NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29244320|ref|NP_808456|]
View 

exocyst complex component 3-like protein isoform 1 [Mus musculus]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 189-722 1.22e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 427.53  E-value: 1.22e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   189 FQGLGLLAEALGQAVEAAAGAAGRLAREDPA-LLVAAIRVAEVETERTILGQA-----------------------PRDW 244
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   245 RQRCLRALQEGLERVHFASPVLPEPGALAgwLEALQVA--LPAELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQ 322
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   323 LLAGPELGAADTFALLHWALHvYTGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 402
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   403 EWSGEQEPP-TDPSGFYHSPMPAIVLQILAENIQVTnliSDSLHRRAHNMAVSELGAFLRSFSDALIRFSRDHLRGDAVA 481
Cdd:pfam06046 236 DFTEREEPPeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   482 ------PHYVPYLLSAFNHQSALRSSVSVLLPDGE-------ASGVLAPVEAALDDVQRRICRLVLEVLQVELQPLFSAL 548
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEplkyeerISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   549 PSRRWLlSSELLDGVCEQTSHFCQDFWR-VRKPGVQLLLAEAERTVVLQYLRALMQGRLVCrGTDERSQAAERLRQDAAQ 627
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   628 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 704
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 29244320   705 AGPPPSPSTG--RRALFSLV 722
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 189-722 1.22e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 427.53  E-value: 1.22e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   189 FQGLGLLAEALGQAVEAAAGAAGRLAREDPA-LLVAAIRVAEVETERTILGQA-----------------------PRDW 244
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   245 RQRCLRALQEGLERVHFASPVLPEPGALAgwLEALQVA--LPAELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQ 322
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   323 LLAGPELGAADTFALLHWALHvYTGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 402
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   403 EWSGEQEPP-TDPSGFYHSPMPAIVLQILAENIQVTnliSDSLHRRAHNMAVSELGAFLRSFSDALIRFSRDHLRGDAVA 481
Cdd:pfam06046 236 DFTEREEPPeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   482 ------PHYVPYLLSAFNHQSALRSSVSVLLPDGE-------ASGVLAPVEAALDDVQRRICRLVLEVLQVELQPLFSAL 548
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEplkyeerISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   549 PSRRWLlSSELLDGVCEQTSHFCQDFWR-VRKPGVQLLLAEAERTVVLQYLRALMQGRLVCrGTDERSQAAERLRQDAAQ 627
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   628 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 704
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 29244320   705 AGPPPSPSTG--RRALFSLV 722
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
286-699 3.05e-07

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 53.79  E-value: 3.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 286 ELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQLLAgPELGAADTFALLHWAlhvytgKEMMGNLELGPEADVSQL 365
Cdd:COG5173 292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 366 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEWSGEQEPPT-DPSGFYHSPMPAIVLQILAENIQVTnlisdsl 444
Cdd:COG5173 365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFYARNEEPSrDSDGKLVLPGTVSLFQMITQQLEPI------- 437

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 445 hrrAHNMAVSELGAFLRSFSDALIRFS-------RDHLRGD------AVAPH-YVPYLLSAFNHQ-------SALRSSVS 503
Cdd:COG5173 438 ---AFTNRSDVVGIVFAHITRTITKYQeiwksnlVEEMDKQfksnpeSSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTF 514

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 504 VLLPDGEASGVLAPVEAALD---DVQRRICRLVLEVLQVELQPLFSALPSRRWLLSSELlDGVCEQTSHFCQDFWRVRKP 580
Cdd:COG5173 515 ELITSEYENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGGSVT-KVIVDTLQDYLSDYQNTMSE 593

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 581 GV-QLLLAEAERTVVLQYLRALMQGRlVCRGTDERSQAaerLRQDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLH 657
Cdd:COG5173 594 YLfVTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRN 669

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 29244320 658 DPTLLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 699
Cdd:COG5173 670 DDLFI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 189-722 1.22e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 427.53  E-value: 1.22e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   189 FQGLGLLAEALGQAVEAAAGAAGRLAREDPA-LLVAAIRVAEVETERTILGQA-----------------------PRDW 244
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   245 RQRCLRALQEGLERVHFASPVLPEPGALAgwLEALQVA--LPAELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQ 322
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   323 LLAGPELGAADTFALLHWALHvYTGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 402
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   403 EWSGEQEPP-TDPSGFYHSPMPAIVLQILAENIQVTnliSDSLHRRAHNMAVSELGAFLRSFSDALIRFSRDHLRGDAVA 481
Cdd:pfam06046 236 DFTEREEPPeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   482 ------PHYVPYLLSAFNHQSALRSSVSVLLPDGE-------ASGVLAPVEAALDDVQRRICRLVLEVLQVELQPLFSAL 548
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEplkyeerISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   549 PSRRWLlSSELLDGVCEQTSHFCQDFWR-VRKPGVQLLLAEAERTVVLQYLRALMQGRLVCrGTDERSQAAERLRQDAAQ 627
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320   628 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 704
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 29244320   705 AGPPPSPSTG--RRALFSLV 722
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
286-699 3.05e-07

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 53.79  E-value: 3.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 286 ELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQLLAgPELGAADTFALLHWAlhvytgKEMMGNLELGPEADVSQL 365
Cdd:COG5173 292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 366 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEWSGEQEPPT-DPSGFYHSPMPAIVLQILAENIQVTnlisdsl 444
Cdd:COG5173 365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFYARNEEPSrDSDGKLVLPGTVSLFQMITQQLEPI------- 437

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 445 hrrAHNMAVSELGAFLRSFSDALIRFS-------RDHLRGD------AVAPH-YVPYLLSAFNHQ-------SALRSSVS 503
Cdd:COG5173 438 ---AFTNRSDVVGIVFAHITRTITKYQeiwksnlVEEMDKQfksnpeSSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTF 514

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 504 VLLPDGEASGVLAPVEAALD---DVQRRICRLVLEVLQVELQPLFSALPSRRWLLSSELlDGVCEQTSHFCQDFWRVRKP 580
Cdd:COG5173 515 ELITSEYENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGGSVT-KVIVDTLQDYLSDYQNTMSE 593

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244320 581 GV-QLLLAEAERTVVLQYLRALMQGRlVCRGTDERSQAaerLRQDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLH 657
Cdd:COG5173 594 YLfVTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRN 669

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 29244320 658 DPTLLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 699
Cdd:COG5173 670 DDLFI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH