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Conserved domains on  [gi|223278377|ref|NP_872325|]
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BPI fold-containing family B member 4 precursor [Homo sapiens]

Protein Classification

LBP/BPI/CETP family protein( domain architecture ID 10646337)

LBP (lipopolysaccharide-binding protein)/BPI (bactericidal permeability-increasing protein)/CETP (cholesteryl ester transfer protein) family protein similar to Homo sapiens BPI fold-containing family B member 4 and cholesteryl ester transfer protein

Gene Ontology:  GO:0008289
PubMed:  9665271|15106612

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BPI2 smart00329
BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
414-614 1.15e-53

BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain


:

Pssm-ID: 128624  Cd Length: 202  Bit Score: 181.74  E-value: 1.15e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   414 DNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPP--LTTATLGALIPKVFQQYPEScPLIIRIQVLNPPSVML 491
Cdd:smart00329   1 SDRMVYLALSEYFFNSLLFVYQQAGALKLTITDDMLPKESKflLTTCCFGTLVPEVAEQYPDS-TLQLEISVLSPPRVTL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   492 QKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKI 571
Cdd:smart00329  80 QPGGATVYIHASVKVFAILPDSSRASLFLMSVDTNVSAKSSFKTKKLLGELKLDKLQVELKHSNVGGFDAELLEDLLNYL 159
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 223278377   572 FDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:smart00329 160 VPAVLLPKVNEKLRRGVPLPLPCGVQLINPVLQVHDDFLLLGA 202
BPI1 smart00328
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
219-389 4.80e-37

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain


:

Pssm-ID: 214622 [Multi-domain]  Cd Length: 225  Bit Score: 137.52  E-value: 4.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   219 STVQGITGLRIVELTLPRVSVRLLPGVGVYLS---LYTRVAINGKSLIGFL------DIAVEVN-ITAKVRLTMDRTGYP 288
Cdd:smart00328  41 IGHYSIYSLSISRLELPSSLLRFQPSKGLRLSisnLSLRVSGDLKGSLNFIklegnfQLSVEGLsISADLRIESNASGRP 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   289 RLVIERCDTLLGGIKVKL---LRGLLPNLVDNLVNRVLADVLPDLLCPIVD-VVLGLVNDQLGLVDSLIPLGILGSVQYT 364
Cdd:smart00328 121 TVTLSSCSSSIGDVRLHFsgsVLGWLINLFRKFIENTLRNVLEDQICPVIDsAVSNKMNDYLQTLPLSISLDSLIGVDYS 200
                          170       180
                   ....*....|....*....|....*
gi 223278377   365 FSSLPLVTGEFLELDLNTLVGEAGG 389
Cdd:smart00328 201 LVSPPRVTASFLDVRLKGKFFWKNH 225
 
Name Accession Description Interval E-value
BPI2 smart00329
BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
414-614 1.15e-53

BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain


Pssm-ID: 128624  Cd Length: 202  Bit Score: 181.74  E-value: 1.15e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   414 DNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPP--LTTATLGALIPKVFQQYPEScPLIIRIQVLNPPSVML 491
Cdd:smart00329   1 SDRMVYLALSEYFFNSLLFVYQQAGALKLTITDDMLPKESKflLTTCCFGTLVPEVAEQYPDS-TLQLEISVLSPPRVTL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   492 QKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKI 571
Cdd:smart00329  80 QPGGATVYIHASVKVFAILPDSSRASLFLMSVDTNVSAKSSFKTKKLLGELKLDKLQVELKHSNVGGFDAELLEDLLNYL 159
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 223278377   572 FDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:smart00329 160 VPAVLLPKVNEKLRRGVPLPLPCGVQLINPVLQVHDDFLLLGA 202
BPI1 smart00328
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
219-389 4.80e-37

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain


Pssm-ID: 214622 [Multi-domain]  Cd Length: 225  Bit Score: 137.52  E-value: 4.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   219 STVQGITGLRIVELTLPRVSVRLLPGVGVYLS---LYTRVAINGKSLIGFL------DIAVEVN-ITAKVRLTMDRTGYP 288
Cdd:smart00328  41 IGHYSIYSLSISRLELPSSLLRFQPSKGLRLSisnLSLRVSGDLKGSLNFIklegnfQLSVEGLsISADLRIESNASGRP 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   289 RLVIERCDTLLGGIKVKL---LRGLLPNLVDNLVNRVLADVLPDLLCPIVD-VVLGLVNDQLGLVDSLIPLGILGSVQYT 364
Cdd:smart00328 121 TVTLSSCSSSIGDVRLHFsgsVLGWLINLFRKFIENTLRNVLEDQICPVIDsAVSNKMNDYLQTLPLSISLDSLIGVDYS 200
                          170       180
                   ....*....|....*....|....*
gi 223278377   365 FSSLPLVTGEFLELDLNTLVGEAGG 389
Cdd:smart00328 201 LVSPPRVTASFLDVRLKGKFFWKNH 225
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
219-340 4.09e-26

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 104.69  E-value: 4.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  219 STVQGITGLRIVELTLPRVSVRLLPGVGV-YLSLYTRVAINGKS--LIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERC 295
Cdd:pfam01273  36 KVLYNITNLKISNLQLPNLQLEFSPGGGLlLLIIPLTLKVSGKWplRGSFLELVVGVDITASLRLERDPQGRPTLVLSDC 115
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 223278377  296 DTLLGGIKVKLLRGL--LPNLVDNLVNRVLADVLPDLLCPIVDVVLG 340
Cdd:pfam01273 116 SSSPGSISISLLGGLgwLLDLLTNLLESTLPKVLQSQLCPVIQSVLS 162
BPI2 cd00026
BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
420-614 1.50e-23

BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 237993  Cd Length: 200  Bit Score: 98.53  E-value: 1.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 420 LAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPEScPLIIRIQVLNPPSVMLQKDKALVK 499
Cdd:cd00026    4 LAVSEHVFNSAALVYFQAGALNLLLTDDMPPSKSRLTTSIFGIFIPELAKKYPNM-PQQLKISVSSPPHLVLSEGGATLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 500 VLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPA 579
Cdd:cd00026   83 QQLDVEIFATLPDSQLRPLFRLGVDTSSSAQLSVSKKKLIGSLNLDRFLLELKSSNIGSFIPELLQAILTTILEITVLPN 162
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 223278377 580 MNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:cd00026  163 VNDKLRRGFPLPLPKNFTLYDAEIQVHKDFLLLGA 197
BPI1 cd00025
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
221-384 1.57e-21

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 237992  Cd Length: 223  Bit Score: 93.59  E-value: 1.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 221 VQGITGLRIVELTLPRVSVRLLPGVGVYLSLyTRVAINGK----------SLIGFLDIAVE-VNITAKVRLTMDRTGYPR 289
Cdd:cd00025   47 RVGLSNKEIQELKLPSSSIKLVEVKGLDLSI-SNVSIGLSgvwkynyrfiLDGGNVELSVEgMNIQADLRLGRDPSGRPK 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 290 LVIERCDTLLGGIKVKLL--RGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSS 367
Cdd:cd00025  126 LSLSDCSSTVGSLRVHLGgsLGWLAKLFMNFIESLLKKVLKGQLCPVIDASLVSMLESLLQLPKLPPVDSNAGVDYSLTS 205
                        170
                 ....*....|....*..
gi 223278377 368 LPLVTGEFLELDLNTLV 384
Cdd:cd00025  206 PPVLTASYLDSDIKGTF 222
LBP_BPI_CETP_C pfam02886
LBP / BPI / CETP family, C-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
394-614 5.40e-20

LBP / BPI / CETP family, C-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 397154  Cd Length: 238  Bit Score: 89.34  E-value: 5.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  394 YPLG--WPAVSPKPMPELPPMGDNTkSQLAMSANFLGSVLTLLQKQHALDLDITNGMfeeLPP-----LTTATLGALIPK 466
Cdd:pfam02886  12 FPLNhrSPVRFPPPVMALPEEHDRM-VYFAISDYFFNSALYVYHRAGFLKVTLTDDM---IPKdsdlrLTTKCFGPFLPL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  467 VFQQYPEScPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEK 546
Cdd:pfam02886  88 LAEQYPNM-TLELEGSALSPPLLNFSPGGLTISPNASLNAFVVLPNSVREQVFRLDVDTNASATLTINGSRVTGELKLRK 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223278377  547 TSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:pfam02886 167 LQLELKESKVGLFDVELLQALLNYMVLNFLEPLLNEKLQRGFPLPLPAGIQLKDLHLQIHDRFLLIGA 234
 
Name Accession Description Interval E-value
BPI2 smart00329
BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
414-614 1.15e-53

BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain


Pssm-ID: 128624  Cd Length: 202  Bit Score: 181.74  E-value: 1.15e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   414 DNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPP--LTTATLGALIPKVFQQYPEScPLIIRIQVLNPPSVML 491
Cdd:smart00329   1 SDRMVYLALSEYFFNSLLFVYQQAGALKLTITDDMLPKESKflLTTCCFGTLVPEVAEQYPDS-TLQLEISVLSPPRVTL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   492 QKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKI 571
Cdd:smart00329  80 QPGGATVYIHASVKVFAILPDSSRASLFLMSVDTNVSAKSSFKTKKLLGELKLDKLQVELKHSNVGGFDAELLEDLLNYL 159
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 223278377   572 FDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:smart00329 160 VPAVLLPKVNEKLRRGVPLPLPCGVQLINPVLQVHDDFLLLGA 202
BPI1 smart00328
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
219-389 4.80e-37

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain


Pssm-ID: 214622 [Multi-domain]  Cd Length: 225  Bit Score: 137.52  E-value: 4.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   219 STVQGITGLRIVELTLPRVSVRLLPGVGVYLS---LYTRVAINGKSLIGFL------DIAVEVN-ITAKVRLTMDRTGYP 288
Cdd:smart00328  41 IGHYSIYSLSISRLELPSSLLRFQPSKGLRLSisnLSLRVSGDLKGSLNFIklegnfQLSVEGLsISADLRIESNASGRP 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377   289 RLVIERCDTLLGGIKVKL---LRGLLPNLVDNLVNRVLADVLPDLLCPIVD-VVLGLVNDQLGLVDSLIPLGILGSVQYT 364
Cdd:smart00328 121 TVTLSSCSSSIGDVRLHFsgsVLGWLINLFRKFIENTLRNVLEDQICPVIDsAVSNKMNDYLQTLPLSISLDSLIGVDYS 200
                          170       180
                   ....*....|....*....|....*
gi 223278377   365 FSSLPLVTGEFLELDLNTLVGEAGG 389
Cdd:smart00328 201 LVSPPRVTASFLDVRLKGKFFWKNH 225
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
219-340 4.09e-26

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 104.69  E-value: 4.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  219 STVQGITGLRIVELTLPRVSVRLLPGVGV-YLSLYTRVAINGKS--LIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERC 295
Cdd:pfam01273  36 KVLYNITNLKISNLQLPNLQLEFSPGGGLlLLIIPLTLKVSGKWplRGSFLELVVGVDITASLRLERDPQGRPTLVLSDC 115
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 223278377  296 DTLLGGIKVKLLRGL--LPNLVDNLVNRVLADVLPDLLCPIVDVVLG 340
Cdd:pfam01273 116 SSSPGSISISLLGGLgwLLDLLTNLLESTLPKVLQSQLCPVIQSVLS 162
BPI2 cd00026
BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
420-614 1.50e-23

BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 237993  Cd Length: 200  Bit Score: 98.53  E-value: 1.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 420 LAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPEScPLIIRIQVLNPPSVMLQKDKALVK 499
Cdd:cd00026    4 LAVSEHVFNSAALVYFQAGALNLLLTDDMPPSKSRLTTSIFGIFIPELAKKYPNM-PQQLKISVSSPPHLVLSEGGATLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 500 VLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPA 579
Cdd:cd00026   83 QQLDVEIFATLPDSQLRPLFRLGVDTSSSAQLSVSKKKLIGSLNLDRFLLELKSSNIGSFIPELLQAILTTILEITVLPN 162
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 223278377 580 MNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:cd00026  163 VNDKLRRGFPLPLPKNFTLYDAEIQVHKDFLLLGA 197
BPI1 cd00025
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
221-384 1.57e-21

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 237992  Cd Length: 223  Bit Score: 93.59  E-value: 1.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 221 VQGITGLRIVELTLPRVSVRLLPGVGVYLSLyTRVAINGK----------SLIGFLDIAVE-VNITAKVRLTMDRTGYPR 289
Cdd:cd00025   47 RVGLSNKEIQELKLPSSSIKLVEVKGLDLSI-SNVSIGLSgvwkynyrfiLDGGNVELSVEgMNIQADLRLGRDPSGRPK 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 290 LVIERCDTLLGGIKVKLL--RGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSS 367
Cdd:cd00025  126 LSLSDCSSTVGSLRVHLGgsLGWLAKLFMNFIESLLKKVLKGQLCPVIDASLVSMLESLLQLPKLPPVDSNAGVDYSLTS 205
                        170
                 ....*....|....*..
gi 223278377 368 LPLVTGEFLELDLNTLV 384
Cdd:cd00025  206 PPVLTASYLDSDIKGTF 222
LBP_BPI_CETP_C pfam02886
LBP / BPI / CETP family, C-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
394-614 5.40e-20

LBP / BPI / CETP family, C-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 397154  Cd Length: 238  Bit Score: 89.34  E-value: 5.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  394 YPLG--WPAVSPKPMPELPPMGDNTkSQLAMSANFLGSVLTLLQKQHALDLDITNGMfeeLPP-----LTTATLGALIPK 466
Cdd:pfam02886  12 FPLNhrSPVRFPPPVMALPEEHDRM-VYFAISDYFFNSALYVYHRAGFLKVTLTDDM---IPKdsdlrLTTKCFGPFLPL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377  467 VFQQYPEScPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEK 546
Cdd:pfam02886  88 LAEQYPNM-TLELEGSALSPPLLNFSPGGLTISPNASLNAFVVLPNSVREQVFRLDVDTNASATLTINGSRVTGELKLRK 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223278377  547 TSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA 614
Cdd:pfam02886 167 LQLELKESKVGLFDVELLQALLNYMVLNFLEPLLNEKLQRGFPLPLPAGIQLKDLHLQIHDRFLLIGA 234
BPI cd00264
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
229-381 2.65e-08

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 238164  Cd Length: 208  Bit Score: 54.31  E-value: 2.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 229 IVELTLPRVSVRLLPGvGVYLSLYTRVAINGK---SLIGFLDIAVEVNITAKVRLTMDrTGYPRLVIERCDTLLGGIKVK 305
Cdd:cd00264   59 LKILSLSSPTLKLSPK-GLDLSQSVSIELFVTwpaSDGGNPLFSLEVEISASLQLSVD-PGRLTLSLSLCSSTVELLSSN 136
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223278377 306 LL--RGLLPNLVDNLVNRVLadvlpdllCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLN 381
Cdd:cd00264  137 IGgfGNFIVSLLQKVLNTIL--------CPVVLPALNSKLRSGLPLLPVPPVPSPAGVDYSLTAEPVLSASFLLLDAD 206
BPI cd00264
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
420-614 5.49e-07

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 238164  Cd Length: 208  Bit Score: 50.46  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 420 LAMSANFLGSVLTLLQKQHALDLDITngmfEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVK 499
Cdd:cd00264    4 LRLSEDVLNSALQVYLKAGALLLTLT----IPDIPKALKLKLSGIIPLGAKKYPDMNLQLKILSLSSPTLKLSPKGLDLS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223278377 500 VLATAEVMVsQPKDLETTICLIDVDTEFLAS--FSTEGDKLMIDAKLEKTSLNLRTSN---VGNFDIGLMEVLVEKIFDL 574
Cdd:cd00264   80 QSVSIELFV-TWPASDGGNPLFSLEVEISASlqLSVDPGRLTLSLSLCSSTVELLSSNiggFGNFIVSLLQKVLNTILCP 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 223278377 575 AFMPAMNAVLGSGVPL------PKILNIDFSN-ADIDVLEDLLVLSA 614
Cdd:cd00264  159 VVLPALNSKLRSGLPLlpvppvPSPAGVDYSLtAEPVLSASFLLLDA 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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