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Conserved domains on  [gi|24648166|ref|NP_732412|]
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delta, isoform B [Drosophila melanogaster]

Protein Classification

MNNL and DSL domain-containing protein( domain architecture ID 10541877)

protein containing domains MNNL, DSL, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 23-182 1.67e-65

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


:

Pssm-ID: 462222  Cd Length: 157  Bit Score: 215.62  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166    23 SGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDA 102
Cdd:pfam07657   1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQCRDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166   103 QRfqnKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRV 182
Cdd:pfam07657  81 LK---GSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
164-226 1.04e-23

delta serrate ligand;


:

Pssm-ID: 128366  Cd Length: 63  Bit Score: 94.70  E-value: 1.04e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24648166    164 WKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYC 226
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 529-564 5.83e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 5.83e-09
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 529 DIDECSSG-PCHNGGTCMNRVNSFECVCANGFRGKQC 564
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 453-488 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 5.22e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 453 NIDDCL-GHQCENGGTCIDMVNQYRCQCVPGFHGTHC 488
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 291-329 7.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.58e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24648166 291 DLNYCTNHRPCKNGGTCFNTgEGLYTCKCAPGYSGDDCE 329
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 492-526 1.63e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.63e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 492 VDLCLIR-PCANGGTCLNLNNDYQCTCRAGFTGKDC 526
Cdd:cd00054   2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 337-372 1.80e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.80e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 337 ADVNPCQNGGTCIDephTKTGYKCHCANGWSGKMCE 372
Cdd:cd00054   6 ASGNPCQNGGTCVN---TVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 23-182 1.67e-65

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 215.62  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166    23 SGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDA 102
Cdd:pfam07657   1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQCRDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166   103 QRfqnKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRV 182
Cdd:pfam07657  81 LK---GSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
164-226 1.04e-23

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 94.70  E-value: 1.04e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24648166    164 WKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYC 226
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 184-229 3.34e-17

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 75.74  E-value: 3.34e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 24648166   184 CDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIP 229
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 529-564 5.83e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 5.83e-09
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 529 DIDECSSG-PCHNGGTCMNRVNSFECVCANGFRGKQC 564
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
529-565 1.82e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 1.82e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24648166    529 DIDECSSG-PCHNGGTCMNRVNSFECVCANGFR-GKQCD 565
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 453-488 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 5.22e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 453 NIDDCL-GHQCENGGTCIDMVNQYRCQCVPGFHGTHC 488
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 291-329 7.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.58e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24648166 291 DLNYCTNHRPCKNGGTCFNTgEGLYTCKCAPGYSGDDCE 329
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
453-488 5.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24648166    453 NIDDCL-GHQCENGGTCIDMVNQYRCQCVPGFH-GTHC 488
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 492-526 1.63e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.63e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 492 VDLCLIR-PCANGGTCLNLNNDYQCTCRAGFTGKDC 526
Cdd:cd00054   2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
291-329 2.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.58e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24648166    291 DLNYCTNHRPCKNGGTCFNTgEGLYTCKCAPGYS-GDDCE 329
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNT-VGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 337-372 1.80e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.80e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 337 ADVNPCQNGGTCIDephTKTGYKCHCANGWSGKMCE 372
Cdd:cd00054   6 ASGNPCQNGGTCVN---TVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 533-563 2.36e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24648166   533 CSSGPCHNGGTCMNRVNSFECVCANGFRGKQ 563
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-526 4.97e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24648166    492 VDLCLIR-PCANGGTCLNLNNDYQCTCRAGFT-GKDC 526
Cdd:smart00179   2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 457-485 2.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*....
gi 24648166   457 CLGHQCENGGTCIDMVNQYRCQCVPGFHG 485
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 495-525 3.35e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.35e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24648166   495 CLIRPCANGGTCLNLNNDYQCTCRAGFTGKD 525
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 340-369 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 4.63e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 24648166   340 NPCQNGGTCIDEPhtkTGYKCHCANGWSGK 369
Cdd:pfam00008   4 NPCSNGGTCVDTP---GGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 300-327 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*...
gi 24648166   300 PCKNGGTCFNTGEGlYTCKCAPGYSGDD 327
Cdd:pfam00008   5 PCSNGGTCVDTPGG-YTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
337-372 9.54e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24648166    337 ADVNPCQNGGTCIDephTKTGYKCHCANGWS-GKMCE 372
Cdd:smart00179   6 ASGNPCQNGGTCVN---TVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 23-182 1.67e-65

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 215.62  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166    23 SGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDA 102
Cdd:pfam07657   1 SGYFELQLLSFENPNGRLANGNCCDGGRSSSDGQCRDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648166   103 QRfqnKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRV 182
Cdd:pfam07657  81 LK---GSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDSGSDNPRLIERAIHQGMLNPGDEWQTLRHNGGVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
164-226 1.04e-23

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 94.70  E-value: 1.04e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24648166    164 WKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYC 226
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 184-229 3.34e-17

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 75.74  E-value: 3.34e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 24648166   184 CDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIP 229
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 529-564 5.83e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 5.83e-09
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 529 DIDECSSG-PCHNGGTCMNRVNSFECVCANGFRGKQC 564
Cdd:cd00054   1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
529-565 1.82e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 1.82e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24648166    529 DIDECSSG-PCHNGGTCMNRVNSFECVCANGFR-GKQCD 565
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 453-488 5.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 5.22e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24648166 453 NIDDCL-GHQCENGGTCIDMVNQYRCQCVPGFHGTHC 488
Cdd:cd00054   1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 291-329 7.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.58e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24648166 291 DLNYCTNHRPCKNGGTCFNTgEGLYTCKCAPGYSGDDCE 329
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
453-488 5.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24648166    453 NIDDCL-GHQCENGGTCIDMVNQYRCQCVPGFH-GTHC 488
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 492-526 1.63e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.63e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 492 VDLCLIR-PCANGGTCLNLNNDYQCTCRAGFTGKDC 526
Cdd:cd00054   2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
291-329 2.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.58e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24648166    291 DLNYCTNHRPCKNGGTCFNTgEGLYTCKCAPGYS-GDDCE 329
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNT-VGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 337-372 1.80e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.80e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24648166 337 ADVNPCQNGGTCIDephTKTGYKCHCANGWSGKMCE 372
Cdd:cd00054   6 ASGNPCQNGGTCVN---TVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 533-563 2.36e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24648166   533 CSSGPCHNGGTCMNRVNSFECVCANGFRGKQ 563
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-526 4.97e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24648166    492 VDLCLIR-PCANGGTCLNLNNDYQCTCRAGFT-GKDC 526
Cdd:smart00179   2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 532-562 6.25e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 6.25e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 24648166 532 ECS-SGPCHNGGTCMNRVNSFECVCANGFRGK 562
Cdd:cd00053   1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 295-326 1.20e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.20e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24648166 295 CTNHRPCKNGGTCFNTgEGLYTCKCAPGYSGD 326
Cdd:cd00053   2 CAASNPCSNGGTCVNT-PGSYRCVCPPGYTGD 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 457-485 2.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*....
gi 24648166   457 CLGHQCENGGTCIDMVNQYRCQCVPGFHG 485
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 495-525 3.35e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.35e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24648166   495 CLIRPCANGGTCLNLNNDYQCTCRAGFTGKD 525
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 462-483 3.62e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.39  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|..
gi 24648166   462 CENGGTCIDMVNQYRCQCVPGF 483
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 340-369 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 4.63e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 24648166   340 NPCQNGGTCIDEPhtkTGYKCHCANGWSGK 369
Cdd:pfam00008   4 NPCSNGGTCVDTP---GGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 300-327 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*...
gi 24648166   300 PCKNGGTCFNTGEGlYTCKCAPGYSGDD 327
Cdd:pfam00008   5 PCSNGGTCVDTPGG-YTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 460-487 4.94e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 4.94e-03
                        10        20
                ....*....|....*....|....*...
gi 24648166 460 HQCENGGTCIDMVNQYRCQCVPGFHGTH 487
Cdd:cd00053   6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 499-524 5.04e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 5.04e-03
                        10        20
                ....*....|....*....|....*.
gi 24648166 499 PCANGGTCLNLNNDYQCTCRAGFTGK 524
Cdd:cd00053   7 PCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
337-372 9.54e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24648166    337 ADVNPCQNGGTCIDephTKTGYKCHCANGWS-GKMCE 372
Cdd:smart00179   6 ASGNPCQNGGTCVN---TVGSYRCECPPGYTdGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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