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Conserved domains on  [gi|13569938|ref|NP_112227|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 79-322 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467704  Cd Length: 244  Bit Score: 535.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  79 GYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHD 158
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 159 LLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTM 238
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 239 TIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 318
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 13569938 319 DWKP 322
Cdd:cd23976 241 DWKP 244
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 79-322 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 535.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  79 GYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHD 158
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 159 LLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTM 238
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 239 TIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 318
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 13569938 319 DWKP 322
Cdd:cd23976 241 DWKP 244
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 90-309 1.42e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 116.17  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938    90 KMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI-AHSSIQRILRNRHDLLNVSQGTVF 168
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938   169 IF---------WGPSSYMRRdGKGQVYNNLHLLSQVLPRLKafmitRHKMLQFDELFKqetgkdRKISNTWL-------- 231
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKG-NVSRSLRVLYTLKEVKIPVD-----PDKVLFLHPDFL------RYVANFWLrshglkgr 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938   232 --STGWFTMTIALELCDRINVYGMVPPDfcrdpNHPSVPYHYYEpfgpdectmYLSHERGRKGSHHRFITEKRVFKNWAR 309
Cdd:pfam00777 188 rpSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD---------NVLMKKGGFYGVHDMPFEFKLLQKLHK 253
 
Name Accession Description Interval E-value
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 79-322 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 535.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  79 GYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHD 158
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 159 LLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTM 238
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 239 TIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQP 318
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                ....
gi 13569938 319 DWKP 322
Cdd:cd23976 241 DWKP 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 93-318 7.16e-135

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 382.36  E-value: 7.16e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLL-NVSQGTVFIFW 171
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLaGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 172 GPSSYMRRDGKGqVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVY 251
Cdd:cd23965  81 GPETKMNKDGAG-KYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13569938 252 GMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGsHHRFITEKRVFKNWARTFNIHFFQP 318
Cdd:cd23965 160 GMVPENYCREHPNSKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 93-320 5.99e-123

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 352.62  E-value: 5.99e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 172
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 252
Cdd:cd23978  81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13569938 253 MVPPDFCRD-PNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDW 320
Cdd:cd23978 161 MVPPNYCSKrPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 93-320 2.35e-98

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 289.84  E-value: 2.35e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 172
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 252
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13569938 253 MVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGShHRFITEKRVFKNWARTFNIHFFQPDW 320
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSW 227
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 93-320 6.41e-84

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 253.32  E-value: 6.41e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWG 172
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYG 252
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13569938 253 MVPPDFCRDPNHPSVPYHYYEPfGPDECTMYLSHERGRKGShHRFITEKRVFKNWARTFNIHFFQPDW 320
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 96-307 6.64e-43

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 146.74  E-value: 6.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  96 CALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVS---QGTVFIFWG 172
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLpleEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFdELFKQETGKDRKisntwlSTGWFTMTIALELCDRINVYG 252
Cdd:cd19952  81 AAAADFKRLKRRKKRHDNAVLLLTDPAPDLLSYVRKRLEK-LGLKSFFGGNAP------SSGLLAVLLALQLCDSVDLYG 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13569938 253 mvppdFCRDPNH-PSVPYHYYEPFGPdectmylsherGRKGSHHRFITEKRVFKNW 307
Cdd:cd19952 154 -----FGVDSGHaPKVPYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 90-309 1.42e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 116.17  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938    90 KMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI-AHSSIQRILRNRHDLLNVSQGTVF 168
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938   169 IF---------WGPSSYMRRdGKGQVYNNLHLLSQVLPRLKafmitRHKMLQFDELFKqetgkdRKISNTWL-------- 231
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKG-NVSRSLRVLYTLKEVKIPVD-----PDKVLFLHPDFL------RYVANFWLrshglkgr 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938   232 --STGWFTMTIALELCDRINVYGMVPPDfcrdpNHPSVPYHYYEpfgpdectmYLSHERGRKGSHHRFITEKRVFKNWAR 309
Cdd:pfam00777 188 rpSTGLLMLSLALHLCDEVSLYGFGPFL-----DSRGNSHHYYD---------NVLMKKGGFYGVHDMPFEFKLLQKLHK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 96-300 3.45e-29

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 113.13  E-value: 3.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  96 CALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRI---LRNRHDL------LNVSQGT 166
Cdd:cd23963  66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRynsLKKNRDRdkflnrLKEYNGS 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 167 VFIFWGPSSYMRRDgkgQVYNNLHLLSQVLPRLK-AFMITRHKMLQFDelFKQETGKDRkisntWLSTGWFTMTIALELC 245
Cdd:cd23963 146 ILWYPKFSFKSSTN---LLLKAARALKKNGLNLTvVYSNPEHFLAVQK--FWKRRGLEK-----RPSTGLYLVSLALTFC 215

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13569938 246 DRINVYGMVPpdFCRDPNHPSVPYHYYEPFGPDEctmylshergrKGSHHRFITE 300
Cdd:cd23963 216 DEIHLYGFWP--FPTDPNGRPVPYHYYDDLSPST-----------KNKVHNMPEE 257
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 96-306 4.46e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 104.66  E-value: 4.46e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  96 CALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHssiQRILRNRHDLLNVS---QGTVFIfWG 172
Cdd:cd23968  48 CAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINS---QILSKPEFNFLTDPlyrNVTLLV-WD 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSY-------MRRDGKGqVYNNLHLLSQVLPRLKAFMITRHKMLQF-DELfkqETGKDRKISNTWLSTGWFTMTIALEL 244
Cdd:cd23968 124 PSSYnvnlekwYKKPDFD-FFPNYIKYRRRHPEEPFYLIDPRFLWRLwDIL---QEYTPEKIKPNPPSSGFIGIVLMLHL 199

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13569938 245 CDRINVYGMVPP----DFCrdpnhpsvpyHYYEPFGPDECTMylshergrkGSHHRFITEKRVFKN 306
Cdd:cd23968 200 CDWVDVYEYVPSvrqtDRC----------HYYDVEKDLACTL---------GAWHPLAAEKLLVRH 246
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 93-274 5.21e-23

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 94.67  E-value: 5.21e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI-AHSSIQRILRN------------RHD- 158
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFyPESAFRDPEEYdsdwllvlvpfkSMDl 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 159 --LLNVSQG---TVFIFWGPSSYMRRDGKGqvyNNLHLLSQVLPRLKAFMItrhkmlqfdeLFKQETGKDRKIsntWLST 233
Cdd:cd23967  82 lwLQAVIKGkkpNGKGGFWKKIATSVPKPP---KKIRILNPYILQEAAFDL----------IGLPMNGKQGKN---VPTT 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13569938 234 GWFTMTIALELCDRINVYGmvppdFCRDPNHPSVPYHYYEP 274
Cdd:cd23967 146 GIIAIVMALHYCDEVDIAG-----FGYDPSDPNAPLHYYDS 181
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 88-273 1.05e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 93.08  E-value: 1.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  88 PLK-MHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRnrhDLLNVSQGT 166
Cdd:cd23987  58 PLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFE---DLVNETWKE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 167 VF----------IFWGPsSYMRRDGKGQV--YNNLHLLSQV-----LPRLKAFMITRHKMLQFDELFKQETgkdrkisnt 229
Cdd:cd23987 135 KFlqrlqslngsILWIP-AFMAKGGEERVewVNDLILKHHInvrtaYPSLRLLHAVRGYWLTNKVHIKRPT--------- 204

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 13569938 230 wlsTGWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYE 273
Cdd:cd23987 205 ---TGLLMYTLATRFCNRIHLYGFWP--FPRDQNQNPVKYHYYD 243
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 89-276 1.57e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 92.46  E-value: 1.57e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  89 LKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNrhdLLNVSQGTVF 168
Cdd:cd23970  64 QNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNN---LLTIQDRNNF 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 169 ----------IFWGP------SSYMRR-------DGKGQVYNNLHLLSQVLPRLKAFMITRHkmlqfdelfkqetgkdrk 225
Cdd:cd23970 141 flslkkldgaILWIPafffhtSATVTRtlvdffvEHRGQLKVQLAWPGNIMQHVNRYWKTKH------------------ 202

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 13569938 226 ISNTWLSTGWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPFG 276
Cdd:cd23970 203 LSPKRLSTGILMYTLASAICEEIHLYGFWP--FGFDPTGTPLPYHYYDKKG 251
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 94-301 1.23e-20

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 89.90  E-value: 1.23e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  94 RDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAhssiQRILRN-RHDLLNVS--QGTVFIF 170
Cdd:cd23986  50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIIN----SQILTNpNHHFIDSSlyKDVILVA 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 171 WGPSSYmrrdgkgqvYNNLHLLSQ----------VLPRLK----AFMITRHKMLQfdELFK--QETGKDrKISNTWLSTG 234
Cdd:cd23986 126 WDPAPY---------SANLHKWYKkpdynlftpyVQYRKRnpnqPFYILHPKFIW--QLWDiiQENTQE-KIQPNPPSSG 193

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13569938 235 WFTMTIALELCDRINVYGMVPP----DFCrdpnhpsvpyHYYEPFGPDECTMylshergrkGSHHRFITEK 301
Cdd:cd23986 194 FIGILIMMSMCREVHVYEYIPSvrqtDLC----------HYHERYYDAACTL---------GAYHPLLYEK 245
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 88-305 2.87e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 89.01  E-value: 2.87e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  88 PLK-MHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSL-----RVIAH-------SSIQRILR 154
Cdd:cd23969  58 PLKgKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLttmnpSVIPHaygdlvnATDKEKFV 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 155 NRHDLLNVSqgtvfIFWGPsSYMRRDGKGQV-YNNLHLLSQVLPRLKAFMITRhkMLQfdelfkqetgkdrKISNTWL-- 231
Cdd:cd23969 138 ERLRQLGDS-----ILWIP-AFVSKGGEEHVqWTNEIILKHKLNVKTAYPPLR--LNH-------------AIRGYWLtt 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 232 -------STGWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPFGpdectmYLShergrKGSHHRFITEKRVF 304
Cdd:cd23969 197 kfrikrpSTGLLMYTLATRFCDEIHLYGFYP--FSEDGNGRAVKYHYYDNRK------YLT-----TARPHKMPEEFRAL 263


                .
gi 13569938 305 K 305
Cdd:cd23969 264 R 264
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 87-289 2.97e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 88.85  E-value: 2.97e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  87 KPLKmhcrDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTrGYGRDVGNRTSLrVIAHSSiqrILRNRHDLLNvsqgt 166
Cdd:cd23971  62 KPLK----TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNL-VTANPS---ILREKFHNLK----- 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 167 vfifWGPSSYMRRdgkGQVYNNLHLLsqvLPrlkAFMITRHKMLQFDELFK-QETGKD-----------RKISNTW---- 230
Cdd:cd23971 128 ----KRRRPFVER---MKVYGNALLL---LP---AFSYTSNTEPSLRALYTlEDFGSPqkvlffnpeylRNLSRYWkskg 194

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13569938 231 -----LSTGWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYY---EPFG-----PDECTMYLS-HERG 289
Cdd:cd23971 195 lkarrLSTGLMLVSAALELCENVHLYGFWP--FSTDLDGNPISHHYYdnvLPKKgvhamPEEFLRYLKlHSQG 265
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 92-317 1.47e-18

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 83.87  E-value: 1.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  92 HCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLnVSQGTVFIFW 171
Cdd:cd23966  76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVL-VPFKVLDLQW 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 172 GPSS---------YMRrdgkgqvynnlhllsqVLPRLKAfmiTRHKMLQFD-ELFKQetgkdrkISNTWL-------STG 234
Cdd:cd23966 155 LISAlttgeitrtYTP----------------VKRFIKA---DKDKVLVINpAFIKY-------VHDNWTehhgrypSTG 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 235 WFTMTIALELCDRINVYGMvppdfcrDPNHPSVPYHYYEPFgpdectmyLSHERGRKGSHHRFITEKRVFKNWARTFNIH 314
Cdd:cd23966 209 FLALIFALHICDEVSVFGF-------GADSKGNWHHYWEKN--------RSAGAFRKTGVHDADFESDIIKKLAKEGKIR 273


                ...
gi 13569938 315 FFQ 317
Cdd:cd23966 274 VYR 276
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 92-305 2.59e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 83.22  E-value: 2.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  92 HCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIahsSIQRILRNRHDLLNVS--QGTVFI 169
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI---NSQLVTTEKHKFLKDSlyNEGILI 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 170 FWGPSSY--------MRRDGKgqVYNNLHLLSQVLPRlKAFMITRHKM-LQFDELFKQETGKDrkISNTWLSTGWFTMTI 240
Cdd:cd23985 121 VWDPAPYhsdipewyKNPDYN--FFENYKTYRRLNPN-QPFYILHPQMqWELWDIIQENSPEE--IQPNPPSSGMLGIIL 195

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13569938 241 ALELCDRINVYGMVPP----DFCrdpnhpsvpyHYYEPFGPDECTMylshergrkGSHHRFITEKRVFK 305
Cdd:cd23985 196 MMTLCDQVDVYEFLPSkrktDVC----------HYYQKFFDRACTM---------GAYHPLLYEKNLVK 245
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 92-273 2.12e-16

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 76.70  E-value: 2.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  92 HCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI----AHSSIQRILRNR----------- 156
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegAPKSEQEYDPTSlfvavlfksvd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 157 -HDLLNVSQGTVFIFWGPSSYMRRDGKGQVYN--NLHLLSQVLPRLKAFmitrhKMLQFDELFKQETGKDRKISntwlST 233
Cdd:cd23983  81 fAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKpsQFRILNPLIIKETAL-----DILQYPEPQSRLWGWDKNVP----TL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 13569938 234 GWFTMTIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 273
Cdd:cd23983 152 GVTAVVLATHLCDEVSLAG-----FGYDLSQPHAPLHYYD 186
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 94-273 2.52e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 77.69  E-value: 2.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  94 RDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRI---LRNRHDLLN----VSQGT 166
Cdd:cd23988  65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNESDREKfvhrLSMLN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 167 VFIFWGPsSYMRRDGKGQV--YNNLHLLSQV-----LPRLKAFMITRHKMLQfdelfkqetgkdRKISNTWLSTGWFTMT 239
Cdd:cd23988 145 DSVLWIP-AFMVKGGEKHVewVNALILKNKLkvrtaYPSLRLIHAVRGYWLT------------NKVNIKRPSTGLLMYT 211

                       170       180       190
                ....*....|....*....|....*....|....
gi 13569938 240 IALELCDRINVYGMVPpdFCRDPNHPSVPYHYYE 273
Cdd:cd23988 212 LATRFCDEIHLYGFWP--FPKDANGNPVKYHYYD 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 88-278 1.68e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 75.25  E-value: 1.68e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  88 PLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAP-TRGYGRDVGNRTSLrVIAHSSI-----QRILRNRHDLLN 161
Cdd:cd23989  58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL-VTANPSIidkrfQNLLWSRKSFVE 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 162 VSQ--GTVFIFWgPSSYMRRdGKGQVYNNLHLLSQVlprlkafmITRHKMLQFDELFKQETG---KDRKISNTWLSTGWF 236
Cdd:cd23989 137 SMKvyGRSYIYM-PAFSMKT-GTDPSLRVYYTLADV--------GANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGLF 206

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 13569938 237 TMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPFGPD 278
Cdd:cd23989 207 LVSAALGLCEEVTIYGFWP--FSVDLDERTISHHYYDNVLPD 246
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 93-273 2.94e-14

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 70.72  E-value: 2.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI-AHSSIQRILRNRHDllnvsqgTVFIFW 171
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITyPEGAIQKPEQYEKD-------SLFVLA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 172 GPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITR--HKMLQFDELFKQETGKD---RKISNTWL------STGWFTMTI 240
Cdd:cd23981  75 GFKWQDFKWLKYIVYKEKVSASDGFWKSVATRVPRepHEIRILNPYFIQEAAFSfigLPFNNGLMgrgnipTLGSVAITM 154

                       170       180       190
                ....*....|....*....|....*....|...
gi 13569938 241 ALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 273
Cdd:cd23981 155 ALHNCDEVAVAG-----FGYDMNTPNAPLHYYE 182
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 93-273 6.31e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 69.69  E-value: 6.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI----AHSSIQriLRNRHDLLnvsqgTVF 168
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesAQFDPG--IENDPDTL-----LVL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 169 IFWGPSsymrrdgkgqvynNLHLLSQVL--------------PRLKAFMITRHKMLqfDELFKQETGkdRKISNTWL--- 231
Cdd:cd23982  75 VPFKPL-------------DFYWLYEILsnekrvrkgfwkqpPRIWDANPKQIRIL--NPYYTYVAA--TKLLQVPGqrk 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 13569938 232 -----STGWFTMTIALELCDRINVYGMVPPDfcrdpNH-PSVPYHYYE 273
Cdd:cd23982 138 kkqkpTTGLLAITLALHLCDEVHIAGFGYPD-----NGnSNQPIHYYN 180
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 74-305 2.49e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.40  E-value: 2.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  74 PRPLDGYLgVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRV-IAHSSIQ-- 150
Cdd:cd23973  65 PKPKEQQL-LALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVhTAHSITSsl 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 151 RILRNRhDLLNVSQGT----VFIFWGPssymrRDgkgqvYNNLH--LLSQVLPRlkAFMITRHKMLQFDELFKQET---- 220
Cdd:cd23973 144 MILQKR-GFKNIPQDKdikyILFPEGP-----RD-----YQWLEalLKNKTIPS--GAYYGRRPRSYFSGDFTEDKylvl 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 221 --------------GKDRKISNTWL---STGWFTMTIALELCDRINVYGMVPPDFCRDPNhpsvpyHYYEpfgpdectmy 283
Cdd:cd23973 211 hpdflryvknrflrSKTLKGKYWAIyrpTTGAFLLLTALHLCDTVSAYGFITEDYRKYPD------HYYD---------- 274

                       250       260
                ....*....|....*....|..
gi 13569938 284 LSHERGRKGSHHRFITEKRVFK 305
Cdd:cd23973 275 KKKTKLVFYINHDFRLEKKLWK 296
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 93-273 4.91e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 68.44  E-value: 4.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVI-AHSSIQRILRNrhdlLNVSQGTVFIFW 171
Cdd:cd23964  82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFfPESLHNSLLKH----VPQDKDTKYLFI 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 172 gPSS-----YMRRDGKGQVYNNLHLLSQVLPRLKAFMITRH--KMLQFDELfkqetgkdRKISNTWL--------STGWF 236
Cdd:cd23964 158 -PFKirdydYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATnvRLLHPDFI--------RYLFNRWLnsstsyrpTTGAL 228

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 13569938 237 TMTIALELCDRINVYGmvppdFCRDPNHPSvpyHYYE 273
Cdd:cd23964 229 MLLTALHTCDQVSVYG-----FGYDPRFSL---HYYD 257
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 93-273 8.89e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 66.31  E-value: 8.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSI-------------------QRIL 153
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpshydpnttvvlipfkPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 154 RNRHDLLNVSQGTVFIFWgpssymRRDGKGQVY--NNLHLLSQVLPRLKAFmitrhKMLQFDELFKQEtgkDRKISNTwl 231
Cdd:cd23984  82 RWLLDLLMGKKVSAKGFW------KKPALNLIYkpNQIRILNPFILRIAAY-----ELLHFPKRFPKE---KKPKHPT-- 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 13569938 232 sTGWFTMTIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 273
Cdd:cd23984 146 -TGIIAITLALHICNEVHIAG-----FKYDFSNLNSTLHYYG 181
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 92-252 9.53e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 61.43  E-value: 9.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  92 HCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRH---------DLL-- 160
Cdd:cd23979  79 RCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSfvlvpfktlDLLwi 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 161 --NVSQGTVFIFWGP-SSYMRRDG-KGQVYNnlhllsqvlprlKAFmitrhkmlqfdelFKQETGKDRKISNTWLSTGWF 236
Cdd:cd23979 159 tsALSTGQIRFTYAPvKQFLRVDKdKVQIYN------------PAF-------------FKYIHDRWTEHHGRYPSTGML 213

                       170
                ....*....|....*.
gi 13569938 237 TMTIALELCDRINVYG 252
Cdd:cd23979 214 VLFFALHVCDEVNVYG 229
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 93-252 1.67e-10

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 61.05  E-value: 1.67e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLnVSQGTVFIFWG 172
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMIL-VPFKTLDLEWV 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 173 PSSYMrrdgKGQVYNNLhllsqvLPRLKAFMITRHKMLQFDELFKqetgkdRKISNTWL-------STGWFTMTIALELC 245
Cdd:cd23980 160 ISATT----TGTISHTY------VPVPRKIKVKKEKILIYHPAFI------KYVFDRWLqghgrypSTGILSVIFSLHVC 223


                ....*..
gi 13569938 246 DRINVYG 252
Cdd:cd23980 224 DEVDLYG 230
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 96-273 2.41e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 60.15  E-value: 2.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  96 CALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRG-YGRDVGNRTSLrVIAHSSIqrILRNRHDLLNVSQgtvfIFWGPS 174
Cdd:cd23991  67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSI--ISIKYAKLNERRK----PFLETV 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 175 SymrrdgkgqVYNNLHLLsqvlprLKAFMITRHKMLQFDELFKQETGKDRK------------ISNTW---------LST 233
Cdd:cd23991 140 S---------VYGDAFLL------LPAFSYRSNTALSFKVYYTLEDFKAKQkviffhpiylkhLAQFWrskgvqvyrLST 204

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 13569938 234 GWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYE 273
Cdd:cd23991 205 GLMITSAALELCEEVKLYGFWP--FSKNTEGKPISHHYYD 242
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 93-274 5.75e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 53.60  E-value: 5.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDL----LNVSQGTVF 168
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVgfngPPQSKETRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 169 IFW---------------------------GPSSYMRRDGKGQVYNNLHllsqvlPRLKAFMitRHKMLQFDELfkqeTG 221
Cdd:cd23974 164 IFLpdhdrdyllvkaalthtpidrgrdkskRPSKYFGKDVTAEKFKIYH------PDFIRYL--RNRFLWSPIL----NT 231

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 13569938 222 KDRKISNTwlSTGWFTMTIALELCDRINVYGMVPPDFCRDPNhpsvpyHYYEP 274
Cdd:cd23974 232 KQRDIYRP--STGAVMLLAALHTCDQVSAYGFMTPDYGKYSD------HYYDK 276
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 93-274 3.77e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 50.98  E-value: 3.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  93 CRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQR--ILRNRHDLLNVSQGT---- 166
Cdd:cd23972  82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNslISYWNLGFTRTPQGQdlqy 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 167 VFIfwgPSSYmrRDgkgqvYNNLHLLSQVLP---------RLKAFMITRH-----KMLQFDEL-FKQETGKDRKISNTWL 231
Cdd:cd23972 162 IFI---PSDI--RD-----YVMLRSAILGVPvpegldkgdRPHKYFGPEAsakkfKLLHPDFIsYLTDRFLKSKLLNTHY 231

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 13569938 232 ------STGWFTMTIALELCDRINVYGMVPPDFCRDPNhpsvpyHYYEP 274
Cdd:cd23972 232 ghlympSTGALMLLTALHTCDQVSAYGFITSNYWKFSD------HYYER 274
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 94-277 1.64e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 45.60  E-value: 1.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938  94 RDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAP-TRGYGRDVGNRTSLRVIAHSSI----QRILRNRHDLLNVSqgtvf 168
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIIterfHKLEKWRRPFYEVL----- 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13569938 169 ifwgpssymrrdgkgQVYNNlhlLSQVLPrlkAFMITRHKMLQF------DELFKQET------GKDRKISNTWL----- 231
Cdd:cd23990 140 ---------------QVYEN---ASVVLP---AFYNTRNTDVSIrvkyvlDDFESQQAvyyfhpQYLLNVSRFWLrqgvr 198

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 13569938 232 ----STGWFTMTIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPFGP 277
Cdd:cd23990 199 akriSSGLMLVTAALELCEEVHLYGFWA--FPMNPSGIFITHHYYDNVKP 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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