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Conserved domains on  [gi|528499110|ref|XP_005173126|]
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F-box and WD repeat domain containing 11a isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-538 4.91e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 242.63  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDDK--IISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:cd00200    9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRF--CNGLMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 487
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 488 WDLQaaldprapaSTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:cd00200  246 WDLR---------TGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 136-186 9.82e-31

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438954  Cd Length: 51  Bit Score: 113.46  E-value: 9.82e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528499110 136 QRDFITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKK 186
Cdd:cd22183    1 QRDFITALPAKGLDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 98-136 3.04e-24

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


:

Pssm-ID: 463465  Cd Length: 39  Bit Score: 95.13  E-value: 3.04e-24
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528499110   98 QLFDQWSESDQVEFVEHLIARMCHYQHGHINSYLKPMLQ 136
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-538 4.91e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 242.63  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDDK--IISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:cd00200    9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRF--CNGLMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 487
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 488 WDLQaaldprapaSTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:cd00200  246 WDLR---------TGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
260-538 8.38e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 8.38e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDD--KIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:COG2319  120 TGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRFC-NG-LMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:COG2319  200 LTGHTGAVRSVAFSpDGkLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 487
Cdd:COG2319  277 TGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRL 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 488 WDLqaaldprapASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:COG2319  357 WDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 136-186 9.82e-31

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 113.46  E-value: 9.82e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528499110 136 QRDFITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKK 186
Cdd:cd22183    1 QRDFITALPAKGLDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 98-136 3.04e-24

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 95.13  E-value: 3.04e-24
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528499110   98 QLFDQWSESDQVEFVEHLIARMCHYQHGHINSYLKPMLQ 136
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 97-136 7.64e-21

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 85.62  E-value: 7.64e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110    97 IQLFDQWSESDQVEFVEHLIARMCHYQHGHINSYLKPMLQ 136
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 396-558 5.72e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 5.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 396 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 472
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 473 N---KRIVSGAYDGKIKVWDLQaalDPRAPastLClrTLVEHSGRVFRLQF-DEFQIISSSHDDTILIWDfLNVSSNGQS 548
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDLR---NPKLP---LC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWD-LSMSISGIN 697

                        170
                 ....*....|
gi 528499110 549 DgrSPSRTYT 558
Cdd:PLN00181 698 E--TPLHSFM 705
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 140-187 5.20e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.10  E-value: 5.20e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 528499110  140 ITALParglDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-326 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110   289 SLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
291-326 6.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528499110  291 ECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 326
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
149-187 7.05e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.89  E-value: 7.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528499110   149 DHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-538 4.91e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 242.63  E-value: 4.91e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDDK--IISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:cd00200    9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRF--CNGLMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:cd00200   89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 487
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 488 WDLQaaldprapaSTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:cd00200  246 WDLR---------TGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
260-538 8.38e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 8.38e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDD--KIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:COG2319  120 TGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRFC-NG-LMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:COG2319  200 LTGHTGAVRSVAFSpDGkLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 487
Cdd:COG2319  277 TGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRL 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 488 WDLqaaldprapASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:COG2319  357 WDL---------ATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
260-491 1.21e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 1.21e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQYDDD--KIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:COG2319  162 SGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRFC-NG-LMVTCSKDRSIAVWDMASAtdiSLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:COG2319  242 LTGHSGSVRSVAFSpDGrLLASGSADGTVRLWDLATG---ELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 412 TCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKV 487
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRL 398


                 ....
gi 528499110 488 WDLQ 491
Cdd:COG2319  399 WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 292-541 8.97e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 8.97e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 292 CLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNTLIHHNEAVLHLRFC--NGLMVTCSKDRSIAVWDM 367
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 368 ASAtdiSLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDN 443
Cdd:cd00200   81 ETG---ECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSpdGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 444 TIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQaaldprapaSTLCLRTLVEHSGRVFRLQFD 521
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLS---------TGKCLGTLRGHENGVNSVAFS 228

                        250       260
                 ....*....|....*....|..
gi 528499110 522 EFQ--IISSSHDDTILIWDFLN 541
Cdd:cd00200  229 PDGylLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
269-538 1.41e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.34  E-value: 1.41e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 269 DDDKIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNTLIHHNEAVLHL 346
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 347 RF--CNGLMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGH 422
Cdd:COG2319   85 AFspDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 423 KRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLqaaldpra 498
Cdd:COG2319  162 SGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDL-------- 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 528499110 499 pASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:COG2319  234 -ATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
260-412 2.75e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 2.75e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 260 SKGVYCLQY--DDDKIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVSSGEVLNT 335
Cdd:COG2319  246 SGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 336 LIHHNEAVLHLRFC--NGLMVTCSKDRSIAVWDMASATdisLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTS 411
Cdd:COG2319  326 LTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGE---LLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWDLA 402


                 .
gi 528499110 412 T 412
Cdd:COG2319  403 T 403
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 136-186 9.82e-31

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 113.46  E-value: 9.82e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528499110 136 QRDFITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKK 186
Cdd:cd22183    1 QRDFITALPAKGLDHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 134-193 2.12e-29

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 110.16  E-value: 2.12e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 134 MLQRDFITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKLIERMVR 193
Cdd:cd22182    1 MLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 136-186 3.17e-29

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 109.48  E-value: 3.17e-29
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528499110 136 QRDFITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKK 186
Cdd:cd22130    1 QRDFISALPAKGLDHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 98-136 3.04e-24

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 95.13  E-value: 3.04e-24
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528499110   98 QLFDQWSESDQVEFVEHLIARMCHYQHGHINSYLKPMLQ 136
Cdd:pfam12125   1 KYFDKWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 97-136 7.64e-21

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 85.62  E-value: 7.64e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110    97 IQLFDQWSESDQVEFVEHLIARMCHYQHGHINSYLKPMLQ 136
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
WD40 COG2319
WD40 repeat [General function prediction only];
251-329 4.44e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 4.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 251 QRIQCRSENSKGVYCLQY--DDDKIISGLRDNSIKIWDKQSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 326
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400


                 ...
gi 528499110 327 VSS 329
Cdd:COG2319  401 LAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 396-558 5.72e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.57  E-value: 5.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 396 IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD---RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVrCIRFD 472
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 473 N---KRIVSGAYDGKIKVWDLQaalDPRAPastLClrTLVEHSGRVFRLQF-DEFQIISSSHDDTILIWDfLNVSSNGQS 548
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDLR---NPKLP---LC--TMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWD-LSMSISGIN 697

                        170
                 ....*....|
gi 528499110 549 DgrSPSRTYT 558
Cdd:PLN00181 698 E--TPLHSFM 705
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 139-188 8.52e-10

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 54.24  E-value: 8.52e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 528499110 139 FITALPARgldhIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKLI 188
Cdd:cd22147    1 FLSALPVE----LSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 140-187 5.20e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.10  E-value: 5.20e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 528499110  140 ITALParglDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:pfam12937   1 LSSLP----DEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRL 44
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 126-185 1.81e-08

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 50.89  E-value: 1.81e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 126 HINSYLKPMLQRDFITALPARgldhIAENILSFLDARSLCSAELVCREWQRVISDGMLWK 185
Cdd:cd22133    4 HMMQVIEPQFQRDFISLLPKE----LALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-326 1.68e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110   289 SLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 142-187 3.59e-07

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 46.94  E-value: 3.59e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 528499110 142 ALPARGLDHIaenILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22109    4 SLRRRDALFC---VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46
WD40 pfam00400
WD domain, G-beta repeat;
291-326 6.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528499110  291 ECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 326
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
149-187 7.05e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.89  E-value: 7.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528499110   149 DHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 453-489 8.61e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 8.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 528499110   453 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 489
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 154-187 9.20e-07

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 45.68  E-value: 9.20e-07
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528499110 154 NILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22132   11 HIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
WD40 pfam00400
WD domain, G-beta repeat;
453-489 1.47e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.47e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528499110  453 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 489
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 140-187 2.15e-06

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 44.61  E-value: 2.15e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 528499110 140 ITALPARgldhIAENILSFLDARSLCSAELVCREWQRVISD-GMLWKKL 187
Cdd:cd22113    1 IELLPPE----MSLRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPH 45
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 302-454 2.95e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 302 SVLCLQ-YDERVIVTGSSDSTVRVWDVSSGEVLNTLIHHNEAVLHLRFCNG---LMVTCSKDRSIAVWDMASATDISLrr 377
Cdd:PLN00181 536 SGICWNsYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGT-- 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 378 vlVGHRAAVNVVDFDD---KYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNTIRLWDIEC 452
Cdd:PLN00181 614 --IKTKANICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSsTLVSSSTDNTLKLWDLSM 691


                 ..
gi 528499110 453 GA 454
Cdd:PLN00181 692 SI 693
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 149-179 4.73e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 43.20  E-value: 4.73e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528499110 149 DHIAENILSFLDARSLCSAELVCREWQRVIS 179
Cdd:cd09917    5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 138-179 8.81e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 42.70  E-value: 8.81e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 528499110 138 DFITALPARgldhIAENILSFLDARSLCSAELVCREWQRVIS 179
Cdd:cd22131    1 DFLKLLPLE----LSFYLLSFLDPESLLTCCLVSKQWNKVIS 38
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 139-185 8.83e-06

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 43.04  E-value: 8.83e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 528499110 139 FITALParglDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWK 185
Cdd:cd22148    1 FISLLP----EHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43
PTZ00421 PTZ00421
coronin; Provisional
 348-522 2.03e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 348 FCNGLMVTCSKDRSIAVWDMAS---ATDISLRRV-LVGHRAAVNVVDFD---DKYIVSASGDRTIKVWSTSTCEFVRTLN 420
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIPEeglTQNISDPIVhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 421 GHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHE--ELVRCIRFDNKRIV-----SGAYDGKIKVWDLQ 491
Cdd:PTZ00421 166 CHSDQITSLEWnlDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIitlgcSKSQQRQIMLWDTR 245

                        170       180       190
                 ....*....|....*....|....*....|.
gi 528499110 492 aalDPRAPASTlclrTLVEHSGRVFRLQFDE 522
Cdd:PTZ00421 246 ---KMASPYST----VDLDQSSALFIPFFDE 269
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 412-449 2.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.17e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110   412 TCEFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 449
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
 146-180 2.56e-05

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 41.71  E-value: 2.56e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 528499110 146 RGLDHIAENILSFLDARSLCSAELVCREWQRVISD 180
Cdd:cd22086    6 RNCPHILSKILSYLSPEDLCRVSCVSKTWRQICLS 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
311-444 2.78e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 2.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 311 RVIVTGSSDSTVRVWDVSSGEVLNTlIHHNEAVLHLRFC---NGLMVTCSKDRSIAVWDMASATdiSLRRVLVGHRAAVN 387
Cdd:COG3391   81 RLYVANSGSGRVSVIDLATGKVVAT-IPVGGGPRGLAVDpdgGRLYVADSGNGRVSVIDTATGK--VVATIPVGAGPHGI 157

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528499110 388 VVDFDDKYI-VSASGDRTI----KVWSTSTCEFVRTLN--GHKRGIACLQYRDRLVVSGSSDNT 444
Cdd:COG3391  158 AVDPDGKRLyVANSGSNTVsvivSVIDTATGKVVATIPvgGGPVGVAVSPDGRRLYVANRGSNT 221
WD40 pfam00400
WD domain, G-beta repeat;
414-449 3.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528499110  414 EFVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWD 449
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-409 3.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 528499110   374 SLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 409
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 155-187 4.79e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 40.69  E-value: 4.79e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22139   12 IFSFLSPKDLCQVALVCRRFNRLASDESLWKQI 44
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 149-187 1.01e-04

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 40.10  E-value: 1.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 528499110 149 DHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22091    6 DEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 140-187 1.10e-04

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 39.95  E-value: 1.10e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 528499110 140 ITALParglDHIAENILSFLDARSLC-SAELVCREWQRVISDGM--LWKKL 187
Cdd:cd22095    2 IQQLP----EELLRNIFAFLPAEDLYqNISLVCRHWRDIVSDPLfiPWKKL 48
WD40 pfam00400
WD domain, G-beta repeat;
374-409 1.23e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528499110  374 SLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 409
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 149-184 1.40e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 39.61  E-value: 1.40e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 528499110 149 DHIAENILSFLDARSLCSAELVCREWQRVISDGMLW 184
Cdd:cd22151    5 DDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLW 40
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 155-187 1.90e-04

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 39.14  E-value: 1.90e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22117   12 ILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 149-186 3.37e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 3.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 528499110  149 DHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKK 186
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 329-366 3.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528499110   329 SGEVLNTLIHHNEAVLHLRFC--NGLMVTCSKDRSIAVWD 366
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 154-187 3.85e-04

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 38.43  E-value: 3.85e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 528499110 154 NILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22087   11 RILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFL 44
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 138-185 4.10e-04

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 38.20  E-value: 4.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 528499110 138 DFITALPARgldhIAENILSFLDARSLCSAELVCREWQRVISDGMLWK 185
Cdd:cd22094    1 DFTRVLPRF----LSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWL 44
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 155-185 5.74e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 37.71  E-value: 5.74e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWK 185
Cdd:cd22123   12 ILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
359-487 6.29e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 6.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 359 DRSIAVWDMASATDISLRRVLVGHRAAVNVVDFDDKYI-VSASGDRTIKVWSTSTCEFVRTLN--GHKRGIACLQYRDRL 435
Cdd:COG3391   45 VGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPvgGGPRGLAVDPDGGRL 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 528499110 436 VVSGSSDNTIRLWDIECGACLRVLEGHEElVRCIRF--DNKRI-VSGAYDGKIKV 487
Cdd:COG3391  125 YVADSGNGRVSVIDTATGKVVATIPVGAG-PHGIAVdpDGKRLyVANSGSNTVSV 178
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 155-187 7.91e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 37.36  E-value: 7.91e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22137   11 IFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNL 43
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 155-187 9.14e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 37.23  E-value: 9.14e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWKKL 187
Cdd:cd22093   12 ILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 154-184 1.08e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 36.93  E-value: 1.08e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528499110 154 NILSFLDARSLCSAELVCREWQRVISDGMLW 184
Cdd:cd22118   11 KIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 139-190 1.62e-03

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 36.82  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528499110 139 FITALPARGLDHIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKLIER 190
Cdd:cd22089    2 HISALPSEILLYILRWVVSDLDLRSLEQLSLVCRKFYLLARDPSIWRLACER 53
PTZ00421 PTZ00421
coronin; Provisional
 268-374 1.62e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528499110 268 YDDDKIISGLRDNSIKIWD------KQS-LECLKVLTGHTGSVLCLQYD---ERVIVTGSSDSTVRVWDVSSGEVLNTLI 337
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGipeeglTQNiSDPIVHLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIK 165

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 528499110 338 HHNEAVLHLRFC--NGLMVTCSKDRSIAVWDMASATDIS 374
Cdd:PTZ00421 166 CHSDQITSLEWNldGSLLCTTSKDKKLNIIDPRDGTIVS 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 504-538 1.63e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528499110   504 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 149-180 2.24e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.90  E-value: 2.24e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 528499110 149 DHIAENILSFLDARSLCSAELVCREWQRVISD 180
Cdd:cd22157    5 DDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 138-184 2.37e-03

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 36.23  E-value: 2.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 528499110 138 DFITALPArgldHIAENILSFLDARSLCSAELVCREWQRVISDGMLW 184
Cdd:cd22173    1 DFTTVLPR----FLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLW 43
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 149-180 3.44e-03

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 35.39  E-value: 3.44e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 528499110 149 DHIAENILSFLD-ARSLCSAELVCREWQRVISD 180
Cdd:cd22110    6 EEILEYILSYLSpYGDLKSAALVCKRWHRIIKG 38
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 278-333 4.10e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 39.54  E-value: 4.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528499110 278 RDNSIKIWDKQSLECLKVLTGH--TGSVLCLQYDERVIVTGSSDSTVRVWDVSSGEVL 333
Cdd:cd22850  255 DLALIDIRTGKLLGRLLGKYGGsiTGAVRHPELFDPYLASGGLDRYLRVFDIETRELL 312
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 140-188 5.15e-03

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 35.23  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 528499110 140 ITALPARgldhIAENILSFLDARSLCSAELVCREWQRVISDGMLWKKLI 188
Cdd:cd22141    1 IGNLPFE----ISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLL 45
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 140-191 6.24e-03

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 36.11  E-value: 6.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 528499110 140 ITALParglDHIAENILSFLDARSL-CSAELVCREWQRVISDGMLWKKLIERM 191
Cdd:cd22168    4 ISDLP----EDVLLEILSLVPARDLiLSCRLVCSRWRDLVDLPTLWKRKCQRE 52
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 141-179 6.76e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 34.57  E-value: 6.76e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 528499110 141 TALPARGLdhiaENILSFLDARSLCSAELVCREWQRVIS 179
Cdd:cd22111    2 ARLPSRVL----EVIFSYLDLPDLRNCSLVCKSWYRLLN 36
WD40 pfam00400
WD domain, G-beta repeat;
504-538 6.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 528499110  504 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 538
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 155-185 8.75e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 34.61  E-value: 8.75e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 528499110 155 ILSFLDARSLCSAELVCREWQRVISDGMLWK 185
Cdd:cd22138   12 IFSFLSEVDKCLAATVCRSWSELIRSPRLWR 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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