPCIKTSKSSisaekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVL 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   884 PDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDY 963
Cdd:TIGR00917  834 PQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDY 907

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   964 FDWVKPQSSCCRVDNITDQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL 1043
Cdd:TIGR00917  908 LVWLSPQASCCCRKFTNGTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ 985

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1044 lGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSL 1123
Cdd:TIGR00917  986 -GYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIAL 1059

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1124 GAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVER 1203
Cdd:TIGR00917 1060 GAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHR 1139

                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530413814  1204 AEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1269
Cdd:TIGR00917 1140 AKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1269 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1916.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814    25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGtawlltstfpsspvlpgEAS 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQN-----------------TPQ 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   340 CCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPF 419
Cdd:TIGR00917  297 RNWGQLSTVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPF 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   420 FRTEQLIIRAPLTDKHiyqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTIL 499
Cdd:TIGR00917  377 YRIEQLIIATVQTSSH----------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIY 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   500 SVLNYFQNSHSVLDHKKGDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALV 579
Cdd:TIGR00917  445 STCKKLQNMYSKLKPENYDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFV 513

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   580 ITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALG 657
Cdd:TIGR00917  514 VTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLG 593

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   658 HMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE-- 735
Cdd:TIGR00917  594 DSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvg 673

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   736 -------TLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQE 808
Cdd:TIGR00917  674 vdneqelTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE 753

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   809 KNRLDIFCCVRGAEDG-----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSM 883
Cdd:TIGR00917  754 DKRVDCFPCIKTSKSSisaekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVL 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   884 PDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDY 963
Cdd:TIGR00917  834 PQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDY 907

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   964 FDWVKPQSSCCRVDNITDQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL 1043
Cdd:TIGR00917  908 LVWLSPQASCCCRKFTNGTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ 985

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1044 lGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSL 1123
Cdd:TIGR00917  986 -GYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIAL 1059

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1124 GAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVER 1203
Cdd:TIGR00917 1060 GAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHR 1139

                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530413814  1204 AEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1269
Cdd:TIGR00917 1140 AKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-267 1.54e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 303.37  E-value: 1.54e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814    23 QSCVWYGECGI-AYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKkSLFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   102 YNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKda 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   182 dACNATNWIEYMFNKDNGQAPFTITPVF-SDFPVHGMEPMNNATKGCDESVDEvTAPCSCQDCSIVCGPKPQP-PPPPAP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231


                   ....*...
gi 530413814   260 WTILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
353-1276 2.41e-34

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 142.31  E-value: 2.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  353 RRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPffrTEQLIIraplt 432
Cdd:COG1033     1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  433 dkhIYQPYPsgaDVpfgppLDIQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQnshsvl 512
Cdd:COG1033    72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRA------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  513 DHKKGDDFFVYADYHTHFLYCVRAPASLNDtSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNYYN 589
Cdd:COG1033   113 TEGTEDGLTVEPLIPDELPASPEELAELRE-KVLSSP----------------LYVGRLVSPdgkATLIVVTL---DPDP 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  590 DTEKLQRAQAWEkEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVV-ISYAIMFLYISLALGHmkscrrllvd 668
Cdd:COG1033   173 LSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRS---------- 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  669 skVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYqRDERLQGETLDQQLGRVLGEV 748
Cdd:COG1033   242 --LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALRKL 317

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  749 APSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT---CFVSLLGLDIKRQEKNRldifccvrgaedgt 825
Cdd:COG1033   318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK-------------- 383

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  826 svqaSESCLFRFFKNsyspllLKDWMRP---IVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDS-YMVDyFKSISQYLH 901
Cdd:COG1033   384 ----KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpIRQD-LDFIEENFG 452

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  902 AGPPVYFVLEEGHDYtsskgqnmvcggmGCNNDSLVQQIFNAAQ-LDNYTRIGFAPSswIDDYFDWVkpqssccrvdnit 980
Cdd:COG1033   453 GSDPLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKEL------------- 504

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  981 dqfcNASVVDPAcvrcrpltPEGKQRPQGGDFMRFLPMFLSDNPNpkcgkgghaaySSAVNILLGHGTRVGATYFMTYHT 1060
Cdd:COG1033   505 ----NQALNEGD--------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDEDYSAARVTVRLKDLD 561

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1061 VlQTSADFIDALKKArlIASNvtetmgINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGcELWS 1140
Cdd:COG1033   562 S-EEIKALVEEVRAF--LAEN------FPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRL 631

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1141 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMK--GSRVERAEEALAHMGSSV-FS 1217
Cdd:COG1033   632 GLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkgGDLEEAIRRALRTTGKAIlFT 711

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530413814 1218 GITLtkFGGIVVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSVNKAK 1276
Cdd:COG1033   712 SLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1063-1183 1.30e-04

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 46.55  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1063 QTSADFIDALKKARLIASNVTETMGingSAYRVfpysvfYVFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELW 1139
Cdd:NF033617  286 QPGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLR 355

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 530413814 1140 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1183
Cdd:NF033617  356 ATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1269 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1916.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814    25 CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCpGFFFGNVS--LCCDVRQLQTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   103 NLLNLFCELTCSPRQSQFLNVTATEDyvdpvtNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDAD 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   183 ACNATNWIEYMFNKDNGQAPFTITPVFSDFPV-HGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWT 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVsSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   262 ILGLDAMYVIMWITYMAFLLVFFG--AFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGtawlltstfpsspvlpgEAS 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQN-----------------TPQ 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   340 CCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPF 419
Cdd:TIGR00917  297 RNWGQLSTVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPF 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   420 FRTEQLIIRAPLTDKHiyqpypsgadVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNtnCTIL 499
Cdd:TIGR00917  377 YRIEQLIIATVQTSSH----------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIY 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   500 SVLNYFQNSHSVLDHKKGDDFFVyADYHTHFLYCVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALV 579
Cdd:TIGR00917  445 STCKKLQNMYSKLKPENYDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFV 513

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   580 ITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNL--TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALG 657
Cdd:TIGR00917  514 VTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLG 593

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   658 HMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGE-- 735
Cdd:TIGR00917  594 DSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvg 673

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   736 -------TLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQE 808
Cdd:TIGR00917  674 vdneqelTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE 753

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   809 KNRLDIFCCVRGAEDG-----TSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSM 883
Cdd:TIGR00917  754 DKRVDCFPCIKTSKSSisaekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVL 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   884 PDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQifnaaqLDNYTRIGFAPSSWIDDY 963
Cdd:TIGR00917  834 PQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDY 907

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   964 FDWVKPQSSCCRVDNITDQFCNasVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL 1043
Cdd:TIGR00917  908 LVWLSPQASCCCRKFTNGTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQ 985

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1044 lGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTEtmginGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSL 1123
Cdd:TIGR00917  986 -GYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIAL 1059

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1124 GAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVER 1203
Cdd:TIGR00917 1060 GAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHR 1139

                         1210      1220      1230      1240      1250      1260
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530413814  1204 AEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1269
Cdd:TIGR00917 1140 AKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-267 1.54e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 303.37  E-value: 1.54e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814    23 QSCVWYGECGI-AYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKkSLFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   102 YNLLNLFCELTCSPRQSQFLNVTATEdyvdpVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKda 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   182 dACNATNWIEYMFNKDNGQAPFTITPVF-SDFPVHGMEPMNNATKGCDESVDEvTAPCSCQDCSIVCGPKPQP-PPPPAP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231


                   ....*...
gi 530413814   260 WTILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 541-1266 8.90e-75

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 265.76  E-value: 8.90e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   541 NDTSLLHDPCLGTFGGPVFPWLVLGG---YDDQNYNNATALVITFPVNnyYNDTEKLQRAQAWEKEFINFVKN-YKNPNL 616
Cdd:pfam02460  117 NTRIDITYPIMPVLGTPIYLGPHFGGvdfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   617 TISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIG 696
Cdd:pfam02460  195 QFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMG 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   697 LPLTLIVIeVIPFLVLAVGVDNIFILVQAYQRDERLQgeTLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHT 776
Cdd:pfam02460  275 FPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATL--SVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQL 351

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   777 FSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG----AEDGTSV----QASESCLFRFFKNSYSPLLLK 848
Cdd:pfam02460  352 FCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWATSspqrIDSEGSEpdksHNIEQLKSRFFLDIYCPFLLN 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   849 DWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDYTSSKGQNMVcg 927
Cdd:pfam02460  432 PSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTIPESRDRM-- 509

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   928 gmgcnnDSLVQQiFNAAQldnYTRIGFAPSSWIDDYFDWVKPQssccrvdnitdqfcNASVVDpacvrcrpltpEGKQRP 1007
Cdd:pfam02460  510 ------NEMVDE-FENTP---YSLGPNSTLFWLREYENFLSTL--------------NMEEEE-----------DEEKEW 554

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1008 QGGDfmrfLPMFLSDNPNPKCGKGGHAAYSsavnillghGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNvtetmg 1087
Cdd:pfam02460  555 SYGN----LPSFLKAPGNSHWAGDLVWDDN---------TTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQ------ 615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1088 ingsaYRVFPYSVF---YVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCAtIAMVLVNMFGVMWLWGI 1164
Cdd:pfam02460  616 -----YPEFNVTVFdedAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLA-IASIDIGVFGFLSLWGV 689

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1165 SLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTkFGGIVVLAFAKSQIFQIFYFR 1244
Cdd:pfam02460  690 DLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKT 768

                          730       740
                   ....*....|....*....|..
gi 530413814  1245 MYLaMVLLGATHGLIFLPVLLS 1266
Cdd:pfam02460  769 VFL-VVAIGLLHGLFILPIILS 789
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 666-820 6.97e-65

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 216.30  E-value: 6.97e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   666 LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGEtlDQQLGRVL 745
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530413814   746 GEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRG 820
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
598-1270 5.70e-64

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 238.24  E-value: 5.70e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   598 QAWEKEFINFVKNY--KNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghmksCRRLLVDSKVSLGI 675
Cdd:TIGR00918  357 EAWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTM-----LRWDCAKSQGSVGL 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   676 AGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQrdERLQGETLDQQLGRVLGEVAPSMFLS 755
Cdd:TIGR00918  432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEERTGECLKRTGASVVLT 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   756 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGA-------------- 821
Cdd:TIGR00918  510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPcsarviqiepqaya 589

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   822 --------------------EDGTSVQASESC------------------------------------------------ 833
Cdd:TIGR00918  590 dgsappvysshmqstvqlrtEYDPGTQHYYTTneprshlsvqpsdplscqspdiagstrdllsqfedskaaclslpcarw 669

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   834 -LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLhAGPPVYFVLEE 912
Cdd:TIGR00918  670 tLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF-SFYNMYAVTQG 748

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   913 GHDYTSSKgqnmvcggmgcnndslvQQIFNAAQldNYTRI--------GFAPSSWIDDYFDWV----KPQSSCCRVDNIT 980
Cdd:TIGR00918  749 NFDYPTQQ-----------------QLLYDLHQ--SFSSVkyvlkednGQLPRMWLHYFRDWLqglqKAFDEDWRDGRIT 809

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   981 -DQFCNASvvDPACVRCRPLTPEGkQRPQGGDFMRFLPMFLSDNP---NPKCGKGGHAAYSSavNILLGHGTRVGATY-- 1054
Cdd:TIGR00918  810 kENYRNGS--DDAVLAYKLLVQTG-HRDKPVDKEQLTTQRLVNADgiiNPNAFYIYLSAWVS--NDPVAYAASQANIYph 884

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1055 ----------------------------FMTYHTVLQTSADFIDALKKARLIASNVtETMGINGsayrvFPYSVFYVFYE 1106
Cdd:TIGR00918  885 ppewlhdkndydpenlripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNNY-EGFGLPS-----YPSGYPFLFWE 958

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1107 QYLTIIDDTIFNLGVSLGAIFLVTMVLLgCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCS 1186
Cdd:TIGR00918  959 QYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTV 1037

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1187 HITRAFTVSMkGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQI-FQIFYFRMYLAMV-LLGATHGLIFLPVL 1264
Cdd:TIGR00918 1038 HIALGFLTAI-GDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLGVLNGLVLLPVL 1113


                   ....*.
gi 530413814  1265 LSYIGP 1270
Cdd:TIGR00918 1114 LSMFGP 1119
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
353-1276 2.41e-34

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 142.31  E-value: 2.41e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  353 RRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPffrTEQLIIraplt 432
Cdd:COG1033     1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  433 dkhIYQPYPsgaDVpfgppLDIQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQnshsvl 512
Cdd:COG1033    72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTNVRA------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  513 DHKKGDDFFVYADYHTHFLYCVRAPASLNDtSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNYYN 589
Cdd:COG1033   113 TEGTEDGLTVEPLIPDELPASPEELAELRE-KVLSSP----------------LYVGRLVSPdgkATLIVVTL---DPDP 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  590 DTEKLQRAQAWEkEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVV-ISYAIMFLYISLALGHmkscrrllvd 668
Cdd:COG1033   173 LSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRS---------- 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  669 skVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYqRDERLQGETLDQQLGRVLGEV 748
Cdd:COG1033   242 --LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALRKL 317

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  749 APSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQIT---CFVSLLGLDIKRQEKNRldifccvrgaedgt 825
Cdd:COG1033   318 GPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK-------------- 383

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  826 svqaSESCLFRFFKNsyspllLKDWMRP---IVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDS-YMVDyFKSISQYLH 901
Cdd:COG1033   384 ----KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpIRQD-LDFIEENFG 452

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  902 AGPPVYFVLEEGHDYtsskgqnmvcggmGCNNDSLVQQIFNAAQ-LDNYTRIGFAPSswIDDYFDWVkpqssccrvdnit 980
Cdd:COG1033   453 GSDPLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKEL------------- 504

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  981 dqfcNASVVDPAcvrcrpltPEGKQRPQGGDFMRFLPMFLSDNPNpkcgkgghaaySSAVNILLGHGTRVGATYFMTYHT 1060
Cdd:COG1033   505 ----NQALNEGD--------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDEDYSAARVTVRLKDLD 561

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1061 VlQTSADFIDALKKArlIASNvtetmgINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGcELWS 1140
Cdd:COG1033   562 S-EEIKALVEEVRAF--LAEN------FPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRL 631

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1141 AVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMK--GSRVERAEEALAHMGSSV-FS 1217
Cdd:COG1033   632 GLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRkgGDLEEAIRRALRTTGKAIlFT 711

                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530413814 1218 GITLtkFGGIVVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSVNKAK 1276
Cdd:COG1033   712 SLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
352-800 4.61e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 80.29  E-value: 4.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  352 LRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDlWSAPSSQARLEKEYFDQHFGPFFRTEqLIIRAPl 431
Cdd:COG1033   388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGSDPLE-VVVDTG- 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  432 TDKHIYQPypsgadvpfgppldiQILHQVLDLQIAIENItasydnETVTlqdiclaplspyntncTILSVLNYFQNSHSV 511
Cdd:COG1033   465 EPDGLKDP---------------EVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVKELNQA 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  512 LDhkkGDDFFVYAdyhthflycvrapasLNDTSLLHDPCLGTFGGPvfPWLVLGGYDDQNYNNAtalVITFPVNNyyNDT 591
Cdd:COG1033   508 LN---EGDPKYYA---------------LPESRELLAQLLLLLSSP--PGDDLSRFVDEDYSAA---RVTVRLKD--LDS 562

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  592 EKLQRAQAWEKEFINfvKNYKNPNLTISFTAERSIEDELNRESDSD-VFTVVISYAIMFLYISLALGhmkscrrllvdsK 670
Cdd:COG1033   563 EEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESVIESqIRSLLLALLLIFLLLLLAFR------------S 628

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  671 VSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDN-IFILvqAYQRDERLQGETLDQQLGRVLGEVA 749
Cdd:COG1033   629 LRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALRTTG 705

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530413814  750 PSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLL 800
Cdd:COG1033   706 KAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1111-1277 2.90e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 71.43  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1111 IIDDTIFNLGVSLGAIFLVTMVLLGCeLWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITR 1190
Cdd:COG1033   216 IQSDLAIFFPLALLLILLLLFLFFRS-LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLN 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1191 AFTVSMK--GSRVERAEEALAHMGSSVFSGiTLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHgLIFLPVLLSYI 1268
Cdd:COG1033   295 RYREERRkgLDKREALREALRKLGPPVLLT-SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLL 372


                  ....*....
gi 530413814 1269 GPSVNKAKS 1277
Cdd:COG1033   373 PRPKPKTRR 381
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 588-817 1.15e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 62.93  E-value: 1.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   588 YNDTEKlqraqawEKEFINFVKNYK---NPNLTISFTAERSIEDELNResdsdvfTVVISYAIMFLYIslalghmkscrr 664
Cdd:TIGR00921  157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVLVL------------ 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   665 LLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAYQrDERLQGETLDQQLGRV 744
Cdd:TIGR00921  211 LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYGIQTLNRYE-EERDIGRAKGEAIVTA 288

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530413814   745 LGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 817
Cdd:TIGR00921  289 VRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEIIAI 361
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 675-802 6.41e-09

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 59.23  E-value: 6.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   675 IAGILIVLS---SVACSLG---VFSYI-GLPLTLIVIEVIPFLVLAVGVD-NIFiLVQAYqRDERLQGETLDQQLGRVLG 746
Cdd:pfam03176  167 VAALLPLLTvglSLGAAQGlvaILAHIlGIGLSTFALNLLVVLLIAVGTDyALF-LVSRY-REELRAGEDREEAVIRAVR 244

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530413814   747 EVAPSMFLSSFseTVAFFLGALSV--MPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 802
Cdd:pfam03176  245 GTGKVVTAAGL--TVAIAMLALSFarLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1112-1276 3.92e-08

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 58.19  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1112 IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISV-------Ef 1184
Cdd:COG0841   330 IEEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaivvvE- 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1185 csHITRafTVSMKGSRVERAEEALAHMGSSVFSgITLTKfggIVV---LAFAKSQIFQIFYfrmYLAMVLLGAT-----H 1256
Cdd:COG0841   408 --NIER--HMEEGLSPLEAAIKGAREVAGAVIA-STLTL---VAVflpLAFMGGITGQLFR---QFALTVAIALlislfV 476

                         170       180
                  ....*....|....*....|
gi 530413814 1257 GLIFLPVLLSYIGPSVNKAK 1276
Cdd:COG0841   477 ALTLTPALCARLLKPHPKGK 496
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 636-809 2.70e-06

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 51.78  E-value: 2.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   636 SDVFTVVISYAIMFLYISLALGHMkscRRLlvDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIViEVIPFLVLAVG 715
Cdd:TIGR00920   60 SDVIVMTITRCIAVLYIYYQFCNL---RQL--GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EALPFFLLLID 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   716 VDNIFILVQaYQRDERLQGETLDqQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITC 795
Cdd:TIGR00920  134 LSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTF 211

                          170
                   ....*....|....*..
gi 530413814   796 F---VSLLgLDIKRQEK 809
Cdd:TIGR00920  212 FpacLSLV-LELSRSGR 227
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1096-1266 1.04e-05

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 49.99  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1096 FPYSVFY-VFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSL 1171
Cdd:pfam00873  310 FPQGVEIvVVYDTTPFIrasIEEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTL 388

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1172 VNLVMSCGISV-------EFCSHITRA-----FTVSMKGSR-VERAEEALAHMGSSVFsgITLTKFGGIVvlafakSQIF 1238
Cdd:pfam00873  389 GGLVLAIGLVVddaivvvENIERVLEEnglkpLEAAYKSMGeIGGALVAIALVLSAVF--LPILFLGGLT------GRIF 460

                          170       180
                   ....*....|....*....|....*...
gi 530413814  1239 QIFYFRMYLAMvLLGATHGLIFLPVLLS 1266
Cdd:pfam00873  461 RQFAITIVLAI-LLSVLVALTLTPALCA 487
COG4258 COG4258
Predicted exporter [General function prediction only];
643-791 1.22e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.85  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  643 ISYAIMFLYISLALGhmkSCRRLLVdskvslgiagILIV-LSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVD-NIF 720
Cdd:COG4258   647 LALLLILLLLLLRLR---SLRRALR----------VLLPpLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALF 712

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530413814  721 ILVQAYQRDERLqgetldqqlgRVLgevaPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLL 791
Cdd:COG4258   713 FTEGLLDKGELA----------RTL----LSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1112-1232 5.79e-05

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 47.72  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1112 IDDTIFNLGVSL--GAIfLVTMVL---LGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCG------- 1179
Cdd:COG3696   330 IDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdgav 407

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530413814 1180 ISVEFC-SHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITltkfggIVVLAF 1232
Cdd:COG3696   408 VMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1063-1183 1.30e-04

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 46.55  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1063 QTSADFIDALKKARLIASNVTETMGingSAYRVfpysvfYVFYEQYLTI---IDDTIFNLGVSLGAIFLVTMVLLGcELW 1139
Cdd:NF033617  286 QPGANPIEVADEIRALLPELQETLP---KNIKV------NVLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLR 355

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 530413814 1140 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1183
Cdd:NF033617  356 ATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
COG4258 COG4258
Predicted exporter [General function prediction only];
1104-1277 1.49e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 46.38  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1104 FYEQYLtiiDDTIFNLGVSLGAIFLVTMVLLGcELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1183
Cdd:COG4258   633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814 1184 FCSHITRAFTvsmkgsrveRAEEALAHMGSSVFSGI-TLTKFGgivVLAFAKSQIFQIFYfrmylAMVLLGathglIFLP 1262
Cdd:COG4258   709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPALRSFG-----LTVLLG-----ILLA 766

                         170
                  ....*....|....*
gi 530413814 1263 VLLSYIGPSVNKAKS 1277
Cdd:COG4258   767 LLLAPLLAPRRRPRR 781
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 614-802 3.69e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 3.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   614 PNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALghmksCRRLLVdskvslGIAGILIVLSSVACSLGVFS 693
Cdd:TIGR00921  545 PGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAV-----FRNPIK------AVFPLIAIGSGILWAIGLMG 613

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814   694 YIGLPLTLIVIEVIPfLVLAVGVDNIFILVQAY--QRDERLQGETLDQQLGRVlgevAPSMFLSSFseTVAFFLGAL--S 769
Cdd:TIGR00921  614 LRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMERT----GPGILFSGL--TTAGGFLSLllS 686

                          170       180       190
                   ....*....|....*....|....*....|...
gi 530413814   770 VMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGL 802
Cdd:TIGR00921  687 HFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 614-794 4.45e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 44.76  E-value: 4.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  614 PNLTISFTAERSIEDELNRESDSD-----VFTVVISYAIMFLyislALGhmkscrrllvdskvSLGIAG--ILIVLSSVA 686
Cdd:COG2409   147 PGLTVYVTGPAALAADLNEAFEEDlgraeLITLPVALVVLLL----VFR--------------SLVAALlpLLTAGLAVG 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  687 CSLGVFSYIG--LPLTLIVIEVIPFLVLAVGVD-NIFILvqAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFseTVAF 763
Cdd:COG2409   209 VALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLV--SRYREELRAGEDREEAVARAVATAGRAVLFSGL--TVAI 284

                         170       180       190
                  ....*....|....*....|....*....|...
gi 530413814  764 FLGALSV--MPAVHTFSLFAGLAVFIDFLLQIT 794
Cdd:COG2409   285 ALLGLLLagLPFLRSMGPAAAIGVAVAVLAALT 317
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1117-1293 2.44e-03

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 42.13  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1117 FNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAF--T 1193
Cdd:TIGR00921  195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeE 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530413814  1194 VSMKGSRVERAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQIFQIFYFRMYLAM-VLLGATHGLIFLPVLLSYIGPSV 1272
Cdd:TIGR00921  275 RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSIDIGR 351

                          170       180
                   ....*....|....*....|.
gi 530413814  1273 NKAKSCATEERYKGTERERLL 1293
Cdd:TIGR00921  352 EKVKKEIIAIGGKSSEIEEEL 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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