|
Name |
Accession |
Description |
Interval |
E-value |
| Period_C |
pfam12114 |
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ... |
1160-1323 |
1.70e-66 |
|
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.
:
Pssm-ID: 463464 Cd Length: 171 Bit Score: 221.89 E-value: 1.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1160 NQDALSTSSDMLDLLLQEDSRSGTGSSGSGSGSGSFASG----SNGCSTS---GSGTRSSNTSKYFGSIDSSENDQNHKP 1232
Cdd:pfam12114 1 NSDALSTSSDLLDLLLQEDGCSGTGSALSGSGSSATSGSlgsgSNGCDTSgsgTGSSDTSHSSKYFGSIDSSENNHKAKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1233 ASGDLGGEQFIKFVLQDPIWLLMANTDDKIMMTYQIPIKDKDSVLKEDRDALKAAQKHQPHFTEEQKKELTQVHPWIQTG 1312
Cdd:pfam12114 81 TAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQKGELAEVHPWIQKG 160
|
170
....*....|.
gi 528492110 1313 CLPKAINVTSC 1323
Cdd:pfam12114 161 GLPAALDLSEC 171
|
|
| PAS_11 super family |
cl37882 |
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ... |
369-470 |
9.13e-12 |
|
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).
The actual alignment was detected with superfamily member pfam14598:
Pssm-ID: 464214 [Multi-domain] Cd Length: 110 Bit Score: 63.08 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 369 FTTSHTPNCLFQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQFAGQPFdhSPL-RMRARSGEYLTID 447
Cdd:pfam14598 4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGRAT--SPSyRLRLRDGDFLSVH 81
|
90 100
....*....|....*....|...
gi 528492110 448 TSWSSFINPWSRKVAFIVGRHKV 470
Cdd:pfam14598 82 TKSKLFLNQNSNQQPFIMCTHTI 104
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
739-1079 |
1.80e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 739 EPPTTPTA-STSAPATSVASPIPVNPQPMPSPTAAVHEKEKEKERRSGGSAGKGLTKAVL------SAHTQQEEQAFLNR 811
Cdd:PHA03247 2681 QRPRRRAArPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppavpaGPATPGGPARPARP 2760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 812 FRDLSQLRMVQPSG--LPPPRRCTSIPGTKGVNSSQNYPSVGNTSsrrhgrggkrqkhqvdgNIPNNTPISASGPYRGPN 889
Cdd:PHA03247 2761 PTTAGPPAPAPPAApaAGPPRRLTRPAVASLSESRESLPSPWDPA-----------------DPPAAVLAPAAALPPAAS 2823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 890 PAQIRPNFPSVQQSSNSwAPSAASQTNGAPVGTSFPPSYMTMFPTSSPfsvtqmgtDPSLQTGVPRFPAQGF--PSVMPP 967
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPP-PPPGPPPPSLPLGGSVAPGGDVRRRPPSRS--------PAAKPAAPARPPVRRLarPAVSRS 2894
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 968 VMTFMMPNYMFPQLSNPGSQlNPANSQLNAQMNSFGQFPPPVVQMSVPMFNP---AMGQFYPLGSQMNPAMPAMIPQQFY 1044
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAP-PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVA 2973
|
330 340 350
....*....|....*....|....*....|....*...
gi 528492110 1045 NPNYQLNfSNSPSMPAANVSTTP---HGQSRSSTPQST 1079
Cdd:PHA03247 2974 VPRFRVP-QPAPSREAPASSTPPltgHSLSRVSSWASS 3010
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Period_C |
pfam12114 |
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ... |
1160-1323 |
1.70e-66 |
|
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.
Pssm-ID: 463464 Cd Length: 171 Bit Score: 221.89 E-value: 1.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1160 NQDALSTSSDMLDLLLQEDSRSGTGSSGSGSGSGSFASG----SNGCSTS---GSGTRSSNTSKYFGSIDSSENDQNHKP 1232
Cdd:pfam12114 1 NSDALSTSSDLLDLLLQEDGCSGTGSALSGSGSSATSGSlgsgSNGCDTSgsgTGSSDTSHSSKYFGSIDSSENNHKAKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1233 ASGDLGGEQFIKFVLQDPIWLLMANTDDKIMMTYQIPIKDKDSVLKEDRDALKAAQKHQPHFTEEQKKELTQVHPWIQTG 1312
Cdd:pfam12114 81 TAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQKGELAEVHPWIQKG 160
|
170
....*....|.
gi 528492110 1313 CLPKAINVTSC 1323
Cdd:pfam12114 161 GLPAALDLSEC 171
|
|
| PAS_11 |
pfam14598 |
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ... |
369-470 |
9.13e-12 |
|
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).
Pssm-ID: 464214 [Multi-domain] Cd Length: 110 Bit Score: 63.08 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 369 FTTSHTPNCLFQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQFAGQPFdhSPL-RMRARSGEYLTID 447
Cdd:pfam14598 4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGRAT--SPSyRLRLRDGDFLSVH 81
|
90 100
....*....|....*....|...
gi 528492110 448 TSWSSFINPWSRKVAFIVGRHKV 470
Cdd:pfam14598 82 TKSKLFLNQNSNQQPFIMCTHTI 104
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
369-470 |
1.08e-10 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 59.95 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 369 FTTSHTPNCLFQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQfAGQPFDHsPLRMRARSGEYLTIDT 448
Cdd:cd00130 4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTL-EVRLRRKDGSVIWVLV 81
|
90 100
....*....|....*....|..
gi 528492110 449 SWSSFINPWSRKVAFIVGRHKV 470
Cdd:cd00130 82 SLTPIRDEGGEVIGLLGVVRDI 103
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
368-423 |
2.41e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 46.24 E-value: 2.41e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 528492110 368 IFTTSHTPNCLFqeIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQ 423
Cdd:smart00091 14 IFVLDLDGRILY--ANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
739-1079 |
1.80e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 739 EPPTTPTA-STSAPATSVASPIPVNPQPMPSPTAAVHEKEKEKERRSGGSAGKGLTKAVL------SAHTQQEEQAFLNR 811
Cdd:PHA03247 2681 QRPRRRAArPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppavpaGPATPGGPARPARP 2760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 812 FRDLSQLRMVQPSG--LPPPRRCTSIPGTKGVNSSQNYPSVGNTSsrrhgrggkrqkhqvdgNIPNNTPISASGPYRGPN 889
Cdd:PHA03247 2761 PTTAGPPAPAPPAApaAGPPRRLTRPAVASLSESRESLPSPWDPA-----------------DPPAAVLAPAAALPPAAS 2823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 890 PAQIRPNFPSVQQSSNSwAPSAASQTNGAPVGTSFPPSYMTMFPTSSPfsvtqmgtDPSLQTGVPRFPAQGF--PSVMPP 967
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPP-PPPGPPPPSLPLGGSVAPGGDVRRRPPSRS--------PAAKPAAPARPPVRRLarPAVSRS 2894
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 968 VMTFMMPNYMFPQLSNPGSQlNPANSQLNAQMNSFGQFPPPVVQMSVPMFNP---AMGQFYPLGSQMNPAMPAMIPQQFY 1044
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAP-PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVA 2973
|
330 340 350
....*....|....*....|....*....|....*...
gi 528492110 1045 NPNYQLNfSNSPSMPAANVSTTP---HGQSRSSTPQST 1079
Cdd:PHA03247 2974 VPRFRVP-QPAPSREAPASSTPPltgHSLSRVSSWASS 3010
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
740-1101 |
1.98e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.91 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 740 PPTTPTASTSAPATSVASPIPVNPQPMPSPTAAVHEKEkekerrsggsagkglTKAVLSAHTQQEEQAFLNRFRDLSQLR 819
Cdd:pfam03154 183 PPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ---------------TQSTAAPHTLIQQTPTLHPQRLPSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 820 MVQPSGLPPPrrctsipgtKGVNSSQNYPSvgntsSRRHGRGGkrqkhqvdgniPNNTPISaSGPYRGPNPAQIRPnFPS 899
Cdd:pfam03154 248 PLQPMTQPPP---------PSQVSPQPLPQ-----PSLHGQMP-----------PMPHSLQ-TGPSHMQHPVPPQP-FPL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 900 VQQSSNSWAPSaasqtnGAPVGTSFPPSYMTMFPTSSPFSVTQmgtDPSLQTGVPRFPaQGFPSVMPPvmtfmmPNYMFP 979
Cdd:pfam03154 301 TPQSSQSQVPP------GPSPAAPGQSQQRIHTPPSQSQLQSQ---QPPREQPLPPAP-LSMPHIKPP------PTTPIP 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 980 QLSNPGSQLNPANSQLNA--QMNSFGQFPPPVVQMSV------PMFNPAMGQFYPLGSQMnPAMPAMIPqqfynpnyqlN 1051
Cdd:pfam03154 365 QLPNPQSHKHPPHLSGPSpfQMNSNLPPPPALKPLSSlsthhpPSAHPPPLQLMPQSQQL-PPPPAQPP----------V 433
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 528492110 1052 FSNSPSMPAANVSTTPHGQSRSSTPQSTGPQAGERDGAGSPLFQSRCSSP 1101
Cdd:pfam03154 434 LTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPT 483
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
379-466 |
4.38e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.78 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 379 FQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQFAGQPFDhspLRMRARSGEYLTIDTSWSSFINPWS 458
Cdd:COG2202 159 ILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYE---LELRLKDGDGRWVWVEASAVPLRDG 235
|
....*...
gi 528492110 459 RKVAFIVG 466
Cdd:COG2202 236 GEVIGVLG 243
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Period_C |
pfam12114 |
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ... |
1160-1323 |
1.70e-66 |
|
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.
Pssm-ID: 463464 Cd Length: 171 Bit Score: 221.89 E-value: 1.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1160 NQDALSTSSDMLDLLLQEDSRSGTGSSGSGSGSGSFASG----SNGCSTS---GSGTRSSNTSKYFGSIDSSENDQNHKP 1232
Cdd:pfam12114 1 NSDALSTSSDLLDLLLQEDGCSGTGSALSGSGSSATSGSlgsgSNGCDTSgsgTGSSDTSHSSKYFGSIDSSENNHKAKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 1233 ASGDLGGEQFIKFVLQDPIWLLMANTDDKIMMTYQIPIKDKDSVLKEDRDALKAAQKHQPHFTEEQKKELTQVHPWIQTG 1312
Cdd:pfam12114 81 TAEVGEEEHFIKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQKGELAEVHPWIQKG 160
|
170
....*....|.
gi 528492110 1313 CLPKAINVTSC 1323
Cdd:pfam12114 161 GLPAALDLSEC 171
|
|
| PAS_11 |
pfam14598 |
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ... |
369-470 |
9.13e-12 |
|
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).
Pssm-ID: 464214 [Multi-domain] Cd Length: 110 Bit Score: 63.08 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 369 FTTSHTPNCLFQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQFAGQPFdhSPL-RMRARSGEYLTID 447
Cdd:pfam14598 4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGRAT--SPSyRLRLRDGDFLSVH 81
|
90 100
....*....|....*....|...
gi 528492110 448 TSWSSFINPWSRKVAFIVGRHKV 470
Cdd:pfam14598 82 TKSKLFLNQNSNQQPFIMCTHTI 104
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
369-470 |
1.08e-10 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 59.95 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 369 FTTSHTPNCLFQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQfAGQPFDHsPLRMRARSGEYLTIDT 448
Cdd:cd00130 4 GVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLS-GGEPVTL-EVRLRRKDGSVIWVLV 81
|
90 100
....*....|....*....|..
gi 528492110 449 SWSSFINPWSRKVAFIVGRHKV 470
Cdd:cd00130 82 SLTPIRDEGGEVIGLLGVVRDI 103
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
382-466 |
1.08e-10 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 59.27 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 382 IDERAVPLLGYLPQDLVGKPVLVY--LHPEDRLLMVAIHKKILQfAGQPFDHsPLRMRARSGEYLTIDTSWSSFINpWSR 459
Cdd:pfam08447 4 WSPRFEEILGYTPEELLGKGESWLdlVHPDDRERVREALWEALK-GGEPYSG-EYRIRRKDGEYRWVEARARPIRD-ENG 80
|
....*..
gi 528492110 460 KVAFIVG 466
Cdd:pfam08447 81 KPVRVIG 87
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
368-423 |
2.41e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 46.24 E-value: 2.41e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 528492110 368 IFTTSHTPNCLFqeIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQ 423
Cdd:smart00091 14 IFVLDLDGRILY--ANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
368-465 |
7.36e-06 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 46.26 E-value: 7.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 368 IFTTSHTPNCLFqeIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQfAGQPFDHSPLRMRARSGEYLTID 447
Cdd:pfam00989 14 IFVVDEDGRILY--VNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALL-QGEESRGFEVSFRVPDGRPRHVE 90
|
90
....*....|....*...
gi 528492110 448 TSWSSFINPWSRKVAFIV 465
Cdd:pfam00989 91 VRASPVRDAGGEILGFLG 108
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
739-1079 |
1.80e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 739 EPPTTPTA-STSAPATSVASPIPVNPQPMPSPTAAVHEKEKEKERRSGGSAGKGLTKAVL------SAHTQQEEQAFLNR 811
Cdd:PHA03247 2681 QRPRRRAArPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppavpaGPATPGGPARPARP 2760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 812 FRDLSQLRMVQPSG--LPPPRRCTSIPGTKGVNSSQNYPSVGNTSsrrhgrggkrqkhqvdgNIPNNTPISASGPYRGPN 889
Cdd:PHA03247 2761 PTTAGPPAPAPPAApaAGPPRRLTRPAVASLSESRESLPSPWDPA-----------------DPPAAVLAPAAALPPAAS 2823
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 890 PAQIRPNFPSVQQSSNSwAPSAASQTNGAPVGTSFPPSYMTMFPTSSPfsvtqmgtDPSLQTGVPRFPAQGF--PSVMPP 967
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPP-PPPGPPPPSLPLGGSVAPGGDVRRRPPSRS--------PAAKPAAPARPPVRRLarPAVSRS 2894
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 968 VMTFMMPNYMFPQLSNPGSQlNPANSQLNAQMNSFGQFPPPVVQMSVPMFNP---AMGQFYPLGSQMNPAMPAMIPQQFY 1044
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAP-PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLGALVPGRVA 2973
|
330 340 350
....*....|....*....|....*....|....*...
gi 528492110 1045 NPNYQLNfSNSPSMPAANVSTTP---HGQSRSSTPQST 1079
Cdd:PHA03247 2974 VPRFRVP-QPAPSREAPASSTPPltgHSLSRVSSWASS 3010
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
740-1101 |
1.98e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.91 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 740 PPTTPTASTSAPATSVASPIPVNPQPMPSPTAAVHEKEkekerrsggsagkglTKAVLSAHTQQEEQAFLNRFRDLSQLR 819
Cdd:pfam03154 183 PPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ---------------TQSTAAPHTLIQQTPTLHPQRLPSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 820 MVQPSGLPPPrrctsipgtKGVNSSQNYPSvgntsSRRHGRGGkrqkhqvdgniPNNTPISaSGPYRGPNPAQIRPnFPS 899
Cdd:pfam03154 248 PLQPMTQPPP---------PSQVSPQPLPQ-----PSLHGQMP-----------PMPHSLQ-TGPSHMQHPVPPQP-FPL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 900 VQQSSNSWAPSaasqtnGAPVGTSFPPSYMTMFPTSSPFSVTQmgtDPSLQTGVPRFPaQGFPSVMPPvmtfmmPNYMFP 979
Cdd:pfam03154 301 TPQSSQSQVPP------GPSPAAPGQSQQRIHTPPSQSQLQSQ---QPPREQPLPPAP-LSMPHIKPP------PTTPIP 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 980 QLSNPGSQLNPANSQLNA--QMNSFGQFPPPVVQMSV------PMFNPAMGQFYPLGSQMnPAMPAMIPqqfynpnyqlN 1051
Cdd:pfam03154 365 QLPNPQSHKHPPHLSGPSpfQMNSNLPPPPALKPLSSlsthhpPSAHPPPLQLMPQSQQL-PPPPAQPP----------V 433
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 528492110 1052 FSNSPSMPAANVSTTPHGQSRSSTPQSTGPQAGERDGAGSPLFQSRCSSP 1101
Cdd:pfam03154 434 LTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPT 483
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
685-1140 |
2.54e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.36 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 685 SKVVPAAPAHPLTPLALHCKAESVVSATSQCSFSSTIVHVGDKKPPESDIVMME--EPPTTPTASTSAPA-TSVASPIPV 761
Cdd:PHA03378 522 ATLLPPSPPQPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPGLGPLQIQplTSPTTSQLASSAPSyAQTPWPVPH 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 762 NPQPMPSPTAAVHEKEKEKERRSGgsagkgLTKAVLSAHTQQEEQAFLNR--FRDLSQLRMVQPSGLPP----PRRCTSI 835
Cdd:PHA03378 602 PSQTPEPPTTQSHIPETSAPRQWP------MPLRPIPMRPLRMQPITFNVlvFPTPHQPPQVEITPYKPtwtqIGHIPYQ 675
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 836 PGTKGVNSS---QNYPSVGNTSSRRHGRGGKRQKHQVDGNIPNNTPISASGPYRGPNPAQiRPNFPSVQQSSNSWAPSAA 912
Cdd:PHA03378 676 PSPTGANTMlpiQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRAR-PPAAAPGRARPPAAAPGRA 754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 913 SQTNGAPvGTSFPPSYMTMFPTSSPfsvtqmgtdPSLQTGVPRFPAQGFPSVMPPVMTfmMPNYMFPQLSNPGSQLNPAN 992
Cdd:PHA03378 755 RPPAAAP-GRARPPAAAPGAPTPQP---------PPQAPPAPQQRPRGAPTPQPPPQA--GPTSMQLMPRAAPGQQGPTK 822
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 993 SQLNAQMNSFGQFPPPVVQmsvpmFNPAMGQFYPLGSQMNP--AMPAMIPQQ--FYNPNYQlnfsnsPS-MPAANVSTTP 1067
Cdd:PHA03378 823 QILRQLLTGGVKRGRPSLK-----KPAALERQAAAGPTPSPgsGTSDKIVQApvFYPPVLQ------PIqVMRQLGSVRA 891
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528492110 1068 HGQSrsSTPQSTGPQAGERDGAGSplfqsrcSSPLNLLqleelPSNR--TDATQQTPPPGGGATQGGVVVVQNSS 1140
Cdd:PHA03378 892 AAAS--TVTQAPTEYTGERRGVGP-------MHPTDIP-----PSKRakTDAYVESQPPHGGQSHSFSVIWENVS 952
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
379-466 |
4.38e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.78 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 379 FQEIDERAVPLLGYLPQDLVGKPVLVYLHPEDRLLMVAIHKKILQFAGQPFDhspLRMRARSGEYLTIDTSWSSFINPWS 458
Cdd:COG2202 159 ILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYE---LELRLKDGDGRWVWVEASAVPLRDG 235
|
....*...
gi 528492110 459 RKVAFIVG 466
Cdd:COG2202 236 GEVIGVLG 243
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
680-937 |
4.47e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.45 E-value: 4.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 680 VVTEGSKVVPAAPAHPLTPLALHCKAESVVSATSQCSFSSTIVHVgDKKPPESDIvmmeepPTTPTAST--SAPATSVAS 757
Cdd:PLN03209 334 DAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYE-DLKPPTSPI------PTPPSSSPasSKSVDAVAK 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 758 PIPVNPQPMPSPTAAVHEK-----EKEKERRsggsagkgltkavLSAHTqqeeqaflnRFRDLSQlrMVQPSGLPPPRRC 832
Cdd:PLN03209 407 PAEPDVVPSPGSASNVPEVepaqvEAKKTRP-------------LSPYA---------RYEDLKP--PTSPSPTAPTGVS 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492110 833 TSIPGTKGVNSSQNYP---SVGNTSSRRHGRGGKRQKHQVDGNIPNNTPISASGPYRGPNPAQIRPNFPSVQQSSNSWAP 909
Cdd:PLN03209 463 PSVSSTSSVPAVPDTApatAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
|
250 260
....*....|....*....|....*...
gi 528492110 910 SAASQTNGAPVGTSFPPSYMTMFPTSSP 937
Cdd:PLN03209 543 DEQHHAQPKPRPLSPYTMYEDLKPPTSP 570
|
|
| |
