NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|25145850|ref|NP_740905|]
View 

RGS domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 280-405 1.38e-63

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08705:

Pssm-ID: 470619  Cd Length: 121  Bit Score: 200.54  E-value: 1.38e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08705   1 RVKRWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQVPEKVQEIYQEFLAPGAPSWINIDSKTME 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 25145850 360 QTLECISKAkdasqMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08705  81 ITLKNLKDP-----HRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121
RGS_DHEX super family cl39527
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 91-190 1.74e-26

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


The actual alignment was detected with superfamily member pfam18148:

Pssm-ID: 375589  Cd Length: 100  Bit Score: 102.23  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850    91 PYFWPSQAELVPDVEYAIYLNKRLLRNEQKhgLEEDEVESFNRLADVLAHMWAFIVQQSELQLKQQKEKKKVDKVVFDSE 170
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQR--LEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQ 78

                          90       100
                  ....*....|....*....|
gi 25145850   171 ERAFWKIRKPSRGGPNFLED 190
Cdd:pfam18148  79 ERAFWLVHRPPPGQVNVLEY 98
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 18-94 3.23e-25

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


:

Pssm-ID: 239897  Cd Length: 88  Bit Score: 98.52  E-value: 3.23e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25145850  18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRLQRPYFW 94
Cdd:cd04450  12 GVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTDVVDPSEALEIAALFVKYGLITPVSDHRSLLKPDETLYRFQAPYFW 88
GGL smart00224
G protein gamma subunit-like motifs;
204-266 1.02e-17

G protein gamma subunit-like motifs;


:

Pssm-ID: 128520  Cd Length: 63  Bit Score: 76.93  E-value: 1.02e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25145850    204 AQGYRCLMDRLRFAIKTKpWLKALKASDTMVTWVDQRAEFDPFLHPPQPS-NPWISDEASFWNQ 266
Cdd:smart00224   1 KDQLRKEVEQLRKELSRE-RIKVSKAAEELLAYCEQHAEEDPLLTGPPPSkNPFIEDKTSCWIL 63
 
Name Accession Description Interval E-value
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 280-405 1.38e-63

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 200.54  E-value: 1.38e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08705   1 RVKRWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQVPEKVQEIYQEFLAPGAPSWINIDSKTME 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 25145850 360 QTLECISKAkdasqMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08705  81 ITLKNLKDP-----HRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 287-404 1.10e-33

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 122.34  E-value: 1.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850   287 SVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECI 365
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPdEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 25145850   366 SKAKdasqMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:pfam00615  81 EKEP----TRDLFDEAQAEVYELMEKDSYPRFLKSPLYL 115
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 287-404 2.10e-31

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 116.21  E-value: 2.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850    287 SVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECI 365
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDdEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 25145850    366 skaKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:smart00315  81 ---ESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYL 116
RGS_DHEX pfam18148
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 91-190 1.74e-26

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


Pssm-ID: 375589  Cd Length: 100  Bit Score: 102.23  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850    91 PYFWPSQAELVPDVEYAIYLNKRLLRNEQKhgLEEDEVESFNRLADVLAHMWAFIVQQSELQLKQQKEKKKVDKVVFDSE 170
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQR--LEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQ 78

                          90       100
                  ....*....|....*....|
gi 25145850   171 ERAFWKIRKPSRGGPNFLED 190
Cdd:pfam18148  79 ERAFWLVHRPPPGQVNVLEY 98
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 18-94 3.23e-25

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


Pssm-ID: 239897  Cd Length: 88  Bit Score: 98.52  E-value: 3.23e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25145850  18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRLQRPYFW 94
Cdd:cd04450  12 GVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTDVVDPSEALEIAALFVKYGLITPVSDHRSLLKPDETLYRFQAPYFW 88
GGL smart00224
G protein gamma subunit-like motifs;
204-266 1.02e-17

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 76.93  E-value: 1.02e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25145850    204 AQGYRCLMDRLRFAIKTKpWLKALKASDTMVTWVDQRAEFDPFLHPPQPS-NPWISDEASFWNQ 266
Cdd:smart00224   1 KDQLRKEVEQLRKELSRE-RIKVSKAAEELLAYCEQHAEEDPLLTGPPPSkNPFIEDKTSCWIL 63
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 18-90 3.38e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.09  E-value: 3.38e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25145850     18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVI-EHGQPFKDDGTLYRLQR 90
Cdd:smart00049   4 GLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEIIDREEAVHLGQLLLDEGLIHHVNgPNKHTFKDSKALYRFTT 77
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 18-88 1.86e-14

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 68.00  E-value: 1.86e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25145850    18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRL 88
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDNLEIITREEAVELGQLLLDQGLIHHVGDKHGLFKDSYYFYRF 71
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 201-266 9.26e-14

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 65.83  E-value: 9.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850   201 RQNAQGYRCLMDRLRFAIKtKPWLKALKASDTMVTWVDQRAEFDPFLH----PPQPSNPWISDEASFWNQ 266
Cdd:pfam00631   1 KQLKLKLKREIEQLREELK-RERIKVSKACEELIDYCEQRSTKDPLLPgvwgPPAGENPWREDDGCCWIL 69
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 204-260 1.05e-13

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 65.39  E-value: 1.05e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25145850 204 AQGYRCLMDRLRFAIKTKpWLKALKASDTMVTWVDQRAEFDPFLHPP-QPSNPWISDE 260
Cdd:cd00068   1 VDQLKKEVEQLRKELSRE-RLKVSKAAAELLKYCEQNAENDPLLTGPpSPSNPWIEKK 57
 
Name Accession Description Interval E-value
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 280-405 1.38e-63

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 200.54  E-value: 1.38e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08705   1 RVKRWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKYGPQSQVPEKVQEIYQEFLAPGAPSWINIDSKTME 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 25145850 360 QTLECISKAkdasqMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08705  81 ITLKNLKDP-----HRYTFDAAQEHIYMLMKKDSYPRFLRSDIYKE 121
RGS_RGS6 cd08737
Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of ...
 279-407 9.90e-41

Regulator of G protein signaling (RGS) domain found in the RGS6 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS6 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes. Mutations of a critical residue required for interaction of RGS6 protein with G proteins did not affect the ability of RGS6 to interact with both SCG10 and DMAP1. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis.


Pssm-ID: 188691  Cd Length: 125  Bit Score: 141.31  E-value: 9.90e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 279 KRVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTL 358
Cdd:cd08737   1 QRVKRWGFSLDEVLKDPVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 25145850 359 DQTLECIskaKDASqmRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKAVL 407
Cdd:cd08737  81 EKTSQNV---KDPG--RYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLL 124
RGS_RGS7 cd08738
Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of ...
 280-404 2.93e-38

Regulator of G protein signaling (RGS) domain found in the RGS7 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS7 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. R7 RGS proteins are key modulators of the pharmacological effects of drugs involved in the development of tolerance and addiction. In addition, RGS7 was found to bind a component of the synaptic fusion complex, snapin, and some other proteins outside of G protein signaling pathways.


Pssm-ID: 188692  Cd Length: 121  Bit Score: 134.46  E-value: 2.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08738   1 RVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQEIWQEFLAPGAPSAINLDSKSYD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25145850 360 QTLECIskaKDASqmRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08738  81 KTTQNV---KDPG--RYTFEDAQEHIYKLMKSDSYPRFIRSSAYQ 120
RGS_RGS11 cd08740
Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...
 280-407 9.47e-34

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.


Pssm-ID: 188694  Cd Length: 126  Bit Score: 122.71  E-value: 9.47e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08740   2 RVERWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRYGEQSKIPELVDSVYQQFLAPGATRWVNIDSKTME 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 25145850 360 QTLECISKAKdasqmRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKAVL 407
Cdd:cd08740  82 RTLEGLKQPH-----RYVLDDAQMHIYMLMKKDSYPRFLKSDLYKNLL 124
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 287-404 1.10e-33

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 122.34  E-value: 1.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850   287 SVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECI 365
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPdEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIRENL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 25145850   366 SKAKdasqMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:pfam00615  81 EKEP----TRDLFDEAQAEVYELMEKDSYPRFLKSPLYL 115
RGS_RGS9 cd08739
Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of ...
 280-404 4.76e-32

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.


Pssm-ID: 188693  Cd Length: 121  Bit Score: 118.21  E-value: 4.76e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 280 RVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLD 359
Cdd:cd08739   1 RVERWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25145850 360 QTLECISKAKdasqmRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08739  81 ITVKGLKHPH-----RYVLDAAQTHIYMLMKKDSYARYLKSPIYK 120
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 287-404 2.10e-31

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 116.21  E-value: 2.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850    287 SVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECI 365
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDdEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIEENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 25145850    366 skaKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:smart00315  81 ---ESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYL 116
RGS_DHEX pfam18148
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 91-190 1.74e-26

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


Pssm-ID: 375589  Cd Length: 100  Bit Score: 102.23  E-value: 1.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850    91 PYFWPSQAELVPDVEYAIYLNKRLLRNEQKhgLEEDEVESFNRLADVLAHMWAFIVQQSELQLKQQKEKKKVDKVVFDSE 170
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQR--LEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQ 78

                          90       100
                  ....*....|....*....|
gi 25145850   171 ERAFWKIRKPSRGGPNFLED 190
Cdd:pfam18148  79 ERAFWLVHRPPPGQVNVLEY 98
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 18-94 3.23e-25

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


Pssm-ID: 239897  Cd Length: 88  Bit Score: 98.52  E-value: 3.23e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25145850  18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRLQRPYFW 94
Cdd:cd04450  12 GVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTDVVDPSEALEIAALFVKYGLITPVSDHRSLLKPDETLYRFQAPYFW 88
RGS_RGS5 cd08717
Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...
 288-404 2.39e-24

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.


Pssm-ID: 188672  Cd Length: 114  Bit Score: 96.99  E-value: 2.39e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 288 VQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNE-QIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECIS 366
Cdd:cd08717   1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPlKMATKAKKIYEEFIQTEAPKEVNIDHFTKDVTMKNLV 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25145850 367 KAKDASqmrfaFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08717  81 EPSSSS-----FDLAQKRIFALMEKDSLPRFVRSEFYQ 113
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 288-403 4.00e-24

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 96.17  E-value: 4.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 288 VQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLEcisK 367
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKEFVQSDAAKQINIDFRTRESTAK---K 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25145850 368 AKDASQMrfAFYHSEEHVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08715  78 IKAPTPT--CFDEAQKVIYILMERDSYPRFLKSDIY 111
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 284-405 2.40e-23

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 94.35  E-value: 2.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 284 WGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQ-IYQKAERIREEFLAQGAPAQVNVDNRtldqTL 362
Cdd:cd08745   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHvIDEKARLIYEDYISILSPKEVSLDSR----VR 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25145850 363 ECISKaKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08745  77 EGINR-KMQEPSSHTFDDAQLQIYTLMHRDSYPRFLNSPIYKA 118
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 276-404 8.52e-23

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 94.28  E-value: 8.52e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 276 PTEKRVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQ-IYQKAERIREEFLAQGAPAQVNVD 354
Cdd:cd08746  42 PTLEEVCAWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKSvIEEKARIIYEDYISILSPKEVSLD 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 25145850 355 NRtldqTLECISKAKdASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08746 122 SR----VREVINRNM-LEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYK 166
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 284-405 3.56e-21

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 88.29  E-value: 3.56e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 284 WGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKY-APNEQIYQKAERIREEFLAQGAPAQVNVDNRtldqTL 362
Cdd:cd08718   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKKeANKHVIEEKARLIYEDYISILSPKEVSLDSR----VR 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25145850 363 ECISKaKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08718  77 EVINR-NMLEPSPHTFDDAQLQIYTLMHRDSYPRFLNSAIYKS 118
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 291-404 7.90e-21

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 87.03  E-value: 7.90e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 291 LVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAK 369
Cdd:cd08723   1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTKSsTEIALKAQMIYSEFIQADAPKEINIDFHTRDLISQNISEPT 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25145850 370 DAsqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08723  81 LK-----CFDEAQSLIYCLMAKDSFPRFLKSEVYK 110
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 291-404 8.93e-21

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 86.99  E-value: 8.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 291 LVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDN--RTLDQTLECISK 367
Cdd:cd08706   4 LLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKIPDkKQLVQEAREIYDTFLSSKASSPVNIDSqaQLAEEMLEEPHP 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25145850 368 AkdasqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08706  84 D--------MFQKQQLQIFNLMKFDSYSRFLKSPLYQ 112
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 297-403 1.04e-20

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 86.85  E-value: 1.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 297 GRQVLETFLESEFSSENIRFWIAIQDLK-YAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISkakdaSQMR 375
Cdd:cd08713  10 GLAVFRAFLQTEFSEENLEFWLACEEYKkIKSQSKMASRAKKIFAEYIAIQSCKEVNLDSYTREHTKENLQ-----NPTR 84

                        90       100
                ....*....|....*....|....*...
gi 25145850 376 FAFYHSEEHVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08713  85 GCFDLAQKRIYGLMEKDSYPRFLRSDLY 112
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 278-409 3.09e-20

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 86.24  E-value: 3.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 278 EKRVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN---EQIYQKAERIREEFLAQGAPAQVNVD 354
Cdd:cd08743   1 EKSVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPAsdtQQLAQEARKIYNEFLSSSSQSPVNID 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 25145850 355 NRTLdqtlecISKAKDASQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIYKAVLTA 409
Cdd:cd08743  81 QQAW------IGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQDCLLA 129
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 290-404 7.17e-20

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 84.72  E-value: 7.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 290 ELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQ-IYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKA 368
Cdd:cd08709   3 ELLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTKSPQkLTSKAKKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEA 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25145850 369 KDAsqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08709  83 TSG-----CFTAAQKRVYSLMENNSYPRFLESEFYQ 113
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 289-403 1.09e-19

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 84.16  E-value: 1.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 289 QELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVDNRTLDQT----LE 363
Cdd:cd08714   2 ENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSpSKLSPKARKIYEEFISVQATKEVNLDSCTREETsrnmLE 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 25145850 364 CISKAKDASQMRfafyhseehVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08714  82 PTISCFDEAQKK---------IFTLMEKDSYRRFLKSRFY 112
RGS_RGS18 cd08712
Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...
 297-403 2.39e-19

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.


Pssm-ID: 188667  Cd Length: 114  Bit Score: 83.06  E-value: 2.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 297 GRQVLETFLESEFSSENIRFWIAIQDLKYAP-NEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAKDASqmr 375
Cdd:cd08712  10 GLEAFTRFLKTEFSEENIEFWIACEDYKKSKtPQQIHLKAKAIYEKFIQTDAPKEVNLDFHTKEVTTNSIEQPTLTS--- 86

                        90       100
                ....*....|....*....|....*...
gi 25145850 376 faFYHSEEHVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08712  87 --FDAAQSRVYQLMEQDSYPRFLKSDIY 112
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 294-404 2.53e-19

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 82.82  E-value: 2.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 294 DPIGRQVLETFLESEFSSENIRFWIAIQDLK--YAPNEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAKDA 371
Cdd:cd07440   3 DPYGLEYFRQFLKSEHCEENLEFWLAVEKFKktTSSDEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPYPD 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 25145850 372 SQMrfaFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd07440  83 PDC---FDEAQEHILNLLEKDSYPRFLKSDLYL 112
RGS_RGS16 cd08710
Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator ...
 291-404 1.14e-18

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.


Pssm-ID: 188665  Cd Length: 114  Bit Score: 81.27  E-value: 1.14e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 291 LVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNE-QIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAK 369
Cdd:cd08710   4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSAtKLASRAHHIFEEFIRSEAPKEVNIDHETRELTRTNLQAAT 83

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25145850 370 DAsqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08710  84 TS-----CFDVAQGKTRTLMEKDSYPRFLKSPAYR 113
RGS_RGS10 cd08741
Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of ...
 288-403 3.45e-18

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.


Pssm-ID: 188695  Cd Length: 113  Bit Score: 79.70  E-value: 3.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 288 VQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPN-EQIYQKAERIREEFLAQGAPAQVNVD--NRTLDQTLEc 364
Cdd:cd08741   1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDkTQMQEKAKEIYMTFLSSKASSQVNVEgqSRLNEKILE- 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25145850 365 iskakdaSQMRFAFYHSEEHVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08741  80 -------EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLF 111
RGS_RGS8 cd08711
Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of ...
 277-403 4.66e-18

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).


Pssm-ID: 188666  Cd Length: 125  Bit Score: 79.78  E-value: 4.66e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 277 TEKRVKRWGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYA-PNEQIYQKAERIREEFLAQGAPAQVNVDN 355
Cdd:cd08711   1 STEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTrSTAKLVSKAHRIFEEFVDVQAPREVNIDF 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 25145850 356 RTLDQTLECISKAKDAsqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIY 403
Cdd:cd08711  81 QTREATRKNLQEPSLT-----CFDQAQGKVHSLMEKDSYPRFLRSKMY 123
GGL smart00224
G protein gamma subunit-like motifs;
204-266 1.02e-17

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 76.93  E-value: 1.02e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25145850    204 AQGYRCLMDRLRFAIKTKpWLKALKASDTMVTWVDQRAEFDPFLHPPQPS-NPWISDEASFWNQ 266
Cdd:smart00224   1 KDQLRKEVEQLRKELSRE-RIKVSKAAEELLAYCEQHAEEDPLLTGPPPSkNPFIEDKTSCWIL 63
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 284-405 7.85e-17

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 76.31  E-value: 7.85e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 284 WGLSVQELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQ-IYQKAERIREEFLAQGAPAQVNVDNRtldqTL 362
Cdd:cd08744   1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKvIEEKARLIYEDYISILSPKEVSLDSR----VR 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25145850 363 ECISKAKDASQMRFaFYHSEEHVFTLMAKDSYPRFVRSQIYKA 405
Cdd:cd08744  77 EVINRNLLDPNPHM-YEDAQLQIYTLMHRDSFPRFLNSQIYKS 118
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 18-90 3.38e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.09  E-value: 3.38e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25145850     18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVI-EHGQPFKDDGTLYRLQR 90
Cdd:smart00049   4 GLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEIIDREEAVHLGQLLLDEGLIHHVNgPNKHTFKDSKALYRFTT 77
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 18-88 1.86e-14

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 68.00  E-value: 1.86e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25145850    18 GAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYRL 88
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDNLEIITREEAVELGQLLLDQGLIHHVGDKHGLFKDSYYFYRF 71
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 201-266 9.26e-14

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 65.83  E-value: 9.26e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850   201 RQNAQGYRCLMDRLRFAIKtKPWLKALKASDTMVTWVDQRAEFDPFLH----PPQPSNPWISDEASFWNQ 266
Cdd:pfam00631   1 KQLKLKLKREIEQLREELK-RERIKVSKACEELIDYCEQRSTKDPLLPgvwgPPAGENPWREDDGCCWIL 69
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 204-260 1.05e-13

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 65.39  E-value: 1.05e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 25145850 204 AQGYRCLMDRLRFAIKTKpWLKALKASDTMVTWVDQRAEFDPFLHPP-QPSNPWISDE 260
Cdd:cd00068   1 VDQLKKEVEQLRKELSRE-RLKVSKAAAELLKYCEQNAENDPLLTGPpSPSNPWIEKK 57
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 289-404 7.10e-13

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 65.08  E-value: 7.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 289 QELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAP---NEQIYQKAERIREEFLAQGAPAQVNVDNRTldQTLECI 365
Cdd:cd08742   2 ERLLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPahdKKELSYRAREIFSKFLCSKATTPVNIDSQA--QLADDI 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25145850 366 SKAKDASQmrfaFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08742  80 LNAPHPDM----FKEQQLQIFNLMKFDSYTRFLKSPLYQ 114
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 8-87 8.45e-12

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 60.82  E-value: 8.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850   8 IEVLAKRVMEGAQLKTHKYFRIAVPHAITGQQLIALVLERGAPDDEAEASHLASLLLHHGYMFPVIEHGQPFKDDGTLYR 87
Cdd:cd04371   2 LVRIMLDSDSGVPIKDRKYHLKTYPNCFTGSELVDWLLDNLEAITREEAVELGQALLKHGLIHHVSDDKHTFRDSYALYR 81
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 289-404 4.23e-10

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 56.86  E-value: 4.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 289 QELVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNE--QIYqKAERIREEFLAQGAPAQVNVDNRTLDQTLECIS 366
Cdd:cd08716   2 ENLMATKYGPIIYATYLKTEHSDENIEFWLACETYKKIASQrkRIS-MARKLFASYIQPQAPREINIDSPTRKAIIRNIQ 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25145850 367 KAKDAsqmrfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08716  81 EPTQS-----CFDEAQRIVYMHMERDSYPRFLESKFYQ 113
RGS-like_1 cd08734
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These ...
 294-399 6.43e-07

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 1; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188688  Cd Length: 109  Bit Score: 47.85  E-value: 6.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 294 DPIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQI-YQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKAKDA- 371
Cdd:cd08734   1 DPNTSPLFGFSAESDFSGENLSFLTLVKEYKRLSNPAEkFTLASKIYKEFISSESPFQINISSAMLRRLDNDFELLTGAf 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 25145850 372 ----SQMRFAFyhsEEHVFTLMAKDSYPRFVR 399
Cdd:cd08734  81 anvdSGLNTPF---NEEISKIEASDLYPAFVK 109
RGS_FLBA cd08708
Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The ...
 288-405 1.03e-06

Regulator of G protein signaling (RGS) domain found in the FLBA (Fluffy Low BrlA) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the FLBA (Fluffy Low BrlA) protein. FLBA is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain accelerates the GTPase activity of the alpha subunit by hydrolysis of GTP to GDP which results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. The RGS domain of the FLBA protein antagonizes G protein signaling to block proliferation and allow development. It is required for control of mycelial proliferation and activation of asexual sporulation in yeast.


Pssm-ID: 188663  Cd Length: 148  Bit Score: 48.14  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 288 VQELVKDPIGRQVLETFLESEFSSENIRFWIAIQD--------LKYAPNEQIYQKAERIREE-----------FLAQGAP 348
Cdd:cd08708   2 LDKILKDPGLRYLFREHLEKEFCEENLSFYLEVKEflkkmtilSKLLDFKSSQAADEDLDREslaqayhiyntYLAPGSP 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25145850 349 AQVNVD----NRTLDQTLECI-----SKAKDASQMRFAFYHSEEHVF-TLMAKDSYPRFVRSQIYKA 405
Cdd:cd08708  82 CELNIDhnlrNRITTIMTEKIvgeddSMAESLQGVEALFEEAQNAVFkPLMAGDSVPKFLKQPEYLG 148
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 295-404 1.15e-05

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 44.33  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 295 PIGRQVLETFLESEFSSENIRFWIAIQDLKYAPNEQIYQKAERIREEFLAQgAPAQVNVDNRTLDQTLECISKAKDASqm 374
Cdd:cd08720   5 VFGRKYLSQFLERMDSQALIGFWEAVEELRSANKSEWHQLGAEIFYTFIVE-PTAEIKVDKSLRKRIEQFLLGDKGPE-- 81

                        90       100       110
                ....*....|....*....|....*....|
gi 25145850 375 rfAFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08720  82 --VFYEVQENVVETLEEKYYPSFVVSDQYK 109
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 291-404 2.86e-04

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 40.52  E-value: 2.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25145850 291 LVKDPIGRQVLETFLESEFSSENIRFWIAIQDLKYA--PNEQIYQKAERIREEFLAQGAPAQVNVDNRTLDQTLECISKA 368
Cdd:cd08707   4 LLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMsdSEEKRSKLAKAIYRRYIKDNGIVSRQLKPATKSFIKECIKKQ 83

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25145850 369 KDASQMrfaFYHSEEHVFTLMAKDSYPRFVRSQIYK 404
Cdd:cd08707  84 QLDPAM---FDQAQTEIQTTMEENTYPSFLKSDIYL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH