NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|23943793|ref|NP_705735.1|]
View 

AMMECR1-like protein isoform 2 [Mus musculus]

Protein Classification

AMMECR1 domain-containing protein (domain architecture ID 10486934)

AMMECR1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
110-279 1.25e-72

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


:

Pssm-ID: 334718  Cd Length: 166  Bit Score: 221.15  E-value: 1.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   110 CYCFDVLYCHLYG---FPQPRLPRFTNDPYPLFVTWKTgRDKRLRGCIGTFSA-MNLHSGLREYTLTSALKDSRFPPLTR 185
Cdd:pfam01871   1 RLAREAIESYLKGgkpLPPEDPPPLLNEKRGVFVTLKK-KNGELRGCIGTLEPvRPLAEEIIENAIAAAFRDPRFPPLTP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   186 EELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGiKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKApiTSE 265
Cdd:pfam01871  80 DELPDLEIEVSVLTPPEPIDDPEDLEPGRHGLII----EKG-GRSGLLLPQVAVEQGWDPEEFLDHLCRKAGLPP--DAW 152
                         170
                  ....*....|....
gi 23943793   266 FRKSIKLTRYRSEK 279
Cdd:pfam01871 153 SDEDIKLYRFEVEV 166
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
110-279 1.25e-72

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 334718  Cd Length: 166  Bit Score: 221.15  E-value: 1.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   110 CYCFDVLYCHLYG---FPQPRLPRFTNDPYPLFVTWKTgRDKRLRGCIGTFSA-MNLHSGLREYTLTSALKDSRFPPLTR 185
Cdd:pfam01871   1 RLAREAIESYLKGgkpLPPEDPPPLLNEKRGVFVTLKK-KNGELRGCIGTLEPvRPLAEEIIENAIAAAFRDPRFPPLTP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   186 EELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGiKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKApiTSE 265
Cdd:pfam01871  80 DELPDLEIEVSVLTPPEPIDDPEDLEPGRHGLII----EKG-GRSGLLLPQVAVEQGWDPEEFLDHLCRKAGLPP--DAW 152
                         170
                  ....*....|....
gi 23943793   266 FRKSIKLTRYRSEK 279
Cdd:pfam01871 153 SDEDIKLYRFEVEV 166
AMMECR1 COG2078
Uncharacterized conserved protein, AMMECR1 domain [Function unknown];
106-257 4.33e-34

Uncharacterized conserved protein, AMMECR1 domain [Function unknown];


Pssm-ID: 224989  Cd Length: 203  Bit Score: 123.21  E-value: 4.33e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793 106 AEMCCYCFDVLYCHLYGFPQPRLPRFT---NDPYPLFVTWKTGR-DKRLRGCIGTFSAM-NLHSGLREYTLTSALKDSRF 180
Cdd:COG2078  11 HPLVRLAREAIENYLEGGKVIEPEPFPklfQEKRGVFVTLEKYSpDGELRGCIGTPEPVkPLAEAIIKAAIEAALSDPRF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793 181 PPLTREELPKLFCSVSLLTNFE----DASDYL-DWEVGVHGIriefINEKGIKRtATYLPEVAKEQDWDQIQTIDSLLRK 255
Cdd:COG2078  91 PPVSLEELDDIVVEVTILTPPEeidvPPEERPeDIEVGRHGL----IVEKGIYS-GLLLPQVPVEYRWDVEEFLEHTCEK 165

                ..
gi 23943793 256 GG 257
Cdd:COG2078 166 AG 167
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
111-258 1.23e-32

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 119.54  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   111 YCFDVLYCHLYGFP----QPRLPRFTNDPYPLFVTWKTGRDKRLRGCIGTFS-AMNLHSGLREYTLTSALKDSRFPPLTR 185
Cdd:TIGR00296  15 YARYAIESHLNGGKssrlYPDLPIVFNEKRGVFITLKKKGNKHLRGCIGTPEpVMPLIEAIEEAAISAATEDPRFPPVQL 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23943793   186 EELPKLFCSVSLLTNFE-----DASDYL-DWEVGVHGIRIEFinekGIKRtATYLPEVAKEQDWDQIQTIDSLLRKGGF 258
Cdd:TIGR00296  95 EELDDIKVEVSILTPPEtifvgGPKDYPfDIEIGRHGLIVEF----GPKR-GLLLPQVAVEYGWDAEEFLANLCMKAGL 168
PRK00801 PRK00801
hypothetical protein; Provisional
124-247 1.10e-11

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 62.77  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793  124 PQPRLPRFTNDPYPLFVTWKtgRDKRLRGCIG-TFSAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNFE 202
Cdd:PRK00801  32 PPKDLPPVFWEKRGVFVTLN--KHGVLRGCIGfPYPDSPLVEAIIDSAISAATRDPRFPPVKLEEMDEITVEVTVLTPPE 109
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 23943793  203 --DAS-----DYLdwEVGVHGIriefINEKGIkRTATYLPEVAKEQDWDQIQ 247
Cdd:PRK00801 110 liEGPpeelpEKI--EVGRHGL----IVKKGI-YSGLLLPQVAPEWGFDSEE 154
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
110-279 1.25e-72

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 334718  Cd Length: 166  Bit Score: 221.15  E-value: 1.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   110 CYCFDVLYCHLYG---FPQPRLPRFTNDPYPLFVTWKTgRDKRLRGCIGTFSA-MNLHSGLREYTLTSALKDSRFPPLTR 185
Cdd:pfam01871   1 RLAREAIESYLKGgkpLPPEDPPPLLNEKRGVFVTLKK-KNGELRGCIGTLEPvRPLAEEIIENAIAAAFRDPRFPPLTP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   186 EELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGiKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKApiTSE 265
Cdd:pfam01871  80 DELPDLEIEVSVLTPPEPIDDPEDLEPGRHGLII----EKG-GRSGLLLPQVAVEQGWDPEEFLDHLCRKAGLPP--DAW 152
                         170
                  ....*....|....
gi 23943793   266 FRKSIKLTRYRSEK 279
Cdd:pfam01871 153 SDEDIKLYRFEVEV 166
AMMECR1 COG2078
Uncharacterized conserved protein, AMMECR1 domain [Function unknown];
106-257 4.33e-34

Uncharacterized conserved protein, AMMECR1 domain [Function unknown];


Pssm-ID: 224989  Cd Length: 203  Bit Score: 123.21  E-value: 4.33e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793 106 AEMCCYCFDVLYCHLYGFPQPRLPRFT---NDPYPLFVTWKTGR-DKRLRGCIGTFSAM-NLHSGLREYTLTSALKDSRF 180
Cdd:COG2078  11 HPLVRLAREAIENYLEGGKVIEPEPFPklfQEKRGVFVTLEKYSpDGELRGCIGTPEPVkPLAEAIIKAAIEAALSDPRF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793 181 PPLTREELPKLFCSVSLLTNFE----DASDYL-DWEVGVHGIriefINEKGIKRtATYLPEVAKEQDWDQIQTIDSLLRK 255
Cdd:COG2078  91 PPVSLEELDDIVVEVTILTPPEeidvPPEERPeDIEVGRHGL----IVEKGIYS-GLLLPQVPVEYRWDVEEFLEHTCEK 165

                ..
gi 23943793 256 GG 257
Cdd:COG2078 166 AG 167
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
111-258 1.23e-32

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 119.54  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   111 YCFDVLYCHLYGFP----QPRLPRFTNDPYPLFVTWKTGRDKRLRGCIGTFS-AMNLHSGLREYTLTSALKDSRFPPLTR 185
Cdd:TIGR00296  15 YARYAIESHLNGGKssrlYPDLPIVFNEKRGVFITLKKKGNKHLRGCIGTPEpVMPLIEAIEEAAISAATEDPRFPPVQL 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23943793   186 EELPKLFCSVSLLTNFE-----DASDYL-DWEVGVHGIRIEFinekGIKRtATYLPEVAKEQDWDQIQTIDSLLRKGGF 258
Cdd:TIGR00296  95 EELDDIKVEVSILTPPEtifvgGPKDYPfDIEIGRHGLIVEF----GPKR-GLLLPQVAVEYGWDAEEFLANLCMKAGL 168
AmmeMemoSam_A TIGR04335
AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain ...
124-279 7.79e-27

AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain family as AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Members of the present family occur as part of a three gene system with a homolog of the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility), and an uncharacterized radical SAM enzyme.


Pssm-ID: 275134  Cd Length: 174  Bit Score: 103.43  E-value: 7.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   124 PQPRLPRFtNDPYPLFVTWKtgRDKRLRGCIGTFSA-MNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLT--- 199
Cdd:TIGR04335  23 LSPGPPKL-NEKGGCFVTLH--KNGELRGCIGTIEAdRPLVEDVAENAIAAAFKDPRFPPLTEDELDRLTIEVSVLSppe 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793   200 --NFEDASDYL-DWEVGVHGIriefINEKGIKRtATYLPEVAKEQDwDQIQTIDSLLRKGGFKApitSEFRKSIKLTRYR 276
Cdd:TIGR04335 100 plPVEDEEELLeELRPGRDGL----ILEDGGRR-GLFLPQVWEELP-DPEEFLRHLCLKAGLPP---DAWRDDVTIYRFT 170

                  ...
gi 23943793   277 SEK 279
Cdd:TIGR04335 171 VEV 173
PRK00801 PRK00801
hypothetical protein; Provisional
124-247 1.10e-11

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 62.77  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793  124 PQPRLPRFTNDPYPLFVTWKtgRDKRLRGCIG-TFSAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNFE 202
Cdd:PRK00801  32 PPKDLPPVFWEKRGVFVTLN--KHGVLRGCIGfPYPDSPLVEAIIDSAISAATRDPRFPPVKLEEMDEITVEVTVLTPPE 109
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 23943793  203 --DAS-----DYLdwEVGVHGIriefINEKGIkRTATYLPEVAKEQDWDQIQ 247
Cdd:PRK00801 110 liEGPpeelpEKI--EVGRHGL----IVKKGI-YSGLLLPQVAPEWGFDSEE 154
PRK03881 PRK03881
hypothetical protein; Provisional
124-214 7.18e-09

hypothetical protein; Provisional


Pssm-ID: 235170 [Multi-domain]  Cd Length: 467  Bit Score: 56.42  E-value: 7.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943793  124 PQPRLPRFTNDPYPLFVTWKtgRDKRLRGCIGTF--SAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNF 201
Cdd:PRK03881 323 PDYLPEEMLNRRAGVFVSLK--KDGELRGCIGTIfpTRENIAEEIIRNAISAGTEDPRFPPVEEDELDDLVYSVDVLTEP 400
                         90
                 ....*....|....*.
gi 23943793  202 EDAS--DYLD-WEVGV 214
Cdd:PRK03881 401 EPVSslDELDpKRYGV 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.17
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH