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Conserved domains on  [gi|205360932|ref|NP_073600|]
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fibronectin type III domain-containing protein 3B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.68e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401   348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401   425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                         330
                  ....*....|....*....
gi 205360932  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401   503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.16e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401   269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401   341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401   418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         330       340
                  ....*....|....*....|....*....
gi 205360932 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401   498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
347-643 1.46e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401   355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205360932  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401   435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.33e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 205360932  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.41e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.68e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401   348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401   425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                         330
                  ....*....|....*....
gi 205360932  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401   503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.16e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401   269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401   341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401   418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         330       340
                  ....*....|....*....|....*....
gi 205360932 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401   498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 572-666 8.70e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 8.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  572 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 205360932  652 TGGHSQCSESLPVRT 666
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
347-643 1.46e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401   355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205360932  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401   435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 572-656 4.09e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.09e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    572 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 650
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 205360932    651 STGGHS 656
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-567 4.12e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  478 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:cd00063     1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 205360932  554 EGKSCPSEVLVCTT 567
Cdd:cd00063    80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
382-463 7.41e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 7.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   382 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 205360932   461 GYS 463
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
573-657 1.62e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   573 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 652
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 205360932   653 GGHSQ 657
Cdd:pfam00041   79 GGEGP 83
fn3 pfam00041
Fibronectin type III domain;
886-947 5.22e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 5.22e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   886 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 947
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 886-954 4.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 4.30e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205360932  886 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.33e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 205360932  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 379-460 5.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    379 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 205360932    457 IGTS 460
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.41e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 280-357 1.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360932    280 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 357
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
282-357 1.73e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.73e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932   282 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 357
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1014-1127 4.66e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932 1014 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 1090
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 205360932 1091 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
1054-1127 5.94e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.94e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932  1054 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 861-944 6.72e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.72e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    861 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 932
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 205360932    933 IRIQAINEIGAG 944
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1054-1127 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 2.49e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360932   1054 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.68e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401   348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401   425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                         330
                  ....*....|....*....
gi 205360932  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401   503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
566-948 1.62e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 94.30  E-value: 1.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  566 TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKL 645
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  646 RACCISTGGHSQCSESLPVRTLSIAPGQcrPPRVLGRPK-HKEVHLEWDvPASESGceVSEYSVEMTEPEDVA-SEVYHG 723
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  724 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGqckAP----CISCTPDGCVLvGWEspDSSGADIS 798
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPA---APsgltATAVGSSSITL-SWT--ASSDADVT 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  799 EYRLEWGEDEE-SLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLcQTPASAPDPVSTLCVLEEEPL 875
Cdd:COG3401   357 GYNVYRSTSGGgTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVS-ATTASAASGESLTASVDAVPL 435

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205360932  876 DAYPDSPSACLVLNWeepcNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
Cdd:COG3401   436 TDVAGATAAASAASN----PGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
447-672 8.11e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.44  E-value: 8.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  447 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGcspEEVITYTLEIQEDENDNlFHPKY 526
Cdd:COG3401   205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  527 TGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGgseIL 605
Cdd:COG3401   281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  606 KYLLEItdGNSEANQWE-VAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPG 672
Cdd:COG3401   357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.16e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401   269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401   341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401   418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                         330       340
                  ....*....|....*....|....*....
gi 205360932 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401   498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 572-666 8.70e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 8.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  572 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 205360932  652 TGGHSQCSESLPVRT 666
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
347-643 1.46e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401   355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205360932  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401   435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 671-762 2.09e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  671 PGQCRPPRVLGRPKHkEVHLEWDVPASESGcEVSEYSVEMTEPEDVASEVY---HGPELECTVGNLLPGTVYRFRVRALN 747
Cdd:cd00063     1 PSPPTNLRVTDVTST-SVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 205360932  748 DGGYGPYSDVSEITT 762
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 572-656 4.09e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.09e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    572 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 650
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 205360932    651 STGGHS 656
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-567 4.12e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  478 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:cd00063     1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 205360932  554 EGKSCPSEVLVCTT 567
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 379-470 9.16e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 9.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  379 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 205360932  457 IGTSGYSQEVVCYT 470
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
927-1127 4.37e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.95  E-value: 4.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  927 PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRL-ECAAAGPQSLKLKWgDSNSKTHAAEDIVYtlQLEDRNKRFI 1005
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932 1006 SIYRGPSHTYKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSmkGDP 1084
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 205360932 1085 VNYILQVLVGRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:COG3401   356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
382-463 7.41e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 7.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   382 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 205360932   461 GYS 463
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
573-657 1.62e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   573 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 652
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 205360932   653 GGHSQ 657
Cdd:pfam00041   79 GGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 767-856 1.76e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 1.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  767 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIY---HGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 205360932  844 GAGPYSELVLCQT 856
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
886-947 5.22e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 5.22e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   886 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 947
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
687-755 8.50e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 8.50e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205360932   687 EVHLEWDVPASESGcEVSEYSVE---MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
Cdd:pfam00041   15 SLTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 671-752 1.25e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    671 PGQCRPPRVLGRPKHkEVHLEWDVPASE-SGCEVSEYSVEMTEPEDVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 748
Cdd:smart00060    1 PSPPSNLRVTDVTST-SVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 205360932    749 GGYG 752
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 886-954 4.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 4.30e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205360932  886 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
783-849 5.54e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 5.54e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   783 VLVGWESPDSSGADISEYRLEW---GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
283-635 1.28e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  283 QVSNIQARAVVLSWAPPvglscgPHSGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAM-YNS 361
Cdd:COG3401   240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  362 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFRQ-CFFGSQKHCKLTK 440
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  441 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSkpEGCSPEEVITYTLEIQEDENDN 520
Cdd:COG3401   387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGAT--AAASAASNPGVSAAVLADGGDT 464

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  521 LFHPKYTGEDLTcTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTShgfSVKWDPPKDNG 600
Cdd:COG3401   465 GNAVPFTTTSST-VTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPN---VTGASPVTVGA 540

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 205360932  601 GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 635
Cdd:COG3401   541 STGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.33e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 205360932  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 379-460 5.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    379 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 205360932    457 IGTS 460
Cdd:smart00060   80 AGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
590-786 7.15e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 7.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  590 SVKWDPPKDNGGseilkYLLEITDGNSEanqWEVAYSGSATEYTFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 668
Cdd:COG4733   555 TVSWDAPAGAVA-----YEVEWRRDDGN---WVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  669 -IAPgqcrPPRVLG---RPKHKEVHLEWDVPAsesGCEVSEYSVEMTEPEDVAS---EVYHGPELECTVGNLLPGTVYRF 741
Cdd:COG4733   626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYSTTGDWASatvAQALYPGNTYTLAGLKAGQTYYY 698

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 205360932  742 RVRALNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
Cdd:COG4733   699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDA 744
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-557 5.71e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.71e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    478 PSAPRLVRA---GITWVTLQWSKPEGCSPEE-VITYTLEIQEDENDNLFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:smart00060    1 PSPPSNLRVtdvTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 205360932    554 EGKS 557
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.41e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.41e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 767-846 9.05e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 9.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    767 PGQCKAPCISCTPDGCVLVGWESPDSSGAD--ISEYRLEWGE-DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 205360932    844 GAG 846
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 280-357 1.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360932    280 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 357
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
478-560 1.72e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932   478 PSAPRLVRAGITWVTLQWSKPEGCSpEEVITYTLEIQE-DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK 556
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 205360932   557 SCPS 560
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
282-357 1.73e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.73e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932   282 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 357
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 970-1049 1.77e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  970 GPQSLKLKWgdSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYT 1046
Cdd:cd00063    13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                  ...
gi 205360932 1047 FST 1049
Cdd:cd00063    91 VTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1014-1127 4.66e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932 1014 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 1090
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 205360932 1091 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
1054-1127 5.94e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.94e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932  1054 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 861-944 6.72e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.72e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932    861 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 932
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 205360932    933 IRIQAINEIGAG 944
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 968-1039 1.02e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.02e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205360932    968 AAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG 1039
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1054-1127 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 2.49e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205360932   1054 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
491-654 1.16e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  491 VTLQWSKPEGcspeeVITYTLEIQEDenDNLFHPKYTGEDLTCTVKNLKrSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
Cdd:COG4733   554 LTVSWDAPAG-----AVAYEVEWRRD--DGNWVSVPRTSGTSFEVPGIY-AGDYEVRVRAINALGVSSAWAASSETTVTG 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205360932  571 RPGPPTRP----LVKGPvtsHGFSVKWDPPKDnggSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
Cdd:COG4733   626 KTAPPPAPtgltATGGL---GGITLSWSFPVD---ADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYR 699


                  ....*...
gi 205360932  647 ACCISTGG 654
Cdd:COG4733   700 ARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
973-1042 4.30e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 4.30e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205360932   973 SLKLKWgdSNSKTHAAEDIVYTLQLEDRNK------RFISiyrGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFS 1042
Cdd:pfam00041   15 SLTVSW--TPPPDGNGPITGYEVEYRPKNSgepwneITVP---GTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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