NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530378914|ref|XP_005248407|]
View 

ciliogenesis and planar polarity effector 1 isoform X12 [Homo sapiens]

Protein Classification

Joubert domain-containing protein( domain architecture ID 10634118)

Joubert domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Joubert pfam15392
Joubert syndrome-associated; This family of proteins is domain of unknown function, which is ...
2871-3201 0e+00

Joubert syndrome-associated; This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.


:

Pssm-ID: 434690  Cd Length: 322  Bit Score: 578.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2871 GVSSEELGLTE-QAMGTSRIQHYSGRHSQRTDKERREIQAWMKRKRKERMAKYLNELAEKRGQEHDPFCPRSNPLYMTSR 2949
Cdd:pfam15392   15 GVSSEELGLTEqQARSISRIQHSSGRRPQRTEKERREIQAWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRSNPFYMTSR 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2950 EIRLRQKMKHEKDRLLLSEHYSRRISQAYGLMNELLSESVQLPTLPQKPLPNKPSPTQSSSCQHCPSPRGENQHGHSFLI 3029
Cdd:pfam15392   95 EIRLRQKMKHEKDRLLLSDHYSRRISQAYSLMNELLSESVQLPATAQKPLPNKPRTAQSSRRQRCPSPRRENRHGHNFPI 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3030 NRPGKVKYMSKPSYIHKrksfgqpqgspwphgtatftiqKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAG 3109
Cdd:pfam15392  175 NRPGKVRHISKSSYTQK----------------------GKPGGAKRAVRKAVQSPVTRRKGSNAPCRSLQHTKSRGSAG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3110 LAPQTKQVCVEYEREETVVSPWTIPSEIHKILHESHNSLLQDLSptEEEEPEHPFGVGGVDSVSESTGSILSKLDWNAIE 3189
Cdd:pfam15392  233 LAPPTKQVCIEYEREETVVSPWTLPSDIHRILHESPSSLLQDLS--PAEEEKPPLGVGGMDSVSESTGSILSKLDWNAIE 310
                          330
                   ....*....|..
gi 530378914  3190 DMVASVEDQGLS 3201
Cdd:pfam15392  311 DMVASVEDKSLS 322
 
Name Accession Description Interval E-value
Joubert pfam15392
Joubert syndrome-associated; This family of proteins is domain of unknown function, which is ...
2871-3201 0e+00

Joubert syndrome-associated; This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.


Pssm-ID: 434690  Cd Length: 322  Bit Score: 578.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2871 GVSSEELGLTE-QAMGTSRIQHYSGRHSQRTDKERREIQAWMKRKRKERMAKYLNELAEKRGQEHDPFCPRSNPLYMTSR 2949
Cdd:pfam15392   15 GVSSEELGLTEqQARSISRIQHSSGRRPQRTEKERREIQAWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRSNPFYMTSR 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2950 EIRLRQKMKHEKDRLLLSEHYSRRISQAYGLMNELLSESVQLPTLPQKPLPNKPSPTQSSSCQHCPSPRGENQHGHSFLI 3029
Cdd:pfam15392   95 EIRLRQKMKHEKDRLLLSDHYSRRISQAYSLMNELLSESVQLPATAQKPLPNKPRTAQSSRRQRCPSPRRENRHGHNFPI 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3030 NRPGKVKYMSKPSYIHKrksfgqpqgspwphgtatftiqKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAG 3109
Cdd:pfam15392  175 NRPGKVRHISKSSYTQK----------------------GKPGGAKRAVRKAVQSPVTRRKGSNAPCRSLQHTKSRGSAG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3110 LAPQTKQVCVEYEREETVVSPWTIPSEIHKILHESHNSLLQDLSptEEEEPEHPFGVGGVDSVSESTGSILSKLDWNAIE 3189
Cdd:pfam15392  233 LAPPTKQVCIEYEREETVVSPWTLPSDIHRILHESPSSLLQDLS--PAEEEKPPLGVGGMDSVSESTGSILSKLDWNAIE 310
                          330
                   ....*....|..
gi 530378914  3190 DMVASVEDQGLS 3201
Cdd:pfam15392  311 DMVASVEDKSLS 322
 
Name Accession Description Interval E-value
Joubert pfam15392
Joubert syndrome-associated; This family of proteins is domain of unknown function, which is ...
2871-3201 0e+00

Joubert syndrome-associated; This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.


Pssm-ID: 434690  Cd Length: 322  Bit Score: 578.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2871 GVSSEELGLTE-QAMGTSRIQHYSGRHSQRTDKERREIQAWMKRKRKERMAKYLNELAEKRGQEHDPFCPRSNPLYMTSR 2949
Cdd:pfam15392   15 GVSSEELGLTEqQARSISRIQHSSGRRPQRTEKERREIQAWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRSNPFYMTSR 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  2950 EIRLRQKMKHEKDRLLLSEHYSRRISQAYGLMNELLSESVQLPTLPQKPLPNKPSPTQSSSCQHCPSPRGENQHGHSFLI 3029
Cdd:pfam15392   95 EIRLRQKMKHEKDRLLLSDHYSRRISQAYSLMNELLSESVQLPATAQKPLPNKPRTAQSSRRQRCPSPRRENRHGHNFPI 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3030 NRPGKVKYMSKPSYIHKrksfgqpqgspwphgtatftiqKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAG 3109
Cdd:pfam15392  175 NRPGKVRHISKSSYTQK----------------------GKPGGAKRAVRKAVQSPVTRRKGSNAPCRSLQHTKSRGSAG 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378914  3110 LAPQTKQVCVEYEREETVVSPWTIPSEIHKILHESHNSLLQDLSptEEEEPEHPFGVGGVDSVSESTGSILSKLDWNAIE 3189
Cdd:pfam15392  233 LAPPTKQVCIEYEREETVVSPWTLPSDIHRILHESPSSLLQDLS--PAEEEKPPLGVGGMDSVSESTGSILSKLDWNAIE 310
                          330
                   ....*....|..
gi 530378914  3190 DMVASVEDQGLS 3201
Cdd:pfam15392  311 DMVASVEDKSLS 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH