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Conserved domains on  [gi|18152769|ref|NP_542776.1|]
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ectodysplasin-A receptor-associated adapter protein isoform B [Homo sapiens]

Protein Classification

Death domain-containing protein (domain architecture ID 10455265)

Death domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Death pfam00531
Death domain;
119-189 1.21e-14

Death domain;


:

Pssm-ID: 306916  Cd Length: 86  Bit Score: 67.01  E-value: 1.21e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18152769   119 LDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQ---SPTLEFLLRNSQR-----TVGQLMELCRLYHRADVEKVLRRWV 189
Cdd:pfam00531   8 LDPPPPLGKDWRELARKLGLSENEIDEIEQQNPrlrSQTYELLRLWEQRegknaTVGTLLEALRKLGRRDAAEKIESIL 86
 
Name Accession Description Interval E-value
Death pfam00531
Death domain;
119-189 1.21e-14

Death domain;


Pssm-ID: 306916  Cd Length: 86  Bit Score: 67.01  E-value: 1.21e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18152769   119 LDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQ---SPTLEFLLRNSQR-----TVGQLMELCRLYHRADVEKVLRRWV 189
Cdd:pfam00531   8 LDPPPPLGKDWRELARKLGLSENEIDEIEQQNPrlrSQTYELLRLWEQRegknaTVGTLLEALRKLGRRDAAEKIESIL 86
Death_MyD88 cd08312
Death domain of Myeloid Differentation primary response protein MyD88; Death Domain (DD) of ...
119-181 1.03e-03

Death domain of Myeloid Differentation primary response protein MyD88; Death Domain (DD) of Myeloid Differentiation primary response protein 88 (MyD88). MyD88 is an adaptor protein involved in interleukin-1 receptor (IL-1R)- and Toll-like receptor (TLR)-induced activation of nuclear factor-kappaB (NF-kB) and mitogen activated protein kinase pathways that lead to the induction of proinflammatory cytokines. It is a key component in the signaling pathway of pathogen recognition in the innate immune system. MyD88 contains an N-terminal DD and a C-terminal Toll/IL-1 Receptor (TIR) homology domain that mediates interaction with TLRs and IL-1R. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260026  Cd Length: 79  Bit Score: 36.81  E-value: 1.03e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18152769 119 LDPCHPTVKNWRNFASKWGMSYDELCFLEQRPqSPTLEFL----LRNSQRTVGQLMELCRLYHRADV 181
Cdd:cd08312   9 LNPEKVVANDWRGLAELMGFDYLEIRNFERQS-SPTERLLedweTRPPGATVGNLLEILEELERKDV 74
 
Name Accession Description Interval E-value
Death pfam00531
Death domain;
119-189 1.21e-14

Death domain;


Pssm-ID: 306916  Cd Length: 86  Bit Score: 67.01  E-value: 1.21e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18152769   119 LDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQ---SPTLEFLLRNSQR-----TVGQLMELCRLYHRADVEKVLRRWV 189
Cdd:pfam00531   8 LDPPPPLGKDWRELARKLGLSENEIDEIEQQNPrlrSQTYELLRLWEQRegknaTVGTLLEALRKLGRRDAAEKIESIL 86
Death_MyD88 cd08312
Death domain of Myeloid Differentation primary response protein MyD88; Death Domain (DD) of ...
119-181 1.03e-03

Death domain of Myeloid Differentation primary response protein MyD88; Death Domain (DD) of Myeloid Differentiation primary response protein 88 (MyD88). MyD88 is an adaptor protein involved in interleukin-1 receptor (IL-1R)- and Toll-like receptor (TLR)-induced activation of nuclear factor-kappaB (NF-kB) and mitogen activated protein kinase pathways that lead to the induction of proinflammatory cytokines. It is a key component in the signaling pathway of pathogen recognition in the innate immune system. MyD88 contains an N-terminal DD and a C-terminal Toll/IL-1 Receptor (TIR) homology domain that mediates interaction with TLRs and IL-1R. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.


Pssm-ID: 260026  Cd Length: 79  Bit Score: 36.81  E-value: 1.03e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18152769 119 LDPCHPTVKNWRNFASKWGMSYDELCFLEQRPqSPTLEFL----LRNSQRTVGQLMELCRLYHRADV 181
Cdd:cd08312   9 LNPEKVVANDWRGLAELMGFDYLEIRNFERQS-SPTERLLedweTRPPGATVGNLLEILEELERKDV 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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