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Conserved domains on  [gi|21450659|ref|NP_659405|]
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RIB43A-like with coiled-coils protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIB43A super family cl25743
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
 9-181 2.76e-64

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


The actual alignment was detected with superfamily member pfam05914:

Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 202.43  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659     9 DTKEAAAIEARRNREKERQNRFFNVRNRVMGVDVQALNNQVGDRKRREAAERSKEAAYGTSQVQYDVVVQMLEKEEADRT 88
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659    89 RQLAKKVQEFREQKQQLKNGREFSLWDPGQVWKGLPTYLSYSNTYPGPASLQYFSGEDLDRDTRLRMQQGQFRYNLERQQ 168
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161

                         170
                  ....*....|...
gi 21450659   169 QEQQQAKVDENYT 181
Cdd:pfam05914 162 EEKKQAEEEEKHA 174
 
Name Accession Description Interval E-value
RIB43A pfam05914
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
 9-181 2.76e-64

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 202.43  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659     9 DTKEAAAIEARRNREKERQNRFFNVRNRVMGVDVQALNNQVGDRKRREAAERSKEAAYGTSQVQYDVVVQMLEKEEADRT 88
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659    89 RQLAKKVQEFREQKQQLKNGREFSLWDPGQVWKGLPTYLSYSNTYPGPASLQYFSGEDLDRDTRLRMQQGQFRYNLERQQ 168
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161

                         170
                  ....*....|...
gi 21450659   169 QEQQQAKVDENYT 181
Cdd:pfam05914 162 EEKKQAEEEEKHA 174
 
Name Accession Description Interval E-value
RIB43A pfam05914
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
 9-181 2.76e-64

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 202.43  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659     9 DTKEAAAIEARRNREKERQNRFFNVRNRVMGVDVQALNNQVGDRKRREAAERSKEAAYGTSQVQYDVVVQMLEKEEADRT 88
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450659    89 RQLAKKVQEFREQKQQLKNGREFSLWDPGQVWKGLPTYLSYSNTYPGPASLQYFSGEDLDRDTRLRMQQGQFRYNLERQQ 168
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161

                         170
                  ....*....|...
gi 21450659   169 QEQQQAKVDENYT 181
Cdd:pfam05914 162 EEKKQAEEEEKHA 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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