FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262263347 630 KPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEkcfRVSHTLAGDGVPAAPGLP 701
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRH---LRTHHNNPSDLNSKSLPL 100

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347 572 GEKPFRCE--NCNERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKR 649
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                 ....*.
gi 262263347 650 HrRTHT 655
Cdd:COG5189  417 H-RKHS 421

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347    4 LNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALAPGGLQQILNFIYTSKlLVN 82
Cdd:pfam00651   1 LNELRE-QGELCDV--TLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVsEITLDDVSPEDFEALLEFMYTGK-LIS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 262263347   83 AANVHEVLSAASLLQMADIAASCQELLDARS 113
Cdd:pfam00651  77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262263347 630 KPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEkcfRVSHTLAGDGVPAAPGLP 701
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRH---LRTHHNNPSDLNSKSLPL 100

PRLI-interacting factor K; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262263347 422 DGLGAKVKLEE-KQHHPCQKCPRVFNNRwYLEKHMNVTHSRMqicdQCGKRFLLESELLL-HRQTDCE-RNIQCVTCG 496
Cdd:PLN03086 439 DGCGIVLRVEEaKNHVHCEKCGQAFQQG-EMEKHMKVFHEPL----QCPCGVVLEKEQMVqHQASTCPlRLITCRFCG 511

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347 431 EEKQHHPCQKCPRVFNNRWYLEKHMNVTHSRMQICDQCGKRFLLES-----ELLLHRQTDCERNIQCVTCGKAFKKLWSL 505
Cdd:COG5048  226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQssspnESDSSSEKGFSLPIKSKQCNISFSRSSPL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347 506 HEHNKIVH--GYAEKKFSC--EICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS-------------MSLKVHSL 568
Cdd:COG5048  306 TRHLRSVNhsGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppqslqqYKDLKNDK 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347 569 QHSGEKPFRCENCNERFQYKYQLRSHMSIhiGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFtSRPNMK 648
Cdd:COG5048  386 KSETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR-RDLDLS 462

                 ..
gi 262263347 649 RH 650
Cdd:COG5048  463 NH 464

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 262263347   632 YICEICGKSFTSRPNMKRHRRTH 654
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347    4 LNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALAPGGLQQILNFIYTSKlLVN 82
Cdd:pfam00651   1 LNELRE-QGELCDV--TLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVsEITLDDVSPEDFEALLEFMYTGK-LIS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 262263347   83 AANVHEVLSAASLLQMADIAASCQELLDARS 113
Cdd:pfam00651  77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   1 MGRLNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQL-QRVELSLEALAPGGLQQILNFIYTSKL 79
Cdd:cd18326   13 LSSLNEQRT-QGLLCDV--VILVEGREFPTHRSVLAACSQYFKKLFTSGAVVdQQNVYEIDFVSAEALTALLDFAYTATL 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 262263347  80 LVNAANVHEVLSAASLLQMADIAASCQELLD 110
Cdd:cd18326   90 TVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   1 MGRLNEQRLFQPdLCDVDLVLvpQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEAlapgGLQQILNFIYTSKLL 80
Cdd:cd18206   10 LEQLNQQRQLGL-LCDCTFVV--DGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAA----GLGQVLEFMYTAKLS 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQELLD 110
Cdd:cd18206   83 LSPENVDDVLAVATFLQMQDIVTACHALKS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   1 MGRLNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVE--------LSLEALAPGGLQQILN 72
Cdd:cd18228    7 LGKLNSLRN-EGHFCDV--TIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspagkcvLDLHHVTVTGFAPLLE 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 262263347  73 FIYTSKLLVNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18228   84 YAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347    18 DLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPGGLQQILNFIYTSKLLVNAANVHEVLSAASLL 96
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 262263347    97 QMADIAASCQELLDARS 113
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLfQPDLCDVDlVLVPQRsVFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPGGLQQILNFIYTSKLL 80
Cdd:cd18329   11 QLDEQRK-QELFCDCS-ILVEGQ-VFKAHRNVLFASSGYFKMLLSQNAKetGQPTVATFDVFSPDTFTIILDFVYSGKLS 87

                         90       100
                 ....*....|....*....|....*.
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQ 106
Cdd:cd18329   88 LTSQNVIEVMSAASYLQMTDVISVCK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347  14 LCDVdlVLVPQRSV--FPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALAPGGLQQILNFIYTSKLLVNAANVHEVL 90
Cdd:cd18239   23 LCDV--TLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQELmCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTL 100

                         90
                 ....*....|....*....
gi 262263347  91 SAASLLQMADIAASCQELL 109
Cdd:cd18239  101 EAASFLQILPVLDFCKVLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   1 MGRLNEQRLfQPDLCDVDlVLVPQRsVFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPGGLQQILNFIYTSK 78
Cdd:cd18199    6 LGQLNEQRK-QDFFCDCS-IIVEGR-IFKAHRNVLFASSGYFRMLLSHYIQdtGRPSTASFDVFSSDAFSIILDFVYSGK 82

                         90       100
                 ....*....|....*....|....*...
gi 262263347  79 LLVNAANVHEVLSAASLLQMADIAASCQ 106
Cdd:cd18199   83 LSLTSQNVIEVMSAASYLQMTDVINVCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLFQPDLCD-------VDLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALAPGGLQQILNFI 74
Cdd:cd18340    7 RLYQQTLLQDGLKDlldhnkfVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKrEIVLEDVDPDVMGKILHYI 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 262263347  75 YTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDAR 112
Cdd:cd18340   87 YTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKR 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFtQNKQLQRVEL-SLEALAPGGLQQILNFIYTSKLLV 81
Cdd:cd18233    8 QLHEQRI-QGLLCDC--MLVVKGVCFKAHKNVLAAFSQYFRSLF-QNSSSQKNDVfHLDIKNVGGIGQILDFMYTSHLDL 83

                         90       100
                 ....*....|....*....|....*...
gi 262263347  82 NAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18233   84 NQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   4 LNEQRLFQpDLCDVDLVL--VPQRSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALAPGGLQQILNFIYTSKLL 80
Cdd:cd18248   12 MNELRLSQ-QLCDVTLKVkyQDPKEEFMAHKVVLASSSPYFKAMFTSGlRECGMEVVPIEGVHPCVMSRLIEFAYTASIS 90

                         90       100
                 ....*....|....*....|....*....
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18248   91 VGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   4 LNEQRlFQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALAPGGLQQILNFIYTSKLLVN 82
Cdd:cd18328   16 LNEQR-HDGLLCDV--VLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVyEIDFVTPEALSAILEFAYTSTLTIT 92

                         90       100
                 ....*....|....*....|....*...
gi 262263347  83 AANVHEVLSAASLLQMADIAASCQELLD 110
Cdd:cd18328   93 TSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347  14 LCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALAPGGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18264   28 LCDV--VLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARvIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEA 105

                         90       100
                 ....*....|....*....|....
gi 262263347  93 ASLLQMADIAASCQELLdARSLGP 116
Cdd:cd18264  106 ASYLQVTEAIGLCSQYL-INNLAP 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLfQPDLCDVdlVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQrveLSLEALAPGGLQQILNFIYTSKLLVN 82
Cdd:cd18216   10 QLNNQRT-KGFLCDV--IIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIH---LDQDMVSPTVFQQILDFIYTGKLLDS 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 262263347  83 A---ANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18216   84 LfeePNLSEVLAAANYLQLPDLAALCRSKL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLFQPDLCDVdLVLVPQRSvFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALAPGGLQQILNFIYTSKLL 80
Cdd:cd18207   16 NLNQQRKSGGRFCDV-LLRVGEES-FPAHRAVLAACSEYFESVFSAQEGdgGTPRELEMHTISSKVFGDILDFAYTSRIV 93

                         90       100
                 ....*....|....*....|....*....
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18207   94 VRLESFPELMTAAKFLLMRSVIDICQEVI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347  14 LCDVDLVlVPQRSvFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALAPGGLQQILNFIYTSKLLVNAANVHEVLSA 92
Cdd:cd18238   15 LCDVTLK-VGEKS-IHCHRLVLACVSPYFRAMFTSEMAESKQDSiTIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYA 92

                         90
                 ....*....|....*..
gi 262263347  93 ASLLQMADIAASCQELL 109
Cdd:cd18238   93 ASLLQVEEVAKACCEFM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   1 MGRLNEQRLfqpdLCDvdLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSleALAPGGLQQILNFIYTSKLL 80
Cdd:cd18260    9 LNRMRQERF----LCD--LTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELN--DISPLGLATVITYAYTGKLT 80

                         90       100
                 ....*....|....*....|....*....
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18260   81 LSLYTIGSTISAASYLQIHALVKMCCDFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   3 RLNEQRLFQPDLCD-------VDLVLVPQRSVFPAHKGVLAAYSQFFHSLF-TQNKQLQRVELSLEALAPGGLQQILNFI 74
Cdd:cd18269    7 RLYQQTLLQDGLKDlldenkfVDCVLKIGDKEFPCHRLVLAACSPYFRAMFlSDLEESKKKEVVLEDVDPDVMGMILKYL 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 262263347  75 YTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDAR 112
Cdd:cd18269   87 YTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKR 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   4 LNEQRLFqpdlcdVDLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSL-EALAPGGLQQILNFIYTSKLLV 81
Cdd:cd18267   34 LRQQRLF------TDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGlKESQDSEVNFhDSIHPEVLELLLDYAYSSRVII 107

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 262263347  82 NAANVHEVLSAASLLQMADIAASCQELLDaRSLGP 116
Cdd:cd18267  108 NEENAESLLEAGDMLEFQDIRDACAEFLE-KNLHP 141

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   4 LNEQRlfqPD--LCDVDLVLVPQRsvFPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALAPGGLQQILNFIYTSKLL 80
Cdd:cd18261   19 LNQQR---NDgiLCDITLVAEEQK--FHAHKAVLAACSDYFRAMFSLCMvESEADEVNLHGVTSLGLKQALDFAYTGQIL 93

                         90       100
                 ....*....|....*....|....*....
gi 262263347  81 VNAANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18261   94 LEPGVIQDVLAAGSHLQLLELLSLCSHYL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263347   4 LNEQRLfQPDLCDVDLVLvpQRSVFPAHKGVLAAYSQFF-HSLFTQNKQLQRVELSLEALAPGgLQQILNFIYTSKLLVN 82
Cdd:cd18278   22 LNDQRK-QDILCDVTLIV--EGKEFRAHRAVLAACSEYFlQALVGQTENDLVVSLPEEVTARG-FGPLLQFAYTAKLLLS 97

                         90       100
                 ....*....|....*....|....*..
gi 262263347  83 AANVHEVLSAASLLQMADIAASCQELL 109
Cdd:cd18278   98 RENIQEVIRCAEFLRMHNLEDSCFRFL 124