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Conserved domains on  [gi|499483803|ref|WP_011170443|]
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winged helix-turn-helix domain-containing protein [Methanococcus maripaludis]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 20282661)

winged helix-turn-helix (wHTH) domain-containing protein with an ArsR family wHTH domain, binds DNA and may function as a transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  10679470|10908318|12829264

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 167-228 6.10e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


:

Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 6.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499483803 167 LEPISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQRSD--RGDYMIT 228
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREgrRVYYSLT 64
Lipase_GDSL_3 super family cl46856
GDSL-like Lipase/Acylhydrolase family;
81-184 2.34e-04

GDSL-like Lipase/Acylhydrolase family;


The actual alignment was detected with superfamily member PRK15381:

Pssm-ID: 481196  Cd Length: 408  Bit Score: 41.96  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499483803  81 TLLGILNNSAKNLKENKISQDKIItiRKNLENLKEKLPYEKcsVCYSETVKLFEKQIDLMKNLGIYSEN----------- 149
Cdd:PRK15381 289 TPYGKHSDEKRKLKDESIAHNALL--KTNVEELKEKYPQHK--ICYYETADAFKVIMEAASNIGYDTENpythhgyvhvp 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499483803 150 -YEKNELNVSEKEIITSLLEPISNKHR--LLILKSLMA 184
Cdd:PRK15381 365 gAKDPQLDICPQYVFNDLVHPTQEVHHcfAIMLESFIA 402
 
Name Accession Description Interval E-value
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 167-228 6.10e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 6.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499483803 167 LEPISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQRSD--RGDYMIT 228
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREgrRVYYSLT 64
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
155-233 1.62e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 42.64  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499483803 155 LNVSEKEIITSLLEPISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMI---MQRSDRGDYMITKRG 231
Cdd:COG4189    1 MVVLDDEESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIrteYKPGKRGRQKICYLR 80


                 ..
gi 499483803 232 ID 233
Cdd:COG4189   81 VD 82
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 170-222 4.10e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 40.22  E-value: 4.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 499483803  170 ISNKHRLLILKSLM-AETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQRSDR 222
Cdd:pfam12840   7 LADPTRLRILRALVgDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
178-219 1.50e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.12  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 499483803   178 ILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQR 219
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
PRK15381 PRK15381
type III secretion system effector;
81-184 2.34e-04

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 41.96  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499483803  81 TLLGILNNSAKNLKENKISQDKIItiRKNLENLKEKLPYEKcsVCYSETVKLFEKQIDLMKNLGIYSEN----------- 149
Cdd:PRK15381 289 TPYGKHSDEKRKLKDESIAHNALL--KTNVEELKEKYPQHK--ICYYETADAFKVIMEAASNIGYDTENpythhgyvhvp 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499483803 150 -YEKNELNVSEKEIITSLLEPISNKHR--LLILKSLMA 184
Cdd:PRK15381 365 gAKDPQLDICPQYVFNDLVHPTQEVHHcfAIMLESFIA 402
 
Name Accession Description Interval E-value
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 167-228 6.10e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 6.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499483803 167 LEPISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQRSD--RGDYMIT 228
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREgrRVYYSLT 64
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
155-233 1.62e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 42.64  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499483803 155 LNVSEKEIITSLLEPISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMI---MQRSDRGDYMITKRG 231
Cdd:COG4189    1 MVVLDDEESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIrteYKPGKRGRQKICYLR 80


                 ..
gi 499483803 232 ID 233
Cdd:COG4189   81 VD 82
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 170-222 4.10e-05

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 40.22  E-value: 4.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 499483803  170 ISNKHRLLILKSLM-AETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQRSDR 222
Cdd:pfam12840   7 LADPTRLRILRALVgDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
170-219 1.16e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 39.87  E-value: 1.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 499483803 170 ISNKHRLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQR 219
Cdd:COG0640   17 LADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
178-219 1.50e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 39.12  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 499483803   178 ILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMIMQR 219
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 175-216 2.28e-04

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 37.81  E-value: 2.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 499483803  175 RLLILKSLMAETKTFSDISKITGLKAGNLLFHLKKLQDSEMI 216
Cdd:pfam01022   4 RLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK15381 PRK15381
type III secretion system effector;
81-184 2.34e-04

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 41.96  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499483803  81 TLLGILNNSAKNLKENKISQDKIItiRKNLENLKEKLPYEKcsVCYSETVKLFEKQIDLMKNLGIYSEN----------- 149
Cdd:PRK15381 289 TPYGKHSDEKRKLKDESIAHNALL--KTNVEELKEKYPQHK--ICYYETADAFKVIMEAASNIGYDTENpythhgyvhvp 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 499483803 150 -YEKNELNVSEKEIITSLLEPISNKHR--LLILKSLMA 184
Cdd:PRK15381 365 gAKDPQLDICPQYVFNDLVHPTQEVHHcfAIMLESFIA 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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