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Conserved domains on  [gi|24308440|ref|NP_612410|]
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multivesicular body subunit 12A isoform 1 [Homo sapiens]

Protein Classification

MVB12 family protein( domain architecture ID 10562994)

MVB12 family protein similar to Homo sapiens Multivesicular body subunits, 12A and 12B, components of the ESCRT-I complex that is a regulator of vesicular trafficking process

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF2464 pfam10240
Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ...
10-261 5.07e-89

Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.


:

Pssm-ID: 431164  Cd Length: 255  Bit Score: 264.56  E-value: 5.07e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    10 APLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKS--FAQKSGYFLCLSSLgslENPQENVVADIQIVVDKSPLPLGFS 87
Cdd:pfam10240   1 RPITAVCIVADLNKCPPGFTVISRTYDGSDADLWKDglFGSKSGRYLCFSKT---EGLPGYVVVDIKVIGEKDPIPHGYS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    88 PVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVP-GYLRIGDMGGFAIWCKKAK--APRPVPKPRGLSR 164
Cdd:pfam10240  78 YIPETADSKEKAWRKKRLCVKLSPRGSTETAVTDIILCSKSKKAPqGYTLAGEINGILICYKMGAisQPPPQPKPRSVSL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440   165 DMQGLSLDAASQPSKGGLLERTAS--RLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPlAFSAFGDL 242
Cdd:pfam10240 158 PLPSLSLELSPSRPAPPPPLSSSSlpSRRSTLRPSDNNDSTTDTSTLYGISALDGVPFILNPKFESSPSST-QSSQLPDI 236
                         250
                  ....*....|....*....
gi 24308440   243 TIKSLADIEEEYNYGFVVE 261
Cdd:pfam10240 237 PIKSLADIEKEYNYDFAVE 255
 
Name Accession Description Interval E-value
DUF2464 pfam10240
Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ...
10-261 5.07e-89

Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.


Pssm-ID: 431164  Cd Length: 255  Bit Score: 264.56  E-value: 5.07e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    10 APLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKS--FAQKSGYFLCLSSLgslENPQENVVADIQIVVDKSPLPLGFS 87
Cdd:pfam10240   1 RPITAVCIVADLNKCPPGFTVISRTYDGSDADLWKDglFGSKSGRYLCFSKT---EGLPGYVVVDIKVIGEKDPIPHGYS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    88 PVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVP-GYLRIGDMGGFAIWCKKAK--APRPVPKPRGLSR 164
Cdd:pfam10240  78 YIPETADSKEKAWRKKRLCVKLSPRGSTETAVTDIILCSKSKKAPqGYTLAGEINGILICYKMGAisQPPPQPKPRSVSL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440   165 DMQGLSLDAASQPSKGGLLERTAS--RLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPlAFSAFGDL 242
Cdd:pfam10240 158 PLPSLSLELSPSRPAPPPPLSSSSlpSRRSTLRPSDNNDSTTDTSTLYGISALDGVPFILNPKFESSPSST-QSSQLPDI 236
                         250
                  ....*....|....*....
gi 24308440   243 TIKSLADIEEEYNYGFVVE 261
Cdd:pfam10240 237 PIKSLADIEKEYNYDFAVE 255
 
Name Accession Description Interval E-value
DUF2464 pfam10240
Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ...
10-261 5.07e-89

Multivesicular body subunit 12; MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.


Pssm-ID: 431164  Cd Length: 255  Bit Score: 264.56  E-value: 5.07e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    10 APLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKS--FAQKSGYFLCLSSLgslENPQENVVADIQIVVDKSPLPLGFS 87
Cdd:pfam10240   1 RPITAVCIVADLNKCPPGFTVISRTYDGSDADLWKDglFGSKSGRYLCFSKT---EGLPGYVVVDIKVIGEKDPIPHGYS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440    88 PVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVP-GYLRIGDMGGFAIWCKKAK--APRPVPKPRGLSR 164
Cdd:pfam10240  78 YIPETADSKEKAWRKKRLCVKLSPRGSTETAVTDIILCSKSKKAPqGYTLAGEINGILICYKMGAisQPPPQPKPRSVSL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308440   165 DMQGLSLDAASQPSKGGLLERTAS--RLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPlAFSAFGDL 242
Cdd:pfam10240 158 PLPSLSLELSPSRPAPPPPLSSSSlpSRRSTLRPSDNNDSTTDTSTLYGISALDGVPFILNPKFESSPSST-QSSQLPDI 236
                         250
                  ....*....|....*....
gi 24308440   243 TIKSLADIEEEYNYGFVVE 261
Cdd:pfam10240 237 PIKSLADIEKEYNYDFAVE 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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