NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|124301201|ref|NP_598682|]

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NF-X1-type zinc finger protein NFXL1 isoform 1 [Mus musculus]

Protein Classification

RING-CH-C4HC3_NFXL1 and NF-X1-zinc-finger domain-containing protein( domain architecture ID 11616384)

RING-CH-C4HC3_NFXL1 and NF-X1-zinc-finger domain-containing protein

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

RING-CH-C4HC3_NFXL1

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box ...

165-227

1.52e-26

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins; NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers.

:

Pssm-ID: 438358 Cd Length: 63 Bit Score: 103.19 E-value: 1.52e-26

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124301201 165 MTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDYPWPCPKCR 227
Cdd:cd16697    1 STCLICIESIKRNDAIWSCSGCFCIFHLPCIQKWAKDSIFLVSLRSASDFPQKELPWHCPKCR 63

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

421-469

3.32e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 58.90 E-value: 3.32e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 421 CGDSCDKILECGIHRCSQRCHRGPCETCRQEVEKQCRCGKHTKRMPCHK 469
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

368-416

7.93e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 57.74 E-value: 7.93e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 368 CDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRSCPCQKSKFSLPCTE 416
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

315-363

4.65e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 55.81 E-value: 4.65e-10

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 315 CQLPCGRKLLCGHHKCENPCHAGNCQPCPRVSRQKCVCGKKVAERSCAS 363
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

500-548

1.08e-09

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 54.66 E-value: 1.08e-09

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 500 CDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNAKVTVPCGR 548
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

772-818

1.50e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.50e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 772 CKNQCPKELPCG-HRCKEMCHPGECPfNCNQKVKLRCPCKRIKRELPC 818
Cdd:cd06008    1 CGEVCGKPLPCGnHKCEQLCHEGPCP-PCPETVKKKCRCGKTTKEVPC 47

NF-X1-zinc-finger super family

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

708-755

7.36e-04

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

The actual alignment was detected with superfamily member cd06008:

Pssm-ID: 100116 Cd Length: 49 Bit Score: 38.10 E-value: 7.36e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 708 CEEGCSKSRPAGcPHPCVLPCHPGKCPPCVQMLRIKCHCKITSLYVEC 755
Cdd:cd06008    1 CGEVCGKPLPCG-NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPC 47

Name

Accession

Description

Interval

E-value

RING-CH-C4HC3_NFXL1

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box ...

165-227

1.52e-26

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins; NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers.

Pssm-ID: 438358 Cd Length: 63 Bit Score: 103.19 E-value: 1.52e-26

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124301201 165 MTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDYPWPCPKCR 227
Cdd:cd16697    1 STCLICIESIKRNDAIWSCSGCFCIFHLPCIQKWAKDSIFLVSLRSASDFPQKELPWHCPKCR 63

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

421-469

3.32e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 58.90 E-value: 3.32e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 421 CGDSCDKILECGIHRCSQRCHRGPCETCRQEVEKQCRCGKHTKRMPCHK 469
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

368-416

7.93e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 57.74 E-value: 7.93e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 368 CDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRSCPCQKSKFSLPCTE 416
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

315-363

4.65e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 55.81 E-value: 4.65e-10

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 315 CQLPCGRKLLCGHHKCENPCHAGNCQPCPRVSRQKCVCGKKVAERSCAS 363
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

500-548

1.08e-09

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 54.66 E-value: 1.08e-09

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 500 CDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNAKVTVPCGR 548
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

772-818

1.50e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.50e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 772 CKNQCPKELPCG-HRCKEMCHPGECPfNCNQKVKLRCPCKRIKRELPC 818
Cdd:cd06008    1 CGEVCGKPLPCGnHKCEQLCHEGPCP-PCPETVKKKCRCGKTTKEVPC 47

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

708-755

7.36e-04

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 38.10 E-value: 7.36e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 708 CEEGCSKSRPAGcPHPCVLPCHPGKCPPCVQMLRIKCHCKITSLYVEC 755
Cdd:cd06008    1 CGEVCGKPLPCG-NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPC 47

Name

Accession

Description

Interval

E-value

RING-CH-C4HC3_NFXL1

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box ...

165-227

1.52e-26

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins; NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers.

Pssm-ID: 438358 Cd Length: 63 Bit Score: 103.19 E-value: 1.52e-26

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124301201 165 MTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDYPWPCPKCR 227
Cdd:cd16697    1 STCLICIESIKRNDAIWSCSGCFCIFHLPCIQKWAKDSIFLVSLRSASDFPQKELPWHCPKCR 63

RING-CH-C4HC3_NFX1-like

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type ...

165-227

3.00e-15

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFXL1, also known as NF-X1-type zinc finger protein NFXL1 or ovarian zinc finger protein (OZFP), is encoded by a novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. This subfamily also includes NF-X1 homologs from insects, plants, and fungi. Drosophila melanogaster shuttle craft (STC) is a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system. It functions as a putative transcription factor and plays an essential role in the completion of embryonic development. In contrast to NF-X1, STC contains an RD domain. The Arabidopsis genome encodes two NF-X1 homologs, AtNFXL1 and AtNFXL2, both of which function as regulators of salt stress responses. The AtNFXL1 protein is a nuclear factor that positively affects adaptation to salt stress. It also functions as a negative regulator of the type A trichothecene phytotoxin-induced defense response. AtNFXL2 controls abscisic acid (ABA) levels and suppresses ABA responses. It may also prevent unnecessary and costly stress adaptation under favorable conditions. FKBP12-associated protein 1 (FAP1) is a dosage suppressor of rapamycin toxicity in budding yeast. It is localized in the cytoplasm, but upon rapamycin treatment translocates to the nucleus. FAP1 interacts with FKBP12 in a rapamycin-sensitive manner. It is a proline-rich protein containing a novel cysteine-rich DNA-binding motif. Unique structural features of the NFX1 and NFXL proteins are the Cys-rich region and a specific RING-CH finger motif with an unusual arrangement of zinc-coordinating residues. The Cys-rich region is required for binding to specific promoter elements. It frequently comprises more than 500 amino acids and harbors several NFX1-type zinc finger domains, characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The RING-CH finger, also known as vRING or RINGv, may have E3 ligase activity. It is characterized by a C4HC3-type Zn ligand signature and additional conserved amino acids, rather than the C3H2C3-type cysteines and histidines arrangement in canonical RING-H2 finger. In addition to the Cys-rich region and RING-CH finger, NFX1 contains a PAM2 motif in the N-terminus and a R3H domain in the C-terminus.

Pssm-ID: 438155 [Multi-domain] Cd Length: 58 Bit Score: 70.55 E-value: 3.00e-15

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124301201 165 MTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSVtdddfGKKDYPWPCPKCR 227
Cdd:cd16492    1 YECMICTENVGRNQSIWSCSRCYRVFHLSCIKKWAKNSEEKAEQV-----KNDDDSWRCPGCQ 58

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

421-469

3.32e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 58.90 E-value: 3.32e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 421 CGDSCDKILECGIHRCSQRCHRGPCETCRQEVEKQCRCGKHTKRMPCHK 469
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

368-416

7.93e-11

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 57.74 E-value: 7.93e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 368 CDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRSCPCQKSKFSLPCTE 416
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

315-363

4.65e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 55.81 E-value: 4.65e-10

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 315 CQLPCGRKLLCGHHKCENPCHAGNCQPCPRVSRQKCVCGKKVAERSCAS 363
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

500-548

1.08e-09

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 54.66 E-value: 1.08e-09

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124301201 500 CDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNAKVTVPCGR 548
Cdd:cd06008    1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49

RING-CH-C4HC3_NFX1

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ...

167-226

9.06e-08

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain.

Pssm-ID: 438357 [Multi-domain] Cd Length: 55 Bit Score: 49.35 E-value: 9.06e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124301201 167 CLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQflvSSVTDDDFGkkdypWPCPKC 226
Cdd:cd16696    3 CMVCCEVVRVMAPVWSCSSCYHVFHLNCIKKWARSPA---AQAEDNSGG-----WRCPAC 54

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

772-818

1.50e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.50e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 772 CKNQCPKELPCG-HRCKEMCHPGECPfNCNQKVKLRCPCKRIKRELPC 818
Cdd:cd06008    1 CGEVCGKPLPCGnHKCEQLCHEGPCP-PCPETVKKKCRCGKTTKEVPC 47

NF-X1-zinc-finger

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...

708-755

7.36e-04

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.

Pssm-ID: 100116 Cd Length: 49 Bit Score: 38.10 E-value: 7.36e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 124301201 708 CEEGCSKSRPAGcPHPCVLPCHPGKCPPCVQMLRIKCHCKITSLYVEC 755
Cdd:cd06008    1 CGEVCGKPLPCG-NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPC 47

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

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