NCBI Conserved Domain Search

Conserved domains on [gi|22129411|ref|NP_666924|]

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olfactory receptor family 13 subfamily P member 4 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

30-297

3.33e-141

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd15946:

Pssm-ID: 475119 Cd Length: 270 Bit Score: 399.55 E-value: 3.33e-141

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

30-297

3.33e-141

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 399.55 E-value: 3.33e-141

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

34-308

7.49e-48

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 161.90 E-value: 7.49e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411    34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIA 113
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   114 ECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLACA 193
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   194 DTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGSWYDP 271
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 22129411   272 ERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

30-297

3.33e-141

Pssm-ID: 320612 Cd Length: 270 Bit Score: 399.55 E-value: 3.33e-141

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

30-304

9.86e-140

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 396.06 E-value: 9.86e-140

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15225   3 LFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15225  83 LGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15225 163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15225 243 SPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

30-304

7.00e-137

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 388.83 E-value: 7.00e-137

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15421   3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15421  83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

30-297

1.69e-136

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 387.40 E-value: 1.69e-136

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15237   3 LFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15237  83 LGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15237 163 LACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15237 243 SPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-297

5.00e-136

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 386.07 E-value: 5.00e-136

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd13954   3 LFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd13954  83 LGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd13954 163 LSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd13954 243 SSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

28-297

9.12e-129

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 367.99 E-value: 9.12e-129

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15230 241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

28-297

1.13e-125

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 360.00 E-value: 1.13e-125

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIyTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15431 240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

30-304

7.58e-125

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 358.18 E-value: 7.58e-125

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

30-297

3.31e-123

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 353.85 E-value: 3.31e-123

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

30-304

1.83e-120

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 347.08 E-value: 1.83e-120

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

30-304

9.13e-118

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 340.35 E-value: 9.13e-118

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15235   4 LFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15235  84 FGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15235 164 LSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSY 243

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15235 244 SADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

15-301

1.38e-117

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 340.07 E-value: 1.38e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  15 FLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRT 94
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  95 ISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGP 174
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 175 YKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMF 254
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129411 255 YGPAMIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVK 301
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

30-304

1.01e-116

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 337.70 E-value: 1.01e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

30-303

8.96e-116

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 335.12 E-value: 8.96e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGA 276

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

14-308

1.64e-115

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 335.10 E-value: 1.64e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  14 EFLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRR 93
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  94 TISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCG 173
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 174 PYKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTM 253
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129411 254 FYGPAMIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

28-297

2.94e-115

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 333.68 E-value: 2.94e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

30-303

3.14e-115

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 334.01 E-value: 3.14e-115

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGA 276

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

28-306

1.94e-112

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 326.97 E-value: 1.94e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

15-308

2.45e-112

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 327.31 E-value: 2.45e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  15 FLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRT 94
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  95 ISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGP 174
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 175 YKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMF 254
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 255 YGPAMIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

31-297

3.37e-112

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 325.95 E-value: 3.37e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  31 FIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLL 110
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 111 GIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKL 190
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 191 ACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWYD 270
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 22129411 271 PERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

30-297

3.52e-111

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 323.41 E-value: 3.52e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15918   3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15918  83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15918 163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15918 243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

30-304

7.90e-111

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 322.89 E-value: 7.90e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15432   3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15432 243 SHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

28-304

1.87e-110

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 321.85 E-value: 1.87e-110

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15229  81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15229 161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15229 241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

30-297

2.14e-109

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 318.66 E-value: 2.14e-109

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15911   3 LFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15911  83 LAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15911 163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15911 243 SRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

30-297

1.34e-108

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 316.89 E-value: 1.34e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15232   3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15232  83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15232 163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15232 243 SPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

28-306

7.77e-107

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 312.65 E-value: 7.77e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15417   1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15417 241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

28-297

1.58e-106

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 311.61 E-value: 1.58e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15430  81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15430 161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15430 241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

15-306

1.16e-105

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 310.14 E-value: 1.16e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  15 FLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRT 94
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  95 ISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGP 174
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 175 YKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMF 254
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129411 255 YGPAMIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

28-306

8.92e-105

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 307.31 E-value: 8.92e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15419   1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15419 241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

30-306

1.77e-101

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 298.93 E-value: 1.77e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15412   3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15412  83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15412 163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15412 243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

15-308

3.12e-101

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 299.01 E-value: 3.12e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  15 FLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRT 94
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  95 ISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGP 174
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 175 YKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMF 254
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 255 YGPAMIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

28-312

7.21e-101

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 297.80 E-value: 7.21e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15414 161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVLGDRG 312
Cdd:cd15414 241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

28-297

7.37e-101

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 296.89 E-value: 7.37e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15224   1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15224  81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15224 161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15224 241 ISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

30-304

8.41e-100

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 294.48 E-value: 8.41e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15234   3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15234  83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15234 163 LACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15234 243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

28-306

3.87e-99

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 293.12 E-value: 3.87e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

19-308

1.49e-98

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 291.96 E-value: 1.49e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  19 GFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWG 98
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  99 ACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKIN 178
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 179 HFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPA 258
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 259 MIMYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

30-297

2.83e-98

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 290.36 E-value: 2.83e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRI-RSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSW 268
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                       250       260
                ....*....|....*....|....*....
gi 22129411 269 YDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

28-306

3.35e-98

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 290.76 E-value: 3.35e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15413  81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15413 161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15413 241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

28-303

7.01e-98

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 289.76 E-value: 7.01e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15428   1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15428  81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15428 161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15428 241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHA 276

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

28-306

4.02e-97

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 287.77 E-value: 4.02e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

28-306

3.05e-95

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 283.14 E-value: 3.05e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFIL-GFIFLLVPLSlILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPG 266
Cdd:cd15409 161 LKISCTDPSINELVLFIFsGSIQVFTILT-VLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPS 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 22129411 267 SWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15409 240 SLYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

28-306

4.34e-95

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 282.77 E-value: 4.34e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLK 306
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

30-303

7.15e-95

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 282.07 E-value: 7.15e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGA 276

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

28-304

1.16e-94

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 281.63 E-value: 1.16e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 268 wyDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15228 241 --SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

30-303

1.29e-94

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 281.68 E-value: 1.29e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

30-303

7.39e-92

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 274.33 E-value: 7.39e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPR-RTISWGACVAQMFIFL 108
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSw 268
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS- 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 269 yDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15916 242 -KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTA 275

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

29-297

9.48e-91

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 271.38 E-value: 9.48e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  29 ALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFL 108
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLACADTsfnDRLDFIL----GFIFLLVPLSLILaSYACIFASIlRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMR 264
Cdd:cd15226 162 KLACTDT---YVLELMVvansGLISLVCFLLLLI-SYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVW 236

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129411 265 PGSWYdpERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15226 237 PFSTF--PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

30-297

4.42e-90

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 269.63 E-value: 4.42e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

30-297

7.62e-90

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 269.08 E-value: 7.62e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15939  83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASiLRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15939 163 LACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 dPErDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15939 242 -PI-DKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

27-307

8.54e-90

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 269.34 E-value: 8.54e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  27 RVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFI 106
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPA 186
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 187 VLKLACADT-SFNDRLDFILGFIfLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRP 265
Cdd:cd15418 161 LVKLACDDTrVYELILYFILGFN-VIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRP 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129411 266 GSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKV 307
Cdd:cd15418 240 SSSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

31-303

3.47e-89

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 267.79 E-value: 3.47e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  31 FIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLL 110
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 111 GIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKL 190
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 191 ACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWYD 270
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                       250       260       270
                ....*....|....*....|....*....|...
gi 22129411 271 PERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGA 276

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

30-297

7.58e-88

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 263.79 E-value: 7.58e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

28-297

5.26e-87

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 261.61 E-value: 5.26e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASiLRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15940 161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYdpERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15940 240 SF--SEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

30-303

4.79e-84

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 254.67 E-value: 4.79e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFI-LGFIFLLVPLsLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSW 268
Cdd:cd15942 163 LACADTAFNELVTFIdIGLVAMTCFL-LILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 269 yDPeRDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15942 242 -DP-LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDA 274

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

30-304

3.59e-81

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 247.45 E-value: 3.59e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHT-PMYFFLSILSLVDMSYVTTTVPQMLVNMVCPR-RTISWGACVAQMFIF 107
Cdd:cd15941   3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15941 163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 268 wyDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15941 243 --SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

30-303

2.73e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 245.02 E-value: 2.73e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSWY 269
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGA 303
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLA 276

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

30-297

6.80e-79

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 241.08 E-value: 6.80e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15936   3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTS-------FNDRLDFILGFIFLLVPLSLILAsyacifasILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMY 262
Cdd:cd15936 163 LACTDTFllellmvSNSGLVTLLIFFILLISYTVILV--------KIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIY 234

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 263 MRPGSWYDPerDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15936 235 ARPFQTFPM--DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

28-297

3.51e-75

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 231.69 E-value: 3.51e-75

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15938   1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15938  81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIfasILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15938 161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFS 237

                       250       260       270
                ....*....|....*....|....*....|
gi 22129411 268 WYdpERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15938 238 TF--PVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

30-297

1.92e-68

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 214.22 E-value: 1.92e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15937  83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASiLRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPgsWY 269
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--FR 239

                       250       260
                ....*....|....*....|....*...
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15937 240 SFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

30-297

6.00e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 213.09 E-value: 6.00e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRL-HTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFL 108
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASiLRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPGSw 268
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS- 240

                       250       260
                ....*....|....*....|....*....
gi 22129411 269 yDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd15935 241 -SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

32-298

1.44e-63

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 202.13 E-value: 1.44e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15917   5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLA 191
Cdd:cd15917  85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGSWY 269
Cdd:cd15917 165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHHV 244

                       250       260
                ....*....|....*....|....*....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNK 298
Cdd:cd15917 245 PPHVHILLANLYLLLPPMLNPIVYGVRTK 273

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

30-304

3.87e-63

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 200.98 E-value: 3.87e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15223  83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGS 267
Cdd:cd15223 163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGK 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15223 243 TIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

30-298

3.60e-60

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 193.49 E-value: 3.60e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAEC-VLYAiMAYDRYVAICFPLHYSVLM--SRLVCIKMVTVCWSISITGALIYTVFtmRLPYCGPYKINHFFCEVPA 186
Cdd:cd15222  83 FSFMESsVLLA-MAFDRFVAICNPLRYASILtnSRIAKIGLAIVLRSVLLLLPLPFLLK--RLPFCHSNVLSHSYCLHQD 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 187 VLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPaMI---MYM 263
Cdd:cd15222 160 VMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVP-MIglsMVH 238

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 264 RPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNK 298
Cdd:cd15222 239 RFGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTK 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

32-300

5.52e-60

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 193.01 E-value: 5.52e-60

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15950   5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVcwsISITGALIYTVFTM---RLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15950  85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLA---IVLRALLFMTPLTClvtSLPYCGSRVVPHSYCEHMAVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMI-MYM-RPG 266
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTqRFG 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 267 SWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15950 242 QGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

32-298

4.37e-59

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 190.58 E-value: 4.37e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15221   5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCW--SISITGALIYtvFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15221  85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVarSFCIVFPFVF--LLKRLPYCGHNVIPHTYCEHMGIAR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAM--IMYMRPGS 267
Cdd:cd15221 163 LACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFfsFLTHRFGR 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 22129411 268 WYDPERDKKLALFYNVVSAFLNPIIYSLRNK 298
Cdd:cd15221 243 HIPRHVHILLANLYVLVPPMLNPIVYGVKTK 273

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

32-298

8.54e-56

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 182.08 E-value: 8.54e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15953   5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLS 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLA 191
Cdd:cd15953  85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGSWY 269
Cdd:cd15953 165 CGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGI 244

                       250       260
                ....*....|....*....|....*....
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNK 298
Cdd:cd15953 245 APHIHIILANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

34-300

9.00e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 182.19 E-value: 9.00e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIA 113
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 114 ECVLYAIMAYDRYVAICFPLHYSVLMS--RLVCIKMVTVCWSISITGALIYtvFTMRLPYCGPYKINHFFCEVPAVLKLA 191
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTnkVISVIALGIVLRPLLLVLPFVF--LILRLPFCGHNIIPHTYCEHMGIAKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADTSFNdrLDFILGFI-FLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGSW 268
Cdd:cd15952 165 CASIRIN--IIYGLFAIsVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHN 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 22129411 269 YDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15952 243 IPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

28-300

2.12e-54

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 178.69 E-value: 2.12e-54

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVcwsISITGALIYTVFTM---RLPYCGPYKINHFFCEV 184
Cdd:cd15951  81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLA---VVLRGGILVSPHPFllrRLPYCRTNIIPHTYCEH 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 185 PAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM- 263
Cdd:cd15951 158 MAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLt 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129411 264 -RPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15951 238 hRFGHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

32-301

5.41e-49

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 164.69 E-value: 5.41e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15948   6 IPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLA 191
Cdd:cd15948  86 IMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMI--MYMRPGSWY 269
Cdd:cd15948 166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLssTMHRFARHV 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 22129411 270 DPERDKKLALFYNVVSAFLNPIIYSLRNKDVK 301
Cdd:cd15948 246 APHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

13-301

5.80e-48

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 162.25 E-value: 5.80e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  13 SEFLLLGFSSESQVRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPR 92
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  93 RTISWGACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYC 172
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 173 GPYKINHFFCEVPAVLKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVT 252
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129411 253 MFYGPAMI--MYMRPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVK 301
Cdd:cd15949 242 AFYVPIAVssLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

34-308

7.49e-48

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 161.90 E-value: 7.49e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411    34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIA 113
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   114 ECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLACA 193
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   194 DTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPGSWYDP 271
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 22129411   272 ERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-300

5.42e-46

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 156.95 E-value: 5.42e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15956   3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLM--SRLVCIKMVTVCWSISITGAliYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15956  83 FSAMESGVLVAMALDRFVAICNPLHYATILtlEVVAKAGLLLALRGVAIVIP--FPLLVCRLSFCASHTIAHTYCEHMAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RP 265
Cdd:cd15956 161 VKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129411 266 GSWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15956 241 GHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

32-300

1.83e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 139.90 E-value: 1.83e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15955   5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQ 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKM---VTVCWSISITGALIytVFTMRLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15955  85 AFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIgvlVVVRAVVLIIPCPL--LIKLRLHHFRSTVISHSYCEHMAVV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLACADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYM--RPG 266
Cdd:cd15955 163 KLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFG 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 267 SWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15955 243 HHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

34-300

7.20e-38

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 135.72 E-value: 7.20e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIA 113
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 114 ECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLACA 193
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 194 dtsfNDRLDFILGFIFLLV----PLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMR---PG 266
Cdd:cd15954 167 ----NIRVDAIYGLMVALLiggfDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfGG 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 22129411 267 SWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDV 300
Cdd:cd15954 243 HHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

44-293

1.43e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 118.55 E-value: 1.43e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411    44 GNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRR-TISWGACVAQMFIFLLLGIAECVLYAIMA 122
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   123 YDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPykiNHFFCEVPAVLKLACadtsfNDRLD 202
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411   203 FILGFIFLLVPLSLILASYACIFASILRIRSSQGRL-------KSFSTCASHITVVTMFYGPAMIMYMRPGSWYDPERDK 275
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 22129411   276 ------KLALFYNVVSAFLNPIIY 293
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

30-297

4.65e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 101.60 E-value: 4.65e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCevpavlk 189
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 lacaDTSFNDRLDFILGFIFLLVPLSLILASYACIFASILR--------------IRSSQGRLKSFSTCASHITVVTMFY 255
Cdd:cd00637 154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCW 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129411 256 GPAMIMYM----RPGSWYDPERDKKLALFYNVVSAFLNPIIYSLRN 297
Cdd:cd00637 230 LPYFILLLldvfGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-304

3.49e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 82.23 E-value: 3.49e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIytvftmrlpycgPYKINHFFCEVPAVLK 189
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP------------PLVGWRDETQPSVVDC 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACadTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRirssqgRLKSFSTCAshiTVVTMFY---GPAMIMYMRpg 266
Cdd:cd14967 150 ECE--FTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLlcwLPFFIIYLV-- 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129411 267 SWYDPERDKKLALFYNV-----VSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd14967 217 SAFCPPDCVPPILYAVFfwlgyLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

32-304

1.05e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 61.07 E-value: 1.05e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIkMVTVCWsisitgalIYTVFTMRLPYCGpykINHFfceVPAVLKLA 191
Cdd:cd14969  85 LVSISTLAALAFERYLVIVRPLKAFRLSKRRALI-LIAFIW--------LYGLFWALPPLFG---WSSY---VPEGGGTS 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CA----DTSFNDRLDFILGFIF-LLVPLSLILASYACIFASILRIRSSQGRLKSFSTCAS----HITVVTMFYgpAMIM- 261
Cdd:cd14969 150 CSvdwySKDPNSLSYIVSLFVFcFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkkaEKKVAKMVL--VMIVa 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22129411 262 -------YMRPGSWYDPERDKKLALFYNVVSAFL-------NPIIYSLRNKDVKGAF 304
Cdd:cd14969 228 fliawtpYAVVSLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

32-304

1.93e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 60.38 E-value: 1.93e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALiytvftmrLPYCGpykINHFFCEVPAVLKLA 191
Cdd:cd14972  83 ASAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLG---WNCVLCDQESCSPLG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADTsfndRLDFILGFIFLLVPLSLILASYACIFASILRiRSSQGRLKSFSTCASH--------ITVVTMF------YGP 257
Cdd:cd14972 151 PGLP----KSYLVLILVFFFIALVIIVFLYVRIFWCLWR-HANAIAARQEAAVPAQpstsrklaKTVVIVLgvflvcWLP 225

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 258 AMIMYMRPGSWYDPERDKK---LALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd14972 226 LLILLVLDVLCPSVCDIQAvfyYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

28-156

1.16e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 58.33 E-value: 1.16e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsYVTTTVpqMLVNMVcprRTIS--W----GACV 101
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADF-LVGLLV--MPFSMI---RSIEtcWyfgdTFCK 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129411 102 AQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd15055  75 LHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSA 129

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

35-308

7.92e-09

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 55.73 E-value: 7.92e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIAE 114
Cdd:cd15307   8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 115 CVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCgpyKINHFFCEVPAVLklacad 194
Cdd:cd15307  88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHAS---VLVNGTCQIPDPV------ 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 195 tsfndrLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMF-----YGPAMIMYMRPGSWY 269
Cdd:cd15307 159 ------YKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPTVCA 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22129411 270 DPERDKKLALFYNVV-----SAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15307 233 ECEERISHWVFDVVTwlgyaSSMVNPIFYTIFNKVFRQAFKKVL 276

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

28-230

4.05e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 53.49 E-value: 4.05e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWsisitgalIYTVFTMRLPYCGPYKInhffceVPAV 187
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVW--------LYSLLWVLPPLFGWSRY------VLEG 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129411 188 LKLACA----DTSFNDRLDFILGFIF-LLVPLSLILASYACIFASILR 230
Cdd:cd15083 147 LLTSCSfdylSRDDANRSYVICLLIFgFVLPLLIIIYCYSFIFRAVRR 194

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

29-304

4.44e-08

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 53.09 E-value: 4.44e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  29 ALFIFFLLLymITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVP-QMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15052   4 ALLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPycgpykinhffceVPAV 187
Cdd:cd15052  82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT-------------TNVL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACAdtsFNDRLDFILGFIF-LLVPLSLILASYAcifasiLRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMRPG 266
Cdd:cd15052 149 NNGTCV---LFNPNFVIYGSIVaFFIPLLIMVVTYA------LTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTG 219

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129411 267 -----SWYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15052 220 lceecNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

32-304

7.04e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 52.60 E-value: 7.04e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMV------CPRRTiswgaCVAQMF 105
Cdd:cd15305   5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILydyawpLPRYL-----CPIWIS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 106 IFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITgaliytvFTMRLPYCGPYKINHFFCEVP 185
Cdd:cd15305  80 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG-------ISMPIPVIGLQDDEKVFVNGT 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 186 AVLklacadtsfNDRLDFILG-FIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYGPAMIMYMR 264
Cdd:cd15305 153 CVL---------NDENFVLIGsFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNIL 223

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129411 265 PGSWYDPERDKKLALFYNV------VSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15305 224 SVLCKEACDQKLMEELLNVfvwvgyVSSGINPLVYTLFNKTYRRAF 269

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

31-304

1.87e-07

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 51.51 E-value: 1.87e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  31 FIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLL 110
Cdd:cd15001   3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 111 GIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGA--LIYTVFTMRLPYCGPYKINHFFCEVPAVL 188
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAspVLFGQGLVRYESENGVTVYHCQKAWPSTL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 189 KLacadtsfndRLDFILGFIFL-LVPLSLILASYACIfasilrirssqGRLKSFSTCASHITVVTMFYGPAMIMYMRPGS 267
Cdd:cd15001 163 YS---------RLYVVYLAIVIfFIPLIVMTFAYARD-----------TRKQVIKMLISVVVLFAVCWGPLLIDNLLVSF 222

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22129411 268 WYDPERD----KKLALFYNVVSAF---LNPIIYSLRNKDVKGAF 304
Cdd:cd15001 223 DVISTLHtqalKYMRIAFHLLSYAnscINPIIYAFMSKNFRSSF 266

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

31-304

2.14e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 51.49 E-value: 2.14e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  31 FIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTIS---WGACVAQMF-- 105
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNFHgclFMACLVLVLtq 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 106 --IFLLLGIaecvlyaimAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS-ITGALIYTVFTMRLPYCGPYKINHFFC 182
Cdd:cd14968  84 ssIFSLLAI---------AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSfLVGLTPMFGWNNGAPLESGCGEGGIQC 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 183 EVPAVLklacadtsfndRLDFILGFIF---LLVPLSLILASYACIF----------ASILRIRSSQGRLKSFSTCASHIT 249
Cdd:cd14968 155 LFEEVI-----------PMDYMVYFNFfacVLVPLLIMLVIYLRIFrvirkqlrqiESLLRSRRSRSTLQKEVKAAKSLA 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129411 250 VVTMFYG----PAMIM----YMRPGSwYDPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd14968 224 IILFLFAlcwlPLHIIncitLFCPEC-KVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

28-235

4.13e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 50.43 E-value: 4.13e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRrtiSW----GACVAQ 103
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQY---PWafgdGGCKLY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 104 MFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTvFTMRLPYcgPYKINHFFCE 183
Cdd:cd14979  78 YFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPIL-FLMGIQY--LNGPLPGPVP 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129411 184 VPAVLKLACADTSFNDRLDFILgFIFLLVPLSLILASYACIFASILRIRSSQ 235
Cdd:cd14979 155 DSAVCTLVVDRSTFKYVFQVST-FIFFVLPMFVISILYFRIGVKLRSMRNIK 205

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-304

8.30e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 49.28 E-value: 8.30e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15061   2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISItgaliytvFTMRLPYCGPYKinhffcEVPAVLK 189
Cdd:cd15061  82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVGPSW------HGRRGLG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFIFLlvPLSLILASYACIFASILRIRssqgrlKSFSTCASHITVVTMFYGPAMIMY-MRPGSW 268
Cdd:cd15061 148 SCYYTYDKGYRIYSSMGSFFL--PLLLMLFVYLRIFRVIAKER------KTAKTLAIVVGCFIVCWLPFFIMYlIEPFCD 219

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 269 YDPERD-KKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15061 220 CQFSEAlSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

28-156

8.78e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 49.66 E-value: 8.78e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15312   1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd15312  81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPC 129

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

30-239

9.00e-07

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 49.36 E-value: 9.00e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLL 109
Cdd:cd15012   2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPykiNHFFCEVPAVLK 189
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVT---QDGQEEEICVLD 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 190 LACADTSFNDRLDFILGFiflLVPLSLILASYACIFASILRIRSSQGRLK 239
Cdd:cd15012 159 REMFNSKLYDTINFIVWY---LIPLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

32-304

1.04e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 49.39 E-value: 1.04e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd14971   5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISItgaliytvfTMRLPYCGPYKINHFFCEVPAVLKLA 191
Cdd:cd14971  85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSL---------AVAAPVLALHRLRNYTPGNRTVCSEA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 192 CADtSFNDRLDFILGFIFL-LVPLSLILASYACIFASILRI--------RSSQGRLKSFSTCASHITVVTMFYGPAMIMY 262
Cdd:cd14971 156 WPS-RAHRRAFALCTFLFGyLLPLLLICVCYAAMLRHLWRVavrpvlseGSRRAKRKVTRLVLVVVVLFAACWGPIHAIL 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 263 MRpgSWYDPERDKKLALFYNVVSAFL-------NPIIYSLRNKDVKGAF 304
Cdd:cd14971 235 LL--VALGPFPLTYATYALRIWAHCLaysnsavNPVLYAFLSEHFRKAF 281

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

36-160

1.18e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 49.38 E-value: 1.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMlvnMVCPRRTISW--GACVAQMFIFL--LLG 111
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFV---MASVRHGSGWiyGALSCKVIAFLavLFC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 112 IAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAL 160
Cdd:cd15005  86 FHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

30-297

4.20e-06

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 47.42 E-value: 4.20e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM-SYVTTTVPQMLVNMVcPRRTISWGACVAQMFIFL 108
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLlASLVVLVLFFLLGLT-EASSRPQALCYLIYLLWY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS-ITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd14964  80 GANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSlLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACadtsfndrldfilgFIFLLVPLSLILASYACIF----ASILRIRSSQGR-----LKSFSTCASHITVVTMFYGPA 258
Cdd:cd14964 160 TWGFL--------------LVSFLLPLVAFLVIFSRIVlrlrRRVRAIRSAASLntdknLKATKSLLILVITFLLCWLPF 225

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129411 259 MIMYMRPGSWYDPERDKKLALFYN---VVSAFLNPIIYSLRN 297
Cdd:cd14964 226 SIVFILHALVAAGQGLNLLSILANllaVLASTLNPFIYCLGN 267

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

35-304

5.05e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 47.23 E-value: 5.05e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRR-TISWGACVAQMFIFLLLGIA 113
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 114 ECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITgaliytvFTMRLPYCGPYKINHFFCEVPAVLklacA 193
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVG-------ISMPIPVFGLQDDSKVFKEGSCLL----A 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 194 DTSFNdrldFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVT---MFYGPAMIMYMRPGSwyD 270
Cdd:cd15304 157 DENFV----LIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMwcpFFITNVMAVICKESC--N 230

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129411 271 PERDKKLA---LFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15304 231 EVVIGGLLnvfVWIGYLSSAVNPLVYTLFNKTYRSAF 267

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

28-163

1.32e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 45.90 E-value: 1.32e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSI--SITGALIYT 163
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVpgIYTFGLIYT 138

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

32-171

2.00e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 45.25 E-value: 2.00e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGAC-VAQMFIFLLL 110
Cdd:cd15978   5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCkTATYFMGISV 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129411 111 GIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPY 171
Cdd:cd15978  85 SVSTFNLVAI-SLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

34-165

2.18e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 45.17 E-value: 2.18e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM----SYVTTTVPQMLVN---MVCPRRTISWGACVAQMFI 106
Cdd:cd15351   7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMlvsvSNLIETLFMLLLEhgvLVCRAPMLQHMDNVIDTMI 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 22129411 107 FLLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVF 165
Cdd:cd15351  87 CSSVVSSLSFLGAI-AVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

34-166

2.19e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 45.31 E-value: 2.19e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM-SYVTTTVPQMLVNMVCPRRTISWGACVAQM------FI 106
Cdd:cd15354   7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMlVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsLI 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFT 166
Cdd:cd15354  87 CISVVASMCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYS 145

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

28-304

2.20e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 45.01 E-value: 2.20e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTIswGACVAQMFIF 107
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWIL--GQVLCDIWIS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 L--LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIyTVFTMRlpycGPYKINHFFCEVp 185
Cdd:cd15064  79 LdvTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP-PLFGWR----TPDSEDPSECLI- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 186 avlklacadtSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRssqgrlKSFSTCASHITVVTM----FYGPAMIM 261
Cdd:cd15064 153 ----------SQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAARER------KAAKTLGIILGAFIVcwlpFFLVALIV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129411 262 YMRPGSWYdPERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15064 217 PLCSHCWI-PLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

28-304

2.53e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 45.07 E-value: 2.53e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGAC-VAQMFI 106
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCkLIPYFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKinhffCEVPA 186
Cdd:cd15206  81 AVSVSVSTFTLVAI-SLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG-----HKCRE 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 187 VLKLACADTSFNDRLDFILgfifLLVPLSLILASYACIFASILRIRSSQGRL-----KSFSTCASHITVVT---MFYGPA 258
Cdd:cd15206 155 VWPNEIAEQAWYVFLDLML----LVIPGLVMSVAYGLISWTLLEAKKRVIRMlfvivVEFFICWTPLYVINtwkAFDPPS 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129411 259 MIMYMRPGSWydperdkKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15206 231 AARYVSSTTI-------SLIQLLAYISSCVNPITYCFMNKRFRQAF 269

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

36-160

3.55e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 44.94 E-value: 3.55e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMvcpRRTISWGACVAQMFIFLLLGIAEC 115
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSI---RNGSAWTYSVLSCKIVAFMAVLFC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 116 VLYAIMAY----DRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAL 160
Cdd:cd15217  86 FHAAFMLFcisvTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAF 134

7tmA_Histamine_H4R

cd15295

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...

28-308

3.82e-05

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320422 [Multi-domain] Cd Length: 267 Bit Score: 44.43 E-value: 3.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRL-HTPMYFFLSiLSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFI 106
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLrHRSNYFFLN-LAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAIMAYDRYVAICFPLHYSVlmsrlvciKMVTVCWSISITGALIYTVFTMRLPYCgpykinhFFCEVPA 186
Cdd:cd15295  80 DYLLCTASVYNIVLISYDRYQSVSNAVSYRN--------QQTATLRIVTQMVAVWVLAFLVHGPAI-------LVSDSWK 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 187 VLKLAC-ADTSFNDRLDFILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKS-------FSTCASHITVVTMFYgpA 258
Cdd:cd15295 145 TEDGECePEFFSNWYILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRDRKLAKSlaiilgtFAICWAPYSLFTIIR--A 222

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 259 MIMYMRPGSWYdperdkKLALFYNVVSAFLNPIIYSLRNKDVKGAFLKVL 308
Cdd:cd15295 223 ACEKHRGSPWY------NFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

28-304

4.10e-05

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 44.34 E-value: 4.10e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISitgaliytvFTMRLPYCGpykINHFFCEVPAV 187
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS---------FLWVIPILG---WHHFARGGERV 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLACADTSFNDRLDF--ILGFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCashitvVTMFYGPAMIMYMRP 265
Cdd:cd15050 149 VLEDKCETDFHDVTWFkvLTAILNFYIPSLLMLWFYAKIFKAVNRERKAAKQLGFIMAA------FILCWIPYFILFMVI 222

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129411 266 GSWYD--PERDKKLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15050 223 AFCKNccNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

29-224

4.35e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 44.35 E-value: 4.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  29 ALFI-FFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRrtiSW----GACvaq 103
Cdd:cd15394   1 PLIIpLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPR---GWvfgrFMC--- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 104 MFIFLLLGIAECV----LYAImAYDRYVAICFPLHYSvlMSRLVCIKMVTVCWSISITGALiytvftmrlpycgPYKINH 179
Cdd:cd15394  75 YFVFLMQPVTVYVsvftLTAI-AVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLAL-------------PAAAHT 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 180 FFCEVPAVLKLACADTSFN---DRLDFILGFIFL--LVPLSLILASYACI 224
Cdd:cd15394 139 YYVEFKGLDFSICEEFWFGqekQRLAYACSTLLItyVLPLLAISLSYLRI 188

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

30-160

4.88e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 44.10 E-value: 4.88e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  30 LFIFFLLLYMITLLGNGLIItLIYLDSR-LHTPMYFFLSILSLVDMSYVTTTvPQMLVNmvCPRRTISWGACVAQMFIFL 108
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVI-YIFSTTKsLRTPSNMLVVNLAISDFLMMIKM-PIFIYN--SFYEGWALGPLGCQIYAFL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 109 --LLGIAECVLYAIMAYDRYVAICFPLHySVLMSRLVCIKMVTVCWSISITGAL 160
Cdd:cd15079  79 gsLSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWAL 131

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

28-253

5.21e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 44.00 E-value: 5.21e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTtVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15094   1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIG-LPFLIVTMILKYWPFGAAMCKIYMVLT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15094  80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAV 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129411 188 lklaCADTSFNdRLDFILGFiflLVPLSLILASYACIfasILRIRSSQGRLKSFSTCASHITVVTM 253
Cdd:cd15094 160 ----NGQKAFT-LYTFLLGF---AIPLLLISVFYTLV---ILRLRTVGPKNKSKEKRRSHRKVTRL 214

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

34-166

5.38e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 44.11 E-value: 5.38e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM-SYVTTTVPQMLVNMVCPRRTISWGACVAQM------FI 106
Cdd:cd15352   7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMlVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsMI 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFT 166
Cdd:cd15352  87 CISLVASICNLLAI-AVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYS 145

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

35-304

5.68e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 44.16 E-value: 5.68e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVnmvcprrtISWGACVA-------QMFIF 107
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--------ISTGFCAAchgclfiACFVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALiytvfTMRLPY--CGPYKINHFFCEVP 185
Cdd:cd15068  80 VLTQSSIFSLLAI-AIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGL-----TPMLGWnnCGQPKEGKNHSQGC 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 186 AVLKLAC--ADTSFNDRLDFILGFIFLLVPLSLILASYACIFASI--------------LRIRSSQGR----LKS----- 240
Cdd:cd15068 154 GEGQVAClfEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAArrqlkqmesqplpgERARSTLQKevhaAKSlaiiv 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129411 241 --FSTCASHITVVTMF--------YGPAMIMYmrpgswydperdkkLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15068 234 glFALCWLPLHIINCFtffcpdcsHAPLWLMY--------------LAIVLSHTNSVVNPFIYAYRIREFRQTF 293

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

32-304

6.01e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 43.85 E-value: 6.01e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVtttvpqmLVNMVcPRRTIS-------WG--ACVA 102
Cdd:cd15337   5 IYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFS-------AVNGF-PLKTISsfnkkwiWGkvACEL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 103 QMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALiytvftmrLPYCGpykinhFFC 182
Cdd:cd15337  77 YGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFG------WGR 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 183 EVPAVLKLACA----DTSFNDRLD----FILGFIFllvPLSLILASYACIFASILR----------------IRSSQGRL 238
Cdd:cd15337 143 YVPEGFQTSCTfdylSRDLNNRLFilglFIFGFLC---PLLIIIFCYVNIIRAVRNhekemtqtaksgmgkdTEKNDARK 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22129411 239 KS-FSTCASHITVVTMF---YGP----AMIMYMRPGSWYDPERDKKLALFYNvVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15337 220 KAeIRIAKVAIILISLFllsWTPyavvALLGQFGPAYWITPYVSELPVMFAK-ASAIYNPIIYALSHPKFRAAL 292

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

34-166

8.47e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 43.25 E-value: 8.47e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM----SYVTTTVPQMLVNM--VCPRR--TISWGACVAQMF 105
Cdd:cd15103   7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMlvsvSNALETIVIILLNNgyLVPRDsfEQHIDNVIDSMI 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129411 106 IFLLLGiAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFT 166
Cdd:cd15103  87 CSSLLA-SICSLLAI-AVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYS 145

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

28-224

8.60e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 43.36 E-value: 8.60e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFif 107
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPY-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 lLLGIAECV----LYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCW----SISITGALIYTVFTMRLPYcgPYKINH 179
Cdd:cd14993  79 -LQGVSVSAsvltLVAI-SIDRYLAICYPLKARRVSTKRRARIIIVAIWviaiIIMLPLLVVYELEEIISSE--PGTITI 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129411 180 FFC-EV--PAVLKLAcadtsfndrLDFILGFIFLLVPLSLILASYACI 224
Cdd:cd14993 155 YICtEDwpSPELRKA---------YNVALFVVLYVLPLLIISVAYSLI 193

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

28-304

9.48e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 43.47 E-value: 9.48e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNmVCPRRTISWGACVAQMFIF 107
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYT-IWQQYPWVFGEVFCKLRAF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAY--DRYVAICFPLHySVLMSRLV-CIKMVTVCWSISITGAliytvftmrLPYCGPYKINHFfcEV 184
Cdd:cd15134  80 LSEMSSYASVLTITAFsvERYLAICHPLR-SHTMSKLSrAIRIIIAIWIIAFVCA---------LPFAIQTRIVYL--EY 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 185 PAVLKLACADTSF---NDRLDFIL------GFIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASHIT------ 249
Cdd:cd15134 148 PPTSGEALEESAFcamLNEIPPITpvfqlsTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQsrrtvl 227

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129411 250 ------VVTMFYGPA-----MIMYMRPGSWYDPERDKKLALFY-----NVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15134 228 rmlvavVVAFFICWApfhaqRLLTVYAKNMTPPYLFINRILFYisgvlYYVSSTVNPILYNVMSAKYRQAF 298

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

26-157

1.15e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 42.86 E-value: 1.15e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  26 VRVALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMF 105
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129411 106 IFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISIT 157
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISIS 134

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

32-156

1.54e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 42.62 E-value: 1.54e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIItLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQML-----VNMVCPRRTISWGACVAQMFI 106
Cdd:cd14978   5 YVLPVICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLlpyiaDYSSSFLSYFYAYFLPYIYPL 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSL 133

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

34-166

1.56e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 42.59 E-value: 1.56e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  34 FLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDM----SYVTTTVPQMLVNMVCPRR---TISWGACVAQMFI 106
Cdd:cd15353   7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMlvsvSNGSETVVITLLNGNDTDAqsfTVNIDNVIDSVIC 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 107 FLLLGiAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFT 166
Cdd:cd15353  87 SSLLA-SICSLLSI-AVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYS 144

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

28-156

1.77e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 42.48 E-value: 1.77e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLymITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15054   3 VAAFLCLIIL--LTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAA 129

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

28-156

1.81e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 42.50 E-value: 1.81e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15301   1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd15301  81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISL 129

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

28-155

2.04e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 42.44 E-value: 2.04e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15058   1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15058  81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVS 128

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

36-236

2.11e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 42.07 E-value: 2.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPqmLVNMVCPRRTISWGACVAQMFIFLLLGIAEC 115
Cdd:cd15070   9 LIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 116 VLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPYCGPYKINHFFCEVPAVLKLacadt 195
Cdd:cd15070  87 MSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM----- 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22129411 196 sfnDRLDFILGFIFLLVPLSLILASYACIFaSILRIRSSQG 236
Cdd:cd15070 162 ---DYMVYFSFFTWILIPLVIMCALYVDIF-YIIRNKLSQN 198

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

32-254

3.39e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 41.64 E-value: 3.39e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLI---YLDSRLHTPMYFFLSiLSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFL 108
Cdd:cd15098   5 VVFGLIFCLGVLGNSLVITVLarvKPGKRRSTTNVFILN-LSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFT 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFtmRLPYCGPYKINHFFC----EV 184
Cdd:cd15098  84 VSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVH--QDLVHHWTASNQTFCwenwPE 161

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129411 185 PAVLKLACADTsfndrldFILGFiflLVPLSLILASYACIFASI---LRIRSSQGRLKSFSTCASHITVVTMF 254
Cdd:cd15098 162 KQQKPVYVVCT-------FVFGY---LLPLLLITFCYAKVLNHLhkkLKNMSKKSERSKKKTAQTVLVVVVVF 224

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

28-304

3.87e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 41.42 E-value: 3.87e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAlIYTVFTMRLPYCGPYKINHFFCEVPAV 187
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVIS-IGPLFGWKEPAPEDETICQITEEPGYA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 188 LKLAcadtsfndrldfiLGFIFLlvPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVTMFYgpamIMYMRPGS 267
Cdd:cd15325 160 LFSA-------------LGSFYL--PLAIILVMYCRVYVVALKFSREKKAAKTLGIVVGCFVLCWLPF----FLVMPIGS 220

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129411 268 WYDPERDK----KLALFYNVVSAFLNPIIYSLRNKDVKGAF 304
Cdd:cd15325 221 IFPAYKPSdtvfKITFWLGYFNSCINPIIYPCSSQEFKKAF 261

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

28-155

4.09e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 41.46 E-value: 4.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsYVTTTVpqMLVNMVCPRRTiSWG----ACVAQ 103
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADL-LVGGLV--MPPSMVRSVET-CWYfgdlFCKIH 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129411 104 MFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15314  77 SSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVS 128

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

28-304

4.37e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 41.12 E-value: 4.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNmVCPRRTISWGACVAQMFIF 107
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVE-TWAREPWLLGEFMCKLVPF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMA--YDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMrlpycgpYKINHFFCEVP 185
Cdd:cd14997  80 VELTVAHASVLTILAisFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITE-------FKEEDFNDGTP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 186 AVLKLACADTSFndRLDFILG--FIFLLVPLSLILASYACIFASILRIRSSQGRLKSFSTCASH----------ITVVTM 253
Cdd:cd14997 153 VAVCRTPADTFW--KVAYILStiVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAANRHTLrsrrqvvymlITVVVL 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129411 254 FY---GPAMIMYMrpGSWYDPERDKK---LALFYNVVS---------AFLNPIIYSLRNKDVKGAF 304
Cdd:cd14997 231 FFvclLPFRVVTL--WIIFAPDEDLQalgLEGYLNLLVfcrvmvylnSALNPILYNLMSTKFRSAF 294

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

28-182

4.38e-04

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 41.30 E-value: 4.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISIT-GALIYTVFTMRLPYCGPYKINHFFC 182
Cdd:cd15205  81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIvGSPMLFVQQLEVKYDFLYEKRHVCC 156

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

28-159

4.81e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 41.32 E-value: 4.81e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsYVTTTVPQMLVNMVCPRrTISWGACVAQMFIF 107
Cdd:cd15928   1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRYR-PWRFGDLLCRLMYF 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 108 LLLGIAECVLYAIMAY--DRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGA 159
Cdd:cd15928  79 FSETCTYASILHITALsvERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSA 132

7tmA_XCR1

cd15182

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

33-235

6.16e-04

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.

Pssm-ID: 341337 [Multi-domain] Cd Length: 271 Bit Score: 40.81 E-value: 6.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  33 FFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYvTTTVPQMLVNmvcprRTISW----GACVAQMFIFl 108
Cdd:cd15182   6 FYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLF-TFTLPFWASY-----HSSGWifgeILCKAVTSIF- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 109 LLGIAECVLY-AIMAYDRYVAICFPLhySVLMSR-LVCIKMVTVC-WSISITGALIYTVFTMRLPycgpykinhffcevP 185
Cdd:cd15182  79 YIGFYSSILFlTLMTIDRYLAVVHPL--SALRSRkLRYASLVSVAvWVISILASLPELILSTVMK--------------S 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129411 186 AVLKLACADTSFNDRLDFILGF-IFLLVPLSLILASYACIFASILRIRSSQ 235
Cdd:cd15182 143 DEDGSLCEYSSIKWKLGYYYQQnLFFLIPLGIIVYCYVRILQTLMRTRTMR 193

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

32-156

6.98e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 40.59 E-value: 6.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRR-TISWGACVAQMFIFLLL 110
Cdd:cd15306   5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLF 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129411 111 GIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI 156
Cdd:cd15306  85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISI 130

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

28-155

8.11e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 40.33 E-value: 8.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVcpRRTISWGACVAQMFIF 107
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYEL--SGYWPFGEILCDVWIS 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 --LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15329  79 fdVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLS 128

7tmA_NMU-R1

cd15358

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...

32-174

1.08e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.

Pssm-ID: 320480 [Multi-domain] Cd Length: 305 Bit Score: 40.14 E-value: 1.08e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRR-TISWGACVAQMFIFLLL 110
Cdd:cd15358   5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPfLLGAGGCYFKTLLFETV 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129411 111 GIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAL----IYTVFTMRLPYCGP 174
Cdd:cd15358  85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIpntsLHGIFQLTVPCRGP 152

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

28-156

1.11e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 39.91 E-value: 1.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLllymiTLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTV-PQMLV---------NMVCprRTISW 97
Cdd:cd15196   6 VLATILVL-----ALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVlPQLIWdityrfyggDLLC--RLVKY 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129411  98 GAcVAQMFI--FLLLgiaecvlyaIMAYDRYVAICFPLHYSVLMSRLVCIkMVTVCWSISI 156
Cdd:cd15196  79 LQ-VVGMYAssYVLV---------ATAIDRYIAICHPLSSHRWTSRRVHL-MVAIAWVLSL 128

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

36-155

1.26e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 40.05 E-value: 1.26e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVD-MSYVTTTVPQ---------MLVNMVCprRTISWGACVAQmf 105
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADlVVAFFTVLTQiiweatgewVAGDVLC--RIVKYLQVVGL-- 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 106 iflllgIAECVLYAIMAYDRYVAICFPLhySVLMSRLVCIKMVTVCWSIS 155
Cdd:cd14986  85 ------FASTYILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLS 126

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

29-152

1.44e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 39.82 E-value: 1.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  29 ALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGAC-VAQMFIF 107
Cdd:cd15008   1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCkLVRYFQY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129411 108 LLLGIAECVLYAImAYDRYVAICFPLHYSVlmSRLVCIKMVTVCW 152
Cdd:cd15008  81 LTPGVQIYVLLSI-CVDRFYTIVYPLSFKV--SREKAKKMIAASW 122

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

32-155

1.96e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 39.26 E-value: 1.96e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACvaqmFIFLLLG 111
Cdd:cd15065   4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFC----NIWISFD 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 112 IAECV-----LYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15065  80 VMCSTasilnLCAI-SLDRYIHIKKPLKYERWMTTRRALVVIASVWILS 127

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

39-216

2.41e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 39.07 E-value: 2.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  39 MITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIAECVLY 118
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 119 AIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISI--TGALIYTVFTMRlpycgpyKINHFFCEVPAVLKLACADTS 196
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTvyTSVFLYTKAVEE-------GLAELLTSVPCVGSCQLLYNK 164

                       170       180
                ....*....|....*....|
gi 22129411 197 FNDRLDFILGFIFLLVPLSL 216
Cdd:cd15318 165 LWGWLNFPVFFIPCLIMIGL 184

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

35-155

2.41e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 39.15 E-value: 2.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLvnmvcprrTISWGACV----AQMFIFLLL 110
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAI--------TISLGFCTdfhsCLFLACFVL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129411 111 GIAECVLYAIMAY--DRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15069  80 VLTQSSIFSLLAVavDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLA 126

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

32-237

2.74e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 38.82 E-value: 2.74e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACvaQMFIFLLLG 111
Cdd:cd15096   5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWC--KIVQYLVYV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYA--IMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAlIYTVFTMRLPYCGPYKINHFFCEVPAVLK 189
Cdd:cd15096  83 TAYASVYTlvLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVAN-IPVLFLHGVVSYGFSSEAYSYCTFLTEVG 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 190 LACadtsfndRLDFILGFIF-LLVPLSLILASYACIFASILRIRSSQGR 237
Cdd:cd15096 162 TAA-------QTFFTSFFLFsYLIPLTLICVLYMLMLRRLRRQKSPGGR 203

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

32-171

2.79e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 38.64 E-value: 2.79e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGAC-VAQMFIFLLL 110
Cdd:cd15979   5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICkAVAYLMGVSV 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129411 111 GIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMRLPY 171
Cdd:cd15979  85 SVSTFSLVAI-AIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPV 144

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

32-234

3.10e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 38.80 E-value: 3.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVAICFPlHYSvlmsrlVCIKMVTVCwsISITGALIYTVFTMRLPYCG-------PYKINhffCEV 184
Cdd:cd15074  85 CCSINTLTAISIYRYLKICHP-PYG------PKLSRRHVC--IVIVAIWLYALFWAVAPLVGwgsygpePFGTS---CSI 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129411 185 PAVLKLAcadtSFNDRLDFILGFIF-LLVPLSLILASYACIFASILRIRSS 234
Cdd:cd15074 153 DWTGASA----SVGGMSYIISIFIFcYLLPVLIIVFSYVKIIRKVKSSRKR 199

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

36-159

3.80e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 38.33 E-value: 3.80e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsYVTTTVPQMLVNMvCPRRTISWGACVAQMFIFlllgIAEC 115
Cdd:cd15131   9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDL-LIFLCMPLDLYRL-WQYRPWNFGDLLCKLFQF----VSES 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 116 VLYAI------MAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGA 159
Cdd:cd15131  83 CTYSTilnitaLSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSA 132

7tmA_GPR153_GPR162-like

cd14998

orphan G protein-coupled receptors 153 and 162, member of the class A family of ...

39-155

3.93e-03

orphan G protein-coupled receptors 153 and 162, member of the class A family of seven-transmembrane G protein-coupled receptors; This group contains the G-protein coupled receptor 153 (GPR153), GPR162, and similar proteins. These are orphan GCPRs with unknown endogenous ligand and function. GPR153 and GPR163 are widely expressed in the central nervous system (CNS) and share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain an HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors which is important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in both GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320129 Cd Length: 301 Bit Score: 38.38 E-value: 3.93e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  39 MITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsyVTTTVPQMLVNMVCPRRTIS---WGACVAQMFI--FLLLGIA 113
Cdd:cd14998  12 GLSLLANAWGILSISAKQQKHKPLELLLCFLAGTHM--LMVAVPLTTYSVVQLRRQASdydWNEGLCKVFVstFYTLTLA 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129411 114 ECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd14998  90 TCFTVTSLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVS 131

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

40-160

4.24e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 38.47 E-value: 4.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  40 ITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPqMLVNMVCPRRTISWGACVAQMFIFllLGIAECVLYA 119
Cdd:cd15218  13 VSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFP-FVFTSVKNGSTWTYGTLTCKVIAF--LGVLSCFHTA 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129411 120 IMAY----DRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAL 160
Cdd:cd15218  90 FMLFcisvTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAF 134

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

36-155

4.36e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 38.35 E-value: 4.36e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  36 LLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGIAEC 115
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22129411 116 VLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15959  89 ETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAIS 128

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

28-252

5.38e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 38.01 E-value: 5.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIYTVFTMR-LPYCGPYKINHFFCEVPA 186
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTiAKENNSTTCFEFLSEWLA 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129411 187 VLKLAcadtsfndrLDFILGFIFLLvPLSLILASYACIFASILRIRSSQGRLKSFSTCASHITVVT 252
Cdd:cd14982 161 SAAPI---------VLIALVVGFLI-PLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVL 216

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

35-129

6.71e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 37.44 E-value: 6.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGA-CVAQMFIFLLLGIA 113
Cdd:cd15212   8 LAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDRlCLANGFFNACFGIV 87

                        90
                ....*....|....*.
gi 22129411 114 ECVLYAIMAYDRYVAI 129
Cdd:cd15212  88 STLTMTLISFDRYYAI 103

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-155

6.91e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.79 E-value: 6.91e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  31 FIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNmvcpRRTISWGA----CVAQMFI 106
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIW----RITVEWRAgdfaCKVIRYL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129411 107 FLLLGIAECVLYAIMAYDRYVAICFPLHYSvlMSRLVCIKMVTVCWSIS 155
Cdd:cd15197  80 QVVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILS 126

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

28-234

7.81e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 37.27 E-value: 7.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMsYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADE-LFLLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICFPL----HYSVLMSRLVCIKMvtvcWSISITGALIYTVFTMRLPYCGPykinhffcE 183
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVkslrFRTPRKAKLVSLCV----WALSLVLGLPVIIFARTLQEEGG--------T 147

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129411 184 VPAVLKLAcADTSFNDRL----DFILGFIfllVPLSLILASYACIfasILRIRSS 234
Cdd:cd14970 148 ISCNLQWP-DPPDYWGRVftiyTFVLGFA---VPLLVITVCYSLI---IRRLRSS 195

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-156

8.27e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 37.47 E-value: 8.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIF 107
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129411 108 LLLGIAECVLYAIMAYDRYVAICF-PLHYSvlMSRLVCIKMVTVCWSISI 156
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICCqPLVYK--MTPLRVAVMLGGCWVIPT 128

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

28-160

8.42e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 37.49 E-value: 8.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGAC-VAQMFI 106
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMChFSNFAQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 107 FLLLGIAECVLYAImAYDRYVAICFPLHYSVLMSRLVCIkmVTVCWSISITGAL 160
Cdd:cd15202  81 YCSVHVSAYTLTAI-AVDRYQAIMHPLKPRISKTKAKFI--IAVIWTLALAFAL 131

7tmA_Encephalopsin

cd15078

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...

35-235

8.51e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320206 [Multi-domain] Cd Length: 279 Bit Score: 37.12 E-value: 8.51e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  35 LLLYMITLLG---NGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLG 111
Cdd:cd15078   5 LLIATIGFLGvcnNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFG 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 112 IAECVLYAIMAYDRYVaicfplhysvlmsRLVCIKMVTVCWSI-SITGALIYTVFTMRLPYCGpykINHFFCEVPavlKL 190
Cdd:cd15078  85 IVSIMTLTVLAYERYI-------------RVVHAKVVNFSWSWrAITYIWLYSLAWTGAPLLG---WNRYTLEVH---GL 145

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129411 191 ACA---------DTSFndRLDFILGFIFllVPLSLILASYACIFASILRIRSSQ 235
Cdd:cd15078 146 GCSfdwkskdpnDTSF--VLLFFLGCLV--VPLGIMAYCYGHILYEIRMLRSVE 195

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

29-160

8.73e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 37.06 E-value: 8.73e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  29 ALFIFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFL 108
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMG 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129411 109 LLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAL 160
Cdd:cd15209  82 LSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVL 133

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

33-228

9.29e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 37.00 E-value: 9.29e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  33 FFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVAQMFIFLLLGI 112
Cdd:cd15336   6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 113 AECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGALIytvftmrlPYCGpykinhFFCEVPAVLKLAC 192
Cdd:cd15336  86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLP--------PLFG------WSAYVPEGLLTSC 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22129411 193 A-----DTSFNDRLDFILGFIFLLVPLSLILASYACIFASI 228
Cdd:cd15336 152 TwdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAI 192

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

99-301

9.30e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 37.08 E-value: 9.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  99 ACVAQMFIFLLLGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVcWSISitgaliytvftmrlpycgpykin 178
Cdd:cd15082  85 ACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WTFS----------------------- 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 179 hFFCEVPAVLKLACADTS--------------FNDRlDFILGFIF--LLVPLSLILASYACIFASILRIRSSQGRLKSFS 242
Cdd:cd15082 141 -FIWTIPPVLGWSSYTVSkigttcepnwysgnMHDH-TYIITFFTtcFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNAR 218

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129411 243 TCASHIT--VVTMFYGpAMIMYM-----------RPGSWYDPeRDKKLALFYNVVSAFLNPIIYSLRNKDVK 301
Cdd:cd15082 219 KPERQVTrmVVVMIVA-FMVCWTpyaafsilvtaHPTIHLDP-RLAAIPAFFSKTAAVYNPIIYVFMNKQFR 288

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

32-155

9.79e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 37.19 E-value: 9.79e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  32 IFFLLLYMITLLGNGLIITLIYLDSRLHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVcpRRTISWGACVAQMF--IFLL 109
Cdd:cd15958   5 LLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVV--RGRWLYGSFFCELWtsVDVL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129411 110 LGIAECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSIS 155
Cdd:cd15958  83 CVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAIS 128

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-182

9.89e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 37.13 E-value: 9.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411  28 VALFIFFLLLYMITLLGNGliITLIYLDSR-----LHTPMYFFLSILSLVDMSYVTTTVPQMLVNMVCPRRTISWGACVA 102
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNS--ITLYTLARKkslqhLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAAC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129411 103 QMFIFLLLGI--AECVLYAIMAYDRYVAICFPLHYSVLMSRLVCIKMVTVCWSISITGAlIYTVFTMRLPYCGPYKINHF 180
Cdd:cd15355  79 RGYYFLRDACtyATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLA-IPMLFTMGEQNRSGTHPGGL 157


                ..
gi 22129411 181 FC 182
Cdd:cd15355 158 IC 159

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01