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Conserved domains on  [gi|31563344|ref|NP_852124|]
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paired box protein Pax-3 isoform PAX3e [Homo sapiens]

Protein Classification

PAX and homeodomain domain-containing protein( domain architecture ID 11265427)

protein containing domains PAX, homeodomain, and Pax7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
34-159 2.04e-83

Paired Box domain;


:

Pssm-ID: 128645  Cd Length: 125  Bit Score: 253.78  E-value: 2.04e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 31563344    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Homeobox pfam00046
Homeobox domain;
222-275 6.82e-27

Homeobox domain;


:

Pssm-ID: 425441  Cd Length: 54  Bit Score: 102.59  E-value: 6.82e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31563344   222 SRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR 275
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
Pax7 pfam12360
Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino ...
347-391 2.25e-21

Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00046, pfam00292. Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.


:

Pssm-ID: 403540  Cd Length: 45  Bit Score: 86.84  E-value: 2.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 31563344   347 NPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQ 391
Cdd:pfam12360   1 SQDGGSAYCLSSGRHGFSSYSDSFVSPAGPSNPVNPSISNGLSPQ 45
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
34-159 2.04e-83

Paired Box domain;


Pssm-ID: 128645  Cd Length: 125  Bit Score: 253.78  E-value: 2.04e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 31563344    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
34-159 3.38e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 253.25  E-value: 3.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344    34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 31563344   114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX cd00131
Paired Box domain
34-161 5.46e-83

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 252.73  E-value: 5.46e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344  34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 31563344 114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
Homeobox pfam00046
Homeobox domain;
222-275 6.82e-27

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 102.59  E-value: 6.82e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31563344   222 SRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR 275
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
219-275 4.80e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 97.32  E-value: 4.80e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31563344    219 QRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR 275
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
220-277 9.49e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 96.93  E-value: 9.49e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31563344 220 RRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ 277
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Pax7 pfam12360
Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino ...
347-391 2.25e-21

Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00046, pfam00292. Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.


Pssm-ID: 403540  Cd Length: 45  Bit Score: 86.84  E-value: 2.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 31563344   347 NPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQ 391
Cdd:pfam12360   1 SQDGGSAYCLSSGRHGFSSYSDSFVSPAGPSNPVNPSISNGLSPQ 45
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
203-278 1.06e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 68.62  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344 203 EGSDIDSEPDLPLK----RKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQA 278
Cdd:COG5576  31 EVEAADSEMKLERKqdgsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
transpos_IS630 NF033545
IS630 family transposase;
56-224 2.03e-05

IS630 family transposase;


Pssm-ID: 411180 [Multi-domain]  Cd Length: 298  Bit Score: 46.48  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344   56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS-W- 131
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhWt 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344  132 --EIRDKLlkDAVCDRNTvpSVSSISRILRsKFG------KGEEEEADLERKEA-EESEKKAKHSIDG--ILSERASAPQ 200
Cdd:NF033545  81 lrELAALL--EEEFGVEY--SRSTVRRLLK-RLGlspkkpRPRAPKQDPEFVEKfKEVLGLYRAPPDPaeVVFIDESGIQ 155
                        170       180
                 ....*....|....*....|....
gi 31563344  201 SdegsdIDSEPDLPLKRKQRRSRT 224
Cdd:NF033545 156 L-----LDTRGRGWAPKGQRRPRV 174
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
34-159 2.04e-83

Paired Box domain;


Pssm-ID: 128645  Cd Length: 125  Bit Score: 253.78  E-value: 2.04e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 31563344    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
34-159 3.38e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 253.25  E-value: 3.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344    34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 31563344   114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX cd00131
Paired Box domain
34-161 5.46e-83

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 252.73  E-value: 5.46e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344  34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 31563344 114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
Homeobox pfam00046
Homeobox domain;
222-275 6.82e-27

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 102.59  E-value: 6.82e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31563344   222 SRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR 275
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
219-275 4.80e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 97.32  E-value: 4.80e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 31563344    219 QRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWR 275
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
220-277 9.49e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 96.93  E-value: 9.49e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31563344 220 RRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ 277
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Pax7 pfam12360
Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino ...
347-391 2.25e-21

Paired box protein 7; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00046, pfam00292. Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.


Pssm-ID: 403540  Cd Length: 45  Bit Score: 86.84  E-value: 2.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 31563344   347 NPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQ 391
Cdd:pfam12360   1 SQDGGSAYCLSSGRHGFSSYSDSFVSPAGPSNPVNPSISNGLSPQ 45
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
203-278 1.06e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 68.62  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344 203 EGSDIDSEPDLPLK----RKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQA 278
Cdd:COG5576  31 EVEAADSEMKLERKqdgsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
transpos_IS630 NF033545
IS630 family transposase;
56-224 2.03e-05

IS630 family transposase;


Pssm-ID: 411180 [Multi-domain]  Cd Length: 298  Bit Score: 46.48  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344   56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS-W- 131
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhWt 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563344  132 --EIRDKLlkDAVCDRNTvpSVSSISRILRsKFG------KGEEEEADLERKEA-EESEKKAKHSIDG--ILSERASAPQ 200
Cdd:NF033545  81 lrELAALL--EEEFGVEY--SRSTVRRLLK-RLGlspkkpRPRAPKQDPEFVEKfKEVLGLYRAPPDPaeVVFIDESGIQ 155
                        170       180
                 ....*....|....*....|....
gi 31563344  201 SdegsdIDSEPDLPLKRKQRRSRT 224
Cdd:NF033545 156 L-----LDTRGRGWAPKGQRRPRV 174
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
243-273 1.79e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 35.95  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 31563344   243 YPDIYTREELAQRAKLTEARVQVWFSNRRAR 273
Cdd:pfam05920   9 YPSEEEKAELAKETGLSRKQISNWFINARRR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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