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Conserved domains on  [gi|124805940|ref|XP_001350582|]
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thrombospondin-related apical membrane protein [Plasmodium falciparum 3D7]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10015197)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 11-352 0e+00

thrombosponding-related protein; Provisional


:

Pssm-ID: 185438  Cd Length: 340  Bit Score: 637.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  11 YLYFTFLLFLYISSNDLCSCNLKVRNNWEHFLQVYQNNGNFKMEILEPECTIQKNLPSEEEKEEfIDFDRKELLLHDFVV 90
Cdd:PTZ00087   1 MRSFTFLAVLLITICYQCISNLFKRQNTNYFLQLLQKNGNYKIVTLEPECTVGKGLQLGQAKQE-SDVNRKEFLLHNYVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  91 IKNSQFTDEKTLELYLSKEENNKSYLMLTFYLGDLKLMIGHNSPYEISLILNVATVNKNmSNCKNNSYNIVLLKTTDVFN 170
Cdd:PTZ00087  80 IKNSQFTNEKTLELYSSKEENNKSHLVLTFYIGDFNFSVGHNSPYEVNLILSVMAGNKK-STCKNNNYNIVLLKSADVFN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 171 TSDLEILEGPIQFSLGKSSGAFRINVTNFFLNNTWKAFTKDKISFLIKPEENCYTILENKINKPQLLIEKKTTFYSEWGE 250
Cdd:PTZ00087 159 PSELEILSEPIKFSISKTSGSFRININNFFLDGTWRAFVKDRLTFLLKPEDNCYTVLENKLNKPSLIIEKKNMFYTEWGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 251 WSNCSMDCDHPDNVQIRERECIHPSGDCFKGDLKESRPCIIPLPPCNELFSHKDNSTFKILMIILPIVLVISIITILYHI 330
Cdd:PTZ00087 239 WSNCSMECDHPDNVQIRERKCAHPSGDCFKGDLKETRPCQVPLPPCNSLFEHKESSTFKILIILLPIVLIICVMGILYHI 318

                        330       340
                 ....*....|....*....|..
gi 124805940 331 FYKRKGAEKELYENVAGRYMYD 352
Cdd:PTZ00087 319 FYKKKGAEKELYENVAGRFMYD 340
 
Name Accession Description Interval E-value
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 11-352 0e+00

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 637.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  11 YLYFTFLLFLYISSNDLCSCNLKVRNNWEHFLQVYQNNGNFKMEILEPECTIQKNLPSEEEKEEfIDFDRKELLLHDFVV 90
Cdd:PTZ00087   1 MRSFTFLAVLLITICYQCISNLFKRQNTNYFLQLLQKNGNYKIVTLEPECTVGKGLQLGQAKQE-SDVNRKEFLLHNYVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  91 IKNSQFTDEKTLELYLSKEENNKSYLMLTFYLGDLKLMIGHNSPYEISLILNVATVNKNmSNCKNNSYNIVLLKTTDVFN 170
Cdd:PTZ00087  80 IKNSQFTNEKTLELYSSKEENNKSHLVLTFYIGDFNFSVGHNSPYEVNLILSVMAGNKK-STCKNNNYNIVLLKSADVFN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 171 TSDLEILEGPIQFSLGKSSGAFRINVTNFFLNNTWKAFTKDKISFLIKPEENCYTILENKINKPQLLIEKKTTFYSEWGE 250
Cdd:PTZ00087 159 PSELEILSEPIKFSISKTSGSFRININNFFLDGTWRAFVKDRLTFLLKPEDNCYTVLENKLNKPSLIIEKKNMFYTEWGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 251 WSNCSMDCDHPDNVQIRERECIHPSGDCFKGDLKESRPCIIPLPPCNELFSHKDNSTFKILMIILPIVLVISIITILYHI 330
Cdd:PTZ00087 239 WSNCSMECDHPDNVQIRERKCAHPSGDCFKGDLKETRPCQVPLPPCNSLFEHKESSTFKILIILLPIVLIICVMGILYHI 318

                        330       340
                 ....*....|....*....|..
gi 124805940 331 FYKRKGAEKELYENVAGRYMYD 352
Cdd:PTZ00087 319 FYKKKGAEKELYENVAGRFMYD 340
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 246-296 4.75e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 4.75e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124805940   246 SEWGEWSNCSMDCDhpDNVQIRERECI-----HPSGDCfKGDLKESRPCiiPLPPC 296
Cdd:smart00209   2 SEWSEWSPCSVTCG--GGVQTRTRSCCspppqNGGGPC-TGEDVETRAC--NEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 245-296 6.48e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 6.48e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124805940  245 YSEWGEWSNCSMDCDhpDNVQIRERECI-HPSGD---CfkGDLKESRPCIipLPPC 296
Cdd:pfam19028   3 VSEWSEWSECSVTCG--GGVQTRTRTVIvEPQNGgrpC--PELLERRPCN--LPPC 52
 
Name Accession Description Interval E-value
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 11-352 0e+00

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 637.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  11 YLYFTFLLFLYISSNDLCSCNLKVRNNWEHFLQVYQNNGNFKMEILEPECTIQKNLPSEEEKEEfIDFDRKELLLHDFVV 90
Cdd:PTZ00087   1 MRSFTFLAVLLITICYQCISNLFKRQNTNYFLQLLQKNGNYKIVTLEPECTVGKGLQLGQAKQE-SDVNRKEFLLHNYVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940  91 IKNSQFTDEKTLELYLSKEENNKSYLMLTFYLGDLKLMIGHNSPYEISLILNVATVNKNmSNCKNNSYNIVLLKTTDVFN 170
Cdd:PTZ00087  80 IKNSQFTNEKTLELYSSKEENNKSHLVLTFYIGDFNFSVGHNSPYEVNLILSVMAGNKK-STCKNNNYNIVLLKSADVFN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 171 TSDLEILEGPIQFSLGKSSGAFRINVTNFFLNNTWKAFTKDKISFLIKPEENCYTILENKINKPQLLIEKKTTFYSEWGE 250
Cdd:PTZ00087 159 PSELEILSEPIKFSISKTSGSFRININNFFLDGTWRAFVKDRLTFLLKPEDNCYTVLENKLNKPSLIIEKKNMFYTEWGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805940 251 WSNCSMDCDHPDNVQIRERECIHPSGDCFKGDLKESRPCIIPLPPCNELFSHKDNSTFKILMIILPIVLVISIITILYHI 330
Cdd:PTZ00087 239 WSNCSMECDHPDNVQIRERKCAHPSGDCFKGDLKETRPCQVPLPPCNSLFEHKESSTFKILIILLPIVLIICVMGILYHI 318

                        330       340
                 ....*....|....*....|..
gi 124805940 331 FYKRKGAEKELYENVAGRYMYD 352
Cdd:PTZ00087 319 FYKKKGAEKELYENVAGRFMYD 340
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 246-296 4.75e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 4.75e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 124805940   246 SEWGEWSNCSMDCDhpDNVQIRERECI-----HPSGDCfKGDLKESRPCiiPLPPC 296
Cdd:smart00209   2 SEWSEWSPCSVTCG--GGVQTRTRSCCspppqNGGGPC-TGEDVETRAC--NEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 245-296 6.48e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 6.48e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 124805940  245 YSEWGEWSNCSMDCDhpDNVQIRERECI-HPSGD---CfkGDLKESRPCIipLPPC 296
Cdd:pfam19028   3 VSEWSEWSECSVTCG--GGVQTRTRTVIvEPQNGgrpC--PELLERRPCN--LPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
246-296 6.81e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 45.49  E-value: 6.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 124805940  246 SEWGEWSNCSMDCDhpDNVQIRERECIHP---SGDCfKGDLKESRPCiiPLPPC 296
Cdd:pfam00090   1 SPWSPWSPCSVTCG--KGIQVRQRTCKSPfpgGEPC-TGDDIETQAC--KMDKC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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