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Conserved domains on  [gi|530396073|ref|XP_005253322.1|]
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autophagy-related protein 13 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATG13 super family cl12374
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 1.70e-06

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


The actual alignment was detected with superfamily member pfam10033:

Pssm-ID: 313287  Cd Length: 232  Bit Score: 49.13  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   3 FF-TKAALLILQSRLNLPPSSSSSGSKKVNKWFNLELDDTDDFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   90 --------EG---DSME------------LEIWCLEMNEK------CDKEIKVSYTVYNRlslllksllAI--------- 131
Cdd:pfam10033  78 qslvlkddDGkrwDVDKalsgggkkteivLERWLIELDPTsstfpsDFGSILELPTVYKK---------AIvlfrslytl 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  132 TRVTPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRI 191
Cdd:pfam10033 149 LRLLPAWKLYRrlnksKNSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPVETPLGRLRISVSYRN 228

                  ....
gi 530396073  192 NLAF 195
Cdd:pfam10033 229 DCDF 232
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 1.70e-06

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


Pssm-ID: 313287  Cd Length: 232  Bit Score: 49.13  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   3 FF-TKAALLILQSRLNLPPSSSSSGSKKVNKWFNLELDDTDDFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   90 --------EG---DSME------------LEIWCLEMNEK------CDKEIKVSYTVYNRlslllksllAI--------- 131
Cdd:pfam10033  78 qslvlkddDGkrwDVDKalsgggkkteivLERWLIELDPTsstfpsDFGSILELPTVYKK---------AIvlfrslytl 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  132 TRVTPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRI 191
Cdd:pfam10033 149 LRLLPAWKLYRrlnksKNSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPVETPLGRLRISVSYRN 228

                  ....
gi 530396073  192 NLAF 195
Cdd:pfam10033 229 DCDF 232
 
Name Accession Description Interval E-value
ATG13 pfam10033
Autophagy-related protein 13; Members of this family of phosphoproteins are involved in ...
19-195 1.70e-06

Autophagy-related protein 13; Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage.


Pssm-ID: 313287  Cd Length: 232  Bit Score: 49.13  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   19 FFaLKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKK----ALAGQLPAvgrsMCVEISLKTS----- 89
Cdd:pfam10033   3 FF-TKAALLILQSRLNLPPSSSSSGSKKVNKWFNLELDDTDDFREELRLwrscDSLSENPP----LVIETYLDLSdlspn 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073   90 --------EG---DSME------------LEIWCLEMNEK------CDKEIKVSYTVYNRlslllksllAI--------- 131
Cdd:pfam10033  78 qslvlkddDGkrwDVDKalsgggkkteivLERWLIELDPTsstfpsDFGSILELPTVYKK---------AIvlfrslytl 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396073  132 TRVTPAYRLSR-----KQGHEYVIL-YRIYFGEVQLSGLGE-GF-------------QTVRVGTVGTPVGTITLSCAYRI 191
Cdd:pfam10033 149 LRLLPAWKLYRrlnksKNSHPALKLgCRILDGSKPILSKGRdGLskplipsysnvhlEQYKFTPVETPLGRLRISVSYRN 228

                  ....
gi 530396073  192 NLAF 195
Cdd:pfam10033 229 DCDF 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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