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Conserved domains on  [gi|1796340114|ref|NP_114091|]
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Bardet-Biedl syndrome 2 protein [Homo sapiens]

Protein Classification

BBS2_N and BBS2_C domain-containing protein( domain architecture ID 11236587)

protein containing domains BBS2_N, BBS2_Mid, and BBS2_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 276 TGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 356 EENAKAelasplNEADGHRGIIPANTRLHTTLSVSLGNEtqtaHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVNLETG----HVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 436 NLSSSICIPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLG 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 516 QNFLLPEDTHIQNAP-FQVCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEDESnLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 595 KVLVKVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1796340114 675 VNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFKIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 3.69e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 464314  Cd Length: 107  Bit Score: 200.17  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114  20 AIGRYDGTHPCLAAATQTGKVFIHNPHTRNQHVSASRVFQSPLESDVSLLSINQAVSCLTAGVLNPELGYDALLVGTQTN 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 1796340114 100 LLAYDVYNNSDLFYREVADGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 7.31e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


:

Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 196.72  E-value: 7.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 165 SLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 1796340114 245 MSIHAFDLNSDGVNELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
 
Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 276 TGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 356 EENAKAelasplNEADGHRGIIPANTRLHTTLSVSLGNEtqtaHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVNLETG----HVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 436 NLSSSICIPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLG 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 516 QNFLLPEDTHIQNAP-FQVCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEDESnLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 595 KVLVKVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1796340114 675 VNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFKIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 3.69e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 200.17  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114  20 AIGRYDGTHPCLAAATQTGKVFIHNPHTRNQHVSASRVFQSPLESDVSLLSINQAVSCLTAGVLNPELGYDALLVGTQTN 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 1796340114 100 LLAYDVYNNSDLFYREVADGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 7.31e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 196.72  E-value: 7.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 165 SLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 1796340114 245 MSIHAFDLNSDGVNELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
POLO_box_1 cd13118
First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser ...
 213-233 4.48e-03

First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240561  Cd Length: 91  Bit Score: 36.92  E-value: 4.48e-03
                          10        20
                  ....*....|....*....|...
gi 1796340114 213 YGsrFGYALSNGTVGVY--DKTS 233
Cdd:cd13118    15 YG--LGYQLSDGSVGVLfnDSTK 35
 
Name Accession Description Interval E-value
BBS2_C pfam14782
Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with ...
 276-715 0e+00

Ciliary BBSome complex subunit 2, C-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464315  Cd Length: 430  Bit Score: 727.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 276 TGEVIFKDNFSSAIAGVVEGDYRMDGHIQLICCSVDGEIRGYLPGTAEMRGNLMDTSAEQDLIRELSQKKQNLLLELRNY 355
Cdd:pfam14782   1 TGEVIFKDNLSSPIAGLVVADYRMDGKNQLICCSVDGEVRGYLPTGQEMKGALVDTSVEQELIRELLQKKQNLLLELKNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 356 EENAKAelasplNEADGHRGIIPANTRLHTTLSVSLGNEtqtaHTELRISTSNDTIIRAVLIFAEGIFTGESHVVHPsIH 435
Cdd:pfam14782  81 EENLKR------KKSGETDGTIPANTKLQTSLSVNLETG----HVELVVSTNNDTIIRAVIIFAEGIFEGESHVVHP-NQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 436 NLSSSICIPIVPPKDVPVDLHLKAFVGYRSSTQFHVFESTRQLPRFSMYALTSLDPASEPISYVNFTIAERAQRVVVWLG 515
Cdd:pfam14782 150 NPSSTLRIPLRPPKDVPVDLHIKVFVGSPGSSQFHVFELTRQLPKFSMYLLVKNPEPPEPSSYVTFRINERVQRVVLWLN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 516 QNFLLPEDTHIQNAP-FQVCFTSLRNGGHLHIKIKLSGEITINTDDIDLAGDIIQSMASFFAIEDLQVEADFPVYFEELR 594
Cdd:pfam14782 230 QNFLLPEEIEDEDESnLELKFISLRDGSPLVISVNASGKVTIRTDDMELAGDIIQSLASFLNITDLESTADFPDEMEELR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 595 KVLVKVDEYHSVHQKLSADMADHSNLIRSLLVGAEDARLMRDMKTMKSRYMELYDLNRDLLNGYKIRCNNHTELLGNLKA 674
Cdd:pfam14782 310 EILEKVDELNSVRQKLTAEMADSSNLVKSLIVRAEDARLLGDMKNMRKYYSELMDLNRDLIGEYQKRSNNHNELLSALKE 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1796340114 675 VNQAIQRAGRLRVGKPKNQVITACRDAIRSNNINTLFKIMR 715
Cdd:pfam14782 390 VNQMIQKASRLRVGKAKTQVIAACRNAIKNNNINALFKIIR 430
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 20-126 3.69e-61

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 200.17  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114  20 AIGRYDGTHPCLAAATQTGKVFIHNPHTRNQHVSASRVFQSPLESDVSLLSINQAVSCLTAGVLNPELGYDALLVGTQTN 99
Cdd:pfam14781   1 TVGKYDGVHPCLTCATTAGKVFIHNPHSRSQKLKSGRLSQSAQDSDVSLLNINQAVTALTAGRLDPDSGRDILLVGTQTN 80

                          90       100
                  ....*....|....*....|....*..
gi 1796340114 100 LLAYDVYNNSDLFYREVADGANAIVLG 126
Cdd:pfam14781  81 LLAYDVENNSDLFYKEVPDGVNAIVFG 107
BBS2_Mid pfam14783
Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association ...
 165-272 7.31e-60

Ciliary BBSome complex subunit 2, middle region; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 405473 [Multi-domain]  Cd Length: 108  Bit Score: 196.72  E-value: 7.31e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796340114 165 SLALCDFDGDGKKELLVGSEDFDIRVFKEDEIVAEMTETEIVTSLCPMYGSRFGYALSNGTVGVYDKTSRYWRIKSKNHA 244
Cdd:pfam14783   1 ALALADFDGDGENELVVGSDDFDIRVFKGDEIVFEFTETEKVTSLATLSGSRFAYALENGTVGVYDKKQRLWRIKSKNQI 80

                          90       100
                  ....*....|....*....|....*...
gi 1796340114 245 MSIHAFDLNSDGVNELITGWSNGKVDAR 272
Cdd:pfam14783  81 TALAAYDINGDGVKELIVGWSNGKVDAR 108
POLO_box_1 cd13118
First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser ...
 213-233 4.48e-03

First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240561  Cd Length: 91  Bit Score: 36.92  E-value: 4.48e-03
                          10        20
                  ....*....|....*....|...
gi 1796340114 213 YGsrFGYALSNGTVGVY--DKTS 233
Cdd:cd13118    15 YG--LGYQLSDGSVGVLfnDSTK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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